Lewy body dementia: A progressive form of dementia characterized by the presence of protein deposits called Lewy bodies in the midbrain and cerebral cortex, and loss of cholinergic and dopaminergic neurons. The signs and symptoms overlap with Alzheimer and Parkinson disease.
Other and unspecified degenerative diseases of nervous system
DOID EFO Endpoint Browser PheWeb
G6_DEGENOTH
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1204 |
4. Check minimum number of eventsNone |
1204 |
5. Include endpointsNone |
1204 |
6. Filter based on genotype QC (FinnGen only) |
1062 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEURODEG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified degenerative diseases of nervous system
based on the number of shared cases.
Similar with more cases:
- Degenerative diseases of the nervous system
- Other degenerative diseases of the nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10790 | 5168 | 5413 |
| Only index persons | 7351 | 3692 | 3659 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.15 | 0.15 |
| Only index persons | 0.14 | 0.14 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 74.25 | 75.65 | 72.93 |
| Only index persons | 74.27 | 75.65 | 72.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1062 | 439 | 623 |
| Unadjusted period prevalence (%) | 0.23 | 0.16 | 0.29 |
| Median age at first event (years) | 74.39 | 75.10 | 73.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1092
- Matched controls
- 10920
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
15.8
311.9
304
261
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
2470.1
307.7
335
*
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
4793.3
307.7
698
*
N06DA03
ATC
rivastigmine; oral, transdermal
32.5
307.7
359
162
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
7.6
205.8
372
693
N05AH04
ATC
quetiapine; oral
6.8
193.1
401
855
G30.8
ICD-10 Finland
Other Alzheimer disease
57.5
192.6
109
21
N06DX01
ATC
memantine; oral
11.1
190.0
224
249
N05AX08
ATC
risperidone; systemic
8.5
183.1
275
414
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
25.6
158.7
113
49
F03
ICD-10 Finland
Unspecified dementia
8.8
154.5
217
299
G30.1
ICD-10 Finland
Alzheimer disease with late onset
16.0
148.3
132
93
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
62.8
136.6
76
13
N06DA02
ATC
donepezil; oral
9.4
130.2
168
207
G20
ICD-10 Finland
Parkinson disease
8.8
127.8
175
232
P20
ICPC
Memory disturbance
4.6
120.3
388
1159
TAB00
NOMESCO Finland
Lumbar puncture
9.3
113.3
145
176
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
8.3
108.9
154
211
XA800
NOMESCO Finland
Neuropsychological investigation
9.5
98.2
122
142
A28
ICPC
Limited function/disability NOS
3.5
83.6
442
1791
N05AH03
ATC
olanzapine; systemic
7.1
77.3
124
194
P70
ICPC
Dementia
10.4
76.1
87
90
G31.0
ICD-10 Finland
Circumscribed brain atrophy
201.1
73.1
75
*
R44.1
ICD-10 Finland
Visual hallucinations
21.4
70.1
53
26
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.4
67.1
194
514
N87
ICPC
Parkinsonism
8.9
63.7
82
99
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
60.2
413
1881
F05.1
ICD-10 Finland
Delirium superimposed on dementia
21.8
56.1
42
20
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.3
55.6
162
429
R41.3
ICD-10 Finland
Other amnesia
6.4
55.2
95
159
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
12.0
54.6
56
49
AA1AD
NOMESCO Finland
CT of head and brain
2.7
54.2
516
2748
N99
ICPC
Neurological disease other
10.9
53.9
59
57
F06.7
ICD-10 Finland
Mild cognitive disorder
5.6
51.3
102
196
F05.9
ICD-10 Finland
Delirium, unspecified
6.4
51.2
88
147
R53
ICD-10 Finland
Malaise and fatigue
2.7
49.9
394
1897
R41.0
ICD-10 Finland
Disorientation, unspecified
5.5
48.5
99
195
N05BA04
ATC
oxazepam; oral
2.7
48.5
381
1826
N03AG01
ATC
valproic acid; systemic, rectal
4.9
46.0
107
236
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.5
45.4
498
2775
L28
ICPC
Limited function/disability (L)
2.6
45.1
365
1764
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.2
42.6
122
317
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
8.1
42.4
58
75
N29
ICPC
Neurological sympt/complt other
7.5
41.9
61
85
N28
ICPC
Limited function/disability (N)
7.2
39.7
60
87
R27.0
ICD-10 Finland
Ataxia, unspecified
15.9
39.3
34
22
SPAT1216
SPAT
Assessment of functional ability
2.5
36.8
292
1379
N03AE01
ATC
clonazepam; systemic
4.1
36.7
109
290
SPAT1053
SPAT
Memory test
2.5
34.9
270
1256
N05BA06
ATC
lorazepam; systemic, sublingual
3.7
31.6
107
312
G30.0
ICD-10 Finland
Alzheimer disease with early onset
164.7
30.8
32
*
N06AB10
ATC
escitalopram; oral
2.6
30.8
214
941
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
9.8
30.7
36
38
N05AD01
ATC
haloperidol; systemic
4.8
30.7
72
159
F0280, G318,
ICD-10 Finland
+∞
30.3
29
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.7
30.2
100
287
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.8
29.9
168
663
N06AX11
ATC
mirtazapine; oral
2.1
28.7
415
2475
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
4.9
28.6
65
140
R1250
NOMESCO Finland
Evaluation of functional capability
5.6
28.3
55
103
I95.1
ICD-10 Finland
Orthostatic hypotension
3.4
27.3
103
322
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
6.6
27.1
44
69
F29
ICD-10 Finland
Unspecified nonorganic psychosis
5.6
26.4
51
95
3319X
ICD-9 Finland
Other cerebral degenerations, Cerebral degeneration, unspecified
+∞
26.1
25
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.2
25.8
111
376
A04
ICPC
Weakness/tiredness general
2.3
25.7
233
1149
R25.1
ICD-10 Finland
Tremor, unspecified
4.5
25.4
64
150
F02.80
ICD-10 Finland
Dementia in another specified disease that is classified elsewhere without additional symptoms
+∞
25.1
24
*
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.8
25.0
136
525
H02AA02
ATC
fludrocortisone; oral
8.6
25.0
32
38
N05AX12
ATC
aripiprazole; systemic
6.7
24.9
40
62
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.0
24.8
119
429
A06AD11
ATC
lactulose; oral
2.2
23.9
266
1421
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.2
23.6
65
163
N19
ICPC
Speech disorder
6.1
23.5
41
69
N06DA04
ATC
galantamine; oral
5.6
23.0
44
81
XF606
NOMESCO Finland
Ortostatic test
9.5
22.7
27
29
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
53.2
22.2
26
5
IGY02
NOMESCO Finland
Psychiatric monitoring contact
6.0
21.9
39
67
Z2445
NOMESCO Finland
Psychologist
4.8
21.9
50
108
N03AX14
ATC
levetiracetam; systemic
4.6
21.4
51
114
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
21.2
239
1277
F0289, G318,
ICD-10 Finland
+∞
20.9
20
*
F02.09*G31.0
ICD-10 Finland
Dementia in Pick's disease without information on additional symptoms
+∞
20.9
20
*
SPAT1234
SPAT
Support of social functional capacity
2.9
20.6
101
368
N02AA05
ATC
oxycodone; systemic
2.0
20.5
302
1776
D21
ICPC
Swallowing problem
5.4
20.4
41
79
N06AX26
ATC
vortioxetine; oral
3.4
20.3
77
241
G04BD12
ATC
mirabegron; oral
2.2
19.9
198
1005
S01.0
ICD-10 Finland
Open wound of scalp
2.5
19.8
134
575
WYA20
NOMESCO Finland
Home visit
4.6
19.8
48
109
N06AB04
ATC
citalopram; systemic
2.0
19.7
245
1355
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.4
19.7
50
118
AA5EN
NOMESCO Finland
Brain reseptor or transprot protein distribution isotope imaging
25.1
19.6
27
11
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.1
19.6
83
278
N05AD03
ATC
melperone; systemic
5.8
19.5
36
64
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.1
19.1
85
293
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.2
18.9
77
252
R5110, ,
SPAT
2.4
18.8
143
647
F0282, G318,
ICD-10 Finland
+∞
18.8
18
*
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
5.3
18.7
38
74
S06.0
ICD-10 Finland
Concussion
2.3
18.7
149
689
R4130
NOMESCO Finland
Speech therapy
4.2
18.6
50
123
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.5
18.0
117
492
F0029, G308,
ICD-10 Finland
+∞
17.8
17
*
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.4
17.8
137
624
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
17.7
399
2663
G31.1
ICD-10 Finland
Senile degeneration of brain, not elsewhere classified
96.6
17.6
19
*
G23.8
ICD-10 Finland
Other specified degenerative diseases of basal ganglia
42.7
17.3
21
5
N04BD01
ATC
selegiline; oral
4.8
16.9
38
81
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
6.6
16.7
27
42
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
5.7
16.6
31
56
SPAT1229
SPAT
Assessment of need for aid
2.4
16.3
124
560
M03BX01
ATC
baclofen; systemic
4.6
16.0
38
85
F0019, G301,
ICD-10 Finland
+∞
15.7
15
*
K59.09
ICD-10 Finland
Constipation, unspecified
2.4
15.6
113
499
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
3.6
15.4
51
146
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
4.3
15.4
40
96
P29
ICPC
Psychological sympt/compl other
3.2
15.3
62
202
N30.0
ICD-10 Finland
Acute cystitis
2.0
15.1
202
1137
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
14.7
165
2848
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
5.0
14.6
31
63
R42
ICD-10 Finland
Dizziness and giddiness
1.8
14.5
306
1981
AA5DR
NOMESCO Finland
Brain metabolism PET with CT
152.0
14.5
15
*
F06.0
ICD-10 Finland
Organic hallucinosis
19.4
14.3
21
11
U04
ICPC
Incontinence urine
2.4
14.2
99
430
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
14.1
221
1308
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.7
14.0
75
286
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.5
13.9
93
396
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.4
13.8
49
147
3318X
ICD-9 Finland
Other cerebral degenerations, Other cerebral degeneration
+∞
13.6
13
*
AXX01
NOMESCO Finland
Memory assessment
11.1
13.5
25
23
F02.8
ICD-10 Finland
Dementia in other specified diseases classified elsewhere
141.7
13.5
14
*
IBZ07
NOMESCO Finland
Neurological assessment in psychiatry
26.1
13.4
18
7
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
2.0
13.4
158
849
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
4.8
13.4
30
64
AXX01, ,
SPAT
2.7
13.3
74
288
W19
ICD-10 Finland
Unspecified fall
2.1
13.2
132
666
F22.0
ICD-10 Finland
Delusional disorder
5.7
12.9
24
43
A29
ICPC
General symptom/complaint other
1.9
12.7
180
1028
G11.9
ICD-10 Finland
Hereditary ataxia, unspecified
17.6
12.5
19
11
S72.0
ICD-10 Finland
Fracture of neck of femur
2.5
12.3
82
349
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
10.2
12.0
23
23
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
4.9
11.9
26
54
R35
ICD-10 Finland
Polyuria
2.2
11.9
105
504
N04BC04
ATC
ropinirole; oral
5.4
11.9
23
43
N04BD02
ATC
rasagiline; oral
5.9
11.8
21
36
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
5.6
11.7
22
40
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
4.4
11.5
29
68
F02.84
ICD-10 Finland
Dementia in another specified disease that is classified elsewhere as other mixed symptoms of mixed type
+∞
11.5
11
*
G32.0*E53.8
ICD-10 Finland
Subacute combined degeneration of the spinal cord in case of vitamin B12 deficiency
+∞
11.5
11
*
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
35.4
11.3
14
*
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
5.3
11.1
22
42
SPAT1254
SPAT
Administration of medicine
1.8
11.0
194
1182
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.2
10.9
42
133
Z75.5
ICD-10 Finland
Holiday relief care
5.2
10.8
22
43
SPAT1231
SPAT
Assessment of adjustments needed in living environment
3.3
10.6
39
120
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
5.3
10.6
21
40
F02.82
ICD-10 Finland
Dementia in other specified disease that is classified elsewhere other symptoms, mainly hallucinations
111.1
10.4
11
*
F009, G309,
ICD-10 Finland
111.1
10.4
11
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
10.4
202
1265
F05.8
ICD-10 Finland
Other delirium
5.2
10.3
21
41
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.8
10.3
51
187
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
10.2
186
1143
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
7.6
10.2
23
31
ZXY02
NOMESCO Finland
Neuropsychologist
14.7
10.0
16
11
N05BE01
ATC
buspirone; oral
3.4
9.9
35
105
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
16.9
9.9
15
9
F02.89
ICD-10 Finland
Dementia in another specified disease that is classified elsewhere without information of additional symptoms
26.3
9.8
13
5
XQ855, ,
SPAT
4.8
9.8
22
47
N06AB06
ATC
sertraline; oral
2.1
9.8
95
474
N04BC05
ATC
pramipexole; oral
2.0
9.7
106
552
N03AX09
ATC
lamotrigine; oral
3.1
9.7
39
127
R44.3
ICD-10 Finland
Hallucinations, unspecified
7.9
9.6
21
27
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.5
9.4
60
250
G71.3
ICD-10 Finland
Mitochondrial myopathy, not elsewhere classified
+∞
9.4
9
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.6
9.3
30
85
N06AX16
ATC
venlafaxine; oral
1.9
9.2
116
636
N05AN01
ATC
lithium; oral
4.0
9.2
26
67
R55
ICD-10 Finland
Syncope and collapse
1.8
9.1
149
887
N04AA02
ATC
biperiden; systemic
4.0
9.1
25
63
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.6
9.1
54
218
N05BA01
ATC
diazepam; systemic, rectal
1.8
9.1
150
895
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
4.1
9.0
24
59
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
2.6
9.0
53
213
G11.2
ICD-10 Finland
Late-onset cerebellar ataxia
24.2
8.9
12
5
G93.4
ICD-10 Finland
Encephalopathy, unspecified
12.7
8.9
15
12
N06AX21
ATC
duloxetine; oral
1.9
8.8
113
623
F06.9
ICD-10 Finland
Unspecified mental disorder due to brain damage and dysfunction and to physical disease
14.2
8.7
14
10
N05AH02
ATC
clozapine; systemic
6.5
8.5
21
33
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
20.2
8.5
12
6
Z31.5
ICD-10 Finland
Genetic counselling
2.9
8.4
39
138
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
3.5
8.4
28
81
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
8.4
91
473
R4130, ,
SPAT
12.9
8.4
14
11
F028, G318,
ICD-10 Finland
+∞
8.3
8
*
N05AF03
ATC
chlorprothixene; systemic
3.7
8.3
26
72
S01.8
ICD-10 Finland
Open wound of other parts of head
3.7
8.3
26
72
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
3.5
8.3
28
82
R47.1
ICD-10 Finland
Dysarthria and anarthria
4.0
8.2
23
59
G72.8
ICD-10 Finland
Other specified myopathies
3.2
8.1
31
98
N05AB03
ATC
perphenazine; systemic, rectal
2.9
8.1
38
136
N80
ICPC
Head injury other
3.1
8.1
33
109
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.7
8.1
153
949
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
8.0
189
1243
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
7.8
7.9
17
22
OAB41
NOMESCO Finland
Guidance and counselling related to ageing
8.5
7.8
16
19
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.9
7.8
108
610
L89
ICD-10 Finland
Decubitus ulcer and pressure area
2.9
7.8
35
122
N05AA02
ATC
levomepromazine; systemic
2.6
7.7
45
180
N02BE01
ATC
paracetamol; systemic, rectal
1.6
7.6
922
8410
F00
ICD-10 Finland
Dementia in Alzheimer disease
11.9
7.6
13
11
N03AX18
ATC
lacosamide; systemic
8.9
7.6
15
17
G30
ICD-10 Finland
Alzheimer disease
8.9
7.6
15
17
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
4.3
7.5
19
45
R32
ICD-10 Finland
Unspecified urinary incontinence
2.7
7.5
38
142
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
3.2
7.4
28
88
G32
ICD-10 Finland
Other degenerative disorders of nervous system in diseases classified elsewhere
80.6
7.4
8
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.5
7.4
45
184
SPAT1360
SPAT
Extensive global examination
2.0
7.3
75
382
F0284, G318,
ICD-10 Finland
+∞
7.3
7
*
G32.8
ICD-10 Finland
Other specified degenerative disorders of nervous system in diseases classified elsewhere
+∞
7.3
7
*
N05BA12
ATC
alprazolam; oral
1.9
7.3
99
556
R60.0
ICD-10 Finland
Localized oedema
1.7
7.2
156
1000
G21.8
ICD-10 Finland
Other secondary parkinsonism
15.9
7.2
11
7
N05CF01
ATC
zopiclone; oral
1.4
7.2
363
2798
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
7.1
126
766
SPAT1101
SPAT
Orthostatic test
2.2
7.1
61
291
OAB48
NOMESCO Finland
Lifestyle advice and guidance
12.1
7.1
12
10
K03.66
ICD-10 Finland
Tooth plaque
2.0
7.1
80
423
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
2.9
7.1
33
118
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.8
7.0
112
661
N03AF02
ATC
oxcarbazepine; oral
2.7
7.0
35
130
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.1
6.9
61
294
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.3
6.9
25
77
N17
ICPC
Vertigo/dizziness
1.6
6.7
151
977
130
Kela drug reimbursment
Malignant tumour
0.4
6.7
35
816
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.5
6.6
195
1346
J01EA01
ATC
trimethoprim; systemic
1.5
6.6
268
1978
G23.1
ICD-10 Finland
Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
12.3
6.6
11
9
R26.0
ICD-10 Finland
Ataxic gait
8.8
6.6
13
15
Z02.7
ICD-10 Finland
Issue of medical certificate
1.9
6.4
80
437
S00.0
ICD-10 Finland
Superficial injury of scalp
2.6
6.4
36
142
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
6.4
177
1204
R1100, ,
SPAT
3.8
6.4
19
51
WYA20, ,
SPAT
5.2
6.3
18
35
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
11.1
6.3
11
10
F02.81
ICD-10 Finland
Dementia in another specified disease that is classified elsewhere as additional symptoms, mainly paranoidism
+∞
6.3
6
*
S01.41
ICD-10 Finland
Open wound in the temple-jaw region
4.0
6.2
17
43
SPAT1167
SPAT
Insertion of urinary catheter
2.2
6.2
53
253
XCK00
NOMESCO Finland
Perimetry
1.9
6.2
77
421
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
6.2
223
1606
N05CD07
ATC
temazepam; oral
1.6
6.2
155
1031
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
5.4
6.2
17
32
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
0.2
6.2
6
296
R63.4
ICD-10 Finland
Abnormal weight loss
2.2
6.1
52
247
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.6
6.1
146
961
R54
ICD-10 Finland
Senility
6.7
6.0
14
21
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
6.7
6.0
14
21
ZY000
NOMESCO Finland
Hospital inpatient
5.6
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
114
51
24.84
158.18
1.1
1.1
756.60
765.18
ng/l
0.04
94
28
114
51
24.84
158.18
1.1
1.1
282.70
233.11
ng/l
0.85
97
27
114
51
24.84
158.18
1.1
1.1
35.18
32.06
ng/l
0.24
97
26
139
161
9.75
112.58
1.2
1.2
3.89
3.84
mmol/l
0.18
134
150
131
169
8.67
97.14
1.4
1.3
220.35
839.75
e6/l
0.45
97
132
128
167
8.55
93.97
1.4
1.3
4.01
61.20
e6/l
0.90
88
126
64
73
9.25
51.83
1.1
1.0
—
—
—
0
0
60
65
9.71
50.50
1.1
1.0
—
—
—
0
0
55
57
10.11
47.78
1.1
1.0
—
—
—
0
0
364
1959
2.29
33.72
1.9
1.8
1086.29
1180.50
nmol/l
1.09
288
1465
57
96
6.21
32.74
5.8
4.7
332.21
343.06
umol/l
0.18
47
85
53
83
6.66
32.66
1.4
1.2
—
—
—
0
0
40
45
9.19
32.61
1.3
1.1
47.49
49.17
mg/l
0.04
35
40
38
42
9.34
31.38
1.3
1.0
—
—
—
0
0
35
36
10.01
30.45
1.2
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
33
35
9.69
28.06
1.2
1.1
—
—
—
0
0
650
4595
2.02
27.66
2.7
2.3
92.93
94.19
pmol/l
0.29
373
2416
489
3194
1.96
25.43
2.0
1.8
20.27
19.85
nmol/l
0.25
431
2649
481
3154
1.94
24.45
3.0
2.3
247.96
231.96
u/l
0.14
459
2979
29
32
9.28
23.92
1.3
1.1
0.49
0.49
ratio
0.04
17
18
335
1966
2.02
23.29
2.2
2.0
—
—
—
0
0
251
1390
2.05
20.11
2.1
1.9
—
—
—
0
0
264
1492
2.01
19.98
2.1
1.8
—
—
—
0
0
27
35
7.88
19.61
1.5
1.1
—
—
—
0
0
70
224
3.27
17.81
2.3
2.8
24.51
35.65
umol/l
4.52
61
197
619
4675
1.75
17.76
6.0
6.9
1.22
1.21
mmol/l
2.99
573
4298
672
5206
1.76
17.51
7.1
7.7
1.22
1.21
mmol/l
4.44
594
4478
25
39
6.54
15.42
1.1
1.0
1.01
1.13
u/l
—
10
19
592
4589
1.63
13.94
4.5
5.4
34.86
34.48
g/l
1.01
548
4284
146
767
2.04
13.15
1.9
1.7
—
—
—
0
0
526
4012
1.60
12.85
2.6
2.4
76.90
79.70
nmol/l
1.27
454
3496
23
20
11.72
12.84
1.2
1.1
—
—
—
0
0
136
702
2.07
12.83
1.9
1.7
1.62
1.60
%
0.11
117
570
744
6230
1.61
11.72
7.5
5.4
38.00
2013.85
e6/l
—
10
106
105
512
2.16
11.47
2.7
2.6
17.83
20.91
au/ml
—
7
36
459
3467
1.56
11.20
2.8
3.7
2.35
2.35
mmol/l
0.01
408
3100
21
38
5.62
11.20
1.2
1.1
—
—
—
0
0
111
584
2.00
9.90
1.7
1.5
—
—
—
0
0
302
2174
1.54
8.69
2.7
3.2
2.46
2.47
mmol/l
0.15
269
1923
17
20
8.62
8.32
1.2
1.1
—
—
—
0
0
23
59
3.96
8.18
2.3
2.4
—
—
—
0
0
17
21
8.20
8.10
1.2
1.0
—
—
—
0
0
255
3472
0.65
7.96
1.8
2.0
1.15
1.30
mmol/l
4.37
224
2813
17
22
7.83
7.89
1.1
1.0
—
—
—
0
0
17
22
7.83
7.89
1.2
1.0
—
—
—
0
0
17
23
7.49
7.69
1.2
1.0
—
—
—
0
0
15
17
8.93
7.55
1.1
1.1
—
—
—
0
0
298
2201
1.49
7.42
1.7
1.8
462.04
19643293.22
pmol/l
1.44
246
1792
19
32
6.02
7.39
1.1
1.2
—
—
—
0
0
13
14
9.38
6.79
1.0
1.1
—
—
—
0
0
371
2899
1.42
6.75
2.3
2.4
2.65
3.03
mg/l
2.39
311
2474
11
9
12.33
6.59
1.0
1.1
—
—
—
0
0
256
1885
1.47
6.35
4.0
3.3
1.42
1.26
e6/l
0.19
125
1067
11
10
11.10
6.30
1.1
1.1
—
—
—
0
0
11
10
11.10
6.30
1.1
1.1
—
—
—
0
0
241
1756
1.48
6.30
4.1
3.4
2.87
1.86
e6/l
0.49
107
936
10
8
12.60
6.09
1.1
1.0
—
—
—
0
0
12
14
8.65
6.06
1.0
1.1
—
—
—
0
0
276
2092
1.43
5.81
5.7
4.7
1.01
1.02
kg/l
0.45
199
1435
566
4835
1.35
5.70
4.9
4.4
0.03
2.90
estimate
0.79
92
1108
479
4006
1.35
5.47
2.8
2.4
—
—
—
0
0
567
4872
1.34
5.36
5.0
4.4
0.13
0.29
estimate
0.23
84
1035
713
6356
1.35
5.18
4.4
4.1
15.41
15.11
pmol/l
2.18
642
5691
656
5781
1.34
5.12
7.1
5.5
6.83
6.84
mmol/l
0.05
630
5532
236
1786
1.41
4.93
2.7
3.2
0.81
0.82
mmol/l
0.64
218
1674
12
20
6.05
4.92
1.8
2.2
—
—
—
0
0
69
395
1.80
4.84
2.1
1.8
—
—
—
0
0
553
4779
1.32
4.83
4.9
4.4
0.00
0.00
estimate
-0.00
90
1081
12
21
5.76
4.76
1.9
2.2
—
—
—
0
0
227
1730
1.39
4.53
1.3
1.2
0.93
1.45
u/ml
1.06
45
429
72
427
1.73
4.49
2.1
2.3
329.79
616.49
ug/l
0.79
66
406
0
112
0.00
4.39
0.0
1.3
—
1.51
—
0
112
13
28
4.69
4.37
2.4
1.6
68.07
49.87
ug/l
0.52
13
28
589
5194
1.29
4.18
4.0
3.4
51.68
57.27
u/l
0.77
533
4783
13
30
4.37
4.13
1.2
1.4
102.50
126.82
nmol/l
—
6
22
126
875
1.50
4.13
1.9
2.2
423.09
384.60
nmol/l
0.99
117
805
7
7
10.05
4.01
1.3
1.1
—
—
—
0
0
262
2102
1.32
3.70
4.5
4.4
219.86
308.33
ng/l
0.34
237
1829
141
1026
1.43
3.64
2.1
2.2
0.20
0.20
g/l
0.01
125
949
44
244
1.84
3.49
1.4
1.3
—
—
—
0
0
44
244
1.84
3.49
1.4
1.3
—
—
—
0
0
92
1315
0.67
3.32
1.2
1.3
11.53
14.71
u/ml
0.16
27
464
354
2993
1.27
3.31
4.4
3.6
0.35
0.50
e6/l
1.31
238
2290
402
3457
1.26
3.24
4.4
3.7
71.19
99.01
e6/l
0.41
281
2725
33
171
1.96
3.22
1.1
1.1
—
8.88
—
0
12
67
429
1.60
3.20
2.2
2.0
—
—
—
0
0
136
1012
1.39
3.11
2.8
3.2
152.87
263.11
ng/l
6.26
127
938
358
3058
1.25
3.02
2.5
2.7
55.52
89.67
u/l
0.71
326
2818
747
7984
0.80
3.00
23.1
20.3
76.69
72.05
ml/min/173m2
8.36
687
7498
140
1059
1.37
2.91
5.4
7.3
1.47
1.38
mmol/l
0.40
134
1044
819
7684
1.26
2.83
6.0
5.3
1.87
2.06
mu/l
3.96
743
6934
25
124
2.04
2.77
1.3
1.4
280.53
275.16
mosm/kgh2o
0.29
17
92
23
111
2.10
2.74
1.1
1.8
—
—
—
0
0
6
10
6.03
2.70
1.2
1.1
105.33
87.10
%
—
6
10
300
3501
0.80
2.68
3.5
3.5
6.62
7.15
mmol/l
1.49
247
2901
48
298
1.64
2.63
1.7
1.5
239.69
271.74
ug/g
0.46
28
186
138
1059
1.35
2.62
1.9
2.9
65.90
65.77
g/l
0.07
123
975
308
3574
0.81
2.59
4.2
4.3
6.47
10.49
mg/mmol
1.55
186
2292
215
2594
0.79
2.55
2.6
3.1
351.91
363.62
umol/l
0.86
173
2228
563
5109
1.21
2.54
19.1
19.7
1.36
1.36
inr
0.04
483
4325
755
7055
1.23
2.51
7.5
8.8
77.48
82.42
u/l
3.02
704
6651
106
1402
0.73
2.47
1.2
1.3
29.51
37.95
iu/ml
0.39
28
435
110
826
1.37
2.41
1.8
1.7
—
—
—
0
0
5
8
6.27
2.37
1.0
1.0
—
—
—
0
0
21
105
2.02
2.32
1.1
1.9
—
—
—
0
0
754
7975
0.82
2.27
4.8
5.4
1.45
1.43
mmol/l
0.70
676
7181
69
485
1.45
2.22
2.1
2.5
2.84
3.02
g/l
0.85
58
437
762
8037
0.83
2.14
4.8
5.5
4.34
4.37
mmol/l
0.36
681
7303
56
381
1.50
2.12
1.4
1.3
—
—
—
0
0
93
1225
0.74
2.12
3.2
4.2
30.67
24.22
ug/l
0.11
77
1038
5
10
5.02
2.07
1.4
1.0
—
—
—
0
0
5
10
5.02
2.07
1.4
1.0
—
—
—
0
0
705
6603
1.19
2.04
4.4
4.6
12.79
14.78
mm/h
3.07
638
6090
43
279
1.56
2.03
1.5
1.7
0.25
0.31
mg/l
0.32
20
119
65
461
1.44
2.01
2.2
2.6
9.18
10.69
g/l
2.09
54
412
783
8219
0.83
1.97
5.7
6.4
2.45
2.49
mmol/l
0.55
701
7433
10
39
2.58
1.94
2.0
1.4
—
—
—
0
0
562
5179
1.18
1.93
4.6
6.9
11.69
12.56
umol/l
1.58
530
4952
28
456
0.60
1.91
2.1
3.5
16.82
9266.88
u/ml
0.91
22
396
148
1206
1.26
1.84
3.3
3.6
1.94
1.93
mmol/l
0.02
138
1015
729
7669
0.85
1.73
4.1
4.6
1.19
1.27
mmol/l
2.45
643
6841
62
450
1.40
1.73
2.2
2.7
1.26
1.43
g/l
0.08
51
384
44
299
1.49
1.72
3.4
3.8
5.65
1.71
index
1.03
14
161
22
370
0.59
1.72
1.4
3.4
37.91
114.59
u/ml
1.24
22
361
442
4031
1.16
1.66
3.0
3.1
138.26
151.99
ug/l
0.64
406
3664
167
1401
1.23
1.62
5.9
7.6
1.16
0.89
mmol/l
0.34
137
1144
70
525
1.36
1.62
2.1
2.5
3.80
3.67
g/l
0.29
59
477
16
288
0.55
1.61
1.4
1.3
—
—
—
0
0
440
4018
1.16
1.61
4.9
4.6
25.63
89.94
ng/l
2.29
362
3234
70
526
1.35
1.60
2.1
2.5
4.19
4.13
g/l
0.22
59
478
70
526
1.35
1.60
2.1
2.5
7.41
7.49
g/l
0.15
59
477
85
659
1.31
1.58
3.7
4.0
1.55
1.95
mmol/l
0.37
68
488
204
2358
0.83
1.56
3.4
3.6
0.82
0.82
ug/l
0.00
154
1695
167
1412
1.22
1.51
5.9
7.5
5.05
5.10
kpa
0.26
160
1358
223
1938
1.19
1.50
2.3
2.7
11.96
11.90
umol/l
0.05
208
1812
167
1413
1.21
1.50
5.9
7.5
11.33
11.96
kpa
0.86
158
1362
323
2898
1.16
1.48
3.1
3.2
29.20
35.61
u/l
3.88
300
2732
9
38
2.38
1.45
1.2
1.1
—
—
—
0
0
113
921
1.25
1.44
2.0
2.6
30.13
35.89
u/l
0.96
92
766
14
75
1.88
1.34
1.2
1.3
—
—
—
0
0
14
75
1.88
1.34
1.2
1.3
—
—
—
0
0
10
47
2.14
1.34
2.6
2.2
207.90
255.10
e6/l
—
10
42
10
47
2.14
1.34
2.3
2.1
232.80
671.74
e6/l
—
10
38
387
3541
1.14
1.33
5.5
4.6
0.00
0.06
estimate
1.31
77
888
18
106
1.71
1.30
1.5
1.1
31.33
19.62
iu/ml
—
6
21
69
540
1.30
1.24
4.5
5.4
1.50
1.54
%
0.22
64
510
41
558
0.72
1.23
2.2
1.8
6.39
2.16
ug/l
0.75
33
485
95
776
1.25
1.22
3.7
4.0
5.15
5.14
kpa
0.02
89
743
17
102
1.68
1.16
1.6
1.5
—
—
—
0
0
136
1160
1.20
1.15
10.3
8.8
—
—
—
0
0
782
8100
0.88
1.15
5.6
5.8
6.16
6.12
mmol/l
0.36
699
7260
49
370
1.34
1.14
2.6
2.6
0.00
0.00
g/l
-0.00
43
326
90
738
1.24
1.13
5.6
7.0
24.65
24.24
mmol/l
0.46
85
708
277
2505
1.14
1.12
4.2
4.4
82.49
83.35
%
0.21
268
2462
58
737
0.78
1.10
1.6
1.4
—
—
—
0
0
43
321
1.35
1.09
1.0
1.1
—
—
—
0
0
554
5234
1.12
1.08
7.7
9.5
4.65
4.28
e9/l
2.12
452
4498
14
230
0.60
1.08
1.1
1.3
—
—
—
0
0
858
8321
1.15
1.07
24.6
20.3
28.42
28.33
mg/l
0.03
789
7109
771
7979
0.89
1.06
7.5
7.5
40.20
40.54
mmol/mol
0.47
697
7326
39
289
1.36
1.04
1.3
1.6
—
—
—
0
0
38
281
1.37
1.03
1.3
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
31
425
0.72
1.01
2.2
2.6
0.33
0.36
iu/ml
0.22
15
240
58
724
0.79
0.98
1.3
1.4
—
—
—
0
0
20
132
1.52
0.97
1.5
1.4
—
—
—
0
0
170
1502
1.16
0.96
4.3
5.6
1.01
1.05
mmol/l
0.88
157
1388
18
270
0.66
0.95
2.3
1.5
—
—
—
0
0
9
52
1.74
0.92
2.7
2.1
—
—
—
0
0
675
6481
1.11
0.92
32.7
27.1
331.63
331.02
g/l
1.09
669
6443
5
101
0.49
0.89
2.4
1.4
—
—
—
0
0
144
1265
1.16
0.89
6.0
7.9
94.18
95.30
%
0.90
139
1226
200
1801
1.14
0.87
2.3
2.6
2.22
2.23
g/l
0.15
187
1668
6
30
2.01
0.87
2.8
3.4
24.67
32.27
umol/l
—
6
24
17
112
1.53
0.85
4.6
3.5
14.38
11.60
index
—
8
60
6
31
1.94
0.84
1.5
1.0
1348.50
1500.35
miu/ml
—
6
31
120
1049
1.16
0.81
2.6
2.9
4.34
4.45
kpa
0.28
115
1019
19
270
0.70
0.79
1.4
2.4
3.53
3.65
g/l
0.19
19
255
99
857
1.17
0.76
3.4
3.8
91.86
99.11
ng/l
0.34
85
729
28
210
1.34
0.74
1.2
1.2
—
—
—
0
0
41
325
1.27
0.74
3.5
3.8
3.86
3.97
mmol/l
1.03
41
320
16
108
1.49
0.73
1.2
1.6
18.21
36.84
ng/l
1.02
16
108
7
38
1.85
0.73
1.0
2.8
—
49632.11
—
0
9
24
176
1.37
0.73
1.9
1.7
2.94
4.91
iu/l
1.56
11
67
31
237
1.32
0.73
1.5
1.4
—
—
—
0
0
9
56
1.61
0.72
1.2
1.3
—
—
—
0
0
9
56
1.61
0.72
1.2
1.3
—
—
—
0
0
18
126
1.44
0.70
1.4
1.5
—
—
—
0
0
18
126
1.44
0.70
1.4
1.5
—
—
—
0
0
7
41
1.71
0.70
2.3
2.2
697.43
1323.10
u/ml
—
7
41
36
284
1.28
0.69
1.4
1.3
—
—
—
0
0
18
127
1.42
0.68
1.4
1.5
—
—
—
0
0
186
1697
1.12
0.68
2.4
2.7
21.06
21.65
%
0.31
174
1591
24
180
1.34
0.65
1.2
1.3
—
—
—
0
0
50
414
1.22
0.64
3.4
3.4
4.41
4.34
pmol/l
0.25
45
367
17
233
0.73
0.61
1.5
2.3
211.59
209.95
%
0.02
17
220
8
50
1.60
0.61
1.0
1.1
—
—
—
0
0
9
140
0.64
0.60
1.3
1.3
—
—
—
0
0
10
151
0.66
0.60
1.3
1.4
186.00
284.29
u/l
—
10
145
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
13
185
0.70
0.58
2.3
1.8
1.92
1.68
mmol/l
0.30
13
179
0
23
0.00
0.58
0.0
1.3
—
11.52
—
0
23
18
132
1.37
0.57
1.5
1.4
—
—
—
0
0
25
319
0.78
0.57
1.2
1.6
—
—
—
0
0
16
115
1.40
0.56
1.5
1.5
—
—
—
0
0
8
55
1.46
0.56
1.5
2.2
—
—
—
0
0
8
55
1.46
0.56
1.5
1.5
94.88
90.22
umol/l
—
8
55
48
404
1.20
0.54
1.1
1.2
214.10
139.02
u/ml
0.42
18
142
8
126
0.63
0.54
3.9
3.9
—
—
—
0
0
26
204
1.28
0.54
1.2
1.5
—
—
—
0
0
6
39
1.54
0.53
1.5
1.1
—
—
—
0
0
65
743
0.87
0.50
2.2
2.4
13.58
12.63
nmol/l
0.36
58
649
9
65
1.39
0.50
1.3
1.2
—
—
—
0
0
11
76
1.45
0.48
1.1
1.2
100.18
97.16
pmol/l
0.11
11
76
37
309
1.20
0.47
1.2
1.3
—
—
—
0
0
363
3790
0.94
0.46
2.7
3.5
1222.87
1831.50
ng/l
4.24
316
3344
36
301
1.20
0.46
4.9
3.1
7.94
7.88
kpa
0.08
36
295
40
338
1.19
0.46
3.9
3.4
0.77
0.82
nmol/l
0.43
33
273
24
192
1.26
0.45
1.5
1.7
—
—
—
0
0
75
839
0.89
0.44
3.4
4.0
1.24
1.22
mmol/l
1.46
60
721
17
130
1.31
0.44
1.4
1.4
—
—
—
0
0
8
57
1.41
0.42
1.4
1.2
—
—
—
0
0
18
140
1.29
0.42
1.8
2.6
25.00
21.21
mg/l
—
5
53
237
2502
0.93
0.42
2.2
2.6
—
—
—
0
0
20
250
0.80
0.41
1.4
2.1
102.35
87.15
%
2.44
20
240
0
15
0.00
0.41
0.0
8.9
—
10.29
—
0
15
0
16
0.00
0.41
0.0
1.3
—
1.39
—
0
7
0
16
0.00
0.41
0.0
1.3
—
0.98
—
0
7
0
16
0.00
0.41
0.0
1.3
—
1.41
—
0
7
0
16
0.00
0.41
0.0
1.4
—
54.94
—
0
16
8
59
1.36
0.41
1.4
1.2
—
—
—
0
0
8
59
1.36
0.41
1.4
1.2
—
—
—
0
0
8
59
1.36
0.41
1.4
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
30
250
1.21
0.40
1.3
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
2.4
—
76.83
—
0
12
0
18
0.00
0.40
0.0
1.4
—
80.67
—
0
12
52
591
0.87
0.40
4.5
4.1
1.02
1.02
ratio
0.90
47
539
0
19
0.00
0.39
0.0
2.3
—
2.10
—
0
11
17
134
1.27
0.37
1.7
1.6
—
—
—
0
0
9
71
1.27
0.36
1.4
1.2
—
—
—
0
0
21
171
1.23
0.36
1.2
1.5
—
—
—
0
0
102
1105
0.92
0.35
4.0
3.6
—
—
—
0
0
19
154
1.24
0.34
1.5
1.3
—
—
—
0
0
131
1400
0.93
0.33
2.2
4.2
218.19
253.40
u/l
3.93
116
1323
28
328
0.85
0.33
1.6
1.9
—
—
—
0
0
11
83
1.33
0.32
1.7
2.5
11.52
7.59
mmol/l
0.56
11
83
29
248
1.17
0.32
1.2
1.2
—
—
—
0
0
20
240
0.83
0.31
1.5
1.2
—
2.63
—
0
24
18
218
0.82
0.30
3.4
4.0
15.67
29.99
mg/l
3.18
12
155
10
75
1.34
0.30
1.1
1.1
—
212.00
—
0
10
874
8834
0.95
0.29
35.8
30.9
130.06
131.97
g/l
3.57
868
8712
874
8831
0.95
0.27
35.6
30.6
4.30
4.37
e12/l
3.99
858
8599
874
8831
0.95
0.27
35.7
30.7
237.65
238.07
e9/l
0.06
862
8632
111
1041
1.07
0.27
2.4
2.6
6.44
6.32
ug/l
0.03
82
909
874
8830
0.95
0.27
35.5
30.6
91.92
91.86
fl
0.15
868
8704
84
780
1.08
0.27
2.7
3.2
130.85
125.84
g/l
1.53
84
759
8
66
1.21
0.26
1.1
1.4
—
—
—
0
0
8
66
1.21
0.26
1.1
1.4
—
—
—
0
0
255
2458
1.05
0.26
3.1
2.8
5.10
4.87
e6/l
0.12
228
2250
287
2775
1.05
0.26
5.5
4.4
0.00
0.01
estimate
0.78
80
963
856
8646
0.95
0.25
12.8
13.5
22.85
25.05
u/l
3.62
818
8351
116
1095
1.07
0.25
4.8
6.6
9.42
11.55
mmol/l
3.35
108
1049
45
407
1.11
0.24
4.4
3.6
1.33
3.87
ratio
1.65
32
243
386
3959
0.96
0.24
5.6
6.4
2.77
4.82
ug/l
1.14
341
3535
66
610
1.09
0.24
1.5
1.8
1.62
1.56
g/l
0.21
54
534
24
208
1.16
0.24
1.5
1.4
—
—
—
0
0
875
8831
0.95
0.24
36.1
31.2
38.96
39.40
%
1.63
869
8700
12
147
0.81
0.23
1.3
1.2
—
—
—
0
0
28
247
1.14
0.22
1.1
1.2
—
—
—
0
0
27
305
0.88
0.22
1.6
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
98.18
—
0
11
0
12
0.00
0.21
0.0
1.8
—
5.12
—
0
12
0
13
0.00
0.21
0.0
11.4
—
5.32
—
0
13
10
80
1.25
0.20
1.0
1.1
128.10
109.89
%
—
10
73
0
14
0.00
0.20
0.0
6.0
—
—
—
0
0
22
250
0.88
0.20
2.2
2.4
178.17
83.48
ug/min
—
10
147
14
164
0.85
0.18
1.6
1.4
19188.89
101787.23
e6/l
—
9
97
7
58
1.21
0.18
1.7
1.2
93.71
93.08
u/l
—
7
50
313
3204
0.97
0.18
5.3
5.2
20.41
21.94
%
1.11
161
1760
95
904
1.06
0.17
1.3
1.4
—
—
—
0
0
18
157
1.15
0.17
2.7
2.5
—
634.40
—
0
15
253
2464
1.03
0.17
4.5
4.1
0.00
0.05
estimate
0.89
64
833
48
446
1.08
0.17
4.4
3.7
33.70
81.35
mg/l
1.10
43
389
5
67
0.75
0.17
1.8
1.8
76.80
103.57
ng/l
—
5
67
17
148
1.15
0.17
1.8
1.6
—
—
—
0
0
17
194
0.87
0.16
1.5
1.2
—
2.28
—
0
13
5
70
0.71
0.16
1.4
1.1
—
—
—
0
0
48
447
1.08
0.16
4.5
3.7
38.43
66.89
mg/l
1.33
43
387
12
141
0.85
0.16
1.3
1.1
331.00
312.83
u/ml
—
6
69
8
71
1.13
0.16
2.3
2.4
—
64.27
—
0
15
11
93
1.18
0.14
1.5
1.2
—
—
—
0
0
436
4426
0.98
0.14
2.5
3.0
—
—
estimate
—
0
0
13
112
1.16
0.14
1.0
1.0
—
—
—
0
0
81
773
1.05
0.14
7.4
9.1
0.65
0.65
%
0.01
81
767
8
99
0.81
0.13
1.0
1.6
—
—
—
0
0
8
99
0.81
0.13
1.0
1.6
—
—
—
0
0
8
99
0.81
0.13
1.0
1.6
—
—
—
0
0
14
159
0.88
0.13
1.2
1.1
—
—
—
0
0
873
8679
1.03
0.13
30.1
25.0
139.73
139.53
mmol/l
1.25
864
8508
22
242
0.91
0.13
3.3
2.6
16.21
15.79
%
0.26
22
237
873
8779
0.97
0.12
31.4
27.5
78.64
85.85
umol/l
10.54
865
8660
14
124
1.13
0.11
1.8
2.2
—
—
—
0
0
117
1206
0.97
0.11
4.6
5.3
36.30
32.94
%
2.09
77
747
873
8688
1.02
0.10
30.3
25.2
3.96
4.02
mmol/l
9.29
864
8505
6
54
1.11
0.09
1.8
1.3
74.33
29.69
u/l
—
6
45
6
57
1.05
0.08
1.2
1.2
—
—
—
0
0
6
57
1.05
0.08
1.2
1.2
—
—
—
0
0
5
62
0.81
0.08
1.0
1.2
0.11
2.44
u/ml
—
5
34
5
65
0.77
0.08
7.6
4.0
—
—
—
0
0
7
66
1.06
0.08
1.0
1.1
94.29
97.34
%
—
7
61
46
441
1.04
0.07
3.0
2.8
—
—
—
0
0
9
84
1.07
0.07
1.0
1.1
—
—
—
0
0
9
86
1.05
0.07
1.1
1.6
—
—
—
0
0
81
793
1.02
0.05
7.4
9.1
91.56
93.95
%
1.39
81
787
30
312
0.96
0.04
1.4
1.6
—
—
—
0
0
10
91
1.10
0.04
1.3
1.2
—
68.14
—
0
7
77
755
1.02
0.04
2.6
3.4
67.68
57.26
ml/min/173m2
1.02
31
348
11
101
1.09
0.04
2.1
1.6
—
—
—
0
0
113
1140
0.99
0.01
2.2
2.9
6.60
9.05
umol/l
1.78
102
1020
24
247
0.97
0.01
1.7
1.6
—
—
—
0
0
11
104
1.06
0.01
1.8
2.2
—
—
—
0
0
20
206
0.97
0.00
1.6
1.8
46.95
44.21
nmol/l
0.20
20
193
27
276
0.98
0.00
3.3
3.5
7.47
7.53
mmol/l
0.04
27
269
12
116
1.03
0.00
2.1
2.7
—
—
—
0
0
14
136
1.03
0.00
1.4
1.3
138.57
170.01
au/ml
—
7
38
21
214
0.98
0.00
1.3
1.2
—
—
—
0
0
80
802
1.00
0.00
7.5
8.8
1.47
1.30
%
0.77
80
795
198
1979
1.00
0.00
1.4
1.6
1.56
1.51
mg/l
0.06
162
1569
663
6632
1.00
0.00
30.3
25.2
13.77
13.96
%
4.14
658
6543
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
-0.00
1.1
1.3
—
—
—
0
0
35
350
1.00
-0.00
2.0
1.8
3.46
7.83
iu/ml
—
9
84
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.4
—
74.80
—
0
5
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
6.80
—
0
5
0
5
0.00
-0.00
0.0
11.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
20.66
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
40.60
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint G6_DEGENOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DEGENOTH | 3.447 [3.0, 3.96] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.576 |
During the follow-up period (1.1.1998 — 31.12.2019), 2005 out of 3191 females with G6_DEGENOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DEGENOTH | 3.577 [3.04, 4.2] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2129 out of 3230 males with G6_DEGENOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_DEGENOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.489% | 0.688% |
| 5 | 2.564% | 3.686% |
| 10 | 5.012% | 9.047% |
| 15 | 9.392% | 16.18% |
| 20 | 16.978% | 26.346% |
Relationships between endpoints
↥Index endpoint: G6_DEGENOTH – Other and unspecified degenerative diseases of nervous system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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