No definition available.
Haemorrhagic disorder due to circulating anticoagulants
EFO MESH Endpoint Browser PheWeb
D3_HAEMORRHAGCIRGUANTICO
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
579 |
4. Check minimum number of eventsNone |
579 |
5. Include endpointsNone |
579 |
6. Filter based on genotype QC (FinnGen only) |
516 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D68
- Name in latin
- Perturbatio haemorrhagica ex anticoagulantibus circulantibus
Similar endpoints
↥List of similar endpoints to
Haemorrhagic disorder due to circulating anticoagulants
based on the number of shared cases.
Similar with more cases:
- Other coagulation defects
- Coagulation defects, purpura and other haemorrhagic conditions
- Bleeding
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4217 | 1891 | 2271 |
| Only index persons | 3038 | 1409 | 1629 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.05 | 0.06 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 78.36 | 81.68 | 75.74 |
| Only index persons | 79.55 | 82.39 | 77.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 516 | 186 | 330 |
| Unadjusted period prevalence (%) | 0.12 | 0.07 | 0.15 |
| Median age at first event (years) | 77.33 | 77.12 | 77.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 538
- Matched controls
- 5380
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D68.3
ICD-10 Finland
Haemorrhagic disorder due to circulating anticoagulants
4503599627370496.0
307.7
535
*
B01AA03
ATC
warfarin; systemic
9.9
146.6
393
1159
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
22.9
114.5
87
45
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
7.3
96.8
181
349
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.4
80.7
351
1387
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
8.9
74.7
103
139
207
Kela drug reimbursment
Chronic arrhythmias
3.1
32.3
200
873
AA1AD
NOMESCO Finland
CT of head and brain
2.9
31.3
270
1404
K78
ICPC
Atrial fibrillation/flutter
3.6
30.9
120
393
R04.0
ICD-10 Finland
Epistaxis
4.0
30.9
102
299
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
9.0
30.0
38
45
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
7.0
29.0
46
71
W19
ICD-10 Finland
Unspecified fall
3.4
26.1
108
366
B01AB05
ATC
enoxaparin; parenteral
2.6
25.7
243
1290
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
25.0
170
765
TFP20
NOMESCO Finland
Cardiodefibrillation
3.5
23.8
95
314
C03CA01
ATC
furosemide; systemic
2.5
23.2
325
2043
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
9.2
22.6
28
32
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
20.8
257
1505
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.7
20.8
72
216
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.5
20.2
179
902
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
5.3
19.8
41
82
S06.3
ICD-10 Finland
Focal brain injury
8.5
19.8
26
32
C01AA05
ATC
digoxin; systemic
2.8
19.5
115
474
C07AB07
ATC
bisoprolol; oral
2.4
18.9
371
2603
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.4
18.4
173
889
I50.9
ICD-10 Finland
Heart failure, unspecified
2.3
16.9
187
1025
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
16.7
194
1085
C01BD01
ATC
amiodarone; systemic
4.9
16.6
38
83
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
15.2
135
671
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.3
15.1
60
196
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.3
15.1
154
811
D68.8
ICD-10 Finland
Other specified coagulation defects
54.8
13.9
16
*
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
9.7
13.1
26
28
I61.6
ICD-10 Finland
Intracerebral haemorrhage, multiple localized
29.2
13.0
17
6
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
12.7
12.7
22
18
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.1
12.6
56
195
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
12.5
99
464
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.0
12.3
190
1157
WX892
NOMESCO Finland
Monitored bed care
2.8
12.3
67
262
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
9.6
12.1
24
26
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
3.4
12.1
46
146
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
12.0
118
606
I48.2
ICD-10 Finland
Chronic atrial fibrillation
2.9
11.7
59
221
AAD05
NOMESCO Finland
Evacuation of acute subdural haematoma
15.5
11.4
18
12
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
4.5
11.4
28
65
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
4.7
11.3
26
57
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
11.3
218
1424
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
11.1
147
844
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.5
10.9
38
114
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
5.3
10.9
22
43
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
5.7
10.8
20
36
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.9
10.8
53
196
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
10.5
305
2245
WX730
NOMESCO Finland
Conventional respirator
5.6
10.5
20
37
ZXD05
NOMESCO Finland
Urgent procedure
1.9
10.2
185
1175
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
3.6
10.1
33
95
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
9.0
9.9
20
23
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
9.9
109
583
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
7.6
9.8
22
30
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
9.6
167
1045
WX872
NOMESCO Finland
Intensive care
2.9
9.3
44
159
K99
ICPC
Cardiovascular disease other
3.6
9.2
30
86
PA2AD
NOMESCO Finland
CT angiography of brain
15.9
9.1
14
9
I61.4
ICD-10 Finland
Intracerebral haemorrhage in cerebellum
19.0
9.0
13
7
I50
ICD-10 Finland
Heart failure
2.9
8.9
42
152
K90
ICPC
Stroke/cerebrovascular accident
3.3
8.6
33
105
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
8.6
177
1160
I50.0
ICD-10 Finland
Congestive heart failure
2.1
8.5
88
458
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
3.9
8.4
25
67
I48.1
ICD-10 Finland
Persistent atrial fibrillation
2.7
8.3
46
181
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.2
8.1
32
104
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
17.5
8.1
12
7
R06
ICPC
Nose bleed/epistaxis
3.8
8.1
25
69
C01BC04
ATC
flecainide; systemic
3.1
7.8
33
112
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
2.3
7.8
61
283
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
7.8
104
592
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.5
7.8
27
81
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.2
7.7
70
345
S06.0
ICD-10 Finland
Concussion
2.1
7.7
74
373
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.7
7.6
40
153
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
81.2
7.4
8
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.6
7.3
41
163
B01AF01
ATC
rivaroxaban; oral
1.9
7.3
94
529
N30.9
ICD-10 Finland
Cystitis, unspecified
2.5
7.2
46
195
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.9
7.1
33
118
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
7.1
73
378
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.1
7.1
71
364
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
3.6
7.1
23
66
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
4.3
7.1
18
43
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.5
6.9
42
173
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.6
6.9
40
162
M10.9
ICD-10 Finland
Gout, unspecified
2.1
6.8
64
320
UJF32
NOMESCO Finland
Coloscopy
1.7
6.8
159
1068
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.3
6.8
50
226
XF404
NOMESCO Finland
Ambulatory ECG
2.1
6.7
68
351
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
2.6
6.5
36
142
M04AA01
ATC
allopurinol; systemic
1.8
6.5
111
682
AAD15
NOMESCO Finland
Evacuation of traumatic intracerebral haematoma
70.7
6.4
7
*
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
70.7
6.4
7
*
WW200, ,
SPAT
0.5
6.4
52
995
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
5.3
6.4
18
35
K83
ICPC
Heart valve disease NOS
5.6
6.3
17
31
A46
ICD-10 Finland
Erysipelas
1.8
6.3
106
647
126
Kela drug reimbursment
Chronic coagulation defects
+∞
6.3
6
*
D68.2
ICD-10 Finland
Hereditary deficiency of other clotting factors
+∞
6.3
6
*
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
6.3
6
*
X59.9
ICD-10 Finland
Exposure to unspecified factor causing other and unspecified injury
+∞
6.3
6
*
B01AE07
ATC
dabigatran etexilate; oral
2.7
6.3
33
127
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
3.2
6.2
24
77
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
5.1
6.2
18
36
R55
ICD-10 Finland
Syncope and collapse
1.9
6.2
87
502
SPAT1254
SPAT
Administration of medicine
1.8
6.2
104
635
D64.9
ICD-10 Finland
Anaemia, unspecified
1.8
6.2
93
549
E000003, ,
ATC
3.0
6.1
26
89
205
Kela drug reimbursment
Chronic hypertension
1.6
6.1
204
1493
S16
ICPC
Bruise/contusion
3.1
6.0
25
84
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
2.1
6.0
60
307
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
204
823
3.38
38.77
4.5
1.8
34.86
29.65
s
9.20
198
794
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
82
190
4.91
33.82
4.1
2.6
0.33
0.37
iu/ml
0.50
56
108
390
2544
2.94
27.92
55.3
20.2
1.92
1.39
inr
37.28
354
2167
260
1516
2.38
21.41
3.4
2.1
223.93
290.06
u/l
0.54
247
1432
170
841
2.49
19.94
4.3
3.1
0.81
0.82
mmol/l
0.36
154
790
44
95
4.96
19.51
4.5
1.9
92.34
85.47
%
1.03
44
89
114
493
2.67
17.45
11.7
6.7
12.40
11.85
mmol/l
0.26
109
467
145
704
2.45
17.42
7.1
5.6
1.02
1.04
mmol/l
0.28
136
650
188
1143
1.99
12.23
3.5
2.7
—
—
—
0
0
124
652
2.17
11.88
5.4
3.9
275.77
244.40
u/l
0.88
119
615
151
895
1.96
10.29
3.8
2.6
2.23
2.22
g/l
0.05
134
828
142
839
1.94
9.70
4.2
2.7
18.55
21.23
%
1.90
129
779
67
297
2.43
9.49
1.6
1.5
1.59
1.62
g/l
0.08
59
270
122
693
1.98
9.31
10.8
7.4
0.77
1.11
mmol/l
0.31
104
558
94
489
2.12
9.10
5.8
3.3
442.28
276.47
ng/l
2.23
86
454
154
957
1.85
8.92
4.0
2.6
9.89
11.75
umol/l
3.25
141
885
121
699
1.94
8.74
11.0
7.3
5.01
5.11
kpa
0.51
115
674
278
2062
1.72
8.68
3.8
3.1
—
—
estimate
—
0
0
303
2309
1.71
8.50
10.2
6.7
1.19
1.21
mmol/l
5.21
282
2107
175
1145
1.78
8.49
7.3
4.1
68.34
82.21
%
6.75
168
1125
29
86
3.51
8.47
1.1
1.2
—
—
—
0
0
120
700
1.92
8.40
11.1
7.3
11.53
11.46
kpa
0.05
113
674
210
1457
1.72
8.25
3.5
2.4
3.68
3.12
mg/l
1.63
183
1241
351
2818
1.71
7.82
8.6
5.3
7.20
6.90
mmol/l
1.60
341
2702
19
32
6.11
7.44
1.2
1.1
—
—
—
0
0
271
2053
1.64
7.38
6.6
4.5
40.71
90.17
ng/l
0.87
233
1669
157
1036
1.73
7.21
2.3
1.9
—
—
—
0
0
321
2549
1.64
7.16
11.9
7.3
1.19
1.21
mmol/l
4.99
271
2174
41
167
2.58
6.94
3.5
3.3
0.74
0.86
nmol/l
1.06
32
140
162
1089
1.70
6.91
2.0
1.8
1184.04
1164.49
nmol/l
0.07
115
828
253
1908
1.62
6.85
6.1
3.4
2873.43
2081.68
ng/l
1.76
219
1683
12
12
10.20
6.56
1.3
1.2
—
—
—
0
0
88
502
1.90
6.49
3.0
2.5
6.59
6.40
ug/l
0.05
75
433
286
2259
1.57
6.12
6.7
4.9
32.24
34.46
g/l
7.74
265
2103
74
410
1.93
5.95
2.1
1.8
—
—
—
0
0
86
502
1.85
5.90
1.7
3.0
64.26
66.14
g/l
1.24
79
457
17
36
4.84
5.65
1.6
1.1
7.17
4.46
u/ml
—
6
13
61
322
2.01
5.63
6.5
4.0
2.88
2.11
mmol/l
0.48
42
233
139
942
1.64
5.60
4.5
1.7
2.60
1.59
mg/l
1.35
110
757
31
124
2.59
5.47
1.5
1.5
299.56
267.27
ug/g
0.37
16
71
101
1517
0.59
5.43
2.2
2.0
1.32
1.28
mmol/l
0.19
82
1226
33
138
2.48
5.33
3.0
3.9
1.88
1.60
index
0.11
17
78
46
223
2.16
5.31
2.1
1.8
—
—
—
0
0
41
191
2.24
5.21
2.5
3.5
2.46
2.66
ratio
0.07
26
113
41
195
2.19
4.97
7.0
4.7
25.40
25.04
mmol/l
0.21
35
181
165
1205
1.53
4.73
3.6
3.1
393.16
371.03
umol/l
1.18
135
1032
302
2496
1.48
4.71
8.2
6.2
13.26
12.30
umol/l
0.81
287
2363
32
142
2.33
4.57
2.1
1.4
—
—
—
0
0
43
217
2.07
4.50
2.4
3.7
37.44
49.05
mg/l
0.50
34
190
65
379
1.81
4.46
6.7
3.9
5.37
5.15
kpa
0.75
57
364
18
60
3.07
4.43
2.1
1.8
88.72
89.21
%
0.12
18
60
41
207
2.06
4.29
2.0
1.7
—
—
—
0
0
42
215
2.03
4.24
2.5
3.7
62.86
83.08
mg/l
0.31
35
187
67
403
1.76
4.15
1.9
1.6
—
—
—
0
0
192
1483
1.46
4.08
2.7
2.5
57.40
118.79
u/l
0.59
178
1371
288
2406
1.42
3.96
4.1
3.3
61.69
57.94
u/l
0.34
264
2208
84
547
1.63
3.89
5.2
3.8
—
—
—
0
0
40
209
1.99
3.84
2.0
2.7
0.42
1.07
g/l
0.91
33
181
28
127
2.27
3.83
1.4
1.3
—
—
—
0
0
28
127
2.27
3.83
1.4
1.3
—
—
—
0
0
40
211
1.97
3.74
1.9
2.4
10.12
10.92
g/l
0.74
35
185
35
179
2.02
3.57
3.1
3.0
3.74
4.22
pmol/l
1.99
29
161
26
118
2.26
3.57
2.0
1.5
—
—
—
0
0
110
785
1.50
3.42
2.1
1.8
—
—
—
0
0
46
263
1.82
3.40
2.0
1.8
1.93
2.92
ug/l
0.30
35
224
38
207
1.90
3.26
1.5
1.3
—
—
—
0
0
104
743
1.50
3.21
2.2
1.8
—
—
—
0
0
51
308
1.72
3.15
1.5
1.5
—
—
—
0
0
43
247
1.81
3.14
1.9
2.4
7.57
7.51
g/l
0.07
38
222
43
247
1.81
3.14
1.9
2.4
4.13
4.19
g/l
0.16
38
222
43
247
1.81
3.14
1.9
2.4
4.04
3.76
g/l
0.56
38
222
170
1341
1.39
3.07
4.2
3.2
40.24
37.21
u/l
0.19
152
1268
40
231
1.79
2.88
1.9
2.4
3.57
3.03
g/l
1.82
35
206
7
13
5.44
2.87
1.9
1.2
—
—
—
0
0
12
38
3.21
2.86
1.3
1.1
44.33
42.50
u/l
0.08
12
32
63
413
1.60
2.86
5.1
4.2
119.31
97.64
ng/l
1.06
55
357
60
390
1.61
2.82
10.5
6.7
25.01
24.32
mmol/l
0.54
54
375
0
75
0.00
2.77
0.0
1.7
—
212.77
—
0
70
61
400
1.59
2.77
1.9
1.8
378.65
400.30
nmol/l
0.36
54
364
13
48
2.75
2.73
1.1
2.0
—
—
—
0
0
284
2459
1.33
2.71
9.9
8.8
4.90
4.41
e9/l
2.20
247
2124
372
3353
1.35
2.68
11.8
8.2
83.86
82.75
u/l
0.17
349
3160
12
43
2.83
2.66
1.1
1.7
—
—
—
0
0
12
43
2.83
2.66
1.1
1.7
—
—
—
0
0
12
43
2.83
2.66
1.1
1.7
—
—
—
0
0
136
1057
1.38
2.64
6.7
4.3
202.77
326.92
ng/l
0.68
126
933
178
1452
1.34
2.52
4.5
3.7
0.38
0.50
e6/l
0.60
148
1115
11
37
3.01
2.50
1.6
1.3
—
—
—
0
0
49
314
1.62
2.46
1.8
1.6
1.56
1.62
%
0.30
41
264
15
66
2.31
2.26
1.4
1.3
—
—
—
0
0
74
532
1.45
2.22
2.6
2.6
13.67
8.53
umol/l
0.89
67
472
8
24
3.37
2.18
1.0
1.8
—
—
—
0
0
8
24
3.37
2.18
1.0
1.8
—
—
—
0
0
8
24
3.37
2.18
1.0
1.8
—
—
—
0
0
8
24
3.37
2.18
1.0
1.8
—
—
—
0
0
227
1948
1.29
2.16
4.6
3.1
164.23
155.18
ug/l
0.19
200
1765
18
88
2.08
2.13
1.7
1.7
—
—
—
0
0
8
25
3.23
2.10
2.3
1.4
3.75
9.80
u/l
—
8
20
10
37
2.73
2.08
1.7
1.3
—
—
—
0
0
7
20
3.53
2.06
1.0
2.0
—
—
—
0
0
7
20
3.53
2.06
1.0
2.0
—
—
—
0
0
24
134
1.83
1.98
3.0
2.1
124.14
126.33
g/l
0.09
14
101
7
21
3.36
1.97
1.3
1.9
—
—
—
0
0
150
1239
1.29
1.88
3.5
2.9
6.86
4.56
e6/l
0.63
140
1131
11
46
2.42
1.86
1.1
2.0
—
—
—
0
0
201
1725
1.26
1.85
3.7
3.4
2.32
2.35
mmol/l
2.51
172
1544
17
88
1.96
1.76
1.4
1.4
—
—
—
0
0
15
74
2.06
1.76
4.0
3.2
27.00
21.63
mg/l
—
5
32
7
24
2.94
1.72
1.9
3.0
—
—
—
0
0
22
126
1.78
1.70
1.5
1.5
—
—
—
0
0
12
55
2.21
1.68
2.3
3.0
—
—
—
0
0
6
19
3.18
1.66
1.2
1.1
—
—
—
0
0
22
130
1.72
1.55
1.5
1.6
—
—
—
0
0
13
64
2.06
1.55
2.0
1.4
—
—
—
0
0
5
15
3.35
1.52
2.8
1.4
0.61
0.62
mmol/l
—
5
15
15
79
1.92
1.50
1.1
1.4
68996.00
26665.79
e6/l
—
10
48
5
16
3.14
1.44
1.0
1.0
—
—
—
0
0
423
4005
1.26
1.42
37.4
20.6
30.11
28.33
mg/l
0.63
396
3455
21
127
1.68
1.38
1.3
1.2
—
—
—
0
0
6
23
2.63
1.37
1.7
1.1
—
—
—
0
0
6
23
2.63
1.37
1.7
1.1
—
—
—
0
0
21
128
1.67
1.35
1.7
1.6
0.11
41.47
iu/ml
—
6
29
76
600
1.31
1.34
5.6
3.7
1.61
1.88
mmol/l
0.19
65
499
22
342
0.63
1.34
2.1
2.1
7.40
12.68
nmol/l
3.45
17
297
194
1709
1.21
1.33
4.6
3.9
77.13
103.65
e6/l
0.18
164
1353
14
76
1.86
1.31
1.5
1.4
—
—
—
0
0
5
18
2.79
1.28
1.8
2.5
—
—
—
0
0
103
851
1.26
1.28
4.1
3.6
2.84
1.79
e6/l
0.46
58
465
337
3136
1.20
1.25
6.0
4.4
20.47
15.41
mm/h
3.70
298
2870
8
36
2.24
1.24
2.4
2.4
—
—
—
0
0
57
437
1.34
1.24
2.9
2.5
28.39
35.36
u/l
1.15
51
361
9
45
2.02
1.24
1.3
1.6
—
243.33
—
0
6
21
132
1.61
1.22
1.6
1.3
—
—
—
0
0
5
19
2.65
1.22
1.2
1.6
1.40
3.71
u/field
—
5
14
5
19
2.65
1.22
2.4
1.7
121.08
51.89
ug/l
—
5
19
20
126
1.61
1.16
1.4
1.2
—
—
—
0
0
8
39
2.07
1.15
1.0
1.2
—
—
—
0
0
16
96
1.69
1.11
1.7
1.4
—
—
—
0
0
7
31
2.27
1.10
2.0
3.7
0.71
0.77
index
—
7
31
68
545
1.28
1.09
15.2
8.9
—
—
—
0
0
53
411
1.32
1.08
5.9
3.5
1.20
1.22
mmol/l
2.30
46
351
9
48
1.89
1.01
1.0
1.0
—
—
—
0
0
17
107
1.61
1.00
1.6
1.4
—
—
—
0
0
10
54
1.87
0.97
1.1
1.1
—
—
—
0
0
21
141
1.51
0.96
2.3
1.5
3.66
10.55
iu/ml
—
8
37
66
538
1.26
0.94
4.8
5.2
31.44
32.59
%
0.40
39
338
19
126
1.53
0.92
2.3
1.6
13197.50
13466.97
e6/l
0.01
12
89
22
151
1.48
0.92
1.3
1.4
—
—
—
0
0
14
86
1.64
0.91
1.1
1.2
—
—
—
0
0
360
3774
0.86
0.88
34.4
20.5
66.79
70.53
ml/min/173m2
2.23
338
3565
10
56
1.80
0.88
1.9
1.3
—
—
—
0
0
6
32
1.88
0.82
2.7
1.3
—
—
—
0
0
74
623
1.22
0.81
1.3
1.3
47.98
35.96
iu/ml
0.33
24
214
8
47
1.71
0.81
1.0
1.3
—
—
—
0
0
10
58
1.74
0.80
1.9
1.3
—
—
—
0
0
10
58
1.74
0.80
1.9
1.3
—
—
—
0
0
430
4152
1.18
0.79
43.8
25.6
139.01
139.51
mmol/l
2.88
413
4064
430
4156
1.17
0.76
44.0
25.8
3.99
4.03
mmol/l
2.40
413
4065
0
28
0.00
0.76
0.0
3.4
—
0.61
—
0
28
20
141
1.43
0.75
2.0
1.3
—
—
—
0
0
9
54
1.68
0.75
1.3
1.6
—
—
—
0
0
9
56
1.62
0.72
2.0
1.3
—
—
—
0
0
9
56
1.62
0.72
2.0
1.3
—
—
—
0
0
9
57
1.59
0.71
2.0
1.3
—
—
—
0
0
93
1055
0.86
0.67
6.4
5.1
1.02
1.02
kg/l
0.08
70
718
359
3735
0.88
0.67
5.3
5.2
1.33
1.41
mmol/l
3.72
304
3356
5
28
1.79
0.66
2.2
1.3
—
—
—
0
0
102
903
1.16
0.65
3.6
3.5
0.84
1.13
e6/l
0.78
58
519
43
352
1.24
0.63
3.0
3.2
53.59
54.69
ml/min/173m2
0.09
29
154
124
1118
1.14
0.62
1.9
1.9
448.45
6216362.32
pmol/l
0.50
91
917
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
240
2260
1.11
0.58
2.8
2.3
87.85
93.60
pmol/l
1.47
138
1193
434
4227
1.14
0.55
51.7
30.7
92.17
91.91
fl
0.42
420
4160
434
4227
1.14
0.55
51.9
30.7
230.81
236.15
e9/l
0.81
414
4129
315
3015
1.11
0.55
4.2
3.9
15.21
15.14
pmol/l
0.15
272
2673
434
4228
1.14
0.55
51.8
30.7
4.21
4.35
e12/l
4.60
413
4118
434
4228
1.14
0.55
53.3
31.3
37.81
39.21
%
4.59
420
4157
12
82
1.47
0.54
3.5
3.0
12.49
10.01
pmol/l
0.36
12
82
434
4230
1.13
0.53
52.3
30.9
126.04
131.23
g/l
7.73
422
4159
149
1612
0.90
0.53
4.4
5.1
22.92
22.04
%
0.30
73
870
6
40
1.51
0.51
1.3
1.2
—
—
—
0
0
9
64
1.41
0.51
2.2
1.4
—
—
—
0
0
106
1167
0.89
0.51
3.2
3.4
0.70
0.82
ug/l
0.83
73
829
431
4203
1.13
0.51
45.0
27.7
97.03
88.08
umol/l
2.63
418
4137
21
163
1.30
0.49
1.0
1.1
180.17
161.29
u/ml
—
6
47
123
1128
1.12
0.48
3.5
3.0
2.46
2.46
mmol/l
0.26
104
1007
20
155
1.30
0.47
1.4
1.3
—
—
—
0
0
18
139
1.31
0.44
1.6
1.4
—
—
—
0
0
63
559
1.14
0.42
1.2
1.3
20.97
13.38
u/ml
0.23
16
194
221
2320
0.92
0.41
5.8
4.6
0.00
0.00
estimate
-0.00
61
504
65
579
1.14
0.41
3.4
4.0
12.10
29.10
ug/l
0.53
53
498
5
35
1.43
0.39
1.0
1.2
91.20
91.69
pmol/l
—
5
35
0
19
0.00
0.39
0.0
1.1
—
1.06
—
0
10
367
3767
0.92
0.38
7.6
7.4
40.72
40.79
mmol/mol
0.05
315
3452
18
225
0.79
0.38
4.8
3.4
271.31
1201.30
u/ml
0.77
13
191
5
36
1.39
0.38
1.6
1.1
—
—
—
0
0
9
69
1.31
0.37
10.9
2.1
11.13
10.29
mmol/l
—
9
69
11
81
1.37
0.36
1.1
1.1
—
17.17
—
0
6
145
1362
1.09
0.36
5.8
4.7
0.00
0.00
estimate
0.50
52
444
24
285
0.83
0.33
1.9
1.3
—
—
—
0
0
170
1615
1.08
0.32
4.3
4.2
26.05
10.11
mg/mmol
1.57
114
1067
378
3863
0.93
0.32
5.7
6.2
2.22
2.45
mmol/l
5.51
324
3485
307
3159
0.93
0.31
44.4
25.8
14.75
14.02
%
11.36
301
3120
7
55
1.28
0.30
1.6
2.6
1444.86
1178.00
mg
—
7
55
8
109
0.73
0.29
1.4
1.3
—
—
—
0
0
369
3765
0.94
0.27
5.1
5.3
4.05
4.31
mmol/l
5.16
321
3414
417
4103
1.07
0.26
16.8
12.8
24.93
24.14
u/l
0.48
391
3962
227
2345
0.94
0.25
5.7
4.7
44.06
6.69
estimate
0.63
64
524
303
3103
0.95
0.24
44.4
27.7
329.24
330.70
g/l
1.61
296
3078
12
97
1.24
0.23
1.6
1.6
—
—
—
0
0
5
42
1.19
0.21
1.8
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
13.80
—
0
10
0
10
0.00
0.21
0.0
1.0
—
1.15
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
34
306
1.12
0.21
1.8
1.5
—
—
—
0
0
200
1936
1.05
0.21
2.9
2.4
75.70
79.28
nmol/l
1.07
168
1699
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
207
2006
1.05
0.21
5.2
6.1
4.68
5.32
ug/l
0.09
181
1774
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
351
3571
0.95
0.20
4.7
4.5
1.29
1.24
mmol/l
0.55
296
3172
6
48
1.25
0.20
1.3
1.2
35080.50
264069.56
e6/l
—
6
32
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
6
52
1.16
0.19
2.0
1.4
—
—
—
0
0
7
60
1.17
0.18
1.6
1.6
—
—
—
0
0
170
1753
0.96
0.17
6.0
4.8
0.00
0.04
estimate
1.91
52
419
36
391
0.92
0.16
1.2
1.4
—
—
—
0
0
230
2353
0.96
0.16
5.8
4.7
0.05
0.62
estimate
0.45
59
492
8
72
1.11
0.16
1.4
1.3
—
—
—
0
0
126
1216
1.05
0.15
5.3
4.2
0.00
0.10
estimate
0.85
50
388
371
3662
1.04
0.15
5.5
5.1
2.05
2.05
mu/l
0.01
318
3279
13
148
0.88
0.12
8.5
3.4
8.12
7.59
mmol/l
0.33
13
143
161
1577
1.03
0.09
3.5
3.4
6.29
7.16
mmol/l
2.15
121
1308
6
58
1.03
0.08
1.0
1.1
—
—
—
0
0
5
63
0.79
0.08
1.0
1.3
7.00
14.12
u/l
—
5
58
165
1621
1.03
0.08
2.0
1.9
18.77
19.89
nmol/l
0.45
137
1347
12
133
0.90
0.07
2.2
1.8
—
—
—
0
0
8
77
1.04
0.07
1.3
1.2
—
1.00
—
0
5
79
771
1.03
0.06
1.2
1.3
0.75
1.20
u/ml
1.23
18
184
11
121
0.91
0.06
2.0
1.7
—
—
—
0
0
193
1914
1.01
0.03
2.9
2.5
—
—
—
0
0
381
3824
0.99
0.03
5.5
5.7
6.16
6.15
mmol/l
0.03
316
3429
15
155
0.97
0.00
1.0
1.0
—
—
—
0
0
22
223
0.99
0.00
2.0
2.9
—
—
—
0
0
11
112
0.98
0.00
1.2
1.7
14.97
13.93
mg/l
0.10
11
101
17
169
1.01
0.00
6.8
3.4
1.98
1.67
mmol/l
0.31
17
164
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
44.80
—
0
5
0
5
0.00
0.00
0.0
10.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
13.46
—
0
8
6
61
0.98
-0.00
2.7
4.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.3
—
96.75
—
0
6
9
93
0.97
-0.00
1.2
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
52.60
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
9.6
—
10.70
—
0
7
0
6
0.00
-0.00
0.0
2.5
—
39.00
—
0
6
7
77
0.91
-0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_HAEMORRHAGCIRGUANTICO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMORRHAGCIRGUANTICO | 2.704 [1.88, 3.89] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 431 females with D3_HAEMORRHAGCIRGUANTICO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMORRHAGCIRGUANTICO | 2.812 [1.94, 4.07] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 470 males with D3_HAEMORRHAGCIRGUANTICO died.
Mortality risk
Mortality risk for people of age
years, who have D3_HAEMORRHAGCIRGUANTICO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | 0.516% |
| 5 | 1.195% | 2.941% |
| 10 | 3.153% | 7.068% |
| 15 | 5.678% | 12.913% |
| 20 | 10.172% | 21.439% |
Relationships between endpoints
↥Index endpoint: D3_HAEMORRHAGCIRGUANTICO – Haemorrhagic disorder due to circulating anticoagulants
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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