Carcinoma in situ of uteri, other/unspecified

CD2_INSITU_CERVIX_UTERI_NOS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D06.7&, D06.9&
  • Hospital discharge: ICD-9 2331
  • Cause of death: ICD-10 D06.7&, D06.9&
  • Cause of death: ICD-9 2331

2 out of 7 registries used, show all original rules.

246

4. Check minimum number of events

None

246

5. Include endpoints

None

246

6. Filter based on genotype QC (FinnGen only)

225

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 225 225 -
Unadjusted period prevalence (%) 0.08 0.08 -
Median age at first event (years) 35.70 35.70 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
230
Matched controls
2300
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8070/2-C53.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of cervix uteri
683.6
170.9
149
6
D06.9
ICD-10 Finland
Carcinoma in situ: Cervix, unspecified
+∞
151.3
128
*
2331A
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Cervix uteri
+∞
116.9
102
*
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
16.4
74.2
72
62
8326
FHL
Batch conization
300.0
67.1
65
*
ULA02
NOMESCO Finland
Kolposcopy
9.1
59.4
101
183
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
17.6
53.5
47
33
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
8.1
52.5
98
194
LDA10
NOMESCO Finland
Curettage of cervix uteri
9.7
40.0
53
69
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
116.8
37.0
39
*
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
5.4
32.9
89
239
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
6.0
27.7
58
122
D06.1
ICD-10 Finland
Carcinoma in situ: Exocervix
115.0
19.9
21
*
LDC00
NOMESCO Finland
Conisation of cervix uteri using knife
+∞
15.8
15
*
8140/2-C53.9
ICD-O-3
Adenocarcinoma in situ, NOS, of cervix uteri
171.2
15.7
16
*
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
15.1
13.5
22
16
D06.7
ICD-10 Finland
Carcinoma in situ: Other parts of cervix
+∞
8.4
8
*
8076/3-C53.9
ICD-O-3
Squamous cell carcinoma, microinvasive of cervix uteri
+∞
8.4
8
*
8070/3-C53.9
ICD-O-3
Squamous cell carcinoma, NOS, of cervix uteri
82.6
7.5
8
*
ZXC00
NOMESCO Finland
Use of diathermy
17.3
6.8
10
6
C53.11
ICD-10 Finland
Squamous cell carcinoma and exocervix
71.8
6.5
7
*
8140/2-C53.1
ICD-O-3
Adenocarcinoma in situ, NOS, of exocervix
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
58
2.89
3.50
2.3
1.8
—
—
—
0
0
13
39
3.47
3.28
1.3
1.7
—
—
—
0
0
29
517
0.50
3.15
1.3
1.4
1.80
2.14
g/l
1.26
19
316
15
60
2.60
2.76
10.1
5.9
—
—
—
0
0
38
587
0.58
2.48
1.4
1.3
2.07
1.98
u/ml
0.02
11
170
88
663
1.53
2.44
1.9
2.2
—
—
—
0
0
11
258
0.40
2.44
2.5
1.4
—
—
—
0
0
91
1116
0.69
1.94
3.8
3.1
95.62
84.72
ug/l
0.20
86
1054
70
894
0.69
1.83
2.0
2.0
93.45
99.77
pmol/l
0.66
33
442
68
512
1.47
1.82
3.6
3.8
1.02
1.02
kg/l
0.43
39
337
21
352
0.56
1.81
2.3
1.5
—
—
—
0
0
24
372
0.60
1.54
2.0
1.4
257.78
522.35
titre
—
9
85
189
2010
0.67
1.48
5.0
4.9
5.84
5.77
mmol/l
0.38
178
1892
13
67
2.00
1.41
1.5
1.3
—
—
—
0
0
7
146
0.46
1.37
3.9
2.1
65.91
67.58
g/l
—
7
138
5
17
2.98
1.36
1.0
1.0
—
—
—
0
0
13
68
1.97
1.36
1.5
1.3
—
—
—
0
0
13
68
1.97
1.36
1.5
1.3
—
—
—
0
0
13
68
1.97
1.36
1.5
1.3
—
—
—
0
0
0
39
0.00
1.35
0.0
2.3
—
—
—
0
0
196
2062
0.67
1.30
13.3
13.3
18.16
19.82
mg/l
0.36
158
1637
95
1111
0.75
1.30
7.1
6.2
1.97
1.91
e9/l
0.21
84
977
199
2086
0.66
1.26
15.0
14.9
3.91
3.92
mmol/l
0.13
194
2046
9
168
0.52
1.24
2.4
1.3
—
—
—
0
0
199
2085
0.66
1.24
14.9
14.8
139.99
139.91
mmol/l
0.18
194
2048
6
127
0.46
1.21
1.3
1.1
—
—
—
0
0
8
38
2.14
1.19
5.5
3.7
—
—
—
0
0
0
34
0.00
1.17
0.0
1.6
—
—
—
0
0
10
181
0.53
1.14
2.7
1.8
—
—
—
0
0
107
926
1.29
1.12
4.0
3.4
6.19
6.23
ph
0.15
60
543
86
1005
0.77
1.12
6.3
6.1
3.01
2.81
%
0.34
81
936
95
1096
0.77
1.11
6.5
6.2
0.04
0.04
e9/l
0.01
82
931
95
1091
0.78
1.06
6.4
6.2
0.51
0.53
e9/l
0.52
82
930
100
1141
0.78
1.05
6.3
6.5
0.21
0.18
e9/l
1.12
86
996
87
1009
0.78
1.04
6.1
6.1
7.73
8.57
%
2.78
82
941
87
1006
0.78
1.01
6.0
6.1
0.72
0.75
%
0.21
81
931
12
198
0.58
1.01
1.2
1.1
—
—
—
0
0
7
35
2.03
1.01
3.3
2.4
7.36
7.57
mmol/l
—
7
35
58
704
0.76
0.98
6.2
5.7
—
—
—
0
0
0
31
0.00
0.97
0.0
1.8
—
—
—
0
0
8
145
0.54
0.96
1.0
1.6
1.44
1.39
g/l
—
8
133
9
51
1.80
0.95
1.6
1.3
—
—
—
0
0
29
217
1.38
0.82
2.0
2.1
0.00
0.06
estimate
—
8
49
211
2167
0.68
0.76
11.9
11.8
26.60
24.38
u/l
0.28
206
2121
12
76
1.61
0.73
6.0
4.0
36.65
36.95
°c
0.67
12
76
202
2086
0.74
0.71
4.8
5.1
4.94
4.93
mmol/l
0.02
193
1976
83
729
1.22
0.70
3.8
3.3
168.34
23.43
ng/l
0.75
40
445
29
224
1.34
0.69
1.6
1.5
—
—
—
0
0
7
42
1.69
0.69
3.4
2.3
1.33
1.42
mmol/l
—
7
42
12
178
0.66
0.68
2.6
2.5
—
15.92
—
0
11
50
591
0.80
0.66
1.5
1.6
22.38
21.88
nmol/l
0.08
44
496
12
177
0.66
0.66
1.3
2.5
10.79
10.06
g/l
0.40
12
166
188
1955
0.79
0.65
6.2
5.8
38.87
38.31
mmol/mol
0.50
180
1860
26
332
0.76
0.64
6.1
3.0
0.77
0.81
mmol/l
1.06
26
316
87
969
0.84
0.63
1.8
1.9
1.52
1.37
mmol/l
1.14
78
828
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
112
1217
0.84
0.60
11.4
10.0
3.93
3.86
e9/l
0.11
98
1049
0
21
0.00
0.60
0.0
1.7
—
10.97
—
0
21
17
229
0.72
0.59
4.4
4.4
1.05
1.07
mmol/l
0.14
17
202
23
176
1.34
0.59
3.2
2.9
7.38
7.39
ph
0.06
12
95
84
751
1.19
0.58
3.9
3.7
35.16
58.93
e6/l
0.47
61
488
205
2104
0.76
0.55
5.5
5.7
2.92
2.89
mmol/l
0.12
194
1987
202
2076
0.78
0.54
4.6
5.0
1.56
1.59
mmol/l
0.67
191
1958
9
62
1.47
0.53
1.6
1.3
—
—
—
0
0
57
650
0.84
0.53
2.3
2.0
167.26
138.15
u/l
0.22
57
624
101
927
1.16
0.49
2.1
2.1
—
—
—
0
0
45
520
0.83
0.48
3.4
1.7
1.27
1.06
mg/l
0.20
37
418
8
116
0.68
0.47
1.0
1.1
—
—
—
0
0
13
94
1.41
0.47
2.0
1.7
—
—
—
0
0
57
643
0.85
0.46
5.3
3.1
0.11
0.01
estimate
0.45
18
191
12
163
0.72
0.45
3.1
3.6
—
—
—
0
0
12
162
0.73
0.44
2.2
3.4
62.09
72.31
ng/l
0.51
12
143
74
669
1.16
0.44
3.0
3.0
6.67
6.95
mmol/l
0.17
65
558
21
167
1.28
0.43
1.4
1.3
—
—
—
0
0
26
213
1.25
0.43
1.6
1.8
3.71
3.51
mmol/l
0.40
21
164
124
1164
1.14
0.43
4.9
3.9
0.05
0.04
estimate
0.05
22
231
35
297
1.21
0.42
3.6
2.8
5.58
3.94
e6/l
0.46
19
122
99
917
1.14
0.41
2.9
3.0
—
—
—
0
0
32
376
0.83
0.41
2.3
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
1.13
—
0
6
0
15
0.00
0.41
0.0
1.3
—
46.45
—
0
15
0
15
0.00
0.41
0.0
1.1
—
0.50
—
0
10
0
16
0.00
0.41
0.0
1.6
—
64.00
—
0
16
0
17
0.00
0.41
0.0
1.1
—
33.29
—
0
17
5
34
1.48
0.40
1.2
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.8
—
40.67
—
0
12
5
35
1.44
0.39
1.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
2.1
—
—
—
0
0
21
170
1.26
0.39
5.8
3.5
4.55
4.50
pmol/l
0.11
21
153
172
1780
0.87
0.38
5.1
5.0
14.93
14.58
pmol/l
1.11
164
1667
5
36
1.40
0.38
1.4
1.4
—
—
—
0
0
123
1160
1.13
0.38
3.8
4.2
6.78
6.39
mmol/l
1.02
118
1096
16
201
0.78
0.37
1.2
1.3
132.34
154.47
u/ml
—
9
92
12
157
0.75
0.37
1.2
1.4
—
25.15
—
0
10
71
648
1.14
0.37
5.8
6.9
—
—
—
0
0
30
255
1.20
0.36
1.7
1.7
—
—
—
0
0
14
108
1.32
0.36
5.3
9.1
92.36
94.70
%
0.94
14
108
24
282
0.83
0.32
1.2
1.3
—
—
—
0
0
25
292
0.84
0.31
1.5
1.6
1337.00
1175.59
nmol/l
0.38
20
219
7
99
0.70
0.31
1.1
1.3
—
—
—
0
0
13
102
1.29
0.30
3.5
2.2
0.58
0.57
%
0.05
13
102
33
375
0.86
0.30
3.0
3.5
50.74
299.98
ng/l
0.75
19
251
27
234
1.17
0.28
4.7
6.1
104.33
104.20
mmol/l
0.08
27
234
104
985
1.10
0.28
2.6
2.6
—
—
estimate
—
0
0
120
1147
1.10
0.26
4.9
3.8
0.00
0.00
estimate
-0.00
24
231
30
266
1.15
0.24
1.1
1.4
—
—
—
0
0
14
115
1.23
0.24
1.9
2.1
0.00
0.02
estimate
—
7
45
45
491
0.90
0.23
1.4
1.3
24.39
12.01
u/ml
0.32
15
204
68
637
1.10
0.22
4.4
3.7
4.05
9.06
mg/mmol
0.93
39
350
12
145
0.82
0.21
5.7
8.0
—
—
—
0
0
8
102
0.78
0.21
2.5
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
3.4
—
7.36
—
0
10
0
10
0.00
0.21
0.0
1.2
—
259.40
—
0
10
0
12
0.00
0.21
0.0
1.3
—
92.06
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.17
0.21
1.6
1.7
0.39
0.87
nmol/l
—
5
35
93
886
1.08
0.21
5.0
3.6
0.07
0.02
estimate
0.33
15
190
0
13
0.00
0.21
0.0
1.1
—
679.50
—
0
8
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
156.67
—
0
13
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
3.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
58.85
—
0
13
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
66
620
1.09
0.20
3.5
3.1
13.97
67.02
e6/l
1.35
53
456
120
1156
1.08
0.20
4.9
3.8
0.00
6.79
estimate
0.50
24
239
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
76.04
—
0
9
25
280
0.88
0.20
1.8
1.9
—
—
—
0
0
58
545
1.09
0.18
3.2
3.0
0.17
0.45
e6/l
1.59
42
379
7
61
1.15
0.17
1.4
1.5
—
—
—
0
0
22
244
0.89
0.15
1.1
1.4
—
—
—
0
0
9
82
1.10
0.15
1.1
1.1
—
0.57
—
0
9
7
89
0.78
0.14
1.1
1.3
—
2.54
—
0
11
7
89
0.78
0.14
1.0
1.2
—
—
—
0
0
66
629
1.07
0.14
3.8
3.9
0.00
0.00
estimate
-0.00
23
224
63
661
0.94
0.14
3.4
2.3
49.11
68.60
u/l
1.76
56
615
12
103
1.17
0.14
3.8
2.3
1.31
1.22
%
0.12
12
103
9
109
0.82
0.13
4.9
6.8
24.90
25.27
mmol/l
—
9
109
43
456
0.93
0.13
3.1
3.6
—
—
—
0
0
50
527
0.93
0.13
1.4
1.4
25.73
30.06
iu/ml
0.14
21
171
20
181
1.11
0.12
4.6
4.8
0.57
1.02
%
—
7
44
63
603
1.06
0.12
1.4
1.5
—
—
—
0
0
30
322
0.92
0.12
1.2
1.2
—
—
—
0
0
94
969
0.95
0.12
9.6
10.3
0.00
0.00
e9/l
0.78
83
779
65
627
1.05
0.09
3.0
3.2
18.32
34.76
mg/l
1.05
38
363
17
186
0.91
0.09
6.1
4.9
0.20
1.45
%
—
5
49
18
196
0.91
0.09
2.0
1.4
—
—
—
0
0
6
56
1.07
0.08
4.2
1.6
206.45
207.59
ug/l
—
6
49
5
60
0.83
0.08
2.2
2.2
21.98
25.36
mmol/l
—
5
60
5
60
0.83
0.08
1.8
1.1
—
—
—
0
0
7
67
1.05
0.08
2.4
3.5
—
—
—
0
0
6
73
0.82
0.07
1.8
1.2
—
—
—
0
0
9
86
1.05
0.07
1.1
1.1
1.56
1.67
g/l
—
9
86
18
168
1.08
0.06
2.9
3.3
1.83
1.89
%
0.10
18
154
23
218
1.06
0.05
1.2
1.5
—
—
—
0
0
25
262
0.95
0.05
1.5
1.3
—
—
—
0
0
211
2121
0.94
0.05
12.1
11.9
—
—
—
0
0
14
130
1.08
0.04
1.5
1.2
—
—
—
0
0
51
522
0.97
0.04
5.9
4.9
—
—
—
0
0
19
181
1.05
0.03
5.5
5.6
0.17
0.30
%
—
6
37
10
92
1.09
0.03
4.2
4.4
—
—
—
0
0
64
650
0.98
0.02
2.4
3.8
7.39
7.40
ph
0.33
49
462
28
272
1.03
0.02
2.5
1.8
28.98
29.40
s
0.14
28
260
103
1021
1.02
0.02
5.0
6.4
1.22
1.22
mmol/l
0.01
91
885
200
2007
0.97
0.01
6.2
6.1
1.78
1.82
mu/l
0.23
192
1895
30
307
0.97
0.01
1.3
1.2
—
—
—
0
0
19
192
0.99
0.00
4.4
7.6
7.41
7.42
ph
—
10
118
18
181
0.99
0.00
1.3
2.4
0.24
0.22
g/l
0.35
18
176
196
1961
1.00
0.00
3.9
4.2
1.27
1.25
mmol/l
0.25
182
1839
176
1759
1.00
0.00
19.3
17.8
331.09
330.77
g/l
0.20
176
1753
66
661
1.00
0.00
3.3
2.8
—
—
—
0
0
22
216
1.02
0.00
4.0
4.1
4.50
8.60
ug/l
0.92
16
168
19
194
0.98
0.00
4.4
7.5
5.36
5.23
kpa
0.45
19
188
19
194
0.98
0.00
4.4
7.5
10.88
12.49
kpa
0.87
19
188
85
855
0.99
0.00
14.6
8.6
1.24
1.11
inr
1.08
69
703
19
185
1.03
0.00
1.7
1.7
—
—
—
0
0
5
56
0.89
0.00
5.0
2.1
—
—
—
0
0
5
51
0.98
-0.00
1.6
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
40.3
—
104.83
—
0
6
7
72
0.97
-0.00
1.7
1.7
263.00
276.54
mu/l
—
7
63
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
19.36
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
25.00
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
80.17
—
0
7
5
55
0.91
-0.00
1.2
1.2
3.36
3.84
mmol/l
—
5
49
5
50
1.00
-0.00
2.2
1.6
8478.60
16362.18
e6/l
—
5
38
5
53
0.94
-0.00
1.6
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
2145.43
—
0
7
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
9
89
1.01
-0.00
1.1
1.2
0.91
0.90
g/l
—
9
89
0
8
0.00
-0.00
0.0
3.8
—
0.75
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
0.02
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_CERVIX_UTERI_NOS – Carcinoma in situ of uteri, other/unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).