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Discontinuity and dislocation of ear ossicles

DOID EFO Endpoint Browser PheWeb

H8_DISCON

Otitis media: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H74.2
  • Cause of death: ICD-10 — H74.2

2 out of 7 registries used, show all original rules.

220

4. Check minimum number of events

None

220

5. Include endpoints

None

220

6. Filter based on genotype QC (FinnGen only)

193

Control definitions (FinnGen only)

Control exclude
H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H74
Name in latin
Discontinuitas ossiculorum auditoriorum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1329 614 704
Only index persons 1268 593 675
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.03
Median age at first event (years)
Whole population 44.71 48.15 41.81
Only index persons 45.31 48.21 42.77

-FinnGen-

Key figures

All Female Male
Number of individuals 193 103 90
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 52.46 50.61 54.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
206
Matched controls
2060
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
298.3
206
*
DFF00
NOMESCO Finland
Pure tone audiometry
20.7
109.1
111
110
DCD10
NOMESCO Finland
Tympanoplasty
+∞
100.4
88
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
286.8
89.1
85
5
UDC00
NOMESCO Finland
Ear microscopy
15.6
72.1
75
73
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
66.3
60
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
+∞
62.8
57
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
9.8
57.9
92
156
DC1AD
NOMESCO Finland
Temporalbone CT
201.6
47.0
47
*
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
+∞
35.4
33
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
394.6
33.9
33
*
DFF15
NOMESCO Finland
Speech audiometry
10.2
32.9
41
49
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
336.9
29.6
29
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
8.2
28.8
43
64
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
111.9
27.4
29
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
46.9
26.7
32
8
DCD00
NOMESCO Finland
Myringoplasty
+∞
25.5
24
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
23.4
22
*
ZXC10
NOMESCO Finland
Use of laser
20.1
22.7
34
20
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
90.2
22.2
24
*
Z3229
NOMESCO Finland
Other healthcare associate professional
6.5
21.7
40
74
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
19.0
18
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
208.2
18.9
19
*
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
18.0
17
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
6.3
17.6
32
58
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
16.9
16
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.5
16.5
80
313
H65.2
ICD-10 Finland
Chronic serous otitis media
172.6
15.7
16
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
49.0
15.3
18
*
DAX08
NOMESCO Finland
Fitting of hearing aid
5.6
15.1
31
63
DDD10
NOMESCO Finland
Interposition between malleus and stapes
+∞
14.8
14
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
5.9
14.1
27
51
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
13.7
13
*
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
30.7
13.2
17
6
H66.9
ICD-10 Finland
Otitis media, unspecified
5.7
13.1
26
51
Z97.4
ICD-10 Finland
Presence of external hearing-aid
6.3
13.0
23
40
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
+∞
12.6
12
*
H80.9
ICD-10 Finland
Otosclerosis, unspecified
28.7
12.2
16
6
H60.9
ICD-10 Finland
Otitis externa, unspecified
4.8
11.9
29
68
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
11.6
11.6
21
20
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
+∞
11.6
11
*
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
37.3
11.4
14
*
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
10.5
10
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
10.5
10
*
H29
ICPC
Ear symptom/complaint other
3.5
10.2
39
128
DDA00
NOMESCO Finland
Stapedotomy
27.6
9.9
13
5
WX110
NOMESCO Finland
Infiltration anesthesia
3.2
9.6
172
1255
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
9.4
9
*
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
9.4
9
*
ZXA00
NOMESCO Finland
Right side
2.6
9.1
67
318
H92.0
ICD-10 Finland
Otalgia
4.6
8.9
22
52
WX704
NOMESCO Finland
Intubation
3.8
8.7
28
81
DBD10
NOMESCO Finland
Reconstruction of external auditory canal
+∞
8.4
8
*
4122
FHL
Tympanostomy (tympanic tube)
+∞
8.4
8
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
8.4
8
*
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
+∞
8.4
8
*
WX002
NOMESCO Finland
Sedation and analgesia
2.8
8.4
50
212
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
2.8
8.2
48
201
H01
ICPC
Ear pain/earache
3.1
8.2
38
140
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
34.9
8.2
10
*
WX720
NOMESCO Finland
Own respiration
4.5
7.7
19
45
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
14.1
7.5
12
9
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
7.3
7
*
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
+∞
7.3
7
*
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
7.3
7
*
ZZG00
NOMESCO Finland
Graft of cartilage
+∞
7.3
7
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.5
6.9
17
40
H69.0
ICD-10 Finland
Patulous Eustachian tube
41.5
6.8
8
*
H61.8
ICD-10 Finland
Other specified disorders of external ear
23.4
6.7
9
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
6.5
40
171
S02CA02
ATC
flumetasone and antiinfectives; otic
4.1
6.4
18
47
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.2
6.4
67
365
WX725
NOMESCO Finland
Noninvasive ventilation
3.8
6.3
20
57
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
+∞
6.3
6
*
H90.2
ICD-10 Finland
Conductive hearing loss, unspecified
+∞
6.3
6
*
4141
FHL
Myringoplasty (also for reasons other than inflammation)
+∞
6.3
6
*
DDD20
NOMESCO Finland
Interposition between eardrum and footplate of stapes
+∞
6.3
6
*
38199
ICD-8 Finland
Otitis media without mention of mastoiditis, Unspecified
+∞
6.3
6
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
+∞
6.3
6
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
5.5
6.2
17
33

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
44
190
2.67
7.03
2.6
1.6
—
—
—
0
0
38
209
2.00
3.38
1.9
1.4
—
—
—
0
0
54
337
1.82
3.29
4.4
3.6
443.34
291.96
ng/l
0.16
46
238
62
864
0.60
2.90
12.3
10.5
0.00
0.00
e9/l
0.43
52
692
13
49
2.76
2.68
5.3
2.5
—
—
—
0
0
100
773
1.57
2.60
8.3
6.3
1.21
1.21
mmol/l
0.06
92
718
25
417
0.54
2.17
5.1
5.3
—
—
—
0
0
150
1309
1.54
2.00
3.3
3.3
49.76
47.02
u/l
0.15
145
1239
105
855
1.47
1.96
8.7
7.1
1.21
1.21
mmol/l
0.22
91
737
38
249
1.65
1.91
1.6
1.8
—
—
—
0
0
58
766
0.66
1.90
2.6
3.1
—
—
—
0
0
199
1891
2.54
1.88
11.9
11.6
29.01
27.94
u/l
0.20
193
1856
68
515
1.48
1.81
3.5
2.9
—
0.18
—
0
11
29
180
1.71
1.78
11.8
7.8
7.44
7.42
ph
0.84
16
101
93
753
1.43
1.73
2.2
2.0
103.39
96.54
pmol/l
0.39
40
373
5
132
0.36
1.69
5.0
4.0
1.25
1.23
mmol/l
—
5
119
24
144
1.75
1.66
2.6
4.6
7.38
7.34
ph
0.88
14
98
6
20
3.06
1.59
1.2
1.2
—
—
—
0
0
20
118
1.77
1.47
1.4
1.2
—
—
—
0
0
99
828
1.38
1.46
2.6
2.7
—
—
estimate
—
0
0
36
250
1.53
1.44
2.4
2.4
243.51
116.59
ug/g
0.40
30
200
10
46
2.23
1.42
1.8
1.3
—
—
—
0
0
71
565
1.39
1.41
2.6
3.5
—
—
—
0
0
152
1369
1.42
1.40
7.8
8.1
79.01
80.05
u/l
0.07
140
1296
102
864
1.36
1.36
7.9
6.3
0.71
0.66
%
0.38
97
813
26
170
1.61
1.34
1.3
1.2
—
—
—
0
0
5
18
2.82
1.29
3.0
1.8
10.78
11.68
%
—
5
18
5
18
2.82
1.29
4.0
1.6
19.04
42.20
ng/l
—
5
18
39
521
0.69
1.27
2.7
3.8
0.00
0.01
estimate
—
7
194
74
602
1.36
1.26
8.6
6.1
—
—
—
0
0
44
574
0.70
1.26
5.3
3.0
86.23
41.23
e6/l
0.31
32
437
26
173
1.58
1.25
1.7
1.6
—
—
—
0
0
193
1837
1.80
1.24
13.2
12.4
—
—
—
0
0
112
974
1.33
1.21
4.7
6.5
9.75
10.86
umol/l
0.92
104
930
35
254
1.46
1.15
1.4
1.6
892.18
1168.20
nmol/l
1.31
28
196
5
21
2.41
1.09
2.4
2.5
—
—
—
0
0
188
1794
1.55
0.97
18.5
16.2
139.69
139.71
mmol/l
0.04
182
1765
9
51
1.80
0.96
1.2
2.1
—
—
—
0
0
11
63
1.79
0.92
2.1
1.9
1.33
0.56
ug/l
0.57
11
58
52
420
1.32
0.91
2.0
2.1
2.08
2.93
mg/l
2.69
44
370
86
743
1.27
0.91
3.4
3.4
6.30
6.19
ph
0.41
38
428
188
1799
1.52
0.90
18.8
16.3
3.99
3.96
mmol/l
1.03
181
1761
6
30
2.03
0.87
1.5
1.2
—
—
—
0
0
13
80
1.67
0.87
2.8
2.3
—
—
—
0
0
54
444
1.29
0.83
3.4
4.4
—
—
—
0
0
178
1692
1.38
0.83
5.1
5.0
5.72
5.90
mmol/l
1.37
165
1572
68
577
1.27
0.82
2.7
2.4
55.63
70.87
u/l
0.68
63
531
174
1649
1.36
0.82
5.6
5.1
1.81
1.89
mu/l
0.47
160
1528
143
1529
0.79
0.80
21.9
17.5
13.69
13.50
%
0.94
143
1523
5
96
0.51
0.80
1.4
1.7
—
—
—
0
0
0
24
0.00
0.79
0.0
1.5
—
—
—
0
0
60
504
1.27
0.78
1.8
1.6
18.65
21.42
nmol/l
0.88
52
435
6
34
1.79
0.77
1.2
1.2
36.91
25.25
u/l
—
6
29
7
44
1.61
0.66
1.4
1.4
3393.14
11845.24
e6/l
—
7
29
5
29
1.74
0.64
1.4
1.2
—
—
—
0
0
5
29
1.74
0.64
1.0
1.1
—
—
—
0
0
93
839
1.20
0.60
3.2
2.9
121.78
110.31
ug/l
0.29
87
791
0
20
0.00
0.60
0.0
2.5
—
3.94
—
0
20
0
20
0.00
0.60
0.0
2.5
—
106.20
—
0
20
0
20
0.00
0.60
0.0
2.5
—
1.19
—
0
20
57
656
0.82
0.60
6.2
3.6
25.09
78.79
e6/l
1.11
34
456
79
703
1.20
0.59
2.0
2.0
—
—
—
0
0
104
949
1.19
0.59
7.4
6.4
0.05
0.04
e9/l
1.32
95
815
0
23
0.00
0.58
0.0
1.9
—
91.28
—
0
23
6
35
1.74
0.58
1.3
1.1
—
—
—
0
0
185
1788
1.34
0.58
5.9
5.6
2.86
2.75
mmol/l
1.01
174
1682
5
87
0.56
0.57
1.2
1.3
—
—
—
0
0
147
1387
1.21
0.57
4.4
4.2
14.45
14.71
pmol/l
0.71
137
1272
6
37
1.64
0.56
1.3
1.3
—
—
—
0
0
41
484
0.81
0.55
5.4
2.8
0.20
0.37
e6/l
1.04
28
347
17
126
1.38
0.53
1.0
1.2
34.64
121.49
u/ml
—
8
51
6
99
0.59
0.53
2.7
2.2
1.05
1.34
%
—
6
99
6
99
0.59
0.53
2.7
2.2
0.62
0.64
%
—
6
99
28
225
1.28
0.53
9.8
6.7
103.68
104.28
mmol/l
0.37
28
225
11
156
0.69
0.52
1.2
1.3
—
—
—
0
0
13
92
1.44
0.52
1.2
1.3
—
—
—
0
0
11
75
1.49
0.52
2.9
3.5
—
—
—
0
0
65
575
1.19
0.52
5.4
5.1
1.65
1.88
ug/l
0.46
58
517
42
356
1.23
0.51
1.3
1.3
66.79
24.00
iu/ml
—
7
123
182
1762
1.28
0.50
15.5
14.2
20.21
23.16
mg/l
0.72
151
1416
20
155
1.32
0.49
14.4
7.9
—
—
—
0
0
64
570
1.18
0.47
2.2
2.4
—
—
—
0
0
47
538
0.84
0.47
2.5
3.3
0.00
0.15
estimate
—
6
170
5
85
0.58
0.46
1.2
1.4
—
—
—
0
0
173
1672
1.22
0.43
6.0
6.0
38.83
39.00
mmol/mol
0.09
165
1581
105
978
1.15
0.42
7.9
6.7
0.20
0.19
e9/l
0.16
96
859
18
226
0.78
0.41
1.3
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
182.52
—
0
17
7
105
0.66
0.40
1.6
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
69
756
0.87
0.39
2.4
1.9
1.33
1.38
mmol/l
0.18
56
640
15
116
1.32
0.38
5.9
3.3
24.07
24.45
mmol/l
0.21
15
116
32
273
1.20
0.38
5.2
2.8
0.71
2.14
e6/l
1.32
16
134
101
946
1.13
0.36
7.5
6.4
0.64
0.58
e9/l
1.23
91
813
25
209
1.22
0.36
1.2
1.5
—
—
—
0
0
5
80
0.62
0.36
1.8
2.1
2.32
1.51
g/l
—
5
74
53
477
1.15
0.34
2.8
2.8
—
—
—
0
0
103
969
1.13
0.34
7.6
6.4
2.01
1.94
e9/l
0.28
95
857
13
101
1.31
0.32
16.6
10.5
93.87
93.53
%
0.06
13
101
82
763
1.12
0.32
5.0
4.9
36.48
36.23
g/l
0.14
76
731
27
231
1.19
0.32
1.3
1.2
—
—
—
0
0
7
96
0.72
0.31
1.6
1.5
—
—
—
0
0
7
52
1.36
0.31
3.3
2.3
66.24
61.52
%
—
7
52
181
1769
1.19
0.30
5.3
5.0
4.85
4.65
mmol/l
1.76
171
1671
13
161
0.79
0.28
2.2
2.0
6.58
6.11
ph
—
6
105
8
67
1.20
0.26
2.1
1.3
—
—
—
0
0
10
77
1.31
0.26
1.1
1.7
—
5.48
—
0
20
5
71
0.70
0.26
2.0
1.5
18.60
20.17
s
—
5
65
180
1764
1.16
0.25
5.1
4.9
1.47
1.45
mmol/l
0.24
169
1654
11
135
0.80
0.22
6.3
4.8
0.00
0.31
%
—
5
36
60
560
1.10
0.22
5.0
6.4
—
—
—
0
0
8
103
0.77
0.21
1.5
1.5
—
—
—
0
0
5
42
1.20
0.21
1.4
1.6
—
—
—
0
0
8
104
0.76
0.21
1.5
1.4
—
—
—
0
0
8
105
0.75
0.21
1.5
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
109.50
—
0
11
0
10
0.00
0.21
0.0
1.0
—
1638.30
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
23
202
1.16
0.21
1.5
1.4
—
—
—
0
0
43
395
1.11
0.21
1.4
1.7
1.10
1.28
mg/l
0.18
34
307
0
13
0.00
0.21
0.0
1.6
—
6.97
—
0
13
0
13
0.00
0.21
0.0
1.7
—
24.55
—
0
13
12
144
0.82
0.20
5.8
4.7
1.50
1.13
%
—
6
45
68
720
0.92
0.20
2.9
3.6
0.00
0.02
estimate
—
7
178
0
14
0.00
0.20
0.0
1.4
—
22.27
—
0
14
172
1688
1.11
0.19
4.2
4.2
1.29
1.30
mmol/l
0.05
161
1566
58
616
0.92
0.18
4.3
3.2
7.53
7.97
mmol/l
0.35
47
524
7
58
1.21
0.18
1.1
1.1
—
—
—
0
0
7
59
1.19
0.18
2.1
3.2
25.50
163.05
mg/l
—
7
51
7
59
1.19
0.18
2.1
3.2
17.17
30.94
mg/l
—
7
52
15
173
0.86
0.17
2.6
2.5
0.20
0.22
g/l
0.64
15
157
10
82
1.23
0.17
1.1
1.1
1.54
1.55
g/l
—
10
82
70
665
1.08
0.17
2.5
3.6
21.57
26.59
ng/l
0.27
43
451
6
79
0.75
0.16
1.5
1.9
—
—
—
0
0
44
413
1.08
0.14
3.5
3.9
1.02
1.02
kg/l
0.30
24
270
98
948
1.06
0.14
3.6
3.7
0.00
0.00
estimate
—
7
206
57
599
0.93
0.14
2.8
3.3
2.38
2.36
mmol/l
0.64
52
550
83
800
1.06
0.13
11.3
10.4
1.21
1.18
inr
0.24
67
645
12
137
0.87
0.12
5.3
4.7
0.83
0.88
%
—
6
40
21
191
1.11
0.12
3.6
1.9
416.29
386.42
nmol/l
0.39
21
180
18
162
1.12
0.12
1.9
1.6
—
—
—
0
0
25
231
1.09
0.11
1.9
1.5
—
—
—
0
0
10
86
1.17
0.11
1.1
1.2
0.85
0.89
g/l
—
10
86
46
482
0.94
0.10
1.4
1.3
1.47
1.08
u/ml
—
10
141
5
44
1.14
0.10
2.0
1.4
—
—
—
0
0
5
44
1.14
0.10
1.6
2.7
7.38
7.41
ph
—
5
44
5
47
1.07
0.09
1.8
1.3
—
—
—
0
0
18
196
0.91
0.09
1.8
1.5
—
—
—
0
0
41
430
0.94
0.09
1.3
1.5
2.84
2.51
g/l
0.66
25
257
12
107
1.13
0.08
2.8
3.8
4.50
4.79
pmol/l
0.48
12
94
13
144
0.90
0.08
5.2
5.1
0.14
0.22
%
—
7
37
5
60
0.83
0.08
5.6
3.4
1.60
1.37
mg/l
—
5
55
5
60
0.83
0.08
8.4
9.9
—
—
—
0
0
6
73
0.82
0.07
2.2
1.8
—
—
—
0
0
14
153
0.91
0.07
2.5
2.8
4.44
4.53
kpa
0.07
14
147
11
99
1.12
0.06
1.6
1.5
0.13
0.37
mg/l
—
5
43
22
207
1.07
0.06
1.6
1.8
—
—
—
0
0
12
110
1.10
0.05
17.7
7.5
24.38
25.17
mmol/l
0.45
12
110
25
262
0.95
0.05
1.7
1.6
—
—
—
0
0
36
349
1.04
0.04
3.2
2.9
0.73
0.76
ug/l
0.07
24
213
21
219
0.95
0.03
1.9
3.1
4.55
9.23
umol/l
1.65
16
198
57
561
1.02
0.02
4.6
4.1
2.36
8.46
mg/mmol
2.95
32
343
95
941
1.02
0.02
3.5
3.7
0.00
0.00
estimate
—
7
204
10
107
0.93
0.02
1.0
1.1
—
—
—
0
0
54
532
1.02
0.01
1.3
1.5
—
—
—
0
0
104
1048
0.98
0.01
6.6
4.7
6.90
6.54
mmol/l
0.76
95
987
19
184
1.04
0.00
4.9
3.5
7.36
7.39
ph
—
10
105
11
111
0.99
0.00
2.3
2.4
—
—
—
0
0
17
169
1.01
0.00
1.5
1.8
3.12
3.52
mmol/l
—
10
129
39
394
0.99
0.00
1.9
2.1
—
—
—
0
0
55
554
0.99
0.00
4.5
3.5
21.19
48.39
mg/l
2.07
28
357
105
1048
1.00
0.00
10.5
9.9
4.08
4.02
e9/l
0.10
94
912
32
317
1.01
0.00
1.3
1.3
1.13
5.46
u/ml
—
8
131
54
537
1.01
0.00
6.1
4.2
7.39
7.40
ph
0.24
40
395
96
955
1.01
0.00
3.7
3.8
0.00
1.56
estimate
—
7
192
33
332
0.99
0.00
1.9
1.6
—
—
—
0
0
14
135
1.04
0.00
1.8
2.6
—
20.30
—
0
8
12
122
0.98
0.00
1.1
1.3
—
39.90
—
0
7
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
0.00
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
30.21
—
0
8
8
89
0.89
0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
43.38
—
0
5
0
5
0.00
-0.00
0.0
2.8
—
1939.00
—
0
5
0
5
0.00
-0.00
0.0
2.0
—
1.00
—
0
5
0
9
0.00
-0.00
0.0
4.0
—
5.91
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
0.44
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
28.00
—
0
5
0
5
0.00
-0.00
0.0
4.2
—
49.00
—
0
5
0
6
0.00
-0.00
0.0
2.5
—
20.65
—
0
6
0
5
0.00
-0.00
0.0
8.4
—
9.60
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
11.60
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
18
180
1.00
-0.00
4.8
3.5
5.74
5.76
kpa
0.02
18
174
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
195.30
—
0
9

Mortality – FinRegistry

↥

Association

Association between endpoint H8_DISCON and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_DISCON.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: H8_DISCON – Discontinuity and dislocation of ear ossicles

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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