No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
604 |
4. Check minimum number of eventsNone |
604 |
5. Include endpointsNone |
604 |
6. Filter based on genotype QC (FinnGen only) |
536 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H51
- Name in latin
- Convergentia insufficiens sive nimia
Similar endpoints
↥List of similar endpoints to
Convergence insufficiency and excess
based on the number of shared cases.
Similar with more cases:
- Other disorders of binocular movement
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3911 | 2548 | 1357 |
| Only index persons | 3670 | 2423 | 1247 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.04 |
| Only index persons | 0.07 | 0.09 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 19.34 | 21.03 | 16.06 |
| Only index persons | 20.89 | 22.48 | 17.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 536 | 416 | 120 |
| Unadjusted period prevalence (%) | 0.13 | 0.15 | 0.06 |
| Median age at first event (years) | 31.13 | 29.11 | 38.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 550
- Matched controls
- 5500
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H51.1
ICD-10 Finland
Convergence insufficiency and excess
+∞
307.7
550
*
H53.3
ICD-10 Finland
Other disorders of binocular vision
146.7
232.2
116
10
H50.52
ICD-10 Finland
Exophoria
153.3
86.9
90
7
H53.2
ICD-10 Finland
Diplopia
20.5
85.0
67
37
H50.31
ICD-10 Finland
Intermittent exotropia
+∞
49.7
47
*
WX704
NOMESCO Finland
Intubation
5.1
43.2
102
233
WX720
NOMESCO Finland
Own respiration
6.6
40.0
69
117
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.0
37.3
129
394
WX725
NOMESCO Finland
Noninvasive ventilation
5.8
36.2
72
140
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.7
34.4
88
213
H50.1
ICD-10 Finland
Divergent concomitant strabismus
+∞
33.7
32
*
R51.80
ICD-10 Finland
Headache
3.2
33.2
178
715
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.6
32.2
86
215
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
3.0
27.9
165
692
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
27.8
153
617
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.2
27.5
138
527
SPAT1301
SPAT
No procedures
2.7
26.9
221
1099
N03AX12
ATC
[U] gabapentin; oral
3.3
26.6
121
435
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
5.9
26.5
50
92
H52.5
ICD-10 Finland
Disorders of accommodation
+∞
25.2
24
*
WX702
NOMESCO Finland
Supraglottic ventilation device
4.6
24.2
62
149
H53.1
ICD-10 Finland
Subjective visual disturbances
4.1
22.6
67
180
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
22.2
159
727
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
22.0
21
*
AA1AD
NOMESCO Finland
CT of head and brain
2.7
21.8
158
726
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
3.7
21.2
72
213
N03AG01
ATC
valproic acid; systemic, rectal
3.9
19.8
63
178
OAB47, ,
SPAT
3.6
19.7
70
213
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.1
19.0
87
311
XLD10
NOMESCO Finland
Gynaecological examination
8.4
18.9
25
31
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.8
18.0
59
170
SPAT1263
SPAT
Sampling
2.2
17.1
277
1763
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.0
16.9
81
296
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
16.7
16
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.2
16.2
69
235
H52.1
ICD-10 Finland
Myopia
6.2
16.2
28
47
UKC02
NOMESCO Finland
Cystoscopy
3.1
16.2
75
269
SPAT1324
SPAT
Screening procedure
2.3
16.0
159
830
R20.2
ICD-10 Finland
Paraesthesia of skin
3.2
15.9
67
227
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.8
15.8
88
349
K07.60
ICD-10 Finland
Snapping jaw
3.3
15.8
65
217
H52.0
ICD-10 Finland
Hypermetropia
13.6
15.3
26
20
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.0
15.1
33
69
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.5
14.9
113
521
XA800
NOMESCO Finland
Neuropsychological investigation
3.9
14.7
45
123
XCK00
NOMESCO Finland
Perimetry
4.4
14.4
37
89
WX234
NOMESCO Finland
Paracervical blockade
3.5
14.2
52
161
A02BC03
ATC
lansoprazole; oral
2.2
14.2
153
820
37301
ICD-8 Finland
Strabismus, Concomitans divergens
+∞
13.6
13
*
XMA22
NOMESCO Finland
General examination of pregnant woman
2.8
13.4
72
279
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
3.3
13.2
52
169
TAB00
NOMESCO Finland
Lumbar puncture
3.6
12.8
43
126
SPAT1097
SPAT
Recording of ECG
2.7
12.7
76
312
H50.2
ICD-10 Finland
Vertical strabismus
71.6
12.6
14
*
XKC03
NOMESCO Finland
Water cystometry
5.4
12.6
25
48
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.2
12.6
53
179
SPAT1310
SPAT
Counselling related to known health issue
2.0
12.5
202
1250
M79.7
ICD-10 Finland
Fibromyalgia
3.9
12.2
36
96
R03BA05
ATC
fluticasone; inhalant
2.2
12.2
129
682
N01
ICPC
Headache
2.2
12.0
120
619
R02
ICPC
Shortness of breath/dyspnoea
2.5
12.0
86
385
SPAT1260
SPAT
Consultation of another employee
2.2
11.9
113
571
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.7
11.9
68
272
R42
ICD-10 Finland
Dizziness and giddiness
2.2
11.9
125
658
R03CC03
ATC
terbutaline; systemic
3.9
11.6
35
95
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.6
11.4
71
297
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
5.1
11.3
24
49
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
11.2
245
1660
SAA03
NOMESCO Finland
Extended examination of mouth
1.8
11.2
271
1895
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
11.1
112
579
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.9
11.1
55
204
N06AA09
ATC
amitriptyline; systemic
2.9
10.7
53
196
N02BF01
ATC
gabapentin; oral
2.5
10.7
70
299
G43.9
ICD-10 Finland
Migraine, unspecified
2.5
10.7
72
312
H50.51
ICD-10 Finland
Esophoria
61.2
10.7
12
*
N06AX21
ATC
duloxetine; oral
2.3
10.6
88
420
R03AC02
ATC
salbutamol; inhalant
1.8
10.5
340
2580
L12
ICPC
Hand/finger symptom/complaint
2.1
10.4
121
660
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
9.1
10.4
21
24
N06AX11
ATC
mirtazapine; oral
1.8
10.2
202
1317
N03AF01
ATC
carbamazepine; oral, rectal
3.7
10.2
33
94
A45
ICPC
General and Unspecified, Observ/health educat/advice/diet
4.5
10.1
25
58
M03BX01
ATC
baclofen; systemic
5.2
10.1
21
42
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.5
10.1
67
289
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
10.1
116
630
N03AE01
ATC
clonazepam; systemic
3.4
10.0
37
115
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.9
9.9
49
182
N89
ICPC
Migraine
2.8
9.8
50
188
R96
ICPC
Asthma
2.5
9.8
64
273
A78
ICPC
Infectious disease other/NOS
3.9
9.7
29
78
-1, ,
NOMESCO Finland
1.8
9.6
234
1616
KMAK, ,
NOMESCO Finland
1.8
9.6
327
2487
O28.8
ICD-10 Finland
Other abnormal findings on antenatal screening of mother
4.7
9.6
22
48
M35.7
ICD-10 Finland
Hypermobility syndrome
4.9
9.6
21
44
R03AC12
ATC
salmeterol; inhalant
3.8
9.6
29
79
A04
ICPC
Weakness/tiredness general
2.0
9.4
111
607
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
9.3
205
1373
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
9.1
170
1083
A01
ICPC
Pain general/multiple sites
2.4
9.0
67
304
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.2
9.0
86
434
WVA20, ,
SPAT
3.6
8.9
29
83
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
10.9
8.8
16
15
M25.5
ICD-10 Finland
Pain in joint
1.8
8.8
206
1398
-45
ICPC
Observ/health educat/advice/diet
4.0
8.8
25
65
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
8.7
211
1445
SPAT1081
SPAT
Cardiorespiratory global assessment
3.8
8.7
26
70
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
8.7
118
676
A02BC01
ATC
omeprazole; systemic
1.9
8.7
145
889
XQ855, ,
SPAT
8.4
8.6
18
22
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.2
8.6
23
57
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.2
8.6
35
116
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
8.6
181
1192
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
8.4
128
763
HAMTE, ,
NOMESCO Finland
9.7
8.3
16
17
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
8.3
110
625
R09
ICPC
Sinus symptom/complaint
2.2
8.3
78
391
N05BA01
ATC
diazepam; systemic, rectal
2.2
8.2
73
357
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
7.0
8.1
19
28
A02BA02
ATC
ranitidine; systemic
2.1
8.1
83
429
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.0
8.1
35
120
SPAT1050
SPAT
Extensive neurological examination
4.2
8.1
21
51
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.7
8.0
211
1473
WX402
NOMESCO Finland
General anaesthesia
1.8
8.0
135
829
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
8.0
132
805
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
4.1
8.0
22
56
C07AB07
ATC
bisoprolol; oral
1.7
7.9
182
1224
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
8.6
7.9
16
19
G20
ICD-10 Finland
Parkinson disease
8.6
7.9
16
19
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.8
7.8
24
66
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
6.5
7.8
19
30
C07AA05
ATC
propranolol; systemic
1.8
7.7
136
845
N02CC06
ATC
eletriptan; oral
2.9
7.7
35
124
N02CC05
ATC
almotriptan; oral
2.8
7.7
38
141
N03AX09
ATC
lamotrigine; oral
2.5
7.6
47
195
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
7.6
143
905
R44
ICPC
Respiratory, Preventive immunization/medic
9.0
7.6
15
17
F45.8
ICD-10 Finland
Other somatoform disorders
2.2
7.6
66
320
G04CA02
ATC
tamsulosin; oral
2.3
7.6
57
260
SPAT1101
SPAT
Orthostatic test
4.3
7.5
19
45
H50.9
ICD-10 Finland
Strabismus, unspecified
81.1
7.4
8
*
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
7.8
7.4
16
21
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
7.4
60
283
N02CC04
ATC
rizatriptan; oral
2.5
7.3
47
199
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
7.3
62
297
R01AD58
ATC
fluticasone, combinations; nasal
1.7
7.3
179
1219
CEC30
NOMESCO Finland
Resection of extraocular muscle
+∞
7.3
7
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
7.3
7
*
MBA20
NOMESCO Finland
Expression of placenta
6.4
7.3
18
29
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
7.3
51
225
M54.4
ICD-10 Finland
Lumbago with sciatica
1.9
7.3
112
667
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
7.2
110
652
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
4.0
7.2
20
51
R1250
NOMESCO Finland
Evaluation of functional capability
4.0
7.2
20
51
SPAT1044
SPAT
Tympanometry
3.6
7.2
23
65
R06.0
ICD-10 Finland
Dyspnoea
1.8
7.2
133
836
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
7.2
277
2114
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
3.4
7.2
26
80
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
4.2
7.1
19
47
JAETT, ,
NOMESCO Finland
12.2
7.1
12
10
M54.5
ICD-10 Finland
Low back pain
1.6
7.1
219
1582
N02AX02
ATC
tramadol; systemic, rectal
1.7
7.1
200
1412
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.7
7.0
37
142
G04BD12
ATC
mirabegron; oral
2.4
6.9
49
217
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
3.3
6.9
26
82
IBA01, ,
SPAT
3.4
6.9
25
77
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
3.0
6.9
31
109
A02BC05
ATC
esomeprazole; systemic
1.6
6.9
202
1438
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
6.9
57
271
N02AC04
ATC
dextropropoxyphene; oral
4.2
6.9
18
44
G44.2
ICD-10 Finland
Tension-type headache
1.9
6.8
99
578
W27
ICPC
Fear of complications of pregnancy
4.4
6.8
17
40
A11
ICPC
Chest pain NOS
2.4
6.8
46
200
J01MA02
ATC
ciprofloxacin; systemic
1.7
6.8
172
1178
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
3.6
6.8
22
63
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
16.9
6.8
10
6
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
6.8
225
1650
F16
ICPC
Eyelid symptom/complaint
2.6
6.8
39
157
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
6.8
38
151
P01AB01
ATC
metronidazole; oral, rectal
1.6
6.7
226
1660
L03
ICPC
Low back symptom/complaint
1.7
6.7
176
1215
N02BE01
ATC
paracetamol; systemic, rectal
2.0
6.7
479
4256
WX400
NOMESCO Finland
Inhalation anesthesy
2.7
6.7
35
134
H53.4
ICD-10 Finland
Visual field defects
6.0
6.7
17
29
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.3
6.6
25
79
N03AF02
ATC
oxcarbazepine; oral
3.1
6.6
28
95
G50.0
ICD-10 Finland
Trigeminal neuralgia
4.2
6.6
17
41
H52.2
ICD-10 Finland
Astigmatism
8.8
6.6
13
15
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
10.2
6.6
12
12
S06.0
ICD-10 Finland
Concussion
2.0
6.6
73
389
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.7
6.5
34
130
M50.3
ICD-10 Finland
Other cervical disc degeneration
5.4
6.5
18
34
SPAT1053
SPAT
Memory test
2.6
6.5
36
142
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.0
6.5
18
46
R03DC03
ATC
montelukast; oral
1.8
6.4
106
643
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.4
6.4
42
180
SXA05, ,
NOMESCO Finland
6.1
6.3
16
27
N02CC03
ATC
zolmitriptan; nasal, oral
2.4
6.3
45
200
J45.8
ICD-10 Finland
Mixed asthma
3.4
6.3
22
66
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.7
6.3
34
132
N05AH04
ATC
quetiapine; oral
1.7
6.3
119
750
H02AB06
ATC
prednisolone; systemic
1.6
6.3
230
1716
N04BC04
ATC
ropinirole; oral
18.3
6.3
9
5
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
18.3
6.3
9
5
R52.2
ICD-10 Finland
Other chronic pain
3.0
6.2
27
93
R3120
NOMESCO Finland
Training in mobility skills
27.0
6.2
8
*
N03AX11
ATC
topiramate; oral
3.2
6.2
24
77
M94.0
ICD-10 Finland
Chondrocostal junction syndrome [Tietze]
3.6
6.2
20
57
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
6.2
129
836
A06AD11
ATC
lactulose; oral
2.2
6.2
54
262
A02BC02
ATC
pantoprazole; systemic
1.6
6.2
327
2653
TKC22
NOMESCO Finland
Catheterisation instruction
7.8
6.2
13
17
R55
ICD-10 Finland
Syncope and collapse
2.2
6.1
50
236
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
2.7
6.1
32
123
K01
ICPC
Heart pain
10.2
6.1
11
11
N03AX16
ATC
[U] pregabalin
1.8
6.0
104
638
M70.2
ICD-10 Finland
Olecranon bursitis
4.0
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
232
1172
2.69
27.43
4.0
3.3
1.02
1.02
kg/l
1.71
161
764
73
193
4.21
25.25
6.6
7.0
23.75
24.65
mmol/l
1.26
68
184
161
715
2.77
24.05
4.2
3.0
41.77
241.27
ng/l
2.92
96
439
282
1749
2.26
19.34
5.8
4.4
37.32
37.00
g/l
0.50
267
1659
104
412
2.88
18.89
2.4
1.8
—
—
—
0
0
210
1177
2.27
18.15
2.5
2.0
175.62
165.67
u/l
0.06
201
1118
234
1384
2.20
17.60
3.0
2.4
63.20
58.75
u/l
0.19
221
1301
104
432
2.74
17.18
2.3
1.8
—
—
—
0
0
81
305
2.94
16.02
6.1
8.6
123.29
120.76
g/l
0.50
76
298
121
575
2.42
14.98
2.6
2.1
27.76
29.14
s
2.54
114
559
291
1974
2.01
14.27
9.3
6.2
1.22
1.21
mmol/l
0.16
264
1711
85
357
2.63
13.58
5.9
7.9
1.21
0.84
mmol/l
0.39
60
289
86
365
2.61
13.45
6.0
7.8
12.65
13.01
kpa
0.25
81
349
86
365
2.61
13.45
6.0
7.8
4.86
5.16
kpa
2.18
81
348
347
2548
1.98
13.06
7.5
4.5
6.09
6.32
mmol/l
1.70
299
2315
260
1757
1.91
12.29
8.4
5.6
1.21
1.22
mmol/l
0.33
251
1637
21
38
5.71
11.25
1.4
1.3
—
—
—
0
0
113
595
2.13
10.67
2.3
1.9
—
—
—
0
0
241
1657
1.81
10.24
4.3
3.1
27.37
29.01
u/l
0.41
227
1568
242
1666
1.81
10.24
11.2
8.4
1.11
1.12
inr
0.27
203
1363
37
116
3.35
9.91
1.2
1.4
5.07
9.77
e6/l
0.29
28
84
65
283
2.47
9.56
2.1
1.7
—
—
—
0
0
37
119
3.26
9.52
1.2
1.4
15.14
91.88
e6/l
1.50
29
91
98
517
2.09
9.12
1.6
1.6
1213.09
1202.92
nmol/l
0.04
82
398
67
308
2.34
8.73
1.5
1.4
—
—
—
0
0
275
2051
1.68
8.17
3.9
3.2
0.08
0.02
estimate
0.31
40
495
338
2687
1.67
7.64
4.1
3.4
0.00
4.99
estimate
0.80
50
584
88
476
2.01
7.60
2.7
1.8
380.09
386.93
nmol/l
0.11
81
447
74
383
2.08
7.20
1.8
1.7
—
—
—
0
0
412
3481
1.73
7.12
4.7
3.9
9.51
9.40
mm/h
0.06
404
3277
336
2707
1.62
6.85
4.2
3.4
0.06
0.01
estimate
0.43
50
555
218
1589
1.62
6.70
2.9
2.7
0.05
0.02
estimate
0.29
41
491
291
2279
1.59
6.57
5.9
5.5
9.18
10.64
umol/l
3.14
279
2159
403
3414
1.68
6.57
8.1
7.0
74.10
76.15
u/l
0.51
391
3244
17
30
5.81
6.50
2.2
2.3
—
—
—
0
0
235
1755
1.59
6.47
2.0
1.9
98.78
97.55
pmol/l
0.14
116
930
453
3979
1.79
6.27
5.8
4.5
14.52
14.43
pmol/l
0.36
436
3700
247
1881
1.57
6.17
1.9
1.9
1.31
1.34
mmol/l
0.33
237
1647
27
94
2.97
6.13
2.4
1.8
13.74
13.18
%
0.73
27
94
174
1231
1.60
5.90
2.3
2.1
2.09
2.61
mg/l
4.05
160
1067
102
632
1.75
5.72
3.3
3.0
0.83
0.82
mmol/l
0.31
97
608
23
76
3.11
5.71
1.5
1.4
—
—
—
0
0
19
57
3.42
5.49
1.2
1.6
—
—
—
0
0
148
1029
1.60
5.32
1.4
1.3
14.66
27.50
iu/ml
2.50
47
289
292
2369
1.50
5.10
3.3
2.6
—
—
estimate
—
0
0
158
1132
1.56
4.95
1.7
1.5
22.64
20.97
nmol/l
0.62
150
986
136
942
1.59
4.93
1.3
1.3
1.99
8.24
u/ml
4.12
50
390
321
2669
1.49
4.87
4.1
3.3
0.00
0.00
estimate
0.50
48
584
27
107
2.60
4.87
1.7
2.1
—
—
—
0
0
65
369
1.86
4.85
3.1
3.6
4.68
4.68
pmol/l
0.02
59
330
194
1469
1.50
4.65
1.4
1.4
0.54
1.95
u/ml
2.59
46
429
17
54
3.22
4.52
1.4
1.1
—
—
—
0
0
175
1312
1.49
4.35
1.7
1.6
—
—
—
0
0
55
308
1.87
4.29
1.7
1.6
57.08
56.55
ug/l
0.03
55
308
25
102
2.52
4.27
1.2
1.5
—
—
—
0
0
329
2789
1.45
4.26
9.9
8.7
4.04
3.99
e9/l
0.10
307
2438
60
348
1.81
4.19
1.6
1.8
—
—
—
0
0
118
821
1.56
4.14
1.7
1.6
452.45
35675362.92
pmol/l
1.32
105
726
29
129
2.32
4.13
1.2
1.6
—
—
—
0
0
152
1121
1.49
4.06
2.4
1.8
0.68
1.09
mg/l
2.43
122
850
17
58
2.99
4.04
1.4
1.1
—
—
—
0
0
328
2794
1.43
4.03
3.9
3.2
71.39
77.92
ug/l
0.48
316
2653
405
4437
0.67
3.98
11.1
10.5
93.41
92.33
ml/min/173m2
0.52
380
3985
19
448
0.40
3.92
4.8
4.0
29.33
32.05
%
0.49
12
319
27
120
2.31
3.87
1.3
1.5
—
—
—
0
0
111
776
1.54
3.80
2.1
1.9
—
—
—
0
0
11
24
4.65
3.76
1.4
2.0
1.00
1.23
nmol/l
0.45
11
19
492
4575
1.72
3.74
6.8
5.3
1.67
1.74
mu/l
1.03
479
4331
186
1448
1.43
3.70
2.7
3.0
2.33
2.35
mmol/l
2.26
175
1346
9
16
5.70
3.67
1.3
1.1
—
—
—
0
0
14
40
3.56
3.63
1.1
1.2
0.51
0.56
ratio
—
7
24
21
86
2.50
3.59
1.2
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
21
4.83
3.57
1.5
1.1
—
—
—
0
0
14
46
3.10
3.55
1.3
1.1
197.79
203.13
mg/l
0.08
14
40
22
93
2.42
3.53
2.2
1.8
171.14
206.53
pmol/l
0.67
22
87
64
405
1.66
3.31
1.3
1.3
119.92
277.43
u/ml
1.23
58
376
68
438
1.63
3.29
1.5
1.4
33.43
21.51
iu/l
1.34
61
367
15
54
2.83
3.28
1.3
1.1
—
—
—
0
0
81
1159
0.65
3.27
2.6
2.0
—
—
—
0
0
125
925
1.45
3.22
2.2
2.0
—
—
—
0
0
40
223
1.86
3.20
1.3
1.2
0.20
2.38
u/ml
—
5
12
78
524
1.57
3.18
3.7
2.4
6747.73
6556.90
u/l
0.02
35
243
13
44
3.00
3.15
1.2
1.0
—
—
—
0
0
57
355
1.68
3.14
12.2
4.3
1.97
1.48
mmol/l
0.61
51
301
69
456
1.59
3.01
13.1
7.3
105.12
104.74
mmol/l
0.26
69
456
9
21
4.34
3.00
1.4
1.0
—
—
—
0
0
42
245
1.77
2.93
1.7
1.9
—
—
—
0
0
6
9
6.72
2.87
1.7
1.3
—
—
—
0
0
6
9
6.72
2.87
1.2
1.3
209.33
61.62
ng/l
—
6
9
22
428
0.49
2.77
1.5
1.5
1.01
0.94
ratio
0.37
15
270
22
428
0.49
2.77
1.5
1.5
1.18
1.18
ratio
0.02
15
270
22
428
0.49
2.77
1.5
1.5
1.32
1.21
ratio
0.12
15
271
523
5009
1.90
2.76
12.0
9.8
25.20
25.28
u/l
0.04
516
4895
33
185
1.83
2.63
2.3
2.4
1.85
4.04
iu/l
2.24
20
79
22
420
0.50
2.62
1.5
1.5
—
—
—
0
0
448
4161
1.41
2.56
4.8
4.9
36.40
37.45
mmol/mol
2.59
433
3968
19
89
2.18
2.47
1.7
1.5
5.63
7.31
mmol/l
4.32
19
79
78
557
1.47
2.41
1.8
2.2
21.17
24.21
%
1.48
73
522
506
4826
1.61
2.39
17.6
11.8
19.46
19.97
mg/l
0.15
418
3870
6
13
4.65
2.27
1.2
1.4
—
—
—
0
0
0
60
0.00
2.25
0.0
1.1
—
—
—
0
0
385
3523
1.31
2.20
3.9
3.1
32.45
36.10
u/l
1.01
373
3380
8
24
3.37
2.18
2.6
3.0
82.88
151.63
nmol/l
—
8
24
57
396
1.49
2.03
8.1
5.4
—
—
—
0
0
45
297
1.56
2.03
4.4
6.9
6.72
7.51
mmol/l
0.54
45
284
22
120
1.87
1.95
1.2
1.1
4.20
8.36
u/ml
0.69
12
55
9
33
2.76
1.94
2.1
1.4
4.88
5.28
mmol/l
—
9
33
463
4378
1.36
1.91
4.6
4.0
5.52
5.66
mmol/l
2.62
449
4100
5
139
0.35
1.91
1.2
2.0
—
—
—
0
0
31
190
1.67
1.88
18.9
3.8
0.64
0.60
%
0.48
31
190
5
12
4.19
1.82
2.8
3.4
188.60
189.50
u/l
—
5
12
6
18
3.36
1.75
1.2
1.1
—
—
—
0
0
5
13
3.87
1.72
1.6
1.1
—
—
—
0
0
5
13
3.87
1.72
1.8
1.2
—
—
—
0
0
5
13
3.87
1.72
1.6
1.1
—
—
—
0
0
5
13
3.87
1.72
1.8
1.2
—
—
—
0
0
5
13
3.87
1.72
1.8
1.1
—
—
—
0
0
41
278
1.51
1.67
1.4
1.5
—
—
—
0
0
5
133
0.37
1.63
1.6
1.8
—
—
—
0
0
22
128
1.75
1.62
1.5
1.4
221.07
339.10
ug/g
3.25
14
76
241
2135
1.23
1.60
2.7
2.4
74.59
74.01
nmol/l
0.13
226
1976
6
20
3.02
1.58
2.0
1.8
23.83
16.71
umol/l
—
6
20
68
515
1.37
1.55
3.4
2.8
6.33
6.99
umol/l
0.09
54
441
26
161
1.65
1.55
1.5
1.4
0.17
0.39
nmol/l
3.82
18
133
0
44
0.00
1.52
0.0
1.1
—
34.40
—
0
5
11
51
2.18
1.51
1.2
1.4
—
—
—
0
0
540
5300
2.04
1.45
26.2
18.4
263.92
261.43
e9/l
0.40
540
5231
22
133
1.68
1.44
1.2
1.1
2.85
3.75
u/ml
0.16
14
69
5
16
3.14
1.44
1.2
1.3
—
—
—
0
0
540
5301
2.03
1.43
26.1
18.3
89.69
90.09
fl
1.39
540
5268
9
41
2.21
1.37
1.4
2.0
—
—
—
0
0
6
23
2.63
1.37
1.3
2.6
252.17
475.70
u/ml
—
6
23
17
97
1.78
1.36
3.1
4.9
—
554.64
—
0
11
5
17
2.96
1.36
1.2
1.2
—
—
—
0
0
59
452
1.34
1.28
4.5
4.0
21.73
22.15
%
0.06
19
196
158
1371
1.21
1.24
2.9
3.3
7.91
8.18
mmol/l
0.27
149
1191
18
108
1.69
1.23
1.2
1.1
0.01
0.28
u/ml
—
9
36
10
49
2.06
1.22
1.0
1.4
—
—
—
0
0
479
4616
1.29
1.22
4.8
4.6
2.81
2.80
mmol/l
0.08
468
4392
5
19
2.65
1.22
1.0
1.1
80.00
95.58
%
—
5
19
43
316
1.39
1.21
15.3
3.8
4.74
4.65
kpa
0.11
43
306
475
4574
1.28
1.21
4.4
4.2
4.76
4.72
mmol/l
0.39
462
4371
8
38
2.12
1.19
1.5
2.0
—
—
—
0
0
0
36
0.00
1.14
0.0
3.9
—
—
—
0
0
8
41
1.97
1.09
1.0
1.1
104.13
113.56
pmol/l
—
8
41
7
32
2.20
1.08
1.7
2.4
—
—
—
0
0
16
97
1.67
1.07
1.4
1.5
—
—
—
0
0
15
240
0.61
1.06
1.9
1.4
—
—
—
0
0
64
513
1.28
1.03
1.5
1.5
—
—
—
0
0
11
189
0.57
1.02
2.1
1.7
—
—
—
0
0
172
1531
1.18
1.01
2.0
1.8
—
—
—
0
0
22
148
1.51
0.99
1.2
1.3
—
—
—
0
0
30
409
0.72
0.98
3.6
2.8
—
—
—
0
0
9
50
1.81
0.97
1.1
1.3
—
—
—
0
0
7
37
1.90
0.94
1.6
1.1
10.00
9.05
mm/h
—
7
37
17
111
1.55
0.88
1.2
1.1
—
—
—
0
0
409
3917
1.17
0.88
4.2
3.8
—
—
—
0
0
15
95
1.60
0.88
2.3
2.2
136.67
131.52
g/l
0.59
15
77
117
1025
1.18
0.83
2.5
2.5
304.21
313.26
umol/l
0.54
105
921
54
660
0.80
0.83
2.9
2.6
2.29
3.12
e6/l
0.67
18
294
0
26
0.00
0.78
0.0
1.6
—
—
—
0
0
22
157
1.42
0.78
1.3
1.1
0.24
1.48
u/ml
2.56
14
88
17
115
1.49
0.77
1.3
2.0
2.35
2.98
g/l
2.18
17
108
45
360
1.27
0.77
1.0
1.0
—
—
—
0
0
469
4559
1.20
0.76
4.2
4.1
1.46
1.49
mmol/l
0.61
457
4332
11
67
1.65
0.75
2.1
1.5
—
—
—
0
0
5
24
2.09
0.74
1.0
1.0
0.06
0.34
u/ml
—
5
24
30
228
1.33
0.74
1.8
1.8
3.82
5.05
iu/ml
—
6
53
123
1374
0.87
0.72
1.9
2.3
—
—
—
0
0
14
94
1.50
0.67
1.4
1.6
—
—
—
0
0
13
87
1.51
0.63
1.9
2.5
0.73
1.00
nmol/l
0.80
13
79
17
121
1.42
0.63
1.3
1.9
3.28
3.72
g/l
1.01
17
114
17
121
1.42
0.63
1.3
1.9
6.97
7.31
g/l
0.54
17
114
157
1442
1.12
0.59
3.6
3.0
13.40
79.72
ng/l
0.72
74
789
15
106
1.43
0.58
3.1
2.7
—
—
—
0
0
123
1119
1.13
0.54
3.5
4.2
2.88
9.36
mg/mmol
3.16
70
696
11
75
1.48
0.51
1.2
1.1
—
—
—
0
0
42
354
1.20
0.49
2.6
2.4
8.68
17.84
au/ml
—
5
38
63
715
0.87
0.48
2.7
2.4
0.58
0.86
e6/l
0.84
27
348
18
137
1.32
0.48
1.1
1.9
1.38
1.31
g/l
0.08
12
119
15
199
0.75
0.47
8.3
9.3
23.52
24.21
mmol/l
0.54
15
191
23
182
1.28
0.47
1.2
1.5
0.02
0.45
iu/ml
—
7
24
7
49
1.43
0.46
1.0
1.2
—
88.57
—
0
7
59
517
1.16
0.46
1.3
1.3
90.73
155.24
u/ml
1.35
34
214
16
121
1.33
0.44
1.3
1.9
4.27
4.37
g/l
0.27
16
114
12
88
1.37
0.40
8.0
4.3
3.84
3.85
mmol/l
0.01
12
88
117
1261
0.91
0.39
1.7
2.1
—
—
—
0
0
11
80
1.38
0.38
1.1
1.5
—
—
—
0
0
21
171
1.24
0.36
1.1
1.2
—
22.74
—
0
8
22
181
1.22
0.35
1.2
1.3
—
—
—
0
0
21
254
0.82
0.34
7.1
3.8
5.30
5.12
kpa
0.69
21
245
114
1221
0.92
0.34
3.5
2.6
0.10
0.33
e6/l
3.84
81
847
14
109
1.29
0.33
1.4
2.0
10.13
10.70
g/l
0.28
14
101
12
154
0.77
0.32
1.4
1.6
—
—
—
0
0
22
185
1.20
0.29
1.3
1.1
0.31
3.81
u/ml
3.72
15
106
7
56
1.25
0.29
1.0
1.1
—
—
—
0
0
8
63
1.27
0.28
1.1
1.3
—
—
—
0
0
8
63
1.27
0.28
1.1
1.3
—
—
—
0
0
11
139
0.79
0.27
1.0
1.3
—
—
—
0
0
8
66
1.22
0.27
1.0
1.7
—
—
—
0
0
13
104
1.26
0.26
1.0
1.1
—
—
—
0
0
435
4283
1.07
0.26
3.4
3.6
1.28
1.21
mmol/l
0.98
422
4049
29
329
0.87
0.25
1.3
1.4
195.83
256.03
miu/ml
—
9
178
27
236
1.15
0.24
1.4
1.8
—
—
—
0
0
6
84
0.71
0.24
2.2
1.3
—
—
—
0
0
5
38
1.32
0.23
1.8
1.7
—
1224680.00
—
0
5
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
23
262
0.87
0.21
1.4
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
13.72
—
0
11
0
12
0.00
0.21
0.0
2.4
—
—
—
0
0
31
345
0.89
0.21
2.5
2.9
0.41
0.73
ug/l
4.69
14
195
0
13
0.00
0.21
0.0
1.2
—
1.69
—
0
8
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
21
240
0.87
0.20
1.5
1.3
—
—
—
0
0
12
144
0.83
0.20
1.6
1.2
—
—
—
0
0
13
109
1.20
0.18
1.4
1.2
—
—
—
0
0
8
68
1.18
0.16
1.5
2.5
—
—
—
0
0
28
308
0.90
0.16
2.3
2.4
64.33
76.67
ml/min/173m2
1.47
12
124
15
130
1.16
0.15
1.3
1.3
284.90
226.07
u/ml
—
10
76
24
216
1.12
0.15
2.2
1.3
—
—
—
0
0
8
73
1.10
0.15
1.1
2.4
4.89
6.43
pmol/l
—
8
73
140
1447
0.96
0.15
4.9
3.4
0.00
0.01
estimate
1.08
49
562
77
736
1.05
0.13
1.8
1.8
3.72
3.39
ratio
1.20
51
553
25
271
0.92
0.11
1.2
1.2
0.93
0.88
g/l
0.53
25
271
136
1395
0.97
0.11
3.4
2.8
21.52
130.31
e6/l
1.33
106
1018
13
146
0.89
0.10
1.5
1.2
—
—
—
0
0
11
96
1.15
0.10
1.0
1.0
1.26
2.11
eliau/ml
—
5
47
5
47
1.06
0.09
1.0
1.1
—
—
—
0
0
5
47
1.06
0.09
1.0
1.1
—
—
—
0
0
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
5
48
1.04
0.09
1.0
1.4
—
—
—
0
0
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
20
216
0.92
0.08
10.3
9.7
1.22
1.38
%
0.39
20
216
12
107
1.12
0.08
1.0
1.3
1.60
5.51
u/ml
—
5
37
7
68
1.03
0.08
1.4
1.4
—
—
—
0
0
25
266
0.94
0.07
1.2
1.1
1.50
1.54
g/l
0.43
25
266
6
71
0.84
0.07
1.2
1.8
—
—
—
0
0
60
582
1.03
0.06
1.5
1.7
3.58
3.42
mmol/l
0.50
35
398
12
109
1.10
0.06
1.0
1.3
5.17
6.85
u/ml
—
6
48
28
291
0.96
0.04
3.9
4.3
2.25
21.59
ug/l
0.68
15
226
26
270
0.96
0.03
1.5
1.6
0.20
0.29
mg/l
—
7
117
11
102
1.08
0.03
2.2
2.1
677.50
201.49
ug/l
0.33
11
95
20
208
0.96
0.02
2.0
1.6
2.29
8.24
u/ml
—
7
54
33
338
0.97
0.01
1.3
1.4
—
—
—
0
0
73
738
0.99
0.01
2.3
2.2
2.39
2.42
mmol/l
1.64
67
649
89
882
1.01
0.01
2.9
3.0
471.37
754.07
ng/l
1.11
66
719
10
106
0.94
0.01
2.1
2.6
0.80
1.82
index
—
5
55
21
207
1.02
0.00
9.8
10.0
0.67
0.65
%
0.08
21
207
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
7.44
—
0
7
5
49
1.02
-0.00
1.0
1.4
—
—
—
0
0
5
57
0.88
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
56
0.89
-0.00
1.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
1.20
—
0
9
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
0.67
—
0
6
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
1.21
—
0
6
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
—
—
0
0
12
120
1.00
-0.00
1.3
1.3
—
—
—
0
0
8
88
0.91
-0.00
1.6
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CONVERGINSUFF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONVERGINSUFF | 0.934 [0.75, 1.17] | 0.547 |
| Birth year | 0.992 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 2408 females with H7_CONVERGINSUFF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONVERGINSUFF | 1.371 [1.07, 1.76] | 0.012 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 1274 males with H7_CONVERGINSUFF died.
Mortality risk
Mortality risk for people of age
years, who have H7_CONVERGINSUFF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.065% | 0.274% |
| 5 | 0.501% | 1.774% |
| 10 | 1.179% | 4.347% |
| 15 | 2.336% | 8.311% |
| 20 | 4.254% | 13.689% |
Relationships between endpoints
↥Index endpoint: H7_CONVERGINSUFF – Convergence insufficiency and excess
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data