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This is a non-core endpoint: only basic statistics are computed.

Carcinoma in situ of uteri, other/unspecified

CD2_INSITU_CERVIX_UTERI_NOS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

only females

293218

2. Check conditions

None

293218

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D06.7&, D06.9&
  • Hospital discharge: ICD-9 2331
  • Cause of death: ICD-10 D06.7&, D06.9&
  • Cause of death: ICD-9 2331

2 out of 7 registries used, show all original rules.

228

4. Check minimum number of events

None

228

5. Include endpoints

None

228

6. Filter based on genotype QC (FinnGen only)

225

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 225 225 -
Unadjusted period prevalence (%) 0.08 0.08 -
Median age at first event (years) 35.70 35.70 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
228
Matched controls
2280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8070/2-C53.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of cervix uteri
694.1
171.2
149
6
D06.9
ICD-10 Finland
Carcinoma in situ: Cervix, unspecified
+∞
148.7
126
*
2331A
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Cervix uteri
+∞
117.0
102
*
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
15.8
70.8
70
62
8326
FHL
Batch conization
301.0
67.1
65
*
ULA02
NOMESCO Finland
Kolposcopy
9.0
58.0
98
176
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
8.3
53.1
96
184
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
17.3
49.9
44
31
LDA10
NOMESCO Finland
Curettage of cervix uteri
9.4
37.7
51
68
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
113.4
36.0
38
*
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
5.4
32.2
87
233
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
6.1
27.7
57
118
D06.1
ICD-10 Finland
Carcinoma in situ: Exocervix
115.1
19.9
21
*
LDC00
NOMESCO Finland
Conisation of cervix uteri using knife
+∞
15.8
15
*
8140/2-C53.9
ICD-O-3
Adenocarcinoma in situ, NOS, of cervix uteri
171.3
15.7
16
*
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
16.7
12.9
20
13
8076/3-C53.9
ICD-O-3
Squamous cell carcinoma, microinvasive of cervix uteri
+∞
8.4
8
*
D06.7
ICD-10 Finland
Carcinoma in situ: Other parts of cervix
+∞
8.4
8
*
8070/3-C53.9
ICD-O-3
Squamous cell carcinoma, NOS, of cervix uteri
82.7
7.5
8
*
C53.11
ICD-10 Finland
Squamous cell carcinoma and exocervix
71.8
6.5
7
*
ZXC00
NOMESCO Finland
Use of diathermy
14.9
6.5
10
7
8140/2-C53.1
ICD-O-3
Adenocarcinoma in situ, NOS, of exocervix
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
41
3.85
5.01
2.3
1.9
—
—
—
0
0
12
31
4.03
3.54
1.2
1.7
—
—
—
0
0
15
60
2.61
2.76
9.7
5.7
—
—
—
0
0
79
572
1.58
2.66
1.8
2.1
—
—
—
0
0
0
57
0.00
2.08
0.0
1.1
—
—
—
0
0
13
57
2.36
2.01
1.3
1.4
—
—
—
0
0
13
57
2.36
2.01
1.3
1.4
—
—
—
0
0
13
57
2.36
2.01
1.3
1.4
—
—
—
0
0
13
57
2.36
2.01
1.3
1.4
—
—
—
0
0
17
84
2.11
2.01
8.2
2.9
—
—
—
0
0
27
431
0.58
1.96
1.2
1.3
1.85
2.12
g/l
0.91
18
263
5
11
4.62
1.95
5.8
6.3
—
—
—
0
0
10
215
0.44
1.81
2.5
1.4
—
—
—
0
0
60
442
1.49
1.79
3.2
3.5
—
—
—
0
0
5
15
3.38
1.53
1.0
1.0
—
—
—
0
0
25
157
1.67
1.48
3.1
3.4
—
—
—
0
0
8
165
0.47
1.42
3.9
3.9
—
—
—
0
0
178
1908
0.69
1.41
5.3
5.1
1.72
2.42
mu/l
0.59
170
1781
35
488
0.67
1.40
1.3
1.3
2.07
2.05
u/ml
0.01
11
139
16
90
1.84
1.37
1.8
1.8
—
—
—
0
0
0
40
0.00
1.34
0.0
1.2
—
—
—
0
0
9
43
2.14
1.32
1.3
1.3
—
—
—
0
0
56
709
0.72
1.31
1.9
1.8
91.67
100.51
pmol/l
0.92
30
342
186
1971
0.69
1.26
11.2
11.4
18.63
19.29
mg/l
0.11
146
1500
9
169
0.51
1.24
1.1
1.1
—
—
—
0
0
19
294
0.61
1.22
2.1
1.5
—
—
—
0
0
6
127
0.46
1.21
4.3
2.1
67.33
67.42
g/l
—
6
118
8
38
2.14
1.19
5.5
3.7
—
—
—
0
0
0
33
0.00
1.17
0.0
1.2
—
—
—
0
0
0
33
0.00
1.17
0.0
5.9
—
40.78
—
0
28
10
177
0.55
1.07
2.7
1.8
—
—
—
0
0
85
986
0.78
1.02
6.7
5.6
1.97
1.92
e9/l
0.18
78
883
22
314
0.67
1.00
1.8
1.3
275.56
481.71
titre
—
9
70
9
49
1.87
1.00
2.2
2.8
—
—
—
0
0
27
192
1.46
0.98
1.6
1.5
—
—
—
0
0
0
30
0.00
0.98
0.0
1.6
—
—
—
0
0
45
562
0.75
0.93
5.8
3.0
—
—
—
0
0
9
52
1.76
0.93
1.3
1.4
—
—
—
0
0
213
2186
0.61
0.93
17.7
17.5
39.71
39.87
%
0.16
206
2072
182
1915
0.75
0.90
4.2
4.2
5.90
5.74
mmol/l
0.69
170
1792
6
31
1.96
0.85
3.7
2.5
7.70
7.46
mmol/l
—
6
31
75
640
1.26
0.84
3.1
3.1
195.55
20.15
ng/l
0.78
34
378
85
966
0.81
0.80
6.0
5.6
0.04
0.04
e9/l
0.20
76
839
20
140
1.47
0.80
1.5
1.2
—
—
—
0
0
6
33
1.84
0.79
3.7
2.5
1.43
1.27
mmol/l
—
6
33
0
25
0.00
0.79
0.0
6.7
—
—
—
0
0
0
27
0.00
0.78
0.0
1.9
—
—
—
0
0
85
963
0.81
0.77
5.9
5.6
0.52
0.53
e9/l
0.25
76
839
202
2087
0.72
0.77
13.7
13.2
67.10
67.74
umol/l
0.23
202
2087
9
56
1.63
0.73
6.3
4.2
—
—
—
0
0
19
135
1.44
0.71
3.4
2.8
—
—
—
0
0
90
1007
0.82
0.71
5.8
5.9
0.22
0.17
e9/l
1.54
80
896
7
120
0.57
0.69
1.0
1.6
1.54
1.46
g/l
—
7
109
192
1992
0.77
0.68
12.1
12.4
3.91
3.92
mmol/l
0.30
187
1939
140
1496
0.83
0.64
3.8
4.0
11.60
10.61
mm/h
0.43
134
1380
192
1989
0.78
0.63
12.1
12.3
139.84
139.90
mmol/l
0.14
187
1938
9
140
0.63
0.62
2.3
3.2
48.78
71.95
ng/l
—
9
125
173
1811
0.81
0.62
5.3
5.0
38.97
38.64
mmol/mol
0.22
162
1702
82
916
0.84
0.61
6.8
6.0
—
—
—
0
0
113
1033
1.19
0.61
3.1
3.9
6.64
6.40
mmol/l
0.51
107
959
13
185
0.68
0.61
1.1
1.3
168.73
153.19
iu/ml
—
7
85
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
125
1343
0.85
0.58
4.7
4.0
—
—
—
0
0
20
150
1.37
0.58
5.3
3.3
4.56
4.59
pmol/l
0.08
20
133
6
35
1.73
0.58
1.5
1.6
—
—
—
0
0
10
147
0.67
0.55
1.2
2.5
10.87
10.00
g/l
—
10
137
103
1120
0.85
0.54
10.4
9.3
3.95
3.86
e9/l
0.15
92
974
48
410
1.22
0.53
1.2
1.3
28.59
31.82
iu/ml
0.09
21
146
9
133
0.66
0.53
2.2
1.3
—
—
—
0
0
14
191
0.72
0.53
4.4
4.2
1.04
1.06
mmol/l
0.13
14
172
12
84
1.45
0.50
4.1
8.4
91.93
94.88
%
1.06
12
84
21
164
1.31
0.48
1.4
1.4
—
—
—
0
0
12
165
0.71
0.48
2.4
2.4
—
16.69
—
0
7
34
403
0.82
0.47
1.4
1.4
22.34
22.56
nmol/l
0.03
29
331
28
229
1.25
0.46
1.7
1.7
—
—
—
0
0
86
784
1.16
0.46
2.7
2.7
—
—
—
0
0
49
558
0.84
0.45
1.5
1.7
1.49
1.41
mmol/l
0.30
41
475
106
983
1.15
0.44
6.8
4.8
0.00
0.00
estimate
-0.00
16
189
5
31
1.63
0.43
1.4
1.4
—
—
—
0
0
6
95
0.62
0.43
1.3
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
33.00
—
0
15
0
16
0.00
0.41
0.0
1.6
—
64.00
—
0
16
52
584
0.86
0.40
2.8
2.2
49.57
58.99
u/l
1.37
46
541
0
18
0.00
0.40
0.0
2.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
3.8
—
—
—
0
0
19
235
0.79
0.39
1.2
1.3
—
—
—
0
0
106
991
1.13
0.38
4.6
3.5
0.00
0.03
estimate
0.80
15
185
142
1352
1.13
0.38
3.2
3.3
—
—
—
0
0
159
1652
0.88
0.37
4.4
4.4
14.75
14.52
pmol/l
0.59
150
1533
12
157
0.75
0.37
3.1
3.5
—
—
—
0
0
5
79
0.62
0.36
1.0
1.2
—
—
—
0
0
58
525
1.14
0.34
1.4
1.4
—
—
—
0
0
69
632
1.13
0.34
3.5
3.2
9.96
62.83
e6/l
4.18
51
417
29
248
1.19
0.34
3.8
2.6
5.58
4.01
e6/l
0.44
19
118
56
506
1.14
0.33
4.1
3.4
3.88
8.06
mg/mmol
0.79
34
285
6
87
0.68
0.33
3.5
3.2
—
7.43
—
0
14
206
2097
0.82
0.33
9.6
9.8
26.65
24.28
u/l
0.29
200
2037
22
183
1.22
0.33
1.2
1.4
—
—
—
0
0
15
120
1.27
0.31
5.3
2.7
—
—
—
0
0
57
519
1.13
0.31
2.5
2.7
6.27
6.87
mmol/l
0.38
52
439
21
249
0.83
0.31
2.0
1.9
—
—
—
0
0
8
107
0.74
0.29
1.0
1.1
—
—
—
0
0
92
865
1.11
0.28
2.1
2.0
—
—
—
0
0
41
456
0.88
0.28
3.5
1.7
1.34
0.91
mg/l
0.43
34
360
25
289
0.85
0.28
1.5
1.6
1343.05
1178.21
nmol/l
0.40
20
214
9
74
1.22
0.25
4.2
2.1
0.56
0.63
%
—
9
74
9
77
1.18
0.24
4.2
2.1
1.33
1.11
%
—
9
77
6
81
0.73
0.24
1.8
1.6
—
—
—
0
0
6
81
0.73
0.24
3.8
5.7
24.52
25.50
mmol/l
—
6
81
6
85
0.70
0.24
1.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
57.27
—
0
11
0
11
0.00
0.21
0.0
1.3
—
1.73
—
0
11
0
11
0.00
0.21
0.0
1.7
—
11.38
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
88.17
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
7.99
—
0
12
29
323
0.88
0.21
2.1
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
156.67
—
0
13
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
3.8
—
—
—
0
0
12
144
0.82
0.20
1.2
1.3
—
33.92
—
0
6
0
14
0.00
0.20
0.0
1.1
—
17.66
—
0
14
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
1.03
—
0
14
17
147
1.17
0.18
2.2
3.3
1.84
1.79
%
0.07
17
132
20
176
1.15
0.18
4.6
6.0
104.45
104.15
mmol/l
0.15
20
176
93
893
1.07
0.17
4.5
5.9
1.22
1.23
mmol/l
0.37
81
763
12
139
0.86
0.14
1.3
1.4
—
—
—
0
0
83
863
0.94
0.14
7.7
8.3
0.00
0.00
e9/l
0.72
72
702
16
180
0.88
0.13
1.9
1.3
—
—
—
0
0
62
591
1.07
0.13
3.0
2.7
—
—
—
0
0
53
558
0.93
0.13
2.0
2.0
171.79
138.23
u/l
0.23
53
532
44
465
0.93
0.12
2.3
2.6
—
—
—
0
0
22
238
0.92
0.10
1.1
1.4
—
—
—
0
0
24
223
1.09
0.09
1.1
1.4
—
—
—
0
0
5
48
1.04
0.09
1.6
2.6
—
—
—
0
0
46
480
0.95
0.09
2.7
2.9
17.20
337.22
mg/l
0.87
26
280
5
64
0.78
0.08
1.8
1.6
212.20
260.64
mu/l
—
5
55
6
72
0.83
0.07
1.8
1.2
—
—
—
0
0
100
980
1.04
0.07
4.7
3.5
0.00
0.00
estimate
-0.00
20
199
205
2064
0.93
0.07
10.9
10.7
—
—
—
0
0
10
89
1.13
0.07
4.0
4.5
—
—
—
0
0
8
93
0.86
0.07
2.5
2.4
—
—
—
0
0
196
1975
0.95
0.07
4.0
4.3
4.99
4.96
mmol/l
0.11
186
1869
190
1884
1.05
0.07
3.5
3.8
1.28
1.24
mmol/l
0.35
175
1765
22
233
0.94
0.06
1.4
1.3
—
—
—
0
0
55
534
1.04
0.06
3.6
3.7
0.00
0.00
estimate
-0.00
16
190
13
119
1.10
0.06
1.5
1.2
—
—
—
0
0
51
495
1.04
0.05
5.8
7.4
—
—
—
0
0
10
110
0.90
0.05
4.6
7.7
—
—
—
0
0
37
382
0.96
0.04
3.0
3.5
—
—
—
0
0
43
418
1.04
0.04
1.3
1.3
34.76
10.82
u/ml
0.50
14
176
15
159
0.94
0.03
1.4
2.2
0.24
0.23
g/l
0.41
15
154
199
2000
0.96
0.03
4.5
4.7
2.96
2.95
mmol/l
0.04
187
1877
75
759
0.98
0.02
13.7
8.5
1.26
1.10
inr
0.75
27
240
46
467
0.98
0.01
3.3
2.7
0.16
0.46
e6/l
1.60
37
344
16
166
0.96
0.00
1.6
1.6
—
—
—
0
0
23
236
0.97
0.00
2.7
1.8
28.96
29.66
s
0.25
23
225
50
506
0.98
0.00
3.3
2.8
11.33
76.41
e6/l
1.42
41
380
29
286
1.02
0.00
1.1
1.2
—
—
—
0
0
57
571
1.00
0.00
2.2
3.6
7.41
7.40
ph
—
8
107
51
511
1.00
0.00
3.8
3.2
—
—
—
0
0
16
163
0.98
0.00
3.6
7.0
5.41
5.22
kpa
0.61
16
158
16
163
0.98
0.00
3.6
7.0
11.08
12.39
kpa
0.53
16
158
27
273
0.99
0.00
1.3
1.2
—
—
—
0
0
196
1963
0.99
0.00
3.8
4.2
1.56
1.60
mmol/l
0.86
185
1846
171
1705
1.01
0.00
16.1
15.2
331.64
330.93
g/l
0.47
171
1696
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
17.32
—
0
5
0
6
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
1.72
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
80.17
—
0
7
0
9
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
59
1.02
-0.00
2.7
3.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
70
1.00
-0.00
2.6
2.7
8.00
1878.50
u/ml
—
7
63
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
34.8
—
109.00
—
0
6
32
320
1.00
-0.00
2.5
3.4
48.74
317.47
ng/l
0.69
19
216
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
10.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
4.52
—
0
5
5
51
0.98
-0.00
4.6
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
2217.00
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
0.27
—
0
7
5
53
0.94
-0.00
1.6
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
42.13
—
0
9
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_CERVIX_UTERI_NOS – Carcinoma in situ of uteri, other/unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).