No definition available.
Disorder of pancreatic internal secretion, other and/or unspecified
DOID EFO Endpoint Browser PheWeb
E4_PANCSECNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
298 |
4. Check minimum number of eventsNone |
298 |
5. Include endpointsNone |
298 |
6. Filter based on genotype QC (FinnGen only) |
271 |
Control definitions (FinnGen only)
- Control exclude
- E4_GLUCOPANCREAS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorder of pancreatic internal secretion, other and/or unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of glucose regulation and pancreatic internal secretion
- Endocrine, nutritional and metabolic diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1896 | 1059 | 820 |
| Only index persons | 1511 | 896 | 615 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 44.97 | 39.12 | 52.19 |
| Only index persons | 42.06 | 36.45 | 50.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 271 | 169 | 102 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | 43.68 | 35.71 | 56.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 276
- Matched controls
- 2760
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
38.4
119.8
78
28
E16.9
ICD-10 Finland
Disorder of pancreatic internal secretion, unspecified
+∞
119.7
106
*
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
75.4
116.9
64
11
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
19.1
83.3
72
50
A10AB05
ATC
insulin aspart; parenteral
12.6
82.8
99
117
T89
ICPC
Diabetes insulin dependent
17.4
79.9
73
56
A10AE04
ATC
insulin glargine; parenteral
11.1
78.5
106
147
25109
ICD-8 Finland
Disorders of pancreatic internal secretion other than diabetes mellitus, Unspecified
+∞
72.1
66
*
A10AC01
ATC
insulin (human); parenteral
11.1
68.9
88
112
A10AB01
ATC
insulin (human); parenteral
18.5
68.6
59
40
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
27.4
64.8
46
20
A10AA02, ,
ATC
17.4
62.2
55
39
103
Kela drug reimbursment
Diabetes, insulin-treated
7.3
61.3
167
479
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
18.7
60.4
51
33
E16.89
ICD-10 Finland
Other specified disorders of pancreatic internal secretion
+∞
59.6
55
*
A10AE05
ATC
insulin detemir; parenteral
11.0
56.8
69
81
215
Kela drug reimbursment
Diabetes, non-insulin-treated
6.6
55.1
152
433
H04AA01
ATC
glucagon; nasal, parenteral
20.2
53.4
43
25
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
18.3
53.2
45
29
A10AA01, ,
ATC
17.6
53.2
46
31
A10AB04
ATC
insulin lispro; parenteral
14.7
49.1
47
38
A10AE06
ATC
insulin degludec; parenteral
12.0
45.6
50
50
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
16.4
40.7
36
25
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
434.5
39.1
38
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
14.3
33.7
32
25
SPAT1262
SPAT
Handing over of treatment supplies
4.5
27.5
88
262
XCK10
NOMESCO Finland
Photography of fundus of eye
5.4
27.1
63
144
E16.19
ICD-10 Finland
Other specified hypoglycaemia
+∞
25.4
24
*
H3603, E103,
ICD-10 Finland
142.9
25.1
26
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.7
24.2
112
428
T90
ICPC
Diabetes non-insulin dependent
3.7
24.1
114
441
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
49.7
22.8
27
6
K90.3
ICD-10 Finland
Pancreatic steatorrhoea
52.3
20.5
24
5
B03BA03
ATC
hydroxocobalamin; parenteral
5.7
17.7
35
68
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
19.0
17.3
26
15
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
16.7
62
199
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
43.0
16.6
20
5
K86.1
ICD-10 Finland
Other chronic pancreatitis
35.8
16.0
20
6
H3600, E103,
ICD-10 Finland
28.2
15.8
21
8
E16.0
ICD-10 Finland
Drug-induced hypoglycaemia without coma
+∞
15.8
15
*
A10BA02
ATC
metformin; oral
2.9
15.4
109
512
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
30.6
15.4
20
7
B81
ICPC
Anaemia vit B12/folate deficiency
6.4
15.1
26
44
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
15.0
69
254
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
12.9
14.9
26
22
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.7
14.3
35
82
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
25.4
14.0
19
8
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
13.7
111
553
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
36.1
13.7
17
5
2518X
ICD-9 Finland
Other disorders of pancreatic internal secretion, Other specified disorders of pancreatic internal secretion
+∞
13.7
13
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
52.6
13.0
15
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.7
12.7
44
134
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
6.0
12.6
23
41
E16.85
ICD-10 Finland
Zollinger-Ellison syndrome
+∞
12.6
12
*
25108
ICD-8 Finland
Disorders of pancreatic internal secretion other than diabetes mellitus, Alia definita
+∞
12.6
12
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.5
12.5
25
49
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
4.5
12.4
32
78
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
12.5
12.0
21
18
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.9
11.8
22
40
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
17.4
11.8
18
11
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.6
11.8
43
135
25009
ICD-8 Finland
Diabetes mellitus, Unspecified
36.7
11.4
14
*
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
5.9
11.4
21
38
R4110
NOMESCO Finland
Physiotherapy
2.4
11.1
105
554
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
45.2
11.0
13
*
ZXD05
NOMESCO Finland
Urgent procedure
2.4
10.9
103
541
H3601, E103,
ICD-10 Finland
29.4
10.8
14
5
Z3226
NOMESCO Finland
Physiotherapist
2.7
10.8
74
334
CKC12
NOMESCO Finland
Photocoagulation of retina
4.7
10.8
26
60
Y6099
ICD-8 Finland
Prenatal care and observation
4.0
10.8
32
87
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.8
10.5
62
259
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.5
10.5
21
41
2519X
ICD-9 Finland
Other disorders of pancreatic internal secretion, Unspecified disorder of pancreatic internal secretion
+∞
10.5
10
*
E16.80
ICD-10 Finland
Hypergastrinaemia
+∞
10.5
10
*
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
8.0
10.4
23
31
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.5
10.4
90
454
C03CA01
ATC
furosemide; systemic
2.4
10.3
101
538
177
Kela drug reimbursment
Insulin glargine 300 U / ml
9.7
10.2
20
22
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
10.2
73
336
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
9.9
44
156
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
9.9
59
247
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
27.2
9.9
13
5
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
9.8
65
287
ZXA00
NOMESCO Finland
Right side
2.3
9.7
95
504
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.6
9.5
23
53
A10BB12
ATC
glimepiride; oral
3.8
9.5
31
90
Z3231
NOMESCO Finland
Registered nurse
2.3
9.5
98
531
D64.9
ICD-10 Finland
Anaemia, unspecified
3.1
9.5
42
149
E13.8
ICD-10 Finland
Other specified diabetes mellitus, with unspecified complications
+∞
9.4
9
*
AA1AD
NOMESCO Finland
CT of head and brain
2.3
9.3
96
519
Z2446
NOMESCO Finland
Social worker
3.4
9.3
35
112
H43.1
ICD-10 Finland
Vitreous haemorrhage
8.8
9.2
19
23
A10AD01
ATC
insulin (human); parenteral
8.8
9.2
19
23
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.1
9.2
43
157
TPH07
NOMESCO Finland
Cathetrisation of artery
3.0
9.2
45
169
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
16.3
9.1
14
9
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
13.1
9.0
15
12
TK800
NOMESCO Finland
Hemodialysis
10.0
8.9
17
18
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
8.9
79
399
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
4.0
8.8
26
70
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.4
8.7
34
111
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.3
8.7
23
57
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
8.7
117
702
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
13.3
8.5
14
11
RJ410, ,
NOMESCO Finland
92.8
8.5
9
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.2
8.3
23
59
OAB50, ,
SPAT
3.1
8.3
36
126
G40.9
ICD-10 Finland
Epilepsy, unspecified
5.0
8.2
18
38
Z3229
NOMESCO Finland
Other healthcare associate professional
3.1
8.2
37
132
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.7
8.2
27
79
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
34.5
8.1
10
*
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
34.5
8.1
10
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.9
8.1
24
65
J01FF01
ATC
clindamycin; systemic
2.2
7.9
91
510
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
15.6
7.8
12
8
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
7.8
88
489
L84
ICD-10 Finland
Corns and callosities
4.7
7.8
18
40
E13
ICD-10 Finland
Other specified diabetes mellitus
46.3
7.8
9
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.6
7.7
26
77
Z2221
NOMESCO Finland
Medical doctor
2.1
7.7
92
521
L28
ICPC
Limited function/disability (L)
2.3
7.7
66
327
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.4
7.7
29
93
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
7.6
118
737
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.5
7.6
19
45
N03AX16
ATC
[U] pregabalin
2.2
7.5
80
433
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
7.5
87
487
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.8
7.4
41
164
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.0
7.3
35
129
E16.10
ICD-10 Finland
Hyperinsulinism
+∞
7.3
7
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
7.3
100
595
Z94.0
ICD-10 Finland
Kidney transplant status
16.3
7.3
11
7
K86.3
ICD-10 Finland
Pseudocyst of pancreas
30.9
7.2
9
*
WX002
NOMESCO Finland
Sedation and analgesia
2.3
7.1
65
329
H36.00
ICD-10 Finland
Diabetic background retinopathy
9.2
7.1
14
16
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.6
7.1
17
27
ZXE00
NOMESCO Finland
One hour or less
2.0
7.0
120
771
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
7.0
85
483
N02AX02
ATC
tramadol; systemic, rectal
2.0
7.0
131
869
C02AC05
ATC
moxonidine; oral
4.3
6.9
18
44
ZXE20
NOMESCO Finland
More than three and less than five hours
2.4
6.9
50
229
N06AB04
ATC
citalopram; systemic
2.2
6.9
70
371
K85
ICD-10 Finland
Acute pancreatitis
11.3
6.9
12
11
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
6.7
6.7
16
25
205
Kela drug reimbursment
Chronic hypertension
2.1
6.7
79
442
H36.01
ICD-10 Finland
Diabetic maculopathy
12.7
6.6
11
9
C10AC01
ATC
colestyramine; oral
5.6
6.6
18
34
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
6.5
34
132
RJ421, ,
NOMESCO Finland
71.4
6.5
7
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
14.8
6.4
10
7
A11CC03
ATC
alfacalcidol; systemic
6.8
6.4
15
23
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
6.4
109
694
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
6.4
140
969
ZXA05
NOMESCO Finland
Left side
2.1
6.4
80
458
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.5
6.3
22
67
5770D
ICD-9 Finland
Diseases of pancreas, Acute pancreatitis[PANCREATITIS ACUTA ALCOHOLICA NONHAEMORHAGICA]
+∞
6.3
6
*
H3603, E107,
ICD-10 Finland
+∞
6.3
6
*
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
27.4
6.3
8
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
27.4
6.3
8
*
H01CB02
ATC
octreotide; parenteral
27.4
6.3
8
*
WX892
NOMESCO Finland
Monitored bed care
3.0
6.2
28
100
JN3AD
NOMESCO Finland
Abdominal CT examination
2.5
6.2
43
193
A10AB06
ATC
insulin glulisine; parenteral
12.9
6.1
10
8
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
6.0
52
256
N05CD07
ATC
temazepam; oral
2.5
6.0
40
175
A02BC02
ATC
pantoprazole; systemic
2.0
6.0
196
1531
I20.09
ICD-10 Finland
Unstable angina
3.4
6.0
22
69
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
64
77
10.52
51.48
2.2
1.4
141.64
295.13
ug/g
6.13
38
47
38
51
8.48
27.45
2.0
1.4
0.63
0.85
nmol/l
0.65
29
44
154
800
3.09
18.97
7.5
4.1
7.33
9.32
mg/mmol
0.39
114
497
157
829
3.07
18.70
6.2
3.5
6.68
7.66
mmol/l
1.85
138
705
182
1060
3.11
17.89
8.8
4.9
34.44
36.08
g/l
3.52
175
1003
61
191
3.82
17.11
7.2
4.0
92.35
82.67
ng/l
0.39
51
171
67
253
3.18
13.84
2.0
1.9
424.80
369.10
nmol/l
1.47
61
239
89
417
2.67
12.22
6.1
3.9
0.80
0.82
mmol/l
0.68
84
400
49
174
3.21
11.07
2.3
1.5
—
—
—
0
0
133
780
2.36
11.02
4.6
2.5
48.52
68.10
u/l
1.64
123
716
181
1215
2.42
10.95
16.3
7.5
1.22
1.22
mmol/l
0.14
164
1057
22
44
5.35
10.71
1.2
1.2
1.86
2.50
iu/ml
—
7
6
167
1099
2.32
10.33
14.1
6.8
1.22
1.22
mmol/l
0.07
160
1023
139
858
2.25
9.91
3.9
3.2
29.70
32.55
u/l
0.57
131
806
166
1118
2.22
9.34
4.4
2.6
75.28
77.57
nmol/l
0.46
156
1003
21
30
7.48
9.22
5.3
3.7
31.80
2.99
nmol/l
0.87
21
30
106
600
2.24
9.18
3.4
2.2
2.61
2.92
mg/l
0.61
95
528
57
246
2.66
8.97
9.0
4.0
1.08
1.78
mmol/l
0.88
51
204
115
698
2.11
8.14
5.7
3.3
0.20
0.39
e6/l
1.29
93
503
104
616
2.10
7.79
1.8
1.3
0.94
1.27
u/ml
0.33
23
172
153
1045
2.04
7.75
3.3
2.1
94.03
97.31
pmol/l
0.27
82
517
68
340
2.33
7.74
10.3
7.1
104.46
103.93
mmol/l
0.46
68
340
56
257
2.48
7.71
9.1
4.0
5.98
5.75
kpa
1.16
51
248
71
371
2.23
7.24
2.0
1.7
1138.99
1233.04
nmol/l
0.38
56
283
130
859
1.97
7.02
3.8
3.4
2.36
2.36
mmol/l
0.15
119
778
55
263
2.36
6.88
7.5
10.0
0.92
0.76
mmol/l
0.09
46
227
188
1416
2.03
6.87
14.3
9.8
4.10
3.97
e9/l
0.38
158
1236
110
698
1.96
6.58
1.9
1.7
23.62
21.19
nmol/l
1.01
92
584
49
229
2.39
6.43
8.0
3.3
4.60
4.58
kpa
0.03
44
222
71
390
2.10
6.31
2.6
2.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
62
3.58
6.28
3.9
2.8
0.27
0.37
iu/ml
0.86
13
33
53
261
2.28
6.17
3.6
2.4
25.12
28.87
u/l
0.49
43
215
71
396
2.07
6.04
5.7
3.2
3.15
2.73
e6/l
0.10
42
183
114
750
1.89
6.00
3.2
2.2
146.47
208.96
u/l
0.85
105
717
57
297
2.16
5.76
2.4
1.9
—
—
—
0
0
80
473
1.97
5.76
5.0
3.8
113.00
284.42
ng/l
0.89
58
363
22
71
3.28
5.75
1.5
1.2
—
—
—
0
0
175
1329
1.87
5.73
9.5
6.4
9.66
11.53
umol/l
2.38
169
1255
93
581
1.91
5.68
1.7
1.8
1.07
1.54
mg/l
0.79
74
464
82
493
1.94
5.60
2.8
2.8
2.48
2.46
mmol/l
0.82
71
438
33
138
2.58
5.46
2.1
1.7
—
—
—
0
0
56
299
2.10
5.30
3.5
2.9
7.04
6.50
umol/l
0.11
50
266
65
370
1.99
5.16
2.7
2.1
28.61
29.08
s
0.37
65
361
15
41
3.81
4.99
2.0
1.4
—
—
—
0
0
15
41
3.81
4.99
2.0
1.4
—
—
—
0
0
88
567
1.81
4.75
3.8
2.4
—
—
—
0
0
150
1126
1.73
4.74
4.9
3.0
94.73
111.55
ug/l
1.06
143
1049
15
36
4.35
4.59
1.4
1.3
—
—
—
0
0
10
15
6.87
4.51
3.1
4.4
10.11
38.07
mu/l
—
10
15
14
32
4.55
4.50
1.2
1.2
—
—
—
0
0
17
55
3.23
4.44
3.2
3.0
157.68
118.34
ug/min
0.11
12
32
19
68
2.93
4.21
2.2
1.3
—
—
—
0
0
27
118
2.43
4.09
1.5
1.4
—
—
—
0
0
23
94
2.58
4.00
1.7
1.6
—
—
—
0
0
69
435
1.78
3.92
5.4
3.0
1.26
0.98
e6/l
0.28
39
220
7
8
8.94
3.79
1.0
1.0
—
—
—
0
0
7
8
8.94
3.79
1.0
1.0
—
—
—
0
0
10
22
4.67
3.46
3.5
1.9
-0.92
1.05
mmol/l
—
10
22
29
142
2.16
3.41
16.6
4.1
0.93
1.44
mmol/l
0.32
20
111
7
10
7.15
3.38
1.0
1.0
—
—
—
0
0
48
286
1.82
3.26
2.8
1.9
—
—
—
0
0
71
474
1.67
3.25
1.9
1.8
472.29
455.71
pmol/l
0.19
59
406
213
1853
1.65
3.08
14.7
8.0
89.02
79.52
u/l
2.10
208
1745
6
8
7.63
3.07
1.0
1.0
1507.83
1692.50
miu/ml
—
6
8
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
12
5.95
3.04
1.0
1.3
—
—
—
0
0
100
743
1.54
2.90
2.9
3.5
1708.70
1081.58
ng/l
0.71
86
635
46
281
1.76
2.88
2.0
1.8
1.91
1.53
%
0.88
39
242
13
47
2.85
2.86
2.3
1.5
—
—
—
0
0
16
65
2.55
2.84
4.3
2.7
2.00
2.00
index
0.00
11
40
86
620
1.56
2.84
3.9
2.8
342.81
338.92
umol/l
0.11
80
541
14
54
2.68
2.75
3.3
3.9
6.36
10.72
pmol/l
1.32
14
54
7
14
5.10
2.74
1.0
1.2
29.14
9.98
u/l
—
7
14
7
14
5.10
2.74
1.0
1.2
128.14
62.58
u/l
—
7
14
6
10
6.10
2.71
1.0
1.1
—
—
—
0
0
17
73
2.42
2.71
3.2
1.7
418.00
298.48
mu/l
0.43
17
67
12
43
2.87
2.68
2.8
1.5
153.33
159.58
au/ml
—
6
18
40
241
1.77
2.63
4.5
3.2
—
—
—
0
0
13
50
2.68
2.57
1.5
1.4
—
—
—
0
0
5
7
7.25
2.56
1.0
1.1
—
—
—
0
0
158
1316
1.47
2.52
5.6
3.8
0.03
0.00
estimate
0.49
39
265
31
177
1.85
2.42
1.2
1.2
132.48
151.45
u/ml
—
9
66
6
12
5.08
2.41
3.7
2.7
—
—
—
0
0
6
12
5.08
2.41
1.2
1.7
—
—
—
0
0
5
8
6.34
2.38
1.0
1.3
—
—
—
0
0
5
8
6.34
2.38
1.2
1.0
—
—
—
0
0
160
1347
1.45
2.35
5.6
3.9
0.00
0.01
estimate
0.50
30
254
158
1331
1.44
2.29
5.6
3.8
0.00
5.95
estimate
0.50
36
273
9
30
3.07
2.16
2.0
1.9
—
—
—
0
0
9
30
3.07
2.16
1.2
1.6
—
—
—
0
0
7
19
3.75
2.16
1.3
1.3
—
—
—
0
0
9
31
2.97
2.09
1.2
1.6
—
—
—
0
0
9
31
2.97
2.09
1.2
1.6
—
—
—
0
0
8
26
3.14
2.03
2.1
2.1
—
—
—
0
0
136
1132
1.40
2.02
3.7
2.8
—
—
estimate
—
0
0
5
11
4.61
1.95
1.0
1.2
—
—
—
0
0
210
2275
0.68
1.94
7.5
5.2
7.09
5.94
mmol/l
9.10
192
2108
12
52
2.37
1.90
1.8
1.5
—
—
—
0
0
21
115
1.89
1.89
2.0
1.3
0.26
0.32
mg/l
—
10
40
5
12
4.22
1.83
1.2
1.3
—
—
—
0
0
5
12
4.22
1.83
1.2
1.6
53.20
76.63
ng/l
—
5
12
27
162
1.74
1.83
11.2
9.5
1.53
1.29
%
0.42
27
162
13
61
2.19
1.74
1.2
1.9
—
—
—
0
0
8
30
2.72
1.73
1.3
1.6
—
—
—
0
0
8
30
2.72
1.73
1.3
1.6
—
—
—
0
0
8
31
2.63
1.67
1.3
1.6
—
—
—
0
0
5
14
3.62
1.62
1.4
4.8
113.00
87.43
%
—
5
14
235
2191
1.49
1.55
8.7
5.5
1.98
1.94
mu/l
0.19
224
2023
25
155
1.67
1.53
11.6
9.8
0.64
0.67
%
0.12
25
155
11
51
2.20
1.52
1.6
1.3
—
—
—
0
0
11
51
2.20
1.52
1.9
1.5
324.00
249.76
u/ml
—
5
25
182
1635
1.33
1.45
5.7
3.3
66.16
46.85
u/l
1.71
173
1538
10
46
2.22
1.41
2.5
1.6
—
—
—
0
0
11
53
2.12
1.40
1.7
1.3
—
—
—
0
0
7
29
2.45
1.40
1.7
2.1
—
—
—
0
0
15
82
1.88
1.38
2.2
2.1
—
—
—
0
0
8
34
2.39
1.30
4.9
4.3
—
—
—
0
0
28
188
1.54
1.27
2.7
2.5
2.75
8.04
ug/l
2.67
23
169
8
36
2.26
1.25
3.1
1.3
—
—
—
0
0
6
25
2.43
1.25
1.2
1.1
—
—
—
0
0
36
489
0.70
1.22
1.5
1.6
—
—
—
0
0
6
26
2.34
1.19
1.8
1.4
—
—
—
0
0
6
26
2.34
1.19
1.2
1.1
—
—
—
0
0
21
134
1.61
1.18
1.4
1.4
—
—
—
0
0
108
923
1.28
1.18
5.4
3.8
31.27
100.00
ng/l
0.56
86
639
13
73
1.82
1.13
2.7
1.6
—
—
—
0
0
234
2213
1.38
1.11
14.1
6.4
50.22
39.14
mmol/mol
20.75
225
2088
7
31
2.29
1.11
1.1
1.2
—
—
—
0
0
5
21
2.41
1.09
1.4
1.1
—
—
—
0
0
5
21
2.41
1.09
1.4
1.1
—
—
—
0
0
14
82
1.75
1.07
1.2
1.3
—
—
—
0
0
14
82
1.75
1.07
1.4
1.2
—
—
—
0
0
14
82
1.75
1.07
1.4
1.2
—
—
—
0
0
196
1814
1.28
1.05
6.8
4.4
14.95
11.48
mm/h
2.30
184
1680
5
22
2.30
1.04
1.2
1.4
—
—
—
0
0
7
34
2.09
1.03
2.3
1.2
—
—
—
0
0
13
76
1.75
1.00
6.9
3.6
1.08
2.71
ratio
—
8
37
10
54
1.88
0.98
3.3
2.4
300.82
13142.19
u/l
—
5
21
7
36
1.97
0.97
1.0
1.1
—
—
—
0
0
28
201
1.44
0.96
1.7
1.5
—
—
—
0
0
10
55
1.85
0.93
1.3
1.2
4.83
3.72
mmol/l
—
10
49
20
135
1.52
0.92
1.0
1.1
—
—
—
0
0
84
716
1.25
0.91
4.7
3.1
0.00
0.00
estimate
0.50
30
216
200
1871
1.25
0.89
6.9
4.4
15.03
14.75
pmol/l
0.89
188
1706
17
250
0.66
0.88
1.9
2.0
3.19
3.48
ratio
0.53
12
219
25
179
1.44
0.88
2.0
2.6
—
19.83
—
0
13
8
45
1.80
0.85
1.0
1.2
13.54
17.17
u/l
—
8
39
10
57
1.78
0.84
2.3
1.4
—
—
—
0
0
12
76
1.61
0.73
3.3
1.6
—
—
—
0
0
12
77
1.58
0.69
2.6
1.9
—
—
—
0
0
5
27
1.87
0.69
2.2
1.7
—
—
—
0
0
5
27
1.87
0.69
2.2
1.7
—
—
—
0
0
5
27
1.87
0.69
2.2
1.7
—
—
—
0
0
5
27
1.87
0.69
1.2
1.7
—
—
—
0
0
230
2210
1.24
0.65
5.6
4.4
1.35
1.28
mmol/l
0.42
212
2050
5
30
1.68
0.61
2.0
1.5
—
—
—
0
0
11
72
1.55
0.60
1.4
1.7
—
—
—
0
0
8
52
1.55
0.60
2.5
1.4
—
—
—
0
0
33
405
0.79
0.59
1.5
1.4
—
—
—
0
0
10
66
1.53
0.53
1.3
1.2
625.10
481.77
mg/l
—
10
61
246
2396
1.25
0.50
41.0
18.2
138.94
139.75
mmol/l
5.16
246
2346
246
2399
1.23
0.47
41.4
18.3
4.05
3.97
mmol/l
4.93
246
2345
5
82
0.60
0.46
1.0
1.1
0.86
0.92
g/l
—
5
82
5
83
0.60
0.46
1.6
1.4
—
—
—
0
0
250
2549
0.80
0.45
50.6
23.7
129.22
135.34
g/l
8.07
250
2524
9
126
0.70
0.44
1.4
2.1
—
—
—
0
0
5
31
1.62
0.43
2.2
1.8
10.60
10.77
mmol/l
—
5
31
250
2547
0.80
0.42
50.1
23.5
4.35
4.50
e12/l
3.66
244
2492
250
2547
0.80
0.42
50.7
24.0
38.77
40.44
%
5.18
250
2520
8
57
1.42
0.42
1.4
1.3
67.38
18.92
e6/l
—
8
39
5
32
1.57
0.42
1.2
1.3
—
—
—
0
0
241
2351
1.20
0.41
34.6
15.4
26.78
22.66
mg/l
1.03
215
1896
8
59
1.37
0.41
1.5
1.3
2.63
191.55
e6/l
—
8
42
250
2546
0.81
0.41
50.1
23.5
90.66
91.01
fl
0.56
250
2522
230
2236
1.17
0.41
31.5
15.1
80.17
81.14
ml/min/173m2
0.25
219
2066
65
584
1.15
0.40
4.2
4.0
1.02
1.02
kg/l
0.06
49
382
8
61
1.32
0.40
1.0
1.3
—
—
—
0
0
5
36
1.40
0.38
1.0
1.1
—
—
—
0
0
9
71
1.28
0.36
1.6
1.4
—
—
—
0
0
6
42
1.44
0.36
1.5
1.1
—
—
—
0
0
11
82
1.36
0.34
1.5
1.2
—
—
—
0
0
11
82
1.36
0.34
6.0
2.7
—
—
—
0
0
6
86
0.69
0.33
1.2
1.3
—
1.60
—
0
5
112
1056
1.10
0.31
2.8
1.9
1.34
1.37
mmol/l
0.08
97
883
27
231
1.19
0.31
2.4
1.9
—
—
—
0
0
7
54
1.30
0.30
5.7
3.7
15.29
29.96
u/ml
—
7
54
23
195
1.20
0.29
4.0
2.7
74.40
64.98
ml/min/173m2
—
10
84
53
481
1.13
0.29
1.3
1.3
41.37
24.20
iu/ml
0.57
16
146
8
67
1.20
0.26
3.0
1.5
—
—
—
0
0
45
492
0.90
0.23
3.8
4.3
19.84
20.75
%
0.19
20
226
5
38
1.32
0.23
1.2
1.1
—
1.33
u/ml
—
0
15
5
40
1.25
0.22
3.2
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
2.9
—
213.36
—
0
11
0
10
0.00
0.21
0.0
1.2
—
8.90
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
156
1513
1.07
0.20
3.2
3.1
—
—
—
0
0
79
748
1.08
0.20
5.8
3.9
0.00
0.00
estimate
-0.00
34
247
104
999
1.07
0.17
4.9
3.7
0.03
0.01
estimate
0.31
31
220
29
263
1.11
0.17
11.2
6.6
—
—
—
0
0
47
438
1.09
0.17
1.3
1.3
26.31
8.84
u/ml
0.64
20
173
5
67
0.74
0.17
1.2
1.3
—
55.24
—
0
11
5
68
0.73
0.17
1.2
1.3
—
1.03
—
0
6
36
381
0.94
0.10
3.0
2.9
0.57
0.74
ug/l
0.97
28
231
196
1982
0.96
0.08
43.1
20.1
330.11
332.21
g/l
2.24
196
1972
7
65
1.08
0.08
16.6
3.1
3.86
3.98
mmol/l
—
7
65
7
80
0.87
0.07
1.3
1.4
—
6.71
—
0
20
237
2353
1.05
0.07
8.3
6.0
2.26
2.73
mmol/l
14.37
225
2193
246
2475
0.94
0.07
42.5
20.0
81.58
75.14
umol/l
1.33
246
2444
27
256
1.06
0.06
2.6
2.1
—
—
—
0
0
9
105
0.85
0.06
1.3
2.0
—
—
—
0
0
232
2309
1.03
0.03
6.9
5.2
1.43
1.50
mmol/l
1.52
217
2151
231
2318
0.98
0.01
7.0
5.3
4.19
4.69
mmol/l
10.46
216
2169
30
296
1.02
0.00
7.2
4.7
33.62
32.02
%
0.26
21
194
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
20.45
—
0
8
6
66
0.91
-0.00
3.5
1.9
240.33
217.23
pmol/l
—
6
61
0
6
0.00
-0.00
0.0
1.0
—
0.17
—
0
6
0
6
0.00
-0.00
0.0
2.8
—
158.83
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
3.2
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
6.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PANCSECNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PANCSECNAS | 2.933 [2.09, 4.12] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 166 out of 473 females with E4_PANCSECNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PANCSECNAS | 4.546 [3.15, 6.57] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 479 males with E4_PANCSECNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_PANCSECNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.191% | 0.945% |
| 5 | 1.541% | 5.339% |
| 10 | 4.135% | 12.739% |
| 15 | 7.215% | 22.267% |
| 20 | 12.337% | 36.003% |
Relationships between endpoints
↥Index endpoint: E4_PANCSECNAS – Disorder of pancreatic internal secretion, other and/or unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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