Carcinoma in situ of breast, lobular

CD2_INSITU_BREAST_LOBULAR

breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D05.0&
  • Cause of death: ICD-10 D05.0&

2 out of 7 registries used, show all original rules.

290

4. Check minimum number of events

None

290

5. Include endpoints

None

290

6. Filter based on genotype QC (FinnGen only)

258

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D05
Name in latin
Carcinoma in situ lobulare mammae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 258 258 -
Unadjusted period prevalence (%) 0.09 0.09 -
Median age at first event (years) 58.79 58.79 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
266
Matched controls
2660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D05.0
ICD-10 Finland
Lobular carcinoma in situ
+∞
307.7
265
*
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
70.2
240.3
144
44
8500/2-C50.9
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of breast, NOS
54.8
132.0
78
20
PJA12
NOMESCO Finland
Sentinel node biopsy
10.7
86.1
143
260
HAC20
NOMESCO Finland
Total mastectomy
13.0
79.4
92
104
HAB99
NOMESCO Finland
Other partial excision of mammary gland
15.6
68.6
66
55
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
26.4
66.4
48
22
HAE10
NOMESCO Finland
Reconstruction of breast using graft or flap
20.0
63.3
52
32
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
8.2
61.5
112
216
HA1AA
NOMESCO Finland
X-ray mammography
7.6
59.1
122
267
TQW20
NOMESCO Finland
Tatoe
25.3
56.2
41
19
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
9.8
55.2
75
102
115
Kela drug reimbursment
Breast cancer
6.8
53.2
123
297
HAB40
NOMESCO Finland
Wedge excision of mammary gland
7.2
47.6
90
176
8520/2-C50.9
ICD-O-3
Lobular carcinoma in situ, NOS, of breast, NOS
241.2
41.1
41
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
6.4
40.0
84
180
D48.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Breast
15.2
39.9
37
28
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
13.7
39.4
39
33
C50.99
ICD-10 Finland
Breast, unspecified
8.4
38.6
57
84
N63
ICD-10 Finland
Unspecified lump in breast
6.6
37.9
74
147
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
9.6
35.3
45
55
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
9.3
34.3
45
57
HAB00
NOMESCO Finland
Excision of lesion of mammary gland
8.8
34.3
47
63
L02BA01
ATC
tamoxifen; oral
6.5
32.9
62
118
D05.9
ICD-10 Finland
Carcinoma in situ of breast, unspecified
352.1
31.5
31
*
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
12.0
30.1
32
30
L02BG04
ATC
letrozole; oral
4.8
28.4
81
221
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
7.6
27.7
43
66
C50
ICD-10 Finland
Malignant neoplasm of breast
7.5
27.4
43
67
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
8.9
27.1
36
46
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
5.3
26.0
62
145
HAC15
NOMESCO Finland
Subcutaneous mastectomy with excision of mamilla
29.7
25.6
34
13
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
5.2
24.8
60
142
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
5.5
23.1
50
107
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
7.2
21.5
34
53
HAE99
NOMESCO Finland
Other reconstruction of breast
26.9
21.4
29
12
Z85.3
ICD-10 Finland
Personal history of malignant neoplasm of breast
7.1
20.1
32
50
HAD30
NOMESCO Finland
Reduction mammoplasty with transposition of areola
5.7
19.2
39
78
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
7.9
18.1
26
36
D24
ICD-10 Finland
Benign neoplasm of breast
7.2
17.4
27
41
WZC00
NOMESCO Finland
Treatment plan or consultation
2.9
16.2
146
788
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
6.3
15.7
28
49
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
4.2
15.2
45
123
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
5.3
14.4
31
65
A04AA02
ATC
granisetron; systemic, transdermal
4.0
14.4
45
128
ZZR10
NOMESCO Finland
Flap of skin and muscle
17.0
14.2
22
14
H02AB02
ATC
dexamethasone; systemic
3.1
13.4
70
277
X21
ICPC
Breast sympt/compl female other
6.6
13.1
22
36
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
4.6
13.1
33
79
X76
ICPC
Malignant neoplasm breast female
5.4
12.9
27
55
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
12.8
101
496
XX3DW
NOMESCO Finland
Time consuming IT work
3.2
12.4
57
208
ZZF00
NOMESCO Finland
Graft of adipose tissue
16.9
12.3
19
12
Z31.5
ICD-10 Finland
Genetic counselling
4.1
12.3
36
97
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.7
12.2
90
425
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
4.1
12.1
36
98
HA1CG
NOMESCO Finland
Extensive MRI examination of mammary gland with high intensity magnet
6.1
11.7
21
37
C50.92
ICD-10 Finland
Malignant tumor in another specified localization in lobular gland, lobular tumor
16.4
11.0
17
11
WF003
NOMESCO Finland
Adjuvant radiotherapy
4.9
11.0
25
55
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
10.6
133
793
HA1TE
NOMESCO Finland
Supplementary or limited ultrasound examination of mammary glands
9.4
10.5
21
24
HAE05
NOMESCO Finland
Reconstruction of breast using soft tissue and prosthesis
16.9
10.5
16
10
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.8
10.2
24
54
C50.82
ICD-10 Finland
Overall malignant tumor of the mammary gland, lobular tumor
12.0
10.2
18
16
HAE00
NOMESCO Finland
Reconstruction of breast using prosthesis
21.0
9.9
14
7
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
5.1
9.7
21
44
TQB05
NOMESCO Finland
Puncture of skin of trunk
12.0
9.7
17
15
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
3.4
9.5
37
121
L02BG03
ATC
anastrozole; oral
5.1
9.2
20
42
HA4MT
NOMESCO Finland
Labeling mammary gland pathology with X-ray guidance
25.0
9.0
12
5
Z42.1
ICD-10 Finland
Follow-up care involving plastic surgery of breast
14.7
8.8
14
10
WX402
NOMESCO Finland
General anaesthesia
2.3
8.7
83
434
ZXA05
NOMESCO Finland
Left side
2.3
8.6
93
512
HAA10
NOMESCO Finland
Biopsy of mammary gland
15.1
8.3
13
9
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
4.3
8.2
22
55
HAB50
NOMESCO Finland
Partial excision of mammary gland with reconstructive operation
4.1
8.2
23
60
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
8.0
145
969
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
4.8
7.8
18
40
Z80.3
ICD-10 Finland
Family history of malignant neoplasm of breast
4.8
7.8
18
40
HAD60
NOMESCO Finland
Replacement of prosthetic implant in breast
46.4
7.8
9
*
L02BG06
ATC
exemestane; oral
4.2
7.5
20
50
HAD20
NOMESCO Finland
Liposuction of breast
82.3
7.5
8
*
N60.0
ICD-10 Finland
Solitary cyst of breast
+∞
7.3
7
*
L03AA13
ATC
pegfilgrastim; parenteral
3.0
7.2
33
119
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
3.8
7.0
22
62
8500/2-C50.4
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of upper-outer quadrant of breast
41.1
6.8
8
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
6.5
124
824
C50.00
ICD-10 Finland
Malignant tumor of nipple and areola, no histological veryfication
14.8
6.4
10
7
H03BB01
ATC
carbimazole; oral
3.7
6.4
21
61
8520/3-C50.4
ICD-O-3
Lobular carcinoma, NOS, of upper-outer quadrant of breast
8.5
6.4
13
16
Z3231
NOMESCO Finland
Registered nurse
2.0
6.4
88
523
C50.29
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland, other or undeterminated histology
11.4
6.4
11
10
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
5.3
6.3
18
36
HA1CM
NOMESCO Finland
Mammary gland extensive MRI examination with 3 Tesla magnet
27.4
6.3
8
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
91
6.06
24.15
2.7
3.9
40.11
26.88
u/ml
0.34
47
91
50
127
4.62
18.69
1.6
1.4
—
—
—
0
0
67
278
2.88
11.61
1.7
1.4
—
—
—
0
0
75
344
2.64
10.63
1.5
1.3
—
—
—
0
0
165
1166
2.09
7.71
2.8
2.5
—
—
estimate
—
0
0
125
801
2.06
7.61
2.3
2.2
—
—
—
0
0
189
1446
2.06
6.61
8.7
6.2
9.24
9.82
umol/l
0.73
179
1365
152
1111
1.86
5.72
2.8
2.2
—
—
—
0
0
14
26
5.62
5.30
1.2
1.1
—
—
—
0
0
57
317
2.02
4.83
4.8
4.2
4.63
11.15
ug/l
1.79
45
264
138
1030
1.71
4.41
4.8
3.4
2.39
2.37
mmol/l
1.95
129
934
182
1482
1.72
4.06
10.9
9.2
3.66
3.84
e9/l
0.59
158
1276
227
1993
1.95
3.68
11.2
8.1
84.91
79.10
u/l
0.63
222
1867
19
77
2.58
3.38
2.4
1.6
4.03
4.18
iu/l
—
8
30
167
1397
1.53
2.77
9.4
6.1
1.23
1.22
mmol/l
0.64
150
1188
142
1165
1.47
2.48
9.7
11.0
1.16
1.15
inr
0.06
111
941
59
404
1.59
2.42
2.9
3.1
0.84
0.81
mmol/l
0.68
59
377
58
398
1.58
2.35
3.7
3.1
2.59
3.79
e6/l
0.64
24
170
155
1309
1.44
2.23
2.8
2.5
84.52
81.53
nmol/l
0.58
145
1169
49
334
1.57
2.04
1.7
2.0
—
—
—
0
0
11
44
2.56
2.04
1.8
1.8
—
—
—
0
0
203
1822
1.48
1.99
4.2
4.2
—
0.00
—
0
6
8
27
3.02
1.95
1.1
1.1
—
—
—
0
0
82
629
1.44
1.94
3.5
3.8
—
—
—
0
0
7
22
3.24
1.89
8.4
3.0
8.26
3.10
nmol/l
—
7
22
169
1475
1.40
1.87
5.0
4.3
6.54
6.53
mmol/l
0.05
163
1399
102
819
1.40
1.86
6.5
6.0
—
—
—
0
0
83
644
1.42
1.84
4.7
3.5
99.33
95.17
%
0.88
83
629
109
890
1.38
1.78
5.4
3.7
7.39
7.40
ph
0.38
83
632
141
1202
1.37
1.76
4.7
4.1
36.28
35.92
g/l
0.32
129
1129
7
24
2.97
1.73
2.1
1.7
—
—
—
0
0
24
145
1.72
1.60
9.8
7.6
0.68
0.63
%
0.32
24
145
14
73
1.97
1.46
1.7
2.7
—
—
—
0
0
5
16
3.16
1.44
1.6
1.1
—
—
—
0
0
112
945
1.32
1.41
5.0
4.1
87.69
79.98
e6/l
0.08
71
652
24
151
1.65
1.40
9.8
7.5
1.13
1.25
%
0.43
24
151
250
2390
1.77
1.40
18.1
15.2
24.74
21.00
mg/l
0.71
212
1928
211
1953
1.39
1.36
24.5
20.4
329.27
329.90
g/l
0.51
211
1948
100
838
1.31
1.30
5.2
5.7
—
—
—
0
0
6
25
2.43
1.25
1.7
1.2
—
—
—
0
0
138
1212
1.29
1.25
5.9
6.0
28.33
28.69
%
0.14
132
1137
51
654
0.73
1.23
1.4
1.3
0.46
2.18
u/ml
1.61
11
178
5
19
2.66
1.22
1.4
1.6
—
—
—
0
0
136
1195
1.28
1.21
5.7
5.9
56.31
56.50
%
0.06
131
1125
0
35
0.00
1.16
0.0
3.3
—
—
—
0
0
142
1261
1.27
1.14
7.9
5.4
1.22
1.22
mmol/l
0.23
137
1154
133
1172
1.27
1.14
2.7
3.0
138.40
94.18
ug/l
1.00
121
1078
44
332
1.39
1.13
6.8
5.4
104.36
103.77
mmol/l
0.36
44
332
185
1700
1.29
1.11
5.2
5.1
5387.20
1361.72
e6/l
—
5
29
85
712
1.28
1.09
3.6
3.2
0.24
0.47
e6/l
0.83
52
507
8
147
0.53
1.07
1.8
2.2
0.75
0.59
%
—
8
147
8
148
0.53
1.07
1.7
2.3
1.01
1.13
%
—
8
148
135
1203
1.25
1.01
6.0
6.1
9.20
8.67
%
0.72
129
1109
61
494
1.30
1.00
4.0
4.0
72.72
146.79
ng/l
0.68
43
381
28
200
1.45
0.98
8.7
6.3
—
—
—
0
0
5
23
2.20
0.98
1.4
1.4
60.80
79.29
ng/l
—
5
23
47
369
1.33
0.96
2.4
1.7
27.82
29.14
s
1.26
47
355
0
32
0.00
0.95
0.0
1.0
—
—
—
0
0
128
1141
1.23
0.94
12.5
10.9
0.00
0.00
e9/l
0.86
104
919
73
611
1.27
0.93
3.0
2.5
2.46
2.46
mmol/l
0.09
65
556
36
273
1.37
0.92
7.8
6.4
7.43
7.42
ph
0.34
19
162
51
627
0.77
0.91
2.6
2.6
339.22
318.12
umol/l
0.78
46
538
6
30
2.02
0.87
2.2
2.7
—
—
—
0
0
13
81
1.64
0.83
1.8
1.7
753.95
207.21
ug/l
0.43
13
74
95
831
1.22
0.81
3.6
3.3
18.04
29.87
e6/l
0.73
63
633
9
151
0.58
0.81
1.2
1.4
—
—
—
0
0
133
1205
1.21
0.79
6.0
5.9
3.23
2.86
%
1.03
127
1110
0
24
0.00
0.79
0.0
1.7
—
9.47
—
0
24
25
183
1.40
0.79
1.2
1.4
—
—
—
0
0
0
28
0.00
0.76
0.0
1.3
—
—
—
0
0
32
247
1.34
0.75
5.7
3.4
1.24
1.24
mmol/l
0.01
32
209
29
221
1.35
0.73
1.8
1.6
—
—
—
0
0
75
647
1.22
0.73
1.2
1.3
—
—
—
0
0
35
275
1.31
0.73
7.9
6.4
5.01
5.21
kpa
0.68
35
270
5
26
1.94
0.71
1.0
1.8
—
—
—
0
0
5
26
1.94
0.71
1.0
1.8
—
—
—
0
0
5
26
1.94
0.71
1.0
1.8
—
—
—
0
0
5
26
1.94
0.71
1.0
1.8
—
—
—
0
0
7
41
1.73
0.70
1.0
1.0
—
—
—
0
0
132
1205
1.19
0.70
6.0
6.0
0.70
0.73
%
0.41
127
1104
33
259
1.31
0.70
2.5
2.3
28.27
29.14
u/l
0.14
26
214
250
2438
1.42
0.64
16.7
13.6
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
346.69
—
0
16
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
36
435
0.80
0.57
1.9
1.7
1111.77
1251.68
nmol/l
0.47
28
307
8
55
1.47
0.56
3.4
2.1
9.99
7.01
pmol/l
—
8
55
6
99
0.60
0.53
1.0
1.1
—
—
—
0
0
9
63
1.44
0.53
3.2
2.3
1.26
1.55
mmol/l
—
9
63
48
557
0.83
0.52
1.3
1.3
8.09
12.35
u/ml
0.34
19
215
25
200
1.28
0.48
1.7
1.2
224.11
127.68
u/ml
0.54
14
83
94
857
1.15
0.48
3.3
2.2
56.08
60.10
u/l
0.32
84
777
70
625
1.16
0.47
1.7
1.7
2.07
1.15
mg/l
0.48
63
505
40
340
1.21
0.46
1.7
1.3
—
—
—
0
0
7
49
1.44
0.46
3.9
2.6
5.69
6.93
mmol/l
—
7
49
142
1336
1.13
0.45
5.8
5.8
1.81
1.94
e9/l
0.42
120
1165
16
206
0.76
0.43
3.5
4.1
—
—
—
0
0
139
1310
1.13
0.42
5.8
5.8
0.56
0.54
e9/l
0.24
114
1108
0
16
0.00
0.41
0.0
1.8
—
157.67
—
0
16
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
48
543
0.86
0.40
1.9
1.8
146154291.82
472.98
pmol/l
0.49
39
420
5
35
1.44
0.39
1.6
1.3
—
—
nmol/l
—
0
0
0
19
0.00
0.39
0.0
1.2
—
73625.71
—
0
14
5
36
1.40
0.38
1.2
1.0
—
—
—
0
0
37
426
0.85
0.38
1.4
1.2
—
—
—
0
0
51
454
1.15
0.36
3.4
2.8
460.68
480.85
mosm/kgh2o
0.31
38
402
139
1320
1.11
0.35
5.8
5.7
0.04
0.04
e9/l
0.94
114
1115
91
976
0.90
0.33
3.6
3.7
23.96
114.41
ng/l
0.75
69
699
38
333
1.16
0.33
3.0
3.4
3.15
4.34
e9/l
2.43
33
293
78
719
1.12
0.33
3.3
3.6
0.00
0.00
estimate
-0.00
17
220
31
267
1.18
0.33
1.5
2.8
1.66
1.91
%
0.90
26
239
22
262
0.83
0.33
3.0
2.1
411.14
372.11
nmol/l
0.36
22
251
202
2076
0.89
0.32
6.0
5.0
15.17
14.92
pmol/l
0.73
188
1899
7
52
1.36
0.31
6.3
4.1
—
—
—
0
0
142
1358
1.10
0.29
5.9
5.9
0.18
0.18
e9/l
0.07
119
1169
70
649
1.11
0.27
3.7
4.2
—
0.20
—
0
5
5
73
0.68
0.26
4.2
2.4
10.52
11.19
mg/l
—
5
67
245
2415
1.18
0.26
5.3
5.4
1.66
1.62
mmol/l
0.82
227
2215
11
138
0.79
0.26
1.1
1.1
—
—
—
0
0
5
74
0.67
0.26
4.4
5.3
1.02
1.18
mmol/l
—
5
67
12
148
0.80
0.25
1.2
1.3
—
—
—
0
0
144
1387
1.08
0.24
3.9
4.3
0.00
12.37
estimate
0.80
22
283
246
2428
1.18
0.24
5.5
5.5
4.92
4.86
mmol/l
0.43
233
2241
62
576
1.10
0.23
2.3
2.6
8.54
6.56
e6/l
0.33
51
536
7
93
0.75
0.23
1.3
1.2
—
—
—
0
0
18
209
0.85
0.22
1.4
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
90.22
—
0
11
0
11
0.00
0.21
0.0
1.2
—
55.27
—
0
11
0
11
0.00
0.21
0.0
1.0
—
544.17
—
0
6
0
10
0.00
0.21
0.0
2.6
—
0.80
—
0
5
0
12
0.00
0.21
0.0
1.3
—
63.41
—
0
7
0
12
0.00
0.21
0.0
1.3
—
132.72
—
0
12
143
1382
1.08
0.21
3.9
4.2
0.00
0.00
estimate
-0.00
22
273
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
0.11
—
0
7
96
915
1.08
0.20
3.1
3.1
6.43
6.55
mmol/l
0.11
83
754
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
67.00
—
0
14
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
38
347
1.11
0.20
2.0
2.3
92.90
132.07
ug/g
0.72
29
278
6
50
1.20
0.20
1.0
1.1
—
—
—
0
0
116
1204
0.94
0.19
2.2
2.1
96.24
99.90
pmol/l
0.38
49
545
145
1406
1.07
0.19
3.9
4.3
0.00
0.00
estimate
-0.00
20
267
238
2351
1.12
0.18
7.1
6.2
1.82
1.92
mu/l
0.65
224
2163
7
62
1.13
0.17
3.1
5.3
3.91
3.77
mmol/l
—
7
62
75
788
0.93
0.17
3.4
4.5
0.00
0.00
estimate
-0.00
21
265
5
68
0.73
0.17
2.6
3.1
62.40
59.60
%
—
5
68
25
225
1.12
0.17
2.4
2.6
6.23
6.12
ph
0.15
13
153
8
71
1.13
0.16
5.9
10.1
—
—
—
0
0
44
410
1.09
0.16
2.3
2.4
13.26
12.78
umol/l
0.18
39
383
8
73
1.10
0.16
1.0
1.0
—
—
—
0
0
57
602
0.93
0.15
1.3
1.4
26.25
32.19
iu/ml
0.22
19
202
52
550
0.93
0.14
2.1
1.5
1.91
2.35
g/l
1.37
25
315
18
201
0.89
0.14
1.2
1.3
—
—
—
0
0
21
232
0.90
0.14
4.3
4.5
1.00
0.66
%
—
7
62
22
242
0.90
0.13
4.2
4.5
1.00
0.92
%
—
7
71
9
106
0.84
0.13
3.7
2.7
25.24
25.30
mmol/l
—
9
106
21
231
0.90
0.13
4.3
4.6
0.17
0.16
%
—
6
60
20
220
0.90
0.12
2.8
2.4
0.22
0.24
e6/l
0.07
20
203
26
240
1.09
0.11
1.8
1.5
—
—
—
0
0
248
2462
1.11
0.11
6.2
6.4
2.77
2.79
mmol/l
0.13
232
2264
40
378
1.07
0.11
2.2
2.4
2.39
2.38
g/l
0.03
35
353
92
893
1.05
0.10
3.1
3.2
22.25
28.18
mg/l
0.22
62
498
5
44
1.14
0.10
1.6
1.1
—
—
—
0
0
5
45
1.11
0.10
1.0
1.3
—
—
—
0
0
5
46
1.09
0.09
1.4
1.7
—
—
—
0
0
10
87
1.16
0.09
1.2
1.4
—
—
—
0
0
5
47
1.07
0.09
1.2
1.2
—
—
—
0
0
5
47
1.07
0.09
1.4
1.4
—
—
—
0
0
62
598
1.05
0.09
3.2
4.7
—
—
—
0
0
24
257
0.93
0.09
1.6
1.5
—
—
—
0
0
6
55
1.09
0.09
1.3
1.9
—
—
—
0
0
121
1186
1.04
0.08
2.0
1.9
1.23
1.32
mmol/l
0.93
96
971
7
65
1.08
0.08
1.9
1.7
5.32
4.90
mmol/24h
—
7
55
6
74
0.81
0.07
6.5
2.4
2.01
1.42
mg/l
—
6
62
243
2415
1.07
0.07
5.7
5.5
5.83
5.86
mmol/l
0.20
226
2204
10
112
0.89
0.07
2.6
1.8
—
—
—
0
0
8
91
0.88
0.07
1.4
3.3
—
—
—
0
0
22
208
1.06
0.05
1.8
2.8
64.25
75.02
e9/l
1.19
15
147
10
110
0.91
0.05
1.1
1.1
—
—
—
0
0
92
904
1.03
0.05
3.8
3.9
7.75
6.69
mg/mmol
0.09
59
484
93
917
1.02
0.03
3.8
3.4
—
—
—
0
0
102
1032
0.98
0.03
3.4
4.1
0.00
0.00
estimate
0.50
16
215
160
1588
1.02
0.03
4.3
3.1
68.44
44.46
u/l
1.07
144
1476
27
262
1.03
0.02
1.5
1.4
—
—
—
0
0
10
93
1.08
0.02
2.4
1.5
0.40
3.93
ug/l
—
10
87
10
107
0.93
0.02
1.3
1.2
—
2.02
—
0
14
23
237
0.97
0.01
4.3
4.9
0.14
0.10
%
—
7
52
230
2307
0.98
0.01
4.5
4.5
1.25
1.26
mmol/l
0.05
210
2096
10
94
1.07
0.01
3.4
2.3
1.82
1.49
g/l
—
10
84
33
324
1.02
0.00
1.8
1.4
—
—
—
0
0
81
804
1.01
0.00
1.7
1.7
23.81
22.34
nmol/l
0.38
70
671
91
916
0.99
0.00
3.9
3.2
—
—
—
0
0
15
152
0.99
0.00
1.4
1.2
—
—
—
0
0
23
228
1.01
0.00
1.6
1.3
—
—
—
0
0
14
139
1.01
0.00
2.3
1.9
—
—
—
0
0
41
411
1.00
0.00
1.4
1.4
476.36
655.19
titre
0.34
11
108
62
621
1.00
0.00
2.9
4.5
1.02
1.02
kg/l
0.13
42
409
64
639
1.00
0.00
2.2
2.2
2.61
3.11
mg/l
1.09
54
545
112
1116
1.01
0.00
3.5
3.7
6.21
6.27
ph
0.20
53
611
27
267
1.01
0.00
1.6
1.7
—
—
—
0
0
21
213
0.98
0.00
5.4
2.5
65.34
67.32
g/l
0.58
21
200
235
2345
1.02
0.00
6.9
6.6
38.87
39.03
mmol/mol
0.14
221
2185
19
186
1.02
0.00
6.0
2.5
—
—
—
0
0
24
245
0.98
0.00
2.8
3.1
7.37
7.39
ph
0.80
17
130
14
145
0.96
0.00
3.4
2.4
—
—
—
0
0
12
125
0.96
0.00
1.4
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
0.00
—
0
9
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
58.40
—
0
5
0
5
0.00
-0.00
0.0
4.8
—
6.20
—
0
5
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
5
56
0.89
-0.00
4.2
2.8
8.34
7.94
kpa
—
5
56
0
6
0.00
-0.00
0.0
21.3
—
1025.50
—
0
6
5
51
0.98
-0.00
1.6
3.2
4.66
4.55
e9/l
—
5
51
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
5.25
—
0
6
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
1825.86
—
0
7
0
5
0.00
-0.00
0.0
1.8
—
21.92
—
0
5
5
56
0.89
-0.00
1.6
1.2
0.91
0.91
g/l
—
5
56
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
73
0.96
-0.00
2.7
2.6
25.10
25.53
mmol/l
—
7
73
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_BREAST_LOBULAR – Carcinoma in situ of breast, lobular

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).