Toxic Nodular Goiter: Nodular enlargement of the thyroid gland associated with hyperthyroidism.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2647 |
4. Check minimum number of eventsNone |
2647 |
5. Include endpointsNone |
2647 |
6. Filter based on genotype QC (FinnGen only) |
2403 |
Control definitions (FinnGen only)
- Control exclude
- THYROTOXICOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis cum struma multinodulari
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis with toxic multinodular goitre
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Benign thyroid growths and nodules
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18329 | 15393 | 2783 |
| Only index persons | 14535 | 12435 | 2100 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.38 | 0.44 | 0.08 |
| Only index persons | 0.40 | 0.46 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 60.94 | 60.51 | 63.51 |
| Only index persons | 60.38 | 59.55 | 65.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2403 | 1949 | 454 |
| Unadjusted period prevalence (%) | 0.60 | 0.69 | 0.21 |
| Median age at first event (years) | 62.23 | 60.84 | 68.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2463
- Matched controls
- 24630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
338.9
307.7
298
10
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
1352.7
307.7
754
8
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
18.9
307.7
268
158
104
Kela drug reimbursment
Thyroid insufficiency
7.7
307.7
705
1212
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
65.7
307.7
254
43
H03BB01
ATC
carbimazole; oral
865.4
307.7
1582
51
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
32.7
307.7
443
164
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
10.0
307.7
465
559
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
100.2
307.7
194
21
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
8459.9
307.7
2088
8
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
134.2
307.7
209
17
BAA60
NOMESCO Finland
Total thyroidectomy
37.2
307.7
588
206
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
+∞
307.7
326
*
H03AA01
ATC
levothyroxine sodium; systemic
6.4
307.7
1482
4697
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
7920.4
307.7
613
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
9.2
193.2
245
291
T85
ICPC
Hyperthyroidism/thyrotoxicosis
31.8
190.2
124
41
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
9.5
133.6
163
183
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
43.7
113.9
68
16
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.2
110.0
320
839
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
17.2
80.8
67
40
T86
ICPC
Hypothyroidism/myxoedema
3.8
78.3
255
720
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
76.4
73
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.0
75.7
230
618
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
9.5
69.5
83
90
C07AA05
ATC
propranolol; systemic
2.3
68.1
640
3208
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
68.0
65
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.4
65.1
554
2653
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
16.2
63.3
54
34
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
21.8
63.1
47
22
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
4.9
60.5
137
292
T81
ICPC
Goitre
13.7
58.9
55
41
2422A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic multinodular goitre
+∞
57.5
55
*
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
9.6
53.5
63
67
A11CC03
ATC
alfacalcidol; systemic
5.0
53.0
116
240
C07AB07
ATC
bisoprolol; oral
1.9
52.8
1435
10371
E03
ICD-10 Finland
Other hypothyroidism
2.7
44.0
256
1012
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.8
43.3
138
381
E05.89
ICD-10 Finland
Other thyrotoxicosis
223.9
43.0
44
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.2
41.1
86
171
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
37.9
1152
8290
WX402
NOMESCO Finland
General anaesthesia
1.9
35.9
597
3587
BA1AE, ,
SPAT
6.1
34.6
60
100
E04.8
ICD-10 Finland
Other specified nontoxic goitre
11.5
31.8
33
29
E83.51
ICD-10 Finland
Hypocalcemia
7.2
31.0
46
65
106
Kela drug reimbursment
Hypoparathyroidism
9.0
30.7
38
43
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
4.1
30.6
86
217
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
26.8
27.1
37
14
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
26.2
596
3879
H062, E050,
ICD-10 Finland
+∞
25.0
24
*
E04
ICD-10 Finland
Other nontoxic goitre
8.7
24.5
31
36
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
4.4
24.1
60
138
24209
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffuse NUD
+∞
22.9
22
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
22.9
488
3107
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
22.7
447
2781
207
Kela drug reimbursment
Chronic arrhythmias
1.7
22.7
466
2936
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
22.7
917
6822
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
8.8
22.4
28
32
H03BA02
ATC
propylthiouracil; oral
+∞
21.9
21
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
21.3
958
7263
R06.0
ICD-10 Finland
Dyspnoea
1.6
20.8
747
5389
ZXA10
NOMESCO Finland
Bilateral
1.6
20.7
514
3395
Z3231
NOMESCO Finland
Registered nurse
1.6
20.3
672
4753
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
201.6
19.6
20
*
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
5.6
19.1
36
65
24200
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffusa et exophthalmo. Morbus Basedowi
+∞
18.8
18
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
17.8
520
3561
GB1AA
NOMESCO Finland
Tracheal X-ray examination
29.0
17.4
23
8
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
5.4
17.3
34
64
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
3.8
17.3
53
143
R4110
NOMESCO Finland
Physiotherapy
1.5
17.0
706
5210
B01AA03
ATC
warfarin; systemic
1.6
17.0
470
3173
Z71.8
ICD-10 Finland
Other specified counselling
1.5
16.7
811
6172
Z2221
NOMESCO Finland
Medical doctor
1.5
16.3
654
4784
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
3.9
16.3
48
126
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
16.3
398
2605
ZXE00
NOMESCO Finland
One hour or less
1.4
16.1
915
7163
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
18.6
16.0
24
13
N02BE01
ATC
paracetamol; systemic, rectal
1.8
15.8
2216
20584
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
1.9
15.7
225
1269
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
1.8
15.5
245
1424
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
15.0
454
3122
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
14.9
598
4364
TFP20
NOMESCO Finland
Cardiodefibrillation
1.9
14.9
180
959
24220
ICD-8 Finland
Thyrotoxicosis with or without goitre, Thyrotoxicosis without mention of goitre
+∞
14.6
14
*
R53
ICD-10 Finland
Malaise and fatigue
1.5
14.5
637
4729
R00.2
ICD-10 Finland
Palpitations
1.8
14.4
211
1197
C03CA01
ATC
furosemide; systemic
1.4
14.2
835
6536
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
14.1
1597
13962
B01AF02
ATC
apixaban; oral
1.6
14.1
374
2491
R03BB04
ATC
tiotropium bromide; inhalant
1.7
13.4
251
1528
A12AA04
ATC
calcium carbonate; oral
3.4
13.2
46
136
Z01.7
ICD-10 Finland
Laboratory examination
1.5
12.9
407
2815
24400
ICD-8 Finland
Myxoedema, (hypothyreosis) post therapiam
32.2
12.6
16
5
E05.5
ICD-10 Finland
Thyroid crisis or storm
+∞
12.5
12
*
H05.2
ICD-10 Finland
Exophthalmic conditions
17.4
12.5
19
11
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.7
12.0
213
1277
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.3
11.6
86
380
C07AA07
ATC
sotalol; systemic
2.2
11.6
99
465
C07AB02
ATC
metoprolol; systemic
1.4
11.3
513
3809
A04
ICPC
Weakness/tiredness general
1.5
11.3
404
2866
ZXA05
NOMESCO Finland
Left side
1.4
11.1
604
4631
K78
ICPC
Atrial fibrillation/flutter
1.7
11.0
203
1232
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
3.4
11.0
38
112
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
10.7
707
5588
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
2.9
10.6
49
172
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
10.5
1164
9939
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
10.4
10
*
BA1AN
NOMESCO Finland
Thyroid gland isotope imaging
+∞
10.4
10
*
C01BD01
ATC
amiodarone; systemic
2.5
10.4
65
267
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.0
10.4
104
520
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.6
10.3
270
1789
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
13.2
10.1
17
13
B01AB05
ATC
enoxaparin; parenteral
1.3
10.0
780
6312
K80
ICPC
Cardiac arrhythmia NOS
1.6
9.7
229
1479
XF404
NOMESCO Finland
Ambulatory ECG
1.6
9.6
202
1268
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
15.1
9.5
15
10
H02AB06
ATC
prednisolone; systemic
1.3
9.5
1109
9487
L28
ICPC
Limited function/disability (L)
1.4
9.5
524
4013
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
3.0
9.5
41
139
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
9.3
823
6767
EP1AE, ,
SPAT
2.6
9.3
53
208
A02BC02
ATC
pantoprazole; systemic
1.3
9.2
1673
15160
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.4
9.2
576
4499
A10BH05
ATC
linagliptin; oral
1.8
9.2
130
731
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.4
9.1
436
3254
A11CC02
ATC
dihydrotachysterol; oral
7.7
9.1
20
26
C01AA05
ATC
digoxin; systemic
1.6
9.0
205
1312
C03DA01
ATC
spironolactone; oral
1.5
9.0
306
2142
C08CA01
ATC
amlodipine; oral
1.3
8.9
975
8247
J01DB01
ATC
cefalexin; oral
1.4
8.8
1908
17672
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
8.8
499
3836
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
1.9
8.7
105
560
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
1.9
8.7
99
518
I48.1
ICD-10 Finland
Persistent atrial fibrillation
1.9
8.7
112
611
J01DA01
ATC
[U] cefalexin
1.3
8.6
1404
12481
XF600
NOMESCO Finland
Bloodpressure measurement
1.7
8.6
140
822
E21.0
ICD-10 Finland
Primary hyperparathyroidism
2.3
8.4
64
287
Z3226
NOMESCO Finland
Physiotherapist
1.4
8.4
415
3114
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.5
8.4
300
2122
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.4
8.3
449
3419
205
Kela drug reimbursment
Chronic hypertension
1.3
8.2
652
5262
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
1.9
8.2
105
572
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
4.2
8.2
21
50
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
8.1
1149
10008
TPH07
NOMESCO Finland
Cathetrisation of artery
1.5
8.0
254
1751
T90
ICPC
Diabetes non-insulin dependent
1.3
8.0
558
4419
A10BA02
ATC
metformin; oral
1.3
8.0
645
5219
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.4
8.0
468
3611
A27
ICPC
Fear of other disease NOS
1.7
7.8
127
745
R4130
NOMESCO Finland
Speech therapy
2.2
7.8
65
304
G47.3
ICD-10 Finland
Sleep apnoea
1.4
7.7
430
3291
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
1.8
7.6
107
601
A02BC05
ATC
esomeprazole; systemic
1.3
7.5
954
8171
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.5
7.5
226
1544
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
7.5
661
5406
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
2.3
7.4
55
245
WW200
NOMESCO Finland
Immunization
2.3
7.3
55
246
R02
ICPC
Shortness of breath/dyspnoea
1.4
7.3
331
2444
E05.3
ICD-10 Finland
Thyrotoxicosis from ectopic thyroid tissue
+∞
7.3
7
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
2.8
7.3
34
121
A91
ICPC
Abnormal result investigation NOS
1.7
7.3
132
799
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.3
7.3
533
4246
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.4
7.3
353
2638
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
7.2
507
4011
XCK10
NOMESCO Finland
Photography of fundus of eye
1.5
7.2
216
1472
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
5.8
7.2
19
33
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
7.2
955
8217
M03BX02
ATC
tizanidine; oral
1.3
7.1
1355
12148
E83.50
ICD-10 Finland
Hypercalcemia
2.5
7.1
43
175
R13
ICD-10 Finland
Dysphagia
1.6
7.1
170
1104
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.3
7.0
586
4749
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.3
7.0
480
3783
K85
ICPC
Elevated blood pressure
1.3
7.0
446
3479
R03AC02
ATC
salbutamol; inhalant
1.3
7.0
1241
11028
M04AA01
ATC
allopurinol; systemic
1.4
6.9
264
1890
K04
ICPC
Palpitations/awareness of heart
1.7
6.9
131
803
R21
ICPC
Throat symptom/complaint
1.4
6.9
384
2934
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
3.3
6.8
25
77
A10BK03
ATC
empagliflozin; oral
1.5
6.8
224
1558
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
11.0
6.8
12
11
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.5
6.8
200
1360
BWD00
NOMESCO Finland
Reoperation for deep haemorrhage in endocrine surgery
40.2
6.8
8
*
J45.1
ICD-10 Finland
Nonallergic asthma
1.6
6.7
167
1093
J01MA02
ATC
ciprofloxacin; systemic
1.3
6.7
851
7262
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
1.6
6.7
146
926
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
1.7
6.7
125
763
UDQ12
NOMESCO Finland
Flexible laryngoscopy
1.7
6.7
124
756
NE1AA
NOMESCO Finland
Pelvis X-ray examination
1.5
6.6
201
1374
2504
FHL
Unilateral resection or enucleation
2.9
6.6
30
105
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.5
6.6
200
1368
C09AA02
ATC
enalapril; systemic
1.3
6.6
436
3418
J01AA02
ATC
doxycycline; systemic
1.3
6.6
1840
17170
M79.6
ICD-10 Finland
Pain in limb
1.2
6.6
1036
9061
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.3
6.5
522
4201
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.5
6.5
179
1199
Z71
ICD-10 Finland
Persons encountering health services for other counselling and medical advice, not elsewhere classified
2.0
6.5
69
355
H03BB02
ATC
thiamazole; oral
70.0
6.4
7
*
ZXE20
NOMESCO Finland
More than three and less than five hours
1.4
6.4
279
2044
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
2.0
6.4
63
315
I50.0
ICD-10 Finland
Congestive heart failure
1.5
6.4
179
1204
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
6.4
663
5520
C03AA03
ATC
hydrochlorothiazide; oral
1.5
6.4
233
1655
ZX114
NOMESCO Finland
Intramuscular
2.7
6.3
33
125
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
+∞
6.3
6
*
J01FA10
ATC
azithromycin; systemic
1.2
6.2
1220
10902
E20.8
ICD-10 Finland
Other hypoparathyroidism
26.7
6.2
8
*
2411A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic multinodular goitre
3.5
6.2
20
57
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
2.5
6.1
37
151
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.3
6.0
563
4622
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1388
1162
26.08
307.65
5.6
2.5
4.84
4.32
pmol/l
37.77
1308
1001
1152
365
58.42
307.65
1.9
1.5
19.87
22.46
iu/l
0.04
391
114
653
1408
5.95
300.19
1.3
1.2
94.82
123.85
u/ml
0.89
205
499
2273
17428
4.94
114.79
13.8
4.6
15.79
14.93
pmol/l
47.70
2199
15863
268
633
4.63
105.34
1.2
1.3
—
—
—
0
0
535
2138
2.92
94.08
3.4
3.5
72.02
86.85
ng/l
2.65
473
1787
1769
12544
2.46
86.38
8.7
7.0
1.21
1.22
mmol/l
2.07
1570
10781
1580
11282
2.12
66.79
7.7
6.3
1.21
1.22
mmol/l
2.34
1508
10325
1700
12988
2.00
53.12
9.6
9.7
4.01
4.05
e9/l
0.33
1450
11225
2297
20145
3.08
46.06
15.6
5.8
1.47
1.98
mu/l
43.62
2223
18479
94
201
4.82
41.27
4.5
5.3
186.93
48.23
u/ml
0.83
23
65
1459
11250
1.73
36.99
2.9
2.5
77.52
80.34
nmol/l
3.79
1336
10030
1287
9902
1.63
30.18
12.8
11.8
0.00
0.00
e9/l
1.62
1021
8017
1948
16762
1.78
28.75
4.9
4.7
13.59
13.68
mm/h
0.10
1856
15568
63
133
4.83
28.11
5.8
6.8
114.14
159.25
ug/l
0.12
43
76
1348
10757
1.56
25.07
6.4
6.3
26.64
27.43
%
1.97
1266
10140
1457
11851
1.56
24.73
6.3
6.3
0.19
0.19
e9/l
0.16
1255
10190
1011
7603
1.56
24.24
4.1
3.4
82.81
63.27
e6/l
0.18
754
5768
1325
10583
1.55
24.16
6.2
6.2
58.48
57.57
%
2.18
1255
10033
819
5881
1.59
23.96
4.5
3.9
88.49
90.67
%
1.63
804
5749
1151
8964
1.53
23.22
3.7
3.6
2.35
2.36
mmol/l
2.15
1062
8068
1618
13571
1.56
23.16
5.8
4.8
6.75
6.68
mmol/l
0.75
1564
12900
1118
8673
1.53
22.83
5.0
4.1
88.42
110.89
e6/l
0.69
786
6012
1426
11687
1.52
22.25
6.2
6.2
1.80
1.89
e9/l
1.80
1220
10151
1982
17521
1.67
22.00
9.4
8.4
79.33
80.22
u/l
0.51
1916
16500
887
6623
1.53
21.18
3.9
3.3
0.34
0.50
e6/l
2.15
639
4838
556
3762
1.62
20.30
3.5
3.1
3.79
3.29
e6/l
0.38
268
1791
788
5801
1.53
19.79
2.4
2.4
—
—
—
0
0
1339
10987
1.48
19.65
20.8
15.3
1.33
1.26
inr
4.16
1120
9106
480
3168
1.64
19.26
5.4
5.3
1.04
1.04
mmol/l
0.06
438
2900
1302
10663
1.47
19.03
2.9
2.8
—
—
estimate
—
0
0
997
7810
1.46
18.01
3.5
3.2
1394.88
1393.64
ng/l
0.00
886
6756
1329
11013
1.45
17.72
5.1
4.9
35.17
35.29
g/l
0.35
1260
10267
1924
17161
1.55
17.59
29.1
21.7
13.83
13.77
%
1.19
1902
16913
412
2692
1.64
17.02
2.5
2.6
6.75
7.82
umol/l
0.75
357
2346
646
4687
1.51
16.87
4.7
4.0
156.74
295.79
ng/l
1.88
531
3789
578
4130
1.52
16.12
3.5
2.9
1.00
1.39
e6/l
1.56
295
2172
581
4209
1.50
15.03
1.9
1.9
—
—
—
0
0
567
4091
1.50
14.95
3.2
3.1
0.79
0.82
mmol/l
5.80
534
3814
2245
21048
1.75
13.96
21.8
17.4
23.84
23.96
mg/l
0.06
1984
17525
430
2977
1.54
13.64
1.9
1.9
—
—
—
0
0
240
1437
1.74
13.64
8.7
8.1
25.19
24.42
mmol/l
2.83
240
1408
560
4108
1.47
13.40
2.7
2.6
12.27
12.31
umol/l
0.03
527
3808
493
3527
1.50
13.37
2.6
2.6
21.04
21.41
%
0.23
457
3252
451
3170
1.52
13.31
1.9
1.8
—
—
—
0
0
526
3826
1.48
13.11
2.6
2.5
2.32
2.32
g/l
0.03
484
3509
340
2257
1.59
12.94
2.4
2.4
32.24
37.65
u/l
1.53
282
1895
698
5369
1.42
12.86
3.2
3.1
2.46
2.47
mmol/l
0.74
613
4837
70
270
2.64
12.63
1.6
1.6
26.69
28.07
ng/l
0.07
70
270
338
2274
1.56
12.10
2.3
2.2
377.07
382.68
nmol/l
0.20
317
2087
101
475
2.17
11.75
2.2
2.0
4.67
4.79
mmol/24h
0.15
94
406
252
1595
1.65
11.62
1.9
1.7
—
—
—
0
0
2170
20332
1.57
11.52
22.8
17.3
76.17
76.14
ml/min/173m2
0.03
2061
18954
681
5309
1.39
11.36
3.3
2.7
5.94
6.69
e6/l
0.84
611
4810
79
347
2.32
10.85
1.7
1.5
32.69
32.17
g/l
0.14
70
317
140
768
1.87
10.64
1.7
2.3
0.00
0.00
g/l
-0.00
124
670
304
2054
1.55
10.63
4.3
3.8
1.23
1.23
mmol/l
0.70
270
1760
1419
12446
1.33
10.63
6.3
6.6
10.77
11.17
umol/l
1.04
1366
11820
1276
11025
1.33
10.60
2.4
2.2
95.56
96.99
pmol/l
0.48
683
5421
391
2792
1.48
10.50
7.4
6.9
1.56
1.15
mmol/l
1.25
344
2300
132
714
1.90
10.48
1.7
2.3
0.00
0.00
g/l
-0.00
124
669
2285
21754
1.70
10.46
26.9
20.9
139.83
139.65
mmol/l
2.87
2261
21323
144
802
1.84
10.44
1.7
2.3
0.02
0.03
g/l
0.21
130
720
333
2313
1.51
10.23
8.1
7.7
120.37
118.81
g/l
0.74
328
2259
1698
15329
1.35
10.22
6.4
5.4
4066.56
2545.24
e6/l
0.20
30
212
2286
21787
1.69
10.14
27.2
21.1
3.95
3.97
mmol/l
2.72
2258
21313
392
2820
1.46
10.11
7.4
7.0
11.98
12.38
kpa
0.84
384
2705
478
3568
1.42
10.10
2.1
2.0
29.96
29.50
s
0.84
467
3458
124
667
1.90
10.03
3.1
3.5
1.29
2.15
index
1.24
63
331
391
2821
1.46
9.92
7.4
7.0
5.30
5.11
kpa
2.28
385
2705
350
2471
1.49
9.92
7.7
7.3
94.76
95.55
%
1.00
344
2387
573
4438
1.38
9.71
1.5
1.5
2.28
2.43
g/l
1.02
321
2555
2181
20601
1.51
9.59
6.0
5.6
6.07
5.95
mmol/l
4.61
2018
18684
293
2008
1.52
9.57
3.3
3.0
264.79
208.74
ng/l
0.94
261
1843
2141
20159
1.47
9.44
7.9
6.9
40.20
39.56
mmol/mol
2.86
2007
18641
2299
21995
1.68
9.38
15.5
13.0
23.64
23.98
u/l
0.44
2264
21277
340
2413
1.47
9.36
4.1
3.4
5.95
5.81
kpa
1.52
334
2356
330
2334
1.48
9.24
4.1
3.4
2.43
1.96
mmol/l
1.35
298
2048
1204
10439
1.30
9.23
3.6
3.1
114.86
118.78
ug/l
0.27
1126
9630
69
308
2.28
9.18
1.8
1.4
1525.05
1713.12
e6/l
0.25
44
210
62
265
2.37
9.11
1.7
1.4
27099.58
78202.94
e6/l
0.84
31
135
787
6451
1.32
9.08
3.7
3.4
0.00
0.04
1.91
22
210
640
5093
1.35
9.03
1.9
1.7
1.29
1.32
mg/l
0.11
511
3988
113
615
1.88
8.85
3.5
3.5
0.81
0.80
nmol/l
0.08
95
506
786
6462
1.32
8.82
2.6
2.4
2.88
2.93
mg/l
0.25
689
5559
2215
21062
1.51
8.65
6.6
6.2
2.63
2.69
mmol/l
2.87
2083
19299
159
968
1.69
8.52
1.7
2.4
0.31
1.05
g/l
4.38
136
822
1831
16884
1.33
8.45
30.3
23.0
329.76
330.53
g/l
3.45
1822
16784
952
8073
1.29
8.38
3.5
3.3
6.59
6.62
mmol/l
0.08
781
6713
95
499
1.94
8.29
1.3
1.3
—
—
—
0
0
95
499
1.94
8.29
1.3
1.3
—
—
—
0
0
44
170
2.62
8.02
3.5
2.7
18.80
31.50
mg/l
2.00
35
123
1323
11733
1.28
8.01
2.9
2.7
—
—
—
0
0
154
947
1.67
7.96
1.8
2.4
9.71
10.20
g/l
0.66
135
823
303
2169
1.45
7.94
2.3
2.8
64.51
66.25
g/l
3.90
275
1968
94
500
1.91
7.92
1.4
1.4
—
—
—
0
0
2310
22228
1.63
7.91
29.5
23.3
76.77
75.05
umol/l
1.51
2298
21939
869
7325
1.29
7.89
3.3
3.2
28.62
33.89
u/l
2.44
825
6884
939
7996
1.28
7.86
4.3
4.0
10.02
8.50
mg/mmol
0.34
567
4651
147
898
1.68
7.80
1.9
3.4
110.54
46.37
mg/l
0.40
129
779
643
5214
1.32
7.79
1.3
1.3
1.38
1.41
u/ml
0.03
154
1334
369
2751
1.40
7.71
4.1
4.1
230.85
246.09
u/l
1.54
345
2595
2172
20660
1.43
7.58
5.6
5.4
4.58
4.69
mmol/l
5.99
2051
18983
146
898
1.67
7.56
1.9
3.4
49.94
120.49
mg/l
0.63
129
780
165
1047
1.62
7.55
1.8
2.4
3.13
2.94
g/l
1.70
146
933
1347
12064
1.26
7.13
4.6
4.4
0.00
0.00
estimate
0.50
295
2545
2156
20523
1.41
7.09
5.5
5.3
1.49
1.54
mmol/l
7.60
2012
18732
2328
22508
1.63
7.01
35.1
26.8
256.27
254.69
e9/l
0.58
2298
22028
2328
22510
1.62
6.98
35.0
26.7
91.12
91.49
fl
3.48
2315
22239
131
801
1.67
6.95
1.9
3.2
1.37
4.00
ratio
2.36
77
468
2328
22512
1.62
6.95
35.8
27.2
39.76
39.40
%
2.55
2316
22231
2328
22512
1.62
6.95
35.1
26.7
4.44
4.37
e12/l
9.29
2286
21944
2328
22513
1.62
6.93
35.2
26.8
6.80
6.69
e9/l
1.23
2290
21943
2328
22516
1.62
6.89
35.4
27.0
132.49
131.53
g/l
2.82
2317
22253
170
1112
1.57
6.87
1.8
2.3
3.61
3.67
g/l
0.24
152
999
2072
19620
1.35
6.85
4.6
4.5
1.29
1.27
mmol/l
0.54
1908
17676
170
1113
1.57
6.84
1.8
2.3
7.54
7.54
g/l
0.02
151
999
170
1113
1.57
6.84
1.8
2.3
4.07
4.24
g/l
2.39
152
998
285
2076
1.42
6.78
7.3
6.6
10.73
10.15
mmol/l
0.57
265
1989
693
5767
1.28
6.74
2.9
2.7
346.69
333.99
umol/l
2.21
593
4987
219
1525
1.48
6.61
10.2
8.2
0.61
0.64
%
0.65
219
1515
1356
12215
1.24
6.58
4.7
4.4
0.00
3.46
estimate
1.83
307
2655
258
1858
1.43
6.54
1.7
1.7
—
—
—
0
0
36
140
2.59
6.54
1.2
1.2
34.21
17.32
u/l
0.67
29
117
84
460
1.86
6.54
1.7
1.7
244.86
312.23
mu/l
2.43
79
416
1366
12322
1.24
6.52
4.7
4.4
0.00
0.13
estimate
0.52
281
2508
872
7508
1.25
6.28
2.8
2.6
59.27
71.67
u/l
0.58
814
6914
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
121
748
1.65
6.19
2.4
2.7
0.37
0.38
iu/ml
0.01
67
428
65
336
1.96
6.04
1.2
1.3
0.20
0.24
nmol/l
0.28
51
258
54
261
2.09
6.02
1.3
1.2
75.09
55.90
u/l
1.16
46
232
73
393
1.88
6.02
1.2
1.3
0.50
0.53
nmol/l
—
5
16
1033
9096
1.23
5.97
4.5
4.1
100.01
100.53
ng/l
0.00
749
6683
42
184
2.30
5.95
2.5
1.6
95.59
98.40
ng/l
0.06
42
184
1492
13671
1.23
5.83
3.5
3.3
45.89
49.55
u/l
0.88
1411
12610
222
1591
1.43
5.79
10.1
8.1
93.38
93.82
%
0.35
222
1582
35
143
2.47
5.78
1.2
1.2
94.17
73.51
u/l
0.42
29
123
210
2888
0.70
5.64
8.6
7.2
—
—
—
0
0
77
431
1.81
5.64
1.3
1.3
—
—
—
0
0
24
84
2.88
5.35
1.6
1.5
0.40
0.40
ug/l
0.01
16
52
36
157
2.31
5.19
1.3
1.1
388.57
108.85
titre
—
7
26
102
635
1.63
5.13
1.7
1.6
—
—
—
0
0
163
1138
1.46
4.91
1.6
1.7
1.69
1.59
g/l
0.86
146
983
309
2448
1.30
4.28
3.6
3.5
—
—
—
0
0
57
319
1.81
4.26
1.3
1.3
329.69
315.45
pmol/l
0.10
50
268
58
332
1.77
4.04
1.3
1.2
18.89
14.24
u/l
1.14
50
260
43
225
1.93
3.97
1.3
1.2
—
—
—
0
0
20
78
2.58
3.71
1.3
1.2
5.78
11.64
pmol/l
—
5
30
827
7380
1.18
3.66
1.8
1.7
20.00
21.08
nmol/l
1.29
719
6132
243
1919
1.30
3.47
2.9
2.4
0.27
0.51
e6/l
2.22
237
1828
709
6278
1.18
3.40
4.3
3.8
0.04
0.29
estimate
0.82
228
2004
656
5774
1.19
3.37
4.0
4.2
0.33
0.15
0.31
12
77
81
534
1.53
3.31
1.3
1.2
—
—
—
0
0
383
3210
1.23
3.30
1.5
1.5
—
—
—
0
0
847
7630
1.17
3.26
2.2
2.2
171.17
201.35
u/l
0.58
800
7181
79
520
1.54
3.26
1.5
1.6
—
—
—
0
0
31
157
1.99
3.19
1.6
1.7
—
—
—
0
0
227
1804
1.28
3.11
4.0
3.4
0.67
0.79
ug/l
2.08
172
1221
19
80
2.39
3.06
2.0
1.5
76.47
430.90
nmol/24h
0.51
19
80
47
281
1.69
2.90
1.7
1.5
47.48
58.12
%
0.82
29
177
335
2817
1.22
2.80
3.3
4.2
4.51
20.67
ug/l
3.31
276
2288
117
861
1.38
2.75
1.9
1.8
—
—
—
0
0
27
138
1.97
2.75
2.2
2.3
11.61
8.62
mmol/l
0.89
27
138
113
827
1.38
2.75
1.3
1.3
—
—
—
0
0
1008
9286
1.14
2.74
2.1
1.9
1.34
1.32
mmol/l
0.32
820
7713
243
2956
0.80
2.71
5.3
5.3
33.63
33.59
%
0.02
178
1854
192
1526
1.28
2.66
3.2
2.9
129.70
126.94
g/l
1.13
187
1483
43
691
0.62
2.60
1.4
1.5
—
—
—
0
0
42
253
1.67
2.55
2.9
3.4
12.55
11.78
index
0.11
22
126
287
2410
1.22
2.45
2.1
2.2
0.21
0.21
g/l
0.02
267
2253
123
931
1.34
2.45
2.0
1.9
—
—
—
0
0
87
625
1.41
2.40
2.5
3.0
1.68
1.60
mg/l
0.40
79
563
15
64
2.35
2.38
1.1
1.2
116.80
111.73
%
0.41
15
55
336
2873
1.20
2.38
2.1
2.1
139.58
136.37
ug/g
0.06
275
2235
266
2226
1.22
2.36
2.4
2.5
72.33
69.71
e9/l
0.56
185
1625
20
98
2.05
2.31
1.3
1.4
6.04
5.95
mmol/l
0.08
20
92
498
4416
1.16
2.27
1.8
1.8
1130.71
1179.90
nmol/l
0.55
400
3267
105
789
1.35
2.22
1.3
1.5
275.09
280.54
ug/g
0.09
56
450
10
35
2.86
2.20
1.5
1.6
—
—
—
0
0
87
636
1.38
2.19
1.5
1.4
—
—
—
0
0
59
403
1.48
2.15
2.3
1.8
1.11
0.82
nmol/l
1.42
51
334
36
220
1.65
2.12
1.1
1.2
113.97
107.27
pmol/l
0.29
36
220
8
25
3.21
2.09
11.0
15.3
4.56
4.90
mmol/l
—
8
25
170
1379
1.25
2.04
1.5
1.9
1.17
1.40
g/l
1.18
161
1252
108
827
1.32
2.04
2.6
2.7
—
—
—
0
0
83
611
1.37
2.03
1.9
1.6
11964.55
13237.77
e6/l
0.13
56
424
159
1284
1.25
1.99
3.0
2.5
1.22
1.14
%
0.56
159
1276
154
1240
1.26
1.98
1.5
1.5
—
—
—
0
0
124
973
1.29
1.97
3.2
3.4
242.81
1817.91
u/ml
0.88
104
827
21
112
1.88
1.96
1.3
2.0
263.50
194.29
e6/l
0.64
14
97
34
210
1.63
1.95
1.8
1.5
26.50
34.25
%
0.49
20
130
36
226
1.60
1.93
1.1
1.1
—
—
—
0
0
157
1272
1.25
1.92
3.0
2.5
0.58
0.63
%
1.36
157
1265
78
574
1.37
1.92
2.0
2.1
131.05
125.80
g/l
1.12
55
441
95
722
1.33
1.91
1.4
1.6
1.16
1.19
g/l
0.45
89
686
570
5165
1.13
1.89
1.9
1.8
48729242.73
28656809.52
pmol/l
0.30
472
4205
123
970
1.28
1.89
1.7
1.8
8.25
7.63
iu/ml
0.11
20
229
5
12
4.17
1.82
1.2
1.0
—
—
—
0
0
12
53
2.27
1.80
1.3
1.2
—
—
—
0
0
238
2027
1.19
1.80
2.6
2.4
5.52
6.42
ug/l
0.35
210
1750
92
703
1.32
1.79
1.3
1.6
0.23
0.24
g/l
0.09
86
668
27
161
1.68
1.78
1.0
1.0
301.07
293.88
mg/l
0.22
27
138
84
637
1.33
1.74
1.2
1.2
—
—
—
0
0
11
48
2.30
1.70
1.1
1.2
120.32
139.00
pmol/l
0.23
11
48
83
633
1.32
1.66
1.2
1.2
—
—
—
0
0
7
25
2.80
1.65
2.6
2.7
1.29
0.80
u/field
—
7
25
17
91
1.87
1.60
1.1
2.7
70.75
154.52
umol/l
—
8
56
20
113
1.78
1.60
2.1
1.8
1.50
2.58
u/field
0.54
12
80
282
2466
1.16
1.58
5.0
4.8
21.32
21.74
%
0.19
140
1263
28
175
1.61
1.57
1.3
1.2
—
—
titre
—
0
0
165
1379
1.21
1.56
1.2
1.3
65.87
51.93
au/ml
—
8
100
14
72
1.95
1.48
1.2
1.3
23.73
447.58
ug/l
—
6
37
72
549
1.32
1.47
1.4
1.3
—
—
—
0
0
455
4131
1.12
1.47
1.3
1.3
12.59
12.50
u/ml
0.01
156
1512
110
888
1.25
1.45
2.1
2.1
299.95
769.25
ug/l
1.18
101
839
146
1217
1.21
1.43
1.8
1.9
—
—
—
0
0
178
1516
1.19
1.40
2.3
2.5
29.59
23.49
au/ml
0.23
11
129
9
41
2.20
1.37
1.8
2.8
15.56
14.43
ml/dl
—
9
36
86
681
1.27
1.35
1.5
1.5
0.09
9.33
iu/ml
0.50
18
131
217
1886
1.17
1.34
1.8
1.7
1.50
1.46
%
0.32
182
1616
209
1812
1.17
1.33
1.5
1.5
—
—
—
0
0
10
47
2.13
1.33
1.1
1.1
1.18
1.17
mmol/l
—
10
47
11
54
2.04
1.32
1.0
1.6
94.50
89.67
%
—
6
30
87
693
1.26
1.31
2.4
2.3
10.35
11.42
nmol/l
0.54
78
608
93
748
1.25
1.30
1.8
1.7
—
—
—
0
0
23
145
1.59
1.29
1.1
1.3
9.86
9.18
mmol/l
0.27
23
136
343
3088
1.13
1.28
6.6
5.9
3.46
3.21
ug/l
0.10
298
2712
36
251
1.44
1.28
3.2
3.7
—
—
—
0
0
43
310
1.39
1.28
1.4
1.4
161.71
163.47
au/ml
0.04
17
94
200
1735
1.17
1.28
2.3
2.9
10.22
10.54
g/l
0.42
182
1585
17
99
1.72
1.27
1.1
1.1
—
—
—
0
0
25
162
1.55
1.26
1.8
1.5
2.95
7.13
u/l
2.04
19
132
89
716
1.25
1.25
1.8
1.8
—
—
—
0
0
151
1285
1.19
1.22
3.7
3.7
2.63
2.09
mmol/l
0.85
123
971
5
19
2.63
1.21
1.0
1.1
128.00
77.47
titre
—
5
19
946
8988
1.09
1.20
4.7
4.4
0.01
0.35
estimate
0.76
225
2044
153
1308
1.18
1.18
3.7
3.8
1.02
1.02
ratio
0.33
131
1192
62
481
1.30
1.17
2.1
2.3
42.66
99.28
ug/min
1.85
37
272
10
50
2.00
1.16
1.1
1.2
—
—
—
0
0
30
207
1.45
1.15
2.2
2.2
2.65
1.81
u/field
0.50
17
106
131
1110
1.19
1.13
4.2
3.2
26.13
25.51
mmol/l
1.38
126
1076
34
243
1.40
1.09
1.3
1.3
51.27
34.11
u/l
1.38
29
202
175
1524
1.16
1.09
3.8
3.8
5.26
5.19
kpa
0.41
168
1460
18
112
1.61
1.08
1.3
1.9
451.45
438.95
e6/l
0.02
11
91
82
669
1.23
1.05
1.2
1.3
3.51
5.60
u/ml
—
9
118
132
1131
1.18
1.02
1.0
1.1
—
—
—
0
0
128
1095
1.18
1.01
1.8
1.8
—
—
—
0
0
188
1657
1.15
1.01
3.4
3.9
100.94
78.97
u/ml
0.13
183
1598
10
53
1.89
1.01
1.0
1.2
99.00
84.68
%
—
5
28
5
23
2.18
0.98
1.2
1.1
—
—
—
0
0
17
109
1.56
0.93
1.0
1.1
—
—
—
0
0
22
150
1.47
0.93
1.1
1.2
—
—
—
0
0
474
4423
1.09
0.92
1.4
1.3
35.07
34.76
iu/ml
0.02
137
1367
23
159
1.45
0.91
1.3
1.3
—
—
—
0
0
22
151
1.46
0.90
1.1
1.1
15.30
10.79
iu/ml
—
5
44
20
135
1.49
0.89
1.6
1.5
80.65
79.18
umol/l
0.11
20
135
114
980
1.17
0.88
1.9
1.9
36.93
39.67
u/l
0.80
101
869
17
111
1.54
0.87
2.6
2.2
—
177.14
—
0
21
23
161
1.43
0.86
1.3
1.3
—
—
—
0
0
38
290
1.32
0.86
1.3
1.4
277.28
274.77
mosm/kgh2o
0.35
32
218
80
669
1.20
0.85
1.1
1.3
1.68
2.83
u/ml
—
5
70
31
230
1.35
0.85
1.4
1.5
—
—
—
0
0
17
112
1.52
0.85
1.4
1.2
—
—
—
0
0
17
112
1.52
0.85
1.4
1.2
—
—
—
0
0
14
88
1.59
0.84
1.2
1.3
131.50
152.76
mmol/24h
0.45
14
88
164
1455
1.14
0.84
1.3
1.3
141.65
188.60
u/ml
0.62
150
1334
37
284
1.31
0.82
1.1
1.1
—
—
—
0
0
90
766
1.18
0.80
1.3
1.3
—
—
—
0
0
70
582
1.21
0.80
1.6
1.7
—
—
—
0
0
37
285
1.30
0.80
1.2
1.2
5.64
2.54
u/ml
0.33
14
84
0
25
0.00
0.79
0.0
1.0
—
0.41
—
0
15
78
657
1.19
0.78
3.3
3.1
1.82
1.57
mmol/l
0.88
78
642
66
547
1.21
0.78
2.2
3.4
168.47
996.17
u/ml
0.96
56
496
0
26
0.00
0.78
0.0
1.0
—
—
—
0
0
43
340
1.27
0.77
1.1
1.1
—
8.82
—
0
17
168
1503
1.13
0.77
6.0
6.8
24.99
24.58
mmol/l
0.73
163
1432
12
75
1.60
0.75
3.2
1.8
—
—
—
0
0
62
515
1.21
0.73
1.2
1.1
2.22
4.76
—
5
54
5
25
2.00
0.72
1.2
1.4
—
—
—
0
0
31
237
1.31
0.72
1.7
1.8
45.81
44.54
nmol/l
0.08
31
224
36
282
1.28
0.71
1.2
1.2
3.37
5.17
u/ml
0.54
19
110
33
256
1.29
0.70
1.1
1.1
1.75
2.48
eliau/ml
0.38
12
96
5
27
1.85
0.68
1.0
1.7
138.80
107.89
%
—
5
27
9
59
1.53
0.68
1.2
1.2
—
—
—
0
0
27
352
0.76
0.68
1.3
1.4
—
—
—
0
0
432
4072
1.07
0.68
1.5
1.4
—
—
—
0
0
5
28
1.79
0.66
1.0
1.2
—
—
—
0
0
25
189
1.33
0.64
1.2
1.6
—
—
—
0
0
92
803
1.15
0.64
1.4
1.3
39.45
33.64
iu/l
0.84
86
695
13
188
0.69
0.62
1.7
1.6
—
—
—
0
0
5
30
1.67
0.61
1.2
1.1
—
—
—
0
0
40
325
1.23
0.61
1.2
1.2
270.43
270.05
u/ml
0.00
30
181
0
20
0.00
0.60
0.0
4.6
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
9.10
—
0
20
92
808
1.14
0.60
4.4
4.1
25.61
25.08
mmol/l
0.79
87
736
26
201
1.30
0.59
1.1
1.1
91.15
95.87
%
0.46
26
186
6
35
1.72
0.57
1.0
1.2
—
—
—
0
0
6
37
1.62
0.55
1.0
1.1
—
—
—
0
0
11
74
1.49
0.53
3.5
2.3
0.55
0.62
mmol/l
1.66
11
74
48
405
1.19
0.53
1.1
1.2
0.59
0.63
ratio
—
9
67
10
66
1.52
0.52
2.6
3.0
5.24
4.92
kpa
—
10
66
10
66
1.52
0.52
2.6
3.0
9.47
10.24
kpa
—
10
66
81
715
1.14
0.51
1.4
1.5
0.27
0.33
mg/l
0.52
29
286
13
180
0.72
0.51
1.5
1.4
—
—
—
0
0
29
233
1.25
0.51
1.3
1.3
338037.95
133968.06
e6/l
0.48
22
154
89
794
1.13
0.48
4.1
3.5
1.57
1.37
mmol/l
0.94
89
776
29
235
1.24
0.48
1.7
1.6
50.93
58.85
ug/l
0.49
24
196
7
47
1.49
0.47
1.0
1.3
—
—
—
0
0
27
218
1.24
0.46
1.6
1.5
—
—
—
0
0
106
961
1.11
0.45
1.3
1.4
—
—
—
0
0
27
219
1.24
0.45
1.5
1.4
—
—
—
0
0
27
220
1.23
0.43
1.6
1.5
1.00
1.11
ratio
0.41
19
142
27
220
1.23
0.43
1.6
1.5
1.37
1.21
ratio
0.41
19
142
27
220
1.23
0.43
1.6
1.5
0.98
0.96
ratio
0.15
19
142
18
139
1.30
0.43
1.3
1.4
—
—
—
0
0
18
139
1.30
0.43
1.3
1.4
—
—
—
0
0
14
185
0.76
0.43
1.0
1.0
0.16
0.16
u/ml
—
6
57
5
31
1.61
0.43
1.0
1.2
2.03
1.64
umol/24h
—
5
31
8
57
1.40
0.42
1.0
1.2
—
—
—
0
0
5
33
1.52
0.41
1.4
1.4
—
—
—
0
0
87
962
0.90
0.41
2.0
1.9
4.57
2.06
ug/l
0.31
73
841
0
15
0.00
0.41
0.0
1.0
—
0.02
—
0
10
0
15
0.00
0.41
0.0
10.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
23.01
—
0
7
0
16
0.00
0.41
0.0
1.0
—
1.95
—
0
8
36
305
1.18
0.40
1.7
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
0.03
—
0
10
51
446
1.15
0.40
1.2
1.2
1.59
1.59
g/l
0.06
51
446
47
409
1.15
0.39
5.5
4.8
295.71
316.20
iu/ml
—
7
55
5
35
1.43
0.39
1.2
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
0.02
—
0
11
96
875
1.10
0.39
1.6
1.6
14.36
16.44
u/ml
0.15
17
155
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
15
115
1.31
0.38
1.1
1.1
—
—
—
0
0
35
298
1.18
0.38
1.3
1.5
—
—
—
0
0
5
36
1.39
0.38
1.0
1.2
—
—
—
0
0
8
115
0.69
0.37
1.0
1.4
—
—
—
0
0
8
115
0.69
0.37
1.0
1.4
—
—
—
0
0
8
115
0.69
0.37
1.0
1.4
—
—
—
0
0
8
115
0.69
0.37
1.0
1.4
—
—
—
0
0
9
71
1.27
0.36
1.1
1.2
—
—
—
0
0
171
1819
0.94
0.35
2.4
2.7
58.95
63.14
ml/min/173m2
0.94
85
797
42
480
0.87
0.35
1.3
1.3
141.06
214.84
miu/ml
1.13
19
217
36
310
1.16
0.35
1.0
1.1
400.38
96.48
iu/ml
—
5
62
9
122
0.74
0.35
1.2
1.5
73.43
52.38
ug/l
—
9
122
16
126
1.27
0.35
1.0
1.1
—
—
—
0
0
10
134
0.75
0.35
2.1
2.5
—
—
—
0
0
45
395
1.14
0.35
1.9
1.9
3766.30
5434.45
u/l
0.27
20
164
16
198
0.81
0.32
1.9
1.7
4.85
4.22
mg/l
0.18
16
189
20
165
1.21
0.31
1.7
2.0
6.25
8.48
umol/l
0.50
20
113
38
333
1.14
0.31
1.1
1.1
0.63
1.26
u/ml
0.72
20
174
28
326
0.86
0.31
1.3
1.4
—
—
—
0
0
30
347
0.86
0.30
1.3
1.4
—
—
—
0
0
60
543
1.11
0.30
1.1
1.1
5.81
6.35
eliau/ml
—
7
46
28
325
0.86
0.30
1.3
1.4
—
—
—
0
0
7
55
1.27
0.30
1.0
1.0
—
—
—
0
0
45
504
0.89
0.29
1.4
1.4
257.63
1493.01
e6/l
1.29
32
386
8
106
0.75
0.29
1.0
1.3
—
—
—
0
0
16
195
0.82
0.28
1.3
1.4
—
—
—
0
0
16
195
0.82
0.28
1.3
1.4
—
—
—
0
0
16
195
0.82
0.28
1.3
1.4
—
—
—
0
0
19
227
0.84
0.28
1.3
1.2
—
—
—
0
0
30
344
0.87
0.28
1.3
1.4
—
—
—
0
0
53
479
1.11
0.28
1.7
2.6
30.18
33.06
umol/l
0.38
42
428
12
150
0.80
0.27
1.6
1.8
—
—
—
0
0
45
500
0.90
0.27
1.3
1.4
145.32
36.09
e6/l
0.34
28
361
547
5334
1.03
0.27
5.1
4.7
1.02
1.30
kg/l
0.50
387
3593
30
342
0.88
0.26
1.3
1.4
—
—
—
0
0
12
149
0.80
0.25
1.1
1.4
1.23
1.03
promille
0.17
12
115
54
592
0.91
0.25
1.2
1.5
—
—
—
0
0
53
581
0.91
0.25
1.3
1.3
614.34
544.11
mg/l
0.48
53
552
20
170
1.18
0.24
1.1
1.0
—
—
—
0
0
9
77
1.17
0.24
1.2
1.2
—
—
—
0
0
112
1185
0.94
0.23
2.1
1.8
3.54
3.50
mmol/l
0.13
84
845
29
327
0.89
0.23
1.3
1.4
—
—
—
0
0
7
91
0.77
0.22
1.0
1.5
—
—
—
0
0
7
91
0.77
0.22
1.0
1.5
—
—
—
0
0
7
92
0.76
0.22
1.0
1.5
—
—
—
0
0
5
42
1.19
0.21
1.0
1.0
31.20
42.05
iu/ml
—
5
42
0
11
0.00
0.21
0.0
1.0
—
0.01
—
0
11
0
11
0.00
0.21
0.0
1.0
—
0.01
—
0
11
0
10
0.00
0.21
0.0
1.3
—
2.90
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
20
173
1.16
0.21
1.0
1.2
—
—
—
0
0
40
364
1.10
0.20
1.8
1.8
1.63
1.65
mmol/l
0.05
40
351
0
14
0.00
0.20
0.0
1.0
—
7.66
—
0
14
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
37.36
—
0
14
0
14
0.00
0.20
0.0
1.0
—
20.71
—
0
14
31
278
1.12
0.20
1.0
1.1
1.31
2.62
u/ml
0.89
16
134
6
49
1.23
0.20
1.0
1.2
—
—
—
0
0
20
229
0.87
0.20
2.4
3.0
—
—
—
0
0
9
115
0.78
0.20
1.2
1.2
—
—
—
0
0
6
50
1.20
0.19
1.7
1.2
1.47
95.48
mg/l
—
6
37
12
99
1.21
0.19
1.2
1.6
2.07
2.05
umol/l
0.03
12
89
25
222
1.13
0.19
1.1
1.2
—
65.33
—
0
9
40
436
0.92
0.18
1.3
1.4
—
—
—
0
0
21
238
0.88
0.18
1.4
1.4
0.32
0.31
nmol/l
—
9
177
20
175
1.14
0.18
1.6
1.2
0.49
0.99
u/ml
0.34
13
94
20
227
0.88
0.18
1.2
1.5
—
—
—
0
0
12
100
1.20
0.18
1.1
1.2
—
—
—
0
0
19
216
0.88
0.17
1.3
1.2
—
—
—
0
0
5
68
0.73
0.17
1.2
1.1
—
—
—
0
0
5
68
0.73
0.17
1.2
1.1
—
—
—
0
0
23
257
0.89
0.17
1.5
1.5
—
—
—
0
0
64
603
1.06
0.16
1.4
1.5
—
—
—
0
0
48
514
0.93
0.15
1.3
1.4
—
—
—
0
0
6
76
0.79
0.15
1.0
1.0
—
—
—
0
0
123
1182
1.04
0.15
2.2
2.2
0.00
0.69
estimate
0.51
39
370
6
80
0.75
0.15
1.7
1.2
—
—
—
0
0
30
274
1.10
0.15
1.1
1.1
—
—
—
0
0
91
869
1.05
0.15
1.3
1.4
—
—
—
0
0
16
140
1.14
0.15
1.3
1.5
—
—
—
0
0
16
140
1.14
0.15
1.5
1.9
—
—
—
0
0
9
82
1.10
0.15
2.0
2.4
19.97
112.08
ug/l
—
9
74
22
244
0.90
0.14
1.2
1.5
—
—
—
0
0
59
622
0.95
0.13
1.3
1.5
—
—
—
0
0
15
169
0.89
0.12
1.3
1.2
—
—
—
0
0
688
6803
1.02
0.12
4.7
4.5
0.00
0.00
estimate
1.47
281
2378
12
137
0.88
0.12
1.2
1.1
—
—
—
0
0
62
591
1.05
0.11
3.3
4.1
20.52
30.73
u/ml
1.58
62
574
11
126
0.87
0.11
1.1
1.2
134.35
136.27
nmol/l
0.06
11
126
12
105
1.14
0.11
1.3
1.6
—
—
—
0
0
10
115
0.87
0.10
3.8
4.3
—
—
—
0
0
29
271
1.07
0.09
1.0
1.1
1.27
1.33
u/ml
0.02
14
111
23
247
0.93
0.08
1.0
1.0
0.46
0.74
u/ml
0.53
15
120
15
136
1.10
0.08
1.4
1.9
—
—
—
0
0
12
107
1.12
0.08
1.2
1.2
—
—
—
0
0
21
195
1.08
0.08
1.0
1.1
—
—
—
0
0
7
67
1.04
0.08
1.0
1.1
—
—
—
0
0
6
70
0.86
0.07
1.0
1.1
—
—
—
0
0
11
98
1.12
0.07
1.0
1.3
—
—
—
0
0
37
353
1.05
0.07
1.4
1.3
—
—
—
0
0
46
442
1.04
0.07
1.3
1.4
—
—
—
0
0
9
102
0.88
0.06
1.0
1.6
26.00
31.39
umol/l
—
9
96
31
296
1.05
0.05
1.4
1.5
—
—
—
0
0
51
496
1.03
0.04
4.7
3.8
25.25
25.97
mg/l
0.05
37
353
28
269
1.04
0.04
1.0
1.1
—
—
—
0
0
60
588
1.02
0.03
1.2
1.2
—
10.84
—
0
5
18
171
1.05
0.03
1.4
1.3
2.52
2.15
mmol/l
0.61
18
160
44
429
1.03
0.03
1.1
1.2
1320.00
270.27
titre
—
5
37
16
152
1.05
0.02
1.3
1.5
—
—
—
0
0
18
188
0.96
0.02
1.3
1.2
—
—
—
0
0
68
671
1.01
0.01
1.4
1.7
6.35
4.56
mg/l
0.41
53
513
15
143
1.05
0.01
1.3
1.2
—
—
—
0
0
161
1620
0.99
0.01
2.3
2.0
3.53
3.31
ratio
1.46
131
1284
18
173
1.04
0.01
1.3
1.2
—
—
—
0
0
41
417
0.98
0.01
1.3
1.6
—
—
—
0
0
13
124
1.05
0.00
1.1
1.2
—
—
—
0
0
14
134
1.05
0.00
1.4
1.5
—
—
—
0
0
23
224
1.03
0.00
1.0
1.1
—
5.37
—
0
6
10
95
1.05
0.00
1.1
1.1
1253.70
1634.74
miu/ml
—
10
95
11
115
0.96
0.00
1.2
1.6
39.10
39.77
g/l
0.19
11
115
15
145
1.03
0.00
1.3
1.2
—
—
—
0
0
18
175
1.03
0.00
1.3
1.2
—
—
—
0
0
18
175
1.03
0.00
1.3
1.2
—
—
—
0
0
12
119
1.01
0.00
1.5
2.1
0.59
0.65
e9/l
0.17
12
114
30
299
1.00
0.00
5.9
5.3
352.08
355.17
umol/l
0.05
25
265
32
316
1.01
0.00
1.4
2.3
15.55
24.60
mg/l
1.11
11
112
11
108
1.02
0.00
6.4
3.0
0.59
1.34
%
1.71
11
108
11
112
0.98
0.00
1.4
1.2
0.64
0.51
ratio
—
5
71
12
122
0.98
0.00
1.2
1.1
1.03
1.18
u/l
—
6
66
28
282
0.99
0.00
1.6
1.9
88.88
89.54
%
0.23
28
275
32
318
1.01
0.00
1.2
1.1
—
0.91
—
0
6
66
658
1.00
0.00
4.6
3.7
3.86
3.83
mmol/l
0.18
66
651
56
557
1.01
0.00
3.9
3.1
7.98
7.61
mmol/l
0.51
56
544
10
103
0.97
0.00
1.0
1.2
159.80
330.81
u/l
—
10
91
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.1
—
—
—
0
0
5
56
0.89
-0.00
2.0
2.7
12.60
5.55
ug/l
—
5
56
8
85
0.94
-0.00
1.1
1.1
—
12.27
—
0
11
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
76.83
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
-0.00
1.1
1.1
—
—
—
0
0
6
62
0.97
-0.00
1.0
1.1
—
—
—
0
0
6
62
0.97
-0.00
2.0
1.6
7.13
9.30
ug/l
—
6
62
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1.98
—
0
6
8
79
1.01
-0.00
1.1
1.2
12.88
10.18
mm/h
—
8
79
6
59
1.02
-0.00
1.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXGOITMULT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITMULT | 1.258 [1.14, 1.39] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.248 |
During the follow-up period (1.1.1998 — 31.12.2019), 1886 out of 8353 females with E4_THYTOXGOITMULT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITMULT | 1.226 [1.04, 1.45] | 0.016 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 410 out of 1483 males with E4_THYTOXGOITMULT died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXGOITMULT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.142% | 0.251% |
| 5 | 0.77% | 1.437% |
| 10 | 1.909% | 3.544% |
| 15 | 3.56% | 6.687% |
| 20 | 6.338% | 11.5% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXGOITMULT – Thyrotoxicosis with toxic multinodular goitre
GWS hits: 26
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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