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Other nonthrombocytopenic purpura

DOID EFO Endpoint Browser PheWeb

D3_OTHNONTHROMBOCYTOPENPURPURA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D69.2
  • Hospital discharge: ICD-9 — 2872
  • Cause of death: ICD-10 — D69.2
  • Cause of death: ICD-9 — 2872

2 out of 7 registries used, show all original rules.

399

4. Check minimum number of events

None

399

5. Include endpoints

None

399

6. Filter based on genotype QC (FinnGen only)

353

Control definitions (FinnGen only)

Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D69
Name in latin
Purpura non thrombocytopenica

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2281 1241 1022
Only index persons 1995 1125 870
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.03
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 61.62 63.49 59.23
Only index persons 59.44 61.58 56.67

-FinnGen-

Key figures

All Female Male
Number of individuals 353 208 145
Unadjusted period prevalence (%) 0.07 0.07 0.07
Median age at first event (years) 61.40 59.99 63.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
364
Matched controls
3640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
16384.0
307.7
347
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.5
63.2
112
204
D69.0
ICD-10 Finland
Allergic purpura
508.3
46.4
45
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.1
34.8
137
471
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
104.8
27.1
29
*
D07AC01
ATC
betamethasone; topical
3.0
23.5
187
948
H02AB06
ATC
prednisolone; systemic
3.0
22.5
228
1308
E0000UV, ,
ATC
2.8
21.1
202
1113
L04AX01
ATC
azathioprine; systemic
6.7
20.1
33
53
2872B
ICD-9 Finland
Purpura and other haemorrhagic conditions, Other nonthrombocytopenic purpuras
+∞
18.9
18
*
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
17.9
17
*
R23.3
ICD-10 Finland
Spontaneous ecchymoses
7.4
16.7
25
36
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
29.1
16.7
22
8
D07AB08
ATC
desonide; topical
3.4
16.2
66
222
D07AD01
ATC
clobetasol; topical
2.8
14.8
88
368
S29
ICPC
Skin symptom/complaint other
2.6
14.7
107
496
L81.7
ICD-10 Finland
Pigmented purpuric dermatosis
31.4
14.0
18
6
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.5
13.8
35
84
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
13.3
71
279
WW200
NOMESCO Finland
Immunization
6.2
13.2
23
39
D07AB02
ATC
hydrocortisone butyrate; topical
2.3
12.8
132
712
R50.9
ICD-10 Finland
Fever, unspecified
2.7
12.5
79
339
A46
ICD-10 Finland
Erysipelas
2.7
12.4
81
353
C03CA01
ATC
furosemide; systemic
2.2
11.5
142
819
R60.0
ICD-10 Finland
Localized oedema
2.6
10.8
71
309
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
10.7
203
1368
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.3
10.6
28
69
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
10.5
10
*
XW000
NOMESCO Finland
Bone marrow biopsy
4.2
10.2
28
71
D07AC13
ATC
mometasone; topical
2.2
10.1
122
691
R60.9
ICD-10 Finland
Oedema, unspecified
3.5
9.9
36
112
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.6
9.8
62
264
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
9.6
152
948
S16
ICPC
Bruise/contusion
4.7
9.4
22
49
L04AX03
ATC
methotrexate; systemic
2.8
9.2
49
191
L17
ICPC
Foot/toe symptom/complaint
2.0
9.2
137
835
L95.8
ICD-10 Finland
Other vasculitis limited to skin
37.7
9.1
11
*
B01AA03
ATC
warfarin; systemic
2.2
8.5
82
422
D07BC01
ATC
betamethasone and antiseptics; topical
2.5
8.0
52
224
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.5
8.0
53
231
E000001, ,
ATC
2.2
7.9
81
426
C08CA13
ATC
lercanidipine; oral
2.2
7.8
72
362
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
15.5
7.8
12
8
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
46.0
7.7
9
*
ZX120
NOMESCO Finland
Intravenous
2.6
7.7
46
190
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
7.7
53
235
P01BA02
ATC
hydroxychloroquine; oral
2.8
7.7
41
160
A02BC02
ATC
pantoprazole; systemic
2.0
7.6
261
2052
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
7.6
54
243
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.0
7.4
33
116
R06AE07
ATC
cetirizine; oral
1.8
7.4
166
1140
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
7.3
93
529
S97
ICPC
Chronic ulcer skin
2.8
7.3
38
146
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
7.0
79
429
QDB10, ,
SPAT
4.0
6.8
19
49
S21
ICPC
Skin texture symptom/complaint
2.1
6.8
70
368
C03DA01
ATC
spironolactone; oral
2.2
6.6
57
279
D05AX02
ATC
calcipotriol; topical
3.8
6.6
20
55
K07
ICPC
Swollen ankles/oedema
3.1
6.5
27
91
M13.9
ICD-10 Finland
Arthritis, unspecified
2.7
6.4
36
144
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.9
6.4
91
536
J01FF01
ATC
clindamycin; systemic
1.9
6.4
105
649
L30.8
ICD-10 Finland
Other specified dermatitis
4.0
6.3
18
47
205
Kela drug reimbursment
Chronic hypertension
1.9
6.3
107
667
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
6.3
6
*
XQ848
NOMESCO Finland
Dermatological photography
3.7
6.2
20
57
S01
ICPC
Pain/tenderness of skin
3.1
6.2
26
88
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
6.2
49
231
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.2
6.1
52
252
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.5
6.1
41
179
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
6.1
60
309

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
86
133
8.16
55.90
2.2
1.5
13.48
12.08
iu/ml
—
6
5
78
116
8.29
52.29
1.7
1.3
—
—
—
0
0
85
146
7.29
49.95
1.3
1.3
—
—
—
0
0
64
140
5.33
28.58
1.5
1.7
11.37
5.62
iu/ml
0.55
16
36
123
455
3.57
27.14
1.5
1.4
701.33
426.80
titre
0.60
30
103
87
267
3.97
25.15
2.2
2.7
66.01
66.07
g/l
0.02
79
246
270
1688
3.32
23.09
10.4
6.0
0.60
0.57
e9/l
0.88
245
1441
270
1696
3.29
22.74
10.5
6.0
0.04
0.04
e9/l
0.16
245
1450
76
227
3.97
22.67
2.1
2.3
—
—
—
0
0
272
1745
3.21
21.48
10.6
6.3
0.19
0.19
e9/l
0.32
248
1523
270
1731
3.17
21.22
10.6
6.0
1.84
1.88
e9/l
0.19
249
1531
283
1884
3.26
20.40
13.5
9.5
4.37
4.13
e9/l
0.95
256
1659
67
221
3.49
17.02
2.3
1.4
0.99
1.21
g/l
1.18
62
201
231
1472
2.56
16.41
7.0
4.7
34.80
35.76
g/l
1.71
221
1385
238
1549
2.55
15.98
10.9
6.3
8.80
8.86
%
0.12
230
1457
184
1077
2.43
15.44
9.9
6.0
—
—
—
0
0
236
1547
2.49
15.33
11.0
6.2
0.66
0.66
%
0.01
227
1448
236
1549
2.49
15.26
10.9
6.2
2.83
2.86
%
0.10
228
1455
237
1580
2.43
14.47
11.0
6.2
25.95
27.37
%
1.11
228
1499
94
435
2.57
12.77
9.0
5.7
1.08
1.05
mmol/l
0.47
87
401
38
103
4.00
12.74
2.2
3.7
45.41
31.89
mg/l
0.97
29
90
38
103
4.00
12.74
2.2
3.7
108.04
109.18
mg/l
0.01
29
90
41
118
3.79
12.64
2.0
2.1
11.07
9.85
g/l
0.66
36
104
242
1690
2.29
12.37
9.5
7.2
1.21
1.21
mmol/l
0.46
219
1459
35
94
4.01
11.87
2.3
3.4
8.60
2.51
ratio
0.38
20
56
104
523
2.38
11.70
3.6
2.5
2.43
2.28
g/l
1.63
98
480
153
922
2.14
10.96
6.3
4.2
—
—
—
0
0
134
770
2.17
10.82
4.2
2.8
3.46
6.46
e6/l
1.94
125
705
29
73
4.23
10.71
1.6
1.7
—
—
—
0
0
146
872
2.13
10.64
3.1
2.2
2.93
2.98
mg/l
0.10
134
748
169
1069
2.08
10.55
6.7
3.9
7.40
7.40
ph
0.23
130
762
217
1528
2.04
9.85
8.5
6.8
1.21
1.21
mmol/l
0.63
205
1402
211
1476
2.02
9.70
17.9
11.6
0.00
0.00
e9/l
0.61
172
1213
241
1782
2.04
9.31
8.3
6.4
11.09
11.14
umol/l
0.03
232
1699
103
565
2.15
9.14
3.9
2.5
11.88
12.76
umol/l
0.46
98
520
169
1114
1.97
9.00
5.6
3.5
63.87
104.75
e6/l
0.26
141
859
76
372
2.32
8.88
1.9
1.5
—
—
—
0
0
151
962
1.97
8.84
5.3
3.2
0.35
0.43
e6/l
0.26
121
713
77
380
2.30
8.82
2.5
1.7
—
—
—
0
0
107
603
2.10
8.81
1.6
1.3
69.22
31.32
iu/ml
0.50
32
204
22
52
4.44
8.78
2.4
1.3
0.86
0.70
g/l
0.34
17
45
255
1948
2.03
8.68
6.1
5.4
6.59
6.67
mmol/l
0.32
249
1837
279
2203
2.14
8.67
7.5
4.7
—
3.08
—
0
7
127
769
2.00
8.55
7.1
4.8
—
—
—
0
0
137
852
1.97
8.54
3.7
2.9
354.23
343.57
umol/l
0.47
126
749
118
701
2.01
8.35
2.0
1.4
2.81
2.52
g/l
0.68
88
419
89
477
2.15
8.30
3.3
2.0
—
—
—
0
0
302
2490
2.25
7.94
13.6
8.0
84.09
78.03
u/l
1.54
294
2354
18
27
6.96
7.69
1.7
1.3
0.47
0.45
g/l
0.06
13
22
59
275
2.37
7.65
5.6
4.6
0.20
0.68
%
2.26
25
84
151
999
1.87
7.63
8.7
6.2
—
—
—
0
0
68
339
2.24
7.54
2.8
2.0
339.25
384.15
nmol/l
0.90
63
318
76
397
2.16
7.51
3.8
2.5
1.96
1.82
%
0.78
69
357
212
1567
1.85
7.44
21.3
12.9
1.36
1.23
inr
2.40
177
1296
139
907
1.86
7.25
5.2
3.1
—
0.00
estimate
—
0
5
38
147
2.77
7.21
1.6
1.7
1.54
1.50
g/l
0.11
32
131
19
47
4.21
7.17
2.1
1.3
—
—
—
0
0
156
1061
1.82
7.08
2.1
2.2
155.72
209.11
u/l
0.61
151
1009
156
1063
1.82
7.03
4.8
3.4
—
—
—
0
0
159
1093
1.81
6.93
5.7
4.0
16.85
11.00
mg/mmol
0.52
122
674
58
280
2.27
6.92
5.9
4.8
0.09
0.16
%
0.41
22
79
61
302
2.23
6.85
4.1
2.5
73.70
70.43
e9/l
0.32
42
235
17
28
6.31
6.85
1.9
1.3
—
—
—
0
0
194
1419
1.79
6.82
5.6
3.8
6.41
6.23
ph
1.24
107
788
124
797
1.84
6.69
6.3
4.2
—
0.30
—
0
10
70
370
2.10
6.67
7.2
3.8
7.38
7.38
ph
0.10
45
223
93
545
1.95
6.66
1.5
1.3
8.77
11.64
u/ml
0.20
34
212
98
587
1.92
6.57
2.3
1.8
—
—
—
0
0
60
301
2.19
6.52
5.8
4.7
0.48
0.99
%
1.96
25
100
26
86
3.18
6.48
4.6
3.2
2.53
2.71
index
0.04
17
51
202
1514
1.75
6.36
4.4
3.0
119.22
119.27
ug/l
0.00
195
1401
20
57
3.65
6.25
1.6
1.4
—
—
—
0
0
20
57
3.65
6.25
1.5
1.4
—
—
—
0
0
228
1778
1.76
6.16
6.3
4.4
28.93
4.11
estimate
0.40
55
395
174
1260
1.73
6.12
6.9
4.1
38.94
93.37
e6/l
1.36
139
900
62
323
2.11
6.11
6.8
9.3
—
—
—
0
0
226
1768
1.73
5.94
6.3
4.3
0.00
0.00
estimate
-0.00
55
383
106
674
1.81
5.80
4.3
3.2
481.44
525.67
mosm/kgh2o
1.64
95
587
103
651
1.81
5.74
5.5
4.2
126.35
328.42
ng/l
1.48
91
518
228
1798
1.72
5.72
6.4
4.3
0.00
0.82
estimate
0.50
52
371
44
205
2.30
5.69
5.5
2.8
0.78
0.63
%
0.79
44
205
49
239
2.21
5.69
1.7
1.4
—
—
—
0
0
157
1125
1.70
5.60
5.3
3.2
6.77
7.61
mmol/l
1.54
141
946
150
1063
1.70
5.57
4.9
3.4
97.63
64.28
mg/l
0.57
116
689
83
497
1.87
5.48
2.0
1.6
—
—
—
0
0
56
294
2.07
5.39
7.1
5.2
0.00
0.18
%
0.91
20
77
31
126
2.60
5.37
1.5
2.5
19.48
21.42
s
1.59
23
116
19
59
3.34
5.25
1.3
1.4
311.40
257.09
u/ml
—
10
33
148
1067
1.65
5.02
3.0
2.5
61.58
64.99
u/l
0.16
140
994
90
568
1.78
4.97
2.0
1.7
1124.13
1254.38
nmol/l
0.76
71
425
150
1088
1.64
4.96
4.5
3.5
1851.91
1361.30
ng/l
0.67
136
924
17
51
3.45
4.95
1.2
1.2
3.29
4.33
u/ml
—
7
18
65
373
1.90
4.86
3.1
2.9
8.46
6.12
umol/l
0.43
59
326
106
707
1.70
4.80
3.3
2.8
2.46
2.46
mmol/l
0.33
97
638
110
746
1.68
4.67
1.9
1.9
1.63
1.32
mg/l
0.34
88
597
139
1001
1.63
4.66
1.8
1.7
21.04
20.91
nmol/l
0.03
122
833
70
421
1.82
4.51
1.5
1.5
—
—
—
0
0
145
1062
1.61
4.51
3.8
3.2
34.40
31.53
u/l
0.55
135
1011
337
3070
2.32
4.44
33.1
16.4
24.34
23.31
mg/l
0.26
304
2536
171
1309
1.58
4.37
5.0
4.3
49.06
34.00
ng/l
0.51
135
974
189
1483
1.57
4.33
2.4
2.1
92.01
95.48
pmol/l
0.47
113
745
15
39
3.97
4.24
2.1
2.1
—
—
—
0
0
9
13
7.07
4.18
1.3
1.2
502.80
129.12
iu/ml
—
9
13
20
74
2.80
4.16
2.3
1.4
15652.00
20862.84
e6/l
0.20
15
56
14
42
3.43
4.08
1.1
1.3
—
—
—
0
0
136
1001
1.57
4.05
6.9
4.6
0.00
0.01
estimate
0.50
50
363
21
81
2.69
4.05
1.6
1.2
—
—
—
0
0
186
1480
1.53
3.83
3.2
2.5
78.30
77.36
nmol/l
0.17
173
1317
22
91
2.51
3.71
1.3
1.4
—
—
—
0
0
10
20
5.11
3.71
1.0
1.1
—
—
—
0
0
14
46
3.13
3.57
1.8
1.4
32.39
33.74
g/l
0.14
14
41
13
36
3.71
3.53
1.4
2.6
—
—
—
0
0
150
1156
1.51
3.51
3.8
3.3
2.36
2.36
mmol/l
0.19
142
1040
276
2416
1.59
3.50
4.9
4.4
14.71
14.90
pmol/l
0.61
261
2185
20
83
2.49
3.36
2.4
1.9
131.62
128.87
g/l
0.23
13
63
259
2247
1.53
3.31
5.3
4.3
—
0.00
—
0
5
11
29
3.88
3.21
1.1
1.2
—
—
—
0
0
8
15
5.43
3.21
1.1
1.4
—
—
—
0
0
11
30
3.75
3.11
1.1
1.0
—
—
—
0
0
315
2874
1.71
3.10
6.3
5.4
1.86
1.92
mu/l
0.51
301
2632
53
328
1.72
3.09
2.7
2.1
0.00
0.00
estimate
-0.00
13
79
75
509
1.60
3.07
6.4
6.6
103.27
104.23
mmol/l
1.20
75
509
8
16
5.09
3.06
2.5
1.8
113.79
71.09
ng/l
—
8
16
80
552
1.58
3.05
4.8
3.1
3.19
2.62
e6/l
0.17
44
281
50
306
1.73
3.03
2.8
2.5
28.67
30.04
u/l
0.19
42
252
21
94
2.31
3.02
1.6
1.4
269.77
304.39
ug/g
0.34
13
55
67
444
1.62
3.02
1.1
1.2
—
—
—
0
0
5
5
10.11
2.98
1.0
1.2
—
—
—
0
0
5
5
10.11
2.98
1.2
2.6
28.00
19.20
%
—
5
5
13
46
2.89
2.95
1.2
1.0
—
—
—
0
0
37
209
1.86
2.92
6.0
2.8
1.16
1.25
%
0.29
37
209
137
1069
1.45
2.89
3.1
2.4
—
—
—
0
0
50
311
1.70
2.86
1.9
1.5
—
—
—
0
0
104
770
1.49
2.86
6.5
4.7
1.02
1.02
kg/l
0.18
75
519
162
1307
1.43
2.84
2.8
2.1
—
—
—
0
0
21
97
2.24
2.83
1.4
1.5
259.10
316.90
mu/l
0.74
21
92
238
2066
1.44
2.74
4.0
3.3
65.95
46.35
u/l
2.23
227
1939
47
291
1.71
2.74
3.3
2.8
6.02
7.13
ug/l
0.16
42
254
60
403
1.59
2.56
4.3
9.5
0.94
0.98
mmol/l
0.03
55
340
6
11
5.52
2.55
2.5
3.7
861.67
525.82
u/ml
—
6
11
64
437
1.56
2.54
3.1
2.4
216.64
125.37
ug/g
0.49
53
348
10
31
3.29
2.53
1.4
1.1
—
—
—
0
0
11
37
3.03
2.51
1.5
1.3
—
—
—
0
0
39
237
1.72
2.44
5.0
3.0
128.31
128.64
g/l
0.04
39
230
19
90
2.17
2.43
3.5
3.1
7.72
8.22
kpa
0.97
19
90
9
27
3.39
2.41
1.0
1.2
—
—
—
0
0
286
2597
1.47
2.38
36.5
20.5
14.15
13.67
%
6.01
281
2572
12
46
2.66
2.38
1.3
1.1
—
—
—
0
0
10
33
3.09
2.37
1.1
1.1
—
—
—
0
0
163
1348
1.38
2.36
6.1
4.4
0.00
0.04
estimate
1.64
42
321
15
65
2.36
2.34
4.7
3.2
—
—
—
0
0
35
209
1.75
2.33
2.4
7.0
—
—
—
0
0
100
763
1.43
2.31
1.4
1.3
1.32
1.37
u/ml
0.03
30
211
334
3145
1.75
2.30
36.3
19.9
3.96
3.98
mmol/l
1.07
329
3073
6
13
4.67
2.28
1.2
1.0
—
—
—
0
0
180
1521
1.36
2.24
3.3
2.8
—
—
estimate
—
0
0
9
29
3.16
2.24
1.3
1.3
—
—
—
0
0
9
29
3.16
2.24
2.6
3.9
881.67
1022.21
mg
—
9
29
11
43
2.61
2.10
1.2
1.0
—
—
—
0
0
10
37
2.75
2.08
1.6
1.2
—
—
—
0
0
5
10
5.05
2.07
1.0
1.1
—
—
—
0
0
21
111
1.95
2.05
3.7
2.5
24.69
24.65
mmol/l
0.02
21
111
11
44
2.55
2.03
3.3
1.5
32.91
33.14
pg
0.05
11
44
9
32
2.86
2.01
1.6
1.1
—
—
—
0
0
58
409
1.50
2.00
4.5
9.4
7.41
7.41
ph
0.11
31
241
58
409
1.50
2.00
4.5
9.3
11.14
12.08
kpa
0.71
58
393
58
409
1.50
2.00
4.5
9.3
5.15
5.15
kpa
0.00
58
393
340
3238
1.76
1.95
40.3
21.7
85.28
77.61
umol/l
2.06
334
3199
339
3226
1.74
1.95
20.7
12.2
27.00
25.36
u/l
0.92
334
3138
317
2976
1.50
1.86
6.1
5.3
6.03
5.98
mmol/l
0.32
301
2713
6
18
3.37
1.75
1.0
1.1
—
—
—
0
0
20
111
1.85
1.72
3.5
3.6
159.70
190.59
mg/l
—
10
41
5
13
3.88
1.72
1.0
1.1
—
—
—
0
0
5
14
3.61
1.62
1.0
1.2
104.80
157.55
mmol/24h
—
5
14
39
265
1.53
1.62
6.4
4.3
—
—
—
0
0
20
114
1.80
1.60
1.5
1.2
—
—
—
0
0
11
50
2.24
1.58
2.9
1.8
0.80
0.95
%
—
6
34
19
107
1.82
1.58
13.3
11.1
—
—
—
0
0
14
252
0.54
1.49
1.2
1.4
—
—
—
0
0
37
255
1.50
1.45
1.2
1.2
—
—
—
0
0
329
3143
1.49
1.43
24.4
14.6
—
—
—
0
0
11
53
2.11
1.40
4.9
3.1
4.16
4.37
e9/l
0.17
11
53
309
2924
1.38
1.38
8.3
6.6
40.97
39.50
mmol/mol
1.88
293
2746
9
41
2.22
1.38
1.0
1.1
—
15.25
—
0
14
6
24
2.52
1.31
2.2
2.0
39.25
35.48
%
—
6
24
8
35
2.31
1.27
1.8
1.2
—
—
—
0
0
85
693
1.30
1.25
1.8
1.8
464.32
20490819.67
pmol/l
0.50
72
571
13
70
1.89
1.25
1.3
1.5
492.38
471.05
mg/l
0.10
13
65
6
25
2.42
1.25
1.2
2.7
0.83
0.88
index
—
6
25
29
197
1.51
1.24
1.6
1.3
—
—
—
0
0
40
291
1.42
1.22
1.9
1.5
—
—
—
0
0
5
19
2.65
1.22
1.0
1.8
—
—
—
0
0
47
353
1.38
1.20
3.9
9.5
117.70
121.13
g/l
0.60
47
345
0
34
0.00
1.16
0.0
1.6
—
7.56
—
0
34
25
169
1.51
1.10
3.0
2.2
0.00
0.00
estimate
—
10
65
7
32
2.21
1.08
1.1
2.3
10.11
11.62
%
—
7
32
13
74
1.78
1.08
2.6
2.8
95.99
87.74
ug/min
—
7
47
18
114
1.61
1.04
1.2
1.1
—
—
—
0
0
13
75
1.76
1.04
4.3
2.8
58.92
58.95
%
0.00
13
75
19
123
1.57
1.02
1.8
2.7
—
—
—
0
0
15
92
1.66
0.98
1.3
1.3
146.43
255.49
miu/ml
—
7
47
319
3067
1.32
0.98
6.8
6.0
2.44
2.65
mmol/l
4.62
300
2835
55
439
1.30
0.96
1.5
1.3
—
—
—
0
0
24
168
1.46
0.92
1.2
1.1
—
—
—
0
0
6
28
2.16
0.92
1.0
1.1
—
—
—
0
0
6
28
2.16
0.92
1.0
1.0
—
—
—
0
0
8
44
1.84
0.86
2.5
1.1
—
—
—
0
0
12
72
1.69
0.86
1.1
1.3
51.92
60.30
mmol/l
0.45
12
66
146
1313
1.19
0.85
2.2
2.0
1.29
1.35
mmol/l
0.51
124
1084
6
31
1.95
0.84
1.0
1.1
—
—
—
0
0
8
47
1.72
0.81
1.1
1.4
—
—
—
0
0
8
47
1.72
0.81
1.1
1.4
—
—
—
0
0
8
47
1.72
0.81
1.1
1.4
—
—
—
0
0
8
47
1.72
0.81
1.1
1.4
—
—
—
0
0
8
47
1.72
0.81
1.0
1.8
—
—
—
0
0
36
279
1.32
0.79
6.4
4.0
7.40
7.36
ph
1.86
29
193
0
26
0.00
0.78
0.0
1.6
—
16.48
—
0
26
11
67
1.66
0.76
2.8
3.0
8.98
7.88
pmol/l
0.23
11
67
5
24
2.10
0.75
1.0
1.0
—
—
—
0
0
7
38
1.86
0.74
1.1
1.5
28.07
34.56
ng/l
—
7
38
26
194
1.37
0.73
4.2
12.4
15.49
15.61
%
0.09
26
184
5
25
2.01
0.73
1.0
1.3
—
—
—
0
0
32
248
1.32
0.72
2.9
2.2
9.32
13.40
nmol/l
2.18
26
230
20
143
1.42
0.71
4.0
3.5
—
—
—
0
0
48
393
1.26
0.71
1.6
1.3
—
—
—
0
0
11
69
1.61
0.69
2.2
2.6
55.15
32.95
umol/l
0.48
11
60
106
945
1.17
0.67
4.3
3.1
—
0.09
—
0
23
6
35
1.73
0.58
2.0
1.5
—
—
—
0
0
14
98
1.45
0.57
1.4
1.1
—
—
—
0
0
16
215
0.73
0.54
1.6
1.7
3.13
3.44
mmol/l
—
8
161
309
3009
1.18
0.50
6.1
5.3
4.32
4.57
mmol/l
5.01
295
2790
308
3000
1.17
0.49
5.9
5.1
1.45
1.48
mmol/l
0.61
291
2765
35
292
1.22
0.47
2.1
1.7
—
—
—
0
0
19
147
1.31
0.46
1.3
1.3
0.35
0.30
mg/l
—
8
59
20
156
1.30
0.46
2.1
1.9
—
—
—
0
0
5
31
1.62
0.43
1.0
1.2
101.20
107.03
pmol/l
—
5
31
42
361
1.18
0.43
3.5
4.4
3.64
35.89
ug/l
0.86
32
305
22
176
1.27
0.43
2.6
2.6
—
—
—
0
0
104
958
1.12
0.41
5.6
5.7
2.23
2.65
ug/l
0.39
96
845
0
15
0.00
0.41
0.0
1.0
—
15.54
—
0
5
0
15
0.00
0.41
0.0
1.0
—
0.32
—
0
6
0
16
0.00
0.41
0.0
1.4
—
7.30
—
0
16
0
16
0.00
0.41
0.0
1.1
—
0.18
—
0
10
294
2870
1.13
0.37
5.1
4.4
1.29
1.26
mmol/l
0.31
275
2621
6
41
1.47
0.36
3.2
3.3
—
—
—
0
0
28
236
1.20
0.36
5.4
8.4
24.81
24.46
mmol/l
0.21
28
224
105
984
1.09
0.30
4.7
3.7
0.00
0.08
estimate
0.50
39
311
7
54
1.30
0.30
1.1
1.1
—
—
—
0
0
7
54
1.30
0.30
1.1
1.1
—
—
—
0
0
7
54
1.30
0.30
1.3
1.2
—
—
—
0
0
63
578
1.11
0.28
3.3
3.3
0.86
0.74
ug/l
0.25
45
380
5
71
0.70
0.26
3.8
3.7
17.00
29.44
u/ml
—
5
71
18
153
1.19
0.23
1.2
1.1
—
—
—
0
0
5
42
1.19
0.21
8.2
3.0
4.12
4.03
mmol/l
—
5
42
5
42
1.19
0.21
8.2
3.0
1.19
1.20
mmol/l
—
5
42
5
42
1.19
0.21
8.2
3.0
104.40
105.93
mmol/l
—
5
42
6
48
1.25
0.20
2.7
2.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
0.47
—
0
9
31
284
1.10
0.15
1.4
1.5
—
—
—
0
0
7
87
0.80
0.14
1.1
1.1
—
—
—
0
0
112
1153
0.96
0.11
3.4
3.3
—
—
—
0
0
34
361
0.94
0.10
1.5
1.7
—
—
—
0
0
6
56
1.07
0.08
1.3
1.3
—
—
—
0
0
19
205
0.92
0.08
1.4
1.3
—
—
—
0
0
7
67
1.05
0.08
17.0
1.5
—
—
—
0
0
8
74
1.08
0.07
3.0
2.1
—
—
—
0
0
9
87
1.04
0.07
1.2
1.1
0.85
0.91
g/l
—
9
87
9
88
1.02
0.07
1.6
1.4
—
—
—
0
0
8
92
0.87
0.07
1.3
1.4
—
—
—
0
0
8
94
0.85
0.07
8.0
4.6
—
—
—
0
0
95
934
1.02
0.04
1.5
1.4
—
—
—
0
0
10
109
0.92
0.04
1.6
1.4
—
—
—
0
0
10
108
0.92
0.03
1.6
1.4
—
—
—
0
0
13
123
1.06
0.01
1.1
1.8
—
—
—
0
0
27
276
0.98
0.00
3.3
2.9
5.89
6.09
ph
0.57
19
192
10
98
1.02
0.00
2.2
1.7
42.00
41.87
nmol/l
—
10
93
10
102
0.98
0.00
1.6
1.4
—
—
—
0
0
22
219
1.00
0.00
1.5
1.2
99.89
151.73
u/ml
—
9
82
11
106
1.04
0.00
1.7
1.4
—
—
—
0
0
5
54
0.92
0.00
1.0
1.4
0.42
0.57
nmol/l
—
5
49
8
86
0.93
0.00
1.0
1.1
1.31
1.56
g/l
—
8
86
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.6
—
0.39
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
38.67
—
0
6
6
59
1.02
-0.00
1.2
1.2
—
—
—
0
0
5
52
0.96
-0.00
1.8
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
9.3
—
5.05
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
3.4
2.0
8.74
10.48
mmol/l
—
5
50
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
11
110
1.00
-0.00
1.7
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
64.00
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
19.39
—
0
7
0
5
0.00
-0.00
0.0
2.0
—
16.26
—
0
5
0
5
0.00
-0.00
0.0
5.2
—
6.60
—
0
5
0
5
0.00
-0.00
0.0
6.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint D3_OTHNONTHROMBOCYTOPENPURPURA and mortality.

Females

Parameter HR [95% CI] p-value
D3_OTHNONTHROMBOCYTOPENPURPURA 1.597 [1.33, 1.92] < 0.001
Birth year 0.993 [0.98, 1.0] 0.101

During the follow-up period (1.1.1998 — 31.12.2019), 289 out of 1034 females with D3_OTHNONTHROMBOCYTOPENPURPURA died.

Males

Parameter HR [95% CI] p-value
D3_OTHNONTHROMBOCYTOPENPURPURA 2.141 [1.7, 2.7] < 0.001
Birth year 0.99 [0.98, 1.0] 0.028

During the follow-up period (1.1.1998 — 31.12.2019), 268 out of 813 males with D3_OTHNONTHROMBOCYTOPENPURPURA died.

Mortality risk

Mortality risk for people of age

years, who have D3_OTHNONTHROMBOCYTOPENPURPURA.

N-year risk Females Males
1 0.141% 0.389%
5 0.854% 2.614%
10 2.273% 6.654%
15 4.128% 12.93%
20 7.356% 21.529%

Relationships between endpoints

↥

Index endpoint: D3_OTHNONTHROMBOCYTOPENPURPURA – Other nonthrombocytopenic purpura

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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