No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
436 |
4. Check minimum number of eventsNone |
436 |
5. Include endpointsNone |
436 |
6. Filter based on genotype QC (FinnGen only) |
392 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H05
- Name in latin
- Exophthalmus
Similar endpoints
↥List of similar endpoints to
Exophthalmic conditions
based on the number of shared cases.
Similar with more cases:
- Disorders of orbit
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2738 | 1729 | 982 |
| Only index persons | 2452 | 1594 | 858 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 55.09 | 55.33 | 54.47 |
| Only index persons | 54.37 | 54.68 | 53.79 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 392 | 253 | 139 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.06 |
| Median age at first event (years) | 53.72 | 53.06 | 54.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 409
- Matched controls
- 4090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
307.7
382
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
34.3
167.5
113
45
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
99.1
91
*
H03BB01
ATC
carbimazole; oral
17.0
98.6
89
66
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
18.3
76.0
64
41
H03AA01
ATC
levothyroxine sodium; systemic
4.7
51.4
190
643
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.7
49.5
275
1248
H53.2
ICD-10 Finland
Diplopia
10.0
46.9
57
65
XCK00
NOMESCO Finland
Perimetry
7.8
46.1
70
105
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
172.2
44.8
46
*
104
Kela drug reimbursment
Thyroid insufficiency
6.6
43.8
80
146
H04.10
ICD-10 Finland
Dry eye syndrome
6.4
42.1
79
148
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.4
41.3
139
428
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
10.5
35.6
41
43
H062, E050,
ICD-10 Finland
+∞
32.7
31
*
BAA60
NOMESCO Finland
Total thyroidectomy
9.7
32.1
39
44
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
31.7
30
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
12.3
30.4
31
27
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
28.5
27
*
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
49.4
26.9
32
7
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.3
26.3
77
208
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.6
26.2
70
176
CAA30
NOMESCO Finland
Biopsy of orbit
243.0
22.9
23
*
XCK10
NOMESCO Finland
Photography of fundus of eye
4.1
22.2
68
189
E03.89
ICD-10 Finland
Other specified hypothyroidism
6.0
21.8
40
72
H02.3
ICD-10 Finland
Blepharochalasis
23.0
21.1
30
14
H02.4
ICD-10 Finland
Ptosis of eyelid
32.0
20.8
27
9
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
220.8
20.8
21
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
5.9
19.7
37
68
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.3
18.5
28
41
H50.2
ICD-10 Finland
Vertical strabismus
26.5
18.4
25
10
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.1
17.7
89
339
H02AB06
ATC
prednisolone; systemic
2.5
17.6
238
1476
3763A
ICD-9 Finland
Disorders of the orbit, Other exophthalmic conditions
+∞
16.8
16
*
H05.1
ICD-10 Finland
Chronic inflammatory disorders of orbit
+∞
16.8
16
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
16.5
184
1038
H02AB07
ATC
prednisone; oral
3.0
16.3
85
330
H02AB09
ATC
hydrocortisone; systemic
7.6
15.8
23
32
3762A
ICD-9 Finland
Disorders of the orbit, Endocrine exophthalmos
+∞
14.7
14
*
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
15.2
14.2
23
16
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
55.3
13.9
16
*
A02BC02
ATC
pantoprazole; systemic
2.5
13.7
312
2315
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
13.6
13
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
16.9
13.6
21
13
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.2
13.5
163
933
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
13.4
176
1043
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
13.3
126
651
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
41.5
13.2
16
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
12.1
170
1023
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
11.7
111
570
UDM02
NOMESCO Finland
Sinoscopy
5.9
11.6
21
37
Z3231
NOMESCO Finland
Registered nurse
2.1
10.7
128
718
AA1AD
NOMESCO Finland
CT of head and brain
2.1
10.7
136
781
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
10.5
10
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
+∞
10.5
10
*
H02AB04
ATC
methylprednisolone; systemic
2.5
10.3
75
341
CS494
NOMESCO Finland
Other visual field testing
5.5
10.2
20
38
ZXA10
NOMESCO Finland
Bilateral
2.3
10.1
89
440
WX002
NOMESCO Finland
Sedation and analgesia
2.3
9.9
89
443
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
20.6
9.9
14
7
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
9.8
213
1468
CAC44
NOMESCO Finland
Combined decompression of orbit
102.3
9.5
10
*
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
102.3
9.5
10
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
11.0
9.4
17
16
H57.1
ICD-10 Finland
Ocular pain
4.1
9.3
26
67
CEC00
NOMESCO Finland
Recession of extraocular muscle
37.6
9.1
11
*
CD2S4
NOMESCO Finland
Photography of eye
24.7
9.0
12
5
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.0
8.8
25
65
WX892
NOMESCO Finland
Monitored bed care
3.0
8.8
39
137
CA1BD
NOMESCO Finland
Extensive orbita CT
51.1
8.7
10
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.2
8.7
36
121
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
8.7
74
360
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
11.9
8.6
15
13
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.6
8.4
50
205
WF002
NOMESCO Finland
Radical radiotherapy
3.6
8.4
28
82
ZXE20
NOMESCO Finland
More than three and less than five hours
2.4
8.4
65
303
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.2
8.4
22
54
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
8.4
8
*
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
8.4
8
*
H02.2
ICD-10 Finland
Lagophthalmos
+∞
8.4
8
*
H02.1
ICD-10 Finland
Ectropion of eyelid
+∞
8.4
8
*
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
8.4
8
*
R03BB04
ATC
tiotropium bromide; inhalant
2.6
8.1
50
209
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
8.0
70
343
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
7.8
115
686
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
7.8
90
493
H10.4
ICD-10 Finland
Chronic conjunctivitis
15.4
7.8
12
8
CA1AD
NOMESCO Finland
Orbita CT
45.9
7.7
9
*
ZXE00
NOMESCO Finland
One hour or less
1.8
7.7
164
1099
A04
ICPC
Weakness/tiredness general
2.2
7.7
71
356
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.3
7.6
61
289
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
81.5
7.4
8
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
13.7
7.4
12
9
H01.0
ICD-10 Finland
Blepharitis
3.2
7.3
29
95
CBB20
NOMESCO Finland
Correction of lax skin of eyelid and resection of herniated fat
+∞
7.3
7
*
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
+∞
7.3
7
*
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
+∞
7.3
7
*
H05.8
ICD-10 Finland
Other disorders of orbit
+∞
7.3
7
*
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
+∞
7.3
7
*
Z3229
NOMESCO Finland
Other healthcare associate professional
2.7
7.3
40
158
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
12.3
7.1
12
10
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
7.0
125
789
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
3.1
7.0
29
98
WX110
NOMESCO Finland
Infiltration anesthesia
1.8
6.9
293
2374
S01KA02
ATC
hypromellose; ophthalmic
6.3
6.8
17
28
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
40.7
6.8
8
*
C07AA05
ATC
propranolol; systemic
1.9
6.8
94
547
R4110
NOMESCO Finland
Physiotherapy
1.8
6.7
121
765
ZXA05
NOMESCO Finland
Left side
1.9
6.7
104
628
Z3226
NOMESCO Finland
Physiotherapist
2.0
6.7
82
457
T86
ICPC
Hypothyroidism/myxoedema
3.1
6.6
27
90
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
4.3
6.6
17
41
L04AX03
ATC
methotrexate; systemic
2.4
6.6
48
217
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
6.6
89
513
CB9S4
NOMESCO Finland
Photography of eyelids and eyebrows
70.9
6.4
7
*
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.8
6.3
31
115
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
+∞
6.3
6
*
CBB21
NOMESCO Finland
Correction of lax skin and resection of herniated fat in upper eyelid
+∞
6.3
6
*
CAB10
NOMESCO Finland
Lateral orbitotomy with excision of lesion
+∞
6.3
6
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
6.3
6
*
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
6.3
6
*
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
+∞
6.3
6
*
H05.9
ICD-10 Finland
Disorder of orbit, unspecified
+∞
6.3
6
*
E03
ICD-10 Finland
Other hypothyroidism
2.6
6.2
35
140
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
6.1
153
1058
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
8.8
6.1
12
14
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.6
6.0
34
136
A07AA02
ATC
nystatin; oral
2.9
6.0
28
101
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
104
90
15.15
105.79
3.0
1.7
2.74
3.93
iu/l
0.56
50
33
48
141
3.72
14.34
2.1
2.6
40.51
39.75
u/l
0.08
43
129
356
2793
3.12
14.32
8.1
4.3
15.36
14.85
pmol/l
3.25
334
2561
284
2047
2.27
12.97
13.3
9.6
4.33
4.08
e9/l
1.01
250
1787
254
1814
2.06
11.03
9.4
7.3
1.22
1.21
mmol/l
0.20
222
1567
230
1630
1.94
9.70
8.9
6.4
1.22
1.22
mmol/l
0.03
218
1503
222
1575
1.90
9.13
6.2
4.8
34.92
35.77
g/l
1.40
209
1485
97
524
2.12
8.76
1.9
2.0
28.35
29.27
s
1.15
90
511
72
346
2.31
8.66
3.5
2.0
320.70
391.30
nmol/l
2.58
66
326
269
2096
1.83
7.56
6.5
4.9
6.70
6.66
mmol/l
0.12
261
1982
98
562
1.98
7.41
2.5
2.0
—
—
—
0
0
98
583
1.90
6.58
3.8
3.5
0.80
0.81
mmol/l
0.37
92
548
371
3279
2.41
6.53
9.7
5.3
1.83
1.91
mu/l
0.45
351
3023
180
1287
1.71
6.48
4.1
3.6
2.37
2.36
mmol/l
0.76
164
1164
161
1122
1.72
6.33
2.6
2.1
180.07
185.89
u/l
0.07
153
1069
121
778
1.79
6.31
2.4
2.7
6.55
5.59
e6/l
0.25
109
724
129
853
1.75
6.07
2.6
2.3
—
—
—
0
0
145
991
1.72
6.07
3.9
3.2
0.60
0.39
e6/l
0.24
107
719
244
1919
1.67
5.94
4.3
3.8
0.00
0.00
estimate
0.50
53
399
208
1575
1.65
5.83
2.3
2.1
101.24
97.43
pmol/l
0.42
120
815
106
673
1.78
5.70
4.7
3.9
581.30
309.88
ng/l
0.35
86
516
315
2673
1.78
5.60
6.1
4.2
15.18
12.18
mm/h
2.31
301
2495
216
1663
1.63
5.58
17.8
12.7
1.24
1.22
inr
0.23
186
1373
243
1932
1.64
5.47
4.3
3.8
25.33
4.53
estimate
0.37
54
415
245
1952
1.64
5.47
4.3
3.8
0.15
0.02
estimate
0.65
47
388
215
1661
1.62
5.42
3.0
2.8
—
—
estimate
—
0
0
12
18
6.83
5.29
1.6
4.2
3818.50
786.33
u/ml
0.42
12
18
27
103
2.74
5.26
3.2
2.8
—
—
—
0
0
72
420
1.87
5.06
2.5
1.9
—
—
—
0
0
29
118
2.57
5.00
5.3
4.1
37.05
62.62
mg/l
0.51
24
101
29
118
2.57
5.00
5.3
4.1
35.29
48.34
mg/l
0.59
24
100
40
190
2.23
4.92
1.9
1.9
—
—
—
0
0
242
1955
1.58
4.83
7.8
6.4
10.88
11.03
umol/l
0.10
237
1867
33
148
2.34
4.64
1.8
2.2
1.63
1.45
g/l
0.37
26
135
48
253
2.02
4.53
1.5
1.2
223.31
152.55
u/ml
0.36
17
106
67
396
1.83
4.51
2.5
2.0
—
—
—
0
0
53
290
1.95
4.51
5.3
3.4
90.75
82.66
ng/l
0.28
48
253
92
599
1.69
4.43
3.7
2.9
0.99
1.02
e6/l
0.02
46
302
10
16
6.38
4.32
1.0
1.0
—
—
—
0
0
14
34
4.23
4.25
1.1
1.2
—
—
—
0
0
86
556
1.69
4.24
4.1
3.0
3.79
2.62
e6/l
0.29
40
260
66
402
1.77
4.02
9.3
9.4
1.56
0.94
mmol/l
0.71
54
339
45
243
1.96
3.98
1.8
2.9
202.62
186.43
ng/l
0.09
37
225
106
734
1.60
3.98
3.4
3.0
2.51
2.45
mmol/l
3.18
92
663
20
77
2.68
3.86
1.3
1.2
18.53
147.41
e6/l
0.87
15
58
42
224
1.98
3.85
2.7
2.4
27.98
17.89
au/ml
—
6
19
25
108
2.40
3.84
5.9
3.6
1.10
2.54
ratio
1.41
12
60
19
72
2.72
3.78
1.9
1.6
—
—
—
0
0
203
1636
1.48
3.71
2.7
2.5
77.45
78.25
nmol/l
0.15
189
1472
313
2759
1.57
3.67
11.8
7.9
80.62
79.59
u/l
0.17
301
2605
73
472
1.67
3.58
6.8
5.3
1.00
1.04
mmol/l
0.54
68
430
58
352
1.75
3.57
3.8
3.0
2.77
2.07
mmol/l
0.71
52
302
123
901
1.52
3.56
2.4
2.2
2.78
2.94
mg/l
0.33
113
780
17
63
2.77
3.53
1.9
1.2
—
—
—
0
0
17
63
2.77
3.53
1.9
1.2
—
—
—
0
0
6
6
10.12
3.50
1.8
1.8
—
—
—
0
0
22
94
2.42
3.47
1.2
1.2
—
—
—
0
0
19
76
2.57
3.43
1.2
1.2
20.29
8.57
e6/l
0.28
14
56
42
234
1.89
3.41
2.0
1.6
—
—
—
0
0
83
563
1.59
3.36
1.3
1.5
—
—
—
0
0
23
102
2.33
3.36
2.0
1.6
273.31
280.33
mu/l
0.06
23
96
375
3487
1.91
3.30
25.2
15.0
24.92
24.09
mg/l
0.18
334
2862
6
7
8.68
3.27
1.5
1.1
1.48
1.14
ratio
—
6
7
139
1069
1.45
3.10
1.7
1.7
21.12
20.48
nmol/l
0.20
119
893
54
337
1.69
3.02
2.6
2.6
33.89
34.51
u/l
0.04
46
282
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
94
2.30
3.02
2.5
2.2
0.37
0.39
iu/ml
0.09
12
54
21
94
2.30
3.02
1.8
1.5
—
—
—
0
0
123
931
1.46
2.96
2.9
2.6
341.46
339.02
umol/l
0.09
106
830
110
815
1.48
2.95
1.7
1.7
1.42
1.30
mg/l
0.13
87
648
204
1695
1.41
2.92
3.3
3.0
135.00
123.23
ug/l
0.29
194
1584
140
1090
1.43
2.89
3.0
3.2
1340.64
1282.39
ng/l
0.05
121
918
6
9
6.74
2.87
1.0
1.7
—
—
—
0
0
158
1259
1.42
2.87
4.7
3.2
7.02
7.48
mmol/l
0.53
130
1063
6
10
6.07
2.70
1.5
1.3
—
—
—
0
0
155
1241
1.40
2.70
3.1
3.1
31.34
30.40
u/l
0.09
145
1179
8
19
4.27
2.69
1.1
4.1
74.63
180.11
nmol/l
—
8
19
9
24
3.81
2.68
1.0
1.5
—
53.33
—
0
6
5
7
7.21
2.55
1.2
1.1
—
—
—
0
0
20
95
2.16
2.53
1.2
1.7
—
—
—
0
0
246
2141
1.37
2.51
3.2
3.0
—
—
—
0
0
19
89
2.19
2.49
1.1
1.6
—
—
—
0
0
8
21
3.86
2.47
1.1
1.7
—
—
—
0
0
170
1399
1.37
2.46
3.7
3.6
37.06
80.85
ng/l
0.55
115
1006
151
1222
1.37
2.42
4.5
4.0
15.86
8.04
mg/mmol
0.69
92
755
82
597
1.47
2.38
2.0
1.7
1013.13
1250.70
nmol/l
1.48
58
452
21
106
2.03
2.30
1.3
1.3
—
—
—
0
0
27
150
1.86
2.26
2.1
2.0
6.06
9.30
iu/ml
—
5
43
5
9
5.61
2.22
1.2
2.6
—
—
—
0
0
18
87
2.12
2.20
1.2
1.6
—
—
—
0
0
87
653
1.42
2.15
1.4
1.3
23.51
13.20
u/ml
0.37
30
263
58
403
1.51
2.12
1.8
2.5
5.81
7.41
umol/l
0.70
51
356
69
497
1.47
2.11
9.2
7.1
103.55
104.11
mmol/l
0.42
69
497
44
287
1.60
2.11
1.6
1.4
—
—
—
0
0
18
89
2.07
2.09
2.1
2.9
0.63
1.60
index
—
8
47
6
15
4.04
2.04
1.0
1.0
—
—
—
0
0
6
15
4.04
2.04
1.0
1.1
—
—
—
0
0
14
63
2.27
2.03
1.9
3.2
—
1086.43
—
0
7
93
716
1.39
1.98
1.6
1.3
17.27
33.90
iu/ml
2.17
22
232
9
33
2.77
1.94
1.1
1.2
—
—
—
0
0
9
33
2.77
1.94
1.1
1.2
—
—
—
0
0
7
22
3.22
1.88
1.7
3.5
1052.29
1033.77
mg
—
7
22
8
28
2.89
1.87
1.0
1.1
—
—
—
0
0
267
2418
1.30
1.75
3.9
3.2
45.77
48.78
u/l
0.35
251
2287
9
36
2.53
1.75
4.1
4.9
—
—
—
0
0
19
103
1.89
1.74
1.3
1.2
—
—
—
0
0
52
369
1.47
1.73
2.9
3.4
—
—
—
0
0
5
13
3.88
1.72
1.0
1.4
237.40
69.92
nmol/24h
—
5
13
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
13
3.88
1.72
1.0
1.2
—
—
—
0
0
5
13
3.88
1.72
1.0
2.8
41.04
42.60
g/l
—
5
13
12
55
2.22
1.69
1.1
1.7
—
—
—
0
0
22
127
1.77
1.67
2.1
2.0
—
—
—
0
0
7
25
2.83
1.65
1.0
1.2
—
—
—
0
0
30
190
1.62
1.65
3.5
3.4
1.37
1.87
mmol/l
0.32
22
144
13
64
2.07
1.55
1.1
1.7
—
—
—
0
0
360
3425
1.43
1.54
5.9
5.1
6.12
5.95
mmol/l
0.96
333
3160
20
116
1.76
1.51
2.1
1.9
—
—
—
0
0
9
37
2.46
1.48
1.0
1.2
—
—
—
0
0
16
87
1.87
1.48
1.6
1.3
—
—
—
0
0
20
117
1.75
1.48
1.2
1.3
—
—
—
0
0
15
80
1.91
1.46
1.2
1.6
—
—
—
0
0
6
22
2.75
1.44
1.2
1.0
—
—
—
0
0
354
3372
1.37
1.37
7.9
6.3
40.45
39.21
mmol/mol
1.74
331
3172
13
68
1.94
1.35
1.2
1.6
—
—
—
0
0
10
48
2.11
1.28
1.2
1.5
—
—
—
0
0
8
35
2.31
1.27
3.0
2.5
—
—
—
0
0
16
92
1.77
1.27
1.2
1.2
—
55.07
—
0
13
25
163
1.57
1.26
1.1
1.0
—
—
—
0
0
24
155
1.58
1.26
1.8
1.8
0.65
1.28
ug/l
0.78
19
140
103
859
1.27
1.24
1.5
1.3
1.64
1.99
u/ml
0.17
29
249
5
19
2.65
1.22
1.0
1.6
—
—
—
0
0
8
38
2.13
1.19
2.0
3.2
2.18
3.70
nmol/l
—
8
38
17
102
1.70
1.18
1.3
1.3
123.50
230.86
miu/ml
—
10
47
5
20
2.52
1.15
1.0
1.8
—
—
—
0
0
5
20
2.52
1.15
1.0
1.8
—
—
—
0
0
5
20
2.52
1.15
1.0
1.6
—
—
—
0
0
33
234
1.45
1.15
2.8
2.9
131.24
130.35
g/l
0.09
33
227
12
65
1.87
1.14
1.1
1.6
—
—
—
0
0
7
30
2.36
1.13
1.7
1.2
213.71
310.92
mu/l
—
7
25
8
40
2.02
1.12
1.0
1.7
—
—
—
0
0
16
96
1.69
1.12
1.2
1.2
—
—
—
0
0
167
1484
1.21
1.11
4.1
3.7
0.00
0.03
estimate
1.47
41
342
19
120
1.61
1.10
2.8
2.5
25.16
25.13
mmol/l
0.01
19
120
15
89
1.71
1.09
2.3
2.3
8.39
7.90
kpa
0.83
15
89
18
114
1.61
1.04
1.2
1.3
282.00
315.37
ug/g
—
10
61
10
53
1.91
1.02
1.1
1.6
—
—
—
0
0
7
35
2.02
1.00
1.0
1.8
—
—
—
0
0
49
384
1.31
0.97
4.8
4.4
246.61
35.52
ug/l
0.42
38
323
6
120
0.49
0.95
2.3
1.6
—
—
—
0
0
6
27
2.24
0.94
1.2
1.2
—
—
—
0
0
13
78
1.69
0.92
1.8
2.9
6.84
8.37
pmol/l
0.45
13
78
6
28
2.16
0.92
1.2
1.2
—
—
—
0
0
6
29
2.08
0.89
1.2
1.2
—
—
—
0
0
6
29
2.08
0.89
1.2
1.2
—
—
—
0
0
387
3783
1.43
0.85
37.2
23.3
256.62
252.38
e9/l
0.51
377
3715
15
96
1.58
0.85
1.1
1.1
—
5.12
—
0
13
6
31
1.95
0.84
1.2
1.2
—
—
—
0
0
6
31
1.95
0.84
1.2
1.5
—
—
—
0
0
387
3785
1.42
0.83
37.0
23.2
4.41
4.48
e12/l
1.63
376
3706
387
3785
1.42
0.83
38.0
23.7
39.84
40.32
%
1.07
382
3749
351
3392
1.25
0.81
24.1
14.8
81.68
80.75
ml/min/173m2
0.37
335
3143
8
48
1.68
0.79
1.0
1.0
—
—
—
0
0
96
835
1.20
0.78
4.3
3.8
1.02
1.02
kg/l
1.09
62
555
6
34
1.78
0.76
1.0
1.1
—
—
—
0
0
6
34
1.78
0.76
1.2
1.2
—
—
—
0
0
10
59
1.71
0.76
1.1
1.5
—
—
—
0
0
379
3701
1.33
0.76
17.3
11.7
26.76
25.78
u/l
0.53
374
3598
5
24
2.10
0.74
1.0
1.6
—
—
—
0
0
14
92
1.54
0.73
1.5
1.3
—
—
—
0
0
122
1091
1.17
0.72
4.6
3.8
0.00
0.01
estimate
0.74
49
387
21
152
1.40
0.70
2.0
1.9
—
—
—
0
0
119
1065
1.17
0.70
3.5
3.3
0.02
0.01
estimate
0.26
41
332
366
3565
1.25
0.69
6.5
5.8
2.69
2.75
mmol/l
0.56
344
3320
7
118
0.59
0.69
1.3
1.6
—
—
—
0
0
25
189
1.34
0.66
1.3
1.4
—
—
—
0
0
7
44
1.60
0.65
1.3
1.1
119.43
111.44
%
—
7
39
170
1573
1.14
0.62
1.9
1.9
1.45
1.37
mmol/l
0.80
143
1324
22
165
1.35
0.62
1.7
1.3
30.92
26.10
iu/l
0.27
17
141
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
13
89
1.48
0.58
1.8
2.1
698.00
48.86
ug/min
—
6
51
22
285
0.76
0.58
2.2
1.9
3.22
3.49
mmol/l
0.48
15
220
19
142
1.35
0.55
2.0
3.3
36.86
1640.03
u/ml
0.93
14
120
68
594
1.17
0.55
1.4
1.6
—
—
—
0
0
359
3509
1.19
0.52
5.6
5.2
4.65
4.70
mmol/l
0.48
341
3280
17
127
1.35
0.50
1.8
1.9
—
—
—
0
0
37
309
1.22
0.49
1.8
1.8
—
—
—
0
0
7
47
1.50
0.48
1.1
1.1
—
—
—
0
0
357
3494
1.17
0.46
5.6
5.1
1.42
1.49
mmol/l
2.43
329
3253
7
49
1.44
0.46
1.4
1.3
6.71
7.33
mmol/l
—
7
39
99
905
1.12
0.43
5.2
4.9
2.33
2.25
ug/l
0.03
94
812
33
277
1.21
0.42
1.6
1.7
—
—
—
0
0
28
231
1.23
0.42
3.8
2.7
82.94
111.29
u/ml
0.18
28
225
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
342
3345
1.14
0.40
4.9
4.3
1.49
1.30
mmol/l
3.33
311
3090
34
288
1.20
0.40
2.6
2.7
59.93
65.79
ml/min/173m2
0.41
15
112
5
34
1.48
0.40
1.2
1.1
93.40
93.83
%
—
5
29
35
299
1.19
0.38
4.0
3.7
1.24
1.23
mmol/l
0.28
29
252
5
37
1.36
0.37
1.6
1.5
—
—
—
0
0
33
384
0.85
0.37
2.3
2.1
3.42
3.50
ratio
0.13
27
316
20
162
1.25
0.36
1.8
1.4
—
—
—
0
0
6
44
1.37
0.34
1.2
1.3
—
—
—
0
0
6
44
1.37
0.34
1.2
1.4
—
—
—
0
0
6
44
1.37
0.34
1.2
1.4
—
—
—
0
0
12
92
1.31
0.32
1.2
1.2
—
—
—
0
0
12
92
1.31
0.32
1.2
1.2
—
—
—
0
0
34
296
1.16
0.31
1.9
2.3
6.60
6.30
ug/l
0.07
27
272
7
53
1.33
0.31
1.3
1.0
—
1.49
—
0
10
7
55
1.28
0.30
2.0
2.0
10.00
10.55
mmol/l
—
7
55
35
307
1.15
0.30
2.3
2.3
0.78
0.43
e6/l
0.30
35
289
82
761
1.10
0.29
1.9
1.7
421.70
29734402.60
pmol/l
0.77
70
639
15
123
1.23
0.25
1.7
1.4
—
—
—
0
0
77
718
1.09
0.25
4.4
4.1
21.16
22.23
%
0.22
35
344
5
39
1.29
0.23
1.6
1.3
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
5
41
1.22
0.22
1.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
6
50
1.20
0.20
1.2
1.6
—
—
—
0
0
11
91
1.21
0.17
1.0
1.1
—
13.67
—
0
6
44
409
1.08
0.16
8.5
7.5
—
—
—
0
0
13
111
1.18
0.16
1.5
1.4
—
—
—
0
0
9
78
1.16
0.15
1.7
1.3
—
—
—
0
0
5
44
1.14
0.10
1.6
2.0
—
—
—
0
0
5
45
1.11
0.10
4.0
3.5
19.80
38.13
u/ml
—
5
45
18
166
1.09
0.08
2.8
1.6
0.24
0.38
mg/l
—
9
72
9
86
1.05
0.07
5.7
4.1
55.89
28.08
u/ml
—
9
86
19
177
1.08
0.06
3.0
3.1
25.19
25.00
mmol/l
0.07
19
172
52
536
0.97
0.05
3.6
2.9
0.56
0.78
ug/l
2.74
34
336
43
441
0.97
0.03
5.6
4.9
33.69
32.63
%
0.29
36
285
13
132
0.98
0.00
1.2
1.2
1.00
0.89
g/l
0.41
13
132
13
129
1.01
0.00
1.2
1.1
1.53
1.55
g/l
0.14
13
129
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
30.20
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
1.27
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
42.63
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
106.83
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
96.40
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint H7_EXOPTHALMUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EXOPTHALMUS | 1.549 [1.32, 1.81] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.273 |
During the follow-up period (1.1.1998 — 31.12.2019), 278 out of 1435 females with H7_EXOPTHALMUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EXOPTHALMUS | 1.813 [1.45, 2.26] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 830 males with H7_EXOPTHALMUS died.
Mortality risk
Mortality risk for people of age
years, who have H7_EXOPTHALMUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.196% | 0.362% |
| 5 | 1.061% | 2.038% |
| 10 | 2.346% | 4.945% |
| 15 | 4.535% | 8.688% |
| 20 | 7.683% | 14.48% |
Relationships between endpoints
↥Index endpoint: H7_EXOPTHALMUS – Exophthalmic conditions
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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