Toxic Nodular Goiter: Nodular enlargement of the thyroid gland associated with hyperthyroidism.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2195 |
4. Check minimum number of eventsNone |
2195 |
5. Include endpointsNone |
2195 |
6. Filter based on genotype QC (FinnGen only) |
2195 |
Control definitions (FinnGen only)
- Control exclude
- THYROTOXICOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis cum struma multinodulari
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis with toxic multinodular goitre
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18329 | 15393 | 2783 |
| Only index persons | 14535 | 12435 | 2100 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.38 | 0.44 | 0.08 |
| Only index persons | 0.40 | 0.46 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 60.94 | 60.51 | 63.51 |
| Only index persons | 60.38 | 59.55 | 65.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2195 | 1782 | 413 |
| Unadjusted period prevalence (%) | 0.53 | 0.61 | 0.18 |
| Median age at first event (years) | 60.77 | 59.30 | 67.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1944
- Matched controls
- 19439
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
14100.9
323.0
1600
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
743.3
323.0
580
11
H03BB01
ATC
carbimazole; oral
815.3
323.0
1174
36
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
323.0
472
*
BAA60
NOMESCO Finland
Total thyroidectomy
37.7
323.0
453
155
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
+∞
316.5
295
*
H03AA01
ATC
levothyroxine sodium; systemic
6.0
286.1
1124
3592
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
37.0
247.2
320
103
104
Kela drug reimbursment
Thyroid insufficiency
8.0
221.6
566
949
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
736.1
205.4
199
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
9.7
159.6
346
423
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
162.4
143.6
150
10
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
55.9
142.3
169
33
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
212.0
134.6
138
7
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
21.3
122.3
184
95
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
9.5
85.2
183
211
T85
ICPC
Hyperthyroidism/thyrotoxicosis
51.1
73.1
88
18
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.7
64.1
233
542
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
63.9
61
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
60.7
58
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
10.4
60.6
122
124
2422A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic multinodular goitre
+∞
55.5
53
*
C07AA05
ATC
propranolol; systemic
2.5
49.0
483
2309
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
45.3
43.3
53
12
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
54.6
40.6
48
9
C07AB07
ATC
bisoprolol; oral
1.9
39.8
1058
7521
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
32.7
347
1682
E05.89
ICD-10 Finland
Other thyrotoxicosis
322.1
31.9
32
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
5.0
31.3
104
218
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
10.0
31.2
63
65
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
44.5
28.7
35
8
A11CC03
ATC
alfacalcidol; systemic
5.5
28.6
87
165
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
9.5
28.5
59
64
T86
ICPC
Hypothyroidism/myxoedema
3.5
28.3
139
419
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
27.6
830
5874
E03.89
ICD-10 Finland
Other specified hypothyroidism
3.7
27.2
122
341
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.3
23.3
72
140
H062, E050
ICD-10 Finland
NA
+∞
23.0
22
*
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
232.6
22.7
23
*
24209
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffuse NUD
+∞
21.9
21
*
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
16.2
21.9
35
22
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.8
21.5
93
253
106
Kela drug reimbursment
Hypoparathyroidism
17.6
21.3
33
19
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
4.8
20.1
67
142
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
19.4
477
3108
E03
ICD-10 Finland
Other hypothyroidism
2.4
18.8
168
739
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
14.3
18.6
31
22
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
17.4
416
2675
T81
ICPC
Goitre
11.2
17.2
32
29
E83.51
ICD-10 Finland
Hypocalcemia
13.4
17.0
29
22
24200
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffusa et exophthalmo. Morbus Basedowi
+∞
16.7
16
*
H03BA02
ATC
propylthiouracil; oral
+∞
16.7
16
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
4.8
16.5
55
118
WX402
NOMESCO Finland
General anaesthesia
1.8
16.4
316
1898
B01AA03
ATC
warfarin; systemic
1.7
15.4
406
2671
E04.8
ICD-10 Finland
Other specified nontoxic goitre
12.0
14.6
26
22
N02BE01
ATC
paracetamol; systemic, rectal
1.6
14.3
1660
15167
ZXA10
NOMESCO Finland
Bilateral
1.6
14.3
404
2702
207
Kela drug reimbursment
Chronic arrhythmias
1.7
14.2
308
1912
A11CC02
ATC
dihydrotachysterol; oral
22.4
14.2
20
9
TFP20
NOMESCO Finland
Cardiodefibrillation
2.2
13.7
144
685
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
13.7
487
3450
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
13.4
299
1873
GB1AA
NOMESCO Finland
Tracheal X-ray examination
21.3
13.3
19
9
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
21.3
13.3
19
9
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.8
13.2
265
1607
I50.9
ICD-10 Finland
Heart failure, unspecified
1.7
12.9
280
1737
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
7.9
12.6
28
36
24400
ICD-8 Finland
Myxoedema, (hypothyreosis) post therapiam
32.2
12.6
16
5
C03CA01
ATC
furosemide; systemic
1.5
12.3
598
4518
R06.0
ICD-10 Finland
Dyspnoea
1.5
12.2
481
3475
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.0
12.0
167
892
C07AA07
ATC
sotalol; systemic
2.5
12.0
94
388
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
12.0
326
2151
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
6.5
11.9
30
47
L28
ICPC
Limited function/disability (L)
1.6
11.8
324
2144
E05.5
ICD-10 Finland
Thyroid crisis or storm
+∞
11.5
11
*
R4110
NOMESCO Finland
Physiotherapy
1.5
10.8
493
3656
H05.2
ICD-10 Finland
Exophthalmic conditions
15.6
10.8
17
11
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
10.8
1146
9900
24220
ICD-8 Finland
Thyrotoxicosis with or without goitre, Thyrotoxicosis without mention of goitre
+∞
10.4
10
*
A12AA04
ATC
calcium carbonate; oral
4.1
10.3
39
97
C07AB02
ATC
metoprolol; systemic
1.5
10.1
420
3051
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
9.5
359
2552
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
9.4
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
9.0
789
6529
R53
ICD-10 Finland
Malaise and fatigue
1.5
9.0
381
2771
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
18.7
8.9
13
7
E04
ICD-10 Finland
Other nontoxic goitre
7.5
8.9
20
27
ZXA05
NOMESCO Finland
Left side
1.4
8.8
487
3726
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.8
8.8
150
863
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
8.6
8.8
18
21
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.3
8.7
78
346
Z01.7
ICD-10 Finland
Laboratory examination
1.6
8.5
197
1246
R03BB04
ATC
tiotropium bromide; inhalant
1.7
8.4
176
1079
J01DA01
ATC
[U] cefalexin; systemic
1.3
8.2
1117
9827
R00.2
ICD-10 Finland
Palpitations
1.8
8.1
127
711
C01AA05
ATC
digoxin; systemic
1.7
7.5
162
999
K78
ICPC
Atrial fibrillation/flutter
1.7
7.5
147
886
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
3.3
7.5
35
107
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.5
7.4
287
2044
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
6.5
7.4
18
28
C03DA01
ATC
spironolactone; oral
1.6
7.4
198
1299
Z01.8
ICD-10 Finland
Other specified special examinations
1.4
7.3
369
2765
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
7.3
834
7112
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.4
7.3
57
237
B01AB05
ATC
enoxaparin; parenteral
1.3
7.2
565
4556
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
7.2
527
4213
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
30.1
7.1
9
*
J01DB01
ATC
cefalexin; oral
1.3
7.1
1448
13346
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.4
7.0
404
3103
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
7.5
6.9
15
20
TPH07
NOMESCO Finland
Cathetrisation of artery
1.6
6.9
173
1114
Z71.8
ICD-10 Finland
Other specified counselling
1.4
6.8
378
2879
A02BC02
ATC
pantoprazole; systemic
1.3
6.7
1198
10788
XF400
NOMESCO Finland
ECG with 12 standard connections
1.4
6.7
276
1991
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
6.6
270
1942
R03AC02
ATC
salbutamol; inhalant
1.3
6.6
904
7858
E20.9
ICD-10 Finland
Hypoparathyroidism, unspecified
12.3
6.6
11
9
WZC30
NOMESCO Finland
Teaching
1.5
6.5
214
1472
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.4
6.5
369
2823
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.6
6.5
166
1078
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.0
6.5
81
419
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
6.5
475
3787
J01AA02
ATC
doxycycline; systemic
1.3
6.5
1428
13192
A27
ICPC
Fear of other disease NOS
1.9
6.4
87
468
2504
FHL
Unilateral resection or enucleation
3.5
6.3
27
78
E05.3
ICD-10 Finland
Thyrotoxicosis from ectopic thyroid tissue
+∞
6.3
6
*
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
+∞
6.3
6
*
WX892
NOMESCO Finland
Monitored bed care
1.7
6.2
120
718
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
6.1
236
1682
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
6.0
501
4058
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
2.8
6.0
36
131
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1118
947
23.02
307.65
5.4
2.4
4.82
4.32
pmol/l
25.61
1035
809
892
255
58.24
307.65
1.8
1.2
24.91
2.83
iu/l
0.84
299
48
500
1114
5.52
218.70
1.3
1.2
98.90
133.19
iu/ml
0.81
150
399
1990
14579
4.91
119.48
12.2
4.1
15.75
14.92
pmol/l
36.93
1913
13100
1482
9988
2.49
85.40
7.7
6.3
1.21
1.22
mmol/l
3.32
1271
8360
210
507
4.47
80.04
1.2
1.2
—
—
—
0
0
428
1661
2.96
79.10
3.3
3.4
67.90
87.22
ng/l
5.72
378
1376
1337
9055
2.22
69.48
6.7
5.6
1.21
1.22
mmol/l
4.04
1255
8085
2019
17101
3.25
53.17
13.6
5.0
1.50
2.14
mu/l
5.95
1940
15439
1444
10753
2.00
50.04
8.7
8.8
4.01
4.05
e9/l
0.26
1236
9333
51
60
8.68
40.06
1.6
1.5
15.69
14.85
pmol/l
0.61
46
48
1145
8393
1.76
36.25
2.6
2.3
77.96
80.12
nmol/l
1.88
1041
7400
78
165
4.86
34.73
4.3
4.7
119.99
59.74
u/ml
0.30
16
49
1657
13967
1.76
27.72
4.4
4.3
13.73
13.68
mm/h
0.05
1567
12788
687
4716
1.66
25.02
4.2
3.7
88.74
90.97
%
1.38
674
4586
1056
8082
1.59
24.49
10.4
9.6
0.00
0.00
e9/l
1.43
840
6539
1689
14638
1.67
21.82
8.2
7.4
78.50
79.03
u/l
0.25
1623
13635
1340
10999
1.56
21.75
5.2
4.4
6.73
6.71
mmol/l
0.14
1280
10287
775
5648
1.58
21.33
3.8
3.2
98.83
69.83
e6/l
0.21
584
4285
930
7072
1.55
21.13
3.5
3.4
2.35
2.36
mmol/l
2.00
825
6069
1087
8554
1.54
21.10
5.8
5.8
2.80
2.81
%
0.04
1005
7887
1109
8777
1.53
20.89
5.8
5.9
26.75
27.63
%
1.95
1026
8076
1178
9460
1.53
20.63
5.7
5.8
0.19
0.19
e9/l
0.38
1025
8165
390
2412
1.75
20.35
5.1
5.0
1.05
1.04
mmol/l
0.27
355
2203
1090
8658
1.51
19.76
5.6
5.7
58.39
57.49
%
1.75
1013
8000
878
6669
1.53
19.62
4.4
3.7
108.47
116.66
e6/l
0.11
622
4629
1675
14668
1.60
18.79
25.1
18.4
13.83
13.80
%
0.39
1643
14317
714
5226
1.54
18.72
3.7
3.1
0.35
0.53
e6/l
1.88
525
3911
460
3059
1.64
18.08
3.1
3.1
0.79
0.81
mmol/l
5.15
429
2820
637
4613
1.54
17.25
2.3
2.3
—
—
—
0
0
1082
8737
1.47
17.13
4.0
4.0
—
—
—
0
0
445
2972
1.62
17.09
3.1
2.9
3.44
3.39
e6/l
0.04
238
1566
532
3776
1.54
15.54
4.2
3.8
434.14
275.22
ng/l
0.26
438
3031
1051
8542
1.44
15.48
4.7
4.4
34.88
35.16
g/l
0.95
979
7886
460
3181
1.56
15.04
1.8
1.8
—
—
—
0
0
378
2508
1.61
14.71
2.5
2.4
21.08
21.92
%
0.47
322
2114
1014
8301
1.41
13.75
2.2
2.1
94.07
95.73
pmol/l
0.49
524
3991
1952
18112
1.70
13.58
19.1
15.0
22.76
23.43
mg/l
0.40
1680
14456
321
2093
1.63
13.33
2.5
2.6
7.26
7.74
umol/l
0.20
279
1793
393
2696
1.56
13.15
2.5
2.4
2.32
2.33
g/l
0.07
359
2481
451
3191
1.52
13.09
3.0
2.7
1.08
1.46
e6/l
1.16
243
1775
335
2224
1.60
12.89
1.8
1.7
—
—
—
0
0
421
2944
1.53
12.89
2.6
2.4
12.24
12.59
umol/l
0.26
393
2715
334
2219
1.60
12.81
1.8
1.7
—
—
—
0
0
1860
17106
1.57
12.80
18.7
14.2
76.51
76.19
ml/min/173m2
0.25
1610
14083
766
6030
1.42
12.71
3.4
3.0
1524.88
1426.44
ng/l
0.29
677
5177
538
3972
1.47
12.62
3.1
2.5
6.11
6.77
e6/l
0.58
460
3442
270
1718
1.65
12.32
2.1
2.1
354.57
372.24
nmol/l
0.78
252
1551
269
1722
1.64
11.97
2.2
2.3
31.39
37.31
u/l
1.32
227
1463
272
1747
1.64
11.94
3.2
2.9
259.55
212.22
ng/l
0.72
240
1601
402
2826
1.52
11.93
2.1
2.0
30.39
29.64
s
1.39
390
2728
267
1715
1.63
11.71
4.0
3.6
1.22
1.23
mmol/l
1.10
238
1478
2010
18937
1.73
11.43
22.8
17.5
139.79
139.64
mmol/l
1.84
1981
18425
371
2588
1.52
11.37
31.5
25.4
1.45
1.33
inr
0.73
57
347
170
973
1.81
11.33
6.8
7.7
25.28
24.55
mmol/l
2.11
165
906
1445
12778
1.38
11.26
6.0
5.1
1885.32
2680.54
e6/l
0.21
22
179
938
7751
1.37
11.23
3.3
2.8
116.66
119.65
ug/l
0.15
863
7080
2011
18981
1.71
10.94
23.1
17.6
3.94
3.96
mmol/l
3.61
1979
18437
525
3974
1.42
10.50
3.2
3.0
2.46
2.47
mmol/l
0.19
446
3494
1163
10010
1.34
10.36
5.7
6.0
10.81
11.07
umol/l
0.48
1122
9444
1829
16940
1.48
10.32
6.9
6.1
40.51
40.07
mmol/mol
1.22
1696
15453
334
2331
1.51
10.15
6.2
5.9
103.91
104.12
mmol/l
0.31
324
2284
89
424
2.15
10.09
1.2
1.3
—
—
—
0
0
89
424
2.15
10.09
1.2
1.3
—
—
—
0
0
62
253
2.49
10.05
1.7
1.4
33.37
32.37
g/l
0.27
57
228
2021
19163
1.69
9.99
13.0
10.9
23.35
23.95
u/l
1.02
1981
18359
147
844
1.79
9.71
3.5
3.4
24.93
24.21
mmol/l
1.34
140
759
1899
17794
1.50
9.38
5.2
4.9
6.05
5.95
mmol/l
2.68
1736
15974
113
605
1.91
9.31
1.6
2.3
0.03
0.02
g/l
0.11
99
554
276
1882
1.53
9.31
6.2
6.8
94.49
95.56
%
1.17
270
1817
106
557
1.95
9.24
1.5
2.3
0.01
0.00
g/l
0.49
93
509
308
2156
1.50
9.18
6.1
6.4
11.82
12.30
kpa
0.92
300
2054
308
2156
1.50
9.18
6.1
6.4
5.31
5.10
kpa
2.34
302
2054
307
2149
1.50
9.15
6.1
6.4
1.76
1.28
mmol/l
1.42
261
1692
620
4922
1.36
9.13
2.4
2.3
3.09
3.10
mg/l
0.06
535
4171
123
691
1.83
8.75
1.6
2.4
0.36
0.88
g/l
2.08
102
593
256
1741
1.53
8.73
6.7
7.1
120.63
118.89
g/l
0.69
249
1684
103
550
1.92
8.58
1.5
2.3
0.00
0.00
g/l
0.00
93
508
190
1219
1.61
8.35
1.8
1.7
—
—
—
0
0
1925
18173
1.48
8.28
5.5
5.2
2.67
2.75
mmol/l
2.96
1782
16433
298
2115
1.47
8.26
4.0
3.9
235.98
248.02
u/l
0.80
273
1983
114
638
1.83
8.22
1.5
2.2
36.52
37.49
g/l
1.25
93
535
37
131
2.86
7.96
1.5
1.2
11.57
10.46
u/l
0.34
37
115
440
3374
1.38
7.91
1.4
1.4
2.27
2.42
g/l
0.78
240
1921
112
632
1.81
7.88
1.6
3.3
131.58
51.06
mg/l
0.37
98
518
111
631
1.80
7.63
1.7
3.3
46.23
159.22
mg/l
0.68
97
517
42
164
2.59
7.53
1.5
1.3
412.79
295.64
u/l
0.36
42
157
2059
19790
1.65
7.45
30.0
22.4
4.44
4.38
e12/l
7.48
2011
19161
2059
19793
1.65
7.41
30.1
22.4
6.78
6.67
e9/l
1.17
2014
19159
2059
19794
1.65
7.39
30.2
22.5
132.82
131.84
g/l
2.60
2041
19463
34
120
2.86
7.38
1.6
1.5
11.68
13.60
u/l
1.07
34
111
2058
19784
1.64
7.36
30.0
22.4
255.65
254.83
e9/l
0.23
2019
19222
78
400
1.99
7.35
1.5
1.4
—
—
—
0
0
237
1644
1.50
7.35
2.2
2.6
64.06
66.37
g/l
4.72
208
1473
108
618
1.79
7.27
1.6
3.2
1.91
1.66
ratio
—
9
54
126
754
1.71
7.26
1.7
2.4
3.31
3.13
g/l
1.08
96
581
245
1719
1.48
7.18
3.9
3.3
2.49
2.04
mmol/l
0.94
213
1416
1710
15923
1.33
7.11
23.1
16.4
38.83
38.44
%
0.90
1238
10532
53
237
2.27
7.11
1.8
1.4
1652.19
1618.14
e6/l
0.03
37
170
231
1606
1.49
7.08
6.0
5.7
1.16
1.32
mmol/l
2.65
226
1545
228
1585
1.49
6.99
7.3
6.6
10.94
9.95
mmol/l
0.98
213
1514
90
495
1.85
6.91
3.3
3.3
0.83
0.81
nmol/l
0.13
73
387
48
209
2.33
6.85
1.8
1.3
24823.59
87748.82
e6/l
0.92
27
115
244
1732
1.46
6.74
3.9
3.3
5.97
5.81
kpa
1.36
238
1685
207
1422
1.50
6.73
1.6
1.6
—
—
—
0
0
1117
9901
1.26
6.61
2.9
2.7
—
—
—
0
0
587
4808
1.30
6.61
1.7
1.6
19.78
21.31
nmol/l
1.72
514
4015
33
122
2.73
6.61
1.2
1.1
284.00
111.50
titre
—
5
20
121
744
1.66
6.34
1.6
2.3
9.66
10.22
g/l
0.77
98
624
683
5731
1.28
6.33
3.3
3.1
29.97
35.49
u/l
1.47
647
5421
490
3939
1.31
6.30
1.3
1.3
1.42
1.46
u/ml
0.04
108
1004
1799
16958
1.34
6.28
4.2
4.1
1.28
1.28
mmol/l
0.01
1638
15156
128
803
1.63
6.20
1.7
2.3
3.72
3.69
g/l
0.08
96
564
128
804
1.63
6.18
1.7
2.3
—
—
—
0
0
128
804
1.63
6.18
1.7
2.3
7.68
7.50
g/l
0.43
97
592
709
5993
1.27
6.15
4.0
3.8
10.46
8.54
mg/mmol
0.39
430
3522
1869
17740
1.36
6.06
4.8
4.6
4.60
4.72
mmol/l
5.85
1736
16117
31
117
2.67
5.99
1.2
1.2
33.96
16.73
u/l
0.60
26
100
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
102
610
1.70
5.94
2.4
2.7
0.37
0.38
u/ml
0.11
60
356
692
5855
1.27
5.91
3.2
3.0
6.49
6.62
mmol/l
0.35
553
4829
568
4691
1.28
5.91
2.9
2.6
4750.29
6075.57
umol/l
0.28
473
3975
272
2017
1.40
5.90
3.5
3.4
—
—
—
0
0
506
4121
1.30
5.86
1.9
1.7
1.35
1.25
mg/l
0.36
398
3188
706
5994
1.26
5.84
2.5
2.4
56.82
57.78
u/l
0.26
664
5476
46
212
2.19
5.80
1.2
1.2
71.81
53.65
u/l
0.95
36
142
671
5670
1.26
5.77
3.3
3.1
353.50
346.95
mg/l
0.01
421
3339
850
7390
1.25
5.67
4.2
3.8
112.36
101.16
ng/l
0.04
599
5288
1852
17593
1.34
5.66
4.7
4.6
1.49
1.55
mmol/l
6.16
1697
15882
287
2180
1.36
5.37
2.5
2.5
1.86
1.84
%
0.14
254
1909
67
371
1.83
5.12
1.6
1.6
252.23
314.96
mu/l
1.63
62
333
167
1166
1.47
5.05
7.9
7.4
92.81
93.78
%
0.71
167
1160
185
2542
0.70
4.99
8.3
7.2
—
—
—
0
0
1223
11142
1.22
4.98
3.3
3.1
44.26
48.00
u/l
0.90
1152
10155
61
331
1.87
4.97
1.2
1.2
—
—
—
0
0
1029
9225
1.22
4.89
5.9
5.5
0.00
0.00
estimate
0.50
194
1659
1021
9162
1.21
4.76
4.2
4.1
0.00
0.00
estimate
0.00
189
1666
47
237
2.00
4.76
1.3
1.4
337.26
291.48
pmol/l
0.27
34
182
164
1160
1.45
4.65
8.0
7.4
0.64
0.68
%
0.69
164
1151
593
5054
1.24
4.55
1.7
1.6
1.37
1.34
mmol/l
0.31
483
4219
84
518
1.65
4.44
1.8
1.6
—
—
—
0
0
19
65
2.94
4.44
1.4
1.5
0.33
0.46
ug/l
0.60
12
37
1034
9330
1.20
4.44
4.3
4.1
0.01
0.01
estimate
0.00
183
1660
128
871
1.50
4.43
1.5
1.7
1.70
1.58
g/l
0.85
108
746
13
36
3.63
4.20
2.5
1.4
114.23
88.22
ng/l
0.34
13
36
37
182
2.05
4.05
1.3
1.2
—
—
—
0
0
276
2224
1.28
3.40
3.0
3.9
4.47
18.07
ug/l
2.77
223
1802
671
5957
1.18
3.19
2.1
2.1
178.65
207.76
u/l
0.41
631
5538
25
117
2.15
3.16
1.6
1.6
—
—
—
0
0
189
1469
1.31
3.08
3.6
3.1
0.65
0.79
ug/l
2.31
142
1008
105
745
1.43
3.03
1.9
1.8
—
—
—
0
0
77
516
1.51
2.96
1.5
1.7
—
—
—
0
0
456
3939
1.20
2.93
1.8
1.8
1121.42
1186.99
nmol/l
0.76
364
2895
42
244
1.74
2.87
1.1
1.2
16.94
14.55
u/l
0.38
35
190
104
745
1.42
2.86
2.9
3.1
286.55
2121.79
u/ml
0.74
86
627
14
54
2.60
2.70
1.1
1.2
120.21
115.36
%
0.43
14
45
87
612
1.44
2.66
2.6
2.8
—
—
—
0
0
205
1648
1.27
2.61
2.4
2.5
72.56
70.41
e9/l
0.38
153
1258
79
548
1.46
2.61
1.4
1.6
1.14
1.18
g/l
0.57
73
520
9
26
3.47
2.48
1.4
1.5
—
—
—
0
0
109
809
1.37
2.47
2.0
1.9
—
—
—
0
0
145
1125
1.31
2.45
1.6
1.5
—
—
—
0
0
76
531
1.45
2.44
1.3
1.6
0.23
0.24
g/l
0.23
70
505
7
17
4.13
2.36
10.1
15.9
4.99
5.65
mmol/l
—
7
17
13
52
2.51
2.36
1.2
1.3
28.08
515.69
ug/l
—
5
32
59
396
1.50
2.32
2.0
2.0
132.03
126.74
g/l
0.86
38
281
58
389
1.50
2.29
1.7
1.6
—
—
—
0
0
36
580
0.61
2.25
1.4
1.4
—
—
—
0
0
59
399
1.49
2.25
1.2
1.6
—
—
—
0
0
208
2514
0.81
2.23
4.7
4.7
33.11
33.56
%
0.24
155
1585
224
1857
1.23
2.21
2.1
2.1
0.21
0.21
g/l
0.22
209
1734
39
242
1.62
2.16
1.6
1.5
44.92
59.21
%
1.13
26
154
71
506
1.42
2.09
2.0
2.1
10.26
11.15
nmol/l
0.35
61
432
9
31
2.91
2.07
1.1
1.3
—
—
—
0
0
67
476
1.42
2.01
1.9
1.7
12942.96
13778.22
e6/l
0.07
49
348
82
605
1.37
1.99
1.2
1.3
—
—
—
0
0
482
4317
1.15
1.95
1.8
1.7
57357036.25
24463346.42
pmol/l
0.47
401
3491
5
11
4.55
1.94
1.2
1.0
—
—
—
0
0
7
22
3.19
1.88
1.0
1.8
—
—
—
0
0
7
22
3.19
1.88
2.6
2.8
1.29
0.68
u/field
—
7
22
70
511
1.38
1.83
1.5
1.3
—
—
—
0
0
299
2596
1.18
1.83
1.5
1.4
—
—
—
0
0
22
123
1.80
1.80
1.0
1.0
298.95
294.44
mg/l
0.12
22
102
123
978
1.27
1.79
1.7
1.8
—
—
—
0
0
6
18
3.34
1.74
2.3
1.2
—
—
—
0
0
85
646
1.33
1.74
2.2
2.2
304.03
782.29
ug/l
0.83
74
603
129
1038
1.26
1.71
1.5
1.7
1.27
1.47
g/l
0.68
121
935
22
126
1.75
1.68
1.2
1.2
—
—
titre
—
0
0
55
392
1.41
1.67
1.2
1.2
—
—
—
0
0
182
1531
1.21
1.61
1.7
1.7
1.48
1.45
%
0.26
151
1307
238
2054
1.18
1.58
4.6
4.5
20.44
21.43
%
0.52
117
1037
16
85
1.89
1.55
1.1
1.1
—
—
—
0
0
59
433
1.37
1.54
2.4
3.1
1.81
1.60
mg/l
0.96
53
398
18
100
1.81
1.53
2.1
1.8
1.50
2.79
u/field
0.66
12
71
108
868
1.26
1.48
1.6
1.7
—
—
—
0
0
24
147
1.64
1.47
1.7
2.0
—
—
—
0
0
22
132
1.67
1.46
1.8
1.6
4.00
6.43
u/l
0.57
14
58
200
1717
1.18
1.44
2.5
2.4
5.27
6.28
ug/l
0.44
176
1452
111
900
1.25
1.42
1.0
1.0
—
—
—
0
0
132
1091
1.22
1.42
1.2
1.3
79.33
44.87
au/ml
—
6
50
290
2573
1.15
1.37
5.7
5.3
3.83
3.41
ug/l
0.15
246
2246
43
306
1.41
1.36
5.0
3.5
1.05
1.34
%
0.36
32
238
57
426
1.35
1.36
1.4
1.3
—
—
—
0
0
240
2102
1.16
1.35
1.9
2.0
155.14
136.49
ug/g
0.29
196
1604
13
68
1.92
1.33
1.1
3.1
57.67
181.81
umol/l
—
6
43
53
396
1.35
1.28
2.5
2.7
8.16
8.04
kpa
0.26
47
362
15
84
1.79
1.27
1.2
1.9
0.24
0.20
e9/l
—
10
73
8
35
2.29
1.27
1.4
1.2
—
—
—
0
0
75
591
1.28
1.25
1.3
1.4
296.02
286.42
ug/g
0.14
41
335
741
6973
1.09
1.22
4.5
4.4
—
—
—
0
0
48
356
1.36
1.22
1.6
2.7
30.48
34.71
umol/l
0.47
32
298
5
19
2.64
1.21
1.2
1.4
—
—
—
0
0
143
1216
1.19
1.18
2.3
2.4
20.08
27.45
au/ml
—
6
53
0
34
0.00
1.16
0.0
1.1
—
—
—
0
0
19
118
1.62
1.15
1.4
1.3
—
—
—
0
0
19
119
1.60
1.11
1.4
1.3
—
—
—
0
0
152
1308
1.17
1.11
2.3
2.7
9.75
10.45
g/l
1.35
138
1182
138
1181
1.18
1.08
6.7
6.6
25.11
24.58
mmol/l
1.16
131
1101
15
89
1.69
1.07
1.4
1.3
—
—
—
0
0
15
89
1.69
1.07
1.4
1.3
—
—
—
0
0
27
186
1.46
1.06
1.5
1.4
—
—
—
0
0
20
129
1.56
1.05
1.1
1.2
—
—
—
0
0
93
770
1.22
1.04
1.6
1.9
35.99
39.31
u/l
0.94
83
676
24
162
1.49
1.04
1.0
1.1
—
—
—
0
0
71
572
1.25
1.03
1.3
1.3
40.87
33.58
iu/l
0.91
65
487
26
179
1.46
1.03
1.7
1.4
28.00
33.26
%
0.25
17
112
69
556
1.25
1.00
1.2
1.2
—
—
—
0
0
15
91
1.65
1.00
1.7
1.3
6.67
5.33
%
—
6
18
134
1156
1.17
0.97
4.0
3.7
5.33
5.20
kpa
0.75
125
1062
9
50
1.80
0.96
1.1
1.1
—
—
—
0
0
53
416
1.28
0.96
2.1
2.3
47.27
101.57
ug/min
1.41
31
238
68
551
1.24
0.95
1.2
1.2
—
—
—
0
0
33
243
1.36
0.93
1.4
1.4
104.83
110.54
u/ml
—
6
49
6
28
2.15
0.91
1.5
1.2
28.33
1444.47
u/l
—
6
17
151
1323
1.15
0.91
3.0
3.6
115.53
60.79
u/ml
0.28
146
1275
39
296
1.32
0.91
5.8
4.8
336.50
325.64
iu/ml
—
6
39
8
42
1.91
0.88
1.1
1.1
—
—
—
0
0
63
512
1.24
0.88
1.1
1.2
—
34.00
—
0
36
126
1093
1.16
0.88
1.3
1.2
154.50
184.36
u/ml
0.27
116
995
32
238
1.35
0.86
1.0
1.1
—
—
—
0
0
105
901
1.17
0.84
2.8
2.4
1.16
1.12
%
0.24
105
895
52
416
1.26
0.84
1.2
1.1
—
—
—
0
0
60
489
1.23
0.82
1.4
1.5
—
—
—
0
0
126
1100
1.15
0.82
4.0
3.7
2.71
2.01
mmol/l
1.10
104
828
25
180
1.39
0.82
2.0
2.3
3.08
2.13
u/field
0.41
13
61
14
89
1.58
0.81
1.4
1.4
6.05
5.98
mmol/l
0.04
14
84
14
89
1.58
0.81
1.2
1.9
518.11
451.99
e6/l
—
9
74
24
172
1.40
0.81
1.4
1.6
45.46
43.75
nmol/l
0.10
24
162
28
207
1.36
0.79
1.3
1.3
278.74
275.74
mosm/kgh2o
0.34
23
152
32
243
1.32
0.77
1.2
1.2
294.13
267.45
u/ml
0.25
23
147
335
3113
1.09
0.75
1.3
1.2
13.19
13.70
u/ml
0.04
112
1148
34
262
1.30
0.74
1.1
1.2
—
—
—
0
0
29
219
1.33
0.73
1.6
1.6
—
—
—
0
0
14
92
1.53
0.72
1.0
1.1
—
—
—
0
0
27
204
1.33
0.69
3.2
3.7
—
—
—
0
0
30
231
1.30
0.67
1.2
1.2
8.00
1.67
u/ml
0.60
11
61
62
521
1.20
0.67
1.5
1.5
0.01
11.00
iu/ml
0.51
16
111
55
457
1.21
0.66
3.0
3.0
25.96
25.16
mmol/l
0.59
50
393
5
28
1.79
0.66
1.0
1.2
2.03
1.67
umol/24h
—
5
28
133
1485
0.89
0.65
2.5
2.6
57.35
63.34
ml/min/173m2
1.50
66
624
41
331
1.24
0.65
2.6
1.8
1.01
0.81
nmol/l
0.75
34
268
349
3277
1.08
0.62
1.3
1.3
33.38
38.11
iu/ml
0.26
98
1038
8
49
1.63
0.62
2.5
3.0
—
—
—
0
0
8
49
1.63
0.62
2.5
3.0
—
—
—
0
0
8
49
1.63
0.62
1.4
1.4
24.75
23.56
%
—
8
39
53
444
1.20
0.60
1.7
1.8
—
—
—
0
0
0
20
0.00
0.60
0.0
1.0
—
0.48
—
0
13
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
25
192
1.31
0.59
1.3
1.3
211286.05
108110.26
e6/l
0.27
19
128
30
377
0.79
0.59
1.3
1.3
170.17
231.77
miu/ml
0.60
13
167
23
175
1.32
0.58
1.5
1.5
—
—
—
0
0
10
150
0.67
0.58
1.5
1.5
—
—
—
0
0
15
106
1.42
0.57
1.2
1.1
81.10
76.72
u/l
—
10
83
21
158
1.33
0.57
1.0
1.2
87.10
96.13
%
0.94
21
148
12
81
1.48
0.57
1.1
1.1
—
—
—
0
0
46
384
1.20
0.56
2.3
2.4
17.13
15.86
%
1.10
23
186
26
203
1.28
0.55
1.6
1.5
—
—
—
0
0
15
107
1.40
0.55
1.2
1.1
19.67
24.43
u/l
—
9
82
6
38
1.58
0.54
1.7
1.2
1.47
121.44
mg/l
—
6
29
6
38
1.58
0.54
2.8
2.3
—
—
—
0
0
63
543
1.16
0.54
2.0
1.7
—
—
—
0
0
28
222
1.26
0.54
1.1
1.1
1.83
2.15
u/ml
—
10
80
44
369
1.20
0.52
3.2
3.6
60.86
57.55
%
1.25
44
369
104
935
1.12
0.50
4.5
3.2
26.21
25.49
mmol/l
1.76
99
910
30
243
1.24
0.49
1.8
1.5
—
—
—
0
0
15
110
1.37
0.48
1.3
1.4
—
—
—
0
0
15
110
1.37
0.48
1.3
1.4
—
—
—
0
0
20
154
1.30
0.48
1.2
1.6
—
—
—
0
0
29
235
1.24
0.48
1.1
1.1
—
—
—
0
0
17
128
1.33
0.47
1.8
2.0
6.51
7.49
umol/l
0.16
17
82
12
85
1.41
0.47
1.0
1.0
—
—
—
0
0
7
48
1.46
0.46
1.0
1.2
—
—
—
0
0
10
69
1.45
0.44
3.2
1.8
—
—
—
0
0
12
163
0.73
0.43
1.1
1.4
—
—
—
0
0
12
163
0.73
0.43
1.1
1.4
—
—
—
0
0
12
163
0.73
0.43
1.1
1.4
—
—
—
0
0
26
211
1.24
0.43
1.3
1.5
—
—
—
0
0
28
230
1.22
0.42
1.2
1.2
3.75
5.56
u/ml
0.42
16
88
6
91
0.66
0.42
1.0
1.3
—
—
—
0
0
55
481
1.15
0.42
1.1
1.2
3.58
6.43
u/ml
—
8
96
5
32
1.56
0.42
1.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
76
682
1.12
0.40
4.4
3.5
1.50
1.38
mmol/l
0.45
76
668
30
250
1.20
0.40
1.3
1.4
—
—
—
0
0
20
159
1.26
0.40
1.1
1.1
—
62.88
—
0
8
19
150
1.27
0.40
1.0
1.1
—
2.33
—
0
12
0
18
0.00
0.40
0.0
1.3
—
9.28
—
0
18
7
101
0.69
0.39
1.0
1.4
—
—
—
0
0
7
101
0.69
0.39
1.0
1.4
—
—
—
0
0
7
101
0.69
0.39
1.0
1.4
—
—
—
0
0
7
101
0.69
0.39
1.0
1.4
—
—
—
0
0
7
101
0.69
0.39
1.1
1.5
—
—
—
0
0
13
97
1.34
0.39
3.2
2.2
—
188.59
—
0
17
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
4.8
—
—
—
0
0
53
466
1.14
0.39
1.1
1.1
5.81
7.06
u/ml
—
7
41
119
1097
1.09
0.38
1.9
1.7
—
—
—
0
0
5
36
1.39
0.38
1.0
1.3
—
—
—
0
0
28
234
1.20
0.37
1.0
1.1
0.46
1.23
u/ml
—
9
85
9
69
1.31
0.37
2.2
2.6
789.56
1218.87
u/ml
—
9
69
8
115
0.69
0.37
1.1
1.4
1.39
1.12
promille
—
8
87
17
136
1.25
0.33
1.7
1.2
0.61
1.37
u/ml
—
10
61
355
3418
1.05
0.32
1.5
1.4
—
—
—
0
0
23
192
1.20
0.32
1.5
1.4
—
—
—
0
0
23
192
1.20
0.32
1.5
1.4
—
—
—
0
0
506
4913
1.04
0.31
4.5
4.5
0.00
0.00
estimate
0.80
191
1638
23
193
1.19
0.30
1.5
1.4
—
—
—
0
0
23
193
1.19
0.30
1.5
1.4
—
—
—
0
0
25
212
1.18
0.30
7.0
6.1
12.53
12.23
mg/l
0.12
25
198
11
141
0.78
0.29
1.5
1.4
—
—
—
0
0
41
461
0.89
0.29
4.5
3.2
7.90
7.70
mmol/l
0.28
41
452
16
130
1.23
0.28
1.4
1.2
2.48
2.15
mmol/l
0.44
16
124
15
184
0.81
0.28
1.2
1.5
—
—
—
0
0
61
555
1.10
0.28
2.0
1.8
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
13
103
1.26
0.28
1.2
1.1
—
—
—
0
0
34
386
0.88
0.28
1.4
1.3
162.40
24.53
e6/l
0.40
25
290
34
386
0.88
0.28
1.4
1.4
294.39
931.55
e6/l
0.98
28
310
21
248
0.85
0.28
5.9
4.9
378.38
364.62
umol/l
0.20
16
213
79
730
1.09
0.27
4.7
4.1
25.73
25.10
mmol/l
0.94
74
670
20
236
0.85
0.26
1.2
1.4
—
—
—
0
0
8
67
1.19
0.26
2.0
2.0
21.05
133.29
ug/l
—
8
60
40
446
0.89
0.25
1.3
1.2
676.35
522.69
mg/l
1.01
40
421
12
96
1.25
0.24
1.0
1.2
—
—
—
0
0
9
77
1.17
0.24
1.2
1.2
—
—
—
0
0
10
126
0.79
0.24
1.4
1.7
—
—
—
0
0
6
84
0.71
0.24
1.0
1.4
—
—
—
0
0
6
84
0.71
0.24
1.0
1.4
—
—
—
0
0
6
85
0.71
0.24
1.0
1.4
—
—
—
0
0
5
39
1.28
0.23
1.0
1.2
—
—
—
0
0
34
305
1.12
0.21
1.8
1.9
5006.57
2525.99
u/l
0.42
15
123
0
11
0.00
0.21
0.0
1.0
—
2.60
—
0
6
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
13.7
—
—
—
0
0
40
440
0.91
0.21
4.7
3.8
23.45
26.05
mg/l
0.17
24
278
0
12
0.00
0.21
0.0
1.3
—
22.62
—
0
5
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
7.25
—
0
13
0
13
0.00
0.21
0.0
1.0
—
38.00
—
0
13
0
13
0.00
0.21
0.0
1.0
—
20.66
—
0
13
0
13
0.00
0.21
0.0
1.0
—
0.02
—
0
8
17
198
0.86
0.20
1.2
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
0.04
—
0
9
0
14
0.00
0.20
0.0
1.0
—
0.03
—
0
9
16
136
1.18
0.20
1.0
1.2
—
—
—
0
0
6
51
1.18
0.19
1.2
1.1
1214.67
1766.16
miu/ml
—
6
51
6
52
1.15
0.19
1.7
1.4
7.13
8.83
ug/l
—
6
52
28
251
1.12
0.18
1.4
1.5
—
—
—
0
0
19
217
0.87
0.18
1.4
1.5
—
—
—
0
0
7
58
1.21
0.18
1.1
1.1
—
—
—
0
0
88
834
1.06
0.18
1.3
1.3
—
—
—
0
0
412
4034
1.03
0.17
4.9
4.6
1.02
1.02
kg/l
0.18
81
615
24
214
1.12
0.17
1.1
1.1
118.58
118.93
%
0.02
24
194
16
138
1.16
0.17
1.1
1.0
—
—
—
0
0
14
162
0.86
0.16
1.2
1.2
—
—
—
0
0
8
73
1.10
0.15
1.1
1.2
—
—
—
0
0
53
565
0.94
0.15
1.4
1.5
98.64
244.22
pmol/l
3.18
53
552
22
245
0.90
0.15
1.1
1.1
—
—
—
0
0
45
420
1.07
0.14
2.2
3.1
220.68
1001.26
u/ml
0.63
39
379
17
192
0.88
0.14
2.4
2.8
—
—
—
0
0
52
553
0.94
0.14
1.5
1.7
3.44
3.88
mg/l
0.13
39
403
33
304
1.09
0.14
1.7
1.9
1.68
1.63
mmol/l
0.13
33
295
14
122
1.15
0.13
1.4
2.0
—
—
—
0
0
25
272
0.92
0.12
1.2
1.4
—
—
—
0
0
70
732
0.95
0.12
1.9
1.9
0.68
1.93
ug/l
1.62
57
629
24
220
1.09
0.11
1.0
1.1
—
—
—
0
0
11
95
1.16
0.11
6.4
3.1
—
—
—
0
0
12
105
1.14
0.11
1.4
1.8
—
—
—
0
0
10
86
1.16
0.11
1.0
1.4
—
—
—
0
0
41
388
1.06
0.10
1.1
1.2
—
10.84
—
0
5
13
116
1.12
0.09
1.2
1.2
11.42
11.55
mmol/l
—
6
33
42
441
0.95
0.09
1.2
1.4
—
—
—
0
0
5
61
0.82
0.08
1.0
1.0
—
—
—
0
0
16
146
1.10
0.08
1.0
1.0
—
—
—
0
0
35
332
1.06
0.08
1.6
1.6
—
—
—
0
0
12
133
0.90
0.07
1.3
1.2
—
—
—
0
0
12
133
0.90
0.07
1.3
1.2
—
—
—
0
0
12
133
0.90
0.07
1.3
1.2
—
—
—
0
0
7
81
0.86
0.07
4.1
4.4
—
—
—
0
0
7
80
0.87
0.07
1.4
1.3
—
—
—
0
0
9
86
1.05
0.07
1.0
1.2
164.33
358.03
u/l
—
9
77
12
132
0.91
0.06
1.3
1.2
—
—
—
0
0
12
132
0.91
0.06
1.3
1.2
—
—
—
0
0
9
105
0.86
0.06
1.2
1.1
—
—
—
0
0
14
152
0.92
0.06
1.0
1.1
—
—
—
0
0
32
335
0.95
0.06
1.3
1.5
—
—
—
0
0
47
485
0.97
0.05
4.1
3.1
1.86
1.56
mmol/l
0.73
47
475
10
110
0.91
0.05
1.3
1.2
—
—
—
0
0
30
288
1.04
0.04
1.2
1.3
—
—
—
0
0
10
91
1.10
0.04
1.2
1.7
—
—
—
0
0
42
433
0.97
0.04
1.2
1.5
—
—
—
0
0
11
101
1.09
0.04
1.0
1.1
—
—
—
0
0
13
121
1.07
0.03
1.2
1.4
—
—
—
0
0
25
260
0.96
0.03
1.3
1.4
—
—
—
0
0
10
108
0.93
0.03
1.3
1.2
—
—
—
0
0
25
259
0.96
0.02
1.3
1.4
—
—
—
0
0
43
440
0.98
0.02
1.3
1.3
—
—
—
0
0
68
691
0.98
0.02
1.3
1.4
—
—
—
0
0
59
580
1.02
0.02
4.9
3.6
3.86
3.83
mmol/l
0.20
53
546
22
212
1.04
0.02
1.0
1.1
—
—
—
0
0
11
103
1.07
0.02
1.3
1.5
—
—
—
0
0
27
263
1.03
0.01
1.3
1.4
—
—
—
0
0
11
105
1.05
0.00
1.3
1.5
—
—
—
0
0
27
265
1.02
0.00
1.3
1.4
—
—
—
0
0
25
249
1.00
0.00
1.7
1.9
88.84
89.45
%
0.19
25
244
26
259
1.00
0.00
1.0
1.1
400.38
104.84
iu/ml
—
5
53
26
261
1.00
0.00
1.3
1.4
—
—
—
0
0
27
269
1.00
0.00
1.4
2.3
18.50
27.33
mg/l
—
8
71
10
104
0.96
0.00
2.1
2.5
—
—
—
0
0
18
176
1.02
0.00
1.3
1.4
0.37
0.25
nmol/l
—
8
129
18
182
0.99
0.00
2.8
3.2
61.33
55.15
%
—
9
116
27
267
1.01
0.00
1.3
1.4
—
—
—
0
0
31
313
0.99
0.00
1.3
1.4
—
—
—
0
0
11
107
1.03
0.00
1.4
1.8
11.33
12.10
%
—
6
39
14
143
0.98
0.00
1.9
1.7
5.24
4.10
mg/l
0.32
14
137
6
65
0.92
0.00
1.7
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
2.56
—
0
9
0
9
0.00
0.00
0.0
4.8
—
22.86
—
0
9
0
8
0.00
0.00
0.0
5.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.98
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXGOITMULT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITMULT | 1.258 [1.14, 1.39] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.248 |
During the follow-up period (1.1.1998 — 31.12.2019), 1886 out of 8353 females with E4_THYTOXGOITMULT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITMULT | 1.226 [1.04, 1.45] | 0.016 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 410 out of 1483 males with E4_THYTOXGOITMULT died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXGOITMULT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.142% | 0.251% |
| 5 | 0.77% | 1.437% |
| 10 | 1.909% | 3.544% |
| 15 | 3.56% | 6.687% |
| 20 | 6.338% | 11.5% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXGOITMULT – Thyrotoxicosis with toxic multinodular goitre
GWS hits: 22
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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