breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.
Carcinoma in situ of breast, other/unspecified
DOID EFO Endpoint Browser PheWeb
CD2_INSITU_BREAST_NOS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleonly females |
293145 |
2. Check conditionsNone |
293145 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
505 |
4. Check minimum number of eventsNone |
505 |
5. Include endpointsNone |
505 |
6. Filter based on genotype QC (FinnGen only) |
485 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 485 | 485 | - |
| Unadjusted period prevalence (%) | 0.17 | 0.17 | - |
| Median age at first event (years) | 58.85 | 58.85 | - |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 505
- Matched controls
- 5050
TimeCodeWAS
↥TODO / Current known limitations:
- Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
- Legend / how to read the glyphs.
- Proper column names.
- Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
- Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
- Download CSV not working.
- No filters and sorters.
- Limited amount of endpoints with TimeCodeWAS data.
- Cross-links to Risteys lab test pages for lab test codes.
D05.9 (45537885)
D05.7 (45561889)
D05.0 (45571586)
2330A (2000402181)
HAB00 (2001303924)
HAB99 (2001303930)
SMOKING-2-3-0 (2002330113)
50373000 (4177340)
60621009 (4245997)
98278-5 (1617658)
HA6AA (2001303914)
HAB40 (2001303928)
HAB50 (2001303929)
HAC15 (2001303933)
HAE10 (2001303956)
HA4AT (2001303990)
PJA12 (2001309627)
PJD52 (2001309638)
TQB05 (2001309838)
6875-9 (3006588)
117617002 (4035726)
66110-8 (40768793)
8503/2-C50.9 (44501731)
8500/2-C50.9 (44505314)
D05.1 (45576374)
N63 (45601743)
9703 (2000101652)
9707 (2000101656)
C50.11 (2000500990)
C50.49 (2000501004)
C50.90 (2000501017)
C50.99 (2000501021)
HA1AA (2001303884)
HA1AE (2001303886)
HAC20 (2001303934)
HAD30 (2001303943)
HAE20 (2001303957)
HA003 (2001303965)
ZXA00 (2001311346)
ZXE10 (2001311401)
890-4 (3001079)
882-1 (3003694)
261QX0200X (38004268)
2 (38004447)
8500/2-C50.4 (44502954)
Z85.3 (45547353)
C50.4 (45561816)
N60.9 (45567853)
21 (8717)
IP (9201)
24 (38004467)
90 (38004507)
C50.41 (2000501002)
OP (9202)
ZXD10 (2001311387)
ZXE00 (2001311394)
66121-5 (40768804)
R4110 (2001310233)
WX404 (2001310807)
C50 (45571518)
OMOP5117446 (33004)
34531-4 (3044640)
22 (8756)
77397-8 (46236098)
WZC00 (2001310885)
8500/3-C50.9 (44505315)
30385-9 (3002385)
62238-1 (40764999)
115 (2001600115)
B01AB05 (21600976)
H02AB02 (21602730)
28540-3 (3003338)
26515-7 (3007461)
28539-5 (3035941)
30428-7 (3024731)
26453-1 (3026361)
20570-8 (3009542)
718-7 (3000963)
26464-8 (3010813)
58410-2 (40761511)
OMOP4822461 (32036)
14682-9 (3020564)
A03FA01 (21600484)
14631-6 (3006140)
2823-3 (3023103)
2951-2 (3019550)
55429-5 (40758558)
ZX012 (2001311468)
25 (38004468)
L02BG04 (21603842)
L02BA01 (21603831)
251B00000X (38004193)
A04AA02 (21600494)
WX110 (2001310767)
2000-8 (3015377)
J01DB01 (21602870)
WX408 (2001310808)
34534-8 (3044889)
6768-6 (3035995)
24419-4 (3002256)
R02AX02 (1588667)
M01AE01 (21603967)
WB113 (2001310629)
751-8 (3013650)
HAE99 (2001303958)
C50.91 (2000501018)
N02BE01 (21604344)
N06AX16 (21604745)
Z31.5 (45590715)
OMOP4822000 (32411)
LabWAS
↥Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: CD2_INSITU_BREAST_NOS – Carcinoma in situ of breast, other/unspecified
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).