motor neuron disease: A disease involving the motor neuron.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
886 |
4. Check minimum number of eventsNone |
886 |
5. Include endpointsNone |
886 |
6. Filter based on genotype QC (FinnGen only) |
802 |
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G12
- Name in latin
- Morbus motoneuronalis
Similar endpoints
↥List of similar endpoints to
Motor neuron disease ALS
based on the number of shared cases.
Similar with more cases:
- Motor neuron disease (with DMD)
- Systemic atrophies primarily affecting the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8362 | 3928 | 4249 |
| Only index persons | 4490 | 2114 | 2376 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.11 | 0.12 |
| Only index persons | 0.08 | 0.08 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 66.30 | 67.33 | 65.35 |
| Only index persons | 67.14 | 68.36 | 66.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 802 | 339 | 463 |
| Unadjusted period prevalence (%) | 0.17 | 0.12 | 0.21 |
| Median age at first event (years) | 68.34 | 68.58 | 68.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 817
- Matched controls
- 8170
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J96.1
ICD-10 Finland
Chronic respiratory failure
43.4
307.7
223
70
JDB10
NOMESCO Finland
Percutaneous gastrostomy
133.6
307.7
194
19
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
132.6
307.7
243
26
G12.2
ICD-10 Finland
Motor neuron disease
4503599627370496.0
307.7
792
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
22.8
266.8
211
123
N28
ICPC
Limited function/disability (N)
122.8
246.1
125
12
N99
ICPC
Neurological disease other
773.5
241.1
226
*
R13
ICD-10 Finland
Dysphagia
16.8
238.2
223
179
R4130
NOMESCO Finland
Speech therapy
54.7
237.6
137
30
N07XX02
ATC
riluzole; oral
+∞
237.4
216
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
30.1
233.9
161
66
Z51.5
ICD-10 Finland
Palliative care
10.3
220.2
319
479
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
20.4
203.0
165
100
TAB00
NOMESCO Finland
Lumbar puncture
45.5
190.2
114
29
R47.1
ICD-10 Finland
Dysarthria and anarthria
683.7
173.1
165
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
37.8
149.8
94
28
A28
ICPC
Limited function/disability NOS
6.4
129.0
280
617
G47.3
ICD-10 Finland
Sleep apnoea
12.8
128.2
133
122
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
8.9
123.8
174
241
M03BX01
ATC
baclofen; systemic
72.9
123.3
67
10
SPAT1229
SPAT
Assessment of need for aid
11.8
121.8
134
134
XG466
NOMESCO Finland
Sleep oxymetry
26.2
120.4
85
36
L28
ICPC
Limited function/disability (L)
5.7
109.0
260
616
N03AE01
ATC
clonazepam; systemic
20.5
108.7
85
46
R5140
NOMESCO Finland
Monitoring the use of the aid
12.0
107.4
115
110
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
50.6
105.0
61
13
R1250
NOMESCO Finland
Evaluation of functional capability
30.1
103.0
69
25
WX725
NOMESCO Finland
Noninvasive ventilation
8.5
97.8
138
190
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
10.6
94.6
110
118
R4120
NOMESCO Finland
Occupational therapy
9.8
91.2
113
132
R4190
NOMESCO Finland
Nutritional therapy
10.6
83.5
96
101
N29
ICPC
Neurological sympt/complt other
38.8
82.3
51
14
N05AH04
ATC
quetiapine; oral
9.9
79.4
96
108
D21
ICPC
Swallowing problem
35.4
78.7
50
15
N02AA01
ATC
morphine; systemic, rectal
11.0
75.6
84
84
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
10.3
73.7
86
92
S06.0
ICD-10 Finland
Concussion
14.5
73.2
68
51
R5599
NOMESCO Finland
Other rehabilitation service
12.9
70.3
70
59
R1260
NOMESCO Finland
Evaluation of communicative skills
22.1
69.5
52
25
SPAT1231
SPAT
Assessment of adjustments needed in living environment
27.0
66.4
46
18
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.5
64.5
188
508
AA1AD
NOMESCO Finland
CT of head and brain
4.1
63.9
217
657
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
8.0
63.0
90
124
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
12.1
62.9
65
58
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
29.5
62.5
42
15
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
6.4
61.8
111
196
N06AB10
ATC
escitalopram; oral
5.5
61.4
133
280
N06AX11
ATC
mirtazapine; oral
3.8
60.8
242
816
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
28.7
60.5
41
15
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
21.1
60.4
46
23
G12.9
ICD-10 Finland
Spinal muscular atrophy, unspecified
+∞
59.1
56
*
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
10.1
57.9
68
73
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
6.3
56.0
102
182
N05BA04
ATC
oxazepam; oral
3.9
55.4
204
648
SPAT1216
SPAT
Assessment of functional ability
4.2
53.5
168
476
XA402
NOMESCO Finland
ENMG
19.2
52.9
42
23
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
8.6
52.7
70
88
N05BA06
ATC
lorazepam; systemic, sublingual
9.5
51.7
63
71
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
12.0
51.3
53
47
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
98.2
50.5
55
6
TJD20
NOMESCO Finland
Change of gastrostomy tube
96.3
49.5
54
6
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
49.2
183
582
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
20.4
47.8
37
19
N19
ICPC
Speech disorder
173.5
47.4
49
*
SPAT1245
SPAT
Provision of support and information to patient’s family members
9.0
46.5
59
70
F51.0
ICD-10 Finland
Nonorganic insomnia
+∞
45.2
43
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
13.8
44.5
42
32
UDQ12
NOMESCO Finland
Flexible laryngoscopy
6.1
43.9
80
142
N18
ICPC
Paralysis/weakness
74.2
43.5
49
7
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.8
42.7
150
456
R47.8
ICD-10 Finland
Other and unspecified speech disturbances
81.3
41.3
46
6
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
12.7
40.4
40
33
N05AX08
ATC
risperidone; systemic
13.7
40.2
38
29
SPAT1215
SPAT
Assessment of need for medical rehabilitation
8.5
40.1
53
66
R5110, ,
SPAT
4.4
40.0
110
279
SPAT1234
SPAT
Support of social functional capacity
7.4
38.6
58
84
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
58.0
37.7
44
8
N06AB04
ATC
citalopram; systemic
3.9
37.3
125
366
G72.9
ICD-10 Finland
Myopathy, unspecified
373.1
36.3
36
*
N02AA05
ATC
oxycodone; systemic
2.9
35.5
210
869
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.8
35.4
121
359
G12.8
ICD-10 Finland
Other spinal muscular atrophies and related syndromes
+∞
33.6
32
*
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
11.0
33.3
36
34
N03AX12
ATC
[U] gabapentin; oral
3.5
31.3
121
388
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
5.1
30.9
68
143
UDQ42
NOMESCO Finland
Endoscopic assessment of swallowing function
68.6
29.1
33
5
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
11.1
28.8
31
29
XA800
NOMESCO Finland
Neuropsychological investigation
37.6
28.6
36
10
G56.0
ICD-10 Finland
Carpal tunnel syndrome
6.2
28.5
50
85
R25.3
ICD-10 Finland
Fasciculation
66.5
28.1
32
5
F80.1
ICD-10 Finland
Expressive language disorder
291.0
27.9
28
*
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
+∞
27.2
26
*
N06AX21
ATC
duloxetine; oral
4.6
27.0
67
156
A06AD11
ATC
lactulose; oral
3.0
26.6
133
496
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
26.3
262
1371
XG416
NOMESCO Finland
Measurement of maximal airway pressure
+∞
26.2
25
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
10.7
25.5
28
27
G31.0
ICD-10 Finland
Circumscribed brain atrophy
+∞
25.1
24
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
+∞
25.1
24
*
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
40.2
25.0
31
8
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.4
24.6
226
1137
R4120, ,
SPAT
35.7
24.4
31
9
SPAT1254
SPAT
Administration of medicine
2.9
24.2
124
468
SPAT1297
SPAT
Other function in accordance with speech therapy nomenclature
+∞
24.1
23
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.3
23.0
238
1255
SPAT1240
SPAT
Therapeutic discussion
5.4
22.9
46
89
G20
ICD-10 Finland
Parkinson disease
236.4
22.7
23
*
NXL00
NOMESCO Finland
Biopsy of muscle
236.4
22.7
23
*
GX2D5
NOMESCO Finland
Sleep oximetry
123.5
22.7
24
*
ACC51
NOMESCO Finland
Release of median nerve
53.6
22.2
26
5
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
22.1
243
1309
N03AF01
ATC
carbamazepine; oral, rectal
6.7
21.9
35
54
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
25.9
21.9
30
12
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.1
21.8
62
160
S01.0
ICD-10 Finland
Open wound of scalp
3.7
21.8
73
212
T05
ICPC
Feeding problem of adult
32.1
21.6
28
9
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
4.5
21.4
54
127
G30.1
ICD-10 Finland
Alzheimer disease with late onset
51.5
21.2
25
5
N05CF01
ATC
zopiclone; oral
2.2
21.2
226
1200
WPA10
NOMESCO Finland
Proactive palliative care treatment plan
8.2
21.0
28
35
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
61.7
21.0
24
*
G12.1
ICD-10 Finland
Other inherited spinal muscular atrophy
+∞
20.9
20
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
+∞
20.9
20
*
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
+∞
20.9
20
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
+∞
19.9
19
*
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
+∞
19.9
19
*
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
29.8
19.7
26
9
XG467
NOMESCO Finland
Nocturnal CO2 monitoring
107.7
19.6
21
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.9
19.3
58
156
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
19.2
165
797
Z31.5
ICD-10 Finland
Genetic counselling
4.1
19.0
53
135
JDB01
NOMESCO Finland
Laparoscopic gastrostomy
+∞
18.8
18
*
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
17.6
18.8
29
17
Z50.5
ICD-10 Finland
Speech therapy
19.9
18.3
27
14
R53
ICD-10 Finland
Malaise and fatigue
2.3
18.1
152
726
N06AA09
ATC
amitriptyline; systemic
3.7
17.9
59
169
R49.08
ICD-10 Finland
Other specified dysphonia
7.1
17.9
27
39
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.2
17.8
75
252
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
17.9
17.0
26
15
N05BA01
ATC
diazepam; systemic, rectal
2.9
16.9
84
310
XW5WT
NOMESCO Finland
Other blood specimen with radiologicl guidance
64.7
16.8
19
*
R26.2
ICD-10 Finland
Difficulty in walking, not elsewhere classified
6.9
16.7
26
39
R47.0
ICD-10 Finland
Dysphasia and aphasia
173.4
16.6
17
*
N06DA02
ATC
donepezil; oral
41.0
16.4
20
5
N06AX16
ATC
venlafaxine; oral
3.7
16.4
53
150
N06AX26
ATC
vortioxetine; oral
6.5
16.4
27
43
R06.0
ICD-10 Finland
Dyspnoea
2.0
16.3
211
1192
J96.0
ICD-10 Finland
Acute respiratory failure
7.2
16.2
24
34
XX9TE
NOMESCO Finland
Compementary ultrasound examination
25.1
16.1
22
9
M48.0
ICD-10 Finland
Spinal stenosis
2.6
15.8
97
400
3352A
ICD-9 Finland
Anterior horn cell disease, Motor neuron disease[SCLEROSIS LATERALIS AMYOTROPHICA]
+∞
15.7
15
*
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
15.7
15
*
N04BC05
ATC
pramipexole; oral
3.8
15.6
49
136
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
16.4
15.3
24
15
WX722
NOMESCO Finland
PEEP
4.9
15.3
34
72
XG410
NOMESCO Finland
Flow-volume spirometry
4.0
14.9
43
112
SPAT1139
SPAT
Nutrition survey
5.2
14.9
31
62
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
4.1
14.8
41
104
N03AG01
ATC
valproic acid; systemic, rectal
18.8
14.7
22
12
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
21.5
14.7
21
10
WX781
NOMESCO Finland
Remote monitoring, noninvasive ventilation
+∞
14.6
14
*
30041
ICD-8 Finland
Neuroses, Depressiva
+∞
14.6
14
*
K90
ICPC
Stroke/cerebrovascular accident
36.8
14.5
18
5
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
27.7
14.3
19
7
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
13.0
14.0
24
19
A29
ICPC
General symptom/complaint other
2.3
13.9
116
549
Z50.1
ICD-10 Finland
Other physical therapy
3.4
13.9
50
152
G56.2
ICD-10 Finland
Lesion of ulnar nerve
24.3
13.8
19
8
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
24.3
13.8
19
8
L19
ICPC
Muscle symptom/complaint NOS
5.2
13.7
28
55
G62.8
ICD-10 Finland
Other specified polyneuropathies
76.4
13.6
15
*
N06AB06
ATC
sertraline; oral
3.7
13.6
43
120
G40.9
ICD-10 Finland
Epilepsy, unspecified
142.3
13.5
14
*
N87
ICPC
Parkinsonism
142.3
13.5
14
*
N05AH03
ATC
olanzapine; systemic
14.1
13.3
22
16
M54.1
ICD-10 Finland
Radiculopathy
4.4
13.2
33
77
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
4.3
13.1
34
82
SPAT1167
SPAT
Insertion of urinary catheter
4.1
13.0
36
91
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
0.4
13.0
63
1476
SPAT1262
SPAT
Handing over of treatment supplies
2.1
12.9
131
672
A04
ICPC
Weakness/tiredness general
2.4
12.7
96
435
ZY010
NOMESCO Finland
Hospital outpatient
4.6
12.7
30
67
M62.5
ICD-10 Finland
Muscle wasting and atrophy, not elsewhere classified
71.0
12.6
14
*
WPA42
NOMESCO Finland
Family-centered psychosocial intervention in palliative care
71.0
12.6
14
*
WW200, ,
SPAT
0.4
12.6
86
1749
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
10.3
12.5
24
24
R41.0
ICD-10 Finland
Disorientation, unspecified
9.5
12.5
25
27
RS314, ,
NOMESCO Finland
+∞
12.5
12
*
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
+∞
12.5
12
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
+∞
12.5
12
*
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
132.0
12.5
13
*
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.7
12.4
67
258
Z3229
NOMESCO Finland
Other healthcare associate professional
2.6
12.4
72
288
SPAT1301
SPAT
No procedures
1.8
12.4
217
1342
N06DX01
ATC
memantine; oral
38.2
12.2
15
*
WPA13
NOMESCO Finland
Palliative consultation
12.6
12.2
21
17
N05AN01
ATC
lithium; oral
47.4
11.9
14
*
J96.9
ICD-10 Finland
Respiratory failure, unspecified
14.9
11.8
19
13
GX1P5
NOMESCO Finland
Nocturnal CO2 monitoring
65.9
11.6
13
*
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
8.8
11.6
24
28
N03AX16
ATC
[U] pregabalin
2.0
11.6
131
698
RS310, ,
NOMESCO Finland
+∞
11.5
11
*
WX723
NOMESCO Finland
CPAP therapy
+∞
11.5
11
*
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
+∞
11.5
11
*
K11.72
ICD-10 Finland
Xerostomia
+∞
11.5
11
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.0
11.4
32
82
P03
ICPC
Feeling depressed
4.3
11.4
29
69
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
15.3
11.3
18
12
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
11.3
121
2110
U04
ICPC
Incontinence urine
3.1
11.2
47
157
WPA43
NOMESCO Finland
A doctor's home visit to perform palliative care
25.4
11.2
15
6
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
25.4
11.2
15
6
Z2445
NOMESCO Finland
Psychologist
20.4
11.2
16
8
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.1
11.0
30
75
RS340, ,
NOMESCO Finland
43.9
10.9
13
*
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
12.1
10.9
19
16
R4110
NOMESCO Finland
Physiotherapy
1.8
10.8
212
1350
N07AA02
ATC
pyridostigmine; systemic
60.8
10.6
12
*
UJC01
NOMESCO Finland
Scopy of lower throat
9.3
10.6
21
23
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
111.4
10.4
11
*
RS122, ,
NOMESCO Finland
111.4
10.4
11
*
Z99.8
ICD-10 Finland
Dependence on other enabling machines and devices
111.4
10.4
11
*
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
111.4
10.4
11
*
P29
ICPC
Psychological sympt/compl other
5.5
10.4
20
37
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
+∞
10.4
10
*
TJD10
NOMESCO Finland
Insertion of other tube into stomach or duodenum
+∞
10.4
10
*
85000
ICD-8 Finland
Concussion, Current or unspecified
+∞
10.4
10
*
G81.9
ICD-10 Finland
Hemiplegia, unspecified
+∞
10.4
10
*
A120_, ,
NOMESCO Finland
+∞
10.4
10
*
A210_, ,
NOMESCO Finland
+∞
10.4
10
*
G35
ICD-10 Finland
Multiple sclerosis
+∞
10.4
10
*
Z3226
NOMESCO Finland
Physiotherapist
2.0
10.3
128
703
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
8.9
10.3
21
24
WPA10, ,
SPAT
23.7
10.3
14
6
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.0
10.1
28
71
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
9.3
10.1
20
22
WYA20
NOMESCO Finland
Home visit
10.2
10.0
19
19
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
9.9
132
744
G72.8
ICD-10 Finland
Other specified myopathies
55.7
9.7
11
*
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
55.7
9.7
11
*
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
55.7
9.7
11
*
N06DA03
ATC
rivastigmine; oral, transdermal
55.7
9.7
11
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
55.7
9.7
11
*
L99
ICPC
Musculoskeletal disease other
4.5
9.6
23
52
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.2
9.6
85
412
P20
ICPC
Memory disturbance
2.4
9.5
70
313
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
101.2
9.4
10
*
Z93.1
ICD-10 Finland
Gastrostomy status
101.2
9.4
10
*
Z43.1
ICD-10 Finland
Attention to gastrostomy
101.2
9.4
10
*
RS313, ,
NOMESCO Finland
101.2
9.4
10
*
R4130, ,
SPAT
101.2
9.4
10
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
30.4
9.4
12
*
SPAT1252
SPAT
Overall medication plan or its review
2.7
9.4
52
203
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
+∞
9.4
9
*
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
9.4
9
*
ACC53
NOMESCO Finland
Release of ulnar nerve
+∞
9.4
9
*
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.8
9.4
48
180
GX1D5
NOMESCO Finland
Flow volume spirometry
22.0
9.4
13
6
SPAT1276
SPAT
Outlining of treatment with patient or their family members
5.0
9.3
20
41
N05CD07
ATC
temazepam; oral
2.3
9.2
71
324
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.0
9.2
99
517
R06.5
ICD-10 Finland
Mouth breathing
2.9
9.1
43
154
SPAT1125
SPAT
Stoma care and guidance
5.1
9.1
19
38
EB1VA, ,
NOMESCO Finland
0.3
9.1
22
737
WPA44, ,
SPAT
15.8
9.1
14
9
WPA44
NOMESCO Finland
Nursing home for palliative care
18.8
9.0
13
7
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
18.8
9.0
13
7
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
24.3
8.9
12
5
SPAT1172
SPAT
Guidance concerning hydration
5.0
8.9
19
39
W19
ICD-10 Finland
Unspecified fall
2.4
8.8
60
259
N06AB03
ATC
fluoxetine; oral
2.6
8.8
52
210
RS311, ,
NOMESCO Finland
50.5
8.7
10
*
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
50.5
8.7
10
*
F34.1
ICD-10 Finland
Dysthymia
50.5
8.7
10
*
A98
ICPC
Health maint/preventive medicine
0.6
8.7
616
6840
130
Kela drug reimbursment
Malignant tumour
0.3
8.6
18
657
F03
ICD-10 Finland
Unspecified dementia
8.3
8.6
18
22
RK110, ,
NOMESCO Finland
11.7
8.6
15
13
S28
ICPC
Limited function/disability (S)
11.7
8.6
15
13
EB4VA, ,
NOMESCO Finland
0.3
8.6
19
671
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
16.5
8.6
13
8
N81
ICPC
Injury nervous system other
91.0
8.4
9
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
91.0
8.4
9
*
G44.2
ICD-10 Finland
Tension-type headache
2.7
8.4
46
179
G61.8
ICD-10 Finland
Other inflammatory polyneuropathies
+∞
8.3
8
*
A220_, ,
NOMESCO Finland
+∞
8.3
8
*
IGY99
NOMESCO Finland
Other psychiatric treatment contact
+∞
8.3
8
*
3472A
ICD-9 Finland
Cataplexy and narcolepsy[OBSTRUKTIIVINEN UNIAPNEA]
+∞
8.3
8
*
R27.0
ICD-10 Finland
Ataxia, unspecified
+∞
8.3
8
*
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
9.6
8.3
16
17
RS221, ,
NOMESCO Finland
9.6
8.3
16
17
A06AH03
ATC
naloxegol; oral
4.4
8.2
20
46
M03BX02
ATC
tizanidine; oral
1.5
8.1
396
3110
WPA43, ,
SPAT
11.8
8.1
14
12
XA421
NOMESCO Finland
Nocturnal polygraphy
33.7
8.1
10
*
WPA40
NOMESCO Finland
Individual-centered psychosocial intervention in palliative care
33.7
8.1
10
*
OAB50
NOMESCO Finland
Delivery of care equipment and instruction on their use
33.7
8.1
10
*
TNX05
NOMESCO Finland
Simple incision of soft tissue, unspecified region
33.7
8.1
10
*
Z75.5
ICD-10 Finland
Holiday relief care
33.7
8.1
10
*
NJ3BG
NOMESCO Finland
MRI examination of extremities with high intensity magnet
17.4
8.1
12
7
N03AX09
ATC
lamotrigine; oral
17.4
8.1
12
7
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
9.0
8.1
16
18
RS222, ,
NOMESCO Finland
10.2
8.1
15
15
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
4.2
8.0
21
51
G04BD12
ATC
mirabegron; oral
2.0
8.0
85
441
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
4.5
7.9
19
43
WPA11
NOMESCO Finland
Developing a plan for palliative care
13.2
7.9
13
10
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.5
7.9
26
75
H02AB02
ATC
dexamethasone; systemic
0.3
7.8
23
696
N05AX12
ATC
aripiprazole; systemic
45.4
7.7
9
*
R1420
NOMESCO Finland
Assessment of rehabilitation needs and/or compilation of rehabilitation plan
45.4
7.7
9
*
JDB00
NOMESCO Finland
Gastrostomy
45.4
7.7
9
*
G30.8
ICD-10 Finland
Other Alzheimer disease
45.4
7.7
9
*
WPA15
NOMESCO Finland
Palliative care consultation with the patient and loved ones
8.1
7.6
16
20
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
10.2
7.5
14
14
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
0.6
7.5
134
2060
XKD06
NOMESCO Finland
Physiologic investigation of micturition
3.6
7.5
24
68
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
0.1
7.4
*
268
N04AA02
ATC
biperiden; systemic
80.8
7.4
8
*
RS211, ,
NOMESCO Finland
80.8
7.4
8
*
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
80.8
7.4
8
*
RS230, ,
NOMESCO Finland
13.5
7.4
12
9
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
+∞
7.3
7
*
34800
ICD-8 Finland
Motor neurone disease, Amyotrophic lateral sclerosis
+∞
7.3
7
*
G99.2*M47.1
ICD-10 Finland
Spondylogenic compression of spinal cord
+∞
7.3
7
*
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
+∞
7.3
7
*
G12.0
ICD-10 Finland
Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]
+∞
7.3
7
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
+∞
7.3
7
*
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
+∞
7.3
7
*
WX780
NOMESCO Finland
Remote monitoring CPAP
+∞
7.3
7
*
R42
ICD-10 Finland
Dizziness and giddiness
1.7
7.3
135
837
OAA67, ,
SPAT
0.2
7.3
14
537
R63.4
ICD-10 Finland
Abnormal weight loss
2.8
7.2
36
134
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.9
7.2
91
503
M47.9
ICD-10 Finland
Spondylosis, unspecified
4.1
7.1
19
47
L01BC06
ATC
capecitabine; oral
0.1
7.0
*
252
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.9
7.0
31
108
Z2446
NOMESCO Finland
Social worker
2.6
7.0
38
148
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
5.9
6.9
18
31
S01.1
ICD-10 Finland
Open wound of eyelid and periocular area
3.6
6.9
22
62
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
13.9
6.9
11
8
N05AA02
ATC
levomepromazine; systemic
8.4
6.8
14
17
F06.7
ICD-10 Finland
Mild cognitive disorder
8.4
6.8
14
17
N02BF01
ATC
gabapentin; oral
2.3
6.8
52
237
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
6.8
59
284
M60.9
ICD-10 Finland
Myositis, unspecified
16.9
6.8
10
6
C10AA07
ATC
rosuvastatin; oral
0.6
6.8
119
1842
N06AX03
ATC
mianserin; oral
3.9
6.7
19
49
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
22.7
6.7
9
*
WPA41
NOMESCO Finland
Psychosocial conversational support in palliative care
22.7
6.7
9
*
A04AA02
ATC
granisetron; systemic, transdermal
0.2
6.7
8
346
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
6.6
75
400
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
10.1
6.5
12
12
Z73.6
ICD-10 Finland
Limitation of activities due to disability
10.1
6.5
12
12
R03BA08
ATC
ciclesonide; inhalant
2.2
6.5
51
236
N06AA12
ATC
doxepin; systemic
3.0
6.4
27
91
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
70.4
6.4
7
*
N04BD01
ATC
selegiline; oral
70.4
6.4
7
*
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
70.4
6.4
7
*
Z43.0
ICD-10 Finland
Attention to tracheostomy
70.4
6.4
7
*
R33
ICD-10 Finland
Retention of urine
2.0
6.4
68
353
G51.0
ICD-10 Finland
Bell palsy
14.4
6.4
10
7
M09AA72
ATC
quinine, combinations with psycholeptics; systemic
3.1
6.4
26
86
Z3231
NOMESCO Finland
Registered nurse
1.6
6.4
173
1182
T36
ICD-10 Finland
Poisoning by systemic antibiotics
11.1
6.3
11
10
P01
ICPC
Feeling anxious/nervous/tense
2.9
6.3
28
98
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
+∞
6.3
6
*
G83.2
ICD-10 Finland
Monoplegia of upper limb
+∞
6.3
6
*
N86
ICPC
Multiple sclerosis
+∞
6.3
6
*
RP120, ,
NOMESCO Finland
+∞
6.3
6
*
N05BA09
ATC
clobazam; oral
+∞
6.3
6
*
A222_, ,
NOMESCO Finland
+∞
6.3
6
*
A123_, ,
NOMESCO Finland
+∞
6.3
6
*
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
+∞
6.3
6
*
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
+∞
6.3
6
*
N04BC04
ATC
ropinirole; oral
+∞
6.3
6
*
A211_, ,
NOMESCO Finland
+∞
6.3
6
*
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
+∞
6.3
6
*
AA5DR
NOMESCO Finland
Brain metabolism PET with CT
+∞
6.3
6
*
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
+∞
6.3
6
*
RS142, ,
NOMESCO Finland
+∞
6.3
6
*
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
+∞
6.3
6
*
G61.9
ICD-10 Finland
Inflammatory polyneuropathy, unspecified
+∞
6.3
6
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
+∞
6.3
6
*
D28
ICPC
Limited function/disability (D)
26.9
6.2
8
*
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
26.9
6.2
8
*
ZYC01
NOMESCO Finland
Remote contact by phone
2.5
6.2
37
151
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
7.8
6.1
13
17
Z29
ICPC
Social problem NOS
6.8
6.1
14
21
V700A
ICD-9 Finland
General medical examination, Routine general medical examination at a health care facility
3.5
6.0
20
58
N05CD08
ATC
midazolam; nasal, systemic
3.9
6.0
17
44
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
3.9
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
104
24
49.51
177.28
1.2
1.2
547.46
19.12
e6/l
0.58
81
17
103
23
51.10
176.87
1.1
1.1
7.74
38.20
e6/l
0.55
74
15
87
12
81.02
162.72
1.0
1.1
—
—
—
0
0
468
1420
6.37
155.74
2.5
1.8
240.06
190.37
u/l
1.34
452
1334
207
286
9.35
148.92
2.6
2.4
18.59
22.70
au/ml
0.25
15
38
192
266
9.13
137.26
1.4
1.3
69.71
49.89
au/ml
—
7
36
167
243
8.38
113.59
4.6
4.2
3.70
1.83
mmol/l
6.06
153
183
90
8
126.21
84.84
1.0
1.0
—
—
—
0
0
84
8
116.86
78.55
1.1
1.0
—
—
—
0
0
189
537
4.28
60.40
1.6
3.0
67.86
65.97
g/l
3.39
176
501
114
232
5.55
54.46
1.4
2.2
2.47
3.04
g/l
7.58
108
214
117
253
5.23
52.14
1.4
2.2
4.19
4.05
g/l
1.23
111
235
117
253
5.23
52.14
1.4
2.2
3.40
3.88
g/l
1.91
110
235
117
253
5.23
52.14
1.4
2.2
6.68
7.38
g/l
5.03
111
235
207
737
3.42
46.55
5.7
7.1
5.95
5.06
kpa
9.51
202
703
206
737
3.40
45.91
5.7
7.0
10.60
12.37
kpa
8.69
200
705
102
219
5.18
45.65
1.3
2.1
10.08
10.76
g/l
0.61
95
199
203
735
3.34
44.23
5.7
7.0
4.19
0.59
mmol/l
24.05
179
595
76
171
4.80
31.95
1.4
1.8
0.00
0.00
g/l
-0.00
70
160
72
162
4.78
30.25
1.6
2.3
171.13
453.32
ug/l
1.25
65
152
78
188
4.48
30.10
1.5
1.8
0.00
0.06
g/l
0.80
72
166
86
225
4.15
29.82
1.5
2.0
0.63
1.60
g/l
0.99
78
187
76
184
4.45
29.15
1.4
1.8
0.00
0.00
g/l
-0.00
70
160
120
408
3.28
28.18
1.8
3.5
10.70
11.13
g/l
0.57
105
381
433
2731
2.25
28.04
3.6
5.2
36.18
35.00
g/l
4.73
411
2563
118
2679
0.35
26.28
1.8
1.8
1.27
1.27
mmol/l
0.01
104
2195
205
983
2.45
24.85
1.7
1.8
—
—
—
0
0
79
230
3.70
23.49
1.7
2.0
38.56
38.75
u/l
0.03
73
194
181
859
2.42
22.20
1.7
1.6
1142.30
1148.39
nmol/l
0.03
143
650
28
37
7.80
20.05
1.0
2.1
—
—
—
0
0
156
731
2.40
19.49
1.7
1.7
—
—
—
0
0
438
3043
1.95
19.11
5.8
7.2
1.22
1.21
mmol/l
4.97
376
2614
192
994
2.22
18.93
2.4
3.5
0.83
0.82
mmol/l
0.21
173
937
146
690
2.36
17.79
1.7
1.7
—
—
—
0
0
541
6481
0.51
17.09
4.3
5.7
2.77
2.71
mmol/l
0.81
474
5920
528
6371
0.52
17.00
4.0
4.9
4.71
4.63
mmol/l
0.93
461
5840
49
128
4.01
16.94
3.0
2.2
142.12
127.22
g/l
4.21
41
95
526
6329
0.53
16.13
4.0
4.8
1.50
1.47
mmol/l
0.65
459
5767
20
6
34.11
15.79
1.1
1.0
23.88
27.83
ng/l
—
14
6
19
6
32.37
14.85
1.1
1.0
284.21
243.33
ng/l
—
14
6
385
2717
1.79
14.59
6.1
6.3
1.22
1.21
mmol/l
1.83
355
2513
200
1162
1.95
14.02
1.5
1.7
453.15
34136548.80
pmol/l
1.25
172
955
18
6
30.62
13.92
1.1
1.0
872.80
968.50
ng/l
—
10
6
461
3499
1.73
12.96
5.0
4.4
6.45
6.78
mmol/l
4.15
447
3315
400
2924
1.72
12.86
14.4
16.5
1.30
1.31
inr
0.21
337
2399
509
6044
0.58
11.97
5.1
6.1
38.15
39.34
mmol/mol
3.12
458
5561
510
6045
0.58
11.76
3.6
4.1
1.22
1.24
mmol/l
0.21
442
5458
246
1642
1.71
10.54
1.6
1.6
21.35
19.93
nmol/l
0.81
220
1328
361
2698
1.61
9.76
2.1
1.9
93.87
94.69
pmol/l
0.11
196
1380
77
371
2.19
8.79
1.6
1.6
—
—
—
0
0
83
414
2.12
8.68
6.7
8.6
27.23
24.15
mmol/l
11.09
78
406
154
2321
0.59
8.15
3.4
4.1
9.61
7.85
mg/mmol
0.21
90
1422
157
2311
0.60
7.41
2.6
3.3
7.72
7.48
mmol/l
0.28
126
1908
14
15
9.47
7.30
1.0
1.1
—
—
—
0
0
36
133
2.79
7.27
1.3
1.3
—
—
—
0
0
548
6190
0.65
7.24
4.3
5.0
5.86
5.93
mmol/l
1.02
497
5575
547
6181
0.65
7.24
15.8
15.1
90.79
75.55
ml/min/173m2
38.87
498
5671
638
6956
0.62
6.84
25.0
22.0
135.05
135.47
g/l
0.33
633
6837
128
797
1.72
6.80
3.4
5.7
0.99
1.05
mmol/l
1.83
117
741
638
6954
0.62
6.79
24.8
21.8
4.43
4.48
e12/l
1.59
619
6717
638
6954
0.62
6.79
25.6
22.3
40.21
40.31
%
0.16
632
6824
638
6953
0.62
6.76
24.7
21.8
91.91
91.57
fl
1.09
631
6830
638
6952
0.62
6.74
24.8
21.9
244.25
241.97
e9/l
0.43
622
6741
106
628
1.79
6.69
3.2
3.6
4.57
1.54
mmol/l
8.74
98
518
618
6771
0.64
6.49
10.8
11.5
28.51
25.38
u/l
5.26
601
6506
95
551
1.82
6.43
7.0
7.3
1.02
1.26
mmol/l
3.31
90
543
75
403
1.95
6.41
1.7
2.3
436.33
402.67
nmol/l
0.85
66
380
10
7
14.44
6.41
1.1
1.0
—
—
—
0
0
10
7
14.44
6.41
1.1
1.0
—
—
—
0
0
525
4492
1.47
6.37
4.1
3.9
11.33
13.51
mm/h
3.00
497
4146
9
8
11.36
5.30
1.1
1.0
—
—
—
0
0
127
1837
0.63
5.23
2.6
3.4
0.81
0.87
ug/l
0.29
96
1257
102
644
1.67
5.13
3.9
2.8
—
—
—
0
0
277
2169
1.42
5.09
4.2
3.2
55.48
74.53
ng/l
0.37
247
1620
11
16
6.95
4.96
1.0
1.0
—
—
—
0
0
633
6826
0.68
4.88
21.2
19.7
64.87
81.83
umol/l
42.67
627
6709
8
7
11.52
4.79
1.3
1.0
—
—
—
0
0
466
5268
0.73
4.54
22.9
19.1
332.27
332.04
g/l
0.21
460
5225
8
8
10.08
4.52
1.1
1.0
—
—
—
0
0
416
3546
1.35
4.36
6.2
10.2
4.05
4.10
e9/l
0.18
358
3010
31
139
2.28
4.30
1.2
1.2
—
1.88
—
0
5
35
170
2.11
4.01
1.3
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
7
10.07
4.01
1.0
1.0
—
—
—
0
0
72
445
1.68
3.95
1.4
1.4
—
—
—
0
0
452
3940
1.33
3.90
5.0
3.9
2246.18
3613.90
e6/l
0.20
11
51
261
2100
1.36
3.88
2.5
4.2
2.37
2.36
mmol/l
0.83
238
1892
8
11
7.33
3.86
1.0
1.0
—
—
—
0
0
26
114
2.32
3.81
1.5
1.3
0.39
0.27
mg/l
0.60
13
49
42
223
1.93
3.80
1.6
1.9
—
—
—
0
0
6
5
12.07
3.77
1.0
1.0
—
—
—
0
0
66
406
1.68
3.69
1.5
1.5
1.41
1.38
%
0.15
58
350
38
197
1.97
3.68
1.6
1.8
—
—
—
0
0
39
205
1.95
3.64
1.6
1.6
10.47
6.82
iu/ml
—
10
38
7
9
7.83
3.56
1.1
1.0
—
—
—
0
0
7
9
7.83
3.56
1.0
1.0
—
—
—
0
0
10
21
4.81
3.56
1.0
1.1
—
—
—
0
0
10
23
4.39
3.31
1.0
2.6
41.26
39.17
g/l
—
10
23
9
19
4.78
3.24
1.1
1.1
—
—
—
0
0
64
411
1.60
3.06
1.6
1.6
—
—
—
0
0
232
1903
1.31
2.90
2.8
3.2
38.48
37.17
u/l
0.08
224
1783
57
863
0.64
2.81
2.9
5.3
10.89
38.03
ug/l
1.22
46
727
137
1048
1.37
2.74
1.4
1.2
1.03
1.27
u/ml
0.31
30
264
58
378
1.58
2.64
2.7
4.0
27.19
23.83
mmol/l
8.08
58
373
12
42
2.88
2.55
2.1
1.8
6.38
7.56
mmol/l
1.01
12
42
202
2423
0.78
2.45
3.9
4.8
21.64
21.73
%
0.03
112
1341
5
161
0.31
2.43
1.0
1.1
1.36
1.56
g/l
—
5
161
482
4384
1.24
2.40
3.5
3.7
15.18
14.94
pmol/l
1.29
454
3932
151
1198
1.32
2.38
1.8
1.6
1.21
1.52
mg/l
0.85
122
936
20
98
2.07
2.33
1.3
1.2
—
—
—
0
0
20
98
2.07
2.33
1.3
1.2
—
—
—
0
0
256
2969
0.80
2.30
4.1
6.2
5.51
3.70
ug/l
0.35
222
2691
371
3304
1.23
2.18
5.0
7.7
11.32
12.41
umol/l
1.77
358
3159
625
6576
0.79
2.13
20.5
17.1
139.82
139.77
mmol/l
0.20
616
6406
626
6585
0.79
2.13
20.5
17.3
3.93
4.00
mmol/l
8.50
613
6399
66
468
1.45
2.07
2.9
3.9
1.22
1.23
mmol/l
0.83
52
409
407
3676
1.21
2.03
3.4
2.7
39.78
52.56
u/l
4.76
385
3382
44
654
0.65
2.03
1.4
1.4
—
—
—
0
0
7
21
3.35
1.97
6.0
2.4
5.72
4.98
kpa
—
7
21
7
21
3.35
1.97
6.0
2.4
9.07
10.85
kpa
—
7
21
6
16
3.77
1.93
1.7
2.1
—
—
—
0
0
28
167
1.70
1.86
1.4
1.5
—
—
—
0
0
63
454
1.42
1.84
2.4
3.6
72.10
95.02
ng/l
1.83
55
406
8
182
0.43
1.83
1.4
3.4
13.14
859.96
u/ml
—
8
170
13
60
2.19
1.78
1.2
2.0
—
—
—
0
0
144
1182
1.26
1.76
3.5
3.5
717.61
664.65
ng/l
0.03
126
987
10
40
2.52
1.67
2.1
4.3
—
—
—
0
0
10
41
2.46
1.64
1.7
1.1
—
—
—
0
0
117
945
1.28
1.63
1.3
1.2
31.14
42.19
iu/ml
0.27
28
290
65
482
1.38
1.63
2.7
2.3
11.29
7.32
ug/l
0.36
58
442
10
42
2.40
1.62
1.7
1.1
—
—
—
0
0
12
56
2.16
1.61
1.2
2.0
—
—
—
0
0
20
113
1.79
1.61
1.4
1.7
—
—
—
0
0
142
1690
0.81
1.54
2.5
2.9
340.28
358.18
umol/l
1.32
123
1487
11
52
2.13
1.45
1.4
1.3
—
—
—
0
0
6
22
2.74
1.43
1.0
1.3
—
—
—
0
0
19
111
1.73
1.40
1.2
1.3
—
—
—
0
0
7
29
2.43
1.39
1.3
1.8
—
—
—
0
0
40
282
1.44
1.36
1.4
1.3
—
—
—
0
0
33
224
1.49
1.35
1.8
2.4
—
—
—
0
0
6
24
2.51
1.30
1.2
1.8
—
—
—
0
0
6
24
2.51
1.30
1.2
1.8
—
—
—
0
0
26
169
1.56
1.30
1.5
1.6
—
—
—
0
0
5
18
2.79
1.28
1.0
1.2
—
—
—
0
0
10
48
2.10
1.28
1.0
1.1
2.00
3.26
u/ml
—
5
23
23
146
1.59
1.27
1.6
1.4
—
—
—
0
0
8
35
2.30
1.27
1.1
1.8
—
—
—
0
0
8
35
2.30
1.27
1.1
1.8
—
—
—
0
0
8
35
2.30
1.27
1.1
1.8
—
—
—
0
0
8
35
2.30
1.27
1.1
1.8
—
—
—
0
0
6
25
2.41
1.24
1.2
1.8
—
—
—
0
0
12
63
1.92
1.23
1.1
1.6
—
—
—
0
0
12
63
1.92
1.23
1.1
1.6
—
—
—
0
0
12
63
1.92
1.23
1.1
1.6
—
—
—
0
0
5
19
2.64
1.21
1.2
2.4
61.32
54.85
ug/l
—
5
19
145
1242
1.20
1.21
2.6
3.4
2.46
2.47
mmol/l
0.15
129
1119
42
309
1.38
1.16
1.3
1.2
258.31
223.45
u/ml
0.12
37
287
8
153
0.52
1.15
1.5
1.3
—
—
—
0
0
5
21
2.39
1.09
1.2
2.8
—
—
—
0
0
25
169
1.49
1.08
2.8
3.4
2.31
2.19
index
0.03
13
89
7
32
2.20
1.08
1.0
3.4
1388.71
1363.69
u/ml
—
7
32
8
148
0.54
1.04
1.3
1.2
—
—
—
0
0
7
34
2.07
1.03
2.3
1.4
—
—
—
0
0
10
177
0.56
1.02
5.7
2.8
1.49
1.63
mg/l
—
10
151
7
35
2.01
1.00
1.0
1.2
—
—
—
0
0
7
133
0.52
0.99
2.0
5.2
—
238.21
—
0
19
0
30
0.00
0.97
0.0
1.3
—
10.87
—
0
30
7
36
1.95
0.97
2.3
1.4
—
—
—
0
0
9
50
1.81
0.97
1.0
1.2
—
—
—
0
0
252
2301
1.14
0.94
3.4
3.2
—
—
—
0
0
18
118
1.54
0.91
1.7
1.4
—
—
—
0
0
21
143
1.48
0.90
3.8
2.7
70.20
63.20
%
0.85
21
143
5
103
0.48
0.89
2.6
2.7
—
2244.50
—
0
8
8
43
1.87
0.87
2.1
1.3
—
—
—
0
0
101
867
1.19
0.86
3.0
4.7
237.65
251.82
u/l
0.53
96
831
227
2074
1.13
0.84
3.3
3.3
43.94
90.55
e6/l
0.93
168
1571
198
1795
1.14
0.83
3.2
3.2
0.70
0.56
e6/l
0.31
145
1301
8
47
1.71
0.81
1.6
1.3
—
—
—
0
0
325
3040
1.11
0.80
2.6
2.2
—
—
—
0
0
16
106
1.52
0.79
1.8
1.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
7
123
0.57
0.78
1.1
1.6
—
—
—
0
0
9
55
1.64
0.73
1.1
1.1
103.44
104.15
pmol/l
—
9
55
509
4892
1.11
0.72
6.4
8.5
72.23
81.16
u/l
7.85
481
4626
12
76
1.59
0.72
1.6
1.5
—
—
—
0
0
22
160
1.39
0.71
1.5
1.3
—
—
—
0
0
9
58
1.56
0.70
3.4
2.4
—
—
—
0
0
18
127
1.43
0.68
1.8
1.4
—
—
—
0
0
87
757
1.17
0.66
7.5
6.2
—
—
—
0
0
15
103
1.46
0.65
1.1
1.3
—
—
—
0
0
10
62
1.62
0.65
1.0
1.0
—
16.29
—
0
16
12
79
1.53
0.63
1.3
1.4
—
—
—
0
0
279
2619
1.10
0.62
2.1
2.2
79.09
80.23
nmol/l
0.25
243
2337
6
101
0.59
0.62
1.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
9.64
—
0
8
0
20
0.00
0.60
0.0
1.5
—
1.30
—
0
8
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
10
64
1.57
0.58
1.2
1.2
—
—
—
0
0
12
82
1.47
0.54
1.6
1.5
—
—
—
0
0
569
5536
1.09
0.54
4.4
4.4
1.94
2.08
mu/l
1.48
535
4941
218
2038
1.10
0.53
2.9
3.1
1004.27
1549.73
ng/l
1.81
182
1807
77
871
0.87
0.52
1.3
1.2
7.63
18.13
u/ml
1.32
29
329
6
97
0.62
0.52
1.5
1.5
—
—
—
0
0
45
526
0.85
0.47
2.6
3.0
107.06
59.77
ml/min/173m2
0.76
17
229
7
48
1.46
0.47
1.0
1.4
0.20
0.20
nmol/l
—
7
36
7
49
1.43
0.46
1.0
1.5
—
92.86
—
0
7
7
50
1.40
0.45
1.0
1.0
—
—
—
0
0
117
1074
1.10
0.43
1.9
2.6
13.88
12.54
umol/l
0.91
103
1021
5
32
1.57
0.42
1.8
1.2
—
—
—
0
0
5
32
1.57
0.42
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
30
250
1.21
0.41
1.7
4.5
33.63
54.17
mg/l
0.93
23
224
5
34
1.47
0.40
1.0
1.2
—
—
—
0
0
5
34
1.47
0.40
1.0
1.2
—
—
—
0
0
5
34
1.47
0.40
1.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
11.7
—
5.99
—
0
18
5
36
1.39
0.38
1.0
1.2
—
—
—
0
0
5
36
1.39
0.38
1.0
1.2
—
—
—
0
0
5
36
1.39
0.38
1.0
1.2
—
—
—
0
0
26
216
1.21
0.37
1.1
1.0
—
—
—
0
0
6
42
1.43
0.35
1.0
1.3
—
—
—
0
0
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
6
44
1.37
0.34
1.3
1.1
—
—
—
0
0
188
1786
1.07
0.32
4.0
3.4
0.00
0.01
estimate
0.78
63
603
50
557
0.89
0.31
2.6
2.4
36.24
36.34
u/l
0.01
42
470
148
1566
0.93
0.31
2.1
2.6
—
—
—
0
0
16
129
1.25
0.30
1.3
1.3
—
—
—
0
0
29
251
1.16
0.28
1.8
4.5
35.10
283.95
mg/l
0.64
22
222
122
1151
1.07
0.26
2.8
3.0
1.22
1.03
e6/l
0.25
73
635
18
150
1.20
0.26
2.2
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
25
216
1.16
0.25
2.8
2.6
0.35
0.31
iu/ml
0.29
15
114
6
85
0.70
0.24
1.0
1.2
1.68
1.56
g/l
—
6
79
16
135
1.19
0.21
1.3
1.1
—
—
—
0
0
16
135
1.19
0.21
1.3
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
7.2
—
10.38
—
0
13
14
166
0.84
0.20
1.8
1.6
55.50
43.59
nmol/l
0.74
14
159
106
1008
1.06
0.20
1.7
2.6
2.22
2.25
g/l
0.21
90
948
112
1070
1.05
0.18
2.7
3.2
1.60
1.58
e6/l
0.01
62
554
144
1386
1.05
0.18
3.1
2.6
7.43
5.59
e6/l
0.52
131
1255
160
1546
1.04
0.17
2.2
2.2
2.79
2.82
mg/l
0.05
131
1327
15
173
0.86
0.17
3.0
2.3
3.62
3.67
g/l
0.04
15
165
9
78
1.16
0.15
3.3
4.4
—
—
—
0
0
9
80
1.13
0.15
2.7
1.3
—
—
—
0
0
141
1365
1.04
0.14
3.9
3.4
1.02
1.02
kg/l
0.61
98
878
298
2924
1.03
0.14
2.2
2.8
—
—
estimate
—
0
0
13
149
0.87
0.13
1.1
1.3
—
—
—
0
0
313
3184
0.97
0.13
3.8
3.4
0.00
0.00
estimate
-0.00
71
671
74
772
0.95
0.12
3.9
4.7
34.36
33.04
%
0.43
44
450
31
289
1.08
0.11
1.1
1.2
95.17
151.91
u/ml
—
9
104
618
6139
1.03
0.11
17.5
14.2
25.98
28.79
mg/l
1.07
549
4858
322
3265
0.98
0.10
3.8
3.4
0.00
0.00
estimate
-0.00
71
645
98
950
1.04
0.10
1.8
2.5
24.82
22.46
%
0.89
88
901
5
45
1.11
0.10
1.4
1.3
—
23.14
—
0
7
65
676
0.96
0.09
1.3
1.3
—
—
—
0
0
5
46
1.09
0.09
1.0
1.3
—
—
—
0
0
318
3220
0.98
0.09
3.9
3.4
0.00
3.95
estimate
0.80
72
679
24
223
1.08
0.09
1.8
1.4
—
—
—
0
0
172
1687
1.02
0.09
3.4
3.0
0.00
0.00
estimate
0.50
61
492
16
174
0.92
0.07
1.5
1.4
—
—
—
0
0
19
176
1.08
0.07
4.1
2.8
1.78
1.61
mmol/l
0.32
19
171
250
2532
0.98
0.07
2.6
2.9
158.73
161.65
ug/l
0.04
227
2353
7
81
0.86
0.07
1.0
1.0
—
—
—
0
0
30
315
0.95
0.06
2.0
1.7
1.46
1.49
g/l
0.06
25
276
15
162
0.92
0.06
2.1
1.8
91.07
87.21
%
0.26
15
155
23
218
1.06
0.05
1.8
4.2
1.40
6.98
ratio
0.89
11
135
65
665
0.98
0.04
2.3
2.8
7.38
9.95
umol/l
0.83
57
594
22
209
1.05
0.04
1.3
1.2
—
—
—
0
0
16
150
1.07
0.04
1.9
1.4
—
—
—
0
0
13
137
0.95
0.01
1.2
1.6
—
—
—
0
0
241
2417
1.00
0.00
3.9
3.3
0.02
0.03
estimate
0.29
66
538
15
145
1.04
0.00
2.4
2.4
13.80
85.59
ug/min
—
5
85
10
97
1.03
0.00
2.5
1.4
—
—
—
0
0
20
196
1.02
0.00
2.0
1.3
—
—
—
0
0
16
159
1.01
0.00
1.8
1.7
—
—
—
0
0
184
1837
1.00
0.00
2.3
2.3
51.84
62.35
u/l
3.00
170
1682
0
9
0.00
-0.00
0.0
4.2
—
6.18
—
0
9
7
71
0.99
-0.00
1.4
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
7
74
0.95
-0.00
1.4
1.4
—
—
—
0
0
7
71
0.99
-0.00
1.4
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
0.25
—
0
8
0
7
0.00
-0.00
0.0
1.1
—
9.34
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
74
0.95
-0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
31.33
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
71
0.99
-0.00
1.4
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
22.96
—
0
7
6
67
0.89
-0.00
1.2
1.3
5.50
12.90
u/l
—
6
61
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
23.00
—
0
7
0
5
0.00
-0.00
0.0
4.8
—
53.80
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
37.06
—
0
7
7
74
0.95
-0.00
1.4
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_ALS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALS | 18.515 [14.27, 24.02] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.318 |
During the follow-up period (1.1.1998 — 31.12.2019), 2037 out of 2507 females with G6_ALS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALS | 9.357 [7.48, 11.7] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.04 |
During the follow-up period (1.1.1998 — 31.12.2019), 1983 out of 2612 males with G6_ALS died.
Mortality risk
Mortality risk for people of age
years, who have G6_ALS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.608% | 1.809% |
| 5 | 9.35% | 11.766% |
| 10 | 22.668% | 26.493% |
| 15 | 41.38% | 44.597% |
| 20 | 62.462% | 65.032% |
Relationships between endpoints
↥Index endpoint: G6_ALS – Motor neuron disease ALS
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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