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Carcinoma in situ of breast

DOID EFO Endpoint Browser PheWeb

CD2_INSITU_BREAST

breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

  • not C3_BREAST
285692

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D05
  • Cause of death: ICD-10 — D05
  • Cancer registry: Topography ICD-O-3 — C50
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 2

3 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

146

6. Filter based on genotype QC (FinnGen only)

128

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D00-D09
Name in latin
Carcinoma in situ vulvae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 128 128 -
Unadjusted period prevalence (%) 0.05 0.05 -
Median age at first event (years) 62.30 62.30 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
135
Matched controls
1350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
157.7
183.7
103
27
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
17.4
52.6
52
47
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
8.0
24.8
41
70
D05.9
ICD-10 Finland
Carcinoma in situ of breast, unspecified
+∞
21.4
20
*
HAB40
NOMESCO Finland
Wedge excision of mammary gland
6.9
19.3
35
65
WX402
NOMESCO Finland
General anaesthesia
4.8
17.6
60
194
HAB50
NOMESCO Finland
Partial excision of mammary gland with reconstructive operation
7.5
15.1
24
38
D05.0
ICD-10 Finland
Lobular carcinoma in situ
+∞
14.9
14
*
HAB99
NOMESCO Finland
Other partial excision of mammary gland
12.6
14.5
26
25
PJA12
NOMESCO Finland
Sentinel node biopsy
4.4
12.4
38
110
WZC15, ,
NOMESCO Finland
27.9
11.4
15
6
XX2RW, ,
NOMESCO Finland
43.6
10.1
12
*
HA1AA
NOMESCO Finland
X-ray mammography
3.9
10.0
35
110
N63
ICD-10 Finland
Unspecified lump in breast
4.3
9.9
29
80
N64.5
ICD-10 Finland
Other signs and symptoms in breast
8.4
9.7
21
29
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
7.6
8.8
20
30
YX9AW, ,
NOMESCO Finland
26.8
7.7
10
*
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
6.5
7.6
19
33
N60.8
ICD-10 Finland
Other benign mammary dysplasias
23.9
6.8
9
*
HAB00
NOMESCO Finland
Excision of lesion of mammary gland
6.8
6.7
16
26
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
3.3
6.3
26
90
XX2ET, ,
NOMESCO Finland
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
44
70
8.84
28.56
1.4
1.3
—
—
—
0
0
37
117
3.98
10.57
1.5
1.3
—
—
—
0
0
23
81
3.22
5.40
2.9
4.0
4.56
4.57
pmol/l
0.01
23
73
35
168
2.46
4.60
1.4
1.2
—
—
—
0
0
14
41
3.69
4.31
1.6
2.1
4.75
5.57
iu/l
—
7
17
94
718
2.02
3.45
7.2
9.8
3.91
3.80
e9/l
0.19
81
621
31
167
2.11
3.04
1.5
1.4
—
—
—
0
0
49
314
1.88
2.95
1.2
1.3
—
—
—
0
0
28
152
2.06
2.68
1.5
1.2
—
—
—
0
0
84
656
1.74
2.47
5.9
6.1
0.20
0.18
e9/l
0.83
76
575
53
370
1.71
2.30
2.4
2.2
—
—
—
0
0
73
562
1.65
2.15
2.5
2.6
—
—
estimate
—
0
0
17
306
0.49
2.03
3.8
3.5
1.01
1.02
kg/l
—
8
198
80
639
1.62
1.97
6.0
6.0
1.97
1.93
e9/l
0.13
75
569
54
392
1.63
1.97
5.6
5.5
—
—
—
0
0
29
179
1.79
1.90
1.6
1.6
—
—
—
0
0
27
164
1.81
1.86
1.1
1.4
—
—
—
0
0
44
311
1.62
1.76
2.0
1.7
0.62
1.08
mg/l
1.30
34
258
78
630
1.56
1.75
6.1
6.0
0.55
0.53
e9/l
0.24
71
544
78
632
1.55
1.72
6.0
6.0
0.05
0.04
e9/l
1.49
70
544
19
106
1.92
1.69
1.5
1.2
64.21
158.96
u/ml
—
8
50
71
565
1.54
1.68
10.6
10.8
0.00
0.00
e9/l
0.50
60
462
21
123
1.84
1.62
1.9
1.5
—
—
—
0
0
68
543
1.51
1.55
2.0
2.0
—
—
—
0
0
15
81
1.96
1.47
1.1
1.1
—
—
—
0
0
5
16
3.20
1.45
5.8
2.4
—
26.74
—
0
7
6
23
2.68
1.38
1.3
1.3
—
—
—
0
0
31
214
1.58
1.34
1.4
1.5
240.00
696.30
titre
—
8
54
19
118
1.71
1.23
1.3
1.5
—
—
—
0
0
8
40
2.06
1.14
1.0
1.4
—
—
—
0
0
26
182
1.53
1.06
1.2
1.2
—
—
—
0
0
15
91
1.73
1.05
3.7
5.5
—
—
—
0
0
0
28
0.00
0.99
0.0
1.2
—
125.40
—
0
20
0
28
0.00
0.99
0.0
1.0
—
29.00
—
0
19
51
416
1.36
0.93
4.0
6.7
—
—
—
0
0
6
28
2.19
0.93
1.0
1.1
—
—
—
0
0
40
315
1.38
0.90
1.4
1.4
19.87
32.04
iu/ml
—
9
113
43
524
0.74
0.87
4.0
3.6
0.00
0.02
estimate
—
8
111
73
635
1.33
0.85
5.4
6.3
1.23
1.22
mmol/l
0.09
67
554
6
32
1.91
0.83
1.0
1.2
—
—
—
0
0
10
59
1.75
0.78
1.3
1.2
—
—
—
0
0
23
169
1.44
0.76
2.4
2.4
23.79
22.49
%
0.23
23
156
11
69
1.65
0.71
1.0
1.1
—
—
—
0
0
130
1255
1.97
0.69
18.8
18.8
66.88
69.11
umol/l
1.04
130
1240
14
95
1.53
0.67
1.0
1.4
—
39.10
—
0
5
5
28
1.81
0.67
1.2
1.2
—
—
—
0
0
5
29
1.75
0.64
4.4
5.1
—
—
—
0
0
25
193
1.36
0.63
2.4
2.3
14.04
13.23
umol/l
0.27
25
182
5
30
1.69
0.62
1.2
3.1
7.43
7.43
ph
—
5
30
0
20
0.00
0.61
0.0
2.8
—
—
—
0
0
23
179
1.34
0.56
2.4
2.4
2.40
2.38
g/l
0.09
23
163
13
91
1.47
0.55
1.5
1.3
—
—
—
0
0
31
253
1.29
0.55
3.0
2.7
2.45
2.45
mmol/l
0.00
25
225
126
1217
1.53
0.55
16.3
16.2
140.06
139.98
mmol/l
0.14
126
1197
126
1219
1.50
0.55
16.6
16.3
3.93
3.94
mmol/l
0.18
126
1197
9
62
1.48
0.54
2.7
2.0
—
—
—
0
0
40
341
1.25
0.50
1.8
1.6
22.99
22.71
nmol/l
0.04
34
291
119
1144
1.34
0.45
4.3
4.3
1.21
1.24
mmol/l
0.26
114
1068
34
397
0.81
0.45
2.2
3.0
—
—
—
0
0
75
811
0.83
0.45
5.2
4.5
—
49.50
—
0
10
28
232
1.26
0.45
2.0
4.0
45.79
158.70
ng/l
0.97
19
168
5
33
1.53
0.42
1.2
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.2
—
3.98
—
0
15
0
15
0.00
0.41
0.0
2.2
—
106.87
—
0
15
0
15
0.00
0.41
0.0
2.2
—
1.19
—
0
15
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
9
66
1.39
0.39
1.2
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
62
674
0.85
0.37
4.9
3.9
0.00
0.00
estimate
-0.00
13
134
5
78
0.63
0.37
1.6
1.3
—
—
—
0
0
6
42
1.45
0.36
1.0
1.0
—
—
—
0
0
31
356
0.83
0.35
4.6
3.9
0.00
0.00
estimate
-0.00
13
129
35
396
0.84
0.33
3.5
3.3
0.00
0.01
estimate
—
10
111
41
456
0.86
0.32
3.2
3.7
11.08
170.30
ng/l
0.60
28
289
58
533
1.15
0.31
2.3
2.1
97.38
97.82
pmol/l
0.02
30
265
107
1030
1.19
0.30
18.4
18.4
13.50
13.57
%
0.27
107
1022
64
686
0.87
0.30
4.9
3.9
0.00
0.05
estimate
0.80
12
131
33
294
1.16
0.26
1.5
1.3
18.38
9.94
u/ml
0.26
17
120
11
87
1.29
0.25
1.1
1.3
—
—
—
0
0
17
143
1.22
0.24
1.3
1.4
—
—
—
0
0
49
453
1.13
0.23
3.4
4.2
117.85
52.71
e6/l
0.43
31
304
25
282
0.86
0.23
3.2
4.1
—
—
—
0
0
55
513
1.12
0.23
9.6
8.8
1.14
1.13
inr
0.04
45
423
43
395
1.13
0.23
1.9
2.2
147.33
142.39
u/l
0.04
43
380
12
98
1.25
0.22
3.6
3.6
1.22
1.23
mmol/l
0.14
12
88
121
1184
1.21
0.22
15.3
14.6
15.49
20.60
mg/l
2.10
104
935
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
49.60
—
0
10
45
416
1.12
0.21
3.0
3.7
7.40
7.40
ph
0.06
30
300
27
301
0.87
0.21
5.8
4.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
5.2
—
—
—
0
0
9
112
0.79
0.21
5.6
6.2
-0.29
1.36
mmol/l
—
9
95
11
133
0.81
0.20
1.5
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
278.33
—
0
9
0
14
0.00
0.20
0.0
2.4
—
—
—
0
0
38
351
1.11
0.18
1.5
1.3
0.70
2.79
u/ml
0.99
11
103
7
60
1.18
0.18
5.9
6.5
97.66
93.84
%
—
7
60
125
1230
1.22
0.17
11.6
12.5
—
—
—
0
0
8
69
1.17
0.17
5.9
5.1
25.07
24.89
mmol/l
—
8
69
15
130
1.17
0.16
1.3
1.3
—
—
—
0
0
8
72
1.12
0.16
1.9
2.9
—
—
—
0
0
6
77
0.77
0.16
1.0
2.4
3.45
3.90
ug/l
—
6
68
9
78
1.16
0.16
1.3
2.5
63.33
170.74
ng/l
—
9
73
41
384
1.10
0.15
4.7
3.7
9.83
6.98
mg/mmol
0.17
23
221
65
678
0.92
0.15
4.7
3.9
0.00
13.41
estimate
0.50
12
140
8
95
0.83
0.14
1.8
1.8
—
—
—
0
0
18
161
1.14
0.13
1.7
1.8
29.04
28.95
s
0.03
18
155
41
387
1.09
0.12
2.7
3.4
13.76
48.48
e6/l
1.26
30
289
40
379
1.08
0.11
4.3
3.2
31.72
27.31
mg/l
0.11
23
229
12
106
1.14
0.10
1.2
3.1
3.73
2.15
mmol/l
0.61
12
94
5
46
1.09
0.09
1.2
1.2
—
—
—
0
0
5
47
1.07
0.09
1.4
2.6
26.04
24.97
mmol/l
—
5
47
13
118
1.11
0.07
1.9
1.5
—
—
—
0
0
9
86
1.05
0.07
2.4
3.6
—
—
—
0
0
8
94
0.84
0.07
2.9
2.1
0.10
1.21
e6/l
—
8
87
50
516
0.95
0.07
3.2
3.0
—
—
—
0
0
56
576
0.95
0.06
2.2
2.0
1.44
1.34
mmol/l
0.48
51
494
41
396
1.05
0.06
4.3
3.0
6.53
6.99
mmol/l
0.28
35
339
117
1180
0.94
0.04
5.7
5.0
5.71
5.79
mmol/l
0.56
111
1113
12
111
1.09
0.04
1.2
3.1
7.40
7.40
ph
—
7
60
14
131
1.08
0.03
2.3
2.2
366.64
360.10
nmol/l
0.05
14
125
32
311
1.04
0.02
1.4
1.3
2.34
2.16
g/l
0.24
15
191
34
332
1.03
0.02
2.6
3.3
0.06
0.44
e6/l
2.35
25
232
19
184
1.04
0.00
3.3
3.1
1.36
4.18
e6/l
—
10
83
55
544
1.02
0.00
3.9
3.5
6.26
6.17
ph
0.21
29
317
11
106
1.04
0.00
1.5
2.6
9.26
10.15
g/l
0.56
11
100
12
116
1.04
0.00
1.7
1.1
—
—
—
0
0
18
184
0.97
0.00
2.3
1.6
957.46
1170.84
nmol/l
0.48
13
141
16
163
0.98
0.00
2.0
2.2
—
—
—
0
0
40
396
1.01
0.00
4.2
3.1
—
0.00
—
0
5
6
67
0.89
0.00
3.5
2.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
1.30
—
0
9
0
9
0.00
0.00
0.0
1.6
—
7.92
—
0
9
0
9
0.00
0.00
0.0
1.4
—
94.33
—
0
9
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
8
86
0.93
-0.00
1.6
1.6
0.89
1.59
g/l
—
8
79
6
68
0.88
-0.00
1.0
2.3
0.52
0.56
%
—
6
68
5
55
0.91
-0.00
1.2
1.1
0.82
0.88
g/l
—
5
55
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
30.86
—
0
7
0
6
0.00
-0.00
0.0
1.8
—
0.60
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
134.09
—
0
7
0
5
0.00
-0.00
0.0
4.0
—
52.40
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.03
—
0
5
127
1263
1.09
-0.00
13.1
12.2
24.14
24.09
u/l
0.01
127
1236
5
54
0.92
-0.00
5.0
3.2
17.60
2571.17
u/ml
—
5
48
0
5
0.00
-0.00
0.0
1.4
—
16.04
—
0
5
5
54
0.92
-0.00
1.2
1.1
1.72
1.68
g/l
—
5
54
0
8
0.00
-0.00
0.0
18.1
—
789.50
—
0
8
0
5
0.00
-0.00
0.0
2.6
—
1.00
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
15.3
—
0.66
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
69
0.86
-0.00
1.0
2.3
1.03
1.14
%
—
6
69

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_BREAST – Carcinoma in situ of breast

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).