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Selective deficiency of immunoglobulin G [IgG] subclasses

DOID EFO Endpoint Browser PheWeb

D3_DEF_IGG

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D80.3
  • Cause of death: ICD-10 — D80.3

2 out of 7 registries used, show all original rules.

277

4. Check minimum number of events

None

277

5. Include endpoints

None

277

6. Filter based on genotype QC (FinnGen only)

245

Control definitions (FinnGen only)

Control exclude
D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D80
Name in latin
Deficientia selectiva subclassium immunoglobulini G

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1014 665 344
Only index persons 956 637 319
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 43.56 45.95 38.66
Only index persons 44.64 46.75 40.42

-FinnGen-

Key figures

All Female Male
Number of individuals 245 181 64
Unadjusted period prevalence (%) 0.06 0.06 0.03
Median age at first event (years) 47.83 47.72 48.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
258
Matched controls
2580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
307.7
258
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
26.6
116.8
90
51
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
96.0
86
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
26.3
93.7
70
36
J01MA12
ATC
levofloxacin; systemic
10.9
84.6
140
254
J01MA14
ATC
moxifloxacin; systemic
13.2
83.8
99
116
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
17.8
83.1
76
59
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
82.9
75
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
81.7
74
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
29.4
77.2
54
23
WW200
NOMESCO Finland
Immunization
28.6
69.7
49
21
J45.1
ICD-10 Finland
Nonallergic asthma
11.7
68.4
84
102
R03DC03
ATC
montelukast; oral
8.6
67.1
132
281
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
10.8
66.9
89
120
J45.9
ICD-10 Finland
Asthma, unspecified
7.9
62.2
137
324
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
62.0
57
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
9.6
61.0
90
137
H02AB06
ATC
prednisolone; systemic
12.0
60.3
221
857
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
58.6
54
*
ZX120
NOMESCO Finland
Intravenous
9.2
57.9
88
138
TDM10
NOMESCO Finland
Puncture of maxillary antrum
14.3
57.1
57
50
J47
ICD-10 Finland
Bronchiectasis
25.5
56.2
41
19
J45.8
ICD-10 Finland
Mixed asthma
20.4
53.5
43
25
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
7.0
53.1
123
299
R03BB04
ATC
tiotropium bromide; inhalant
9.9
52.9
71
95
H02AB07
ATC
prednisone; oral
7.7
51.5
94
179
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
10.5
50.2
63
77
GD1AA
NOMESCO Finland
Thorax X-ray examination
7.2
45.7
200
835
R50.9
ICD-10 Finland
Fever, unspecified
6.3
43.2
100
237
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.2
41.9
65
102
TPH04
NOMESCO Finland
Cathetrisation of vein
5.6
41.7
122
355
R03AK08
ATC
formoterol and beclometasone; inhalant
10.8
39.9
47
52
UGC12
NOMESCO Finland
Flexible bronchoscopy
10.2
39.6
49
58
R03DA04
ATC
theophylline; systemic, rectal
13.0
39.0
40
36
R03AC12
ATC
salmeterol; inhalant
11.8
38.2
42
42
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.3
37.6
114
337
J01FA15
ATC
telithromycin; oral
6.5
36.9
73
147
R03BA02
ATC
budesonide; inhalant
5.2
36.7
109
316
R03AK06
ATC
salmeterol and fluticasone; inhalant
5.8
36.4
87
209
A07AA02
ATC
nystatin; oral
9.1
35.7
48
63
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
35.2
33
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
11.9
35.1
38
37
J01FF01
ATC
clindamycin; systemic
4.8
35.0
131
454
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.9
34.7
63
116
H02AB09
ATC
hydrocortisone; systemic
12.9
34.3
35
31
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
4.9
33.4
108
332
J01FA06
ATC
roxithromycin; oral
4.8
33.2
171
747
J01MA02
ATC
ciprofloxacin; systemic
4.7
33.2
154
623
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.5
33.1
81
197
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.6
32.5
131
475
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
7.4
32.4
53
87
J46
ICD-10 Finland
Status asthmaticus
12.5
31.7
33
30
H02AB04
ATC
methylprednisolone; systemic
5.2
31.4
83
215
UDH02
NOMESCO Finland
Rhinopharyngoscopy
6.7
31.2
57
105
C01CA24
ATC
epinephrine; parenteral
6.5
30.5
58
111
Z01.8
ICD-10 Finland
Other specified special examinations
4.5
30.5
111
370
J01.0
ICD-10 Finland
Acute maxillary sinusitis
4.3
30.3
136
528
J01FA09
ATC
clarithromycin; systemic
4.3
30.2
145
591
R03AC13
ATC
formoterol; inhalant
8.7
29.8
41
55
UJF30
NOMESCO Finland
Ileoscopy through colon
5.6
28.6
65
147
XQ800
NOMESCO Finland
Prick test
6.1
28.0
56
112
XG474
NOMESCO Finland
Exhalation nntrogen oxide
10.4
28.0
33
36
J45
ICD-10 Finland
Asthma
5.4
27.7
66
155
R03BB01
ATC
ipratropium bromide; inhalant
10.9
27.3
31
32
R03BA05
ATC
fluticasone; inhalant
4.2
26.4
99
332
M79.0
ICD-10 Finland
Rheumatism, unspecified
8.6
25.7
35
46
C03CA01
ATC
furosemide; systemic
4.1
25.2
96
324
6BA02, ,
NOMESCO Finland
143.9
25.1
26
*
R01AD05
ATC
budesonide; nasal
5.9
24.9
51
104
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
4.6
24.7
203
1147
D84.18
ICD-10 Finland
Other specified defect in the complement system
+∞
24.4
23
*
GD1AD
NOMESCO Finland
Thorax CT examination
7.4
24.2
38
59
R03BA01
ATC
beclometasone; inhalant
4.6
24.2
72
202
XW000
NOMESCO Finland
Bone marrow biopsy
9.6
24.1
30
35
XG410
NOMESCO Finland
Flow-volume spirometry
8.6
23.5
32
42
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
23.3
22
*
R06.0
ICD-10 Finland
Dyspnoea
3.7
22.9
110
431
N03AX16
ATC
[U] pregabalin
3.8
22.8
102
381
R03AC03
ATC
terbutaline; inhalant
4.3
22.7
72
211
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
4.1
22.2
79
252
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.7
22.1
61
160
R01AD08
ATC
fluticasone; nasal
3.5
22.0
127
558
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.9
21.7
56
139
J01FA10
ATC
azithromycin; systemic
4.7
21.7
214
1317
ZX112
NOMESCO Finland
Subcutaneous
9.9
21.6
26
29
R03BA08
ATC
ciclesonide; inhalant
4.8
21.5
57
145
R03AC02
ATC
salbutamol; inhalant
4.1
21.1
201
1195
J31.0
ICD-10 Finland
Chronic rhinitis
4.7
20.9
57
148
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.4
20.6
130
597
J32.4
ICD-10 Finland
Chronic pansinusitis
21.0
20.5
30
16
R03AK07
ATC
formoterol and budesonide; inhalant
3.5
20.3
97
375
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
39.3
20.2
25
7
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
6.6
20.2
35
60
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.4
20.2
117
509
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
113.9
19.9
21
*
TAB00
NOMESCO Finland
Lumbar puncture
5.9
19.8
39
76
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
6.1
19.7
37
69
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.1
19.6
46
105
R01AD09
ATC
mometasone; nasal
3.4
19.5
173
964
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.2
18.8
43
96
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
3.7
18.7
196
1195
J20
ICD-10 Finland
Acute bronchitis
4.1
18.7
62
186
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
8.5
18.6
25
32
M05BA04
ATC
alendronic acid; oral
5.3
18.5
41
89
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.5
18.5
39
81
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
6.2
18.4
34
62
TGC00
NOMESCO Finland
Bronchial lavation
16.2
18.1
29
20
N03AX12
ATC
[U] gabapentin; oral
3.6
18.0
78
280
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
17.9
17
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
17.9
17
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
7.0
17.5
28
44
N05BA01
ATC
diazepam; systemic, rectal
3.8
17.3
62
196
A02BC05
ATC
esomeprazole; systemic
3.0
17.2
144
757
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
27.9
17.2
23
9
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.7
17.2
45
112
J02AC01
ATC
fluconazole; systemic
3.0
16.9
155
855
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.6
16.9
68
232
N06AX21
ATC
duloxetine; oral
3.7
16.8
65
216
N02AX02
ATC
tramadol; systemic, rectal
3.0
16.6
148
801
J01AA02
ATC
doxycycline; systemic
5.5
16.4
235
1681
R01BA52
ATC
pseudoephedrine, combinations; oral
3.0
16.2
114
541
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
4.5
16.2
44
113
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.2
16.1
48
132
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.9
15.8
53
159
N02AA05
ATC
oxycodone; systemic
3.5
15.8
66
230
J01.9
ICD-10 Finland
Acute sinusitis, unspecified
5.6
15.7
32
64
R06AE09
ATC
levocetirizine; oral
3.5
15.5
67
238
A41.9
ICD-10 Finland
Sepsis, unspecified
13.0
15.5
27
23
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
15.4
57
183
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
5.9
15.3
29
54
C03DA01
ATC
spironolactone; oral
4.0
15.2
50
148
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.0
15.2
49
143
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
34.0
15.0
19
6
R01AD58
ATC
fluticasone, combinations; nasal
2.9
15.0
105
493
A03FA01
ATC
metoclopramide; systemic, rectal
3.0
15.0
94
416
Z3231
NOMESCO Finland
Registered nurse
2.9
14.9
104
487
WZC30
NOMESCO Finland
Teaching
3.2
14.8
74
287
A01AB09
ATC
miconazole; local oral
4.5
14.8
40
102
D84.9
ICD-10 Finland
Immunodeficiency, unspecified
+∞
14.7
14
*
D80.6
ICD-10 Finland
Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
+∞
14.7
14
*
WE300
NOMESCO Finland
Profylactive therapy of malignancy with biomoidiers
+∞
14.7
14
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.8
14.6
52
162
R13
ICD-10 Finland
Dysphagia
4.6
14.5
37
90
SPAT1255
SPAT
Intravenous administration of medicine
5.6
14.5
29
57
E0000UV, ,
ATC
2.8
14.5
148
842
N06AA09
ATC
amitriptyline; systemic
4.0
14.4
45
128
R06AE07
ATC
cetirizine; oral
2.8
14.1
154
901
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.5
14.1
37
92
R01BA51
ATC
phenylpropanolamine, combinations; oral
3.5
14.0
55
183
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
13.8
57
196
XF400
NOMESCO Finland
ECG with 12 standard connections
3.4
13.7
59
208
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.6
13.7
52
169
ZXA10
NOMESCO Finland
Bilateral
3.1
13.7
70
274
GD1DG
NOMESCO Finland
Extremely extensive MRI examination of pleura with high field magnet
+∞
13.7
13
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.0
13.7
81
345
UJF32
NOMESCO Finland
Coloscopy
2.9
13.5
89
401
Z3226
NOMESCO Finland
Physiotherapist
3.0
13.4
74
302
R01AD12
ATC
fluticasone furoate; nasal
2.7
13.3
120
634
N03AE01
ATC
clonazepam; systemic
4.9
13.2
31
70
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
12.5
13.1
23
20
J01DA06
ATC
[U] cefuroxime
3.1
13.0
65
250
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.6
13.0
141
812
R03AK03
ATC
[U] fenoterol and ipratropium bromide
6.2
13.0
23
40
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
3.7
13.0
47
148
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.4
12.9
53
181
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
5.9
12.8
24
44
P01BA02
ATC
hydroxychloroquine; oral
3.9
12.8
42
123
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.2
12.7
59
217
R53
ICD-10 Finland
Malaise and fatigue
2.7
12.7
94
448
S01GX01
ATC
cromoglicic acid; ophthalmic
2.8
12.7
86
392
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.2
12.6
37
100
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
5.8
12.6
24
45
N03AX11
ATC
topiramate; oral
5.5
12.5
25
49
R06AX27
ATC
desloratadine; oral
2.6
12.5
113
594
Z2221
NOMESCO Finland
Medical doctor
2.6
12.3
100
498
WX002
NOMESCO Finland
Sedation and analgesia
3.0
12.2
69
284
WVC10
NOMESCO Finland
Subcutaneous infusion of drugs
28.3
12.2
16
6
M79.7
ICD-10 Finland
Fibromyalgia
5.1
12.2
27
58
J05AB11
ATC
valaciclovir; oral
2.9
12.2
70
291
R03DC01
ATC
zafirlukast; oral
14.3
12.2
20
15
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.5
12.1
46
149
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.4
12.1
32
80
JN4BD
NOMESCO Finland
Extensive body CT
3.7
12.0
43
134
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
49.1
12.0
14
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.8
12.0
81
367
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.5
11.9
45
145
X59
ICD-10 Finland
Exposure to unspecified factor
2.8
11.9
74
321
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.7
11.8
29
68
R06AX22
ATC
ebastine; oral
2.8
11.7
73
316
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.9
11.7
67
278
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.7
11.6
40
121
R05
ICD-10 Finland
Cough
2.7
11.6
82
379
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
11.5
11
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.6
11.5
23
26
P01AB01
ATC
metronidazole; oral, rectal
2.5
11.5
140
836
A07AA09
ATC
vancomycin; oral
18.1
11.4
17
10
ZYC01
NOMESCO Finland
Remote contact by phone
3.9
11.3
36
103
A03CA02
ATC
clidinium and psycholeptics; oral
4.9
11.2
26
58
N05CF01
ATC
zopiclone; oral
2.5
11.2
106
563
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
11.1
92
458
J01DB01
ATC
cefalexin; oral
4.6
11.1
239
1884
J01DA01
ATC
[U] cefalexin
2.6
11.1
186
1279
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
45.4
11.0
13
*
XG466
NOMESCO Finland
Sleep oxymetry
8.6
10.9
23
29
R52.9
ICD-10 Finland
Pain, unspecified
3.2
10.8
48
171
A02BC02
ATC
pantoprazole; systemic
2.7
10.8
196
1390
J32.1
ICD-10 Finland
Chronic frontal sinusitis
22.6
10.8
15
7
WW500
NOMESCO Finland
Blood transfusion
5.6
10.8
21
40
H04.10
ICD-10 Finland
Dry eye syndrome
3.0
10.8
56
219
UKC02
NOMESCO Finland
Cystoscopy
3.2
10.8
47
166
A03
ICPC
Fever
2.7
10.8
75
343
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.8
10.7
25
56
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
62.7
10.7
12
*
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
5.2
10.7
23
48
A06AD11
ATC
lactulose; oral
3.3
10.7
46
161
J01
ICD-10 Finland
Acute sinusitis
4.1
10.7
31
83
N06AX11
ATC
mirtazapine; oral
2.4
10.6
117
663
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
5.8
10.6
20
37
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
17.0
10.5
16
10
N05CD07
ATC
temazepam; oral
3.6
10.5
38
119
3XA02, ,
NOMESCO Finland
+∞
10.5
10
*
D83.8
ICD-10 Finland
Other common variable immunodeficiencies
+∞
10.5
10
*
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.9
10.5
24
53
A01AB04
ATC
amphotericin B; local oral
5.1
10.5
23
49
DMB10
NOMESCO Finland
Radical maxillary antrotomy
34.1
10.4
13
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.9
10.4
59
242
ZXE00
NOMESCO Finland
One hour or less
2.4
10.4
124
726
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
24.5
10.4
14
6
K92.1
ICD-10 Finland
Melaena
5.4
10.2
21
42
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
10.2
113
638
L04AX01
ATC
azathioprine; systemic
5.1
10.2
22
46
UJF92
NOMESCO Finland
Capsular endoscopy
10.7
10.2
19
19
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.4
10.1
98
521
NF1AA
NOMESCO Finland
Hip X-ray examination
3.8
10.1
33
96
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
3.1
10.0
47
173
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.1
10.0
48
179
J01DC02
ATC
cefuroxime; systemic
4.2
10.0
28
73
M04AA01
ATC
allopurinol; systemic
3.6
9.9
35
108
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.9
9.7
52
206
M35.7
ICD-10 Finland
Hypermobility syndrome
9.7
9.7
19
21
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
8.1
9.6
21
28
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.0
9.6
48
183
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
9.6
123
735
L04AX03
ATC
methotrexate; systemic
3.2
9.6
43
154
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.6
9.6
34
105
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.4
9.5
22
32
R51.80
ICD-10 Finland
Headache
2.6
9.5
70
327
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
5.2
9.5
20
41
SPAT1262
SPAT
Handing over of treatment supplies
2.9
9.5
52
209
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
3.5
9.5
35
111
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
9.4
112
647
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.7
9.4
32
96
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.7
9.4
31
91
C07AB07
ATC
bisoprolol; oral
2.3
9.3
129
793
R51
ICD-10 Finland
Headache
4.0
9.3
28
77
R96
ICPC
Asthma
3.2
9.2
40
140
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.4
9.2
24
59
D64.9
ICD-10 Finland
Anaemia, unspecified
3.5
9.2
34
108
A02BC03
ATC
lansoprazole; oral
2.4
9.1
89
472
E000001, ,
ATC
2.5
9.1
69
326
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.1
9.1
41
147
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
38.1
9.1
11
*
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
2.4
9.1
76
376
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.5
9.1
73
355
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
9.0
45
171
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.8
9.0
21
47
M48.0
ICD-10 Finland
Spinal stenosis
3.1
9.0
41
148
A02BC01
ATC
omeprazole; systemic
2.4
9.0
85
444
L04AA13
ATC
[U] leflunomide
9.1
9.0
18
21
R75
ICPC
Sinusitis acute/chronic
3.9
9.0
28
79
R01AD11
ATC
triamcinolone; nasal
3.2
9.0
39
137
R30.0
ICD-10 Finland
Dysuria
4.4
8.9
23
56
ZXA00
NOMESCO Finland
Right side
2.4
8.9
80
408
L01BA01
ATC
methotrexate; systemic
7.0
8.9
21
32
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
4.2
8.8
24
61
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
3.7
8.8
29
85
GD1CG
NOMESCO Finland
Extensive examination of lungs and pleura with high intensity magnet
51.8
8.7
10
*
M25.5
ICD-10 Finland
Pain in joint
2.2
8.7
114
680
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
6.8
8.7
21
33
R5140
NOMESCO Finland
Monitoring the use of the aid
3.0
8.7
43
163
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
17.0
8.6
13
8
D07AC01
ATC
betamethasone; topical
2.2
8.6
113
674
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.8
8.5
49
201
J01.1
ICD-10 Finland
Acute frontal sinusitis
8.3
8.5
18
23
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.2
8.5
103
595
ZX110
NOMESCO Finland
Intracutaneous
93.0
8.5
9
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
9.0
8.4
17
20
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
7.5
8.4
19
27
WZC00
NOMESCO Finland
Treatment plan or consultation
2.2
8.4
118
722
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
6.9
8.4
20
31
A02BA02
ATC
ranitidine; systemic
2.6
8.3
56
249
G72.9
ICD-10 Finland
Myopathy, unspecified
15.1
8.3
13
9
N06AB04
ATC
citalopram; systemic
2.4
8.3
68
332
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
8.3
43
167
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.0
8.3
24
64
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
4.8
8.3
19
42
Z50.1
ICD-10 Finland
Other physical therapy
3.8
8.2
26
74
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
9.4
8.2
16
18
H65.2
ICD-10 Finland
Chronic serous otitis media
10.5
8.1
15
15
K59.0
ICD-10 Finland
Constipation
4.0
8.1
24
65
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.2
8.1
100
580
H60.9
ICD-10 Finland
Otitis externa, unspecified
3.2
8.1
34
117
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.5
8.0
56
253
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
6.5
8.0
20
33
N05BA04
ATC
oxazepam; oral
2.2
8.0
89
494
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.0
8.0
39
146
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.1
8.0
35
123
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
4.9
8.0
18
39
S01AA01
ATC
chloramphenicol; ophthalmic
4.0
8.0
23
61
R60.9
ICD-10 Finland
Oedema, unspecified
4.0
8.0
23
61
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
3.4
8.0
30
96
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
13.6
8.0
13
10
N02AC04
ATC
dextropropoxyphene; oral
7.4
7.9
18
26
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.5
7.9
28
86
R02
ICPC
Shortness of breath/dyspnoea
2.7
7.9
46
190
Z3229
NOMESCO Finland
Other healthcare associate professional
3.2
7.9
33
113
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.3
7.9
20
34
J01EA01
ATC
trimethoprim; systemic
2.2
7.9
86
474
R06AX26
ATC
fexofenadine; oral
3.2
7.8
32
108
XCK00
NOMESCO Finland
Perimetry
4.0
7.8
23
62
ZY010
NOMESCO Finland
Hospital outpatient
3.5
7.8
28
87
N03AX09
ATC
lamotrigine; oral
3.5
7.8
28
87
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.5
7.8
28
87
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
3.5
7.8
28
87
A10BH01
ATC
sitagliptin; oral
3.3
7.8
31
103
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
7.7
49
211
M01AH01
ATC
celecoxib; oral
2.5
7.7
58
271
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.5
7.7
59
278
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.7
7.7
47
199
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
10.5
7.6
14
14
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
25.9
7.6
10
*
ZX121
NOMESCO Finland
Central venous catheter
25.9
7.6
10
*
UDM02
NOMESCO Finland
Sinoscopy
7.5
7.6
17
24
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.5
7.6
19
45
S97
ICPC
Chronic ulcer skin
3.6
7.6
26
78
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.2
7.6
32
110
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.6
7.5
51
227
SBA00
NOMESCO Finland
Microbiological examinations
8.0
7.5
16
21
J01DA08
ATC
[U] cefaclor
2.7
7.5
43
176
Z71.8
ICD-10 Finland
Other specified counselling
2.1
7.4
116
730
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.8
7.4
39
152
WX882
NOMESCO Finland
High dependency care
6.6
7.4
18
29
C09CA06
ATC
candesartan; oral
2.2
7.4
75
400
R4120
NOMESCO Finland
Occupational therapy
3.2
7.4
30
101
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
7.3
48
210
2790C
ICD-9 Finland
Disorders involving the immune mechanism, Deficiency of humoral immunity[DEFICIENTIA IMMUNOGLOBULINI ALIA]
+∞
7.3
7
*
SPAT1229
SPAT
Assessment of need for aid
3.6
7.3
25
75
J11.1
ICD-10 Finland
Influenza with other respiratory manifestations, virus not identified
5.9
7.2
19
34
ZXH09, ,
SPAT
6.4
7.2
18
30
WX722
NOMESCO Finland
PEEP
4.3
7.2
19
47
ZXA05
NOMESCO Finland
Left side
2.3
7.2
70
366
318
Kela drug reimbursment
Teriparatide
31.0
7.2
9
*
TEA00
NOMESCO Finland
Biopsy of lip
20.7
7.2
10
5
K07.60
ICD-10 Finland
Snapping jaw
3.3
7.1
28
92
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
7.1
63
317
H02BX01
ATC
methylprednisolone, combinations; systemic
4.6
7.1
17
39
E87.6
ICD-10 Finland
Hypokalaemia
4.6
7.1
17
39
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
5.8
7.1
19
35
R51.81
ICD-10 Finland
Facial pain NOS
5.8
7.1
19
35
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.9
7.1
21
57
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
6.7
7.1
17
27
ZXD05
NOMESCO Finland
Urgent procedure
2.1
7.0
93
548
G47.3
ICD-10 Finland
Sleep apnoea
2.2
7.0
72
384
XLA10, ,
NOMESCO Finland
4.2
7.0
19
48
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
7.9
7.0
15
20
R20.2
ICD-10 Finland
Paraesthesia of skin
3.1
7.0
31
110
J30.3
ICD-10 Finland
Other allergic rhinitis
4.0
7.0
20
53
H65.3
ICD-10 Finland
Chronic mucoid otitis media
6.4
6.9
17
28
JN4AD
NOMESCO Finland
Body CT examination
2.7
6.8
38
153
B29
ICPC
Lymph/immune mech sympt/complt other
17.3
6.8
10
6
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
17.3
6.8
10
6
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
17.3
6.8
10
6
C08DA01
ATC
verapamil; systemic
3.9
6.8
20
54
A04AA01
ATC
ondansetron; systemic, rectal
3.0
6.8
31
112
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
5.8
6.7
18
33
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
6.7
124
821
X58
ICD-10 Finland
Exposure to other specified factors
2.4
6.7
53
253
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.2
6.7
65
339
L28
ICPC
Limited function/disability (L)
2.3
6.6
55
268
UDC00
NOMESCO Finland
Ear microscopy
3.2
6.6
27
91
M01AH02
ATC
rofecoxib; oral
2.6
6.6
40
168
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.2
6.6
70
378
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.7
6.6
21
60
SAA04
NOMESCO Finland
Special examination of mouth
3.6
6.6
22
65
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
6.6
89
527
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
6.0
6.6
17
30
G44.2
ICD-10 Finland
Tension-type headache
2.4
6.6
53
255
R35
ICD-10 Finland
Polyuria
3.3
6.6
26
86
C05AA08
ATC
fluocortolone; rectal, topical
2.5
6.5
44
195
D07AD01
ATC
clobetasol; topical
2.3
6.5
55
270
J01DA09
ATC
[U] cefadroxil
2.1
6.5
80
457
G50.1
ICD-10 Finland
Atypical facial pain
7.7
6.5
14
19
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
7.7
6.5
14
19
R49.01
ICD-10 Finland
Functional dysphonia
3.9
6.5
19
51
ZXD20
NOMESCO Finland
Day surgery
2.5
6.5
45
202
N30.0
ICD-10 Finland
Acute cystitis
2.3
6.5
58
292
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
6.5
80
458
E23.03
ICD-10 Finland
Lack of ACTH
71.5
6.5
7
*
DPA20
NOMESCO Finland
Trephine of frontal sinus
71.5
6.5
7
*
H02AA02
ATC
fludrocortisone; oral
71.5
6.5
7
*
C10AC01
ATC
colestyramine; oral
5.4
6.5
18
35
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
3.5
6.4
23
71
R25.2
ICD-10 Finland
Cramp and spasm
6.2
6.4
16
27
M03BX01
ATC
baclofen; systemic
6.2
6.4
16
27
Z01.7
ICD-10 Finland
Laboratory examination
2.3
6.4
58
293
R78
ICPC
Acute bronchitis/bronchiolitis
8.5
6.4
13
16
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
11.4
6.4
11
10
A28
ICPC
Limited function/disability NOS
2.5
6.3
43
191
J01MA01
ATC
ofloxacin; systemic
3.1
6.3
28
99
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
6.3
28
99
B03BA03
ATC
hydroxocobalamin; parenteral
3.9
6.3
19
52
J96.0
ICD-10 Finland
Acute respiratory failure
18.6
6.3
9
5
XA800
NOMESCO Finland
Neuropsychological investigation
3.5
6.3
22
67
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.0
6.3
29
105
N06AX16
ATC
venlafaxine; oral
2.3
6.3
55
274
WX872
NOMESCO Finland
Intensive care
4.2
6.3
17
43
D84.1
ICD-10 Finland
Defects in the complement system
+∞
6.3
6
*
4AA24, ,
NOMESCO Finland
+∞
6.3
6
*
D84.19
ICD-10 Finland
Unspecified defect in the complement system
+∞
6.3
6
*
R50.1
ICD-10 Finland
Persistent fever
+∞
6.3
6
*
D81.1
ICD-10 Finland
Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
+∞
6.3
6
*
D02AE01
ATC
carbamide; topical
3.2
6.3
25
83
H05AA02
ATC
teriparatide; parenteral
27.4
6.3
8
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.1
6.3
27
94
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.6
6.2
38
160
K59.1
ICD-10 Finland
Functional diarrhoea
3.3
6.2
24
78
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
8.0
6.2
13
17
M01AE03
ATC
ketoprofen; systemic, rectal
2.0
6.2
99
620
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.8
6.2
33
130
JN6AD
NOMESCO Finland
CT of torso and neck
8.9
6.1
12
14
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
7.0
6.1
14
21
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.0
6.1
14
21
M05BB03
ATC
alendronic acid and colecalciferol; oral
7.0
6.1
14
21
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.8
6.1
16
29
S01GX05
ATC
lodoxamide; ophthalmic
10.4
6.1
11
11
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.1
6.1
17
44
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.9
6.1
126
859
N06AB10
ATC
escitalopram; oral
2.1
6.1
74
420
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.7
6.0
35
144
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
3.7
6.0
19
54
M05BA07
ATC
risedronic acid; oral
7.5
6.0
13
18

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
103
24
70.77
180.73
3.0
1.3
—
—
—
0
0
99
24
66.31
171.80
2.6
1.3
2.18
3.13
g/l
1.36
80
19
162
163
25.02
160.50
4.5
1.6
1.09
1.38
g/l
0.78
154
153
84
22
56.13
141.99
2.2
1.9
1353.39
1382.24
e6/l
0.04
75
17
70
16
59.67
121.34
1.8
2.1
43.39
32.64
%
1.49
60
16
62
21
38.55
96.35
2.0
1.8
430.63
733.20
e6/l
0.79
49
15
127
183
12.70
93.39
2.0
1.3
88.00
332.19
u/ml
1.01
114
176
53
31
21.26
66.22
3.9
2.8
—
—
—
0
0
186
578
8.95
64.71
4.4
1.4
1.73
2.28
g/l
4.74
157
356
191
777
6.62
44.53
20.8
6.5
—
—
—
0
0
99
264
5.46
36.82
3.1
1.6
—
—
—
0
0
148
556
4.90
35.81
9.7
3.9
—
—
—
0
0
230
1257
8.65
34.21
23.7
6.5
1.92
1.98
e9/l
0.28
230
1110
102
296
5.05
33.95
2.4
1.5
—
—
—
0
0
237
1365
10.05
32.27
28.5
10.5
4.03
3.88
e9/l
0.59
232
1177
88
244
4.96
30.61
3.7
2.2
311.27
371.80
nmol/l
1.78
79
230
99
314
4.49
28.82
3.9
2.0
—
—
—
0
0
108
370
4.30
28.26
1.9
1.4
454.00
497.08
titre
0.17
20
89
106
369
4.18
26.94
4.0
2.4
12.55
13.70
umol/l
0.82
100
348
25
0
+∞
26.51
1.5
0.0
2.07
—
iu/ml
—
16
0
43
75
6.68
24.57
1.5
1.4
—
—
—
0
0
93
319
3.99
23.72
4.0
2.4
20.33
23.29
%
1.19
88
302
21
0
+∞
22.20
1.8
0.0
0.72
—
iu/ml
—
13
0
69
204
4.25
21.41
9.6
5.1
0.57
0.62
%
0.08
42
62
191
1100
3.84
21.06
17.6
7.6
1.22
1.22
mmol/l
0.02
173
963
120
531
3.36
20.13
4.0
2.4
3.62
2.79
mg/l
2.52
112
465
67
209
3.98
19.15
10.6
5.4
0.08
0.10
%
0.17
40
59
53
140
4.51
18.91
2.4
2.3
—
—
—
0
0
69
222
3.88
18.85
10.6
5.2
1.02
0.87
%
0.18
42
73
184
1087
3.42
18.34
5.2
2.7
82.33
77.59
nmol/l
1.46
179
988
142
728
3.11
18.01
15.4
6.9
—
—
—
0
0
29
23
14.05
17.12
1.5
1.3
0.57
0.45
u/ml
0.08
18
12
114
529
3.07
17.05
2.4
2.0
—
—
—
0
0
34
68
5.61
16.72
2.0
1.5
331.85
286.85
ug/g
0.50
20
38
64
211
3.70
16.71
11.0
5.8
0.00
0.04
%
0.80
36
53
118
566
3.00
16.52
4.1
3.1
666.42
699.15
ng/l
0.08
104
472
24
13
20.19
16.35
2.4
1.2
—
—
—
0
0
162
938
2.95
15.77
15.6
9.9
1.12
1.14
inr
0.27
135
759
55
177
3.68
14.77
4.5
2.7
77.63
71.43
e9/l
0.57
49
126
110
536
2.83
14.58
3.2
1.9
1.30
1.23
mg/l
0.07
87
419
83
350
3.02
14.32
2.5
2.6
240.41
108.75
ug/g
1.00
64
283
25
44
6.18
13.96
5.9
3.7
3.61
4.32
e9/l
0.71
25
44
78
322
3.04
13.93
1.4
1.2
—
—
—
0
0
29
64
4.98
12.71
7.5
3.3
57.34
57.97
%
0.07
29
64
136
783
2.56
12.38
6.2
3.5
21.34
109.29
ng/l
0.57
96
505
113
596
2.59
12.37
14.0
5.2
—
—
—
0
0
116
626
2.55
12.03
2.1
1.6
22.47
21.73
nmol/l
0.20
107
530
72
310
2.83
11.70
4.1
2.9
4.49
5.18
e9/l
0.39
62
273
42
131
3.64
11.70
1.9
1.6
7.91
3.74
iu/ml
0.48
15
31
35
99
3.93
11.19
6.2
10.0
—
—
—
0
0
162
1044
2.48
11.13
6.0
3.2
6.06
6.22
ph
1.04
87
586
122
693
2.44
11.11
9.0
3.9
7.40
7.39
ph
0.59
84
485
128
743
2.43
11.10
4.1
2.4
—
—
—
0
0
43
142
3.43
10.96
1.7
1.2
—
—
—
0
0
165
1083
2.45
10.73
32.2
10.5
0.00
0.00
e9/l
0.58
148
876
55
214
3.00
10.67
11.7
11.4
1.51
0.94
mmol/l
0.31
47
183
65
278
2.79
10.60
1.6
1.4
—
—
—
0
0
173
1166
2.47
10.51
5.5
3.1
114.26
90.79
ug/l
0.91
167
1095
55
216
2.97
10.49
12.0
11.4
7.42
7.42
ph
0.06
30
114
152
970
2.38
10.42
2.8
2.0
94.64
98.51
pmol/l
0.45
89
489
39
125
3.50
10.39
3.5
2.2
0.00
0.00
estimate
—
8
46
25
58
4.67
10.30
1.3
1.6
—
—
—
0
0
30
81
4.06
10.20
5.6
4.5
259.29
435.61
mg/l
0.35
17
33
68
306
2.66
10.00
2.2
1.7
1348.94
1167.10
nmol/l
0.84
56
220
19
20
10.16
9.95
3.3
3.3
—
—
—
0
0
34
103
3.65
9.84
12.5
4.7
—
—
—
0
0
24
58
4.46
9.40
3.7
2.7
2.50
1.59
index
0.30
12
36
30
86
3.82
9.39
2.6
2.0
1.46
1.51
g/l
0.09
24
79
58
251
2.69
9.15
2.7
1.4
—
—
—
0
0
32
100
3.51
8.83
1.4
1.2
—
—
—
0
0
110
646
2.23
8.76
8.0
3.1
0.34
0.39
e6/l
0.13
94
451
99
559
2.25
8.66
3.2
2.9
326.79
327.60
umol/l
0.03
92
496
181
1301
2.31
8.66
7.4
3.6
0.00
0.01
estimate
0.50
42
248
179
1281
2.30
8.65
7.4
3.5
0.00
0.00
estimate
0.50
41
263
180
1293
2.30
8.59
7.3
3.6
0.00
0.00
estimate
-0.00
42
266
26
72
3.90
8.53
17.9
9.5
—
—
—
0
0
22
54
4.36
8.44
2.7
2.1
126.29
131.15
g/l
0.28
14
40
68
331
2.43
8.35
2.1
1.5
—
—
—
0
0
84
454
2.26
8.08
2.2
1.6
—
—
—
0
0
31
102
3.32
7.89
1.4
1.5
—
—
—
0
0
134
879
2.09
7.78
9.4
4.0
14.20
63.81
e6/l
3.18
104
587
51
224
2.59
7.74
3.3
2.0
0.00
0.00
estimate
—
8
55
113
698
2.10
7.68
7.8
3.5
0.00
0.00
estimate
0.50
39
253
18
41
4.64
7.55
1.1
1.1
6.88
0.99
u/ml
0.61
12
24
16
22
7.68
7.31
1.1
1.8
—
—
—
0
0
49
217
2.55
7.29
21.1
4.8
7.36
7.39
ph
1.42
30
126
45
193
2.61
7.14
29.6
10.0
—
—
—
0
0
117
750
2.02
7.04
8.3
3.2
11.78
52.22
e6/l
2.61
98
556
58
283
2.35
6.99
24.5
7.8
102.41
104.54
mmol/l
1.94
58
283
17
29
6.20
6.73
1.4
1.4
—
—
—
0
0
17
29
6.20
6.73
1.4
1.4
—
—
—
0
0
17
29
6.20
6.73
1.4
1.4
—
—
—
0
0
17
29
6.20
6.73
1.4
1.4
—
—
—
0
0
81
461
2.10
6.67
1.5
1.4
2.79
10.40
u/ml
1.98
24
190
44
197
2.49
6.37
1.9
1.2
31.83
150.64
u/ml
3.68
20
72
19
52
3.86
6.32
1.4
1.7
—
—
—
0
0
9
5
18.57
6.31
2.4
2.0
79.22
106.00
ug/l
—
9
5
46
213
2.41
6.19
2.0
1.4
—
—
—
0
0
16
39
4.31
6.18
5.7
2.9
—
—
—
0
0
24
79
3.25
6.10
1.1
1.1
—
—
—
0
0
44
203
2.41
5.96
1.9
1.4
—
—
—
0
0
15
27
5.83
5.78
4.9
2.8
—
—
—
0
0
19
56
3.58
5.70
5.3
2.8
7.42
7.41
ph
0.47
19
56
82
493
1.97
5.69
1.6
1.4
13.15
29.08
iu/ml
2.50
22
160
15
28
5.62
5.63
1.8
1.4
—
—
—
0
0
17
47
3.80
5.58
1.1
1.1
0.48
0.97
u/ml
—
8
20
15
29
5.42
5.48
1.1
1.4
—
—
nmol/l
—
0
0
32
133
2.61
5.38
29.3
4.7
25.24
24.57
mmol/l
0.44
32
133
14
26
5.63
5.30
1.9
1.3
—
—
—
0
0
72
423
1.97
5.29
4.0
3.5
139.24
331.00
ng/l
0.74
38
292
19
59
3.40
5.28
1.2
1.2
0.75
2.52
u/ml
—
9
39
251
2303
4.31
5.24
57.9
14.0
17.28
21.88
mg/l
2.79
239
1844
13
23
5.89
5.13
3.6
1.5
0.68
0.46
mmol/l
0.06
13
23
14
28
5.22
5.02
1.7
2.0
18.81
32.19
ng/l
0.51
14
28
16
46
3.64
4.98
1.9
1.2
68.57
25.43
iu/ml
—
7
7
15
33
4.76
4.95
1.0
1.1
1.86
2.06
u/ml
—
7
16
15
33
4.76
4.95
1.1
1.1
12.76
7.37
u/ml
—
9
16
29
120
2.60
4.92
29.9
3.3
0.67
0.61
%
0.35
29
120
16
38
4.42
4.91
4.7
2.3
92.58
91.49
%
0.40
16
38
15
42
3.73
4.84
1.7
1.2
—
—
—
0
0
146
1094
1.77
4.80
4.5
2.8
—
—
estimate
—
0
0
14
30
4.87
4.75
2.5
1.5
1.13
0.94
%
0.47
14
14
117
827
1.76
4.67
3.5
3.1
2.34
2.36
mmol/l
1.79
106
755
11
18
6.33
4.65
2.0
1.0
—
—
—
0
0
15
36
4.36
4.60
1.3
1.9
—
—
—
0
0
16
49
3.42
4.55
1.1
1.1
10.35
2.76
u/ml
—
10
28
12
23
5.42
4.51
1.4
1.3
—
—
—
0
0
72
444
1.86
4.50
2.0
1.7
487.70
31200448.73
pmol/l
0.50
64
375
11
19
6.00
4.49
1.2
1.1
—
—
—
0
0
199
1651
1.90
4.49
5.7
3.5
64.87
42.16
u/l
1.67
193
1577
15
37
4.24
4.48
1.4
1.3
—
—
—
0
0
17
55
3.24
4.45
2.2
1.3
31995.91
18454.59
e6/l
0.21
11
37
13
28
4.83
4.43
1.8
1.0
—
—
—
0
0
11
20
5.69
4.34
1.0
1.1
31.22
33.97
mg/l
0.14
11
15
10
17
6.07
4.17
1.3
1.1
—
—
—
0
0
18
63
3.00
4.15
4.7
4.1
8.67
8.92
kpa
0.28
18
63
18
64
2.95
4.05
1.7
1.3
—
—
—
0
0
17
59
3.01
3.98
46.4
2.8
69.02
63.11
%
0.62
17
59
16
54
3.09
3.92
3.1
3.7
3.63
1.89
ratio
0.31
11
25
17
60
2.96
3.87
1.1
1.1
—
—
—
0
0
19
72
2.77
3.82
2.6
1.8
2.01
4.20
iu/l
—
9
33
14
40
3.64
3.67
4.6
2.7
16.81
16.77
%
0.02
14
40
15
51
3.06
3.64
1.6
3.3
3.96
6.70
pmol/l
1.35
15
51
92
643
1.67
3.63
1.5
1.4
0.60
1.56
u/ml
1.72
26
180
29
139
2.22
3.60
1.2
1.1
—
—
—
0
0
10
21
4.91
3.59
1.2
1.4
—
—
—
0
0
9
17
5.44
3.54
1.1
1.3
—
—
—
0
0
13
37
3.64
3.45
1.7
1.2
—
—
—
0
0
11
27
4.21
3.43
3.5
1.6
30.91
33.22
pg
0.62
11
27
126
965
1.60
3.39
2.7
2.0
—
—
—
0
0
7
10
7.16
3.38
3.0
3.0
0.59
0.63
mmol/l
—
7
10
7
10
7.16
3.38
1.0
2.6
—
—
—
0
0
16
60
2.78
3.29
1.1
1.1
—
—
—
0
0
14
49
2.96
3.24
1.5
2.9
30.93
36.26
umol/l
0.57
14
43
7
11
6.50
3.20
1.3
1.1
183.43
175.42
mmol/24h
—
7
11
42
242
1.88
3.19
3.8
2.6
46.54
27.08
u/l
0.89
37
195
251
2368
3.21
3.09
38.1
12.2
—
—
—
0
0
49
300
1.78
3.07
1.9
1.8
—
—
—
0
0
6
8
7.64
3.07
1.0
1.0
2917.33
1714.38
miu/ml
—
6
8
58
373
1.72
3.07
6.8
3.1
2.80
2.71
e6/l
0.03
32
162
210
1844
1.75
3.05
7.5
4.5
14.81
14.64
pmol/l
0.44
200
1710
23
109
2.22
2.95
1.8
2.2
1525.08
5451.06
u/l
—
9
40
247
2298
2.76
2.94
53.9
15.9
139.45
139.77
mmol/l
1.47
247
2258
11
32
3.54
2.93
1.4
1.3
—
—
—
0
0
7
13
5.50
2.89
1.7
2.1
—
—
—
0
0
7
13
5.50
2.89
1.6
1.5
6.93
3.29
mg/l
—
7
13
247
2302
2.71
2.85
54.1
15.9
3.91
3.94
mmol/l
0.76
247
2253
67
458
1.63
2.80
3.4
2.4
2.43
2.45
mmol/l
1.09
60
413
10
29
3.54
2.72
1.4
1.2
—
—
—
0
0
8
19
4.31
2.70
1.0
1.0
—
—
—
0
0
12
41
3.02
2.66
6.0
2.8
8.93
8.91
kpa
0.01
12
41
12
41
3.02
2.66
6.1
2.8
4.75
5.01
kpa
0.53
12
41
7
15
4.76
2.61
1.3
1.1
—
—
—
0
0
9
25
3.69
2.60
1.8
2.2
23.13
27.00
nmol/l
—
9
20
5
7
7.26
2.56
2.6
1.7
—
—
—
0
0
6
11
5.55
2.55
6.5
2.9
0.33
0.73
index
—
6
11
11
37
3.06
2.52
2.9
1.7
5.37
5.31
mmol/24h
0.02
11
31
253
2421
3.32
2.52
55.1
17.6
73.73
71.29
umol/l
0.50
253
2400
10
32
3.21
2.46
1.5
1.9
—
—
—
0
0
10
33
3.11
2.38
3.7
2.0
1.95
1.56
mmol/l
—
10
33
5
8
6.35
2.38
2.6
3.6
37.50
47.25
%
—
5
8
5
8
6.35
2.38
2.2
1.4
67.40
54.82
ng/l
—
5
8
32
188
1.80
2.30
9.1
3.5
—
—
—
0
0
120
965
1.46
2.30
7.7
3.4
0.06
0.02
estimate
0.25
35
225
76
559
1.51
2.27
6.7
3.4
1.02
1.02
kg/l
0.22
47
367
7
18
3.97
2.27
1.3
1.1
—
—
—
0
0
7
19
3.76
2.16
1.0
1.2
—
—
—
0
0
6
14
4.36
2.16
1.5
1.6
—
—
—
0
0
37
233
1.69
2.11
3.4
4.3
3.88
26.18
ug/l
0.63
28
188
48
324
1.59
2.09
1.7
1.5
—
—
—
0
0
5
10
5.07
2.08
1.4
1.0
—
—
—
0
0
16
76
2.18
2.07
1.2
1.2
—
—
—
0
0
7
20
3.57
2.07
1.0
1.5
—
—
—
0
0
6
15
4.07
2.05
1.0
1.4
3.67
0.50
u/field
—
6
8
6
15
4.07
2.05
1.0
1.3
133.83
101.80
pmol/l
—
6
15
78
999
0.69
2.05
3.1
3.0
—
—
—
0
0
11
44
2.57
2.04
1.1
1.1
—
—
—
0
0
9
32
2.88
2.02
1.0
1.3
—
—
—
0
0
9
32
2.88
2.02
1.0
1.1
—
—
—
0
0
9
32
2.88
2.02
1.3
1.1
—
—
—
0
0
232
2157
1.75
1.98
8.7
5.5
1.76
1.85
mu/l
0.59
227
2026
35
222
1.67
1.95
1.2
1.2
—
—
—
0
0
9
34
2.71
1.88
2.0
1.4
—
—
—
0
0
6
17
3.59
1.85
2.3
2.1
9.12
10.88
umol/l
—
6
17
5
12
4.23
1.83
1.2
5.2
1177.20
1384.67
mg
—
5
12
8
30
2.72
1.74
1.1
1.1
—
—
—
0
0
5
13
3.90
1.72
1.4
1.5
—
—
—
0
0
96
773
1.39
1.71
4.2
3.4
7.26
7.70
mmol/l
0.43
90
664
12
55
2.24
1.70
64.7
2.1
64.11
62.30
%
0.10
12
55
6
19
3.21
1.67
6.5
2.4
22.83
12.55
index
—
6
11
5
14
3.62
1.62
1.4
1.1
—
—
g/l
—
0
0
6
20
3.05
1.59
1.3
1.1
—
—
—
0
0
15
266
0.54
1.55
1.3
1.4
—
—
—
0
0
6
21
2.90
1.51
1.7
1.0
—
—
—
0
0
88
717
1.35
1.42
6.0
3.1
0.00
0.01
estimate
0.74
33
215
11
54
2.08
1.35
1.4
2.0
—
—
—
0
0
6
24
2.53
1.31
1.3
2.6
1.78
2.91
nmol/l
—
6
24
6
26
2.34
1.19
4.2
1.3
428.17
232.62
mu/l
—
6
21
10
51
2.00
1.12
1.0
1.1
—
—
—
0
0
83
700
1.27
1.01
4.8
4.0
12.55
8.10
mg/mmol
0.30
54
422
42
322
1.36
1.00
1.4
1.2
—
—
—
0
0
9
50
1.83
0.97
2.3
1.9
0.91
0.91
nmol/l
—
9
42
81
686
1.26
0.95
4.3
3.4
46.70
51.95
mg/l
0.08
52
430
19
276
0.66
0.93
2.1
1.8
—
—
—
0
0
27
195
1.43
0.91
3.6
2.0
5.95
6.15
ph
0.68
19
122
8
42
1.93
0.89
1.1
1.2
—
—
—
0
0
228
2189
1.36
0.81
5.8
4.8
5.93
5.80
mmol/l
0.59
217
2050
21
149
1.45
0.78
1.0
1.1
—
—
—
0
0
5
25
2.02
0.73
1.0
3.6
23.28
32.65
mu/l
—
5
25
116
1052
1.19
0.66
2.1
2.0
1.39
1.38
mmol/l
0.02
100
896
9
63
1.44
0.53
1.4
1.2
—
—
—
0
0
15
110
1.39
0.50
1.8
1.8
—
—
—
0
0
80
728
1.14
0.42
1.8
1.5
—
—
—
0
0
219
2129
1.19
0.42
7.6
5.9
38.82
38.51
mmol/mol
0.20
212
2017
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
6
41
1.47
0.36
2.7
2.1
—
—
—
0
0
14
108
1.31
0.36
2.8
3.2
1.02
1.02
ratio
0.05
14
102
13
102
1.29
0.30
2.7
2.3
—
—
—
0
0
12
98
1.24
0.21
1.8
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
3.1
—
502.40
—
0
5
0
10
0.00
0.21
0.0
3.5
—
698.20
—
0
5
20
174
1.16
0.20
1.5
1.3
—
—
—
0
0
7
59
1.19
0.18
1.0
1.1
—
—
—
0
0
253
2514
1.33
0.17
70.8
21.9
256.45
257.71
e9/l
0.09
253
2476
9
83
1.09
0.15
1.7
1.1
1.63
1.58
g/l
—
9
83
204
2012
1.07
0.13
52.0
17.5
13.94
13.43
%
4.85
204
1995
12
137
0.87
0.12
2.5
1.8
—
—
—
0
0
13
114
1.15
0.12
1.8
2.4
—
—
—
0
0
11
95
1.16
0.12
2.0
2.0
—
—
—
0
0
218
2156
1.07
0.12
4.5
4.2
1.39
1.26
mmol/l
1.66
206
2019
5
45
1.11
0.10
2.4
2.8
3.42
87.55
u/ml
—
5
45
5
47
1.07
0.09
3.0
3.8
1.44
1.33
mmol/l
—
5
47
41
391
1.06
0.08
3.9
4.7
1.44
1.72
ug/l
0.59
41
353
253
2517
1.27
0.08
71.2
22.0
131.17
135.69
g/l
4.67
253
2496
253
2516
1.29
0.08
70.2
21.8
30.26
30.25
pg
0.05
253
2496
253
2516
1.29
0.08
73.7
22.2
39.69
40.59
%
2.62
253
2495
253
2515
1.31
0.08
70.2
21.8
91.17
90.75
fl
0.70
253
2495
7
66
1.06
0.08
2.0
2.9
—
—
—
0
0
6
70
0.85
0.07
1.3
1.6
—
—
—
0
0
9
88
1.02
0.07
1.7
1.2
0.82
0.89
g/l
—
9
88
14
129
1.09
0.05
1.1
1.1
—
—
—
0
0
13
122
1.07
0.02
1.8
2.3
—
—
—
0
0
228
2271
1.03
0.02
5.5
4.9
1.58
1.51
mmol/l
1.42
217
2135
13
123
1.06
0.01
1.8
2.3
—
—
—
0
0
13
123
1.06
0.01
1.8
2.3
—
—
—
0
0
228
2278
1.01
0.00
5.5
5.0
4.84
4.77
mmol/l
0.46
217
2152
230
2297
1.01
0.00
6.1
5.7
2.75
2.82
mmol/l
0.50
218
2169
12
123
0.97
0.00
1.8
2.0
—
—
—
0
0
6
68
0.88
-0.00
1.3
1.5
—
—
—
0
0
8
87
0.92
-0.00
1.9
3.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
1.1
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
51.20
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint D3_DEF_IGG and mortality.

Females

Parameter HR [95% CI] p-value
D3_DEF_IGG 2.525 [1.85, 3.45] < 0.001
Birth year 1.0 [0.99, 1.01] 0.938

During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 613 females with D3_DEF_IGG died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_DEF_IGG.

N-year risk Females Males
1 0.284% No data
5 1.813% No data
10 4.498% No data
15 8.646% No data
20 14.401% No data

Relationships between endpoints

↥

Index endpoint: D3_DEF_IGG – Selective deficiency of immunoglobulin G [IgG] subclasses

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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