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Communicating hydrocephalus

DOID EFO Endpoint Browser PheWeb

G6_HCCOMM

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G91.0
  • Hospital discharge: ICD-9 — 3313
  • Cause of death: ICD-10 — G91.0
  • Cause of death: ICD-9 — 3313

2 out of 7 registries used, show all original rules.

918

4. Check minimum number of events

None

918

5. Include endpoints

None

918

6. Filter based on genotype QC (FinnGen only)

806

Control definitions (FinnGen only)

Control exclude
G6_HYDROCEPH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G91
Name in latin
Hydrocephalia communicans

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6750 3351 3305
Only index persons 4677 2460 2217
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.09
Only index persons 0.09 0.09 0.08
Median age at first event (years)
Whole population 59.21 61.43 56.68
Only index persons 55.27 58.24 51.98

-FinnGen-

Key figures

All Female Male
Number of individuals 806 427 379
Unadjusted period prevalence (%) 0.16 0.15 0.17
Median age at first event (years) 61.21 60.52 61.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
822
Matched controls
8220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
23.6
312.1
248
148
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
307.7
290
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
307.7
751
*
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
83.3
307.7
197
31
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
8574.1
307.7
441
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
43.9
257.1
157
44
AA1AA
NOMESCO Finland
Head X-ray examination
61.1
251.9
142
28
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
2814.8
243.2
223
*
AAF00
NOMESCO Finland
Ventriculostomy
471.3
218.3
209
6
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
189.1
174
*
AA1AD
NOMESCO Finland
CT of head and brain
7.4
178.1
551
1763
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
177.7
164
*
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
69.4
158.8
87
14
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
37.8
149.8
94
28
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
45.6
144.2
86
21
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
59.7
126.2
71
13
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
122.0
114
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
113.2
106
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
109.9
103
*
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
20.5
108.7
85
46
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
8.9
106.9
147
197
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
+∞
100.1
94
*
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
42.3
97.4
59
15
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
18.7
92.1
75
44
N03AX14
ATC
levetiracetam; systemic
11.7
88.2
95
91
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
83.8
79
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.7
81.0
175
372
ZXD05
NOMESCO Finland
Urgent procedure
3.9
80.5
404
1635
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
774.1
73.4
71
*
XA800
NOMESCO Finland
Neuropsychological investigation
7.8
69.3
103
149
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
8.4
69.2
96
128
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.1
68.9
76
75
K90
ICPC
Stroke/cerebrovascular accident
8.4
65.3
90
119
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
11.3
62.0
67
64
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
11.1
61.3
67
65
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
11.3
60.2
65
62
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
621.0
59.5
58
*
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
56.9
54
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.6
56.6
237
822
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
22.1
56.2
42
20
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.4
55.7
161
429
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
155.8
55.6
58
*
2132
FHL
Ventricular operators sunt
574.9
55.2
54
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.4
53.5
82
122
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
52.6
255
965
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
52.1
285
1159
K91
ICPC
Cerebrovascular disease
12.5
51.9
52
44
N03AB02
ATC
phenytoin; systemic
11.5
46.3
49
45
R51.80
ICD-10 Finland
Headache
3.4
45.7
206
739
N03AG01
ATC
valproic acid; systemic, rectal
4.9
44.5
106
240
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
+∞
43.1
41
*
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
8.1
42.1
58
76
N18
ICPC
Paralysis/weakness
8.6
41.9
55
68
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
13.6
41.1
39
30
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
56.5
40.9
48
9
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
79.4
40.3
45
6
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.1
39.7
123
341
Z2445
NOMESCO Finland
Psychologist
6.0
39.6
73
131
N03AF02
ATC
oxcarbazepine; oral
6.7
39.5
65
104
ZXD35
NOMESCO Finland
Usual procedure
6.4
38.5
66
110
N28
ICPC
Limited function/disability (N)
9.5
38.1
46
51
ZXE10
NOMESCO Finland
More than one and less than three hours
2.6
37.9
385
2100
N29
ICPC
Neurological sympt/complt other
9.1
36.1
45
52
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
7.5
35.5
52
73
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.5
33.9
57
93
TAB00
NOMESCO Finland
Lumbar puncture
4.7
33.2
81
186
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.1
32.7
161
599
N99
ICPC
Neurological disease other
11.0
31.5
34
32
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
11.9
31.1
32
28
G91.3
ICD-10 Finland
Post-traumatic hydrocephalus, unspecified
+∞
30.4
29
*
L28
ICPC
Limited function/disability (L)
2.6
29.7
234
1109
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
9.6
29.3
35
38
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
8.4
28.8
38
47
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.5
28.6
106
330
PA2MT
NOMESCO Finland
Endovascular closure of very extensive brain aneurysm
150.1
27.8
29
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.2
27.7
79
205
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.9
27.4
38
50
I60.6
ICD-10 Finland
Subarachnoid haemorrhage from other intracranial arteries
77.9
26.9
30
*
2133
FHL
Suntin revisio
279.8
26.9
27
*
R42
ICD-10 Finland
Dizziness and giddiness
2.4
26.8
260
1346
SPAT1229
SPAT
Assessment of need for aid
3.3
26.3
107
353
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.4
26.2
104
338
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
+∞
26.2
25
*
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
26.2
25
*
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
+∞
26.2
25
*
N03AF01
ATC
carbamazepine; oral, rectal
3.8
24.9
80
226
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.9
24.7
136
534
XCK00
NOMESCO Finland
Perimetry
3.5
24.6
89
272
M03BX01
ATC
baclofen; systemic
6.6
24.6
40
63
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
24.3
342
2045
I60.3
ICD-10 Finland
Subarachnoid haemorrhage from posterior communicating artery
57.9
24.2
28
5
H47.2
ICD-10 Finland
Optic atrophy
32.1
23.8
31
10
A28
ICPC
Limited function/disability NOS
2.3
23.4
222
1128
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
5.3
23.3
48
95
R4120
NOMESCO Finland
Occupational therapy
3.4
23.2
88
277
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
31.1
22.9
30
10
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.1
22.7
64
164
G91
ICD-10 Finland
Hydrocephalus
+∞
22.0
21
*
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
39.8
21.8
27
7
SPAT1216
SPAT
Assessment of functional ability
2.4
21.7
180
860
R1250
NOMESCO Finland
Evaluation of functional capability
5.2
21.6
45
90
-, ,
ICD-10 Finland
5.2
21.6
45
90
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
34.8
21.2
27
8
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
7.3
20.9
31
44
H53.4
ICD-10 Finland
Visual field defects
5.3
20.7
42
82
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.1
20.7
93
325
ZXA00
NOMESCO Finland
Right side
2.1
19.9
272
1584
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.8
19.4
103
395
2161
FHL
Neck ligation, big brain
32.2
19.3
25
8
AA1BD
NOMESCO Finland
Extensive CT of head and brain
5.3
19.3
39
76
GBB00
NOMESCO Finland
Tracheostomy
8.1
19.2
26
33
4300A
ICD-9 Finland
Subarachnoid haemorrhage[HAEMORRHAGIA SUBARACHNOID. POST ANEURYSMA SACCULARE]
26.8
19.2
26
10
F03
ICD-10 Finland
Unspecified dementia
3.3
19.0
76
247
P20
ICPC
Memory disturbance
2.3
19.0
169
829
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
18.9
246
1402
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
17.6
18.8
29
17
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
8.0
18.4
25
32
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.0
18.3
85
302
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.7
18.3
109
443
A06AD11
ATC
lactulose; oral
2.2
18.2
180
920
R4150
NOMESCO Finland
Neuropsychological rehabilitation
15.8
18.1
29
19
N06AB04
ATC
citalopram; systemic
2.1
18.1
205
1107
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
17.9
346
2254
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.1
17.9
78
267
SPAT1234
SPAT
Support of social functional capacity
3.2
17.2
70
230
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.6
16.9
57
166
G04BD07
ATC
tolterodine; oral
3.2
16.8
69
228
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.8
16.4
30
53
N05BA09
ATC
clobazam; oral
15.7
16.3
26
17
S06.0
ICD-10 Finland
Concussion
2.4
15.9
121
552
T90.5
ICD-10 Finland
Sequelae of intracranial injury
7.0
15.8
24
35
2130
FHL
Ventricular atrial shunt
+∞
15.7
15
*
I60.8
ICD-10 Finland
Other subarachnoid haemorrhage
86.8
15.6
17
*
I60.4
ICD-10 Finland
Subarachnoid haemorrhage from basilar artery
86.8
15.6
17
*
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
4.6
15.5
37
83
AAK00
NOMESCO Finland
Cranioplasty
163.0
15.5
16
*
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.7
15.4
50
142
183
Kela drug reimbursment
Lamotrigin and topiramate
11.6
15.4
28
25
AA5PD
NOMESCO Finland
CT examination of brain pefusion
6.7
15.0
24
37
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
13.5
14.8
25
19
AAF10
NOMESCO Finland
Lumboperitoneal shunt
+∞
14.6
14
*
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
2.5
14.6
98
421
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
5.5
14.6
28
52
2124
FHL
Intracranial pressure measurement, intraventricular
152.6
14.5
15
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.9
14.3
32
68
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
14.3
145
744
G41.9
ICD-10 Finland
Status epilepticus, unspecified
19.6
14.3
21
11
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
3.5
14.2
50
150
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.1
14.1
157
834
R11
ICD-10 Finland
Nausea and vomiting
2.5
13.9
98
430
JDB10
NOMESCO Finland
Percutaneous gastrostomy
6.4
13.8
23
37
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
13.6
136
693
Z3229
NOMESCO Finland
Other healthcare associate professional
2.5
13.6
92
397
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
142.3
13.5
14
*
G81.1
ICD-10 Finland
Spastic hemiplegia
142.3
13.5
14
*
AAK80
NOMESCO Finland
Partial excision of skull cap
142.3
13.5
14
*
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
142.3
13.5
14
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.3
13.3
107
498
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.0
13.3
160
874
PA2AD
NOMESCO Finland
CT angiography of brain
14.1
13.3
22
16
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.6
13.2
81
333
R53
ICD-10 Finland
Malaise and fatigue
1.8
13.1
235
1465
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
11.2
13.1
24
22
AAD05
NOMESCO Finland
Evacuation of acute subdural haematoma
17.1
13.0
20
12
N05AH04
ATC
quetiapine; oral
2.0
12.9
159
875
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
32.6
12.6
16
5
2139
FHL
Other measure in this category
+∞
12.5
12
*
W19
ICD-10 Finland
Unspecified fall
2.2
12.2
106
510
G40.10
ICD-10 Finland
Simple partial seizures
12.6
12.2
21
17
N03AX09
ATC
lamotrigine; oral
3.2
12.2
49
160
S06.3
ICD-10 Finland
Focal brain injury
5.6
11.7
22
40
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.3
11.6
97
458
G03.9
ICD-10 Finland
Meningitis, unspecified
23.3
11.6
16
7
N03AX18
ATC
lacosamide; systemic
11.3
11.6
21
19
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
9.4
11.5
23
25
Q03.9
ICD-10 Finland
Congenital hydrocephalus, unspecified
+∞
11.5
11
*
N05AX08
ATC
risperidone; systemic
2.2
11.5
101
488
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
121.7
11.5
12
*
N05BA01
ATC
diazepam; systemic, rectal
2.0
11.2
125
662
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
5.8
11.0
20
35
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
5.8
11.0
20
35
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.0
10.9
48
165
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
15.7
10.9
17
11
U04
ICPC
Incontinence urine
2.5
10.8
72
308
R41.0
ICD-10 Finland
Disorientation, unspecified
3.1
10.7
45
151
G44.2
ICD-10 Finland
Tension-type headache
2.0
10.6
120
638
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.0
10.5
116
611
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
5.5
10.4
20
37
G97.2
ICD-10 Finland
Intracranial hypotension following ventricular shunting
+∞
10.4
10
*
2127
FHL
Ventriculostomy
+∞
10.4
10
*
AAK85
NOMESCO Finland
Replantation of previously excised part of skull cap
+∞
10.4
10
*
GBB03
NOMESCO Finland
Percutaneous tracheostomy
+∞
10.4
10
*
ZXC86
NOMESCO Finland
Use of endoscopic device
16.3
10.4
16
10
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
33.0
10.4
13
*
R51
ICD-10 Finland
Headache
2.9
10.3
50
182
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
4.6
10.3
24
53
N05AH03
ATC
olanzapine; systemic
2.6
10.2
58
230
N05CD08
ATC
midazolam; nasal, systemic
3.5
10.1
35
104
A04
ICPC
Weakness/tiredness general
1.9
10.1
145
837
WYA20
NOMESCO Finland
Home visit
3.8
10.1
31
85
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
9.3
10.1
20
22
I60.5
ICD-10 Finland
Subarachnoid haemorrhage from vertebral artery
40.6
10.0
12
*
SPAT1053
SPAT
Memory test
1.9
9.8
137
784
Z3231
NOMESCO Finland
Registered nurse
1.7
9.6
232
1558
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
10.2
9.5
18
18
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
101.2
9.4
10
*
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
17.8
9.4
14
8
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
+∞
9.4
9
*
GBB13
NOMESCO Finland
Revision of tracheostomy
+∞
9.4
9
*
TGB20
NOMESCO Finland
Tracheostomy tube replacement
+∞
9.4
9
*
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
8.2
9.4
20
25
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.2
9.3
36
115
D33.30
ICD-10 Finland
Acoustic neuroma
13.9
9.2
15
11
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
9.2
248
1709
Z75.5
ICD-10 Finland
Holiday relief care
5.1
9.1
19
38
RS221, ,
NOMESCO Finland
4.7
9.1
21
46
D32.0
ICD-10 Finland
Benign neoplasm: Cerebral meninges
15.8
9.1
14
9
G41.0
ICD-10 Finland
Grand mal status epilepticus
37.1
9.0
11
*
Z43.0
ICD-10 Finland
Attention to tracheostomy
37.1
9.0
11
*
Z3226
NOMESCO Finland
Physiotherapist
1.8
8.9
158
970
N06AB10
ATC
escitalopram; oral
1.8
8.9
151
915
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
12.7
8.9
15
12
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
8.9
158
972
OAB43, ,
SPAT
0.4
8.9
46
1063
SPAT1231
SPAT
Assessment of adjustments needed in living environment
3.9
8.8
26
69
Z03
ICPC
Housing/neighbourhood problem
9.6
8.8
17
18
R5110, ,
SPAT
2.1
8.7
86
434
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
8.7
159
985
T85.7
ICD-10 Finland
Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
50.5
8.7
10
*
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
7.8
8.7
19
25
R32
ICD-10 Finland
Unspecified urinary incontinence
3.2
8.6
34
110
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
6.5
8.5
21
33
XFP96
NOMESCO Finland
Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation
3.7
8.5
26
71
AWE00
NOMESCO Finland
Reoperation for deep heamorrhage in surgery of the nervous system
27.8
8.5
11
*
R26.0
ICD-10 Finland
Ataxic gait
20.3
8.5
12
6
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
8.4
95
1655
G40
ICD-10 Finland
Epilepsy
6.8
8.4
20
30
Q03.0
ICD-10 Finland
Malformations of aqueduct of Sylvius
+∞
8.3
8
*
I60
ICD-10 Finland
Subarachnoid haemorrhage
+∞
8.3
8
*
G90.1
ICD-10 Finland
Familial dysautonomia [Riley-Day]
+∞
8.3
8
*
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
8.3
8
*
34793
ICD-8 Finland
Other disease of brain, Hydrocephalus acquisitus NUD
+∞
8.3
8
*
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
2.5
8.3
52
216
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
7.2
8.3
19
27
R4110
NOMESCO Finland
Physiotherapy
1.6
8.2
230
1594
SPAT1301
SPAT
No procedures
1.6
8.1
255
1814
I69.2
ICD-10 Finland
Sequelae of other nontraumatic intracranial haemorrhage
17.4
8.1
12
7
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
8.1
148
917
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.6
8.0
45
177
G04BD09
ATC
trospium; oral
3.3
8.0
30
94
Z08
ICPC
Social welfare problem
4.5
7.9
19
43
F06.7
ICD-10 Finland
Mild cognitive disorder
2.8
7.9
38
138
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.5
7.9
49
203
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
0.5
7.8
73
1357
N05AD01
ATC
haloperidol; systemic
3.0
7.8
34
117
R55
ICD-10 Finland
Syncope and collapse
1.9
7.6
108
618
Z43.5
ICD-10 Finland
Attention to cystostomy
8.1
7.6
16
20
R1260
NOMESCO Finland
Evaluation of communicative skills
3.5
7.6
25
72
SPAT1252
SPAT
Overall medication plan or its review
2.2
7.6
67
324
RL140, ,
NOMESCO Finland
25.3
7.6
10
*
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
4.2
7.6
20
49
H47.1
ICD-10 Finland
Papilloedema, unspecified
10.2
7.5
14
14
M01AH05
ATC
etoricoxib; oral
0.7
7.5
294
3774
G04BD08
ATC
solifenacin; oral
2.2
7.5
66
319
WX882
NOMESCO Finland
High dependency care
2.9
7.5
34
120
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
7.4
92
504
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
7.7
7.4
16
21
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
6.1
7.4
19
32
ZXA05
NOMESCO Finland
Left side
1.6
7.4
207
1429
N88
ICPC
Epilepsy
8.5
7.3
15
18
RP120, ,
NOMESCO Finland
+∞
7.3
7
*
74200
ICD-8 Finland
Congenital hydrocephalus, Communicans
+∞
7.3
7
*
74209
ICD-8 Finland
Congenital hydrocephalus, Unspecified
+∞
7.3
7
*
G94.2
ICD-10 Finland
Hydrocephalus in other diseases classified elsewhere
+∞
7.3
7
*
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.9
7.3
88
478
A29
ICPC
General symptom/complaint other
1.8
7.2
124
752
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.6
7.2
23
65
AAA27
NOMESCO Finland
Insertion of intracerebral pressure monitoring device
30.3
7.2
9
*
4309X
ICD-9 Finland
Subarachnoid haemorrhage[HAEMORRHAGIA SUBARACHNOIDALIS NUD]
30.3
7.2
9
*
AA9CW, ,
NOMESCO Finland
20.2
7.1
10
5
XX4AW, ,
NOMESCO Finland
20.2
7.1
10
5
G40.89
ICD-10 Finland
Other epilepsy
10.1
7.0
13
13
R4130
NOMESCO Finland
Speech therapy
3.0
7.0
30
102
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.3
7.0
50
221
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
6.4
7.0
17
27
H53.2
ICD-10 Finland
Diplopia
2.8
6.9
34
125
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
4.0
6.9
19
48
RS313, ,
NOMESCO Finland
13.9
6.9
11
8
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
40.4
6.8
8
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.2
6.8
54
251
Z2446
NOMESCO Finland
Social worker
2.1
6.7
62
305
G41.2
ICD-10 Finland
Complex partial status epilepticus
22.7
6.7
9
*
WX704
NOMESCO Finland
Intubation
2.1
6.7
66
334
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
6.6
104
614
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
7.9
6.6
14
18
XKC03
NOMESCO Finland
Water cystometry
2.8
6.6
32
117
G93.0
ICD-10 Finland
Cerebral cysts
12.4
6.6
11
9
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
8.8
6.6
13
15
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
10.1
6.5
12
12
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
2.4
6.5
45
196
J01EA01
ATC
trimethoprim; systemic
1.5
6.5
212
1511
G00.3
ICD-10 Finland
Staphylococcal meningitis
70.4
6.4
7
*
L01AX03
ATC
temozolomide; systemic
7.5
6.4
14
19
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
6.4
104
620
N05AD03
ATC
melperone; systemic
3.6
6.3
20
56
N19
ICPC
Speech disorder
3.6
6.3
20
56
XX1XW
NOMESCO Finland
Extensive written report from radiologist
3.4
6.3
22
66
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
11.1
6.3
11
10
L29
ICPC
Musculoskeletal sympt/complt other
1.9
6.3
75
406
Q05.2
ICD-10 Finland
Lumbar spina bifida with hydrocephalus
+∞
6.3
6
*
PA7RT
NOMESCO Finland
Medical infusion to cerebral artery
+∞
6.3
6
*
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
+∞
6.3
6
*
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
+∞
6.3
6
*
SPAT1063
SPAT
Suctioning of mucus from airways
+∞
6.3
6
*
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
3.7
6.2
19
52
N05AB03
ATC
perphenazine; systemic, rectal
2.7
6.2
32
121
SPAT1042
SPAT
Guidance concerning balance maintenance
12.6
6.1
10
8
Z29
ICPC
Social problem NOS
3.1
6.1
24
78
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
8.7
6.1
12
14
SPAT1100
SPAT
Long-term monitoring of blood pressure
2.0
6.1
61
311
RT150, ,
NOMESCO Finland
10.1
6.0
11
11
N06DA02
ATC
donepezil; oral
2.0
6.0
69
368
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
0.4
6.0
23
612
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
5.6
6.0
16
29

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
178
61
36.97
275.65
4.3
1.1
—
—
—
0
0
222
150
19.91
261.11
3.7
1.6
33.48
10.98
e6/l
1.31
166
104
222
152
19.64
259.28
3.7
1.7
2174.52
913.55
e6/l
0.57
166
110
184
131
17.81
208.85
3.9
1.7
—
—
—
0
0
125
77
18.97
151.39
3.8
2.1
—
—
—
0
0
216
914
2.85
34.99
10.4
8.4
1.43
1.06
mmol/l
0.92
174
763
216
922
2.82
34.35
10.4
8.3
4.99
5.12
kpa
1.30
211
891
216
923
2.82
34.27
10.4
8.3
13.95
11.89
kpa
5.24
211
894
215
921
2.81
33.92
10.5
8.3
7.41
7.42
ph
0.12
148
550
37
47
8.20
27.45
1.2
1.0
277.33
301.07
ng/l
0.13
15
30
37
47
8.20
27.45
1.2
1.0
479.00
594.70
ng/l
0.64
14
30
136
509
3.00
27.06
12.6
10.0
1.28
1.33
%
0.27
136
504
185
829
2.59
26.00
11.3
8.8
97.09
95.24
%
7.91
180
804
172
770
2.56
24.07
12.1
8.8
122.14
120.56
g/l
0.50
167
755
30
9
34.52
23.47
2.8
1.0
31.96
—
%
—
24
0
125
499
2.77
21.87
13.8
7.3
24.65
24.35
mmol/l
0.33
119
479
106
2341
0.37
20.88
2.6
3.3
—
—
—
0
0
358
2293
1.99
20.11
3.0
2.2
219.73
271.92
u/l
0.46
338
2185
298
1798
2.03
19.74
5.3
4.4
90.13
87.87
%
0.92
288
1766
292
1754
2.03
19.54
2.7
2.5
—
—
—
0
0
213
1195
2.06
16.82
2.4
2.2
28.42
29.47
s
1.65
206
1159
348
2349
1.83
15.55
4.9
3.5
—
—
—
0
0
108
473
2.48
15.47
10.6
10.1
24.45
24.48
mmol/l
0.04
108
464
325
2169
1.82
14.91
4.6
4.4
—
—
—
0
0
340
2317
1.80
14.44
3.0
2.6
—
—
—
0
0
128
639
2.19
13.48
2.7
2.5
5.02
6.81
ug/l
0.49
114
561
259
1675
1.80
12.79
5.7
4.4
1.02
1.02
kg/l
2.12
177
1131
177
1055
1.86
11.22
5.5
6.3
1.00
1.07
mmol/l
2.57
170
974
126
704
1.93
9.64
10.4
9.3
—
—
—
0
0
435
3419
1.58
9.31
9.9
7.1
1.20
1.21
mmol/l
3.18
415
3152
558
6355
0.62
8.79
4.4
5.2
1.41
1.46
mmol/l
2.20
528
5816
563
6392
0.62
8.63
4.6
5.3
4.47
4.55
mmol/l
1.08
533
5896
286
2090
1.57
8.12
5.7
4.3
0.00
0.00
estimate
0.74
54
729
579
6508
0.63
8.06
5.4
6.1
2.57
2.63
mmol/l
1.06
549
5972
562
6353
0.64
7.93
4.8
5.4
6.00
6.00
mmol/l
0.00
539
5760
49
203
2.50
7.89
8.1
11.0
—
—
—
0
0
122
719
1.82
7.85
9.4
8.2
1.33
1.33
mmol/l
0.00
122
707
190
1272
1.64
7.73
3.7
3.7
0.84
0.82
mmol/l
2.04
181
1201
533
6084
0.65
7.72
4.1
4.5
1.36
1.28
mmol/l
1.69
504
5523
42
164
2.65
7.63
1.6
1.4
99.89
59.27
mmol/l
3.56
36
135
34
832
0.38
7.41
1.1
1.3
—
—
—
0
0
166
1096
1.64
7.08
2.4
2.1
—
—
—
0
0
543
4629
1.51
7.05
7.0
5.1
11335.00
2556.48
e6/l
—
5
85
400
3238
1.46
6.54
3.2
2.9
—
—
estimate
—
0
0
500
4241
1.46
6.28
9.8
5.6
6.87
6.72
mmol/l
0.93
491
4041
313
2436
1.46
6.19
4.5
3.6
41.46
86.55
e6/l
0.88
252
1883
188
1335
1.53
5.79
3.8
3.2
1.66
1.23
e6/l
0.50
103
735
559
6218
0.68
5.75
6.2
6.8
39.43
39.69
mmol/mol
0.29
533
5789
367
4368
0.71
5.40
3.3
3.4
53.93
50.89
u/l
0.31
344
4078
115
742
1.64
5.31
3.1
3.8
4.96
4.51
kpa
0.91
110
718
400
3321
1.40
5.27
5.3
5.3
34.29
35.37
g/l
3.37
378
3115
132
892
1.57
5.03
2.3
1.7
—
—
—
0
0
124
826
1.59
5.03
3.6
4.4
1.17
1.74
mmol/l
0.87
108
696
224
1698
1.44
4.89
3.1
2.8
5.13
5.61
e6/l
0.24
213
1553
127
858
1.57
4.84
3.7
4.4
5.79
5.73
kpa
0.20
122
832
254
1978
1.41
4.75
4.3
3.4
—
0.00
estimate
—
0
13
267
2101
1.40
4.69
4.3
3.5
0.35
0.50
e6/l
0.83
207
1566
360
2992
1.36
4.48
4.7
3.8
6.65
6.23
ph
8.80
183
1675
441
3796
1.35
4.30
10.3
7.7
1.20
1.21
mmol/l
1.32
408
3287
148
1997
0.68
4.20
4.5
3.7
0.00
0.05
estimate
0.69
43
626
220
2762
0.72
4.08
1.9
2.0
1.41
1.33
mmol/l
0.80
200
2287
123
857
1.51
4.07
3.6
4.5
7.37
7.38
ph
0.42
79
504
26
553
0.45
4.03
6.3
4.0
—
—
—
0
0
202
1554
1.40
3.97
2.9
3.0
2.46
2.46
mmol/l
0.12
182
1397
60
971
0.59
3.88
1.2
1.3
—
—
—
0
0
326
2717
1.33
3.81
5.8
4.3
77.86
85.76
e6/l
0.13
249
1954
20
460
0.42
3.80
1.5
1.4
—
—
—
0
0
215
2683
0.73
3.77
2.2
2.2
—
—
—
0
0
16
403
0.39
3.76
1.6
1.8
3.20
3.46
mmol/l
—
9
288
429
3725
1.32
3.72
5.3
4.3
0.00
4.32
estimate
0.80
62
810
424
3684
1.31
3.63
5.3
4.2
0.00
0.00
estimate
-0.00
60
787
35
644
0.52
3.57
1.2
1.5
—
—
—
0
0
57
914
0.60
3.56
1.2
1.3
—
—
—
0
0
274
2247
1.33
3.52
4.3
4.3
7.40
7.40
ph
0.33
192
1611
88
1274
0.65
3.52
1.3
1.3
35.67
32.47
iu/ml
0.10
32
400
405
3511
1.30
3.46
12.8
16.4
1.21
1.29
inr
2.14
329
2942
430
3759
1.30
3.45
5.3
4.3
0.00
0.41
estimate
0.52
60
761
162
1230
1.39
3.40
4.6
3.4
2.43
2.15
e6/l
0.16
80
631
310
2597
1.31
3.40
3.1
3.6
2.36
2.36
mmol/l
0.01
280
2346
6
208
0.28
3.39
4.8
5.3
—
—
—
0
0
80
1165
0.65
3.28
1.3
1.3
12.64
10.30
u/ml
0.16
27
425
653
6919
0.73
3.26
12.6
12.7
25.55
25.35
u/l
0.11
638
6708
39
675
0.56
3.25
1.4
1.5
—
—
—
0
0
51
814
0.60
3.13
3.3
4.3
11.43
23.95
ug/l
0.51
44
683
274
3235
0.77
3.08
3.2
3.1
109.92
136.02
ug/l
1.91
258
2982
34
594
0.55
2.94
1.4
1.5
—
—
—
0
0
35
194
1.84
2.84
4.9
3.4
1.50
2.22
index
0.38
20
108
203
2472
0.76
2.83
4.1
4.1
7.92
9.02
mg/mmol
0.16
135
1549
588
5428
1.29
2.78
32.2
23.2
331.87
331.85
g/l
0.02
581
5388
326
2810
1.27
2.72
5.3
4.2
0.00
0.04
estimate
2.65
41
662
6
183
0.32
2.70
5.2
3.5
6.32
7.79
mmol/l
—
6
178
16
67
2.42
2.64
2.4
3.2
15.89
12.78
index
—
9
46
8
20
4.03
2.57
2.0
2.2
0.61
0.60
mmol/l
—
8
20
40
641
0.60
2.52
5.8
5.0
0.85
0.17
%
0.40
13
169
69
979
0.68
2.49
1.3
1.4
898.82
443.80
titre
0.72
17
221
685
7156
0.74
2.49
35.5
26.9
131.29
133.95
g/l
4.78
674
7067
201
2417
0.78
2.49
3.8
3.4
44.36
50.87
mg/l
0.21
137
1555
9
26
3.49
2.48
1.1
1.0
1681.22
1588.73
miu/ml
—
9
26
685
7153
0.75
2.44
36.3
27.2
39.51
39.95
%
1.68
674
7058
685
7153
0.75
2.44
35.2
26.7
7.22
6.81
e9/l
4.34
671
6973
685
7153
0.75
2.44
35.0
26.5
30.25
30.32
pg
0.41
675
7062
685
7153
0.75
2.44
35.2
26.6
4.37
4.45
e12/l
3.79
671
6973
685
7151
0.75
2.41
35.1
26.6
91.05
91.22
fl
0.43
674
7061
685
7151
0.75
2.41
35.2
26.7
258.37
246.34
e9/l
4.23
670
6995
90
660
1.41
2.33
2.2
2.2
0.00
0.02
estimate
0.50
11
132
41
635
0.63
2.26
5.0
4.7
0.21
0.11
%
0.28
14
186
104
1346
0.74
2.19
2.8
3.3
0.64
0.78
ug/l
1.27
75
888
47
701
0.65
2.19
3.6
4.2
7.32
7.36
ph
0.25
34
511
7
181
0.38
2.17
1.0
1.1
—
—
—
0
0
325
2867
1.22
2.06
3.8
4.1
29.67
68.92
ng/l
1.13
252
2175
7
175
0.39
2.05
1.1
1.2
0.84
0.90
g/l
—
7
175
62
861
0.70
2.01
1.6
2.4
274.73
131.82
ug/g
0.56
52
675
218
2543
0.81
2.01
3.6
3.5
7.36
7.45
mmol/l
0.10
197
2137
582
6160
0.81
1.97
5.2
5.4
1.96
1.97
mu/l
0.10
550
5615
46
670
0.67
1.93
4.7
4.6
1.24
0.95
%
0.32
19
223
62
854
0.70
1.93
1.5
1.6
—
—
—
0
0
43
633
0.66
1.90
4.5
4.5
1.33
0.54
%
0.83
18
203
0
52
0.00
1.88
0.0
2.6
—
574.59
—
0
32
11
237
0.46
1.87
1.6
1.6
—
—
—
0
0
15
289
0.51
1.86
1.1
1.2
—
—
—
0
0
302
3386
0.83
1.83
6.6
6.6
0.64
0.67
%
0.41
292
3167
132
1612
0.78
1.80
1.3
1.3
0.72
1.67
u/ml
2.83
36
422
7
167
0.41
1.80
1.1
1.1
1.71
1.55
g/l
—
7
167
11
232
0.47
1.78
1.1
1.1
—
—
—
0
0
162
1346
1.25
1.78
1.6
1.8
1362.98
1187.86
nmol/l
1.81
136
1007
5
135
0.37
1.76
1.0
1.2
—
—
—
0
0
156
1860
0.80
1.73
2.7
3.0
342.62
347.93
umol/l
0.28
133
1622
37
548
0.66
1.71
3.5
2.4
10.49
13.02
nmol/l
1.54
37
490
310
3451
0.84
1.70
6.4
6.6
26.84
27.23
%
0.24
301
3274
10
211
0.47
1.64
1.1
1.2
—
656.00
—
0
5
5
131
0.38
1.63
1.2
1.1
—
—
—
0
0
68
896
0.74
1.63
4.0
3.2
4.15
5.52
e9/l
1.13
58
784
5
14
3.59
1.61
1.4
1.9
16.20
16.20
umol/l
—
5
14
77
994
0.75
1.61
1.9
1.8
—
—
—
0
0
118
1437
0.79
1.57
1.3
1.5
2.40
2.46
g/l
0.16
65
862
20
114
1.77
1.57
1.2
1.6
—
—
—
0
0
20
114
1.77
1.57
1.2
1.6
—
—
—
0
0
20
114
1.77
1.57
1.2
1.6
—
—
—
0
0
20
114
1.77
1.57
1.2
1.6
—
—
—
0
0
21
347
0.59
1.57
4.5
2.9
41.55
109.04
u/ml
1.03
21
331
307
3400
0.85
1.55
6.3
6.4
58.17
57.52
%
0.40
297
3242
20
333
0.59
1.54
1.1
1.3
—
—
—
0
0
306
3385
0.85
1.51
6.5
6.5
2.69
2.86
%
0.69
294
3169
157
1841
0.82
1.48
1.3
1.4
—
—
—
0
0
677
7004
0.81
1.47
29.0
23.3
74.35
79.39
umol/l
3.97
667
6912
10
202
0.49
1.47
1.1
1.2
—
90.56
—
0
18
7
155
0.45
1.43
1.0
1.1
—
0.67
—
0
28
31
455
0.67
1.40
1.3
1.3
—
—
—
0
0
649
6733
0.83
1.38
20.8
15.7
—
—
—
0
0
129
1531
0.81
1.37
5.1
5.0
—
—
—
0
0
11
209
0.52
1.36
1.5
1.4
—
—
—
0
0
10
196
0.50
1.36
1.6
2.2
133.60
127.59
g/l
—
10
154
82
650
1.29
1.35
3.3
2.6
0.98
0.56
e6/l
0.32
76
624
0
39
0.00
1.34
0.0
1.5
—
70.17
—
0
29
309
3390
0.86
1.33
6.5
6.6
9.07
8.98
%
0.18
296
3180
12
61
1.98
1.33
1.0
1.1
—
—
—
0
0
0
40
0.00
1.33
0.0
2.8
—
495.15
—
0
26
170
1465
1.20
1.32
4.0
3.2
556.51
528.66
mosm/kgh2o
0.93
157
1281
19
114
1.68
1.29
2.1
2.7
—
—
—
0
0
201
2276
0.85
1.28
4.6
5.8
2.82
2.77
ug/l
0.02
184
2034
5
116
0.43
1.26
1.0
1.7
—
—
—
0
0
8
36
2.23
1.24
1.0
1.3
136.88
140.96
nmol/l
—
8
36
45
602
0.73
1.23
2.3
2.9
10.59
10.66
g/l
0.04
40
556
89
725
1.26
1.19
2.5
2.1
457.11
382.96
nmol/l
0.44
83
675
5
20
2.51
1.15
1.0
2.1
11.60
15.76
pmol/l
—
5
14
221
2457
0.86
1.10
2.6
3.3
1273.54
1577.84
ng/l
0.40
197
2127
9
166
0.54
1.08
2.8
3.1
56.74
59.03
%
—
9
166
29
406
0.70
1.07
1.1
1.2
167.11
140.67
u/ml
0.12
14
156
6
125
0.48
1.05
1.2
1.0
—
—
—
0
0
8
148
0.54
1.04
1.6
1.4
0.92
0.84
nmol/l
—
8
122
9
46
1.97
1.03
2.0
3.1
0.67
0.80
index
—
9
46
5
107
0.46
1.01
3.4
2.3
34.00
32.82
pg
—
5
107
6
119
0.50
0.94
3.0
3.4
4.92
4.37
e9/l
—
6
119
11
63
1.76
0.90
1.4
1.2
1.23
1.59
nmol/l
0.58
11
57
45
351
1.30
0.89
2.6
2.0
3.49
2.49
ug/l
0.18
40
315
11
64
1.73
0.86
1.2
1.1
91.27
99.91
pmol/l
0.35
11
64
44
556
0.78
0.85
1.3
1.2
—
—
—
0
0
172
1546
1.14
0.81
1.4
1.8
460.56
22397919.15
pmol/l
1.21
151
1268
24
327
0.73
0.79
1.0
1.6
—
15.50
—
0
9
0
26
0.00
0.78
0.0
3.6
—
6.03
—
0
26
234
2154
1.12
0.76
7.7
6.5
—
—
—
0
0
37
291
1.28
0.72
1.9
2.1
340.21
439.68
ug/l
0.22
32
271
22
297
0.73
0.70
1.0
1.1
—
—
—
0
0
5
91
0.55
0.67
1.4
1.7
—
—
—
0
0
5
95
0.52
0.66
1.4
1.4
—
—
—
0
0
5
28
1.79
0.66
1.0
1.1
—
—
—
0
0
36
287
1.27
0.64
1.4
2.8
10.40
10.65
g/l
0.16
28
258
12
79
1.53
0.63
2.3
5.9
12.07
10.47
%
0.90
12
79
648
6624
0.90
0.61
25.8
17.6
28.52
25.40
mg/l
1.54
574
5506
9
137
0.65
0.61
4.8
2.9
7.66
8.40
pmol/l
—
9
137
9
137
0.65
0.61
1.0
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
1.51
—
0
14
0
21
0.00
0.60
0.0
1.4
—
67.05
—
0
21
297
3141
0.91
0.59
9.8
12.1
0.01
0.01
e9/l
0.13
226
2554
7
113
0.62
0.58
1.6
2.9
—
—
—
0
0
22
286
0.76
0.57
1.8
3.9
547.38
305.68
mg/l
—
8
121
14
98
1.44
0.56
1.7
1.5
20.85
25.52
ng/l
0.47
14
98
5
88
0.57
0.56
1.6
1.3
—
—
—
0
0
10
65
1.55
0.55
1.9
1.3
28.45
29.49
u/l
—
10
53
160
1470
1.11
0.55
4.0
4.3
367.18
364.90
ng/l
0.00
137
1208
8
122
0.65
0.55
1.3
1.5
39.91
31.42
g/l
—
8
109
42
350
1.21
0.53
1.4
2.0
1.62
1.53
g/l
0.23
34
319
6
96
0.62
0.52
1.0
1.4
40.82
64.31
mu/l
—
6
89
6
97
0.62
0.52
1.2
1.3
—
—
—
0
0
28
347
0.80
0.52
1.5
1.3
—
—
—
0
0
10
142
0.70
0.46
2.0
1.5
—
—
—
0
0
5
82
0.61
0.46
2.0
1.6
—
—
—
0
0
8
120
0.66
0.46
6.0
3.8
2.38
1.42
%
—
8
107
5
84
0.59
0.45
1.2
1.2
—
—
—
0
0
399
3852
1.07
0.42
5.7
6.8
11.16
12.35
umol/l
0.88
382
3681
6
92
0.65
0.42
1.2
1.1
—
—
—
0
0
5
32
1.57
0.42
1.0
1.5
1.54
2.10
umol/l
—
5
27
10
139
0.72
0.42
2.3
1.9
—
—
—
0
0
5
33
1.52
0.41
1.8
3.5
517.20
840.30
u/ml
—
5
33
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
4.5
—
7.71
—
0
15
0
15
0.00
0.41
0.0
1.0
—
12.11
—
0
9
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
5.18
—
0
10
235
2230
1.08
0.41
1.7
1.7
19.78
20.35
nmol/l
0.21
217
1859
0
17
0.00
0.40
0.0
1.0
—
1.74
—
0
9
32
269
1.20
0.40
10.8
3.7
8.69
8.41
kpa
0.44
32
264
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
27.11
—
0
19
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
57
639
0.88
0.37
1.5
1.4
—
—
—
0
0
56
628
0.88
0.36
2.6
3.3
183.78
240.03
ng/l
0.64
49
581
63
565
1.12
0.36
2.1
2.8
—
—
—
0
0
41
469
0.87
0.36
1.3
1.4
—
—
—
0
0
66
731
0.89
0.35
1.5
1.6
—
—
—
0
0
75
681
1.11
0.35
2.2
3.3
67.39
66.42
g/l
0.52
66
631
28
330
0.84
0.35
1.0
1.2
—
31.22
—
0
9
6
86
0.70
0.33
1.7
1.3
—
—
—
0
0
6
90
0.66
0.33
1.3
1.2
—
—
—
0
0
32
370
0.86
0.33
2.7
4.3
1.02
1.02
ratio
0.06
26
346
23
273
0.84
0.32
1.4
1.2
0.30
1.73
u/ml
—
5
17
150
1588
0.93
0.31
2.2
1.8
1.52
1.34
mg/l
0.39
124
1256
14
175
0.80
0.31
1.1
1.4
—
—
—
0
0
336
3254
1.06
0.31
2.2
2.2
94.56
95.32
pmol/l
0.13
189
1704
7
54
1.30
0.30
1.3
1.1
—
—
—
0
0
32
367
0.87
0.30
2.5
2.4
—
—
—
0
0
16
196
0.81
0.30
1.6
1.6
—
—
—
0
0
15
185
0.81
0.30
2.0
1.8
33.93
40.97
nmol/l
0.96
15
175
674
6821
0.93
0.30
29.3
21.5
3.96
3.99
mmol/l
2.51
664
6678
237
2465
0.95
0.29
6.2
6.4
—
—
—
0
0
123
1306
0.93
0.28
2.8
2.6
12.49
12.56
umol/l
0.04
117
1224
36
407
0.88
0.28
1.6
1.8
—
—
—
0
0
38
338
1.13
0.27
2.5
2.1
—
—
—
0
0
5
71
0.70
0.26
1.2
1.8
—
—
—
0
0
674
6810
0.94
0.24
30.2
21.3
139.42
139.63
mmol/l
1.04
665
6679
9
76
1.19
0.24
1.8
1.3
568975.56
280112.02
e6/l
—
9
53
6
84
0.71
0.24
7.5
3.9
—
—
—
0
0
68
630
1.09
0.24
4.2
4.0
81.09
86.53
ng/l
0.26
55
549
73
679
1.08
0.23
2.2
2.4
34.68
105.67
u/l
0.49
59
561
15
179
0.83
0.23
1.1
1.2
—
—
—
0
0
7
93
0.75
0.22
1.3
1.4
7.84
6.75
mmol/l
—
7
88
5
40
1.25
0.22
1.0
1.8
—
—
—
0
0
17
199
0.85
0.22
1.5
1.6
—
—
—
0
0
5
42
1.19
0.21
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
5.96
—
0
11
0
11
0.00
0.21
0.0
3.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
10.80
—
0
5
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
17.67
—
0
10
0
12
0.00
0.21
0.0
2.3
—
37.58
—
0
12
0
12
0.00
0.21
0.0
1.8
—
1.97
—
0
12
0
12
0.00
0.21
0.0
4.7
—
9.75
—
0
12
0
12
0.00
0.21
0.0
1.0
—
17.29
—
0
7
19
219
0.86
0.20
1.2
1.4
327.91
289.16
ug/g
0.47
11
126
416
4082
1.04
0.20
9.6
9.9
4.57
4.19
e9/l
2.04
358
3542
0
14
0.00
0.20
0.0
1.2
—
920.00
—
0
5
86
910
0.94
0.20
1.6
1.5
—
—
—
0
0
17
197
0.86
0.20
1.5
1.6
—
—
—
0
0
516
5232
0.96
0.19
4.2
4.2
15.01
14.92
pmol/l
0.35
480
4735
237
2303
1.04
0.19
3.2
3.4
34.99
33.06
u/l
0.11
223
2177
90
949
0.94
0.19
2.0
2.9
1.88
1.80
%
0.30
80
857
7
58
1.21
0.18
1.4
2.2
42.07
39.89
%
—
7
58
16
184
0.87
0.17
1.5
1.7
—
—
—
0
0
8
69
1.16
0.16
1.0
1.1
—
—
—
0
0
117
1217
0.95
0.16
2.8
2.6
2.17
2.30
g/l
1.78
110
1135
8
72
1.11
0.16
1.0
1.1
—
—
—
0
0
6
76
0.79
0.15
7.2
3.4
60.83
57.02
%
—
6
69
9
78
1.16
0.15
1.0
1.1
—
—
—
0
0
224
2294
0.97
0.14
2.4
2.7
54.98
97.62
u/l
0.65
213
2125
27
295
0.91
0.14
1.6
1.9
19.00
8.06
iu/ml
—
7
72
10
84
1.19
0.14
1.4
1.2
—
—
—
0
0
33
305
1.09
0.14
2.5
2.9
—
—
—
0
0
8
98
0.81
0.13
1.3
1.2
0.50
19.07
nmol/l
—
8
92
11
94
1.17
0.13
1.5
1.7
—
—
—
0
0
538
5329
1.03
0.12
7.3
8.5
83.89
80.98
u/l
0.69
517
5035
12
105
1.14
0.11
1.0
1.1
0.02
1.08
u/ml
—
7
57
22
202
1.09
0.10
1.2
1.2
—
—
—
0
0
14
156
0.90
0.10
1.6
1.7
—
—
—
0
0
110
1132
0.97
0.10
3.0
2.6
23.73
22.21
%
0.42
105
1063
14
126
1.11
0.09
1.0
1.1
0.27
2.06
u/ml
—
8
71
27
288
0.94
0.09
1.5
1.5
0.34
0.29
mg/l
0.11
12
135
6
55
1.09
0.09
1.3
1.1
—
1.27
—
0
12
5
63
0.79
0.08
1.8
1.3
—
—
—
0
0
18
195
0.92
0.08
1.2
1.7
—
—
—
0
0
18
195
0.92
0.08
1.5
1.7
—
—
—
0
0
7
66
1.06
0.08
1.1
1.2
—
—
—
0
0
318
3215
0.98
0.08
2.4
2.6
78.18
77.78
nmol/l
0.09
295
2870
7
68
1.03
0.08
2.3
2.4
—
24.18
—
0
8
6
75
0.80
0.07
1.0
1.1
—
—
—
0
0
8
74
1.08
0.07
1.3
1.3
—
—
—
0
0
7
80
0.87
0.07
1.7
2.4
—
—
—
0
0
40
417
0.96
0.06
8.7
4.1
—
—
—
0
0
9
101
0.89
0.06
1.2
1.2
—
0.82
—
0
6
369
3660
1.01
0.06
6.0
6.4
0.04
0.04
e9/l
0.92
311
3121
12
109
1.10
0.06
1.0
1.1
0.07
1.84
u/ml
—
7
54
11
100
1.10
0.05
1.4
1.1
1.83
6.00
u/ml
—
6
41
367
3647
1.01
0.04
6.0
6.4
0.62
0.60
e9/l
0.55
309
3105
374
3718
1.01
0.04
6.3
6.5
1.89
1.92
e9/l
0.12
319
3258
201
2029
0.99
0.04
2.3
2.3
3.00
2.96
mg/l
0.08
179
1726
22
210
1.05
0.03
1.8
1.7
32889.21
14054.41
e6/l
0.43
14
153
56
571
0.98
0.03
7.8
4.1
7.41
7.41
ph
0.61
46
476
17
163
1.04
0.01
3.0
3.4
—
—
—
0
0
57
562
1.02
0.01
3.5
2.8
6.12
6.09
ph
0.09
38
386
34
347
0.98
0.01
2.3
2.3
0.00
2.41
estimate
0.50
14
104
14
146
0.96
0.00
1.2
1.1
—
—
—
0
0
17
176
0.97
0.00
2.2
1.8
1.97
4.86
iu/l
—
10
63
85
849
1.00
0.00
2.2
3.1
7.87
7.53
umol/l
0.04
71
752
0
6
0.00
0.00
0.0
1.3
—
80.67
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
4.56
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
60.44
—
0
9
0
9
0.00
0.00
0.0
2.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
287.18
—
0
5
0
5
0.00
0.00
0.0
1.0
—
0.06
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
-0.00
1.1
1.2
—
—
nmol/l
—
0
0
26
260
1.00
-0.00
2.5
4.0
3.08
4.10
ratio
0.22
16
154
0
8
0.00
-0.00
0.0
1.4
—
41.63
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
-0.00
1.7
2.8
2387.00
1122.87
mg
—
6
68
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
50
1.00
-0.00
2.6
1.9
7.56
6.85
mmol/l
—
5
35
5
50
1.00
-0.00
1.4
1.1
—
—
—
0
0
8
85
0.94
-0.00
1.5
1.9
89.30
89.65
%
—
8
85
8
80
1.00
-0.00
1.5
2.6
—
—
—
0
0
74
740
1.00
-0.00
2.1
2.8
74.38
68.34
e9/l
0.74
52
546
7
73
0.96
-0.00
2.4
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
-0.00
1.2
2.9
18.22
16.45
%
—
5
55
377
3770
1.00
-0.00
6.4
6.7
0.19
0.19
e9/l
0.05
326
3269
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HCCOMM and mortality.

Females

Parameter HR [95% CI] p-value
G6_HCCOMM 3.207 [2.83, 3.63] < 0.001
Birth year 0.997 [0.99, 1.01] 0.446

During the follow-up period (1.1.1998 — 31.12.2019), 862 out of 2207 females with G6_HCCOMM died.

Males

Parameter HR [95% CI] p-value
G6_HCCOMM 3.268 [2.82, 3.79] < 0.001
Birth year 0.988 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 835 out of 2089 males with G6_HCCOMM died.

Mortality risk

Mortality risk for people of age

years, who have G6_HCCOMM.

N-year risk Females Males
1 0.237% 0.734%
5 1.673% 3.6%
10 4.418% 9.74%
15 9.011% 17.976%
20 15.437% 29.439%

Relationships between endpoints

↥

Index endpoint: G6_HCCOMM – Communicating hydrocephalus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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