No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
589 |
4. Check minimum number of eventsNone |
589 |
5. Include endpointsNone |
589 |
6. Filter based on genotype QC (FinnGen only) |
514 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H53
- Name in latin
- Aliae perturbationes visus binocularis
Similar endpoints
↥List of similar endpoints to
Other disorders of binocular vision
based on the number of shared cases.
Similar with more cases:
- Visual disturbances
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4069 | 2676 | 1389 |
| Only index persons | 3914 | 2593 | 1321 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.08 | 0.04 |
| Only index persons | 0.08 | 0.10 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 24.72 | 24.46 | 25.21 |
| Only index persons | 25.18 | 24.84 | 25.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 514 | 394 | 120 |
| Unadjusted period prevalence (%) | 0.12 | 0.14 | 0.06 |
| Median age at first event (years) | 34.60 | 31.84 | 43.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 532
- Matched controls
- 5320
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H53.3
ICD-10 Finland
Other disorders of binocular vision
4503599627370496.0
307.7
528
*
H51.1
ICD-10 Finland
Convergence insufficiency and excess
374.5
120.5
117
*
H50.52
ICD-10 Finland
Exophoria
38.8
108.8
68
20
H53.1
ICD-10 Finland
Subjective visual disturbances
12.9
70.5
72
64
WX704
NOMESCO Finland
Intubation
6.3
59.2
115
223
WX725
NOMESCO Finland
Noninvasive ventilation
7.2
53.5
87
140
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
53.5
168
490
H53.2
ICD-10 Finland
Diplopia
104.1
51.9
56
6
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
7.3
40.4
63
96
SPAT1301
SPAT
No procedures
3.1
35.9
237
1086
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.9
35.5
125
386
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.8
34.4
87
209
WX720
NOMESCO Finland
Own respiration
6.1
34.3
64
117
TPH04
NOMESCO Finland
Cathetrisation of vein
3.3
32.3
160
614
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
31.6
169
677
N03AX12
ATC
[U] gabapentin; oral
3.5
29.9
124
424
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.9
29.1
99
296
SPAT1324
SPAT
Screening procedure
2.9
26.8
177
789
SPAT1263
SPAT
Sampling
2.6
26.3
292
1684
H53.9
ICD-10 Finland
Visual disturbance, unspecified
9.1
24.8
31
36
R51.80
ICD-10 Finland
Headache
2.9
24.6
154
663
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
3.9
23.5
75
213
WX702
NOMESCO Finland
Supraglottic ventilation device
4.4
22.5
60
149
A02BC03
ATC
lansoprazole; oral
2.6
20.7
166
801
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.9
19.6
63
179
R03BA08
ATC
ciclesonide; inhalant
3.3
18.9
77
256
OAB47, ,
SPAT
3.6
18.2
66
204
R02
ICPC
Shortness of breath/dyspnoea
2.9
17.9
93
357
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.6
17.0
61
187
SPAT1097
SPAT
Recording of ECG
3.1
16.6
78
282
H53.0
ICD-10 Finland
Amblyopia ex anopsia
62.0
15.8
18
*
N02BF01
ATC
gabapentin; oral
3.0
15.8
77
284
AA1AD
NOMESCO Finland
CT of head and brain
2.4
15.3
138
690
A02BC05
ATC
esomeprazole; systemic
2.1
15.3
222
1346
R96
ICPC
Asthma
3.1
15.1
69
245
A45
ICPC
General and Unspecified, Observ/health educat/advice/diet
5.6
15.1
29
54
XCK00
NOMESCO Finland
Perimetry
4.5
15.0
37
86
H53.4
ICD-10 Finland
Visual field defects
58.4
14.9
17
*
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.5
14.9
110
503
-, ,
ICD-10 Finland
11.3
14.7
27
25
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.7
14.6
85
345
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
3.4
14.4
55
175
LX2A3, ,
SPAT
3.8
14.3
45
126
SPAT1310
SPAT
Counselling related to known health issue
2.1
14.0
205
1237
R42
ICD-10 Finland
Dizziness and giddiness
2.3
14.0
123
607
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.7
13.9
45
128
H50.31
ICD-10 Finland
Intermittent exotropia
11.3
13.6
25
23
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.0
13.5
66
243
R03CC03
ATC
terbutaline; systemic
4.3
13.5
36
89
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.0
13.4
63
227
N06AX21
ATC
duloxetine; oral
2.6
13.3
89
386
XMA22
NOMESCO Finland
General examination of pregnant woman
2.9
13.3
67
251
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.8
13.3
70
269
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.2
12.7
129
673
R09
ICPC
Sinus symptom/complaint
2.5
12.7
87
382
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
12.6
109
531
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.3
12.6
51
168
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
17.9
12.6
19
11
WX234
NOMESCO Finland
Paracervical blockade
3.4
12.4
47
149
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
9.3
12.4
25
28
H50.1
ICD-10 Finland
Divergent concomitant strabismus
38.5
12.3
15
*
H50.2
ICD-10 Finland
Vertical strabismus
27.4
12.1
16
6
R03AC02
ATC
salbutamol; inhalant
1.9
12.1
335
2479
SAA03
NOMESCO Finland
Extended examination of mouth
1.9
12.0
264
1809
N02AX02
ATC
tramadol; systemic, rectal
1.9
12.0
210
1334
H02AB06
ATC
prednisolone; systemic
1.9
11.9
246
1652
D07AB02
ATC
hydrocortisone butyrate; topical
2.0
11.8
178
1074
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
11.6
206
1311
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.4
11.6
91
424
SPAT1260
SPAT
Consultation of another employee
2.2
11.4
108
546
H04.10
ICD-10 Finland
Dry eye syndrome
2.4
11.2
81
364
SPAT1058
SPAT
PEF monitoring instruction
3.0
11.1
50
176
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.8
11.1
25
54
CEC00
NOMESCO Finland
Recession of extraocular muscle
44.3
11.0
13
*
SPAT1044
SPAT
Tympanometry
4.4
10.9
28
67
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
10.9
137
771
SPAT1081
SPAT
Cardiorespiratory global assessment
4.1
10.9
30
76
N06AX11
ATC
mirtazapine; oral
1.9
10.8
197
1259
N03AF02
ATC
oxcarbazepine; oral
4.0
10.8
31
81
G44.2
ICD-10 Finland
Tension-type headache
2.2
10.6
104
532
MBC10
NOMESCO Finland
Repair of obstetric laceration of vagina
3.4
10.5
38
117
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.7
10.4
60
241
N03AE01
ATC
clonazepam; systemic
3.4
10.3
38
118
H50.51
ICD-10 Finland
Esophoria
23.9
10.3
14
6
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.8
10.3
53
201
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
3.9
10.2
30
80
A31
ICPC
General and Unspecified, Medical examin/health eval partial
3.8
10.1
31
85
F05
ICPC
Visual disturbance other
4.2
10.1
27
67
A78
ICPC
Infectious disease other/NOS
4.0
10.1
29
76
N03AG01
ATC
valproic acid; systemic, rectal
2.9
10.0
48
175
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.4
9.7
19
36
K07.60
ICD-10 Finland
Snapping jaw
2.7
9.6
52
202
R01AD09
ATC
mometasone; nasal
1.8
9.5
275
2002
N06AA09
ATC
amitriptyline; systemic
2.8
9.5
50
192
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.4
9.5
24
57
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.1
9.5
110
599
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.5
9.4
62
266
R01AD58
ATC
fluticasone, combinations; nasal
1.8
9.4
181
1167
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.2
9.4
87
434
R03AK08
ATC
formoterol and beclometasone; inhalant
3.3
9.3
35
110
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
9.2
227
1573
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.3
9.2
35
111
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.3
9.1
35
112
S06.0
ICD-10 Finland
Concussion
2.3
8.8
74
354
UJF32
NOMESCO Finland
Coloscopy
2.0
8.8
110
614
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
3.6
8.8
29
84
TPH07
NOMESCO Finland
Cathetrisation of artery
2.7
8.8
49
194
WX402
NOMESCO Finland
General anaesthesia
1.9
8.7
129
762
D02
ICPC
Abdominal pain epigastric
2.6
8.7
50
201
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.2
8.6
75
364
D06
ICPC
Abdominal pain localized other
2.3
8.5
65
298
M01AH03
ATC
valdecoxib; oral
3.3
8.5
32
101
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.1
8.5
84
430
G03DB01
ATC
dydrogesterone; oral
2.1
8.4
87
452
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.1
8.4
35
118
G54.0
ICD-10 Finland
Brachial plexus disorders
3.6
8.4
27
77
A02BA02
ATC
ranitidine; systemic
2.1
8.3
84
434
Z31.5
ICD-10 Finland
Genetic counselling
2.6
8.2
49
200
M47.9
ICD-10 Finland
Spondylosis, unspecified
4.9
8.2
18
38
SAA04
NOMESCO Finland
Special examination of mouth
2.7
7.9
43
168
C07AA05
ATC
propranolol; systemic
1.8
7.9
131
802
N03AX16
ATC
[U] pregabalin
1.9
7.8
110
638
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.3
7.8
61
283
A04
ICPC
Weakness/tiredness general
1.9
7.8
102
577
ZXE00
NOMESCO Finland
One hour or less
0.5
7.8
81
1410
R20.2
ICD-10 Finland
Paraesthesia of skin
2.5
7.8
49
206
H52.0
ICD-10 Finland
Hypermetropia
4.4
7.7
19
44
H52.5
ICD-10 Finland
Disorders of accommodation
45.7
7.7
9
*
J01EA01
ATC
trimethoprim; systemic
1.8
7.7
145
920
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
7.6
104
596
-1, ,
NOMESCO Finland
1.7
7.6
222
1590
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
7.6
221
1583
SPAT1153
SPAT
Removal of sutures
1.8
7.6
138
867
R03BA01
ATC
beclometasone; inhalant
2.1
7.5
78
405
KMAK, ,
NOMESCO Finland
1.7
7.5
301
2337
J01DA09
ATC
[U] cefadroxil
1.8
7.5
149
959
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
4.3
7.5
19
45
M01AH01
ATC
celecoxib; oral
2.1
7.5
79
413
N03AX11
ATC
topiramate; oral
3.5
7.5
26
78
C07AB07
ATC
bisoprolol; oral
1.7
7.4
184
1261
R06AX27
ATC
desloratadine; oral
1.7
7.3
198
1387
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
7.3
158
1041
F45.8
ICD-10 Finland
Other somatoform disorders
2.2
7.3
61
291
JN3AD
NOMESCO Finland
Abdominal CT examination
2.2
7.3
65
319
HAMTE, ,
NOMESCO Finland
7.5
7.2
16
22
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.7
7.2
23
65
S01GX08
ATC
ketotifen; ophthalmic
2.7
7.2
38
146
TAB00
NOMESCO Finland
Lumbar puncture
3.0
7.2
32
112
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
7.1
59
280
JAH01
NOMESCO Finland
Laparoscopy
2.9
7.1
33
118
M25.5
ICD-10 Finland
Pain in joint
1.7
7.1
187
1299
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.5
7.1
45
190
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
4.5
7.0
17
39
WX400
NOMESCO Finland
Inhalation anesthesy
2.8
7.0
34
125
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
6.0
7.0
18
31
D01
ICPC
Abdominal pain/cramps general
1.9
6.9
92
522
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.0
6.9
31
109
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
6.9
218
1586
N04BC05
ATC
pramipexole; oral
2.7
6.9
37
144
R06AX22
ATC
ebastine; oral
1.9
6.8
101
593
R55
ICD-10 Finland
Syncope and collapse
2.3
6.8
53
245
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
11.1
6.8
12
11
R44
ICPC
Respiratory, Preventive immunization/medic
9.5
6.8
13
14
A30
ICPC
General and Unspecified, Medical examin/health eval complete
3.7
6.8
21
58
M79.7
ICD-10 Finland
Fibromyalgia
3.0
6.8
29
99
M54.2
ICD-10 Finland
Cervicalgia
2.2
6.8
56
266
L12
ICPC
Hand/finger symptom/complaint
1.8
6.7
108
651
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.4
6.7
45
195
XA800
NOMESCO Finland
Neuropsychological investigation
2.9
6.7
31
111
XPX04
NOMESCO Finland
Angioscopy
22.8
6.7
9
*
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
6.7
122
764
L86
ICPC
Back syndrome with radiating pain
2.6
6.7
40
164
A02BX02
ATC
sucralfate; oral
4.1
6.7
18
45
N05BA01
ATC
diazepam; systemic, rectal
2.1
6.7
67
344
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
5.6
6.7
18
33
A11
ICPC
Chest pain NOS
2.5
6.7
43
183
J01AA02
ATC
doxycycline; systemic
1.7
6.6
375
3133
C09CA06
ATC
candesartan; oral
1.8
6.6
112
687
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
6.5
115
712
N06AB10
ATC
escitalopram; oral
1.7
6.5
143
942
-31
ICPC
Medical examin/health eval partial
2.5
6.5
40
166
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.0
6.5
28
96
R49.01
ICD-10 Finland
Functional dysphonia
3.3
6.5
24
75
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.9
6.5
29
102
N06AX26
ATC
vortioxetine; oral
2.2
6.4
58
286
XQ848
NOMESCO Finland
Dermatological photography
3.5
6.3
21
61
DJD20
NOMESCO Finland
Plastic repair of septum of nose
3.4
6.3
22
66
N03AX09
ATC
lamotrigine; oral
2.5
6.3
41
175
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
6.3
163
1122
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
6.2
103
626
M50.3
ICD-10 Finland
Other cervical disc degeneration
4.1
6.2
17
43
WX872
NOMESCO Finland
Intensive care
3.5
6.2
21
62
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
5.9
6.2
16
28
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
6.2
61
311
SPAT1307
SPAT
Psychosocial counselling and guidance
2.1
6.2
61
311
E0000UV, ,
ATC
1.6
6.2
226
1690
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.7
6.2
134
880
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
6.2
186
1329
L04AX01
ATC
azathioprine; systemic
3.0
6.1
27
94
A02BC01
ATC
omeprazole; systemic
1.7
6.1
130
849
R03DC03
ATC
montelukast; oral
1.8
6.1
101
614
R52.1
ICD-10 Finland
Chronic intractable pain
8.7
6.1
12
14
G43.3
ICD-10 Finland
Complicated migraine
3.3
6.1
22
68
SPAT1240
SPAT
Therapeutic discussion
1.9
6.0
83
476
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
250
1143
3.24
38.59
4.4
3.2
1.02
1.02
kg/l
1.93
173
750
84
195
4.93
34.62
3.0
2.6
66.95
116.59
ng/l
1.43
77
170
166
679
3.10
29.74
4.1
3.0
37.89
269.97
ng/l
2.14
95
410
105
403
3.00
20.34
2.3
1.8
—
—
—
0
0
232
1314
2.36
20.18
3.2
2.4
53.60
62.01
u/l
1.24
223
1235
105
416
2.90
19.14
2.2
1.8
—
—
—
0
0
205
1123
2.34
19.02
3.1
2.0
117.57
246.17
u/l
1.43
200
1072
89
333
3.01
17.92
4.7
8.7
1.85
0.99
mmol/l
1.39
65
272
114
515
2.54
15.87
2.0
2.3
27.61
28.97
s
2.11
107
501
424
3278
2.45
15.62
5.4
3.9
10.10
9.30
mm/h
0.65
417
3101
259
1663
2.09
15.30
7.0
4.3
36.92
36.93
g/l
0.01
249
1580
339
2420
2.10
14.86
5.1
4.4
6.08
6.35
mmol/l
2.35
303
2204
278
1857
2.04
14.48
7.1
6.3
1.21
1.22
mmol/l
0.91
256
1610
75
289
2.86
14.20
1.4
1.4
—
—
—
0
0
118
585
2.31
13.18
2.2
1.9
—
—
—
0
0
279
1933
1.93
12.41
4.2
3.1
0.00
0.03
estimate
1.87
32
442
24
45
5.54
12.40
1.2
1.7
—
—
—
0
0
241
1598
1.93
12.16
11.0
9.0
1.14
1.13
inr
0.05
216
1328
27
62
4.53
11.10
1.6
1.5
—
—
—
0
0
296
2139
1.87
11.10
6.2
5.7
9.34
10.24
umol/l
1.83
286
2041
403
3222
2.03
11.08
8.7
7.1
70.16
74.34
u/l
2.14
392
3055
29
71
4.26
11.01
1.3
1.5
—
—
—
0
0
82
377
2.39
10.76
6.7
5.5
—
—
—
0
0
80
366
2.40
10.61
1.5
1.3
114.41
225.19
u/ml
1.31
73
342
239
1649
1.82
10.11
5.4
5.8
1.20
1.22
mmol/l
1.96
233
1535
332
2545
1.81
9.70
4.5
3.4
0.08
0.01
estimate
0.44
37
507
329
2524
1.80
9.50
4.6
3.4
0.00
3.05
estimate
0.50
36
532
60
260
2.47
8.93
1.7
1.6
—
—
—
0
0
29
84
3.59
8.77
1.3
1.5
—
—
—
0
0
444
3797
2.02
8.44
5.9
4.4
14.49
14.40
pmol/l
0.38
429
3545
33
109
3.16
8.15
1.4
1.6
—
—
—
0
0
221
1573
1.69
7.82
4.6
3.0
26.58
28.26
u/l
0.41
215
1504
82
438
2.03
7.35
4.5
6.2
104.44
104.45
mmol/l
0.01
82
438
333
2665
1.67
7.31
3.9
3.2
75.83
80.97
ug/l
0.35
327
2542
16
22
7.46
7.23
3.1
2.3
—
—
—
0
0
491
4430
2.41
7.09
18.6
12.4
139.76
139.61
mmol/l
0.89
485
4344
28
92
3.16
6.99
2.8
1.9
13.67
13.11
%
0.88
28
92
89
498
1.95
6.98
2.6
2.2
5597.93
6038.54
u/l
0.06
27
212
101
590
1.88
6.96
3.4
3.3
0.83
0.82
mmol/l
0.41
96
566
315
2503
1.63
6.95
4.4
3.4
0.00
0.00
estimate
0.50
37
533
125
783
1.78
6.86
1.6
1.6
124576757.05
54257278.28
pmol/l
0.35
118
693
168
1154
1.67
6.57
2.6
2.1
2.19
2.66
mg/l
2.65
157
994
284
2219
1.60
6.57
3.4
2.7
—
—
estimate
—
0
0
482
4345
2.16
6.48
7.0
5.3
1.73
1.76
mu/l
0.26
471
4126
489
4437
2.26
6.40
18.9
12.5
3.92
3.92
mmol/l
0.01
483
4335
145
971
1.68
6.20
1.4
1.3
18.85
27.47
iu/ml
0.89
58
280
66
349
2.02
6.06
4.0
3.6
4.72
4.56
pmol/l
0.67
60
311
38
160
2.48
6.03
2.4
2.1
1.71
4.10
iu/l
2.27
26
69
28
102
2.84
5.88
1.4
1.5
—
—
—
0
0
79
450
1.89
5.85
2.2
1.9
351.51
386.85
nmol/l
0.77
74
429
53
264
2.12
5.71
1.8
2.1
—
—
—
0
0
17
36
4.84
5.65
1.1
1.2
127.65
106.17
pmol/l
0.58
17
36
57
298
2.02
5.41
1.7
1.8
—
—
—
0
0
314
2577
1.53
5.39
11.4
9.0
4.04
3.96
e9/l
0.26
297
2251
132
895
1.63
5.29
1.3
1.3
7.10
7.07
u/ml
0.00
55
352
65
1090
0.54
5.19
2.4
2.0
—
—
—
0
0
62
339
1.94
5.18
1.5
1.6
—
—
—
0
0
231
1793
1.51
5.06
2.0
1.9
1.38
1.34
mmol/l
0.30
226
1573
50
258
2.04
4.92
1.5
1.5
57.49
56.85
ug/l
0.03
50
258
221
1709
1.50
4.88
2.1
1.9
94.88
96.72
pmol/l
0.21
111
908
495
4591
2.12
4.83
18.3
11.9
18.95
20.68
mg/l
0.71
420
3694
85
526
1.73
4.78
1.6
1.6
1179.06
1166.04
nmol/l
0.05
76
420
28
117
2.47
4.55
1.5
2.0
—
—
—
0
0
195
1497
1.48
4.35
3.1
2.7
0.00
0.02
estimate
1.34
32
440
148
1076
1.52
4.29
1.7
1.6
22.78
20.65
nmol/l
0.82
141
945
44
233
1.97
4.06
1.5
1.4
—
—
—
0
0
13
31
4.27
4.03
1.2
1.2
0.63
0.51
ratio
—
8
20
15
384
0.37
3.75
1.8
1.5
—
—
—
0
0
105
728
1.55
3.74
2.6
1.9
—
—
—
0
0
12
29
4.21
3.72
1.2
1.1
1995.92
1305.83
miu/ml
0.96
12
29
12
29
4.21
3.72
1.1
1.1
0.95
1.18
u/l
—
6
13
14
45
3.17
3.67
1.1
1.1
—
—
—
0
0
9
16
5.70
3.67
1.6
1.9
76.27
56.24
ug/l
—
9
16
16
392
0.39
3.63
1.8
1.5
1.14
1.16
ratio
0.05
11
253
16
392
0.39
3.63
1.8
1.5
1.18
1.18
ratio
0.01
11
254
16
392
0.39
3.63
1.8
1.5
0.94
0.95
ratio
0.07
11
253
184
1437
1.43
3.62
1.8
1.7
—
—
—
0
0
14
46
3.10
3.55
1.1
1.1
—
—
—
0
0
22
94
2.40
3.45
1.2
1.1
—
—
—
0
0
12
32
3.81
3.41
1.2
1.1
—
—
—
0
0
503
4771
2.00
3.35
13.4
9.8
24.84
25.05
u/l
0.13
497
4666
174
1364
1.41
3.30
3.4
3.0
2.32
2.36
mmol/l
2.73
164
1267
374
3329
1.42
3.30
3.7
3.0
33.75
36.59
u/l
0.68
365
3211
452
4182
1.54
3.15
4.8
4.0
5.59
5.68
mmol/l
0.82
441
3926
164
1287
1.40
3.06
3.0
3.2
7.56
7.97
mmol/l
0.43
154
1125
434
3998
1.46
2.93
5.0
4.9
36.73
37.49
mmol/mol
1.37
426
3806
38
631
0.57
2.85
3.6
2.7
1.55
3.17
e6/l
1.83
16
293
393
4248
0.71
2.85
11.7
10.8
90.81
91.80
ml/min/173m2
0.46
359
3803
154
1209
1.39
2.84
1.6
1.6
—
—
—
0
0
16
66
2.47
2.73
1.2
1.5
—
—
—
0
0
12
40
3.05
2.71
1.1
1.1
—
—
—
0
0
37
215
1.77
2.63
2.5
1.8
3.51
4.44
iu/ml
—
9
50
8
20
4.04
2.57
1.3
1.1
—
—
—
0
0
5
7
7.20
2.55
1.4
1.1
—
—
—
0
0
89
650
1.44
2.45
2.2
2.1
12.60
14.56
umol/l
1.63
84
603
6
12
5.04
2.41
1.3
1.3
156.83
58.23
ng/l
—
6
12
17
77
2.25
2.40
2.0
1.5
6.31
7.50
mmol/l
1.88
17
65
130
1021
1.36
2.35
2.2
1.9
1.03
0.97
mg/l
0.08
104
771
113
870
1.38
2.31
2.7
2.1
—
—
—
0
0
49
320
1.59
2.29
2.1
3.8
1.86
1.61
mmol/l
0.22
40
268
8
23
3.51
2.27
1.0
1.1
0.30
4.27
u/ml
—
8
23
133
1054
1.35
2.27
3.3
4.1
3.51
10.49
mg/mmol
2.89
81
665
69
489
1.47
2.23
1.1
1.3
53.92
166.90
u/ml
5.63
33
204
232
1997
1.29
2.16
3.0
2.4
76.31
74.21
nmol/l
0.58
226
1856
66
469
1.46
2.11
1.5
1.4
—
—
—
0
0
42
272
1.59
2.05
3.4
6.3
6.70
8.01
mmol/l
0.88
42
264
11
44
2.53
2.02
1.1
1.2
—
—
—
0
0
102
1288
0.74
1.97
2.3
2.4
—
—
—
0
0
163
1359
1.29
1.91
3.3
3.1
11.48
83.82
ng/l
0.73
71
735
31
194
1.63
1.76
1.7
1.7
2.83
6.83
u/ml
1.39
14
54
11
48
2.32
1.71
1.0
1.1
—
—
—
0
0
0
48
0.00
1.70
0.0
1.4
—
—
—
0
0
20
114
1.78
1.58
1.5
1.4
264.73
325.38
ug/g
0.71
11
62
165
1409
1.25
1.55
1.4
1.3
0.55
2.18
u/ml
2.55
35
392
13
65
2.03
1.50
1.2
1.2
—
—
—
0
0
158
1350
1.24
1.47
5.1
3.4
0.00
0.01
estimate
1.23
35
514
96
1177
0.78
1.47
2.1
2.2
—
—
—
0
0
7
28
2.52
1.45
1.7
1.1
—
—
—
0
0
5
16
3.14
1.44
1.0
2.9
150.80
185.00
u/l
—
5
16
91
1119
0.77
1.42
3.5
2.7
0.24
0.32
e6/l
0.27
68
772
7
29
2.43
1.39
1.9
1.9
—
881935.71
—
0
7
41
290
1.45
1.39
3.7
2.3
70.07
76.96
ml/min/173m2
0.56
14
112
6
23
2.63
1.37
1.2
1.2
—
—
—
0
0
8
36
2.24
1.24
1.1
2.1
—
—
—
0
0
392
3706
1.22
1.22
3.9
3.8
—
—
—
0
0
5
19
2.65
1.22
1.6
1.3
348.88
81.04
nmol/l
—
5
13
0
33
0.00
1.16
0.0
1.6
—
—
—
0
0
516
5063
1.64
1.14
28.0
18.5
267.58
259.86
e9/l
1.41
516
4996
516
5063
1.64
1.14
27.9
18.5
89.77
90.23
fl
1.58
516
5029
7
30
2.35
1.12
1.0
1.0
—
—
—
0
0
61
480
1.31
1.12
5.0
3.9
17.40
22.24
%
1.81
18
201
25
362
0.68
1.12
3.0
2.8
—
—
—
0
0
11
59
1.88
1.08
1.5
1.3
0.43
0.47
nmol/l
0.32
11
54
16
97
1.67
1.08
2.1
2.3
—
—
—
0
0
26
178
1.48
1.07
1.8
2.8
0.69
0.61
%
0.65
26
178
13
75
1.75
1.03
1.0
1.1
119.23
116.96
%
0.10
13
70
7
34
2.07
1.03
1.1
1.1
12.57
6.82
mm/h
—
7
34
14
225
0.61
1.01
2.2
3.5
5.49
5.10
kpa
1.35
14
217
9
157
0.57
1.00
1.8
1.5
—
—
—
0
0
453
4374
1.24
0.99
4.5
4.2
4.71
4.71
mmol/l
0.03
445
4171
60
484
1.27
0.94
2.9
2.7
9.20
6.88
umol/l
0.31
48
411
15
232
0.64
0.94
1.5
1.8
2.76
3.22
mg/l
—
10
152
20
290
0.68
0.92
1.8
2.4
31.34
40.13
u/ml
0.22
20
276
14
86
1.64
0.91
1.4
1.3
—
—
—
0
0
12
71
1.71
0.89
1.6
1.1
—
—
—
0
0
8
42
1.92
0.89
1.1
1.9
—
—
—
0
0
64
528
1.24
0.84
2.4
2.2
20.22
24.36
%
1.93
58
494
0
24
0.00
0.79
0.0
1.4
—
—
—
0
0
58
699
0.81
0.79
1.6
1.8
3.62
3.36
ratio
0.65
37
520
8
48
1.68
0.79
1.1
1.4
—
—
—
0
0
0
26
0.00
0.78
0.0
1.7
—
—
—
0
0
9
54
1.68
0.75
1.4
1.8
—
—
—
0
0
18
125
1.46
0.73
1.1
1.0
2.92
3.90
u/ml
0.22
12
59
7
41
1.72
0.70
1.0
1.3
2.54
1.33
nmol/l
—
7
36
32
249
1.30
0.69
1.8
1.5
—
—
—
0
0
15
102
1.48
0.68
1.2
1.3
—
—
—
0
0
57
673
0.83
0.65
3.2
2.5
0.46
0.77
e6/l
1.96
35
335
452
4406
1.17
0.63
5.1
4.6
2.77
2.80
mmol/l
0.43
443
4191
8
51
1.58
0.60
1.5
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.9
—
—
—
0
0
14
97
1.46
0.59
5.6
2.3
9.86
10.55
g/l
0.25
14
91
133
1209
1.13
0.59
1.6
1.4
2.05
2.12
g/l
0.27
103
777
6
35
1.72
0.58
1.2
1.6
—
—
—
0
0
27
213
1.28
0.55
1.4
1.7
—
—
—
0
0
13
92
1.42
0.51
1.2
1.2
1.33
1.83
u/ml
—
6
36
10
67
1.50
0.50
1.5
1.5
—
—
—
0
0
18
136
1.33
0.49
1.2
1.3
—
—
—
0
0
109
991
1.13
0.49
3.5
2.6
303.11
319.35
umol/l
1.17
99
895
29
349
0.82
0.43
2.9
2.7
0.58
0.71
ug/l
0.33
13
200
445
4363
1.12
0.42
4.4
4.1
1.46
1.49
mmol/l
0.73
433
4138
18
140
1.30
0.42
1.2
1.1
1.03
1.63
u/ml
0.35
12
72
20
158
1.28
0.42
1.2
1.1
1.31
3.17
u/ml
1.10
14
81
8
57
1.41
0.42
1.1
1.2
18.38
17.57
u/l
—
8
48
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
29.17
—
0
15
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
17
216
0.78
0.41
1.8
1.4
—
—
—
0
0
7
105
0.66
0.39
2.0
1.3
—
—
—
0
0
9
67
1.35
0.38
1.2
1.1
—
—
—
0
0
9
70
1.29
0.37
2.3
1.9
—
—
—
0
0
13
168
0.77
0.36
7.7
9.3
24.80
24.40
mmol/l
0.11
13
163
17
211
0.80
0.35
1.3
1.2
—
—
—
0
0
6
44
1.37
0.34
1.8
1.2
—
—
—
0
0
6
44
1.37
0.34
2.2
1.6
0.55
0.47
e9/l
—
6
44
6
45
1.34
0.34
1.8
1.2
—
—
—
0
0
19
155
1.23
0.33
1.3
1.3
—
6.85
—
0
24
93
861
1.10
0.32
2.3
3.1
326.13
932.75
ng/l
7.04
83
697
14
111
1.27
0.30
5.6
2.3
6.45
7.23
g/l
2.19
14
106
14
111
1.27
0.30
5.6
2.3
3.01
3.53
g/l
1.05
14
106
8
62
1.29
0.28
1.4
1.6
30.01
37.12
nmol/l
—
8
56
415
4085
1.07
0.25
3.6
3.6
1.26
1.21
mmol/l
0.84
400
3857
22
255
0.86
0.25
2.0
1.6
0.23
0.28
mg/l
—
7
105
15
179
0.83
0.23
1.9
1.8
—
—
—
0
0
16
134
1.20
0.23
1.0
1.2
—
—
—
0
0
17
200
0.85
0.23
1.4
1.4
—
—
—
0
0
11
88
1.26
0.22
1.0
1.1
—
—
—
0
0
16
135
1.19
0.21
1.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
7.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
71
667
1.07
0.19
1.5
1.7
1.35
1.35
%
0.01
61
612
10
81
1.24
0.19
1.8
1.6
—
—
—
0
0
10
82
1.22
0.17
1.3
2.2
—
—
—
0
0
12
101
1.19
0.16
1.8
1.4
—
—
—
0
0
13
111
1.18
0.16
5.9
2.3
4.19
4.33
g/l
0.32
13
106
15
130
1.16
0.16
2.9
3.3
147.57
174.75
%
0.92
15
125
9
82
1.10
0.15
1.4
2.3
5.60
7.09
pmol/l
—
9
82
11
93
1.19
0.14
1.8
1.4
828.36
323.24
mu/l
0.44
11
79
8
98
0.81
0.14
2.1
2.2
121.88
129.78
g/l
—
8
81
12
104
1.16
0.12
6.3
2.3
2.13
2.93
g/l
1.85
12
99
51
538
0.94
0.12
1.4
1.7
3.55
3.41
mmol/l
0.35
29
362
33
352
0.93
0.11
1.2
1.0
—
—
—
0
0
5
60
0.83
0.08
1.2
1.5
—
1960.31
—
0
8
5
60
0.83
0.08
1.2
1.1
87.20
92.09
%
—
5
54
32
306
1.05
0.06
1.2
1.3
113.31
263.48
miu/ml
2.18
14
156
26
249
1.05
0.04
1.0
1.1
1.49
1.56
g/l
0.71
26
249
19
182
1.05
0.02
1.5
1.3
—
—
—
0
0
34
333
1.02
0.01
1.2
1.4
—
—
—
0
0
12
122
0.98
0.00
1.1
1.3
315.14
219.61
u/ml
—
7
74
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
0.50
—
0
6
0
8
0.00
-0.00
0.0
1.4
—
1.20
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.1
—
—
—
0
0
25
250
1.00
-0.00
1.0
1.2
0.87
0.88
g/l
0.08
25
250
0
8
0.00
-0.00
0.0
2.0
—
41.99
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
3.07
—
0
5
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_BINODISTOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BINODISTOTH | 1.046 [0.84, 1.31] | 0.695 |
| Birth year | 0.997 [0.99, 1.01] | 0.575 |
During the follow-up period (1.1.1998 — 31.12.2019), 105 out of 2492 females with H7_BINODISTOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BINODISTOTH | 1.139 [0.89, 1.45] | 0.291 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 1296 males with H7_BINODISTOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_BINODISTOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.227% |
| 5 | 0.569% | 1.355% |
| 10 | 1.518% | 3.457% |
| 15 | 3.118% | 6.739% |
| 20 | 5.849% | 11.563% |
Relationships between endpoints
↥Index endpoint: H7_BINODISTOTH – Other disorders of binocular vision
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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