Risteys · G6_MYASTHENIA

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ATC codes for adverse effects of Drugs — ANY Hospital discharge: ICD-10 — G70.0# 1 out of 7 registries used, show all original rules.	58
4. Check minimum number of events None	58
5. Include endpoints None	58
6. Filter based on genotype QC (FinnGen only)	51

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	51	36	15
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	42.51	37.91	53.53

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
56: Matched controls
560

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G70.0

ICD-10 Finland

Myasthenia gravis

+∞

80.2

108

Kela drug reimbursment

Myasthenia gravis

+∞

75.0

N07AA02

ATC

pyridostigmine; systemic

4107.1

69.6

N07AA03

ATC

distigmine; systemic

+∞

33.8

3580A

ICD-9 Finland

Myoneural disorders, Myasthenia gravis

+∞

26.1

R03CA02

ATC

ephedrine; oral

302.8

21.1

A12BA01

ATC

potassium chloride; oral

35.9

20.2

G70.9

ICD-10 Finland

Myoneural disorder, unspecified

+∞

20.0

L04AX01

ATC

azathioprine; systemic

38.9

17.7

73300

ICD-8 Finland

Other diseases of muscle, tendon and fascia, Myasthenia gravis

+∞

16.4

5872

FHL

Thymic exploration or thymectomy

+∞

16.4

G70

ICD-10 Finland

Myasthenia gravis and other myoneural disorders

+∞

11.9

GEC23

NOMESCO Finland

Transsternal thymectomy

+∞

9.6

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019060) Gas panel - Arterial blood

5.16

4.11

4.3

4.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

173

2.58

3.00

7.1

3.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.77

2.93

2.0

1.4

—

(3018418) pH of Serum or Plasma

159

2.52

2.86

6.1

4.0

7.40

0.01

114

(3018095) Leukocytes [#/volume] in Urine

195

2.32

2.42

9.6

3.7

108.28

55.66

e6/l

0.23

138

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

2.40

0.0

5.0

—

31.32

—

(3023368) Bacteria identified in Blood by Culture

130

2.31

2.27

3.7

4.1

—

(42870588) Differential panel, method unspecified - Blood

167

2.19

2.13

13.5

5.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

4.06

1.99

1.7

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.78

1.84

1.3

1.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

1.80

0.0

2.5

—

3.03

—

(3000991) Gas panel - Venous blood

2.61

1.69

7.0

8.8

—

(40758558) Short blood count panel - Blood

161

2.00

1.69

10.9

6.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.34

1.50

2.7

1.7

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

271

1.92

1.48

7.1

8.0

19.32

10.07

umol/l

0.54

256

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.93

1.48

1.7

1.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.93

1.48

2.7

2.4

104.33

100.36

—

(3020891) Body temperature

2.93

1.48

10.2

4.4

37.10

36.94

°c

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

3.32

1.47

5.0

2.9

2.62

3.90

g/l

—

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

0.00

1.40

0.0

2.2

—

3.27

—

(3010421) pH of Blood

3.12

1.39

5.0

3.9

7.42

7.43

—

(3009261) Glucose [Presence] in Urine by Test strip

276

1.85

1.34

7.2

3.9

0.00

estimate

—

(3002032) Base excess in Venous blood by calculation

2.24

1.34

3.6

3.0

4.28

2.96

mmol/l

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.67

1.34

3.2

3.0

0.77

0.63

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.11

1.30

1.6

1.5

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.08

1.25

4.6

5.7

0.96

1.03

mmol/l

0.36

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.46

1.22

4.2

4.3

55.02

45.10

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.46

1.22

1.5

—

(36304419) Bacteria [Presence] in Urine

140

1.80

1.21

5.0

2.8

—

estimate

—

(3027945) Reticulocytes/Erythrocytes in Blood

2.17

1.20

4.8

3.5

2.15

1.82

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.52

1.17

4.1

3.3

115.29

130.70

g/l

—

(3035350) Ketones [Presence] in Urine by Test strip

273

1.75

1.16

7.2

4.0

0.00

23.88

estimate

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.08

1.09

1.7

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.04

1.04

2.9

1.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

128

1.73

1.04

9.2

5.6

—

(3029937) Albumin [Presence] in Urine by Test strip

156

1.68

1.00

8.2

4.1

0.00

estimate

—

(3000492) Spirometry study

2.02

0.98

2.3

1.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

271

1.65

0.98

7.5

4.0

0.00

estimate

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.19

0.92

13.8

13.3

93.75

95.58

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.82

0.90

2.7

1.8

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

227

1.58

0.86

5.4

4.7

34.46

35.36

g/l

0.38

218

(3015736) pH of Urine

218

1.57

0.85

5.8

3.5

6.61

6.12

1.10

122

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

384

1.68

0.79

10.6

9.5

81.36

80.00

u/l

0.04

358

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

146

1.58

0.79

3.7

2.5

63.20

55.26

u/l

0.71

136

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

212

1.53

0.77

7.0

3.9

0.00

estimate

—

(3022096) Basophils/Leukocytes in Blood

232

1.52

0.75

15.9

6.2

0.64

0.71

0.25

222

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.09

0.75

3.6

3.1

1.16

1.54

—

(3044640) Blood type and Crossmatch panel - Blood

148

1.55

0.74

2.4

—

(3019069) Monocytes/Leukocytes in Blood

234

1.50

0.71

16.1

6.2

8.68

8.73

0.04

225

(3006504) Eosinophils/Leukocytes in Blood

234

1.50

0.71

16.0

6.1

2.04

2.63

1.60

225

(3018010) Neutrophils/Leukocytes in Blood

234

1.50

0.71

15.6

6.1

60.36

57.71

0.61

227

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.74

0.66

1.6

—

(3002030) Lymphocytes/Leukocytes in Blood

238

1.45

0.63

16.3

6.3

25.29

27.15

0.47

230

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

209

1.46

0.63

2.0

2.2

94.25

99.01

pmol/l

0.34

112

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.85

0.61

9.5

9.8

23.15

25.48

mmol/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.57

0.57

1.5

—

(3017732) Neutrophils [#/volume] in Blood

1.51

0.56

3.3

3.6

4.14

4.50

e9/l

—

(3026008) Bacteria identified in Urine by Culture

148

1.43

0.53

6.2

2.8

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.57

0.51

9.7

8.1

106.30

104.35

mmol/l

—

(3002179) Metamyelocytes/Leukocytes in Blood

1.59

0.51

3.1

4.3

—

0.75

—

(40761511) CBC panel - Blood by Automated count

480

1.70

0.50

25.7

14.5

—

(1761868) Lipid panel - Serum or Plasma

192

0.70

0.49

3.7

3.2

—

(3025159) Blasts/Leukocytes in Blood

1.49

0.48

4.1

4.6

—

1.00

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.42

0.0

2.7

—

2.61

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.52

0.41

7.0

2.9

123.00

69.68

ng/l

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.37

0.35

1.3

—

(40761536) Microorganisms panel - Urine sediment

1.39

0.33

5.3

3.2

—

(3009508) Creatinine [Moles/volume] in Urine

161

1.27

0.29

4.5

3.0

7.63

7.37

mmol/l

0.07

130

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

446

0.77

0.28

7.1

6.2

39.57

39.33

mmol/mol

0.07

418

(3013512) EKG study

178

0.79

0.27

5.4

3.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

154

1.25

0.25

5.8

3.5

0.00

estimate

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

213

1.22

0.24

2.9

2.8

—

estimate

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

1.4

—

92.30

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

373.26

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.8

—

1914.88

—

(3021788) Differential panel - Synovial fluid

0.00

0.21

0.0

1.3

—

(3022313) Gas panel - Capillary blood

0.00

0.21

0.0

3.8

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3012516) Albumin [Mass/volume] in Urine

158

1.21

0.19

4.0

3.0

11.67

82.21

mg/l

1.78

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

110

1.24

0.19

1.6

1.3

0.58

2.61

u/ml

—

(3026493) Urate [Moles/volume] in Serum or Plasma

130

0.81

0.18

2.7

2.8

293.18

315.99

umol/l

0.36

114

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

495

1.34

0.18

21.3

13.2

32.10

23.29

u/l

0.87

483

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

278

1.17

0.17

3.4

2.9

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

482

1.35

0.17

32.6

18.7

139.32

140.00

mmol/l

1.04

473

(3023103) Potassium [Moles/volume] in Serum or Plasma

481

1.37

0.17

34.6

18.8

4.00

3.96

mmol/l

0.63

471

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

1.12

0.16

2.8

2.6

25.67

24.59

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

472

1.30

0.16

28.7

16.7

18.62

22.85

mg/l

0.70

370

(3022145) Colonoscopy Study observation

1.15

0.09

1.0

1.3

—

(3003694) ABO and Rh group [Type] in Blood

123

0.87

0.09

1.1

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.80

0.09

13.0

8.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.04

0.09

2.0

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.07

0.08

1.3

1.4

—

(40768797) Stomach Pathology biopsy report

0.86

0.07

1.4

1.3

—

(40768804) Tissue Pathology biopsy report

213

0.91

0.07

2.4

2.0

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

233

0.91

0.07

4.0

3.0

190.36

101.51

ug/l

0.53

217

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.15

0.07

2.0

2.5

2.58

2.40

g/l

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

102

0.86

0.07

2.7

1.9

564.22

539.33

pmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

109

1.13

0.07

2.3

2.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

199

1.09

0.05

5.1

4.1

29.62

23.29

ng/l

0.22

134

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

372

1.07

0.02

5.8

4.4

10.34

11.77

mm/h

0.38

343

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

392

0.98

0.00

42.4

21.0

330.90

330.60

g/l

0.06

392

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.3

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.2

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

1.73

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

497

1.06

0.00

36.0

21.5

77.48

75.89

umol/l

0.08

489

(3011648) Oxygen content in Venous blood

0.00

0.0

1.3

—

9.92

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

450

1.00

-0.00

6.5

5.6

1.76

1.92

mu/l

0.42

406

(3000963) Hemoglobin [Mass/volume] in Blood

502

1.18

-0.00

44.9

25.6

130.80

132.94

g/l

0.46

497

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

-0.00

0.0

1.6

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.1

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.90

-0.00

1.7

1.4

—

(3033306) Mononuclear cells/Leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3022948) Iron [Moles/volume] in Serum or Plasma

0.94

-0.00

2.2

2.4

14.81

15.44

umol/l

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.6

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.4

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

7.7

—

159.39

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3042936) Bacteria identified in Isolate by Culture

1.01

-0.00

1.5

2.1

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

-0.00

0.0

2.5

—

57.00

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

13.00

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.00

-0.00

4.8

4.0

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.1

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: G6_MYASTHENIA_ADVERSE – Myasthenia gravis, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).

NAME	G6_MYASTHENIA_ADVERSE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC	ANY
HD_ICD_10	G700
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

≡ Risteys

R14

FinnGen R13 + FinRegistry

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Myasthenia gravis, drug-induced

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Myasthenia gravis, drug-induced (G6_MYASTHENIA_ADVERSE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints