cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
296 |
4. Check minimum number of eventsNone |
296 |
5. Include endpointsNone |
296 |
6. Filter based on genotype QC (FinnGen only) |
270 |
Control definitions (FinnGen only)
- Control exclude
- CIRRHOSIS_BROAD
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K74
- Name in latin
- Fibrosis hepatis
Similar endpoints
↥List of similar endpoints to
Fibrosis of liver
based on the number of shared cases.
Similar with more cases:
- Fibrosis and cirrhosis of liver
- Cirrhosis, broad definition used in the article https://doi.org/10.1101/594523
- Diseases of liver
- Gastrointestinal diseases
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1501 | 735 | 747 |
| Only index persons | 1232 | 625 | 607 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 59.22 | 59.75 | 58.57 |
| Only index persons | 58.22 | 58.24 | 58.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 270 | 132 | 138 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | 60.20 | 56.82 | 63.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 278
- Matched controls
- 2780
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K74.0
ICD-10 Finland
Hepatic fibrosis
+∞
307.7
278
*
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
84.7
130.1
70
11
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
50.8
120.4
72
19
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
+∞
95.4
86
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
27.8
94.1
68
32
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
11.3
77.7
102
136
A05AA02
ATC
ursodeoxycholic acid; oral
29.7
62.6
43
17
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.7
55.4
174
557
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
15.9
44.3
40
29
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
+∞
39.5
37
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.5
35.9
89
219
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.3
30.9
120
416
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
+∞
30.8
29
*
L04AX01
ATC
azathioprine; systemic
9.2
30.7
40
50
C03DA01
ATC
spironolactone; oral
5.1
30.3
78
196
103
Kela drug reimbursment
Diabetes, insulin-treated
4.0
28.8
130
498
A10AE04
ATC
insulin glargine; parenteral
5.0
24.8
63
155
R18
ICD-10 Finland
Ascites
23.3
24.6
35
17
A10BA02
ATC
metformin; oral
3.6
24.1
127
527
T90
ICPC
Diabetes non-insulin dependent
3.6
23.7
118
471
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.6
23.4
118
474
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
130.8
23.0
24
*
C03CA01
ATC
furosemide; systemic
3.5
22.4
121
505
K76.9
ICD-10 Finland
Liver disease, unspecified
26.8
21.3
29
12
N17.9
ICD-10 Finland
Acute renal failure, unspecified
8.0
20.3
29
40
A10BH01
ATC
sitagliptin; oral
4.5
19.7
56
149
D64.9
ICD-10 Finland
Anaemia, unspecified
4.4
19.2
56
152
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
22.9
19.0
27
13
A41.9
ICD-10 Finland
Sepsis, unspecified
8.0
19.0
27
37
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.1
18.2
42
94
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.9
18.1
44
103
K74.3
ICD-10 Finland
Primary biliary cirrhosis
71.5
18.0
20
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
4.0
17.9
60
180
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
+∞
17.9
17
*
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
191.7
17.7
18
*
E66.00
ICD-10 Finland
Metabolic syndrome
5.6
17.2
35
70
127
Kela drug reimbursment
Transplant complication
24.9
16.7
23
10
JJC00
NOMESCO Finland
Allogenic transplantation of liver
180.4
16.7
17
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.6
16.7
65
216
SPAT1262
SPAT
Handing over of treatment supplies
3.3
16.0
74
274
Z94.4
ICD-10 Finland
Liver transplant status
63.9
16.0
18
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.8
15.8
56
174
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
11.8
15.4
28
26
C07AG02
ATC
carvedilol; oral
4.9
14.7
35
80
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.6
14.7
38
93
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
14.7
14
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.7
14.6
36
85
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
21.4
14.0
20
10
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
146.9
13.6
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
13.4
172
1066
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
13.1
13.4
23
19
UJF30
NOMESCO Finland
Ileoscopy through colon
3.4
12.7
51
171
K70.0
ICD-10 Finland
Alcoholic fatty liver
+∞
12.6
12
*
A10AB05
ATC
insulin aspart; parenteral
3.8
12.5
42
125
XW000
NOMESCO Finland
Bone marrow biopsy
5.5
12.5
25
49
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
12.4
72
300
D97
ICPC
Liver disease NOS
48.9
12.0
14
*
K83.0
ICD-10 Finland
Cholangitis
13.4
11.8
20
16
L04AD01
ATC
ciclosporin; systemic
13.4
11.8
20
16
A10BJ06
ATC
semaglutide; parenteral
4.2
11.8
33
86
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
8.9
11.6
24
29
K70.4
ICD-10 Finland
Alcoholic hepatic failure
+∞
11.5
11
*
K72.1
ICD-10 Finland
Chronic hepatic failure
+∞
11.5
11
*
A07EA06
ATC
budesonide; oral, local oral
5.0
11.2
25
54
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.5
11.2
96
484
R04.0
ICD-10 Finland
Epistaxis
3.7
11.0
38
115
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
+∞
10.5
10
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
33.9
10.4
13
*
A06AD11
ATC
lactulose; oral
3.0
10.4
51
192
L04AD02
ATC
tacrolimus; systemic
24.5
10.3
14
6
WX872
NOMESCO Finland
Intensive care
4.1
10.2
29
76
J01MA02
ATC
ciprofloxacin; systemic
2.3
10.2
129
764
K92.1
ICD-10 Finland
Melaena
4.4
10.2
27
67
K29.3
ICD-10 Finland
Chronic superficial gastritis
5.2
10.0
21
43
L04AA06
ATC
mycophenolic acid; systemic
10.6
9.7
18
18
UJF32
NOMESCO Finland
Coloscopy
2.3
9.6
94
497
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
4.0
9.6
28
75
A07AA11
ATC
rifaximin; oral
+∞
9.4
9
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.8
9.3
54
223
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.7
9.3
22
50
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.5
9.2
33
102
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
9.2
112
647
TPH07
NOMESCO Finland
Cathetrisation of artery
2.9
9.1
49
194
K72.9
ICD-10 Finland
Hepatic failure, unspecified
38.0
9.1
11
*
WW500
NOMESCO Finland
Blood transfusion
4.6
9.0
22
51
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
7.2
9.0
21
31
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
19.4
9.0
13
7
A10BX07
ATC
[U] liraglutide
11.2
8.9
16
15
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
51.7
8.7
10
*
K75.4
ICD-10 Finland
Autoimmune hepatitis
51.7
8.7
10
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.3
8.7
23
57
160
Kela drug reimbursment
exenatide
7.1
8.5
20
30
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
8.3
8.5
18
23
H02AB06
ATC
prednisolone; systemic
2.1
8.4
150
996
R50.9
ICD-10 Finland
Fever, unspecified
2.5
8.4
59
267
A02BC02
ATC
pantoprazole; systemic
2.3
8.4
209
1578
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
+∞
8.4
8
*
K74.2
ICD-10 Finland
Hepatic fibrosis with hepatic sclerosis
+∞
8.4
8
*
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
+∞
8.4
8
*
JJ5AT, ,
NOMESCO Finland
+∞
8.4
8
*
A10BB12
ATC
glimepiride; oral
3.5
8.3
30
93
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
8.3
42
160
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
8.3
80
417
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
8.2
64
304
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
34.4
8.1
10
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
8.1
115
698
RS220, ,
NOMESCO Finland
22.8
8.1
11
5
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.8
8.1
45
181
WX402
NOMESCO Finland
General anaesthesia
2.2
8.0
83
446
WX892
NOMESCO Finland
Monitored bed care
3.2
8.0
33
112
J01MA12
ATC
levofloxacin; systemic
2.4
8.0
63
301
ZXE40
NOMESCO Finland
More than seven and less than nine hours
7.3
7.9
18
26
WX882
NOMESCO Finland
High dependency care
6.7
7.9
19
30
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
12.3
7.7
13
11
R11
ICD-10 Finland
Nausea and vomiting
2.9
7.5
37
139
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
13.9
7.5
12
9
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.6
7.4
46
195
205
Kela drug reimbursment
Chronic hypertension
2.2
7.4
84
465
C07AA05
ATC
propranolol; systemic
2.3
7.4
70
360
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.4
7.4
59
282
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.0
7.4
21
55
162
Kela drug reimbursment
liraglutide
9.8
7.4
14
15
K92.0
ICD-10 Finland
Haematemesis
9.8
7.4
14
15
A10BK03
ATC
empagliflozin; oral
2.6
7.3
47
203
ZX120
NOMESCO Finland
Intravenous
2.8
7.3
38
147
TK800
NOMESCO Finland
Hemodialysis
7.6
7.3
16
22
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
6.3
7.2
18
30
K55.8
ICD-10 Finland
Other vascular disorders of intestine
30.9
7.2
9
*
B18.2
ICD-10 Finland
Chronic viral hepatitis C
12.5
7.1
12
10
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.1
7.1
14
16
A10BH05
ATC
linagliptin; oral
3.5
7.0
25
77
A10BK01
ATC
dapagliflozin; oral
3.0
7.0
32
115
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.2
7.0
19
48
H02AB04
ATC
methylprednisolone; systemic
2.5
7.0
50
227
C01DA14
ATC
isosorbide mononitrate; oral
2.5
6.9
47
208
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.5
6.9
49
222
E66.8
ICD-10 Finland
Other obesity
3.7
6.9
22
63
K29.6
ICD-10 Finland
Other gastritis
11.3
6.9
12
11
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
17.2
6.8
10
6
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
41.1
6.8
8
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
41.1
6.8
8
*
J01FF01
ATC
clindamycin; systemic
2.1
6.7
88
512
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
6.7
96
577
R4190
NOMESCO Finland
Nutritional therapy
3.8
6.6
20
55
A10BG03
ATC
pioglitazone; oral
6.0
6.6
17
30
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
6.5
116
752
N02AX02
ATC
tramadol; systemic, rectal
1.9
6.5
137
939
XF622
NOMESCO Finland
Measurement of minute volume of heart
71.4
6.5
7
*
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
71.4
6.5
7
*
L04AA01
ATC
[U] ciclosporin
14.8
6.4
10
7
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
8.5
6.4
13
16
UJD02
NOMESCO Finland
Gastroscopy
3.5
6.3
22
67
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.5
6.3
22
67
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
+∞
6.3
6
*
K76.7
ICD-10 Finland
Hepatorenal syndrome
+∞
6.3
6
*
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
+∞
6.3
6
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.1
6.3
17
43
S97
ICPC
Chronic ulcer skin
2.9
6.2
29
106
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.2
6.1
25
84
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.2
6.1
25
84
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
12.9
6.1
10
8
N30.0
ICD-10 Finland
Acute cystitis
2.3
6.1
48
227
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
10.4
6.1
11
11
A10BX04
ATC
[U] exenatide
10.4
6.1
11
11
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
6.3
6.1
15
25
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.9
6.1
29
107
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.7
6.1
35
143
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
162
252
14.01
114.07
6.2
2.5
0.19
0.22
g/l
6.56
157
239
124
178
11.77
90.46
1.6
1.7
1.27
1.30
g/l
0.06
116
162
63
29
27.80
87.70
1.4
1.2
—
—
—
0
0
146
417
6.27
52.17
3.5
2.4
2.42
2.30
g/l
1.33
137
388
139
385
6.22
51.24
3.4
2.5
24.04
23.14
%
0.26
134
363
113
296
5.75
43.31
2.2
1.7
1.65
1.51
%
0.86
94
254
74
129
7.45
43.25
2.1
1.6
0.37
0.38
mg/l
0.04
29
55
221
1201
5.10
29.91
23.8
11.9
1.27
1.21
inr
1.33
199
993
140
572
3.92
28.04
1.8
1.4
3.27
2.35
g/l
4.99
117
333
172
819
3.89
27.14
4.7
2.5
60.41
69.72
u/l
0.54
166
759
32
37
9.64
25.92
1.7
1.5
—
—
—
0
0
36
53
7.65
23.96
1.6
1.2
320.06
225.11
u/ml
0.64
18
27
139
630
3.41
22.58
3.8
2.2
3.52
2.80
mg/l
2.63
129
549
203
1284
3.15
16.62
15.9
7.7
1.20
1.21
mmol/l
1.96
177
1119
158
889
2.80
15.84
5.9
4.0
13.11
9.30
mg/mmol
0.34
107
545
187
1156
2.89
15.49
13.5
6.9
1.19
1.21
mmol/l
2.97
181
1077
30
59
5.58
14.95
2.1
1.3
—
—
—
0
0
159
920
2.70
14.74
6.3
3.3
6.72
7.89
mmol/l
2.98
140
764
33
73
4.99
14.42
1.7
1.3
—
—
—
0
0
23
16
15.55
14.33
8.6
3.0
78.91
92.94
%
0.67
23
16
70
267
3.17
14.23
9.3
4.3
1.34
1.80
mmol/l
0.44
60
232
27
52
5.64
13.73
1.8
1.3
119.88
149.16
au/ml
—
8
15
70
276
3.05
13.38
3.9
4.5
3.46
23.43
ug/l
0.70
61
225
212
1460
2.90
13.26
17.3
10.5
3.62
4.07
e9/l
2.78
196
1272
41
116
3.97
13.11
2.4
2.3
1.33
1.54
g/l
0.77
41
104
18
8
23.93
13.07
4.2
2.4
0.59
0.61
mmol/l
—
18
8
41
117
3.94
12.96
4.5
3.0
93.75
1812.40
u/ml
0.78
36
99
20
15
14.26
12.14
1.1
1.1
—
—
—
0
0
71
301
2.82
11.78
9.4
9.5
0.64
1.05
mmol/l
0.32
54
260
84
393
2.63
11.46
2.3
1.6
1213.35
1179.15
nmol/l
0.12
70
306
115
624
2.44
11.45
1.4
1.3
1.09
1.64
u/ml
0.62
35
171
16
9
18.75
10.86
3.6
1.4
3.88
3.99
ug/l
—
16
9
85
421
2.47
10.14
2.7
1.9
—
—
—
0
0
49
184
3.02
10.03
2.2
1.6
—
—
—
0
0
78
378
2.48
9.71
8.7
8.1
103.86
104.03
mmol/l
0.10
78
378
167
1122
2.22
9.48
2.8
2.1
90.11
94.76
pmol/l
0.74
117
579
44
163
3.02
9.19
6.5
3.2
1.48
1.85
mmol/l
0.16
30
121
92
491
2.31
9.15
1.9
1.8
441.97
459.38
pmol/l
0.23
80
413
30
88
3.70
9.06
1.5
1.9
2.92
2.89
g/l
0.06
30
83
26
70
3.99
8.84
2.0
1.5
—
—
—
0
0
31
95
3.55
8.78
1.5
1.8
7.29
7.28
g/l
0.01
31
90
31
95
3.55
8.78
1.5
1.8
4.01
3.39
g/l
2.19
31
90
31
95
3.55
8.78
1.5
1.8
4.58
4.27
g/l
0.82
31
90
108
625
2.19
8.76
4.4
2.4
—
—
—
0
0
15
13
12.12
8.68
1.3
1.2
135.00
78.01
u/l
1.21
15
13
171
1185
2.15
8.65
5.4
2.7
—
—
estimate
—
0
0
24
62
4.14
8.62
2.4
1.9
—
—
—
0
0
58
266
2.49
8.00
3.8
2.5
41.94
34.65
u/l
0.38
52
225
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
25
71
3.77
7.90
3.3
2.4
0.29
0.38
iu/ml
0.64
15
39
126
805
2.03
7.63
4.4
3.1
1014.67
1001.02
ng/l
0.02
104
688
162
1132
2.03
7.63
4.7
2.4
73.14
75.49
nmol/l
0.58
157
1021
112
689
2.05
7.50
5.1
3.0
368.59
345.66
umol/l
1.26
100
601
95
559
2.06
7.12
2.9
1.8
1.58
1.42
mg/l
0.22
78
455
27
88
3.29
6.95
1.4
1.2
—
—
—
0
0
42
177
2.62
6.86
4.4
3.8
115.86
129.15
g/l
2.60
42
171
44
191
2.55
6.77
15.9
10.4
23.55
25.01
mmol/l
1.90
44
191
26
86
3.23
6.54
8.7
2.6
8.77
8.31
kpa
0.43
26
86
14
19
7.70
6.49
1.1
1.0
—
—
—
0
0
23
71
3.44
6.44
1.4
2.6
1.63
2.90
ratio
0.63
16
38
25
82
3.25
6.37
2.4
1.8
—
—
—
0
0
115
754
1.90
6.13
2.2
1.7
20.66
20.77
nmol/l
0.02
102
635
9
6
15.43
5.94
1.0
1.0
—
—
—
0
0
120
806
1.86
5.88
2.9
2.2
310.95
195.99
u/l
0.57
112
764
35
149
2.54
5.59
3.8
3.5
1.15
1.23
%
0.22
35
149
45
216
2.29
5.54
2.5
2.8
55.28
67.36
ml/min/173m2
1.15
25
96
58
309
2.11
5.53
2.7
1.9
—
—
—
0
0
123
846
1.81
5.48
5.7
3.2
859.14
116.51
e6/l
0.42
104
639
227
1895
2.08
5.34
8.3
4.4
19.86
11.21
mm/h
8.28
221
1763
60
329
2.05
5.28
2.6
1.8
—
—
—
0
0
34
147
2.50
5.26
3.8
3.5
0.65
0.61
%
0.24
34
147
16
45
3.71
5.12
1.9
1.7
—
—
—
0
0
109
736
1.79
5.08
5.7
3.1
0.69
0.37
e6/l
0.68
87
526
23
83
2.93
5.01
1.5
1.7
12.89
10.56
g/l
1.09
23
77
21
72
3.07
4.99
2.0
1.7
—
—
—
0
0
29
121
2.56
4.82
1.3
1.8
3.76
5.33
iu/ml
—
7
34
21
74
2.99
4.77
1.9
1.7
—
—
—
0
0
20
71
2.96
4.49
2.5
2.5
145.53
94.24
ug/min
0.24
13
39
16
50
3.33
4.41
8.3
2.8
4.68
4.94
kpa
0.76
16
50
21
78
2.83
4.36
2.4
1.7
—
—
—
0
0
10
17
6.06
4.17
1.2
1.5
—
—
—
0
0
41
214
2.07
4.09
2.6
2.3
7.84
8.61
ug/l
0.09
36
193
9
14
6.60
4.01
3.1
2.4
—
—
—
0
0
20
76
2.76
3.99
2.6
1.1
0.86
0.92
g/l
0.38
20
76
46
253
1.98
3.98
5.1
3.4
—
—
—
0
0
11
23
4.93
3.91
1.1
1.2
—
—
—
0
0
15
49
3.18
3.87
2.0
1.4
—
—
—
0
0
32
155
2.20
3.85
2.1
1.7
—
—
—
0
0
79
527
1.70
3.66
4.7
4.0
270.89
355.12
ng/l
0.21
57
417
129
976
1.60
3.62
5.3
3.7
24.92
34.39
ng/l
1.33
107
706
20
81
2.58
3.55
1.7
2.1
0.39
1.13
g/l
0.55
20
74
9
17
5.43
3.54
1.2
1.5
—
—
—
0
0
12
34
3.64
3.24
2.3
1.5
—
—
—
0
0
11
29
3.90
3.22
1.2
1.9
—
—
—
0
0
19
79
2.51
3.21
1.0
1.3
—
—
—
0
0
10
26
3.95
3.01
1.2
2.0
—
—
—
0
0
21
95
2.31
2.98
3.4
3.0
—
—
—
0
0
163
1340
1.52
2.94
6.2
3.7
32.74
12.64
estimate
0.25
43
277
8
17
4.81
2.94
2.1
1.6
—
—
—
0
0
8
17
4.81
2.94
1.4
1.2
14.19
8.42
ug/l
—
8
17
9
22
4.19
2.90
2.7
1.5
—
—
—
0
0
17
72
2.45
2.78
1.2
1.8
0.00
0.00
g/l
-0.00
17
64
11
34
3.33
2.76
2.5
1.4
—
—
—
0
0
14
55
2.63
2.66
1.9
1.4
—
—
—
0
0
9
25
3.68
2.60
1.4
1.3
—
—
—
0
0
13
50
2.68
2.57
1.0
1.4
—
—
—
0
0
5
7
7.25
2.56
1.2
1.6
49.40
34.43
u/l
—
5
7
8
21
3.89
2.48
3.4
2.9
—
—
—
0
0
62
428
1.58
2.44
4.0
2.9
7.24
2.08
e6/l
0.66
38
204
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
6
12
5.08
2.41
1.5
1.9
149.67
153.42
%
—
6
12
7
17
4.20
2.37
1.4
1.9
10.71
12.94
umol/l
—
7
17
18
86
2.17
2.28
1.6
1.4
—
—
—
0
0
157
1324
1.43
2.23
6.2
3.7
0.00
0.00
estimate
-0.00
42
274
8
24
3.40
2.19
1.4
2.2
240.13
189.00
e6/l
—
8
19
96
742
1.45
2.19
6.5
3.7
0.00
0.02
estimate
0.78
38
254
13
55
2.43
2.15
1.2
1.7
—
—
—
0
0
15
68
2.27
2.15
1.7
1.6
—
—
—
0
0
65
469
1.50
2.09
3.9
2.8
0.73
0.86
e6/l
0.25
40
244
15
69
2.24
2.08
1.2
1.5
274.20
280.84
miu/ml
—
5
30
5
10
5.07
2.08
1.2
1.1
—
—
—
0
0
6
15
4.06
2.05
1.3
1.4
—
—
—
0
0
6
15
4.06
2.05
1.8
2.9
—
—
—
0
0
6
15
4.06
2.05
1.3
1.4
—
—
—
0
0
16
77
2.14
2.01
1.0
1.2
—
1.00
—
0
6
11
45
2.50
1.95
1.2
1.7
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
5
11
4.61
1.95
1.4
1.0
86.40
102.00
%
—
5
11
158
1354
1.39
1.93
6.3
3.8
0.11
1.16
estimate
0.43
35
258
6
17
3.58
1.84
1.8
1.8
0.00
3.88
u/field
—
6
8
5
12
4.22
1.83
3.0
2.1
47.40
139.15
ng/l
—
5
12
24
140
1.78
1.78
2.6
3.6
4.19
4.49
pmol/l
0.82
18
129
122
1013
1.36
1.77
6.4
3.7
0.00
0.01
estimate
0.50
39
233
8
30
2.71
1.73
1.4
1.7
0.46
0.89
mmol/l
—
8
30
5
13
3.90
1.72
1.0
1.1
451.74
200.43
iu/ml
—
5
13
7
25
2.84
1.66
1.4
2.1
504.57
536.06
e6/l
—
7
18
7
25
2.84
1.66
1.0
1.2
—
—
—
0
0
32
208
1.61
1.63
1.9
1.4
—
—
—
0
0
6
20
3.04
1.59
1.2
1.2
84.33
110.30
pmol/l
—
6
20
12
57
2.16
1.57
1.8
1.5
—
—
—
0
0
45
321
1.48
1.53
5.0
5.0
32.45
31.77
%
0.18
38
212
9
37
2.48
1.49
1.2
1.5
—
—
—
0
0
9
37
2.48
1.49
1.2
1.5
—
—
—
0
0
9
37
2.48
1.49
1.2
1.5
—
—
—
0
0
9
37
2.48
1.49
1.1
1.5
—
—
—
0
0
169
1499
1.32
1.48
2.8
2.9
—
—
—
0
0
9
38
2.41
1.47
1.6
1.3
—
—
—
0
0
9
38
2.41
1.47
1.6
1.3
—
—
—
0
0
90
731
1.34
1.46
5.4
3.2
0.00
0.12
estimate
0.52
35
215
256
2435
1.65
1.45
39.4
15.8
19.12
23.94
mg/l
2.52
244
1989
245
2308
1.52
1.45
6.3
4.5
1.47
1.29
mmol/l
3.05
231
2137
60
457
1.40
1.44
1.5
1.3
16.98
9.47
u/ml
0.32
24
178
5
16
3.16
1.44
1.8
1.8
110.80
75.62
umol/l
—
5
16
7
29
2.45
1.40
2.4
1.5
—
—
—
0
0
8
36
2.26
1.25
10.1
4.2
—
—
—
0
0
8
36
2.26
1.25
1.3
1.5
—
—
—
0
0
9
45
2.03
1.24
1.9
2.0
10.59
10.44
mmol/l
—
9
45
205
1891
1.32
1.23
5.2
4.2
15.09
14.79
pmol/l
0.91
192
1725
8
37
2.20
1.22
1.3
1.5
—
—
—
0
0
253
2416
1.52
1.20
7.2
5.5
4.26
4.62
mmol/l
5.87
240
2263
14
79
1.81
1.19
1.6
1.4
264.13
281.30
ug/g
—
8
47
106
903
1.28
1.18
4.1
3.5
2.32
2.36
mmol/l
1.24
100
819
239
2260
1.41
1.18
6.5
5.3
1.89
1.94
mu/l
0.23
230
2084
260
2500
1.62
1.16
46.1
18.8
138.78
139.77
mmol/l
7.21
260
2462
260
2505
1.59
1.09
46.9
19.0
3.97
3.98
mmol/l
0.12
260
2463
10
52
1.96
1.07
5.8
2.9
10.40
8.43
pmol/l
—
10
52
9
46
1.99
1.04
1.3
1.1
—
—
—
0
0
5
22
2.30
1.04
1.4
1.2
508.80
262.15
u/l
—
5
22
5
22
2.30
1.04
1.2
1.4
—
—
—
0
0
7
34
2.09
1.03
1.1
1.3
—
—
—
0
0
246
2352
1.40
1.00
34.4
15.6
79.51
81.02
ml/min/173m2
0.49
235
2189
245
2341
1.39
0.99
12.0
6.6
42.69
39.44
mmol/mol
3.88
236
2203
5
23
2.19
0.98
1.2
1.9
—
—
—
0
0
5
23
2.19
0.98
1.2
1.9
—
—
—
0
0
5
23
2.19
0.98
1.2
1.9
—
—
—
0
0
7
37
1.91
0.94
1.0
1.1
—
—
—
0
0
11
63
1.78
0.91
1.3
1.2
—
—
—
0
0
250
2406
1.39
0.87
7.0
5.3
1.31
1.45
mmol/l
6.38
237
2243
6
31
1.96
0.85
1.8
3.0
109.17
106.16
mmol/l
—
6
31
6
31
1.96
0.85
1.8
3.0
1.19
1.19
mmol/l
—
6
31
50
609
0.78
0.82
2.5
3.1
0.83
0.74
ug/l
0.30
31
394
5
25
2.02
0.73
1.2
1.3
—
—
—
0
0
5
29
1.74
0.64
2.6
1.4
0.46
0.21
nmol/l
—
5
17
0
20
0.00
0.60
0.0
1.1
—
22.95
—
0
6
252
2451
1.30
0.59
7.9
6.2
2.41
2.71
mmol/l
5.81
241
2290
0
23
0.00
0.58
0.0
1.0
—
587.29
—
0
14
0
23
0.00
0.58
0.0
1.1
—
42.70
—
0
12
6
36
1.68
0.57
1.0
1.2
—
—
—
0
0
19
142
1.36
0.56
2.1
1.4
—
—
—
0
0
21
160
1.34
0.55
1.1
1.3
16.93
133.72
u/ml
—
7
65
9
60
1.52
0.55
1.3
1.3
—
—
—
0
0
9
60
1.52
0.55
2.1
1.5
—
—
—
0
0
59
512
1.19
0.54
1.6
1.3
33.27
30.21
iu/ml
0.12
28
162
6
39
1.55
0.53
1.2
1.7
—
—
—
0
0
21
262
0.79
0.45
2.4
2.5
13.28
14.13
nmol/l
0.18
21
235
0
16
0.00
0.41
0.0
7.6
—
35.80
—
0
5
0
17
0.00
0.41
0.0
1.5
—
—
—
0
0
5
37
1.36
0.37
1.0
1.3
—
—
—
0
0
73
797
0.89
0.36
3.9
4.5
25.74
21.62
%
0.87
30
389
261
2570
1.25
0.35
49.5
21.0
81.29
77.89
umol/l
0.92
261
2547
48
428
1.15
0.33
1.6
1.6
—
—
—
0
0
11
84
1.32
0.30
1.5
1.6
—
—
—
0
0
5
74
0.67
0.26
1.0
1.6
289.80
294.69
mu/l
—
5
68
104
986
1.09
0.25
4.8
5.4
1.82
1.96
ug/l
0.18
94
882
7
93
0.75
0.23
1.4
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
117
1127
1.07
0.18
2.0
2.0
1.36
1.36
mmol/l
0.02
98
950
200
2038
0.93
0.17
48.9
20.0
14.57
13.61
%
12.00
200
2024
5
66
0.75
0.17
1.2
1.4
—
—
—
0
0
20
225
0.88
0.17
1.7
2.1
—
—
—
0
0
11
130
0.84
0.16
1.3
1.3
—
—
—
0
0
63
597
1.07
0.15
7.3
3.8
1.02
1.02
kg/l
1.10
43
402
18
202
0.88
0.15
1.6
2.0
—
—
—
0
0
9
110
0.81
0.13
2.0
2.4
—
—
—
0
0
31
288
1.09
0.12
14.6
6.7
—
—
—
0
0
261
2627
0.89
0.11
60.5
24.3
91.66
91.20
fl
0.69
261
2607
261
2627
0.89
0.11
61.3
24.5
128.68
136.52
g/l
9.91
261
2606
261
2627
0.89
0.11
62.0
25.0
38.57
40.78
%
7.41
261
2607
261
2626
0.90
0.10
60.9
24.4
203.88
248.43
e9/l
15.52
261
2582
240
2381
1.06
0.08
7.5
5.3
6.76
5.98
mmol/l
6.84
228
2205
7
67
1.05
0.08
1.0
1.2
—
58.89
—
0
9
6
70
0.85
0.07
1.2
1.3
—
—
—
0
0
8
74
1.08
0.07
1.3
1.2
—
—
—
0
0
8
76
1.05
0.07
1.3
1.2
—
—
—
0
0
31
316
0.98
0.00
1.2
1.5
—
—
—
0
0
14
145
0.96
0.00
1.1
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
73
0.96
-0.00
2.4
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
99.29
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
7.82
—
0
5
6
69
0.87
-0.00
1.2
1.1
—
6.36
—
0
9
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
66.36
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint FIBROLIV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FIBROLIV | 3.993 [3.15, 5.06] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.94 |
During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 599 females with FIBROLIV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FIBROLIV | 5.7 [4.11, 7.91] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 263 out of 545 males with FIBROLIV died.
Mortality risk
Mortality risk for people of age
years, who have FIBROLIV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.386% | 1.014% |
| 5 | 2.546% | 5.439% |
| 10 | 6.983% | 14.34% |
| 15 | 12.573% | 25.688% |
| 20 | 21.768% | 40.077% |
Relationships between endpoints
↥Index endpoint: FIBROLIV – Fibrosis of liver
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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