Syndrome of inappropriate secretion of antidiuretic hormone

E4_ANTIDIU

inappropriate ADH syndrome: A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E22.2
  • Hospital discharge: ICD-9 2536X
  • Cause of death: ICD-10 E22.2
  • Cause of death: ICD-9 2536X

2 out of 7 registries used, show all original rules.

232

4. Check minimum number of events

None

232

5. Include endpoints

None

232

6. Filter based on genotype QC (FinnGen only)

199

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E22
Name in latin
Syndroma secretionis impropriae hormonis antidiuretici

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1631 971 648
Only index persons 1405 854 551
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 71.56 74.37 67.48
Only index persons 72.04 74.92 67.57

-FinnGen-

Key figures

All Female Male
Number of individuals 199 108 91
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 70.18 71.25 68.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
205
Matched controls
2050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
4503599627370496.0
272.6
197
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
88.1
232.5
146
56
AA1AD
NOMESCO Finland
CT of head and brain
3.5
17.7
108
493
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.4
17.6
32
58
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
6.9
15.9
26
42
H02AB09
ATC
hydrocortisone; systemic
20.3
15.1
22
12
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
161.0
14.7
15
*
R11
ICD-10 Finland
Nausea and vomiting
4.0
11.3
36
104
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
46.0
11.1
13
*
N03AX14
ATC
levetiracetam; systemic
9.3
10.9
22
26
N03AG01
ATC
valproic acid; systemic, rectal
5.0
10.1
23
51
G40.9
ICD-10 Finland
Epilepsy, unspecified
5.3
10.0
21
43
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
10.0
59
251
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
9.9
70
327
S06.3
ICD-10 Finland
Focal brain injury
18.6
9.5
14
8
N30.0
ICD-10 Finland
Acute cystitis
3.0
9.3
49
195
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
12.3
9.2
16
14
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
9.1
53
222
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.9
8.9
49
199
N05BA04
ATC
oxazepam; oral
2.5
8.7
74
374
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
93.8
8.5
9
*
N06AX11
ATC
mirtazapine; oral
2.4
8.4
89
496
2536X
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other disorders of neurohypophysis
+∞
8.4
8
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
8.4
8
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
8.1
8.4
18
24
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.4
8.3
22
55
R53
ICD-10 Finland
Malaise and fatigue
2.4
8.1
77
408
J01EA01
ATC
trimethoprim; systemic
2.4
7.7
73
385
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.3
7.5
91
532
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
7.3
39
155
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
8.4
7.2
15
19
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
31.2
7.2
9
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
9.3
7.2
14
16
N05CF01
ATC
zopiclone; oral
2.2
7.1
88
517
A06AD11
ATC
lactulose; oral
2.6
7.0
49
223
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.0
6.8
32
118
G41.9
ICD-10 Finland
Status epilepticus, unspecified
41.5
6.8
8
*
H02AA02
ATC
fludrocortisone; oral
12.8
6.7
11
9
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.0
6.5
19
51
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
6.3
6
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.0
6.3
29
106
N05BA01
ATC
diazepam; systemic, rectal
2.6
6.2
40
175
R42
ICD-10 Finland
Dizziness and giddiness
2.2
6.2
67
370
M05BX04
ATC
denosumab; parenteral
3.3
6.2
24
79
J01MA02
ATC
ciprofloxacin; systemic
2.1
6.1
97
620

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
70
22
47.80
112.74
2.5
1.2
261.12
266.06
mosm/kgh2o
0.25
60
17
130
171
19.05
106.53
3.5
1.9
413.24
396.42
nmol/l
0.33
117
156
136
386
8.50
52.06
5.0
3.4
446.81
527.37
mosm/kgh2o
4.73
120
332
34
14
28.78
25.35
1.4
1.3
25.09
25.43
ng/l
0.03
34
14
27
36
8.49
19.58
3.7
2.6
—
—
—
0
0
115
618
2.96
13.15
5.7
3.7
—
—
—
0
0
101
506
2.96
13.14
3.2
2.1
2.66
3.01
mg/l
1.00
86
434
152
954
3.29
13.08
11.2
6.9
1.20
1.21
mmol/l
1.02
128
819
106
562
2.83
12.17
6.1
4.5
—
—
—
0
0
21
37
6.21
11.74
3.6
2.6
4.69
5.04
kpa
1.68
21
37
21
37
6.21
11.74
3.6
2.6
8.99
8.03
kpa
1.85
21
37
21
37
6.21
11.74
3.5
2.6
1.97
2.75
mmol/l
0.91
16
23
38
116
3.79
11.05
9.8
7.9
24.36
24.64
mmol/l
0.16
38
116
108
606
2.65
10.70
2.9
2.2
751.20
223.71
u/l
0.45
103
572
25
58
4.77
10.37
3.9
2.7
7.42
7.41
ph
0.61
25
58
68
312
2.76
9.95
3.1
2.3
2.39
2.25
g/l
1.25
63
288
125
777
2.56
9.68
3.9
2.8
141.06
130.60
ug/l
0.18
106
712
103
591
2.49
9.40
4.1
2.6
53.99
62.53
u/l
0.52
96
543
64
294
2.71
9.26
3.2
2.3
16.90
21.64
%
2.68
58
276
50
205
2.90
8.94
5.7
3.8
7.38
7.38
ph
0.23
32
131
36
122
3.37
8.88
4.9
2.8
1.21
1.24
%
0.08
36
122
68
330
2.59
8.75
3.2
2.4
10.32
12.51
umol/l
1.84
62
306
147
1016
2.58
8.64
11.4
9.6
5.00
4.22
e9/l
2.45
130
881
35
119
3.34
8.58
4.9
2.7
0.63
0.62
%
0.10
35
119
101
598
2.36
8.32
6.6
4.0
7.40
7.40
ph
0.28
78
414
131
872
2.39
8.17
12.2
6.1
1.20
1.21
mmol/l
0.81
122
798
127
839
2.35
7.99
7.6
5.8
2.27
2.64
%
1.36
120
776
129
861
2.34
7.88
5.5
4.7
33.66
35.19
g/l
2.38
119
798
126
836
2.32
7.76
7.8
6.0
9.39
8.92
%
0.79
119
778
55
257
2.56
7.53
8.8
6.7
1.31
1.16
mmol/l
0.09
43
207
24
69
3.81
7.53
2.1
5.9
27.92
93.05
mg/l
0.74
19
62
24
69
3.81
7.53
2.1
5.9
29.15
60.25
mg/l
1.07
19
62
125
834
2.28
7.49
7.4
5.9
61.62
58.43
%
2.07
118
788
125
835
2.27
7.46
7.9
5.9
0.65
0.64
%
0.08
116
772
126
847
2.27
7.37
7.8
6.0
22.63
26.58
%
3.88
121
795
54
257
2.49
7.08
9.4
6.7
7.42
7.41
ph
0.29
33
165
50
231
2.54
6.97
9.4
7.0
94.83
95.15
%
0.11
45
223
33
124
2.98
6.81
5.3
3.6
7.42
7.42
ph
0.02
28
107
134
944
2.21
6.71
8.1
6.0
0.16
0.19
e9/l
1.18
119
816
68
370
2.25
6.53
2.2
1.7
1676.83
1233.68
nmol/l
1.62
40
271
134
950
2.19
6.53
19.2
15.8
1.26
1.30
inr
0.37
117
787
131
924
2.16
6.42
8.3
6.0
1.57
1.90
e9/l
1.98
117
815
118
800
2.12
6.41
6.4
4.3
56.28
83.31
ng/l
0.27
106
621
40
174
2.61
6.26
12.1
7.9
—
—
—
0
0
101
650
2.09
6.26
3.4
3.4
2.33
2.36
mmol/l
1.12
92
581
15
25
6.38
6.12
3.9
2.8
—
—
—
0
0
129
915
2.11
6.10
7.9
5.9
0.04
0.04
e9/l
0.01
116
779
21
64
3.54
6.05
2.1
5.3
1.22
3.42
ratio
1.17
12
36
128
907
2.09
6.04
8.2
5.9
0.63
0.60
e9/l
0.66
115
773
14
22
6.74
5.97
1.7
1.4
91.56
89.45
%
0.68
14
22
9
6
15.60
5.96
1.0
1.2
153.18
139.11
mmol/24h
—
9
6
89
555
2.07
5.93
6.3
3.5
0.45
0.53
e6/l
0.13
77
403
17
37
4.91
5.63
2.4
7.6
—
—
—
0
0
91
586
1.99
5.43
7.3
5.6
—
—
—
0
0
136
1010
2.03
5.35
8.9
6.5
10.30
11.16
umol/l
0.46
128
952
31
133
2.57
4.96
8.4
4.0
—
—
—
0
0
14
29
5.10
4.91
5.3
1.8
9.15
7.09
pmol/l
0.26
14
29
34
155
2.43
4.79
5.9
4.5
0.54
0.60
%
0.12
13
56
47
247
2.17
4.77
2.8
3.7
1.89
1.83
%
0.15
37
221
34
156
2.41
4.73
6.4
4.8
0.08
0.20
%
0.51
12
49
95
648
1.87
4.58
6.5
3.6
37.68
164.67
e6/l
0.68
83
497
32
147
2.39
4.43
2.4
3.1
—
—
—
0
0
103
726
1.84
4.43
7.8
4.5
0.00
0.02
estimate
0.50
38
156
102
718
1.84
4.39
7.1
4.3
201.90
112.57
e6/l
0.42
85
509
37
185
2.22
4.22
2.6
4.1
73.98
70.69
e9/l
0.23
25
144
128
980
1.82
4.06
7.3
4.5
0.02
0.00
estimate
0.49
47
182
125
956
1.79
3.92
7.3
4.5
0.00
0.00
estimate
-0.00
48
197
126
966
1.79
3.92
7.3
4.5
0.00
8.12
estimate
0.50
48
200
82
556
1.79
3.88
7.7
4.4
0.00
0.01
estimate
0.50
42
173
34
170
2.20
3.87
6.6
4.6
0.83
0.85
%
0.02
12
63
22
90
2.62
3.87
1.5
1.2
—
—
—
0
0
156
1281
1.91
3.82
7.2
4.3
16.02
15.03
pmol/l
3.89
145
1142
11
24
4.78
3.80
4.4
3.4
6.17
4.82
e9/l
0.66
11
24
163
1362
1.96
3.73
12.5
8.3
85.33
79.53
u/l
0.75
155
1273
16
56
3.01
3.72
3.1
2.1
124.06
123.76
g/l
0.02
16
41
33
167
2.16
3.65
7.3
5.0
0.10
0.25
%
—
10
51
83
573
1.75
3.65
2.1
1.7
23.29
21.16
nmol/l
0.62
73
470
20
81
2.63
3.59
1.3
1.3
—
49.67
—
0
6
8
13
6.35
3.53
1.5
1.8
—
—
—
0
0
76
516
1.75
3.51
7.4
3.9
0.00
0.00
estimate
-0.00
40
150
103
762
1.71
3.49
25.0
12.4
0.00
0.00
e9/l
0.30
88
618
13
37
3.68
3.47
4.2
3.0
1.17
1.20
mmol/l
1.53
13
37
13
37
3.68
3.47
4.2
3.0
4.27
4.06
mmol/l
1.50
13
37
13
37
3.68
3.47
4.2
3.0
96.00
105.51
mmol/l
2.45
13
37
11
27
4.24
3.45
1.8
1.5
—
—
—
0
0
30
151
2.16
3.36
7.5
5.6
24.80
24.25
mmol/l
0.35
25
143
12
33
3.80
3.35
1.4
1.4
—
—
—
0
0
38
211
1.98
3.29
1.8
1.7
—
—
—
0
0
11
29
3.95
3.24
1.4
3.3
32.82
31.97
pg
0.22
11
29
42
243
1.92
3.23
1.3
1.2
—
—
—
0
0
17
67
2.68
3.22
1.3
1.1
—
—
—
0
0
7
11
6.54
3.21
1.3
1.3
—
—
—
0
0
63
417
1.74
3.13
3.1
2.9
2.46
2.46
mmol/l
0.08
56
369
17
68
2.64
3.13
1.7
1.4
0.26
0.38
mg/l
—
9
27
102
769
1.65
3.10
5.6
4.1
6.53
6.25
ph
1.67
62
432
31
164
2.05
3.06
4.4
2.5
0.19
0.21
g/l
0.88
24
153
28
143
2.11
3.03
4.8
3.9
—
—
—
0
0
60
396
1.73
3.00
9.0
5.5
—
—
—
0
0
5
5
10.20
2.99
1.0
1.0
—
—
—
0
0
36
203
1.94
2.98
3.1
3.1
6.25
7.64
umol/l
0.36
28
169
26
134
2.08
2.75
3.3
3.1
82.98
79.15
ng/l
0.07
18
115
57
382
1.68
2.67
2.3
1.9
467.76
54717448.18
pmol/l
0.74
45
318
12
41
3.04
2.67
5.3
3.2
69.42
58.60
%
1.76
12
41
29
159
1.96
2.60
1.5
1.5
—
—
—
0
0
7
17
4.22
2.38
2.3
1.8
16.56
15.49
%
—
7
17
7
17
4.22
2.38
1.0
1.2
—
—
—
0
0
12
47
2.65
2.31
1.2
1.7
—
—
—
0
0
17
81
2.20
2.19
1.9
1.1
—
—
—
0
0
18
88
2.15
2.19
2.7
2.6
—
—
—
0
0
9
31
2.99
2.10
1.4
1.4
—
—
—
0
0
35
221
1.70
2.02
1.5
1.3
336.00
506.67
titre
—
10
57
105
853
1.47
2.01
2.8
2.2
94.87
96.18
pmol/l
0.10
54
425
5
11
4.63
1.95
1.0
1.4
—
—
—
0
0
6
16
3.83
1.95
1.7
1.1
—
—
—
0
0
17
86
2.07
1.91
1.2
1.2
26.88
167.02
u/ml
—
5
28
101
824
1.44
1.84
3.6
2.8
—
—
estimate
—
0
0
20
111
1.89
1.76
15.4
8.9
15.42
15.38
%
0.02
20
105
35
230
1.63
1.75
1.9
1.6
—
—
—
0
0
5
13
3.91
1.72
2.0
1.8
41.50
38.75
%
—
5
13
30
190
1.68
1.72
1.7
1.5
—
—
—
0
0
17
90
1.97
1.71
6.1
3.6
—
—
—
0
0
5
14
3.63
1.62
1.0
1.1
—
—
—
0
0
60
454
1.45
1.59
1.4
1.3
—
—
—
0
0
6
21
2.91
1.51
1.0
1.0
—
—
—
0
0
40
282
1.52
1.49
2.1
1.9
—
—
—
0
0
11
52
2.18
1.47
1.2
1.1
—
—
—
0
0
7
28
2.55
1.46
1.1
1.3
—
—
—
0
0
18
103
1.82
1.46
1.4
1.4
—
—
—
0
0
6
22
2.78
1.44
1.3
1.6
6.00
9.31
mmol/l
—
6
22
75
601
1.39
1.43
3.3
2.4
—
—
—
0
0
55
418
1.43
1.41
1.7
1.7
1.64
1.52
mg/l
0.11
46
337
48
356
1.45
1.40
1.6
1.5
4.06
2.63
g/l
0.44
30
199
44
321
1.47
1.40
5.5
3.3
0.88
2.49
e6/l
1.79
30
167
179
1666
1.59
1.39
37.0
18.3
25.55
25.81
mg/l
0.04
169
1406
6
23
2.66
1.37
5.5
4.2
—
—
—
0
0
27
177
1.61
1.37
1.6
1.4
—
—
—
0
0
5
17
2.99
1.36
1.6
1.8
—
—
—
0
0
0
39
0.00
1.35
0.0
1.1
—
—
—
0
0
61
477
1.40
1.33
2.6
3.2
306.07
352.68
umol/l
2.14
45
402
167
1537
1.47
1.32
8.5
5.4
1.92
2.01
mu/l
0.49
158
1386
59
460
1.40
1.31
6.9
4.0
83.75
87.42
%
0.55
59
455
25
163
1.61
1.30
3.8
3.9
7.37
7.34
ph
0.57
19
108
5
18
2.82
1.29
3.6
1.2
—
—
nmol/l
—
0
0
51
389
1.41
1.28
1.4
1.3
3.47
1.14
u/ml
0.43
16
98
63
502
1.37
1.22
4.6
3.6
0.00
0.12
—
6
17
5
19
2.67
1.22
1.4
1.2
—
—
—
0
0
33
234
1.49
1.21
2.2
1.4
—
—
—
0
0
12
64
1.93
1.20
8.9
6.6
—
—
—
0
0
5
20
2.54
1.16
1.0
1.5
—
—
—
0
0
7
31
2.30
1.11
4.0
2.3
7.86
10.26
mmol/l
—
7
31
75
624
1.32
1.08
3.3
3.2
5.35
7.32
mmol/l
6.40
63
511
9
49
1.87
1.00
1.9
1.2
0.18
0.24
g/l
—
9
49
0
29
0.00
0.98
0.0
1.2
—
1.59
—
0
29
10
54
1.90
0.98
1.9
1.4
171.60
274.22
ug/g
—
5
30
0
30
0.00
0.98
0.0
1.2
—
0.95
—
0
30
7
36
1.98
0.98
6.4
3.9
0.64
1.00
%
—
7
31
73
613
1.30
0.97
3.3
3.2
38.13
45.72
mg/l
0.15
47
407
9
51
1.80
0.96
16.8
12.6
—
—
—
0
0
75
634
1.29
0.95
4.4
3.9
8.01
8.38
mg/mmol
0.03
49
401
6
27
2.26
0.94
1.2
1.6
—
—
—
0
0
15
94
1.64
0.93
1.5
1.3
84.35
313.48
u/ml
0.76
15
85
6
29
2.10
0.90
2.7
2.0
—
—
—
0
0
8
43
1.89
0.88
1.1
1.2
—
58.00
—
0
5
24
171
1.46
0.88
2.3
2.1
0.00
0.00
estimate
—
8
33
0
26
0.00
0.79
0.0
1.0
—
—
—
0
0
0
28
0.00
0.76
0.0
1.2
—
0.66
—
0
8
30
230
1.36
0.75
4.5
3.3
5.15
5.55
e9/l
0.14
23
198
13
84
1.58
0.74
4.0
2.9
—
—
—
0
0
5
25
2.02
0.73
1.2
1.4
—
—
—
0
0
29
224
1.34
0.70
3.7
4.0
7.55
38.68
ug/l
0.53
24
190
24
180
1.38
0.69
2.9
2.6
5.14
5.33
ug/l
0.05
18
160
152
1601
0.80
0.64
5.5
5.2
1.56
1.47
mmol/l
1.81
137
1451
177
1698
1.31
0.63
32.6
15.8
—
—
—
0
0
13
88
1.51
0.62
1.6
1.6
—
—
—
0
0
28
349
0.77
0.59
2.4
3.2
0.65
0.76
ug/l
0.66
22
237
10
149
0.65
0.59
1.4
1.5
—
—
—
0
0
63
550
1.21
0.58
3.5
3.6
—
—
—
0
0
21
270
0.75
0.55
1.4
1.3
5.04
9.89
u/ml
—
5
97
13
91
1.46
0.54
2.8
2.1
—
—
—
0
0
158
1641
0.84
0.45
6.3
6.2
2.36
2.59
mmol/l
2.86
144
1497
183
1779
1.27
0.43
52.8
27.3
7.16
6.89
e9/l
0.85
178
1735
183
1779
1.27
0.43
52.7
27.3
4.12
4.41
e12/l
11.97
178
1733
6
95
0.62
0.43
1.3
1.4
—
—
—
0
0
8
59
1.37
0.41
1.0
1.1
—
—
—
0
0
19
152
1.28
0.38
2.6
2.6
247.39
224.40
ng/l
0.08
19
135
155
1606
0.86
0.38
5.4
5.4
4.24
4.53
mmol/l
2.79
140
1469
14
107
1.33
0.38
1.4
1.4
—
—
—
0
0
77
708
1.14
0.37
2.4
2.2
—
—
—
0
0
6
44
1.37
0.34
1.2
1.4
—
—
—
0
0
61
559
1.13
0.30
7.6
6.8
—
—
—
0
0
65
699
0.90
0.27
2.2
2.0
1.28
1.30
mmol/l
0.09
54
573
5
39
1.29
0.23
8.4
7.5
98.40
104.65
mmol/l
—
5
34
5
39
1.29
0.23
8.4
7.5
12.20
11.41
mmol/l
—
5
34
5
40
1.26
0.22
3.6
3.1
623.40
37.08
u/ml
—
5
40
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
11
89
1.25
0.21
1.1
1.2
—
—
—
0
0
5
43
1.17
0.21
1.2
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
16
138
1.17
0.18
1.1
1.6
—
—
—
0
0
15
131
1.16
0.15
1.3
1.2
—
—
—
0
0
46
437
1.07
0.11
7.3
4.7
1.01
1.02
kg/l
2.15
33
300
5
45
1.11
0.10
1.8
1.6
—
—
—
0
0
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
163
1610
1.06
0.09
6.1
5.6
6.11
6.08
mmol/l
0.09
145
1454
6
58
1.04
0.08
1.7
1.2
—
—
—
0
0
151
1526
0.96
0.06
4.4
4.5
1.13
1.28
mmol/l
2.43
135
1373
160
1586
1.04
0.05
8.2
7.1
40.92
40.16
mmol/mol
0.39
148
1473
30
291
1.04
0.02
1.4
1.3
19.08
29.35
iu/ml
0.95
13
94
60
609
0.98
0.02
4.6
5.7
1.93
2.53
ug/l
0.68
53
539
21
207
1.02
0.00
1.3
1.3
—
—
—
0
0
23
225
1.03
0.00
1.5
1.3
—
—
—
0
0
10
95
1.06
0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
62.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
27.20
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
0.59
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
645.40
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
2.40
—
0
5

Mortality – FinRegistry

Association

Association between endpoint E4_ANTIDIU and mortality.

Females

Parameter HR [95% CI] p-value
E4_ANTIDIU 2.117 [1.65, 2.72] < 0.001
Birth year 0.994 [0.98, 1.0] 0.177

During the follow-up period (1.1.1998 — 31.12.2019), 348 out of 767 females with E4_ANTIDIU died.

Males

Parameter HR [95% CI] p-value
E4_ANTIDIU 3.366 [2.32, 4.88] < 0.001
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 270 out of 507 males with E4_ANTIDIU died.

Mortality risk

Mortality risk for people of age

years, who have E4_ANTIDIU.

N-year risk Females Males
1 0.198% 0.597%
5 1.064% 3.778%
10 2.882% 8.794%
15 5.999% 16.438%
20 10.228% 26.295%

Relationships between endpoints

Index endpoint: E4_ANTIDIU – Syndrome of inappropriate secretion of antidiuretic hormone

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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