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Arthropathy in Crohn disease

DOID EFO Endpoint Browser PheWeb

CROHN_ARTHR

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

426

4. Check minimum number of events

None

426

5. Include endpoints

None

426

6. Filter based on genotype QC (FinnGen only)

390

Control definitions (FinnGen only)

Control exclude
PSOR_ENTE_ARTHR

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1448 820 623
Only index persons 1391 801 590
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 45.47 45.71 45.14
Only index persons 45.12 45.60 44.46

-FinnGen-

Key figures

All Female Male
Number of individuals 390 245 145
Unadjusted period prevalence (%) 0.08 0.09 0.07
Median age at first event (years) 44.57 43.65 46.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
400
Matched controls
4000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A07EC01
ATC
sulfasalazine; oral, rectal
41.0
316.5
237
137
A07EA06
ATC
budesonide; oral, local oral
48.6
314.2
209
88
K50.8
ICD-10 Finland
Other Crohn disease
230.1
307.7
257
31
A07EC02
ATC
mesalazine; oral, rectal
60.7
307.7
251
108
K50.9
ICD-10 Finland
Crohn disease, unspecified
200.3
307.7
244
31
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
307.7
348
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
180.1
307.7
325
94
L04AX01
ATC
azathioprine; systemic
88.5
307.7
239
66
K50.0
ICD-10 Finland
Crohn disease of small intestine
140.0
307.7
195
27
K50.1
ICD-10 Finland
Crohn disease of large intestine
202.2
307.7
191
18
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
180.1
300.7
148
13
L04AX03
ATC
methotrexate; systemic
27.0
253.4
228
187
L04AB04
ATC
adalimumab; parenteral
60.6
230.6
134
33
UJF32
NOMESCO Finland
Coloscopy
22.1
205.7
313
560
UJF30
NOMESCO Finland
Ileoscopy through colon
18.2
190.1
203
214
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
13.8
145.0
174
211
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
25.8
137.7
103
53
L01BA01
ATC
methotrexate; systemic
33.9
132.2
88
33
UJF92
NOMESCO Finland
Capsular endoscopy
34.0
126.7
84
31
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
15.3
123.9
126
117
M07.4
ICD-10 Finland
Arthropathy in Crohn disease [regional enteritis]
+∞
123.5
112
*
L01BB02
ATC
mercaptopurine; oral
46.9
116.7
70
18
H02AB06
ATC
prednisolone; systemic
14.0
100.2
349
1315
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
12.2
93.7
107
116
ZX120
NOMESCO Finland
Intravenous
10.0
93.7
130
183
A07EA02
ATC
hydrocortisone; rectal
25.7
89.6
65
30
K51.5
ICD-10 Finland
Left sided colitis
17.9
85.8
74
50
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.8
81.2
243
746
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
19.6
80.6
66
40
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
18.5
75.1
63
40
M45
ICD-10 Finland
Ankylosing spondylitis
16.9
70.5
62
43
C10AC01
ATC
colestyramine; oral
15.1
66.3
62
48
H02AB07
ATC
prednisone; oral
6.8
66.2
133
274
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.5
64.4
212
678
K50
ICD-10 Finland
Crohn disease [regional enteritis]
126.6
60.9
64
6
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
19.1
60.1
49
29
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
234.5
59.8
60
*
M13.9
ICD-10 Finland
Arthritis, unspecified
8.1
58.9
91
141
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
27.7
57.6
40
16
K51.8
ICD-10 Finland
Other ulcerative colitis
18.9
57.4
47
28
J01MA02
ATC
ciprofloxacin; systemic
5.1
57.1
248
970
L88
ICPC
Rheumatoid/seropositive arthritis
11.8
55.1
60
59
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
72.0
49.7
56
9
L04AC05
ATC
ustekinumab; parenteral
145.7
49.0
51
*
P01AB01
ATC
metronidazole; oral, rectal
4.6
47.4
266
1211
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
9.7
47.2
59
70
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
139.2
46.9
49
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.6
46.7
161
512
256, ,
Kela drug reimbursment
259.1
46.0
46
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
7.0
45.7
78
133
N02AX02
ATC
tramadol; systemic, rectal
4.3
44.7
255
1159
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
477.0
44.1
43
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
14.7
43.1
40
30
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
39.9
255
1223
L40.5
ICD-10 Finland
Arthropathic psoriasis
88.8
36.6
40
5
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
13.1
36.4
36
30
L04AA13
ATC
[U] leflunomide
14.9
36.1
33
24
D94
ICPC
Chronic enteritis/ulcerative colitis
48.0
35.8
43
10
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
9.7
35.2
43
49
L40.0
ICD-10 Finland
Psoriasis vulgaris
8.5
34.3
47
62
K60.3
ICD-10 Finland
Anal fistula
12.7
33.8
34
29
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
11.5
33.6
36
34
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
41.8
30.8
38
10
L04AB02
ATC
infliximab; parenteral
49.3
30.2
36
8
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.7
27.9
74
186
WX002
NOMESCO Finland
Sedation and analgesia
3.6
27.5
114
395
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.6
27.4
75
193
3042, ,
Kela drug reimbursment
77.8
26.1
29
*
253, ,
Kela drug reimbursment
77.8
26.1
29
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
6.4
26.0
46
80
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
32.5
25.4
33
11
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.0
25.3
215
1126
M09.1*K50.9
ICD-10 Finland
Juvenile arthritis in Crohn's disease [regional enteritis]
+∞
25.3
24
*
WVA20
NOMESCO Finland
Medicine administration
7.4
24.6
37
54
B03BA03
ATC
hydroxocobalamin; parenteral
6.7
24.6
41
67
H02AB09
ATC
hydrocortisone; systemic
9.5
24.5
30
34
JF1BD
NOMESCO Finland
Very extensive small bowel CT
60.0
24.4
28
5
M07.3
ICD-10 Finland
Other psoriatic arthropathies
254.6
23.9
24
*
A02BC02
ATC
pantoprazole; systemic
3.4
23.5
317
2104
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
23.1
86
275
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.1
23.0
128
526
4AB02, ,
NOMESCO Finland
88.7
22.9
25
*
M01AH01
ATC
celecoxib; oral
3.3
22.4
102
371
M074, L405,
ICD-10 Finland
+∞
22.1
21
*
4AA12, ,
NOMESCO Finland
85.0
21.9
24
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.2
20.8
61
164
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
23.9
20.7
29
13
D05AX02
ATC
calcipotriol; topical
7.3
19.8
30
44
D07AC01
ATC
betamethasone; topical
2.6
19.6
187
1004
A06AC01
ATC
ispaghula (psylla seeds); oral
2.8
19.5
138
638
J01MA12
ATC
levofloxacin; systemic
3.1
19.0
99
387
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
20.0
18.9
28
15
5551A
ICD-9 Finland
Regional enteritis, Large intestine
+∞
18.9
18
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
18.7
227
1358
L04AB06
ATC
golimumab; parenteral
26.5
18.4
25
10
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
14.6
18.1
30
22
56300
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Regional enteritis
+∞
17.8
17
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.4
17.7
48
121
JFB20
NOMESCO Finland
Ileocaecal resection
30.4
17.6
23
8
L04AG05
ATC
vedolizumab; parenteral
44.1
17.4
21
5
JFB00
NOMESCO Finland
Partial resection of small intestine
16.9
17.3
27
17
A02BC03
ATC
lansoprazole; oral
2.6
17.2
142
702
L04AA33
ATC
[U] vedolizumab
66.3
16.9
19
*
P01BA02
ATC
hydroxychloroquine; oral
3.7
16.7
58
175
WZC00
NOMESCO Finland
Treatment plan or consultation
2.4
16.7
183
1028
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.4
16.7
68
228
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
29.0
16.7
22
8
5552A
ICD-9 Finland
Regional enteritis, Small intestine with large intestine
177.1
16.6
17
*
R50.9
ICD-10 Finland
Fever, unspecified
2.9
16.5
90
359
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
16.4
118
543
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.3
16.4
70
242
A07DA03
ATC
loperamide; oral
6.5
16.1
27
44
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
16.1
80
302
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.4
15.6
64
215
M25.5
ICD-10 Finland
Pain in joint
2.4
15.6
184
1060
A02BC01
ATC
omeprazole; systemic
2.5
15.5
135
680
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.9
15.4
84
334
D07XC01
ATC
betamethasone; topical
3.2
15.2
68
241
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
46.9
15.2
18
*
JHA00
NOMESCO Finland
Anal or perianal incision
13.2
15.1
26
21
A02BC05
ATC
esomeprazole; systemic
2.3
15.1
193
1148
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.5
14.7
38
92
JHD33
NOMESCO Finland
Completing incision of fistula-in-ano
83.2
14.7
16
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.4
14.5
58
192
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
17.8
14.5
22
13
E0000UV, ,
ATC
2.3
14.3
204
1261
K56.7
ICD-10 Finland
Ileus, unspecified
12.6
14.3
25
21
ZY010
NOMESCO Finland
Hospital outpatient
3.9
14.1
44
123
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.7
13.8
33
75
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.1
13.8
65
237
NH3EA
NOMESCO Finland
Feet X-ray examination with load
12.7
13.8
24
20
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.7
13.5
46
137
D05AX52
ATC
calcipotriol, combinations; topical
4.7
13.3
32
73
WX402
NOMESCO Finland
General anaesthesia
2.4
13.2
119
602
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.2
13.0
208
1330
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
12.1
13.0
23
20
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.4
12.8
116
587
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.6
12.7
44
132
L04AF03
ATC
upadacitinib; oral
72.2
12.7
14
*
JF1AD
NOMESCO Finland
Small bowel CT
20.9
12.6
18
9
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
12.6
12
*
ZXE00
NOMESCO Finland
One hour or less
2.2
12.5
175
1057
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
6.1
12.4
22
38
JX1LA
NOMESCO Finland
Kinetic X-ray of alimentary tract with pictures
38.9
12.3
15
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.3
12.2
21
35
L04AA01
ATC
[U] ciclosporin
18.8
12.2
18
10
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.9
12.2
63
242
M05BA04
ATC
alendronic acid; oral
3.9
12.1
37
102
A02BA02
ATC
ranitidine; systemic
2.6
12.0
82
363
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
48.2
11.9
14
*
A07AA09
ATC
vancomycin; oral
17.1
11.8
18
11
N02BE01
ATC
paracetamol; systemic, rectal
4.2
11.7
377
3184
E000001, ,
ATC
2.4
11.7
101
498
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
67.0
11.7
13
*
UJF02
NOMESCO Finland
Peroral enteroscopy
23.7
11.7
16
7
WW200
NOMESCO Finland
Immunization
5.9
11.6
21
37
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
11.5
105
531
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.2
11.3
48
164
H04.10
ICD-10 Finland
Dry eye syndrome
2.6
11.0
69
292
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.1
11.0
153
912
298, ,
Kela drug reimbursment
44.6
11.0
13
*
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
11.0
107
555
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
10.0
10.9
21
22
B81
ICPC
Anaemia vit B12/folate deficiency
5.1
10.9
23
47
R03AC02
ATC
salbutamol; inhalant
2.1
10.9
253
1817
JHD30
NOMESCO Finland
Incomplete incision of fistula-in-ano
28.9
10.8
14
5
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
22.2
10.8
15
7
A02BX02
ATC
sucralfate; oral
5.5
10.7
21
40
JAH00
NOMESCO Finland
Laparotomy
5.6
10.5
20
37
JFA58
NOMESCO Finland
Endoscopic dilatation of colon
112.9
10.5
11
*
5550A
ICD-9 Finland
Regional enteritis, Small intestine
112.9
10.5
11
*
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
+∞
10.5
10
*
J01FF01
ATC
clindamycin; systemic
2.1
10.4
125
702
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
5.4
10.4
21
41
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
9.2
10.4
21
24
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
9.2
10.4
21
24
3029
Kela drug reimbursment
Upadacitinib
33.5
10.4
13
*
K61.0
ICD-10 Finland
Anal abscess
8.2
10.2
22
28
L04AD01
ATC
ciclosporin; systemic
9.5
10.1
20
22
WZC30
NOMESCO Finland
Teaching
2.4
10.0
81
387
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.8
10.0
52
200
TQW80
NOMESCO Finland
Local dermatologic skincare
5.3
9.9
20
39
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
9.9
115
636
Z3231
NOMESCO Finland
Registered nurse
2.1
9.9
122
691
M01AH05
ATC
etoricoxib; oral
2.1
9.9
282
2144
J01DB01
ATC
cefalexin; oral
2.7
9.8
353
2941
L20
ICPC
Joint symptom/complaint NOS
3.7
9.8
32
92
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.4
9.8
73
335
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
13.8
9.7
16
12
J02AC01
ATC
fluconazole; systemic
2.0
9.7
184
1212
M54.5
ICD-10 Finland
Low back pain
2.0
9.6
169
1085
D07AC13
ATC
mometasone; topical
2.1
9.6
128
745
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
15.5
9.6
15
10
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.8
9.5
49
187
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
102.4
9.5
10
*
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
102.4
9.5
10
*
JFA38
NOMESCO Finland
Endoscopic dilatation of small intestine
102.4
9.5
10
*
L04AC18
ATC
risankizumab; parenteral
30.8
9.5
12
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
9.4
151
938
M075, K509,
ICD-10 Finland
+∞
9.4
9
*
JFB21
NOMESCO Finland
Laparoscopic ileocaecal resection
+∞
9.4
9
*
M074, K508,
ICD-10 Finland
+∞
9.4
9
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.6
9.4
57
237
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.7
9.3
52
207
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
3.5
9.3
33
101
H02AB04
ATC
methylprednisolone; systemic
2.5
9.1
65
292
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
9.1
153
964
D07AD01
ATC
clobetasol; topical
2.3
9.0
80
396
1370
FHL
Colonoscopy, whole colon
24.7
9.0
12
5
L04AB05
ATC
certolizumab pegol; parenteral
24.7
9.0
12
5
A07EA01
ATC
prednisolone; oral, rectal
24.7
9.0
12
5
B01AB05
ATC
enoxaparin; parenteral
2.0
8.9
125
738
NF1AA
NOMESCO Finland
Hip X-ray examination
3.1
8.8
38
131
M01AH03
ATC
valdecoxib; oral
3.6
8.8
30
89
SPAT1263
SPAT
Sampling
1.9
8.7
174
1157
WZA10
NOMESCO Finland
Extensive medical or dental certificate
8.5
8.7
18
22
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
8.6
186
1266
ZX140
NOMESCO Finland
Intra articular
20.6
8.5
12
6
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
4.6
8.5
20
45
JFH10
NOMESCO Finland
Total colectomy and ileostomy
91.9
8.4
9
*
M01AH02
ATC
rofecoxib; oral
2.5
8.4
55
237
5559X
ICD-9 Finland
Regional enteritis, Unspecified site
+∞
8.4
8
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.8
8.3
43
164
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.1
8.3
23
59
J01AA02
ATC
doxycycline; systemic
2.1
8.2
316
2575
M01AX01
ATC
nabumetone; oral
3.9
8.2
24
64
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.9
8.2
24
64
N03AX12
ATC
[U] gabapentin; oral
2.2
8.1
77
392
J01FA06
ATC
roxithromycin; oral
1.8
8.0
166
1110
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.4
8.0
29
90
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.3
7.9
66
318
D07AB08
ATC
desonide; topical
2.4
7.8
57
258
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
7.8
35
124
A03FA02
ATC
cisapride; oral, rectal
3.1
7.7
32
108
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
12.2
7.6
13
11
Z93.2
ICD-10 Finland
Ileostomy status
25.6
7.6
10
*
N06AX11
ATC
mirtazapine; oral
1.8
7.6
150
984
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
7.6
163
1097
N03AX16
ATC
[U] pregabalin
2.0
7.5
97
552
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.2
7.5
30
99
M03BX02
ATC
tizanidine; oral
1.8
7.5
270
2118
A07EC03
ATC
olsalazine; oral
81.5
7.4
8
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
7.4
86
471
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.4
7.4
27
84
M13.8
ICD-10 Finland
Other specified arthritis
9.6
7.3
14
15
4AA33, ,
NOMESCO Finland
+∞
7.3
7
*
M07.0*L40.5
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
+∞
7.3
7
*
6403
FHL
Ileocal resection
+∞
7.3
7
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
7.3
89
497
S18
ICPC
Laceration/cut
1.8
7.3
186
1314
UJD02
NOMESCO Finland
Gastroscopy
3.4
7.2
26
80
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.8
7.2
156
1049
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
30.6
7.2
9
*
J01CA04
ATC
amoxicillin; systemic
2.2
7.2
344
2943
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
4.3
7.1
18
43
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
10.3
7.1
13
13
S01BA01
ATC
dexamethasone; ophthalmic
4.0
7.1
20
52
R01AD12
ATC
fluticasone furoate; nasal
1.8
7.0
153
1029
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
7.0
90
511
SAA01
NOMESCO Finland
Simple examination of mouth
1.9
6.9
314
2611
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
6.8
248
1924
K91.2
ICD-10 Finland
Postsurgical malabsorption, not elsewhere classified
40.8
6.8
8
*
L88
ICD-10 Finland
Pyoderma gangrenosum
40.8
6.8
8
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
6.8
50
228
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.2
6.7
26
84
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
23.0
6.7
9
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.3
6.7
25
79
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.7
6.7
21
59
J01MA14
ATC
moxifloxacin; systemic
2.5
6.6
42
178
SPAT1310
SPAT
Counselling related to known health issue
1.8
6.6
130
844
JHD20
NOMESCO Finland
Incision of fistula-in-ano
8.9
6.6
13
15
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.9
6.5
31
113
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
3.3
6.5
24
75
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
5.9
6.5
17
30
A03CA02
ATC
clidinium and psycholeptics; oral
3.5
6.5
22
65
N05CF02
ATC
zolpidem; oral
2.0
6.5
79
439
Z2446
NOMESCO Finland
Social worker
2.7
6.5
36
143
K83.0
ICD-10 Finland
Cholangitis
7.6
6.5
14
19
L01BB01, ,
ATC
70.9
6.4
7
*
R11
ICD-10 Finland
Nausea and vomiting
2.4
6.4
47
213
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.2
6.4
25
81
D02AE01
ATC
carbamide; topical
2.8
6.4
32
120
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.7
6.4
35
138
C05AA08
ATC
fluocortolone; rectal, topical
2.3
6.4
53
254
D01
ICPC
Abdominal pain/cramps general
2.1
6.4
64
331
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
6.4
120
769
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
11.3
6.3
11
10
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
3.2
6.3
25
82
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
6.3
118
754
J05AB11
ATC
valaciclovir; oral
2.0
6.3
72
391
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
18.4
6.3
9
5
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
7.2
6.3
14
20
107
Kela drug reimbursment
Pernicious anaemia
7.2
6.3
14
20
JH1CM
NOMESCO Finland
Perianal extensive MRI with 3 Tesla magnet
+∞
6.3
6
*
JFA96
NOMESCO Finland
Other local operation on intestine
+∞
6.3
6
*
B04AD01, ,
ATC
27.1
6.2
8
*
NA6CG
NOMESCO Finland
Sacro-iliac joint extensive MRI examination with high intensity magnet
27.1
6.2
8
*
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.5
6.2
21
62
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
6.2
109
683
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
6.2
126
826
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
12.8
6.1
10
8
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
12.8
6.1
10
8
M01CB01
ATC
sodium aurothiomalate; parenteral
12.8
6.1
10
8
K92.1
ICD-10 Finland
Melaena
3.4
6.1
22
68
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
5.3
6.1
17
33
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.8
6.1
30
112
L52
ICD-10 Finland
Erythema nodosum
10.2
6.1
11
11
UJG02
NOMESCO Finland
Proctoscopy
6.2
6.1
15
25
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
6.0
78
442
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
2.9
6.0
28
101
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
6.0
63
331

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
323
568
25.35
217.25
10.5
2.3
184.08
90.10
ug/g
5.75
308
457
239
416
12.79
152.45
2.5
1.3
—
—
—
0
0
69
10
83.18
128.82
2.2
1.9
96.25
—
au/ml
—
9
0
151
295
7.62
80.64
8.9
4.7
0.44
0.65
%
0.71
54
81
298
1124
7.48
78.64
18.4
5.6
—
—
—
0
0
148
292
7.46
78.05
10.0
4.8
0.10
0.18
%
0.52
51
74
152
311
7.27
77.29
9.8
4.7
0.70
0.94
%
0.54
56
93
372
1789
16.42
74.58
25.1
6.0
0.59
0.55
e9/l
3.19
363
1562
372
1795
16.32
74.11
25.2
6.0
0.04
0.04
e9/l
1.17
363
1564
76
8
116.93
71.80
3.9
4.8
8.09
6.51
mg/l
—
59
8
373
1841
16.20
71.39
25.3
6.1
1.93
1.97
e9/l
0.19
366
1648
375
1865
17.17
71.11
25.2
6.4
0.17
0.18
e9/l
1.25
365
1655
142
301
6.76
68.93
10.8
5.2
0.00
0.22
%
0.98
44
69
62
53
13.66
62.45
5.5
3.1
3.95
4.56
e9/l
0.82
62
53
168
457
5.61
61.35
4.4
3.1
4.19
6.48
e9/l
1.03
159
418
374
1999
14.40
61.15
26.0
9.6
4.06
4.00
e9/l
0.23
363
1755
233
844
5.22
59.83
5.4
2.1
2.69
2.73
mg/l
0.08
228
735
177
563
4.85
52.21
1.6
1.4
645.08
471.36
titre
0.79
63
125
229
891
4.67
51.79
16.8
4.9
—
—
—
0
0
63
78
9.40
48.79
5.4
2.8
57.98
58.74
%
0.17
63
78
296
1583
4.35
39.16
28.6
10.4
0.00
0.00
e9/l
0.43
283
1292
385
2580
14.13
37.12
27.7
7.7
74.77
77.44
u/l
1.04
380
2465
146
515
3.89
35.32
1.6
1.6
—
—
—
0
0
174
747
3.35
30.24
1.7
1.7
—
—
—
0
0
306
1868
3.72
28.95
6.1
3.6
0.00
4.15
estimate
0.50
108
391
304
1849
3.68
28.91
6.0
3.5
0.00
0.00
estimate
0.50
109
392
306
1881
3.67
28.34
6.1
3.6
0.00
0.02
estimate
0.80
108
368
250
1408
3.07
25.94
2.6
1.9
95.00
97.83
pmol/l
0.45
183
719
288
1787
3.18
24.54
8.1
6.4
9.72
10.88
umol/l
1.91
279
1710
195
987
2.90
24.14
6.5
3.6
0.00
0.01
estimate
0.80
106
375
155
697
3.00
23.81
1.5
1.3
9.66
9.14
u/ml
0.03
64
278
291
1833
3.16
23.80
6.0
3.1
89.29
102.74
ug/l
0.96
285
1732
169
816
2.85
22.52
5.4
4.2
—
—
—
0
0
89
296
3.58
22.51
2.1
2.5
11.54
10.55
g/l
1.39
80
273
244
1429
2.81
22.27
6.1
3.3
0.04
0.02
estimate
0.32
91
338
141
621
2.96
22.25
2.9
1.7
375.99
21273163.92
pmol/l
0.50
130
550
252
1503
2.83
22.15
4.9
3.3
6.23
6.21
ph
0.13
170
869
88
297
3.52
21.71
3.6
2.6
0.24
0.23
g/l
1.09
81
277
238
1394
2.75
21.42
13.0
9.2
1.13
1.14
inr
0.14
209
1145
200
1075
2.72
21.36
5.4
2.7
57.77
63.70
u/l
0.48
190
1015
72
216
3.85
21.13
1.6
1.2
—
—
—
0
0
31
44
7.55
21.07
1.5
1.3
—
—
—
0
0
75
234
3.71
20.78
1.7
1.5
1.42
1.29
g/l
0.33
68
216
68
199
3.91
20.66
1.1
1.1
—
—
—
0
0
156
773
2.67
19.16
1.5
1.4
19.18
27.07
iu/ml
0.85
50
239
180
957
2.60
19.13
4.3
4.1
7.39
7.40
ph
0.55
140
658
217
1261
2.58
19.12
5.4
3.3
28.81
29.90
u/l
0.44
202
1197
148
715
2.70
19.12
3.9
2.6
5.02
6.74
e6/l
0.64
140
645
60
170
3.98
19.01
1.9
1.9
3.33
4.34
iu/ml
0.30
21
37
171
912
2.53
17.75
2.2
2.1
—
—
—
0
0
247
1562
2.52
17.65
7.5
7.2
1.21
1.21
mmol/l
0.02
217
1370
76
283
3.08
15.66
5.2
3.5
7.38
7.39
ph
0.12
58
163
79
302
3.01
15.54
2.2
2.1
0.00
0.07
estimate
0.78
26
76
73
270
3.08
15.20
5.1
3.4
1.35
1.68
mmol/l
0.25
64
230
222
1401
2.31
15.04
6.8
6.4
1.21
1.21
mmol/l
0.08
206
1308
103
462
2.66
14.96
2.8
2.1
—
—
—
0
0
164
915
2.34
14.81
4.0
2.9
0.22
0.39
e6/l
1.07
138
643
30
60
5.32
14.55
1.9
1.3
9492.96
16218.51
e6/l
0.32
24
43
179
1043
2.30
14.53
14.7
5.9
—
—
—
0
0
184
1086
2.29
14.47
5.4
2.9
0.04
0.01
estimate
0.69
89
328
74
285
2.96
14.31
5.9
3.5
—
—
—
0
0
50
152
3.62
14.21
1.8
1.5
10.82
13.67
iu/ml
—
5
7
69
257
3.04
14.14
2.8
2.6
0.29
0.15
e6/l
0.61
69
244
155
860
2.31
14.02
2.3
2.5
324.20
333.37
umol/l
0.56
144
775
180
1067
2.25
13.85
4.5
3.0
13.94
112.54
e6/l
0.92
155
787
45
130
3.77
13.77
1.6
1.3
—
—
—
0
0
392
3478
7.35
13.54
44.0
13.3
13.02
21.29
mg/l
14.65
374
2796
201
1259
2.20
13.35
5.1
3.7
31.55
50.15
e6/l
0.57
164
839
99
465
2.50
12.89
1.3
1.2
—
—
—
0
0
88
392
2.60
12.80
2.5
1.6
—
—
—
0
0
95
458
2.41
11.58
2.0
1.6
1225.84
1217.06
nmol/l
0.03
72
347
86
410
2.40
10.68
7.0
6.7
104.49
104.48
mmol/l
0.01
86
410
114
613
2.20
10.66
3.8
2.7
507.34
533.22
mosm/kgh2o
0.54
107
536
73
323
2.54
10.65
1.4
1.5
—
—
—
0
0
73
325
2.52
10.50
3.0
2.6
32.64
30.18
u/l
0.37
61
262
24
53
4.75
10.38
1.0
1.2
—
—
—
0
0
30
81
3.92
10.07
1.5
1.2
342.50
243.30
u/ml
0.79
20
44
57
229
2.74
10.06
2.1
3.2
75.39
74.65
e9/l
0.04
41
162
262
1936
2.02
10.01
5.3
4.9
6.50
6.52
mmol/l
0.04
256
1808
148
902
2.02
9.82
2.1
1.5
17.94
20.87
nmol/l
2.06
136
778
184
1212
1.96
9.74
3.6
3.2
18.72
37.11
ng/l
2.29
111
734
138
829
2.01
9.47
6.1
3.5
1.02
1.02
kg/l
0.16
105
536
32
101
3.36
8.56
1.9
2.0
2.66
1.44
ug/l
0.22
32
94
37
130
3.03
8.31
1.4
1.2
—
—
—
0
0
39
145
2.87
7.93
1.5
1.3
—
—
—
0
0
132
829
1.88
7.67
1.8
1.7
0.94
1.04
mg/l
0.20
105
638
41
160
2.74
7.63
3.4
3.1
23.67
24.21
mmol/l
0.44
41
160
195
1389
1.79
7.46
3.0
2.0
—
—
—
0
0
128
804
1.87
7.39
5.7
3.5
—
0.00
—
0
5
163
1109
1.79
7.23
3.2
3.1
2.34
2.35
mmol/l
0.41
155
1017
30
102
3.10
7.13
1.6
1.3
310.00
309.11
ug/g
0.01
16
55
51
232
2.37
6.93
7.7
8.4
8.36
8.78
mmol/l
0.18
51
225
29
104
2.93
6.30
1.3
1.2
—
—
—
0
0
13
17
7.86
6.17
1.2
1.2
3435.38
30878.09
e6/l
—
8
11
27
95
2.98
6.07
1.1
1.2
—
—
—
0
0
42
186
2.41
6.05
1.3
2.5
—
—
—
0
0
48
226
2.28
6.02
3.2
3.7
1.24
1.23
mmol/l
0.80
39
196
17
45
3.90
5.87
1.6
1.2
—
—
—
0
0
38
163
2.47
5.86
1.7
2.3
0.00
0.02
estimate
0.49
19
63
90
540
1.86
5.85
3.8
3.4
0.78
0.82
mmol/l
3.22
85
517
323
2764
1.88
5.80
4.7
4.5
14.82
14.53
pmol/l
1.32
299
2573
135
916
1.72
5.78
4.2
2.7
—
—
—
0
0
32
127
2.65
5.78
1.2
2.4
1.45
1.39
g/l
0.13
27
114
17
36
4.88
5.67
1.1
1.4
22.88
20.40
ng/l
0.21
17
36
78
453
1.90
5.60
1.6
1.5
—
—
—
0
0
378
3447
2.76
5.44
26.9
14.9
139.23
139.73
mmol/l
4.19
372
3380
72
412
1.91
5.39
4.3
2.9
5.26
6.98
umol/l
1.19
64
363
378
3453
2.72
5.31
27.0
15.0
3.91
3.95
mmol/l
2.75
372
3375
24
88
2.84
5.03
3.1
2.5
0.58
2.33
index
1.27
12
48
83
513
1.78
4.85
3.1
2.7
2.30
2.54
e6/l
0.12
49
228
49
257
2.03
4.70
4.9
8.4
—
—
—
0
0
358
3238
2.01
4.48
5.6
5.4
1.80
1.84
mu/l
0.29
340
3054
72
437
1.79
4.45
1.6
1.2
—
—
—
0
0
280
2372
1.60
4.41
4.0
3.6
—
0.20
—
0
5
35
165
2.23
4.40
5.5
7.5
—
—
—
0
0
49
267
1.95
4.23
3.2
1.9
6.12
6.14
ph
0.04
34
166
123
873
1.59
4.21
1.7
1.4
2.98
2.32
g/l
2.15
89
572
149
1106
1.55
4.19
2.9
2.2
—
—
—
0
0
206
1645
1.52
4.12
3.4
2.7
—
—
estimate
—
0
0
22
486
0.42
3.99
1.1
1.3
—
—
—
0
0
12
28
4.38
3.85
2.1
2.5
—
—
—
0
0
7
8
8.88
3.78
1.7
2.0
21.57
27.88
%
—
7
8
7
8
8.88
3.78
1.9
2.3
52.14
58.06
%
—
7
8
12
31
3.96
3.52
1.1
1.3
—
—
nmol/l
—
0
0
55
342
1.71
3.12
6.0
9.3
7.41
7.42
ph
0.20
33
199
54
335
1.71
3.09
6.1
9.4
0.36
0.72
mmol/l
0.27
46
282
17
68
2.57
3.08
5.2
4.2
—
—
—
0
0
20
88
2.34
2.99
1.8
2.9
7.41
7.41
ph
0.07
20
88
69
465
1.58
2.87
1.8
1.9
29.37
29.16
s
0.14
69
455
18
77
2.40
2.86
1.2
3.6
1.41
2.36
ratio
—
9
45
11
33
3.40
2.83
1.4
2.4
0.80
1.19
%
—
6
19
10
28
3.64
2.80
2.1
2.0
43.74
39.47
%
—
10
28
12
39
3.14
2.79
1.1
1.4
—
—
—
0
0
36
207
1.81
2.68
2.4
2.2
4206.32
5410.64
u/l
0.14
13
86
382
3632
2.15
2.68
26.9
12.0
—
—
—
0
0
35
204
1.78
2.51
2.3
1.5
0.24
0.28
mg/l
0.22
19
95
9
26
3.52
2.49
2.1
1.3
—
—
—
0
0
10
32
3.18
2.45
1.0
1.1
—
—
—
0
0
31
176
1.83
2.42
3.0
3.7
92.90
100.90
ng/l
0.11
25
162
33
193
1.77
2.35
2.5
2.8
4.85
5.10
kpa
1.40
33
187
26
141
1.90
2.33
2.3
1.7
—
—
—
0
0
6
13
4.67
2.28
1.0
1.2
—
—
—
0
0
25
135
1.91
2.28
6.7
4.0
36.95
36.95
°c
0.00
25
135
10
35
2.90
2.22
2.6
3.0
—
—
—
0
0
10
35
2.90
2.22
1.4
2.3
32.80
32.86
pg
—
10
35
394
3835
2.82
2.20
57.1
20.5
4.45
4.55
e12/l
4.91
389
3772
394
3836
2.81
2.20
57.2
20.6
7.06
6.64
e9/l
4.23
389
3769
8
24
3.38
2.19
1.1
2.9
—
—
—
0
0
6
14
4.33
2.16
2.2
1.6
—
—
—
0
0
14
62
2.30
2.10
2.9
2.5
—
—
—
0
0
21
110
1.96
2.10
1.2
1.3
—
—
—
0
0
6
16
3.79
1.94
1.5
1.3
0.00
0.00
estimate
—
6
16
121
980
1.34
1.87
1.4
1.3
0.92
1.32
u/ml
0.64
30
283
31
193
1.66
1.81
4.4
7.4
25.79
24.49
mmol/l
0.95
31
193
42
283
1.54
1.78
1.4
1.3
73.78
305.12
u/ml
1.49
37
262
6
18
3.37
1.75
1.8
5.2
16.37
17.51
%
—
6
18
10
41
2.48
1.65
1.3
3.2
—
—
—
0
0
20
113
1.81
1.63
3.4
3.2
1.32
1.39
mg/l
0.19
20
102
5
14
3.60
1.62
4.4
3.2
0.53
0.62
mmol/l
—
5
14
5
14
3.60
1.62
1.2
1.6
89.60
63.50
nmol/24h
—
5
14
8
32
2.53
1.60
1.5
1.5
92.16
91.82
%
—
8
32
6
20
3.03
1.58
2.8
3.7
840.00
949.60
mg
—
6
20
25
392
0.61
1.58
1.6
1.8
3.35
3.50
mmol/l
0.35
16
289
6
21
2.88
1.51
1.5
1.4
132.00
159.74
nmol/l
—
6
21
77
605
1.34
1.45
2.0
2.6
2.44
2.43
mmol/l
0.14
70
534
43
307
1.45
1.42
3.9
4.7
3.60
23.17
ug/l
0.76
30
244
6
23
2.63
1.37
1.3
1.1
—
—
—
0
0
0
37
0.00
1.35
0.0
11.7
—
0.58
—
0
37
0
40
0.00
1.33
0.0
16.1
—
839.60
—
0
40
5
18
2.80
1.29
1.0
1.1
73.78
166.53
iu/ml
—
5
18
6
25
2.42
1.25
1.0
1.1
—
—
—
0
0
34
241
1.45
1.18
2.7
3.6
86.47
83.42
ng/l
0.06
29
218
12
65
1.87
1.14
1.1
1.1
—
—
—
0
0
7
30
2.36
1.13
1.1
1.2
—
—
—
0
0
344
3294
1.32
1.12
4.5
4.6
5.83
5.81
mmol/l
0.14
322
3097
14
81
1.75
1.10
1.6
2.4
1.38
0.91
nmol/l
0.89
14
72
5
21
2.40
1.09
1.2
1.0
1557.00
1565.38
miu/ml
—
5
21
38
500
0.73
1.02
2.5
2.7
0.70
0.73
ug/l
0.09
19
271
6
27
2.24
0.94
2.8
2.1
25.83
42.85
mg/l
—
6
20
17
110
1.57
0.92
1.8
2.1
1.80
4.87
iu/l
—
9
49
5
105
0.47
0.90
1.2
1.3
—
—
—
0
0
8
43
1.88
0.88
2.1
1.8
11.88
10.44
mmol/l
—
8
43
276
2605
1.19
0.87
4.8
3.4
54.13
44.05
u/l
1.08
266
2502
112
979
1.20
0.87
3.1
3.5
90.98
57.39
mg/l
0.37
76
629
6
30
2.01
0.87
3.0
3.2
2.27
3.46
nmol/l
—
6
30
127
1126
1.19
0.84
3.3
3.4
7.67
8.13
mmol/l
0.57
115
977
10
57
1.77
0.84
2.3
2.6
5.00
4.97
kpa
—
10
57
10
57
1.77
0.84
2.3
2.6
9.35
9.07
kpa
—
10
57
18
260
0.68
0.84
1.6
1.7
—
—
—
0
0
67
560
1.24
0.81
1.9
1.5
—
—
—
0
0
11
66
1.69
0.79
3.1
3.5
41.91
34.82
umol/l
0.55
11
60
8
48
1.68
0.79
1.9
2.5
—
33.25
—
0
6
8
48
1.68
0.79
1.6
1.5
—
—
—
0
0
8
48
1.68
0.79
1.6
1.5
—
—
—
0
0
8
48
1.68
0.79
1.6
1.5
—
—
—
0
0
8
48
1.68
0.79
1.6
1.5
—
—
—
0
0
21
149
1.43
0.77
2.0
1.7
—
—
—
0
0
6
34
1.78
0.76
13.7
9.9
6.30
7.04
mmol/l
—
6
27
5
24
2.10
0.74
1.2
1.1
—
—
—
0
0
113
1003
1.18
0.74
4.0
4.2
17.90
8.94
mg/mmol
0.47
75
624
5
25
2.01
0.73
1.2
1.0
—
—
—
0
0
12
76
1.60
0.72
1.3
1.4
—
—
—
0
0
12
181
0.65
0.71
1.0
1.1
1.73
1.55
g/l
0.93
12
181
66
560
1.21
0.71
2.4
1.8
—
—
—
0
0
11
71
1.56
0.62
1.1
1.1
—
—
—
0
0
140
1522
0.88
0.60
2.2
1.9
1.70
1.40
mmol/l
1.57
123
1312
0
22
0.00
0.59
0.0
1.4
—
—
—
0
0
0
22
0.00
0.59
0.0
2.0
—
—
—
0
0
11
161
0.67
0.58
1.1
1.6
75.50
60.88
ug/l
0.58
11
138
8
123
0.64
0.55
1.1
1.5
—
—
—
0
0
8
125
0.63
0.55
1.3
1.6
—
—
—
0
0
9
61
1.49
0.54
1.8
1.8
—
—
—
0
0
6
39
1.55
0.53
1.2
1.2
—
—
—
0
0
38
452
0.82
0.50
1.3
1.8
—
—
—
0
0
7
45
1.57
0.49
1.0
1.3
—
—
—
0
0
19
242
0.77
0.46
1.2
1.1
—
—
—
0
0
8
121
0.65
0.46
1.0
1.5
1.30
1.29
mm
—
8
87
22
175
1.27
0.44
3.5
3.1
—
—
—
0
0
5
32
1.57
0.42
1.2
1.2
116.10
176.78
pmol/l
—
5
32
31
259
1.21
0.42
2.8
4.0
7.34
7.33
ph
0.07
25
190
10
70
1.44
0.42
1.1
1.2
—
—
—
0
0
5
33
1.52
0.41
1.0
1.0
—
0.18
—
0
15
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
72.20
—
0
10
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
339
3457
0.87
0.40
4.7
4.7
1.43
1.47
mmol/l
1.36
319
3269
329
3214
1.13
0.40
6.2
5.7
37.64
38.44
mmol/mol
1.02
317
3069
8
60
1.34
0.40
2.3
3.7
6.09
9.54
pmol/l
—
8
60
0
19
0.00
0.39
0.0
1.5
—
49528.38
—
0
8
18
143
1.27
0.37
1.8
2.1
—
—
—
0
0
21
171
1.24
0.36
1.6
1.3
237.24
266.53
miu/ml
0.16
13
84
5
78
0.64
0.36
1.8
2.9
53.80
62.88
%
—
5
78
16
126
1.28
0.35
2.5
3.1
—
—
—
0
0
6
42
1.43
0.35
3.7
2.3
—
—
—
0
0
6
44
1.37
0.34
1.2
1.0
—
—
titre
—
0
0
345
3505
0.89
0.32
5.2
5.3
2.65
2.81
mmol/l
3.07
325
3320
15
119
1.27
0.32
1.3
1.2
—
—
—
0
0
7
54
1.30
0.30
2.0
1.2
—
—
—
0
0
11
84
1.32
0.30
1.7
2.0
—
—
—
0
0
12
93
1.30
0.30
2.0
2.4
—
—
—
0
0
7
55
1.28
0.30
1.1
1.2
—
—
—
0
0
7
56
1.25
0.29
1.3
1.9
—
—
—
0
0
15
184
0.81
0.29
1.7
1.1
0.83
0.91
g/l
1.49
15
184
21
248
0.84
0.29
1.3
1.2
—
—
—
0
0
12
151
0.79
0.28
1.8
1.6
18.79
8.31
u/ml
—
7
39
23
197
1.18
0.26
1.9
2.2
—
—
—
0
0
30
340
0.87
0.26
1.2
1.2
—
—
—
0
0
9
73
1.24
0.25
1.1
1.3
—
—
—
0
0
11
87
1.27
0.24
1.0
1.2
3.45
3.80
mmol/l
0.71
11
81
12
97
1.24
0.23
1.3
1.1
—
—
—
0
0
66
615
1.09
0.22
4.5
3.6
14.47
418.59
ng/l
2.39
46
411
0
10
0.00
0.21
0.0
2.1
—
13.87
—
0
10
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
3.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
324
3284
0.93
0.20
4.2
4.0
1.49
1.29
mmol/l
4.06
303
3096
12
100
1.21
0.18
1.2
1.1
0.09
1.06
u/ml
—
5
50
5
68
0.73
0.17
1.0
1.0
—
0.41
—
0
22
7
86
0.81
0.14
1.0
1.0
—
1.13
—
0
42
25
228
1.10
0.13
2.2
2.1
—
—
—
0
0
344
3469
0.94
0.13
4.9
4.8
4.58
4.74
mmol/l
2.33
327
3298
10
87
1.15
0.09
1.1
1.2
1.40
10.94
e6/l
—
10
62
7
68
1.03
0.08
1.1
1.0
—
—
—
0
0
10
89
1.13
0.07
1.2
1.3
3.50
173.72
e6/l
—
10
67
10
111
0.90
0.06
19.6
6.9
—
—
—
0
0
28
269
1.04
0.04
1.6
1.3
—
—
—
0
0
17
180
0.94
0.04
1.2
1.6
203.47
293.02
mu/l
2.61
17
161
158
1596
0.98
0.04
3.4
2.9
—
—
—
0
0
42
411
1.02
0.02
1.8
1.4
—
—
—
0
0
113
1123
1.01
0.01
1.5
1.6
—
—
—
0
0
12
114
1.05
0.00
2.2
2.8
—
—
—
0
0
25
248
1.01
0.00
2.2
2.0
—
—
—
0
0
25
248
1.01
0.00
2.2
2.0
—
—
—
0
0
12
119
1.01
0.00
1.7
1.8
240.58
232.57
pmol/l
0.14
12
113
25
249
1.00
0.00
2.3
2.0
—
—
—
0
0
10
97
1.03
0.00
1.1
1.1
—
—
—
0
0
10
97
1.03
0.00
1.1
1.1
—
—
—
0
0
33
325
1.02
0.00
1.2
1.3
50.76
176.32
u/ml
4.75
12
133
7
75
0.93
0.00
1.0
1.1
—
5.30
—
0
32
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
25
250
1.00
-0.00
2.2
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
0.04
—
0
9
6
69
0.87
-0.00
1.8
1.6
—
—
—
0
0
8
86
0.93
-0.00
1.0
1.0
—
1.00
—
0
36
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
61.71
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
1.84
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
70.32
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
15
150
1.00
-0.00
1.9
1.8
33.40
38.23
nmol/l
0.73
15
145
0
7
0.00
-0.00
0.0
1.0
—
6.21
—
0
7

Mortality – FinRegistry

↥

Association

Association between endpoint CROHN_ARTHR and mortality.

Females

Parameter HR [95% CI] p-value
CROHN_ARTHR 1.408 [1.06, 1.87] 0.018
Birth year 0.991 [0.98, 1.0] 0.035

During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 730 females with CROHN_ARTHR died.

Males

Parameter HR [95% CI] p-value
CROHN_ARTHR 1.394 [1.06, 1.83] 0.018
Birth year 0.985 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 562 males with CROHN_ARTHR died.

Mortality risk

Mortality risk for people of age

years, who have CROHN_ARTHR.

N-year risk Females Males
1 0.125% 0.215%
5 0.773% 1.587%
10 1.813% 3.786%
15 3.506% 7.126%
20 5.89% 11.945%

Relationships between endpoints

↥

Index endpoint: CROHN_ARTHR – Arthropathy in Crohn disease

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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