hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
276 |
4. Check minimum number of eventsNone |
276 |
5. Include endpointsNone |
276 |
6. Filter based on genotype QC (FinnGen only) |
243 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E22
- Name in latin
- Acromegalia
Similar endpoints
↥List of similar endpoints to
Acromegaly and pituitary gigantism
based on the number of shared cases.
Similar with more cases:
- Hyperfunction of pituitary gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1586 | 866 | 703 |
| Only index persons | 1180 | 661 | 519 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 48.81 | 49.54 | 47.84 |
| Only index persons | 45.67 | 45.99 | 45.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 243 | 150 | 93 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | 45.62 | 43.59 | 48.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 253
- Matched controls
- 2530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
298.8
224
*
H02AB09
ATC
hydrocortisone; systemic
120.1
223.8
117
18
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
1970.1
183.6
156
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
641.9
142.2
128
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
1556.1
107.6
97
*
H01CB02
ATC
octreotide; parenteral
+∞
55.3
51
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
49.6
46
*
H01CB03
ATC
lanreotide; parenteral
+∞
46.3
43
*
N04BC06
ATC
cabergoline; oral
257.7
43.4
43
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
42.9
40
*
ZXC86
NOMESCO Finland
Use of endoscopic device
152.9
37.9
39
*
2530A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]
+∞
36.3
34
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
9.7
33.1
42
51
UJF32
NOMESCO Finland
Coloscopy
4.5
31.1
118
408
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
30.9
29
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
10.8
26.4
30
31
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.5
25.5
81
240
WVA30, ,
SPAT
7.1
25.4
42
69
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
264.0
24.1
24
*
25300
ICD-8 Finland
Diseases of pituitary gland, Aeromegalia
+∞
23.3
22
*
H03AA01
ATC
levothyroxine sodium; systemic
3.8
22.6
102
384
G02CB01
ATC
bromocriptine; systemic
25.0
22.3
31
14
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
21.1
20
*
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
21.1
20
*
102
Kela drug reimbursment
Diabetes insipidus
+∞
20.1
19
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
24.0
20.0
28
13
ZXE20
NOMESCO Finland
More than three and less than five hours
4.1
18.6
62
187
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
17.0
101
439
2542
FHL
Transasal hypophysectomy
+∞
15.8
15
*
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
15.8
15
*
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
15.8
15
*
ZXC95
NOMESCO Finland
Use of surgical navigator
27.0
14.9
20
8
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
4.0
14.6
47
137
UJF30
NOMESCO Finland
Ileoscopy through colon
3.8
13.9
49
152
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
13.7
13
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
13.7
13
*
XCK00
NOMESCO Finland
Perimetry
5.0
13.5
31
69
M14.5*E22.0
ICD-10 Finland
Arthropathy associated with acromegaly
+∞
12.6
12
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
136.5
12.6
13
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.1
12.2
22
39
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.7
11.5
41
127
N04BC01
ATC
bromocriptine; oral
+∞
11.5
11
*
H01AX01
ATC
pegvisomant; parenteral
+∞
11.5
11
*
G47.3
ICD-10 Finland
Sleep apnoea
2.7
11.4
83
390
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
8.6
10.9
23
29
WX402
NOMESCO Finland
General anaesthesia
2.6
10.5
76
354
T73
ICPC
Neoplasm endocrine other/unspecified
114.6
10.5
11
*
T99
ICPC
Endocr/metab/nutrit disease other
10.7
10.2
19
19
WX882
NOMESCO Finland
High dependency care
12.9
10.0
17
14
E21.0
ICD-10 Finland
Primary hyperparathyroidism
57.2
9.7
11
*
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
22.7
9.4
13
6
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
9.4
9
*
E22
ICD-10 Finland
Hyperfunction of pituitary gland
+∞
9.4
9
*
D352, E220,
ICD-10 Finland
+∞
9.4
9
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
9.4
108
617
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.6
8.6
21
49
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
4.7
8.5
20
45
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.6
8.5
61
280
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
8.4
65
309
E23.2
ICD-10 Finland
Diabetes insipidus
+∞
8.4
8
*
-50
ICPC
Medication/prescr/renewal
4.8
8.3
19
42
WX110
NOMESCO Finland
Infiltration anesthesia
2.4
8.0
197
1497
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.9
7.8
24
67
121
Kela drug reimbursment
Severe hypofunction of sexual glands
9.3
7.7
15
17
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
7.5
51
228
E23.05
ICD-10 Finland
Lack of TSH
+∞
7.3
7
*
22620
ICD-8 Finland
Benign neoplasm of endocrine glands, Pituitary gland and craniopharyngeal duct (pouch)
+∞
7.3
7
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
7.2
67
344
N91.1
ICD-10 Finland
Secondary amenorrhoea
20.7
7.2
10
5
R06.5
ICD-10 Finland
Mouth breathing
3.0
7.1
33
120
A50
ICPC
General and Unspecified, Medication/prescr/renewal
4.4
6.7
17
41
K07.24
ICD-10 Finland
Open bite
12.7
6.6
11
9
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
6.6
58
290
M16.1
ICD-10 Finland
Other primary coxarthrosis
2.6
6.4
40
171
SPAT1254
SPAT
Administration of medicine
2.5
6.4
42
184
H01AC01
ATC
somatropin; parenteral
+∞
6.3
6
*
Y28
ICPC
Limited function/disability (Y)
+∞
6.3
6
*
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
+∞
6.3
6
*
E220, D352,
ICD-10 Finland
+∞
6.3
6
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
6.3
6
*
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
+∞
6.3
6
*
AA1AD
NOMESCO Finland
CT of head and brain
2.1
6.2
80
465
TPH07
NOMESCO Finland
Cathetrisation of artery
2.7
6.2
35
142
UDM02
NOMESCO Finland
Sinoscopy
5.8
6.1
16
29
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
6.1
81
476
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
174
220
23.13
148.78
6.5
1.9
354.78
402.52
nmol/l
2.01
166
208
66
57
15.31
67.28
2.7
1.1
7.66
7.52
u/l
0.03
53
47
31
29
12.04
29.23
2.2
1.3
0.37
0.33
nmol/l
0.08
17
23
55
116
5.78
25.97
2.4
1.3
19.33
23.83
iu/l
0.44
41
100
29
17
19.09
19.22
1.2
1.8
—
—
—
0
0
26
12
23.98
18.60
1.0
1.7
6.62
17.44
mu/l
1.76
26
12
168
974
3.16
16.86
8.5
5.6
1.22
1.21
mmol/l
1.02
158
889
178
1074
3.22
16.50
10.0
6.3
1.21
1.21
mmol/l
0.09
150
928
29
62
5.15
13.19
3.4
1.6
176.45
248.39
pmol/l
2.27
29
56
189
1300
2.79
11.67
8.3
4.4
6.45
6.63
mmol/l
0.76
181
1221
60
239
2.98
11.23
5.6
7.7
0.14
0.68
mmol/l
0.53
47
198
60
241
2.95
11.05
5.9
7.7
15.28
12.23
kpa
2.04
55
231
57
294
2.21
5.98
7.1
6.5
104.26
104.23
mmol/l
0.02
57
294
14
23
6.38
5.78
1.1
1.2
—
—
—
0
0
135
970
1.84
5.35
2.3
1.9
1.34
1.35
mmol/l
0.06
119
814
19
59
3.40
5.29
2.1
1.5
—
—
—
0
0
109
736
1.85
5.26
3.3
3.3
8.84
7.70
mmol/l
1.24
101
621
133
957
1.82
5.19
5.6
4.4
35.51
36.02
g/l
0.54
128
912
141
1034
1.82
5.16
3.1
2.6
—
—
estimate
—
0
0
14
31
4.72
4.63
2.4
2.7
5.26
7.58
pmol/l
0.87
14
31
94
631
1.78
4.47
2.5
3.2
935.03
1053.72
ng/l
0.19
84
533
40
206
2.12
4.16
3.1
3.0
—
—
—
0
0
81
540
1.74
3.85
2.5
2.2
—
—
—
0
0
199
1704
1.79
3.52
10.0
7.7
76.95
78.73
u/l
0.33
193
1602
102
752
1.60
3.19
6.0
3.0
2.36
2.35
mmol/l
0.42
96
690
155
1277
1.55
2.87
9.7
10.1
3.79
3.99
e9/l
0.51
136
1115
5
6
8.47
2.76
1.2
1.2
131.42
81.05
ug/l
—
5
6
83
603
1.56
2.69
3.8
2.9
0.73
0.34
e6/l
0.68
61
423
143
1168
1.52
2.68
7.0
6.2
10.45
11.26
umol/l
0.86
138
1107
224
2035
1.88
2.65
8.1
5.3
1.34
1.87
mu/l
12.22
214
1873
16
68
2.44
2.61
1.5
1.8
1.32
3.96
iu/l
—
5
26
7
17
4.20
2.37
2.1
2.1
1.69
3.00
nmol/l
—
7
17
225
2062
1.82
2.37
8.6
6.1
39.97
39.08
mmol/mol
0.74
220
1949
119
958
1.46
2.27
2.1
2.1
98.90
98.60
pmol/l
0.02
63
473
11
41
2.76
2.23
2.0
1.4
—
—
—
0
0
9
33
2.79
1.95
1.3
1.2
11.96
17.69
u/l
—
9
27
17
86
2.05
1.90
1.4
1.7
—
—
—
0
0
84
660
1.41
1.74
4.1
3.0
0.00
0.02
estimate
0.74
34
188
5
13
3.90
1.72
1.6
1.3
164.58
71.06
ng/l
—
5
13
24
142
1.76
1.72
1.5
1.4
—
—
—
0
0
128
1082
1.37
1.70
3.4
2.9
104.29
108.39
ug/l
0.13
117
1012
8
33
2.47
1.55
1.3
1.5
—
—
—
0
0
7
27
2.64
1.52
1.1
1.2
—
—
nmol/l
—
0
0
85
687
1.36
1.46
4.0
3.8
0.00
0.00
estimate
0.50
40
217
12
60
2.05
1.40
1.4
1.2
—
—
—
0
0
46
337
1.45
1.39
3.4
2.8
1.82
2.97
e6/l
0.62
23
153
184
1674
1.36
1.39
4.7
4.3
12.39
11.06
mm/h
0.63
176
1552
5
17
2.98
1.36
1.0
1.4
83.20
97.53
pmol/l
—
5
17
52
397
1.39
1.26
5.1
3.9
48.20
383.17
ng/l
1.98
35
296
5
19
2.66
1.22
1.0
1.1
—
—
—
0
0
5
19
2.66
1.22
2.0
2.1
2.20
3.44
u/field
—
5
9
5
19
2.66
1.22
1.0
1.1
—
—
—
0
0
32
233
1.43
1.02
2.3
5.2
239.41
244.30
u/l
0.07
32
226
135
1209
1.25
0.98
4.1
3.7
0.00
0.00
estimate
-0.00
43
236
136
1220
1.25
0.97
4.3
3.7
0.00
0.00
estimate
-0.00
41
219
65
534
1.29
0.97
2.2
2.1
2.94
3.07
mg/l
0.18
58
463
105
921
1.24
0.90
4.2
3.6
0.06
0.02
estimate
0.32
35
197
133
1197
1.23
0.90
4.2
3.7
0.00
0.00
estimate
0.50
41
234
53
428
1.30
0.90
3.4
2.7
2.45
2.44
mmol/l
0.31
47
386
143
1559
0.81
0.89
3.8
3.2
42.01
46.88
u/l
0.45
137
1469
6
30
2.02
0.87
1.2
1.3
—
—
—
0
0
83
712
1.25
0.87
2.7
2.5
61.78
61.39
u/l
0.01
76
655
10
58
1.75
0.81
1.1
1.9
—
—
—
0
0
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
0
26
0.00
0.79
0.0
2.8
—
—
—
0
0
97
855
1.22
0.78
3.9
3.5
34.26
34.44
ng/l
0.00
75
578
44
537
0.78
0.75
3.8
3.6
1.02
1.02
kg/l
0.49
30
352
73
628
1.23
0.74
1.8
1.7
19.71
20.77
nmol/l
0.23
60
531
7
41
1.73
0.70
1.0
1.3
0.43
0.86
nmol/l
—
7
35
20
271
0.72
0.70
1.9
2.1
—
—
—
0
0
30
379
0.76
0.67
1.7
1.5
—
—
—
0
0
45
371
1.26
0.66
3.4
2.6
2.60
0.99
e6/l
0.39
23
184
5
29
1.74
0.64
1.2
1.0
—
—
—
0
0
5
30
1.68
0.61
1.4
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.9
—
—
—
0
0
16
114
1.43
0.60
7.7
2.7
24.71
24.41
mmol/l
0.18
16
114
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
4.4
—
70.12
—
0
22
7
114
0.60
0.59
1.0
1.3
—
—
—
0
0
8
55
1.47
0.56
2.3
1.2
—
—
—
0
0
8
124
0.63
0.56
1.1
2.2
—
—
—
0
0
6
37
1.64
0.56
1.2
1.2
—
—
—
0
0
62
542
1.19
0.53
1.5
1.3
1.57
1.54
u/ml
0.01
16
146
10
144
0.68
0.50
1.3
2.2
—
—
—
0
0
78
700
1.17
0.50
4.8
4.2
6.39
9.74
mg/mmol
0.52
59
440
41
347
1.22
0.50
1.8
1.8
—
—
—
0
0
7
109
0.63
0.49
2.4
2.5
36.86
42.11
u/l
—
7
98
7
45
1.57
0.49
1.4
1.4
—
—
—
0
0
25
201
1.27
0.47
2.2
2.5
0.20
0.22
g/l
0.79
25
187
20
250
0.78
0.43
1.9
2.0
—
—
—
0
0
20
158
1.29
0.43
1.3
1.3
135.25
144.86
u/ml
—
8
65
20
248
0.79
0.41
7.6
6.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
58
518
1.16
0.39
1.9
1.7
1.24
1.16
mg/l
0.07
49
394
14
107
1.33
0.38
1.5
1.3
—
—
—
0
0
9
69
1.32
0.37
5.4
2.1
24.29
24.85
mmol/l
—
9
69
5
37
1.36
0.37
1.4
1.6
—
—
—
0
0
214
2095
1.14
0.28
23.3
13.9
84.59
82.99
ml/min/173m2
0.56
209
1930
20
169
1.20
0.26
2.4
2.6
84.89
68.85
ml/min/173m2
—
9
73
9
72
1.26
0.26
1.3
1.3
—
—
—
0
0
223
2191
1.15
0.26
20.9
14.3
25.01
22.63
mg/l
0.52
186
1762
180
1849
0.91
0.25
29.4
18.4
331.56
332.34
g/l
0.59
180
1841
10
126
0.79
0.25
1.0
1.1
—
—
—
0
0
7
94
0.74
0.23
1.6
1.1
1.44
1.56
g/l
—
7
94
7
95
0.73
0.22
1.6
1.1
0.90
0.91
g/l
—
7
95
38
345
1.12
0.22
1.6
1.6
1086.94
1185.98
nmol/l
0.27
31
251
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
43
468
0.90
0.21
1.2
1.3
39.60
34.80
iu/ml
—
10
153
10
80
1.26
0.21
1.5
1.5
—
—
—
0
0
28
250
1.13
0.20
1.8
1.8
—
—
—
0
0
40
435
0.90
0.19
1.4
1.7
465.64
31367755.13
pmol/l
0.50
33
373
10
122
0.81
0.19
1.6
1.7
—
—
—
0
0
29
262
1.12
0.18
1.7
1.7
—
—
—
0
0
7
60
1.17
0.18
1.3
1.1
—
2.59
—
0
11
7
60
1.17
0.18
1.3
1.6
—
—
—
0
0
7
60
1.17
0.18
1.4
1.6
—
—
—
0
0
34
370
0.91
0.17
2.6
2.8
0.53
0.74
ug/l
2.32
23
217
5
67
0.74
0.17
2.0
2.2
—
—
—
0
0
8
68
1.18
0.17
2.5
1.8
—
—
—
0
0
8
73
1.10
0.16
2.5
2.1
—
—
—
0
0
6
80
0.74
0.15
1.7
1.9
—
—
—
0
0
239
2371
1.14
0.13
33.3
22.2
91.12
91.02
fl
0.13
239
2345
239
2372
1.14
0.12
34.1
22.6
40.19
40.56
%
0.57
239
2344
13
147
0.88
0.12
1.2
1.3
158.23
459.39
u/ml
0.85
13
137
239
2374
1.12
0.10
33.7
22.4
133.66
135.87
g/l
1.52
239
2347
5
62
0.80
0.08
1.0
1.1
—
—
—
0
0
5
64
0.78
0.08
1.2
1.3
—
—
—
0
0
6
71
0.84
0.07
1.2
1.3
—
—
—
0
0
139
1408
0.97
0.06
2.9
3.2
—
—
—
0
0
45
436
1.04
0.05
1.2
1.3
1.22
9.02
u/ml
2.90
22
176
13
122
1.07
0.02
5.8
2.4
0.58
0.63
%
0.32
13
122
47
480
0.97
0.02
4.2
4.2
23.30
22.26
%
0.17
22
207
19
182
1.05
0.02
1.8
2.4
0.24
0.19
e6/l
0.17
19
171
13
123
1.06
0.01
5.8
2.5
0.92
1.31
%
1.27
13
123
18
187
0.96
0.01
1.4
1.4
—
—
—
0
0
43
428
1.01
0.00
1.6
1.6
—
—
—
0
0
28
279
1.00
0.00
4.6
4.9
32.18
31.87
%
0.04
22
175
7
79
0.88
0.00
1.3
1.3
—
3.32
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.3
1.3
—
47.03
—
0
11
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
7
76
0.92
-0.00
1.3
1.4
—
2.83
—
0
17
0
7
0.00
-0.00
0.0
1.0
—
0.23
—
0
7
7
70
1.00
-0.00
1.3
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.8
—
4.62
—
0
8
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
0.30
—
0
8
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
76
0.92
-0.00
1.3
1.4
—
2.58
—
0
13
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.8
—
10.20
—
0
8
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_ACROMEG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ACROMEG | 1.68 [1.25, 2.25] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.335 |
During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 432 females with E4_ACROMEG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ACROMEG | 1.62 [1.24, 2.12] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 350 males with E4_ACROMEG died.
Mortality risk
Mortality risk for people of age
years, who have E4_ACROMEG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.274% |
| 5 | 0.885% | 2.148% |
| 10 | 2.427% | 5.483% |
| 15 | 4.67% | 9.864% |
| 20 | 8.7% | 16.301% |
Relationships between endpoints
↥Index endpoint: E4_ACROMEG – Acromegaly and pituitary gigantism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data