pterygium: A wedge-shaped fibrovascular lesion arising from the bulbar conjunctiva and extending to the cornea. It is caused by chronic exposure to solar ultraviolet radiation, heat, and dust. It may cause severe vision loss. Studies have linked pterygium to neoplastic proliferation and suggest that it may be a stem cell disorder.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1256 |
4. Check minimum number of eventsNone |
1256 |
5. Include endpointsNone |
1256 |
6. Filter based on genotype QC (FinnGen only) |
1069 |
Control definitions (FinnGen only)
- Control exclude
- H7_CONJUNCTIVA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H11
- Name in latin
- Pterygium
Similar endpoints
↥List of similar endpoints to
Pterygium
based on the number of shared cases.
Similar with more cases:
- Other disorders of conjunctiva
- Disorders of conjunctiva
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10019 | 3736 | 6008 |
| Only index persons | 8003 | 3281 | 4722 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.11 | 0.17 |
| Only index persons | 0.16 | 0.12 | 0.18 |
| Median age at first event (years) | |||
| Whole population | 59.38 | 58.25 | 60.83 |
| Only index persons | 58.52 | 56.95 | 59.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1069 | 398 | 671 |
| Unadjusted period prevalence (%) | 0.25 | 0.14 | 0.31 |
| Median age at first event (years) | 62.62 | 58.56 | 65.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1153
- Matched controls
- 11530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
CGE55
NOMESCO Finland
Excision of pterygium with transplanation of conjunctiva
+∞
307.7
310
*
H11.0
ICD-10 Finland
Pterygium
9904.8
307.7
1001
7
CGE50
NOMESCO Finland
Excision of pterygium
+∞
201.1
187
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.7
139.7
764
3412
CG2S4
NOMESCO Finland
Photography of cornea
45.2
100.9
60
14
37299
ICD-8 Finland
Pterygium
+∞
99.4
94
*
3724A
ICD-9 Finland
Disorders of conjunctiva, Pterygium
+∞
93.0
88
*
3402
FHL
Local change removal and plastic (includes pterygium surgery)
+∞
89.8
85
*
S01GX01
ATC
cromoglicic acid; ophthalmic
3.8
63.2
221
669
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.7
60.0
547
2868
CD2S4
NOMESCO Finland
Photography of eye
23.0
54.6
40
18
H04.10
ICD-10 Finland
Dry eye syndrome
3.3
41.2
176
598
CG2T4
NOMESCO Finland
Topography assessment of cornea
12.5
40.3
40
33
XCK10
NOMESCO Finland
Photography of fundus of eye
3.0
37.7
187
692
CFC00
NOMESCO Finland
Excision of lesion of conjunctiva
50.7
36.9
44
9
H16.0
ICD-10 Finland
Corneal ulcer
4.2
32.8
92
234
ZZU10
NOMESCO Finland
Free graft of conjunctiva
+∞
32.4
31
*
H16.9
ICD-10 Finland
Keratitis, unspecified
7.1
27.7
42
61
CF2S4
NOMESCO Finland
Photography of conjunctiva
61.5
26.1
30
5
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.0
23.2
108
382
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.2
23.1
217
1079
Z3229
NOMESCO Finland
Other healthcare associate professional
2.6
22.5
139
571
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
106.9
19.6
21
*
S01XA18
ATC
ciclosporin; ophthalmic
23.0
19.1
27
12
CFD10
NOMESCO Finland
Repair of conjunctiva
96.6
17.6
19
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
16.7
229
1300
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.1
15.4
152
765
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.2
15.1
62
204
S01GX02
ATC
levocabastine; ophthalmic
3.5
14.9
51
149
H02.1
ICD-10 Finland
Ectropion of eyelid
5.8
14.2
26
46
S01BA01
ATC
dexamethasone; ophthalmic
3.6
14.0
47
136
H10.4
ICD-10 Finland
Chronic conjunctivitis
30.4
13.9
18
6
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
11.1
13.5
25
23
F29
ICPC
Eye symptom/complaint other
2.2
13.3
123
601
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.9
13.2
61
215
D31.0
ICD-10 Finland
Benign neoplasm: Conjunctiva
11.2
12.6
23
21
H57.1
ICD-10 Finland
Ocular pain
3.3
12.3
46
143
H01.0
ICD-10 Finland
Blepharitis
2.6
12.3
70
276
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
11.2
12.1
22
20
H17.8
ICD-10 Finland
Other corneal scars and opacities
16.6
11.7
18
11
H11.4
ICD-10 Finland
Other conjunctival vascular disorders and cysts
65.6
11.6
13
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
11.5
752
6283
S01GX05
ATC
lodoxamide; ophthalmic
15.2
11.3
18
12
S01GX08
ATC
ketotifen; ophthalmic
3.7
11.1
35
97
H18.4
ICD-10 Finland
Corneal degeneration
8.9
10.8
22
25
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.2
10.4
91
436
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
32.8
10.3
13
*
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
10.1
380
2792
S01GX09
ATC
olopatadine; ophthalmic
4.3
9.4
24
57
H17.1
ICD-10 Finland
Other central corneal opacity
14.2
8.7
14
10
F01
ICPC
Eye pain
3.2
8.7
34
109
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
50.4
8.7
10
*
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
6.7
8.7
21
32
H25.0
ICD-10 Finland
Senile incipient cataract
2.0
8.5
89
457
CFA20
NOMESCO Finland
Biopsy of conjunctiva
20.2
8.5
12
6
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.7
8.4
189
1224
H11.8
ICD-10 Finland
Other specified disorders of conjunctiva
22.2
8.0
11
5
CGE10
NOMESCO Finland
Keratectomy
22.2
8.0
11
5
WX140
NOMESCO Finland
Parabulbar anesthesy
2.1
7.8
70
339
S29
ICPC
Skin symptom/complaint other
1.6
7.6
215
1469
WX002
NOMESCO Finland
Sedation and analgesia
1.6
7.6
222
1530
H52.2
ICD-10 Finland
Astigmatism
3.6
7.4
24
68
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
80.6
7.4
8
*
A98
ICPC
Health maint/preventive medicine
1.8
7.4
1048
9784
S01BA07
ATC
fluorometholone; ophthalmic
4.1
7.4
20
50
F73
ICPC
Eye infection/inflammation other
3.5
7.3
24
69
H10.5
ICD-10 Finland
Blepharoconjunctivitis
4.3
7.2
18
42
L01
ICPC
Neck symptom/complaint
1.7
7.2
152
969
H10.8
ICD-10 Finland
Other conjunctivitis
8.3
6.8
14
17
G44.2
ICD-10 Finland
Tension-type headache
1.7
6.8
121
736
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.2
6.8
54
250
R42
ICD-10 Finland
Dizziness and giddiness
1.5
6.7
257
1870
ZXA00
NOMESCO Finland
Right side
1.4
6.7
302
2268
H18.8
ICD-10 Finland
Other specified disorders of cornea
7.2
6.7
15
21
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.4
6.7
414
3292
ZXA10
NOMESCO Finland
Bilateral
1.5
6.7
208
1452
H11.3
ICD-10 Finland
Conjunctival haemorrhage
2.5
6.7
41
169
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
4.0
6.6
18
45
L20
ICD-10 Finland
Atopic dermatitis
3.6
6.6
21
59
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
6.6
295
2214
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.1
6.4
62
310
XCH00
NOMESCO Finland
Eye pressure measurement
2.1
6.3
62
311
3401
FHL
Removal of local modification or taking a specimen in the operating room
+∞
6.3
6
*
XCX10
NOMESCO Finland
Other photography of eye
26.8
6.2
8
*
S01AA01
ATC
chloramphenicol; ophthalmic
2.2
6.2
50
233
S01GX04
ATC
nedocromil; ophthalmic
6.3
6.2
15
24
S01KA02
ATC
hypromellose; ophthalmic
3.6
6.1
19
53
H25.8
ICD-10 Finland
Other senile cataract
1.6
6.0
141
921
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1044
9703
1.80
7.95
21.2
23.1
3.99
4.01
mmol/l
1.62
1016
9503
1068
10008
1.91
7.73
26.7
28.3
91.28
91.72
fl
2.52
1055
9878
1068
10010
1.91
7.70
26.7
28.4
4.44
4.43
e12/l
0.47
1038
9764
1068
10012
1.91
7.66
27.0
28.6
133.84
133.88
g/l
0.03
1055
9882
1059
9904
1.85
7.62
23.7
25.0
83.08
83.90
umol/l
0.23
1047
9779
1067
10008
1.89
7.52
26.8
28.4
241.51
241.20
e9/l
0.06
1039
9793
1067
10010
1.88
7.49
27.1
29.0
39.64
39.95
%
0.81
1054
9873
1067
10012
1.88
7.45
26.8
28.4
6.77
6.88
e9/l
0.49
1036
9765
1040
9687
1.75
7.42
21.0
22.9
139.59
139.66
mmol/l
0.38
1016
9499
1044
9776
1.72
6.76
12.9
13.0
25.81
25.58
u/l
0.12
1006
9466
989
9162
1.56
6.41
5.8
5.6
5.94
6.08
mmol/l
2.88
889
8302
999
9304
1.55
6.01
18.0
18.8
23.69
27.49
mg/l
3.12
828
7856
807
7240
1.38
5.82
5.1
4.5
12.78
13.76
mm/h
1.09
745
6707
980
9130
1.49
5.46
5.7
5.3
1.49
1.42
mmol/l
5.37
899
8360
967
8988
1.47
5.42
6.8
7.1
40.20
40.18
mmol/mol
0.01
881
8326
985
9191
1.49
5.39
5.8
5.4
4.56
4.44
mmol/l
3.19
910
8491
1001
9383
1.51
5.23
6.6
6.2
2.63
2.56
mmol/l
1.56
920
8617
787
7095
1.34
5.08
4.0
4.0
14.87
14.97
pmol/l
0.51
697
6417
967
9032
1.44
4.86
18.0
18.5
76.99
75.76
ml/min/173m2
1.23
905
8442
931
8642
1.40
4.81
5.2
5.1
2.18
2.03
mu/l
0.47
839
7861
604
5293
1.30
4.52
3.9
4.1
0.00
0.01
estimate
1.46
147
1095
842
7730
1.33
4.40
7.9
8.7
83.67
81.52
u/l
0.35
802
7331
590
5196
1.28
4.09
3.9
4.1
0.00
0.00
estimate
-0.00
152
1146
60
351
1.75
3.95
1.0
1.0
—
—
—
0
0
333
2739
1.30
3.91
3.5
3.7
0.09
0.02
estimate
0.96
117
892
595
5273
1.27
3.81
3.9
4.1
0.01
1.20
estimate
0.50
154
1176
932
8745
1.34
3.77
4.8
4.5
1.21
1.27
mmol/l
2.38
841
7950
732
6655
1.27
3.76
5.1
4.9
29.14
1877.77
e6/l
2.26
14
118
819
7558
1.29
3.69
21.2
23.4
13.66
13.84
%
3.59
809
7458
22
91
2.45
3.65
1.0
1.3
—
—
—
0
0
455
3922
1.26
3.63
2.1
2.0
1.20
1.32
mmol/l
3.42
364
3213
221
1733
1.34
3.61
1.5
1.5
2.60
2.69
g/l
0.20
126
1038
104
1474
0.68
3.57
7.3
8.0
1.32
0.86
mmol/l
0.82
95
1203
50
828
0.59
3.44
8.9
9.6
1.16
1.31
%
0.57
50
821
484
4246
1.24
3.20
4.9
4.3
54.41
82.88
ng/l
0.60
365
3338
51
819
0.61
3.13
8.8
9.9
94.69
93.88
%
0.73
51
813
44
254
1.76
3.09
1.2
1.3
1.64
6.68
u/ml
—
5
40
22
100
2.22
3.01
1.0
1.1
0.45
1.30
u/ml
0.87
13
45
239
1944
1.29
2.98
1.3
1.3
1.68
1.63
u/ml
0.02
58
542
16
345
0.46
2.61
3.3
4.2
4.02
3.95
mmol/l
0.12
16
340
52
794
0.64
2.60
8.6
10.0
0.63
0.64
%
0.12
52
788
134
1025
1.35
2.59
2.2
2.3
150.02
138.38
ug/g
0.15
104
821
14
56
2.52
2.53
1.0
1.0
0.04
0.97
u/ml
—
5
14
41
248
1.68
2.49
1.8
2.1
9.31
13.07
mg/l
2.24
36
228
519
4679
1.20
2.41
6.7
6.1
5.44
2.99
ug/l
0.55
462
4183
80
1101
0.71
2.37
2.0
2.4
0.21
0.20
g/l
0.12
70
1030
409
3620
1.20
2.29
3.5
3.6
90.28
99.06
e6/l
0.06
320
2829
198
1625
1.26
2.29
1.4
1.3
38.66
37.61
iu/ml
0.04
54
504
438
3909
1.19
2.23
4.0
4.2
0.05
0.02
estimate
0.35
131
966
33
197
1.70
2.14
1.2
1.1
5.38
7.01
eliau/ml
—
8
16
18
88
2.06
2.12
1.8
1.6
26.86
26.77
u/ml
—
7
13
46
301
1.55
2.08
1.5
1.6
0.78
23.66
iu/ml
—
6
51
116
900
1.32
2.07
5.2
4.2
1.22
1.22
mmol/l
0.10
104
772
58
402
1.47
2.02
1.6
2.1
34.31
38.99
u/l
1.25
51
350
620
5741
1.17
1.96
8.2
9.7
4.11
4.26
e9/l
0.74
538
4981
55
380
1.47
1.95
1.5
1.8
2.38
9.78
iu/ml
—
8
89
382
3405
1.18
1.92
2.4
2.3
169.93
257.15
u/l
1.82
361
3234
7
22
3.19
1.88
1.3
1.0
—
—
—
0
0
579
5349
1.17
1.85
15.9
18.2
1.27
1.32
inr
1.61
493
4528
45
305
1.49
1.77
1.4
1.5
332.70
269.43
ug/g
0.98
23
191
528
4858
1.16
1.75
2.2
2.3
95.42
94.38
pmol/l
0.17
283
2659
78
587
1.35
1.74
2.6
2.6
12.78
20.10
au/ml
—
9
42
9
36
2.51
1.74
1.9
2.1
3.01
7.11
nmol/l
—
9
29
33
211
1.58
1.69
1.2
1.3
—
532.00
—
0
5
316
2802
1.18
1.67
2.6
2.9
346.61
357.96
umol/l
1.12
266
2446
346
3095
1.17
1.63
3.5
3.5
0.30
0.47
e6/l
1.55
262
2344
74
561
1.34
1.59
3.3
3.9
1.02
1.02
ratio
0.41
66
524
39
265
1.49
1.55
1.7
1.6
—
—
—
0
0
7
27
2.60
1.51
1.4
1.9
119.24
81.26
nmol/24h
—
7
27
25
154
1.64
1.51
1.4
1.6
—
—
—
0
0
6
21
2.87
1.50
2.0
2.5
—
—
—
0
0
73
558
1.33
1.50
1.3
1.2
302.11
214.04
u/ml
0.44
68
510
22
131
1.69
1.50
1.8
2.4
38.22
20.90
mg/l
—
9
50
480
4425
1.15
1.48
2.5
2.4
81.54
78.27
nmol/l
1.63
423
3935
253
2227
1.17
1.45
2.7
3.1
2.45
2.46
mmol/l
0.38
224
2002
522
4846
1.14
1.44
4.1
5.3
35.24
34.86
g/l
0.83
470
4538
61
457
1.35
1.44
2.3
1.9
—
—
—
0
0
207
1793
1.19
1.44
3.5
3.3
2.07
1.53
e6/l
0.27
115
961
6
22
2.74
1.43
1.0
1.2
0.30
0.27
g/l
—
6
17
6
23
2.62
1.37
2.0
2.4
—
—
—
0
0
10
47
2.14
1.34
2.0
2.6
696.30
1503.74
u/ml
—
10
47
0
41
0.00
1.31
0.0
5.7
—
71.23
—
0
35
5
18
2.79
1.28
5.2
8.7
8.76
10.32
%
—
5
18
35
245
1.44
1.24
3.8
3.9
33.30
29.86
mg/l
0.21
27
170
302
2726
1.15
1.24
4.0
3.5
0.86
0.80
ug/l
0.56
227
1923
8
36
2.23
1.24
1.0
1.4
—
—
—
0
0
332
3018
1.14
1.23
2.2
2.3
2.74
2.93
mg/l
0.69
282
2602
11
56
1.97
1.22
1.1
2.3
—
—
—
0
0
56
427
1.33
1.21
2.4
1.7
—
—
—
0
0
12
64
1.88
1.18
1.2
1.2
68.17
91.56
u/l
0.68
12
57
12
64
1.88
1.18
1.2
1.2
15.58
28.43
u/l
0.86
12
56
92
1115
0.81
1.16
7.3
7.3
9.23
11.07
mmol/l
1.57
85
1069
5
20
2.51
1.15
1.4
1.6
—
—
—
0
0
362
3323
1.13
1.15
1.7
1.8
19.94
19.88
nmol/l
0.02
306
2798
240
2145
1.15
1.14
1.8
1.6
1.74
1.48
mg/l
0.26
187
1708
476
4446
1.12
1.12
3.0
3.1
148.20
150.47
ug/l
0.05
427
4096
129
1098
1.20
1.12
1.3
1.4
—
—
—
0
0
661
6293
1.12
1.10
4.6
5.4
6.84
6.84
mmol/l
0.01
632
6030
29
201
1.45
1.10
3.5
1.6
—
—
—
0
0
5
21
2.39
1.09
5.2
7.9
4.60
5.16
kpa
—
5
21
12
66
1.83
1.09
2.7
2.5
—
—
—
0
0
12
66
1.83
1.09
1.1
1.2
—
—
—
0
0
639
6075
1.12
1.09
3.3
3.4
49.89
55.46
u/l
0.84
595
5655
54
418
1.31
1.08
2.4
1.8
—
—
—
0
0
11
59
1.87
1.07
1.0
1.2
—
—
—
0
0
34
464
0.72
1.06
3.5
3.6
48.83
3277.16
u/ml
0.87
29
397
10
52
1.93
1.06
1.2
1.5
—
—
—
0
0
14
82
1.72
1.05
1.1
1.2
—
—
—
0
0
12
67
1.80
1.05
1.1
1.2
—
—
—
0
0
15
90
1.68
1.04
1.2
1.1
8.96
2.20
eliau/ml
—
8
36
241
2668
0.88
1.04
2.4
2.6
—
—
—
0
0
13
75
1.74
1.03
1.1
1.2
—
—
—
0
0
400
3716
1.12
1.02
3.4
3.3
1302.16
1627.89
ng/l
1.59
344
3250
172
1514
1.16
1.01
1.4
1.3
7.51
12.76
u/ml
0.55
49
536
34
248
1.38
1.00
1.3
1.3
—
—
—
0
0
0
30
0.00
0.97
0.0
1.4
—
11.17
—
0
30
7
36
1.95
0.97
1.7
1.5
—
—
—
0
0
10
174
0.57
0.97
1.2
1.1
—
—
—
0
0
12
69
1.75
0.96
1.1
1.2
—
—
—
0
0
12
69
1.75
0.96
1.1
1.2
—
—
—
0
0
9
51
1.77
0.94
1.2
1.0
—
—
—
0
0
7
37
1.90
0.94
1.0
1.1
—
—
—
0
0
9
52
1.74
0.92
1.2
1.1
—
—
—
0
0
58
466
1.26
0.90
2.4
1.7
—
—
—
0
0
39
297
1.32
0.90
1.6
1.6
12.39
18.19
u/ml
—
7
63
171
1917
0.87
0.90
2.8
3.3
0.83
0.82
mmol/l
0.65
155
1808
277
2539
1.12
0.89
2.6
2.8
3.71
4.60
e6/l
0.92
254
2325
581
5534
1.10
0.89
6.6
7.8
1.21
1.21
mmol/l
1.68
509
4775
213
1923
1.13
0.88
3.6
3.2
0.72
1.07
e6/l
1.92
120
1089
8
42
1.91
0.88
1.1
1.0
638.00
1568.21
miu/ml
—
8
42
8
42
1.91
0.88
1.1
1.1
—
—
—
0
0
24
169
1.43
0.88
3.3
1.5
—
—
—
0
0
237
2157
1.12
0.86
4.3
4.1
803.66
357.31
ng/l
0.70
204
1818
400
3747
1.10
0.86
5.6
4.9
23.07
21.58
%
1.30
238
2006
30
222
1.36
0.84
1.4
1.5
—
—
—
0
0
147
1300
1.15
0.83
5.9
5.1
32.07
32.62
%
0.27
98
852
130
1476
0.87
0.82
1.9
1.9
—
—
—
0
0
34
259
1.32
0.80
1.4
1.5
—
—
—
0
0
13
82
1.59
0.78
1.3
1.5
—
—
—
0
0
106
922
1.16
0.76
2.4
2.3
12.20
12.81
nmol/l
0.27
91
821
390
3674
1.09
0.73
3.1
3.6
2.35
2.35
mmol/l
0.14
342
3327
464
4870
0.92
0.70
2.8
3.0
—
—
estimate
—
0
0
21
284
0.73
0.68
1.7
1.7
10.03
3.97
mg/l
0.57
14
219
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
34
429
0.79
0.68
2.8
2.6
0.28
0.37
iu/ml
1.04
22
234
584
5616
1.08
0.66
5.8
7.0
11.31
12.23
umol/l
1.69
550
5368
102
899
1.15
0.64
1.6
1.4
—
—
—
0
0
64
749
0.85
0.63
7.0
8.5
25.28
24.70
mmol/l
0.82
64
744
109
1225
0.88
0.63
2.1
2.9
8.79
9.20
umol/l
0.11
87
1092
142
1569
0.89
0.62
1.8
1.8
—
—
—
0
0
14
96
1.46
0.61
1.9
1.7
—
—
—
0
0
14
96
1.46
0.61
1.9
2.0
4.00
1.80
u/field
—
8
49
131
1179
1.13
0.61
3.6
3.7
—
—
—
0
0
9
137
0.65
0.61
1.0
1.1
—
—
—
0
0
8
51
1.57
0.60
1.6
1.5
—
—
—
0
0
43
354
1.22
0.59
1.3
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.4
—
78.93
—
0
14
59
502
1.18
0.59
2.8
3.5
4.38
4.44
pmol/l
0.16
51
447
0
23
0.00
0.58
0.0
2.2
—
78.67
—
0
15
322
3039
1.08
0.58
3.9
4.2
0.01
0.00
estimate
0.14
129
1039
15
106
1.42
0.57
1.1
1.4
—
—
—
0
0
108
1205
0.89
0.57
7.1
7.9
—
—
—
0
0
11
73
1.51
0.56
1.5
1.2
1.67
1.98
mmol/l
1.95
11
66
59
507
1.17
0.53
2.3
2.6
3.46
3.75
g/l
0.97
53
468
9
62
1.46
0.53
2.2
3.6
13.27
13.23
%
—
9
62
59
508
1.17
0.52
2.3
2.6
7.17
7.34
g/l
0.29
53
468
59
508
1.17
0.52
2.3
2.6
4.25
4.18
g/l
0.32
53
469
19
144
1.32
0.50
1.6
1.7
—
—
—
0
0
16
118
1.36
0.50
3.3
2.8
—
—
—
0
0
21
162
1.30
0.50
1.5
1.5
—
—
—
0
0
53
615
0.86
0.50
1.4
1.8
1.41
1.53
g/l
0.51
41
544
23
180
1.28
0.50
1.3
1.3
—
—
—
0
0
23
289
0.79
0.48
1.6
1.6
12412.53
15928.61
e6/l
0.17
15
204
12
166
0.72
0.48
1.2
1.3
20073.29
80960.48
e6/l
—
7
91
105
950
1.12
0.47
2.3
2.2
371.57
381.41
nmol/l
0.17
95
888
21
266
0.79
0.47
1.8
2.5
37.43
116.30
ug/min
1.37
11
164
22
276
0.79
0.46
1.6
1.5
—
—
—
0
0
7
49
1.43
0.46
1.3
1.1
—
—
—
0
0
117
1068
1.11
0.45
3.0
2.9
66.72
66.37
g/l
0.22
108
988
87
966
0.89
0.45
1.4
1.8
1.56
1.58
%
0.11
81
814
10
69
1.45
0.44
1.4
1.6
—
—
—
0
0
51
442
1.16
0.44
2.8
2.7
9.10
10.80
g/l
2.70
44
401
51
442
1.16
0.44
2.4
2.7
0.59
1.46
g/l
1.32
41
390
18
139
1.30
0.43
1.1
1.4
—
—
—
0
0
13
95
1.37
0.43
1.3
1.7
—
—
—
0
0
77
859
0.89
0.43
2.5
3.2
62.50
61.04
ml/min/173m2
0.15
34
380
72
806
0.89
0.43
1.5
1.4
—
—
—
0
0
8
56
1.43
0.42
1.3
1.7
—
—
—
0
0
8
56
1.43
0.42
1.3
1.7
—
—
—
0
0
8
56
1.43
0.42
1.3
1.7
—
—
—
0
0
8
56
1.43
0.42
1.3
1.7
—
—
—
0
0
216
2036
1.07
0.42
1.7
1.8
1028.79
1164.35
nmol/l
1.80
162
1563
32
380
0.84
0.41
1.1
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
8.4
—
5.32
—
0
16
35
296
1.19
0.41
1.8
2.4
131.30
129.11
g/l
0.15
27
238
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
18
141
1.28
0.40
1.2
1.5
—
—
—
0
0
50
570
0.87
0.40
1.9
1.9
1.88
1.86
ug/l
0.01
43
508
368
3825
0.94
0.39
3.1
3.5
7.25
7.55
mmol/l
0.70
305
3235
27
224
1.21
0.38
1.4
1.5
—
—
—
0
0
15
116
1.30
0.37
2.4
1.8
3273.88
949.87
u/l
—
5
41
10
72
1.39
0.37
1.4
1.6
—
—
—
0
0
10
72
1.39
0.37
1.0
1.2
—
—
—
0
0
9
70
1.29
0.36
2.6
3.2
22.44
59.13
u/ml
—
9
70
24
199
1.21
0.35
1.3
1.4
1.45
0.84
nmol/l
0.47
19
165
6
44
1.37
0.34
2.7
2.2
56.83
45.03
umol/l
—
6
37
54
482
1.13
0.33
1.7
1.8
3.22
3.45
mmol/l
0.72
33
360
346
3337
1.05
0.33
2.8
2.7
58.90
85.57
u/l
0.57
309
3106
6
46
1.31
0.33
1.0
1.0
—
—
—
0
0
195
1850
1.07
0.33
2.7
2.7
2.31
2.25
g/l
0.74
175
1713
25
210
1.19
0.33
1.8
1.3
—
—
—
0
0
17
137
1.24
0.32
1.2
1.5
—
—
—
0
0
17
137
1.24
0.32
1.2
1.5
—
—
—
0
0
13
101
1.29
0.31
1.2
1.3
—
—
—
0
0
33
286
1.16
0.31
1.1
1.3
—
—
—
0
0
17
138
1.24
0.30
1.2
1.5
—
—
—
0
0
371
3828
0.95
0.30
3.8
4.2
4.09
8.43
mg/mmol
4.23
227
2509
7
55
1.27
0.30
1.1
1.0
—
—
—
0
0
55
608
0.90
0.29
1.4
1.5
—
—
—
0
0
257
2672
0.95
0.28
3.6
4.3
84.76
85.07
%
0.07
252
2620
19
226
0.84
0.27
1.6
1.3
5.43
35.84
e6/l
0.65
14
165
9
117
0.77
0.27
1.0
1.2
24.00
12.71
u/l
—
9
105
8
64
1.25
0.27
4.1
3.9
—
—
—
0
0
114
1213
0.93
0.27
3.8
3.7
1.70
1.86
mmol/l
0.18
103
1026
96
1028
0.93
0.27
3.9
2.5
8.63
7.08
ug/l
0.34
79
921
45
404
1.12
0.27
2.4
3.6
1.86
4.43
ratio
1.14
25
238
23
196
1.18
0.27
1.3
1.4
—
—
—
0
0
22
187
1.18
0.26
1.3
1.5
—
—
—
0
0
181
1728
1.06
0.26
2.8
2.7
20.76
22.54
%
1.14
163
1612
5
72
0.69
0.26
1.0
1.2
—
79.80
—
0
5
34
301
1.13
0.25
1.6
1.6
—
—
—
0
0
25
216
1.16
0.25
1.4
1.3
—
—
—
0
0
25
216
1.16
0.25
1.4
1.3
—
—
—
0
0
501
4904
1.04
0.25
2.7
2.5
—
—
—
0
0
22
189
1.17
0.24
2.5
1.7
257.73
291.89
mu/l
0.41
22
177
15
179
0.84
0.23
1.1
1.2
1.48
1.53
g/l
0.27
15
179
10
125
0.80
0.23
1.4
1.9
—
—
—
0
0
78
832
0.93
0.21
1.4
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
3.6
—
70.88
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
20
173
1.16
0.21
1.3
1.2
245.38
254.81
u/ml
0.06
13
93
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
42
459
0.91
0.20
2.7
2.8
—
—
—
0
0
0
14
0.00
0.20
0.0
6.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
102.00
—
0
14
6
53
1.13
0.18
3.3
1.7
5.35
8.88
u/l
—
6
45
6
53
1.13
0.18
1.5
1.8
—
—
—
0
0
17
196
0.87
0.18
1.2
1.3
0.88
0.91
g/l
0.17
17
196
20
175
1.15
0.18
1.2
1.3
85.96
205.65
miu/ml
—
9
65
24
269
0.89
0.18
3.5
3.4
0.88
0.83
nmol/l
0.33
17
217
7
59
1.19
0.18
1.0
1.5
73.43
89.92
umol/l
—
7
59
338
3306
1.03
0.17
3.1
3.4
35.15
34.91
u/l
0.02
319
3121
26
289
0.90
0.17
3.7
3.8
8.15
1.97
index
0.42
13
163
34
310
1.10
0.17
1.5
1.7
—
—
—
0
0
76
803
0.94
0.17
1.6
1.7
—
—
—
0
0
23
205
1.12
0.17
1.6
1.9
3.07
4.16
iu/l
—
9
81
204
1980
1.04
0.16
2.7
2.7
12.01
12.53
umol/l
0.55
185
1846
93
975
0.95
0.16
4.0
3.0
250.99
231.10
ng/l
0.16
88
901
154
1594
0.96
0.16
5.3
5.8
1.00
1.03
mmol/l
0.64
139
1488
48
448
1.07
0.15
2.5
3.8
36.54
66.64
mg/l
1.25
40
383
31
338
0.91
0.15
1.6
1.8
—
—
—
0
0
7
87
0.80
0.14
1.0
1.1
—
—
—
0
0
7
88
0.79
0.14
1.0
1.1
289.43
294.23
mg/l
—
7
78
16
141
1.14
0.14
1.1
1.5
—
—
—
0
0
33
305
1.08
0.13
1.4
1.3
—
—
—
0
0
50
471
1.06
0.13
2.4
2.6
2.91
2.93
g/l
0.02
43
432
15
132
1.14
0.13
2.4
3.6
—
—
—
0
0
21
231
0.91
0.12
1.1
1.2
3.84
3.76
mmol/l
0.15
21
214
10
116
0.86
0.12
1.4
1.9
—
—
—
0
0
82
853
0.96
0.11
2.8
4.0
91.80
97.22
ng/l
0.19
70
743
40
376
1.07
0.11
2.4
2.6
0.00
0.03
g/l
1.14
34
341
237
2324
1.02
0.11
4.1
4.3
6.85
1.02
kg/l
0.50
173
1578
12
105
1.14
0.11
1.0
1.1
—
—
—
0
0
5
44
1.14
0.10
2.0
1.2
—
76.00
%
—
0
6
5
44
1.14
0.10
1.4
1.8
—
—
—
0
0
5
44
1.14
0.10
1.4
1.8
—
—
—
0
0
5
45
1.11
0.10
1.4
1.8
—
—
—
0
0
96
990
0.97
0.09
2.2
2.4
29.50
36.69
u/l
2.74
88
821
47
448
1.05
0.09
2.5
3.8
21.67
104.62
mg/l
1.63
39
385
502
4974
1.02
0.09
5.7
7.1
1.21
1.21
mmol/l
0.86
466
4608
6
55
1.09
0.09
1.2
1.4
—
—
—
0
0
6
55
1.09
0.09
1.2
1.4
—
—
—
0
0
240
2363
1.02
0.08
1.9
1.8
424.61
25521523.93
pmol/l
1.93
185
1967
5
62
0.81
0.08
3.8
2.2
—
—
—
0
0
5
64
0.78
0.08
1.0
1.3
—
—
—
0
0
5
64
0.78
0.08
1.0
1.2
—
—
—
0
0
6
74
0.81
0.07
1.0
1.9
—
—
—
0
0
8
74
1.08
0.07
1.1
1.4
—
—
—
0
0
8
74
1.08
0.07
1.1
1.4
—
—
—
0
0
8
78
1.03
0.07
1.3
1.0
—
—
—
0
0
69
711
0.97
0.07
3.3
3.6
1.57
1.88
mmol/l
0.29
54
527
25
265
0.94
0.07
1.4
1.6
—
—
—
0
0
8
93
0.86
0.06
1.3
1.1
—
—
—
0
0
36
376
0.96
0.06
1.4
1.7
0.38
0.34
mg/l
0.13
15
176
9
105
0.86
0.06
1.2
1.1
—
—
—
0
0
10
111
0.90
0.06
2.2
1.3
—
—
—
0
0
124
1260
0.98
0.05
3.3
4.3
28.88
24.92
ug/l
0.06
96
1053
14
130
1.08
0.04
1.1
1.1
—
—
—
0
0
24
251
0.96
0.04
1.3
1.3
—
—
—
0
0
82
831
0.99
0.02
3.5
3.8
5.11
5.14
kpa
0.10
77
801
11
103
1.07
0.02
1.5
1.3
10.55
14.09
u/l
2.43
11
95
207
2078
1.00
0.01
2.0
1.9
—
—
—
0
0
68
673
1.01
0.01
2.3
2.1
3.49
3.48
ratio
0.01
50
550
11
104
1.06
0.01
1.0
1.1
129.45
110.79
%
0.83
11
98
20
206
0.97
0.00
1.7
1.8
—
—
—
0
0
50
494
1.01
0.00
1.0
1.2
132.35
144.26
u/ml
0.07
16
188
26
256
1.02
0.00
1.2
1.2
—
—
—
0
0
10
102
0.98
0.00
1.6
1.6
—
—
—
0
0
10
102
0.98
0.00
1.6
1.6
—
—
—
0
0
10
102
0.98
0.00
1.6
1.6
—
—
—
0
0
31
308
1.01
0.00
1.6
1.7
—
—
—
0
0
14
137
1.02
0.00
1.7
2.5
1.13
0.42
mmol/l
0.32
14
131
16
157
1.02
0.00
1.6
1.7
—
—
—
0
0
37
367
1.01
0.00
2.5
2.7
0.00
0.00
g/l
-0.00
31
322
26
255
1.02
0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.7
—
—
—
0
0
11
110
1.00
-0.00
1.5
1.6
23.97
38.70
ng/l
0.64
11
110
6
60
1.00
-0.00
12.5
3.6
1.00
1.18
%
—
6
60
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
6
61
0.98
-0.00
1.7
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.3
173.40
416.42
u/l
—
5
48
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
77
0.91
-0.00
1.4
1.1
108.43
99.78
pmol/l
—
7
77
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
61
0.98
-0.00
1.7
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
26.75
—
0
8
6
69
0.87
-0.00
1.0
1.7
50.42
102.85
ng/l
—
6
69
6
62
0.97
-0.00
1.2
1.1
293.00
289.66
mg/l
—
6
56
5
51
0.98
-0.00
1.6
1.6
45.00
39.94
g/l
—
5
51
6
65
0.92
-0.00
1.2
1.1
40.42
44.57
mg/l
—
6
56
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_PTERYGIUM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PTERYGIUM | 0.801 [0.69, 0.92] | 0.002 |
| Birth year | 0.993 [0.98, 1.0] | 0.096 |
During the follow-up period (1.1.1998 — 31.12.2019), 305 out of 2393 females with H7_PTERYGIUM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PTERYGIUM | 0.781 [0.7, 0.87] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.137 |
During the follow-up period (1.1.1998 — 31.12.2019), 750 out of 3406 males with H7_PTERYGIUM died.
Mortality risk
Mortality risk for people of age
years, who have H7_PTERYGIUM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.067% | 0.156% |
| 5 | 0.458% | 1.033% |
| 10 | 1.213% | 2.673% |
| 15 | 2.145% | 5.331% |
| 20 | 3.639% | 9.071% |
Relationships between endpoints
↥Index endpoint: H7_PTERYGIUM – Pterygium
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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