lens disease: A disease involving the lens of camera-type eye. [database_cross_reference: MONDO:DesignPattern]
Other specified and unspecified disorders of lens
DOID EFO Endpoint Browser PheWeb
H7_DISORDERLENSNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
363 |
4. Check minimum number of eventsNone |
363 |
5. Include endpointsNone |
363 |
6. Filter based on genotype QC (FinnGen only) |
325 |
Control definitions (FinnGen only)
- Control exclude
- H7_LENS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified and unspecified disorders of lens
based on the number of shared cases.
Similar with more cases:
- Disorders of lens
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2266 | 1677 | 581 |
| Only index persons | 2126 | 1584 | 542 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 76.62 | 76.97 | 75.56 |
| Only index persons | 76.59 | 76.93 | 75.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 325 | 225 | 100 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.05 |
| Median age at first event (years) | 74.20 | 73.80 | 75.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 335
- Matched controls
- 3350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
334.1
307.7
261
35
H27.8
ICD-10 Finland
Other specified disorders of lens
4503599627370496.0
307.7
323
*
H25.1
ICD-10 Finland
Senile nuclear cataract
63.2
303.6
190
68
Z96.1
ICD-10 Finland
Presence of intraocular lens
29.8
198.4
155
94
WX100
NOMESCO Finland
Conjunctival surface anesthesia
65.9
194.8
111
25
H25.8
ICD-10 Finland
Other senile cataract
253.2
140.9
136
9
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
33.6
110.7
74
28
H40.0
ICD-10 Finland
Glaucoma suspect
10.5
80.5
107
143
H26.4
ICD-10 Finland
After-cataract
149.5
77.9
80
7
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
7.1
71.4
206
618
S01ED51
ATC
timolol, combinations; ophthalmic
10.3
69.5
90
115
CJB10
NOMESCO Finland
Laser discission of secondary cataract
104.4
62.6
67
8
H25.0
ICD-10 Finland
Senile incipient cataract
17.8
53.0
45
29
114
Kela drug reimbursment
Glaucoma
6.4
43.4
86
172
WX140
NOMESCO Finland
Parabulbar anesthesy
10.8
37.6
43
45
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.5
35.3
49
66
S01EE01
ATC
latanoprost; ophthalmic
6.3
31.7
60
113
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
12.6
29.5
30
26
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
4.2
25.0
81
238
S01EC04
ATC
brinzolamide; ophthalmic
7.3
23.4
36
54
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.1
22.2
210
1177
H04.10
ICD-10 Finland
Dry eye syndrome
4.3
21.5
63
171
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
6.7
21.1
35
57
CHD00
NOMESCO Finland
Laser trabeculoplasty
24.3
20.8
29
13
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
5.3
19.8
43
91
CS494
NOMESCO Finland
Other visual field testing
16.1
19.3
31
21
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.8
18.7
45
104
SPAT1263
SPAT
Sampling
2.6
17.1
176
988
WX110
NOMESCO Finland
Infiltration anesthesia
2.8
16.8
236
1538
CKD60
NOMESCO Finland
Anterior vitrectomy
94.9
16.7
18
*
S01ED01
ATC
timolol; ophthalmic
6.4
16.3
28
47
XCH00
NOMESCO Finland
Eye pressure measurement
6.6
16.2
27
44
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.2
16.1
47
126
S01EE05
ATC
tafluprost; ophthalmic
5.8
15.7
30
56
S01EA05
ATC
brimonidine; ophthalmic
13.2
15.7
27
22
XCK00
NOMESCO Finland
Perimetry
4.7
15.2
37
86
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
14.3
208
1334
SPAT1312
SPAT
General health counselling
2.5
14.1
128
662
WW200, ,
SPAT
2.5
14.1
126
648
AA1AD
NOMESCO Finland
CT of head and brain
2.4
13.9
149
831
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
4.6
13.7
34
80
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.4
12.8
143
805
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
12.8
121
633
H27.1
ICD-10 Finland
Dislocation of lens
+∞
12.6
12
*
CHC05
NOMESCO Finland
Iridotomy
16.7
12.3
19
12
Z97.2
ICD-10 Finland
Presence of dental prosthetic device (complete)(partial)
5.2
11.9
25
51
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
3.7
11.8
40
119
SPAT1310
SPAT
Counselling related to known health issue
2.3
11.8
128
707
H53.1
ICD-10 Finland
Subjective visual disturbances
4.0
11.6
35
96
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.2
11.4
166
1031
DAX08
NOMESCO Finland
Fitting of hearing aid
3.5
11.1
41
129
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
10.9
68
289
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
29.1
10.8
14
5
WX720
NOMESCO Finland
Own respiration
4.6
10.7
26
60
A98
ICPC
Health maint/preventive medicine
3.9
10.7
311
2574
S01EC01
ATC
acetazolamide; systemic
12.6
10.5
18
15
SAA03
NOMESCO Finland
Extended examination of mouth
2.2
10.4
116
641
SPAT1360
SPAT
Extensive global examination
3.4
10.4
39
124
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
24.3
10.3
14
6
SPAT1211
SPAT
Application of soft bandage
3.1
10.1
46
165
SPAT1153
SPAT
Removal of sutures
2.1
9.9
127
741
N06AX26
ATC
vortioxetine; oral
4.5
9.8
24
56
NG2AA
NOMESCO Finland
Patella X-ray examination
4.8
9.7
22
48
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
9.6
105
574
SPAT1325
SPAT
Vaccination
2.1
9.6
150
941
H27.9
ICD-10 Finland
Disorder of lens, unspecified
+∞
9.4
9
*
H52.2
ICD-10 Finland
Astigmatism
11.1
9.4
17
16
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.4
9.3
75
360
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.5
9.2
66
300
Z75.1
ICD-10 Finland
Person awaiting admission to adequate facility elsewhere
7.4
9.2
21
30
S01EC54
ATC
brinzolamide, combinations; ophthalmic
16.2
9.1
14
9
CHD35
NOMESCO Finland
Laser goniopuncture
37.8
9.1
11
*
E0000UV, ,
ATC
2.0
9.0
149
947
SPAT1053
SPAT
Memory test
2.2
9.0
92
487
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
2.1
9.0
108
611
-45
ICPC
Observ/health educat/advice/diet
5.1
8.9
19
39
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
8.8
160
1051
S01EC03
ATC
dorzolamide; ophthalmic
14.5
8.8
14
10
DFF00
NOMESCO Finland
Pure tone audiometry
2.5
8.6
58
256
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
8.2
8.5
18
23
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.6
8.5
53
225
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
8.4
171
1161
SPAT1172
SPAT
Guidance concerning hydration
4.3
8.4
22
54
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
8.3
71
348
WZA90
NOMESCO Finland
Other medical or dental certificate
2.2
8.2
78
400
UKC02
NOMESCO Finland
Cystoscopy
2.3
8.2
71
350
XCW10
NOMESCO Finland
Assessment of vision
12.1
8.1
14
12
NF1AA
NOMESCO Finland
Hip X-ray examination
2.5
8.1
58
262
H52.1
ICD-10 Finland
Myopia
10.4
8.1
15
15
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
4.5
8.1
20
47
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
4.8
8.0
18
39
L15
ICPC
Knee symptom/complaint
2.1
7.9
98
557
WX002
NOMESCO Finland
Sedation and analgesia
2.2
7.9
74
377
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.8
7.9
41
158
K03.66
ICD-10 Finland
Tooth plaque
3.4
7.7
29
92
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.8
7.7
40
154
JN3AD
NOMESCO Finland
Abdominal CT examination
2.5
7.6
54
243
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
25.7
7.6
10
*
SAA01
NOMESCO Finland
Simple examination of mouth
1.9
7.6
200
1464
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
4.2
7.5
20
50
WX320
NOMESCO Finland
Spinalanesthesy
2.0
7.4
103
608
H52.0
ICD-10 Finland
Hypermetropia
8.7
7.4
15
18
D06BB10
ATC
imiquimod; topical
3.2
7.4
29
95
SPAT1254
SPAT
Administration of medicine
2.2
7.4
74
387
F16
ICPC
Eyelid symptom/complaint
3.6
7.3
24
70
S01EA03
ATC
apraclonidine; ophthalmic
30.7
7.2
9
*
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
3.3
7.2
27
86
WX725
NOMESCO Finland
Noninvasive ventilation
3.5
7.1
25
76
P20
ICPC
Memory disturbance
2.0
7.0
93
538
CBB30
NOMESCO Finland
Excision of lesion of eyelid
4.5
7.0
17
39
SPAT1097
SPAT
Recording of ECG
2.2
7.0
68
350
M01AX05
ATC
glucosamine; oral
2.0
7.0
104
627
K03.64
ICD-10 Finland
Dental calculus supragingival
2.0
7.0
88
501
S18
ICPC
Laceration/cut
1.8
6.9
165
1157
D07AB02
ATC
hydrocortisone butyrate; topical
2.0
6.9
100
597
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
3.0
6.9
31
110
R02
ICPC
Shortness of breath/dyspnoea
2.2
6.9
61
303
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.7
6.8
22
63
S01EE04
ATC
travoprost; ophthalmic
5.7
6.7
18
33
L90
ICPC
Osteoarthrosis of knee
2.7
6.5
37
149
SAA02
NOMESCO Finland
Basic examination of mouth
1.8
6.5
178
1294
L57.0
ICD-10 Finland
Actinic keratosis
2.1
6.5
66
346
F29
ICPC
Eye symptom/complaint other
2.5
6.4
41
175
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.7
6.4
20
56
H40.9
ICD-10 Finland
Glaucoma, unspecified
6.8
6.4
15
23
XF640, ,
NOMESCO Finland
4.0
6.3
18
47
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
6.3
78
439
H26.9
ICD-10 Finland
Cataract, unspecified
18.4
6.3
9
5
C10AA07
ATC
rosuvastatin; oral
1.9
6.3
113
721
WX144
NOMESCO Finland
Subconjunctival anesthesy
+∞
6.3
6
*
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
+∞
6.3
6
*
CJF15
NOMESCO Finland
Secondary implantation of skleral fixed artificial lens in posterior chamber
+∞
6.3
6
*
G04BD12
ATC
mirabegron; oral
2.1
6.2
64
336
R53
ICD-10 Finland
Malaise and fatigue
1.9
6.2
103
640
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.2
117
758
L12
ICPC
Hand/finger symptom/complaint
2.2
6.2
59
301
SPAT1301
SPAT
No procedures
1.8
6.1
123
811
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
6.1
122
803
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.6
6.1
36
148
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
3.5
6.1
21
63
H81
ICPC
Excessive ear wax
2.0
6.1
77
437
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
6.0
41
181
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
138
300
7.12
66.30
5.8
5.2
36.53
35.28
%
0.42
68
166
151
644
3.45
26.93
1.8
1.8
857.05
1183.40
nmol/l
5.78
101
482
249
1462
3.74
25.90
3.0
2.3
110.16
94.70
pmol/l
2.81
125
706
237
1467
3.10
20.17
6.6
6.1
1.22
1.22
mmol/l
0.42
196
1344
229
1402
3.00
19.67
4.0
3.0
47.81
52.45
u/l
0.32
199
1278
249
1644
3.00
17.71
8.3
6.7
1.23
1.22
mmol/l
0.55
201
1421
49
129
4.28
17.24
2.3
2.1
—
—
—
0
0
47
121
4.35
17.02
2.3
1.9
—
—
—
0
0
313
2400
5.63
16.96
7.2
6.1
2.37
2.54
mmol/l
2.80
256
2165
312
2390
5.45
16.85
7.4
5.7
6.00
6.06
mmol/l
0.35
256
2141
305
2317
4.53
16.22
7.2
5.8
2.08
2.05
mu/l
0.10
255
2098
305
2324
4.49
15.99
6.2
5.2
4.43
4.49
mmol/l
0.48
251
2104
305
2343
4.37
15.35
8.8
7.1
40.50
40.20
mmol/mol
0.20
252
2142
321
2563
7.04
15.27
16.0
12.5
21.99
22.72
u/l
0.56
299
2466
82
329
2.98
15.03
5.0
7.5
—
—
—
0
0
302
2318
4.07
14.92
6.6
5.1
1.61
1.52
mmol/l
2.74
244
2091
294
2225
3.63
14.72
5.0
4.3
1.15
1.24
mmol/l
2.03
229
1973
270
1956
2.96
14.44
5.7
4.3
15.15
16.14
mm/h
0.43
231
1795
282
2103
3.16
14.06
9.6
8.1
79.84
81.52
u/l
0.23
257
1973
163
948
2.40
13.80
2.2
2.0
116.62
304.76
u/l
1.65
152
887
150
847
2.40
13.50
2.5
2.3
2.98
3.04
mg/l
0.09
117
711
186
1154
2.38
13.48
5.3
4.3
32.98
120.24
ng/l
0.91
156
909
320
2611
6.04
13.31
31.4
23.8
139.20
139.45
mmol/l
0.78
312
2559
320
2611
6.04
13.31
31.6
24.0
3.99
4.00
mmol/l
0.15
312
2554
321
2633
6.24
13.08
34.4
26.1
81.31
80.87
umol/l
0.09
316
2593
149
851
2.35
12.94
2.8
2.3
55.72
60.36
u/l
0.48
133
782
225
1533
2.42
12.93
7.0
6.2
12.57
12.04
umol/l
0.14
210
1462
321
2645
6.11
12.72
38.2
28.9
4.24
4.30
e12/l
1.41
314
2562
321
2645
6.11
12.72
38.2
28.9
246.28
246.52
e9/l
0.02
316
2572
240
1695
2.47
12.53
6.4
5.0
6.88
6.78
mmol/l
0.36
233
1603
217
1474
2.34
12.28
20.2
17.7
1.31
1.35
inr
0.40
186
1218
164
994
2.27
12.18
2.2
1.7
20.64
20.81
nmol/l
0.04
117
824
196
1285
2.27
11.95
2.9
2.4
82.14
81.23
nmol/l
0.15
152
1116
308
2498
3.89
11.74
24.6
19.3
23.07
29.22
mg/l
2.56
277
2139
22
43
5.41
10.94
2.8
2.3
17.75
34.12
mg/l
—
8
17
259
1950
2.45
10.82
5.0
4.6
15.32
15.39
pmol/l
0.17
204
1757
47
165
3.15
10.68
2.1
4.2
1.94
2.26
mmol/l
0.19
39
124
174
1134
2.11
10.20
3.0
2.3
—
—
—
0
0
112
617
2.22
10.11
2.8
1.8
—
—
—
0
0
174
1147
2.08
9.76
3.3
2.9
122.07
138.37
ug/l
0.59
148
1031
126
738
2.13
9.67
2.7
2.4
—
—
—
0
0
30
84
3.82
9.62
1.7
1.4
—
—
—
0
0
152
975
2.02
8.97
3.5
3.2
6.13
6.39
mmol/l
0.38
103
814
47
182
2.84
8.96
1.5
1.4
—
—
—
0
0
155
1004
2.01
8.88
4.2
3.9
3.63
10.52
mg/mmol
2.90
72
595
168
1122
2.00
8.80
3.9
3.3
2061.76
1950.92
ng/l
0.08
129
993
30
93
3.44
8.29
3.4
2.8
—
—
—
0
0
287
2364
2.49
8.19
22.0
20.2
66.58
70.08
ml/min/173m2
2.16
261
2223
180
1295
1.84
6.96
3.3
2.7
—
—
estimate
—
0
0
140
933
1.86
6.92
2.0
1.9
1.06
1.25
mmol/l
2.97
99
771
107
654
1.93
6.90
1.5
1.8
524.24
439.38
pmol/l
1.71
78
520
53
256
2.27
6.35
1.7
1.6
—
—
—
0
0
16
30
5.55
5.92
1.9
2.3
—
—
—
0
0
16
41
4.05
5.78
1.6
1.5
—
—
—
0
0
70
392
1.99
5.71
4.6
4.2
248.02
264.52
u/l
0.36
61
373
16
42
3.95
5.60
1.6
1.5
—
—
—
0
0
16
42
3.95
5.60
1.6
1.5
—
—
—
0
0
201
1561
1.72
5.43
9.2
9.1
4.24
4.24
e9/l
0.00
167
1322
20
64
3.26
5.28
1.6
1.7
—
—
—
0
0
15
40
3.88
5.15
1.6
1.5
—
—
—
0
0
15
40
3.88
5.15
1.6
1.5
—
—
—
0
0
15
40
3.88
5.15
1.6
1.5
—
—
—
0
0
91
576
1.80
5.06
1.6
1.6
1.06
1.67
mg/l
1.91
74
467
100
653
1.76
4.99
3.3
3.0
336.31
352.95
umol/l
0.76
75
560
20
67
3.11
4.91
1.5
1.4
—
—
—
0
0
50
262
2.07
4.87
2.0
1.7
—
—
—
0
0
12
23
5.37
4.50
1.3
1.7
—
—
—
0
0
12
23
5.37
4.50
1.2
1.7
—
—
—
0
0
74
463
1.77
4.21
2.6
1.7
—
—
—
0
0
14
42
3.44
4.09
1.1
1.9
—
—
—
0
0
182
1442
1.57
4.03
5.3
4.4
33.97
34.35
g/l
0.36
161
1342
18
65
2.87
3.92
1.7
1.7
—
—
—
0
0
29
134
2.27
3.86
1.9
2.1
5.12
1.94
ug/l
0.46
24
112
8
12
6.80
3.69
1.1
1.0
—
—
—
0
0
51
299
1.83
3.58
2.5
3.2
116.95
85.22
ng/l
0.51
39
250
86
588
1.62
3.48
8.5
6.1
8.29
2.83
ug/l
0.77
77
504
62
931
0.59
3.48
5.4
3.5
0.46
0.54
e6/l
0.13
49
675
66
424
1.69
3.39
4.0
4.7
1.01
1.06
mmol/l
0.96
58
379
9
19
4.84
3.26
1.1
1.2
—
—
—
0
0
25
117
2.23
3.25
1.8
2.0
199.71
842.86
ug/l
1.01
25
112
7
11
6.47
3.20
1.0
1.9
—
—
—
0
0
7
11
6.47
3.20
1.0
1.9
—
—
—
0
0
7
11
6.47
3.20
1.0
1.9
—
—
—
0
0
7
11
6.47
3.20
1.0
1.9
—
—
—
0
0
6
8
7.61
3.06
1.0
1.9
—
—
—
0
0
6
8
7.61
3.06
1.0
1.9
—
—
—
0
0
109
814
1.50
2.94
3.8
2.7
26.09
33.39
u/l
3.61
98
768
6
9
6.76
2.88
1.0
1.8
—
—
—
0
0
24
119
2.10
2.74
1.3
1.2
—
—
—
0
0
10
29
3.52
2.71
1.2
1.2
—
—
—
0
0
10
29
3.52
2.71
1.2
1.2
—
—
—
0
0
91
668
1.50
2.64
7.3
4.1
571.16
283.68
ng/l
0.23
76
596
5
7
7.23
2.55
1.0
1.6
44.86
40.79
g/l
—
5
7
17
75
2.33
2.55
1.2
1.3
—
—
—
0
0
175
1464
1.41
2.48
5.1
4.6
0.00
14.53
estimate
1.04
24
359
6
12
5.07
2.41
3.7
1.3
—
—
—
0
0
6
12
5.07
2.41
1.0
1.2
—
—
—
0
0
5
8
6.32
2.38
2.2
2.8
18.78
16.88
nmol/l
—
5
8
8
22
3.70
2.38
1.1
1.8
—
—
—
0
0
8
22
3.70
2.38
1.1
1.8
—
—
—
0
0
8
22
3.70
2.38
1.1
1.8
—
—
—
0
0
21
106
2.05
2.31
1.0
1.0
—
—
—
0
0
10
34
3.00
2.30
1.4
1.8
—
—
—
0
0
67
475
1.51
2.27
6.6
5.0
22.85
21.38
%
0.34
38
260
47
307
1.62
2.27
1.7
1.3
—
—
—
0
0
8
24
3.39
2.19
1.1
1.3
—
—
—
0
0
11
42
2.67
2.16
1.4
1.7
—
—
—
0
0
11
42
2.67
2.16
1.7
1.8
—
—
—
0
0
6
14
4.34
2.16
1.0
1.0
—
—
—
0
0
6
14
4.34
2.16
1.0
1.0
—
—
—
0
0
10
36
2.83
2.15
1.7
1.8
—
—
—
0
0
7
20
3.55
2.06
1.3
1.3
—
—
—
0
0
7
20
3.55
2.06
1.3
1.3
—
—
—
0
0
12
50
2.45
2.05
1.7
1.7
—
—
—
0
0
7
21
3.38
1.97
1.3
1.0
—
—
—
0
0
11
45
2.49
1.95
1.2
1.4
—
—
—
0
0
7
22
3.23
1.89
1.6
1.1
—
—
—
0
0
75
568
1.41
1.81
2.9
2.5
11.17
11.38
umol/l
0.09
64
520
30
186
1.67
1.79
2.4
1.7
1.59
1.70
g/l
0.26
24
167
172
1487
1.32
1.76
5.4
4.5
0.00
0.88
estimate
0.50
22
339
6
18
3.37
1.75
1.0
1.0
—
—
—
0
0
78
600
1.39
1.72
5.7
4.8
1.01
1.02
kg/l
2.52
64
382
5
13
3.89
1.72
1.2
1.2
—
—
—
0
0
66
495
1.42
1.68
2.8
2.5
18.74
20.20
%
0.44
56
459
21
120
1.80
1.66
2.0
3.8
1.71
7.23
ratio
0.88
15
60
70
532
1.40
1.66
3.0
2.5
2.36
2.26
g/l
0.70
57
484
70
533
1.40
1.64
3.2
2.8
0.81
0.81
mmol/l
0.12
54
488
58
767
0.71
1.63
2.7
3.0
2.49
2.49
mmol/l
0.02
48
687
7
26
2.73
1.59
1.0
2.0
—
—
—
0
0
27
170
1.64
1.54
1.5
2.6
6.82
7.69
g/l
2.25
19
155
27
170
1.64
1.54
1.5
2.6
4.33
4.20
g/l
0.36
19
155
27
170
1.64
1.54
1.5
2.5
3.43
3.61
g/l
0.28
19
155
5
15
3.37
1.53
1.0
1.0
1.34
1.43
g/l
—
5
15
9
37
2.47
1.49
1.4
1.4
—
—
—
0
0
52
384
1.42
1.45
6.3
6.8
0.91
0.98
mmol/l
0.05
44
317
25
157
1.64
1.45
1.5
2.7
2.52
3.18
g/l
2.97
17
142
5
16
3.16
1.44
3.0
1.7
170.00
105.81
nmol/l
—
5
16
7
29
2.44
1.40
1.3
1.3
—
271.78
miu/ml
—
0
8
24
151
1.63
1.39
1.6
2.6
0.00
0.98
g/l
2.89
15
130
165
1455
1.26
1.33
5.2
4.5
0.00
0.00
estimate
-0.00
24
344
38
270
1.46
1.31
1.2
1.4
—
—
—
0
0
16
265
0.58
1.29
5.8
3.9
1.23
1.23
mmol/l
0.09
16
225
52
394
1.38
1.27
1.1
1.3
29.93
42.29
iu/ml
0.43
19
130
95
1129
0.78
1.26
4.7
3.5
—
—
—
0
0
45
588
0.73
1.17
3.8
3.2
0.73
1.50
e6/l
1.90
22
302
7
30
2.36
1.13
2.3
1.4
—
—
—
0
0
7
31
2.28
1.11
1.3
1.7
—
—
—
0
0
132
1156
1.23
1.08
2.6
3.4
2.35
2.37
mmol/l
0.95
99
1033
6
27
2.24
0.94
1.0
1.1
—
—
—
0
0
13
79
1.67
0.89
1.2
1.5
306.00
246.31
ug/g
—
8
50
6
30
2.02
0.87
1.0
1.1
—
—
—
0
0
44
550
0.77
0.86
3.8
3.2
2.08
3.84
e6/l
1.06
20
263
6
31
1.95
0.85
1.5
2.1
—
—
—
0
0
48
385
1.29
0.83
1.2
1.3
50.94
20.71
u/ml
—
7
101
34
260
1.34
0.82
2.2
2.3
16.35
7.53
ug/l
0.41
17
217
87
750
1.22
0.81
4.8
3.9
0.00
0.15
estimate
0.82
15
263
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
106
1.53
0.80
1.7
2.0
0.34
0.36
iu/ml
—
8
61
0
26
0.00
0.78
0.0
1.2
—
—
—
0
0
22
158
1.42
0.76
1.6
2.6
10.56
10.00
g/l
0.29
14
142
54
446
1.25
0.75
3.1
1.7
—
—
—
0
0
9
54
1.68
0.75
5.1
2.1
20.70
6.64
pmol/l
—
9
54
5
25
2.01
0.73
4.0
1.2
—
—
—
0
0
5
26
1.94
0.71
1.0
1.1
—
—
—
0
0
5
26
1.94
0.71
1.4
2.4
—
—
—
0
0
10
61
1.66
0.69
1.1
1.2
—
—
—
0
0
13
191
0.67
0.69
3.9
3.3
66.71
55.17
ml/min/173m2
—
7
94
11
71
1.57
0.63
1.4
1.6
—
—
—
0
0
8
50
1.61
0.61
1.3
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
11
73
1.52
0.57
2.6
2.3
—
—
—
0
0
6
40
1.51
0.52
1.5
1.2
—
—
—
0
0
26
323
0.79
0.51
3.5
3.8
—
—
—
0
0
19
146
1.32
0.48
2.1
1.9
1.62
1.58
%
0.10
14
121
10
68
1.49
0.47
2.4
2.1
—
—
—
0
0
15
198
0.75
0.46
11.6
9.4
95.11
94.11
%
1.27
15
198
13
94
1.40
0.46
1.2
1.2
—
—
—
0
0
7
51
1.38
0.44
1.3
1.3
—
—
—
0
0
6
93
0.64
0.43
1.3
1.8
—
—
—
0
0
13
96
1.37
0.42
2.2
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.7
—
4.79
—
0
15
0
15
0.00
0.41
0.0
2.7
—
9.81
—
0
15
8
59
1.36
0.41
1.6
1.2
128.13
601.45
pmol/l
—
8
59
187
1956
0.90
0.40
33.3
26.1
331.45
329.59
g/l
1.94
187
1941
38
326
1.19
0.40
2.5
2.7
65.49
65.66
g/l
0.06
30
298
41
356
1.17
0.38
4.7
3.4
1.08
0.88
ug/l
0.62
33
254
12
89
1.36
0.38
2.1
2.1
128.86
125.39
g/l
—
7
67
88
808
1.12
0.38
4.6
4.8
0.00
0.00
estimate
-0.00
22
306
5
79
0.63
0.36
1.0
1.3
—
—
—
0
0
10
74
1.36
0.32
1.2
1.2
—
—
—
0
0
10
74
1.36
0.32
1.2
1.2
—
—
—
0
0
7
53
1.33
0.31
4.1
4.7
36.29
89.31
u/ml
—
7
53
33
373
0.87
0.27
4.2
3.1
2.14
2.00
mmol/l
0.08
28
308
23
197
1.18
0.26
1.2
1.4
—
—
—
0
0
41
455
0.89
0.26
6.5
6.2
103.24
103.49
mmol/l
0.13
41
455
5
71
0.70
0.26
1.6
1.5
—
—
—
0
0
18
209
0.85
0.21
9.3
8.4
23.68
24.51
mmol/l
0.45
18
203
0
12
0.00
0.21
0.0
1.5
—
1.13
—
0
7
0
12
0.00
0.21
0.0
1.5
—
1.33
—
0
7
0
12
0.00
0.21
0.0
1.5
—
1.11
—
0
7
6
48
1.25
0.20
4.3
2.4
11.00
9.83
mmol/l
—
6
48
10
81
1.24
0.19
1.2
1.1
—
—
—
0
0
10
121
0.82
0.18
2.2
2.7
0.00
0.00
g/l
—
10
112
26
287
0.90
0.16
2.2
2.2
34.62
33.14
u/l
0.13
21
233
9
81
1.11
0.15
1.2
1.1
—
—
—
0
0
23
254
0.90
0.15
2.3
2.2
0.28
0.45
e6/l
0.48
23
244
103
1067
0.95
0.14
5.8
4.7
0.00
0.04
estimate
1.29
20
277
31
327
0.94
0.08
2.1
2.0
16.60
8.24
umol/l
0.34
26
281
19
178
1.07
0.06
3.9
2.8
26.36
25.47
mmol/l
0.55
19
170
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
48.41
—
0
5
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
0.00
0.0
8.4
—
127.20
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.0
—
114.20
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
18.2
—
5.40
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1.19
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
113.17
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
9.43
—
0
8
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_DISORDERLENSNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DISORDERLENSNAS | 0.822 [0.71, 0.95] | 0.008 |
| Birth year | 0.991 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 1446 females with H7_DISORDERLENSNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DISORDERLENSNAS | 0.896 [0.71, 1.13] | 0.349 |
| Birth year | 0.987 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 167 out of 496 males with H7_DISORDERLENSNAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_DISORDERLENSNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.07% | 0.164% |
| 5 | 0.401% | 1.067% |
| 10 | 1.029% | 2.606% |
| 15 | 1.935% | 5.137% |
| 20 | 3.429% | 8.56% |
Relationships between endpoints
↥Index endpoint: H7_DISORDERLENSNAS – Other specified and unspecified disorders of lens
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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