Myasthenia gravis: Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
682 |
4. Check minimum number of eventsNone |
682 |
5. Include endpointsNone |
682 |
6. Filter based on genotype QC (FinnGen only) |
618 |
Control definitions (FinnGen only)
- Control exclude
- G6_MYONEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G70
Similar endpoints
↥List of similar endpoints to
Myasthenia gravis
based on the number of shared cases.
Similar with more cases:
- Diseases of the myoneural junction and muscle
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Neurological diseases
- Neurological diseases, wide definition
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3518 | 1791 | 1681 |
| Only index persons | 2942 | 1550 | 1392 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 56.01 | 50.07 | 62.40 |
| Only index persons | 54.55 | 48.24 | 61.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 618 | 323 | 295 |
| Unadjusted period prevalence (%) | 0.12 | 0.11 | 0.14 |
| Median age at first event (years) | 56.52 | 49.01 | 64.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 645
- Matched controls
- 6450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L04AX01
ATC
azathioprine; systemic
30.7
313.4
227
112
N07AA02
ATC
pyridostigmine; systemic
9233.7
307.7
527
*
108
Kela drug reimbursment
Myasthenia gravis
+∞
307.7
466
*
G70.0
ICD-10 Finland
Myasthenia gravis
+∞
307.7
597
*
H02.4
ICD-10 Finland
Ptosis of eyelid
23.6
210.1
163
91
H53.2
ICD-10 Finland
Diplopia
21.6
203.6
165
101
GEC24
NOMESCO Finland
Thoracoscopic thymectomy
1207.3
107.6
102
*
N07AA03
ATC
distigmine; systemic
208.7
88.7
90
5
G70.9
ICD-10 Finland
Myoneural disorder, unspecified
+∞
85.3
80
*
A12BA01
ATC
potassium chloride; oral
10.1
81.9
100
115
N99
ICPC
Neurological disease other
23.0
68.9
51
24
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.8
66.7
141
295
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
6.7
64.3
113
197
R03CA02
ATC
ephedrine; oral
168.1
59.0
61
*
3580A
ICD-9 Finland
Myoneural disorders, Myasthenia gravis
+∞
58.2
55
*
GD1AD
NOMESCO Finland
Thorax CT examination
5.5
53.2
117
251
G70
ICD-10 Finland
Myasthenia gravis and other myoneural disorders
+∞
49.6
47
*
73300
ICD-8 Finland
Other diseases of muscle, tendon and fascia, Myasthenia gravis
+∞
49.6
47
*
H02AB06
ATC
prednisolone; systemic
3.4
48.3
428
2360
R4130
NOMESCO Finland
Speech therapy
8.6
43.7
58
73
R13
ICD-10 Finland
Dysphagia
4.7
42.6
111
273
GEC23
NOMESCO Finland
Transsternal thymectomy
+∞
34.7
33
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.1
34.5
187
748
G35
ICD-10 Finland
Multiple sclerosis
12.4
32.7
33
28
5872
FHL
Thymic exploration or thymectomy
+∞
31.5
30
*
H02AB07
ATC
prednisone; oral
3.3
30.7
141
509
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
28.6
402
2538
R47.1
ICD-10 Finland
Dysarthria and anarthria
10.5
27.6
31
31
G72.9
ICD-10 Finland
Myopathy, unspecified
282.3
26.9
27
*
ZXC96
NOMESCO Finland
Robot assisted procedure
5.6
24.6
48
91
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.4
24.1
94
304
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
24.1
283
1613
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.8
22.0
71
202
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.1
21.7
101
363
N28
ICPC
Limited function/disability (N)
7.0
20.1
31
46
G70.8
ICD-10 Finland
Other specified myoneural disorders
+∞
19.9
19
*
G70.28
ICD-10 Finland
Other congenital and developmental myasthenia
+∞
19.9
19
*
2AB04, ,
NOMESCO Finland
108.4
19.7
21
*
WW400
NOMESCO Finland
Plasmaferesis
206.1
19.7
20
*
L04AA06
ATC
mycophenolic acid; systemic
6.4
19.1
32
52
G70.20
ICD-10 Finland
Congenital and developmental myasthenia
+∞
18.8
18
*
GEC26
NOMESCO Finland
Mediastinoscopic thymectomy
+∞
17.8
17
*
AA1AD
NOMESCO Finland
CT of head and brain
2.1
17.8
239
1399
N29
ICPC
Neurological sympt/complt other
6.6
17.7
29
46
H50.2
ICD-10 Finland
Vertical strabismus
16.5
17.1
27
17
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.6
14.3
94
403
R06.0
ICD-10 Finland
Dyspnoea
1.9
13.1
212
1300
XKD03
NOMESCO Finland
Urethral pressure profilometry
5.2
13.0
27
54
G70.1
ICD-10 Finland
Toxic myoneural disorders
+∞
12.5
12
*
R4110
NOMESCO Finland
Physiotherapy
1.9
12.2
203
1252
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
18.5
12.1
18
10
XKC03
NOMESCO Finland
Water cystometry
4.2
11.8
32
80
A02BC02
ATC
pantoprazole; systemic
1.9
11.6
467
3747
G70.21
ICD-10 Finland
Limb girdle myasthenia
+∞
11.5
11
*
WX882
NOMESCO Finland
High dependency care
4.4
11.4
29
69
D38.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thymus
44.1
11.0
13
*
L28
ICPC
Limited function/disability (L)
2.0
10.6
141
801
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.0
10.5
30
78
D15.0
ICD-10 Finland
Benign neoplasm: Thymus
+∞
10.4
10
*
XA100
NOMESCO Finland
Tensilon test
+∞
10.4
10
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
10.3
135
762
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
10.2
141
810
TAB00
NOMESCO Finland
Lumbar puncture
3.1
10.2
43
145
XCK00
NOMESCO Finland
Perimetry
2.8
10.1
52
196
ZX120
NOMESCO Finland
Intravenous
2.4
10.0
76
346
R03DA04
ATC
theophylline; systemic, rectal
3.0
10.0
46
163
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
9.8
101
522
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
15.3
9.5
15
10
73308, ,
ICD-8 Finland
+∞
9.4
9
*
G73.1*C80.99
ICD-10 Finland
Eaton-Lambert syndrome
+∞
9.4
9
*
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
9.3
90
453
WX725
NOMESCO Finland
Noninvasive ventilation
2.7
9.0
51
202
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.3
8.6
70
329
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
9.2
8.6
17
19
D38.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Mediastinum
27.9
8.5
11
*
N03AX16
ATC
[U] pregabalin
1.8
8.5
157
985
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
8.5
248
1764
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
8.4
111
626
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
9.6
8.3
16
17
6BA02, ,
NOMESCO Finland
33.8
8.1
10
*
G72.8
ICD-10 Finland
Other specified myopathies
33.8
8.1
10
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
9.1
8.1
16
18
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
8.0
279
2067
H03AA01
ATC
levothyroxine sodium; systemic
1.8
7.9
151
956
WX892
NOMESCO Finland
Monitored bed care
2.4
7.8
57
255
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.8
7.8
39
145
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
6.5
7.8
19
30
R5140
NOMESCO Finland
Monitoring the use of the aid
2.0
7.7
88
471
B03BA03
ATC
hydroxocobalamin; parenteral
2.6
7.7
45
182
R02
ICPC
Shortness of breath/dyspnoea
1.9
7.6
98
547
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.5
7.6
48
201
NXL00
NOMESCO Finland
Biopsy of muscle
25.3
7.6
10
*
M05BA04
ATC
alendronic acid; oral
2.3
7.5
61
286
R32
ICD-10 Finland
Unspecified urinary incontinence
3.6
7.5
24
68
L19
ICPC
Muscle symptom/complaint NOS
3.5
7.5
25
73
104
Kela drug reimbursment
Thyroid insufficiency
2.4
7.5
51
222
G47.3
ICD-10 Finland
Sleep apnoea
1.7
7.4
161
1052
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
7.3
130
803
G71.9
ICD-10 Finland
Primary disorder of muscle, unspecified
+∞
7.3
7
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.4
7.2
16
22
CS494
NOMESCO Finland
Other visual field testing
3.5
7.2
24
70
CE2W4
NOMESCO Finland
Eye movement mapping
20.3
7.1
10
5
G51.0
ICD-10 Finland
Bell palsy
3.6
6.9
22
62
XA402
NOMESCO Finland
ENMG
3.5
6.9
23
67
Z3226
NOMESCO Finland
Physiotherapist
1.8
6.9
122
752
XG466
NOMESCO Finland
Sleep oxymetry
3.0
6.8
29
99
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.3
6.8
53
245
J96.1
ICD-10 Finland
Chronic respiratory failure
3.6
6.8
22
63
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
6.5
6.7
16
25
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.8
6.6
32
117
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.0
6.6
78
423
R53
ICD-10 Finland
Malaise and fatigue
1.6
6.6
165
1117
H53.1
ICD-10 Finland
Subjective visual disturbances
2.2
6.5
53
249
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
70.5
6.4
7
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.9
6.3
87
496
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
6.3
229
1689
D21
ICPC
Swallowing problem
3.9
6.3
18
47
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.8
6.3
31
115
8580/3-C37.9
ICD-O-3
Thymoma, NOS, of thymus
+∞
6.3
6
*
G71.3
ICD-10 Finland
Mitochondrial myopathy, not elsewhere classified
+∞
6.3
6
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.2
6.2
54
261
PA7BD
NOMESCO Finland
CT angiography of neck and brain
4.0
6.2
17
43
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
5.4
6.2
17
32
J01DB01
ATC
cefalexin; oral
1.7
6.2
519
4591
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
3.5
6.1
20
58
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
276
42
114.12
307.65
1.4
1.1
12.96
0.10
nmol/l
—
182
5
376
1842
3.50
53.38
3.1
2.1
158.94
169.96
u/l
0.20
368
1752
59
60
10.72
52.34
1.1
1.1
—
—
—
0
0
150
476
3.80
40.70
2.8
2.6
9.55
10.98
g/l
3.30
144
440
427
2711
2.70
31.11
7.8
6.8
1.21
1.21
mmol/l
0.13
413
2499
454
3012
2.71
29.55
8.6
7.6
1.21
1.21
mmol/l
0.02
409
2612
481
3352
2.71
27.14
17.2
9.9
4.30
4.12
e9/l
1.19
438
2920
212
1042
2.54
25.32
3.2
3.4
0.80
0.82
mmol/l
1.19
204
991
31
39
8.30
23.19
3.5
1.8
375.96
738.80
e6/l
0.79
25
30
226
1194
2.37
22.60
1.7
1.5
2.08
2.52
g/l
3.30
167
737
33
49
7.04
21.42
1.2
1.1
—
—
—
0
0
476
3480
2.40
21.24
7.1
5.1
6.51
6.72
mmol/l
1.98
468
3307
35
59
6.22
20.16
1.2
1.1
—
—
—
0
0
103
391
2.94
20.03
2.5
2.5
18.00
17.73
au/ml
—
5
34
33
56
6.16
18.87
1.2
1.1
—
—
—
0
0
154
741
2.42
18.54
8.2
7.8
1.44
1.00
mmol/l
0.66
133
614
131
589
2.54
18.24
2.0
2.1
345.63
383.44
nmol/l
1.46
125
558
62
186
3.58
17.71
1.5
1.5
0.96
0.04
iu/ml
—
7
34
24
31
8.00
17.52
1.1
1.0
0.95
1.13
u/l
—
10
17
153
751
2.36
17.51
8.5
7.8
12.12
12.09
kpa
0.02
147
730
153
751
2.36
17.51
8.5
7.8
5.34
5.12
kpa
1.71
146
728
27
22
12.76
15.48
1.1
1.0
1891.89
1500.95
miu/ml
0.76
27
22
70
253
2.98
14.73
2.1
2.0
23.07
7.88
iu/ml
1.05
14
63
46
129
3.76
14.48
1.5
1.3
3.97
60.62
e6/l
0.71
37
93
46
131
3.70
14.16
1.7
1.3
127.68
1066.09
e6/l
0.52
37
97
83
337
2.68
14.05
4.6
4.0
1.47
1.79
mmol/l
0.33
77
251
368
2669
1.88
13.63
4.9
5.3
34.56
35.52
g/l
2.64
353
2506
234
1478
1.92
13.25
5.0
4.2
92.61
89.01
%
1.60
228
1453
91
404
2.46
12.79
4.9
3.9
5.28
5.13
kpa
0.91
91
389
527
4361
2.14
12.63
5.1
4.3
15.06
14.83
pmol/l
1.30
509
3969
94
427
2.41
12.55
1.7
1.6
—
—
—
0
0
21
34
6.35
12.54
3.3
2.0
—
—
—
0
0
50
164
3.22
12.39
1.2
1.2
—
—
—
0
0
25
28
9.24
12.34
1.1
1.0
—
—
—
0
0
114
571
2.21
12.10
8.3
7.6
1.44
1.32
mmol/l
0.29
109
560
18
11
16.78
11.72
1.2
1.0
—
—
—
0
0
376
2831
1.79
11.49
12.9
14.5
1.18
1.25
inr
1.92
309
2342
513
4271
1.98
11.09
5.5
4.5
12.42
12.32
mm/h
0.05
493
3978
89
417
2.32
11.04
10.3
9.6
1.23
1.33
%
0.44
89
412
54
199
2.87
10.96
1.9
1.5
0.21
0.23
g/l
1.29
54
190
50
181
2.91
10.48
1.3
1.2
3.34
8.05
u/ml
—
5
32
172
1053
1.86
10.30
2.2
1.9
—
—
—
0
0
23
31
7.65
10.26
1.1
1.3
5.38
6.52
u/l
0.31
18
26
355
2695
1.71
9.93
2.5
2.2
92.55
95.47
pmol/l
0.60
213
1403
46
167
2.89
9.60
1.2
1.3
—
—
—
0
0
463
3813
1.76
9.32
7.3
4.8
1371.60
1315.18
e6/l
—
10
66
44
159
2.90
9.26
3.6
3.3
1.77
1.92
index
0.07
22
91
40
137
3.05
9.24
1.3
1.2
65.90
61.27
u/ml
—
7
18
217
1471
1.72
9.01
2.8
2.4
—
—
—
0
0
520
4453
1.87
8.92
9.9
8.6
76.40
79.39
u/l
0.81
505
4212
42
154
2.85
8.62
1.1
1.2
—
7.83
—
0
12
385
3056
1.64
8.50
5.1
4.0
0.00
0.00
estimate
0.50
71
635
274
2000
1.64
8.46
4.8
3.4
42.01
89.57
e6/l
0.70
220
1545
136
820
1.83
8.38
4.3
6.2
1.02
1.02
mmol/l
0.04
128
757
390
3115
1.64
8.32
5.3
4.0
0.00
0.51
estimate
0.52
67
603
577
5154
2.13
8.22
7.0
5.3
1.90
1.94
mu/l
0.28
560
4718
386
3088
1.62
8.07
5.2
4.0
41.07
5.35
estimate
0.64
74
654
49
204
2.52
7.87
1.8
1.8
—
—
—
0
0
259
1906
1.60
7.50
3.4
3.3
1336.29
1298.50
ng/l
0.06
219
1641
73
378
2.05
7.01
1.9
1.7
—
—
—
0
0
248
1838
1.57
6.81
1.9
1.7
19.14
20.65
nmol/l
1.05
221
1539
221
1596
1.59
6.78
2.6
2.2
3.00
2.91
mg/l
0.23
190
1366
171
1162
1.64
6.73
5.0
4.0
68.67
297.77
ng/l
3.31
139
919
198
1399
1.60
6.64
3.5
2.7
4.61
5.66
e6/l
0.48
186
1277
276
2114
1.53
6.44
3.2
3.7
2.32
2.35
mmol/l
4.19
251
1920
296
2313
1.52
6.23
5.2
4.0
28.49
38.16
ng/l
1.81
236
1736
187
1325
1.58
6.12
1.8
1.7
1.42
1.27
mg/l
0.30
149
1032
325
2601
1.50
6.04
2.7
2.5
74.94
77.24
nmol/l
0.82
301
2313
383
3171
1.51
6.03
6.7
6.9
11.47
11.56
umol/l
0.03
377
3028
48
224
2.23
6.01
1.9
1.9
—
—
—
0
0
231
1726
1.53
5.93
4.7
3.2
0.45
0.45
e6/l
0.00
176
1267
124
801
1.68
5.87
2.2
1.8
—
—
—
0
0
101
619
1.75
5.78
3.7
3.6
2.61
1.96
mmol/l
1.03
92
533
256
1965
1.50
5.74
3.6
3.3
30.18
31.85
u/l
0.39
247
1853
92
558
1.76
5.46
2.4
2.4
45.88
33.42
u/l
0.84
83
466
20
63
3.24
5.36
1.6
1.2
0.19
0.19
nmol/l
0.06
14
45
603
5648
2.04
4.90
30.5
20.1
139.82
139.67
mmol/l
0.91
597
5553
141
981
1.56
4.88
4.4
3.0
5.39
1.83
e6/l
1.70
76
485
154
1097
1.53
4.79
1.3
1.3
33.41
32.42
iu/ml
0.03
29
340
19
63
3.08
4.70
1.1
1.2
—
79.00
—
0
6
27
109
2.54
4.68
1.6
1.3
—
—
—
0
0
27
109
2.54
4.68
1.6
1.3
—
—
—
0
0
40
193
2.14
4.66
1.4
1.2
—
—
—
0
0
576
5341
1.73
4.52
23.7
16.2
81.00
79.33
ml/min/173m2
1.22
545
4966
13
27
4.89
4.51
1.1
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
13
27
4.89
4.51
1.1
1.2
—
—
—
0
0
38
183
2.14
4.46
1.1
1.3
—
—
—
0
0
149
1071
1.51
4.41
4.3
2.9
1.02
1.04
e6/l
0.04
86
576
12
24
5.07
4.33
1.2
1.3
—
—
—
0
0
588
5496
1.79
4.32
25.9
16.8
21.37
24.98
mg/l
2.58
529
4551
10
16
6.33
4.30
1.1
1.1
—
—
—
0
0
10
16
6.33
4.30
1.1
1.2
—
—
—
0
0
143
1024
1.51
4.30
1.8
1.7
1006.60
1201.93
nmol/l
1.95
114
777
111
754
1.57
4.24
2.3
1.9
—
—
—
0
0
12
25
4.87
4.20
1.3
1.3
—
—
—
0
0
10
17
5.96
4.14
1.1
1.2
—
—
—
0
0
424
3715
1.41
4.12
4.2
3.4
52.50
51.20
u/l
0.09
403
3494
12
26
4.68
4.07
3.2
3.0
588.33
917.69
u/ml
1.03
12
26
329
2766
1.39
4.06
3.7
2.8
—
—
estimate
—
0
0
38
191
2.05
4.01
1.4
1.4
300.24
283.18
ug/g
0.20
25
117
18
64
2.86
3.98
2.5
2.9
3.45
6.12
nmol/l
0.50
18
64
136
979
1.49
3.97
2.5
2.6
2.35
2.30
g/l
0.40
129
913
33
160
2.12
3.83
2.1
1.9
4.21
3.77
iu/l
—
10
63
324
2734
1.37
3.83
3.7
3.1
147.85
134.34
ug/l
0.30
309
2539
237
1905
1.39
3.77
2.9
2.5
59.14
104.62
u/l
0.55
225
1765
19
74
2.62
3.58
1.2
1.3
510.93
328.81
pmol/l
0.46
14
64
218
1744
1.38
3.52
5.6
4.1
0.00
0.01
estimate
0.96
60
593
9
17
5.35
3.52
1.0
1.1
—
—
—
0
0
9
17
5.35
3.52
1.0
1.1
—
—
—
0
0
56
337
1.72
3.45
2.7
3.8
4.21
4.59
pmol/l
1.59
46
305
50
293
1.77
3.38
1.8
1.9
1.49
1.50
g/l
0.03
43
261
15
53
2.87
3.37
1.3
1.2
—
—
—
0
0
8
14
5.77
3.35
1.1
1.3
—
—
—
0
0
6
7
8.64
3.27
1.2
1.6
—
—
—
0
0
124
911
1.45
3.24
2.6
2.7
22.23
22.68
%
0.12
119
856
15
55
2.77
3.17
1.3
1.2
—
—
—
0
0
15
55
2.77
3.17
1.3
1.2
—
—
—
0
0
16
61
2.66
3.15
1.3
1.1
—
—
—
0
0
61
386
1.64
3.13
1.2
1.3
151.54
141.70
u/ml
0.05
19
150
6
8
7.56
3.06
1.2
1.4
—
—
—
0
0
99
706
1.48
3.01
2.9
2.8
13.81
8.13
umol/l
0.72
85
627
139
1057
1.40
2.99
2.6
2.6
12.24
13.09
umol/l
0.67
131
993
100
718
1.46
2.94
1.8
2.4
172.19
132.90
ug/g
0.31
79
570
16
64
2.54
2.89
1.2
1.3
—
—
—
0
0
7
13
5.43
2.87
1.1
1.2
—
—
—
0
0
17
71
2.43
2.82
1.2
2.0
—
—
—
0
0
16
65
2.50
2.81
1.2
2.1
—
—
—
0
0
603
5773
1.68
2.76
21.8
12.7
26.96
25.51
u/l
1.14
595
5605
19
85
2.27
2.73
1.1
1.2
1.33
1.56
u/ml
—
6
27
14
54
2.63
2.72
1.3
1.2
—
—
—
0
0
166
1322
1.34
2.66
1.3
1.3
0.65
1.67
u/ml
2.11
31
369
31
170
1.87
2.63
1.5
1.4
—
—
—
0
0
14
55
2.58
2.63
4.4
3.2
10.63
12.11
index
—
8
36
8
20
4.04
2.57
1.0
1.1
—
—
—
0
0
36
209
1.77
2.56
2.3
3.7
1.39
2.90
ratio
1.58
13
125
48
302
1.64
2.56
1.5
1.4
—
—
—
0
0
5
7
7.19
2.55
1.0
1.1
—
—
—
0
0
5
7
7.19
2.55
1.2
1.4
1.85
1.75
umol/24h
—
5
7
6
11
5.49
2.55
1.0
1.1
—
—
—
0
0
27
143
1.93
2.54
2.0
1.8
2646.49
4897.06
u/l
—
8
46
66
449
1.52
2.53
3.5
3.3
140.98
193.56
ng/l
1.08
58
411
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
34
195
1.78
2.52
2.2
3.1
0.36
0.38
iu/ml
0.22
18
109
362
3221
1.28
2.50
3.2
2.9
—
—
—
0
0
11
39
2.85
2.35
1.4
1.4
11.82
12.53
u/l
0.20
11
34
15
66
2.30
2.26
1.3
1.2
—
—
—
0
0
128
1006
1.34
2.23
1.3
1.3
21.26
12.58
u/ml
0.38
37
374
15
68
2.23
2.12
4.6
3.7
67.53
54.50
%
1.65
15
62
66
468
1.46
2.10
1.5
1.5
—
—
—
0
0
11
43
2.58
2.09
1.1
1.3
—
—
—
0
0
154
1259
1.29
2.02
2.4
3.1
2.44
2.45
mmol/l
0.96
136
1143
11
44
2.53
2.02
1.1
1.3
—
—
—
0
0
8
26
3.10
2.02
1.1
1.1
—
—
—
0
0
10
38
2.66
2.01
1.4
1.8
—
—
—
0
0
40
258
1.59
1.97
1.6
1.6
0.27
0.33
mg/l
0.33
12
120
17
84
2.05
1.97
1.2
1.4
—
—
—
0
0
17
84
2.05
1.97
1.2
1.4
—
—
—
0
0
5
11
4.57
1.94
1.2
1.4
—
—
—
0
0
6
16
3.77
1.94
1.2
1.2
—
—
—
0
0
16
78
2.08
1.92
1.0
1.1
—
—
—
0
0
17
85
2.03
1.91
1.2
1.4
—
—
—
0
0
187
1576
1.26
1.91
2.6
2.9
335.30
347.11
umol/l
0.89
171
1385
14
65
2.18
1.89
1.6
1.3
—
—
—
0
0
9
34
2.67
1.87
1.3
1.1
—
—
—
0
0
17
87
1.98
1.81
1.2
1.3
—
—
—
0
0
17
87
1.98
1.81
1.1
1.1
1.67
5.92
u/ml
—
6
38
67
491
1.41
1.81
1.8
2.8
76.04
66.02
ml/min/173m2
1.25
28
210
6
18
3.35
1.75
1.8
1.1
—
—
—
0
0
244
2138
1.23
1.73
3.2
3.4
8.04
7.67
mmol/l
0.67
215
1778
13
61
2.15
1.72
1.5
1.3
25740.00
57332.34
e6/l
—
8
41
17
89
1.93
1.71
1.2
1.3
—
—
—
0
0
17
89
1.93
1.71
1.2
1.3
—
—
—
0
0
26
159
1.66
1.61
1.3
1.6
—
—
—
0
0
24
385
0.61
1.61
1.5
1.8
3.64
3.46
mmol/l
0.33
16
288
8
32
2.52
1.60
1.0
1.1
—
—
—
0
0
8
32
2.52
1.60
1.1
1.9
—
—
—
0
0
8
32
2.52
1.60
1.1
1.9
—
—
—
0
0
8
32
2.52
1.60
1.1
1.9
—
—
—
0
0
8
32
2.52
1.60
1.1
1.9
—
—
—
0
0
262
2331
1.21
1.57
5.5
3.9
0.00
0.03
estimate
2.11
62
529
235
2074
1.21
1.52
3.6
4.2
7.82
8.85
mg/mmol
0.11
151
1293
6
21
2.87
1.51
1.0
1.1
—
—
—
0
0
26
163
1.62
1.48
1.7
1.6
7779.11
14631.11
e6/l
0.86
19
123
10
46
2.19
1.40
1.4
1.2
—
—
—
0
0
6
23
2.62
1.37
1.0
1.0
—
—
—
0
0
6
23
2.62
1.37
1.5
1.2
5.37
6.80
mmol/l
—
6
23
547
5261
1.26
1.32
7.0
6.8
39.51
39.56
mmol/mol
0.05
519
4921
6
24
2.51
1.30
1.2
2.1
—
—
—
0
0
6
24
2.51
1.30
1.2
2.1
—
—
—
0
0
63
485
1.33
1.30
3.8
4.2
92.94
88.43
ng/l
0.12
58
427
557
5374
1.27
1.27
5.8
5.4
5.93
6.00
mmol/l
0.85
525
4917
33
228
1.47
1.27
2.0
2.9
—
—
—
0
0
13
70
1.87
1.24
1.2
1.3
7.22
7.51
mmol/l
0.17
13
58
23
147
1.59
1.24
1.3
1.5
—
—
—
0
0
6
25
2.41
1.24
1.3
2.0
—
—
—
0
0
8
36
2.24
1.24
4.8
3.3
0.63
0.83
index
—
8
36
26
172
1.53
1.22
1.3
1.7
—
—
—
0
0
25
164
1.55
1.22
1.3
1.1
—
—
—
0
0
25
164
1.55
1.22
1.3
1.1
—
—
—
0
0
22
140
1.59
1.21
1.4
1.6
—
—
—
0
0
607
5932
1.39
1.19
43.2
25.7
255.94
246.06
e9/l
3.02
599
5823
6
26
2.32
1.19
1.2
2.0
40.55
41.96
g/l
—
6
26
11
57
1.95
1.17
1.1
1.8
—
—
—
0
0
11
57
1.95
1.17
1.1
1.8
—
—
—
0
0
11
57
1.95
1.17
1.1
1.8
—
—
—
0
0
159
1384
1.20
1.17
6.0
4.2
1.02
1.02
kg/l
0.11
124
935
607
5935
1.39
1.16
43.1
25.6
4.47
4.46
e12/l
0.18
599
5806
8
40
2.01
1.12
1.4
1.6
—
—
—
0
0
145
1257
1.20
1.11
1.8
1.8
418.20
11261259.52
pmol/l
0.50
128
1039
22
145
1.54
1.07
1.5
1.3
—
—
—
0
0
66
528
1.28
1.06
3.2
2.5
4.39
6.77
ug/l
1.29
55
480
7
33
2.13
1.06
1.7
1.7
—
—
—
0
0
7
33
2.13
1.06
1.4
1.7
—
—
—
0
0
7
33
2.13
1.06
1.7
1.7
—
—
—
0
0
5
22
2.28
1.03
1.4
1.6
7.40
7.74
mmol/l
—
5
22
92
769
1.23
1.03
4.6
5.0
30.17
31.84
%
0.94
69
492
10
53
1.90
1.01
1.1
1.4
—
—
—
0
0
19
123
1.56
1.00
1.3
1.5
—
—
—
0
0
17
107
1.60
1.00
1.4
1.9
—
—
—
0
0
7
35
2.01
1.00
1.4
1.7
—
—
—
0
0
9
49
1.85
0.99
1.3
1.2
13.22
11.26
u/l
—
9
43
7
36
1.95
0.97
1.0
1.2
—
—
—
0
0
7
36
1.95
0.97
1.3
1.2
—
—
—
0
0
7
36
1.95
0.97
1.0
1.2
—
—
—
0
0
39
510
0.75
0.97
1.7
2.1
3.54
3.48
ratio
0.12
34
411
13
77
1.70
0.95
1.4
1.6
—
—
—
0
0
6
27
2.23
0.93
2.0
1.6
44.12
59.87
ug/l
—
6
27
23
160
1.45
0.90
1.3
1.7
—
—
—
0
0
13
79
1.66
0.88
1.2
1.3
5.85
6.05
mmol/l
0.11
13
74
8
46
1.75
0.82
1.0
1.2
—
—
—
0
0
12
73
1.66
0.82
1.5
1.6
—
—
—
0
0
6
32
1.88
0.82
1.0
1.4
—
—
—
0
0
235
2167
1.13
0.80
5.2
5.9
2.93
2.55
ug/l
0.23
214
1946
6
33
1.83
0.79
1.0
2.2
91.83
104.00
%
—
6
33
261
2424
1.13
0.79
2.0
1.9
1.41
1.32
mmol/l
1.05
220
2010
26
191
1.38
0.78
2.3
1.6
—
—
—
0
0
10
59
1.71
0.76
1.0
1.3
—
—
—
0
0
18
124
1.46
0.75
3.3
4.1
32.32
27.46
mg/l
0.21
13
84
38
298
1.29
0.75
6.3
4.8
1.49
1.53
%
0.16
33
284
35
272
1.30
0.74
1.1
1.0
—
—
—
0
0
181
1649
1.14
0.74
4.6
3.5
0.00
0.06
estimate
0.63
58
504
10
60
1.68
0.72
1.0
1.6
—
—
—
0
0
9
145
0.62
0.70
1.4
1.4
—
—
—
0
0
12
77
1.57
0.69
1.2
1.1
1.42
1.79
eliau/ml
—
5
30
14
94
1.50
0.67
1.3
1.4
—
—
—
0
0
18
128
1.42
0.66
1.3
1.6
—
—
—
0
0
15
103
1.47
0.65
1.3
1.6
—
—
—
0
0
7
44
1.60
0.65
1.0
1.0
305.29
286.36
mg/l
—
7
39
22
164
1.35
0.63
2.1
1.5
—
—
—
0
0
16
114
1.41
0.59
1.5
1.9
3.88
4.79
mmol/24h
0.40
16
100
72
626
1.17
0.58
1.8
1.8
1.45
1.49
%
0.20
63
537
28
220
1.29
0.58
1.3
1.9
—
—
—
0
0
5
86
0.58
0.56
1.8
1.7
—
—
—
0
0
100
897
1.14
0.53
1.5
1.5
—
—
—
0
0
6
40
1.50
0.51
1.2
1.7
—
—
—
0
0
33
271
1.23
0.49
1.4
1.9
—
—
—
0
0
7
46
1.53
0.48
1.7
1.7
—
—
—
0
0
21
165
1.28
0.45
1.5
1.5
264.53
274.87
mu/l
0.12
21
152
186
1745
1.09
0.45
4.3
4.7
22.34
21.33
%
0.41
97
893
7
50
1.40
0.45
1.0
1.0
—
—
—
0
0
12
163
0.73
0.44
1.7
1.6
—
—
—
0
0
5
31
1.62
0.43
1.0
1.2
—
—
—
0
0
5
31
1.62
0.43
1.0
1.2
—
—
—
0
0
5
33
1.52
0.41
2.0
1.3
69.40
80.48
umol/l
—
5
33
5
33
1.52
0.41
1.6
1.3
—
—
—
0
0
9
68
1.33
0.37
3.2
3.9
—
—
—
0
0
71
783
0.90
0.36
1.6
1.5
—
—
—
0
0
5
77
0.65
0.36
2.4
2.8
106.40
105.30
mmol/l
—
5
77
18
145
1.25
0.34
1.2
1.3
215.40
258.07
miu/ml
—
5
62
6
46
1.31
0.33
1.5
1.1
97.83
105.24
pmol/l
—
6
46
69
628
1.11
0.32
4.2
3.3
—
—
—
0
0
20
165
1.22
0.31
1.3
1.3
—
—
—
0
0
31
268
1.16
0.31
1.3
1.3
—
—
—
0
0
5
74
0.67
0.26
2.4
2.9
1.20
1.19
mmol/l
—
5
74
9
74
1.22
0.25
1.2
1.6
—
—
—
0
0
5
41
1.22
0.22
1.2
1.7
12.66
13.59
umol/l
—
5
36
49
450
1.10
0.21
1.8
1.9
—
—
—
0
0
5
42
1.19
0.21
1.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
5
66
0.76
0.17
1.4
1.2
1.25
1.52
nmol/l
—
5
57
18
158
1.14
0.16
1.6
1.4
—
—
—
0
0
11
92
1.20
0.16
1.0
1.0
—
—
—
0
0
134
1294
1.04
0.15
3.0
3.3
0.64
0.76
ug/l
1.75
94
876
7
89
0.78
0.14
1.1
1.1
—
—
—
0
0
52
490
1.07
0.14
2.0
2.1
—
—
—
0
0
13
113
1.15
0.13
2.3
3.2
8.73
9.16
pmol/l
0.08
13
113
73
698
1.05
0.13
12.3
7.5
—
—
—
0
0
558
5548
1.04
0.11
6.1
6.1
2.70
2.66
mmol/l
0.58
521
5116
5
44
1.14
0.10
1.0
1.6
0.79
1.06
promille
—
5
36
13
117
1.11
0.08
2.8
4.0
153.27
475.96
u/ml
0.67
13
112
6
73
0.82
0.07
1.7
1.4
19.32
27.34
u/l
—
6
62
548
5458
1.03
0.06
5.4
5.4
4.63
4.57
mmol/l
0.73
519
5058
521
5188
1.02
0.06
4.5
4.5
1.36
1.28
mmol/l
2.16
489
4746
67
658
1.02
0.03
3.4
4.5
395.25
29.92
ug/l
0.48
56
554
20
209
0.96
0.03
1.5
1.8
4.11
3.77
mg/l
0.06
15
160
16
154
1.04
0.00
1.2
1.2
1.51
1.56
g/l
0.41
16
154
544
5434
1.01
0.00
5.3
5.2
1.43
1.46
mmol/l
0.83
511
5001
16
165
0.97
0.00
1.2
1.2
0.99
0.89
g/l
0.73
16
165
20
205
0.97
0.00
1.8
1.6
7.39
10.55
u/ml
—
7
38
16
164
0.97
0.00
1.2
1.4
—
—
—
0
0
6
65
0.92
0.00
2.2
2.5
—
—
—
0
0
6
65
0.92
0.00
1.5
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
0.00
2.2
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.6
1.5
53.89
51.46
ug/l
—
5
58
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
-0.00
1.2
2.6
54.58
5.10
umol/l
—
5
46
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
8.4
—
5.10
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_MYASTHENIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MYASTHENIA | 1.455 [1.19, 1.78] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.096 |
During the follow-up period (1.1.1998 — 31.12.2019), 200 out of 993 females with G6_MYASTHENIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MYASTHENIA | 1.196 [1.01, 1.42] | 0.04 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 1043 males with G6_MYASTHENIA died.
Mortality risk
Mortality risk for people of age
years, who have G6_MYASTHENIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.116% | 0.157% |
| 5 | 0.643% | 1.359% |
| 10 | 1.895% | 3.372% |
| 15 | 3.606% | 6.583% |
| 20 | 6.362% | 11.147% |
Relationships between endpoints
↥Index endpoint: G6_MYASTHENIA – Myasthenia gravis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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