Benign neoplasm: Prostate

CD2_BENIGN_PROSTATE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule only males	244368
2. Check conditions None	244368
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D29.1& Hospital discharge: ICD-9 — 2222 Cause of death: ICD-10 — D29.1& Cause of death: ICD-9 — 2222 2 out of 7 registries used, show all original rules.	260
4. Check minimum number of events None	260
5. Include endpoints None	260
6. Filter based on genotype QC (FinnGen only)	240

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D29
Name in latin: Neoplasma benignum prostatae

NAME	CD2_BENIGN_PROSTATE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	1
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D291
HD_ICD_9	2222
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D291
COD_ICD_9	2222
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Prostate based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1360	-	1360
Only index persons	1120	-	1120
Unadjusted period prevalence (%)
Whole population	0.04	-	0.04
Only index persons	0.04	-	0.04
Median age at first event (years)
Whole population	-	-	71.01
Only index persons	-	-	69.61

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	240	-	240
Unadjusted period prevalence (%)	0.11	-	0.11
Median age at first event (years)	68.24	-	68.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
247: Matched controls
2470

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D29.1

ICD-10 Finland

Benign neoplasm: Prostate

4503599627370496.0

307.7

244

C61

ICD-10 Finland

Malignant neoplasm of prostate

4.9

33.6

115

372

8140/3-C61.9

ICD-O-3

Adenocarcinoma, NOS, of prostate gland

4.7

31.3

109

354

NK6AN

NOMESCO Finland

Total body bone isotope imaging

10.1

29.7

JN3CD

NOMESCO Finland

Abdominal CT examination both without and with contrast

8.2

29.0

ZXC96

NOMESCO Finland

Robot assisted procedure

10.5

29.0

KEC01

NOMESCO Finland

Percutaneous endoscopic radical prostatectomy

8.5

27.1

KE1BE

NOMESCO Finland

Rectal ultrasound examinaiton of prostata

3.4

17.2

319

116

Kela drug reimbursment

Prostate cancer

3.6

15.3

206

XJH00

NOMESCO Finland

Transanal ultrasonography

3.3

12.2

199

UKC02

NOMESCO Finland

Cystoscopy

2.5

10.7

483

Y77

ICPC

Malignant neoplasm prostate

3.7

10.2

101

KE1AT

NOMESCO Finland

Biopsy of prostata with ultrasoudnguidance

2.9

9.8

212

XKD00

NOMESCO Finland

Uroflowmetry

2.4

9.5

103

576

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

3.0

9.2

182

N40

ICD-10 Finland

Hyperplasia of prostate

2.3

8.8

154

1042

KC1EE

NOMESCO Finland

Ultrasound measurement of residual urine

2.3

8.1

486

PJD64

NOMESCO Finland

Laparoscopic dissection of iliac lymph nodes

9.9

7.9

G04CB01

ATC

finasteride; oral

2.2

7.6

482

SPAT1220

SPAT

Assessment of need for rehabilitation and/or rehabilitation plan

3.6

7.5

WW200, ,

SPAT

2.2

7.3

512

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.0

6.4

152

1099

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

289

3.96

21.87

6.0

5.2

32.42

31.33

0.31

187

(3019225) pH of Specimen

224

3.29

13.31

6.7

4.1

7.31

7.35

0.83

165

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

266

2.54

8.11

9.8

9.1

—

(3045414) Leukocytes [Presence] in Urine

179

2.77

7.79

2.2

2.1

0.00

estimate

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

3.35

7.74

1.8

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

112

3.02

6.77

5.7

4.8

23.65

25.12

mmol/l

1.78

105

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

107

3.05

6.70

1.9

2.0

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

203

1655

2.27

5.85

9.1

6.2

2.96

2.89

ug/l

0.03

174

1468

(3017732) Neutrophils [#/volume] in Blood

259

2.17

5.17

2.6

3.0

4.55

5.36

e9/l

0.38

218

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

481

1.91

4.98

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

120

869

1.74

4.39

2.4

2.2

—

(40761535) Cells panel - Urine sediment

184

2.19

4.21

4.1

3.6

—

(3022313) Gas panel - Capillary blood

152

2.27

4.06

5.8

3.9

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

140

2.30

3.96

1.9

2.0

1.91

2.12

ug/l

0.06

119

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

150

1178

1.70

3.91

4.3

3.4

56.15

63.86

u/l

0.57

137

1097

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

134

1025

1.67

3.83

2.4

2.3

101.22

89.75

pmol/l

1.52

607

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

180

2.10

3.66

5.4

4.0

0.29

1.98

mmol/l

1.46

137

(3009343) pH of Capillary blood

209

2.03

3.66

5.7

3.8

7.41

7.42

0.23

169

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

108

791

1.65

3.59

2.2

77.08

75.38

nmol/l

0.26

685

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

214

1.98

3.43

5.7

3.8

4.82

5.11

kpa

1.52

208

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

4.06

3.33

3.1

2.8

—

(40768804) Tissue Pathology biopsy report

102

755

1.60

3.15

2.5

2.4

—

(4146454) Self-monitoring of blood glucose

3.79

3.12

2.6

2.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.85

3.04

1.6

1.4

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

2.30

2.93

2.4

3.6

1.22

3.51

ratio

1.41

(1761868) Lipid panel - Serum or Plasma

579

0.54

2.93

2.5

3.7

—

(3044640) Blood type and Crossmatch panel - Blood

101

757

1.57

2.91

2.6

2.7

—

(3049717) Cytology report of Urine Cyto stain

152

2.03

2.90

3.0

3.3

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

118

2.15

2.83

3.7

3.0

3.81

3.69

g/l

0.12

104

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

118

2.15

2.83

3.7

3.0

7.14

7.31

g/l

0.19

104

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

118

2.15

2.83

3.7

3.0

4.09

4.15

g/l

0.12

104

(3021589) Normoblasts [#/volume] in Blood

915

0.62

2.79

9.9

13.3

0.00

e9/l

0.63

747

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

559

1.58

2.69

2.5

2.6

—

(42870588) Differential panel, method unspecified - Blood

740

1.54

2.68

5.6

5.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

203

1.84

2.62

4.6

2.8

—

(3023368) Bacteria identified in Blood by Culture

107

827

1.52

2.62

4.3

4.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

140

1145

1.51

2.61

9.6

8.0

1.19

1.20

mmol/l

0.18

115

1001

(3020876) Protein [Mass/time] in 24 hour Urine

3.15

2.60

2.2

2.4

0.82

1.26

g/24h

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.18

2.51

3.5

3.4

10.34

11.04

g/l

0.22

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

129

1045

1.49

2.47

8.4

7.2

1.20

mmol/l

0.27

110

959

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

104

2.11

2.44

2.0

3.3

1.01

0.94

g/l

0.03

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

189

1664

1.58

2.39

4.8

4.3

2.01

2.09

mu/l

0.29

155

1462

(4024509) Urine culture

2.13

2.39

2.4

1.9

—

(40761536) Microorganisms panel - Urine sediment

172

0.33

2.38

8.2

3.8

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

4.21

2.37

1.3

1.4

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

4.21

2.37

1.3

1.4

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

113

2.04

2.34

1.9

3.1

2.61

3.08

g/l

1.41

(3025468) Yersinia sp identified in Specimen by Organism specific culture

3.30

2.33

1.8

1.7

—

(3006504) Eosinophils/Leukocytes in Blood

121

978

1.47

2.29

5.5

6.0

2.58

2.88

0.89

106

917

(3022096) Basophils/Leukocytes in Blood

121

978

1.47

2.29

5.6

6.1

0.63

0.58

0.38

106

920

(3017704) Immunofixation for Urine

4.70

2.28

2.8

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

3.18

2.25

1.8

1.7

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

3.18

2.25

1.8

1.7

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

3.18

2.25

1.8

1.7

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

3.18

2.25

1.8

1.7

—

(3019069) Monocytes/Leukocytes in Blood

121

982

1.46

2.22

5.7

6.1

9.30

9.43

0.18

106

918

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

113

906

1.46

2.21

3.5

3.6

1643.73

1753.13

ng/l

0.16

798

(3013826) Glucose [Moles/volume] in Serum or Plasma

159

1361

1.47

2.20

4.8

5.7

6.64

7.01

mmol/l

2.11

153

1319

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.24

2.20

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

410

0.54

2.19

5.3

5.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.37

2.19

1.6

1.5

—

(3018010) Neutrophils/Leukocytes in Blood

120

975

1.45

2.18

5.3

6.0

61.07

59.76

0.63

106

929

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

4.36

2.16

1.3

1.4

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

4.36

2.16

1.3

1.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

199

1788

1.58

2.15

5.6

4.09

4.13

mmol/l

0.23

164

1626

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

123

1008

1.44

2.11

2.9

3.0

—

estimate

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

5.08

2.08

1.2

1.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

419

1.54

2.08

4.1

3.4

0.77

1.09

e6/l

0.61

252

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.57

2.04

1.5

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

202

1830

1.57

2.00

6.4

2.36

2.37

mmol/l

0.08

170

1654

(3013115) Eosinophils [#/volume] in Blood

130

1084

1.42

1.99

5.4

6.0

0.20

0.21

e9/l

0.40

106

941

(3019832) Treponema pallidum Ab [Presence] in Serum

2.42

1.98

1.5

1.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

118

968

1.42

1.98

4.9

3.5

0.74

0.83

ug/l

0.77

694

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

205

1866

1.58

1.96

24.6

21.4

29.75

30.50

mg/l

0.11

182

1637

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

3.03

1.95

1.8

1.7

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

3.82

1.94

1.2

1.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

197

1782

1.52

1.89

6.1

5.5

1.31

1.30

mmol/l

0.15

165

1604

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

120

1407

0.71

1.86

30.9

28.5

332.58

332.66

g/l

0.03

120

1400

(3021960) Folate [Moles/volume] in Serum or Plasma

738

1.42

1.85

1.9

1.8

15.93

18.73

nmol/l

1.18

606

(40760888) Immunoglobulin light chains.free panel - Serum

2.23

1.81

3.3

4.1

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.40

1.80

1.5

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

171

1.72

1.80

1.8

1.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

560

0.64

1.79

4.9

3.7

0.00

0.15

estimate

0.58

183

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

118

981

1.39

1.78

4.9

4.8

33.54

47.51

ng/l

1.16

821

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

3.39

1.75

1.2

1.1

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

173

1.70

1.73

1.9

1.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

199

1815

1.50

1.72

6.6

5.9

6.06

6.22

mmol/l

1.22

163

1627

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

3.90

1.72

1.0

1.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

471

1.45

1.72

1.8

1046.32

1145.48

nmol/l

0.31

366

(3019550) Sodium [Moles/volume] in Serum or Plasma

211

1949

1.57

1.71

30.5

26.4

139.51

139.60

mmol/l

0.19

204

1924

(3001122) Ferritin [Mass/volume] in Serum or Plasma

105

862

1.38

1.68

3.1

3.0

185.37

192.13

ug/l

0.09

793

(3023103) Potassium [Moles/volume] in Serum or Plasma

211

1951

1.56

1.68

30.7

26.6

4.03

4.06

mmol/l

0.66

204

1927

(3024731) MCV [Entitic mean volume] in Red Blood Cells

213

1974

1.57

1.67

35.9

32.1

91.76

92.24

0.69

208

1956

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

213

1975

1.57

1.66

36.2

32.9

39.92

39.99

0.06

208

1954

(3000963) Hemoglobin [Mass/volume] in Blood

213

1975

1.57

1.66

36.1

32.4

133.75

134.81

g/l

0.38

208

1955

(3026361) Erythrocytes [#/volume] in Blood

213

1975

1.57

1.66

36.0

32.1

4.43

4.44

e12/l

0.07

201

1935

(3010813) Leukocytes [#/volume] in Blood

213

1975

1.57

1.66

36.0

32.2

7.32

7.18

e9/l

0.42

203

1936

(3007461) Platelets [#/volume] in Blood

213

1975

1.57

1.66

36.0

32.2

230.07

223.80

e9/l

0.73

204

1940

(3035941) MCH [Entitic mass]

213

1975

1.57

1.66

35.9

32.0

30.45

30.70

0.94

208

1956

(3002030) Lymphocytes/Leukocytes in Blood

118

991

1.37

1.63

5.6

6.2

23.05

24.32

0.65

108

937

(3020564) Creatinine [Moles/volume] in Serum or Plasma

212

1966

1.55

1.62

32.9

29.1

99.25

93.88

umol/l

1.09

206

1950

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

3.05

1.59

1.3

1.2

—

(3025941) Bacteria identified in Stool by Culture

1.98

1.58

1.1

1.3

—

(3037756) Immunofixation for Serum or Plasma

2.09

1.57

2.3

1.3

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

2.47

1.55

3.0

5.2

—

(3044290) Cell count panel - Cerebral spinal fluid

2.47

1.55

1.1

1.3

—

(3001604) Monocytes [#/volume] in Blood

124

1056

1.35

1.54

5.3

5.9

0.65

e9/l

0.06

104

895

(3020630) Protein [Mass/volume] in Serum or Plasma

245

1.55

1.54

4.5

3.3

65.39

66.11

g/l

0.23

222

(3014271) Vancomycin [Susceptibility]

2.90

1.51

3.2

2.3

—

(3006315) Basophils [#/volume] in Blood

124

1061

1.34

1.47

5.3

5.9

0.04

e9/l

0.29

103

904

(3019198) Lymphocytes [#/volume] in Blood

125

1073

1.33

1.44

5.4

6.1

1.63

1.81

e9/l

1.22

103

943

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

189

1728

1.40

1.43

4.9

4.7

1.24

1.28

mmol/l

0.33

151

1548

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

176

1591

1.37

1.43

9.8

9.3

79.67

83.98

u/l

0.54

169

1512

(3023520) Reticulocytes [#/volume] in Blood

295

1.47

1.36

2.2

2.5

66.95

64.65

e9/l

0.21

229

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

172

0.51

1.35

4.3

1.23

1.21

mmol/l

—

151

(3032080) INR in Blood by Coagulation assay

143

1261

1.32

1.33

21.0

19.5

1.33

1.39

inr

0.65

117

1071

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

359

1.42

1.30

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

281

1.46

1.29

2.0

1.8

—

(21494890) Protein electrophoresis panel - 24 hour Urine

2.20

1.22

1.5

2.5

—

(3016018) Differential panel - Cerebral spinal fluid

2.66

1.22

1.0

1.1

—

(40761511) CBC panel - Blood by Automated count

201

1875

1.39

1.19

23.2

19.7

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

194

1801

1.36

1.18

24.1

21.2

68.04

72.38

ml/min/173m2

2.03

176

1704

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

393

1.38

1.17

2.8

2.7

21.63

22.53

0.15

366

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

143

1.59

1.16

1.3

1.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

403

1.37

1.15

3.8

3.5

2.29

0.62

e6/l

0.64

235

(40768800) Prostate Pathology biopsy report

111

1.67

1.15

1.0

1.1

—

(3026493) Urate [Moles/volume] in Serum or Plasma

606

1.32

1.14

3.6

3.3

375.39

380.02

umol/l

0.15

525

(3017446) Testosterone [Moles/volume] in Serum or Plasma

288

1.42

1.14

2.4

2.5

10.67

12.60

nmol/l

0.59

247

(42529406) Shigella sp [Presence] in Stool by Culture

2.03

1.13

1.1

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.03

1.13

1.1

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.03

1.13

1.1

1.2

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

424

1.35

1.11

2.6

2.7

2.12

2.19

g/l

0.53

392

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

187

1.50

1.09

1.7

1.5

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

162

1474

1.29

1.09

5.6

4.4

14.40

14.25

mm/h

0.03

148

1362

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.22

1.09

1.3

—

(3037522) Nuclear Ab [Titer] in Serum

213

1.46

1.08

1.2

226.67

382.11

titre

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

132

1174

1.27

1.06

7.1

10.2

4.90

4.44

e9/l

1.16

114

1021

(3017143) Hepatitis C virus Ab [Presence] in Serum

164

1.51

1.04

1.9

1.6

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

191

1781

1.32

1.03

8.2

7.8

40.22

41.10

mmol/mol

0.61

152

1641

(36660697) Celiac disease serology panel - Serum

108

1.62

0.99

1.7

1.3

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

100

1.64

0.99

1.8

2.4

0.29

0.37

iu/ml

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

245

1.40

0.95

2.0

2.5

4.81

7.15

ug/l

0.74

216

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

1.92

0.95

1.1

1.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

146

1325

1.25

0.94

5.7

5.1

19.30

21.77

1.41

726

(3002256) Pathology report gross observation

299

1.36

0.94

1.3

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

143

1.51

0.93

1.5

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

103

901

1.25

0.92

4.6

3.7

—

(3022948) Iron [Moles/volume] in Serum or Plasma

456

1.29

0.90

2.8

2.7

11.14

12.43

umol/l

0.56

424

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

2.09

0.90

1.2

1.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

248

1.38

0.89

1.3

13.44

39.84

iu/ml

—

(3044927) Protein electrophoresis panel - Urine

2.02

0.87

1.3

1.1

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

665

1.25

0.87

2.2

3.20

2.99

mg/l

0.27

576

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

1.96

0.85

2.5

1.5

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

1.96

0.85

1.2

2.1

—

(3000093) Morphology [Interpretation] in Blood Narrative

1.90

0.82

1.0

1.2

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

148

1.46

0.81

1.4

1.88

1.53

g/l

0.67

135

(3011397) Hemoglobin [Presence] in Urine by Test strip

472

1.27

0.81

4.7

4.0

—

0.44

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

804

0.80

4.9

4.3

0.00

0.05

estimate

1.32

206

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

444

0.75

0.80

1.7

1.34

1.74

mg/l

0.52

362

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.69

0.79

1.1

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

227

1.37

0.79

1.3

1.14

18.83

u/ml

—

(3004775) Volume in Urine collected for unspecified duration

0.00

0.78

0.0

2.1

—

492.50

—

(3015736) pH of Urine

827

1.22

0.77

4.1

3.7

6.10

6.17

0.25

460

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

203

1932

1.28

0.77

15.1

13.6

24.85

26.04

u/l

0.38

189

1877

(46235355) HIV 1 and 2 tests - Meaningful Use set

221

1.35

0.74

2.1

1.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

273

0.71

0.73

5.1

3.6

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.65

0.73

1.5

1.4

—

(3027945) Reticulocytes/Erythrocytes in Blood

376

1.27

0.72

2.1

2.3

1.78

1.71

0.21

336

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.56

0.70

1.5

1.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.65

0.67

1.0

1.2

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

1.80

0.66

1.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

336

1.26

0.64

1.7

1.9

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

1.74

0.64

1.2

2.2

—

(3026008) Bacteria identified in Urine by Culture

628

1.21

0.64

3.6

3.4

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.50

0.62

1.1

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

123

1.41

0.59

2.1

2.5

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.59

0.0

1.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

140

1301

1.18

0.59

3.3

15.48

15.03

pmol/l

1.25

113

1136

(3021601) Nitrite [Presence] in Urine by Test strip

114

1042

1.17

0.59

4.4

4.1

0.00

estimate

-0.00

243

(3003327) Ova and parasites identified in Stool by Light microscopy

1.68

0.57

1.5

1.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

113

1036

1.17

0.56

5.4

5.6

34.10

34.17

g/l

0.04

976

(3009261) Glucose [Presence] in Urine by Test strip

116

1066

1.17

0.55

4.8

4.1

0.00

1.33

estimate

0.51

229

(3000494) Fungus identified in Specimen by Culture

262

1.25

0.52

1.3

1.5

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.51

0.50

1.5

1.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

722

1.16

0.48

1.8

2.0

1.28

1.26

mmol/l

0.09

568

(3035350) Ketones [Presence] in Urine by Test strip

114

1056

1.15

0.47

4.8

4.1

0.00

0.01

estimate

0.50

248

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

156

1.31

0.47

3.0

4.3

23.34

23.73

mmol/l

0.42

156

(4034850) Laboratory test

1.47

0.45

26.4

13.9

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

1.63

0.43

1.0

1.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.39

0.42

1.0

1.1

—

(3022806) Fractional oxyhemoglobin in Capillary blood

1.53

0.41

4.6

1.5

90.52

88.82

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.41

0.0

1.1

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.4

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.41

0.0

1.2

—

(3016750) Collection duration of Urine

0.00

0.40

0.0

2.3

—

508.33

—

(4268621) Lupus anticoagulant assay

0.00

0.40

0.0

2.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

741

1.14

0.40

2.2

4.0

2.32

2.33

mmol/l

0.09

663

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.43

0.40

1.6

1.7

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.39

0.0

1.3

—

5.25

—

(3039443) Prostate specific Ag panel - Serum or Plasma

1.36

0.38

1.4

1.7

—

(40758558) Short blood count panel - Blood

588

1.14

0.37

6.5

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

1.37

0.37

1.4

3.7

0.00

g/l

-0.00

(3008037) Lactate [Moles/volume] in Venous blood

0.62

0.36

2.6

3.8

1.64

1.59

mmol/l

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

1.40

0.35

1.5

2.0

—

(3012516) Albumin [Mass/volume] in Urine

814

0.89

0.35

4.7

3.6

101.50

71.91

mg/l

0.23

576

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

660

1.13

0.34

3.0

3.3

35.82

38.76

u/l

0.18

625

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

1.36

0.31

1.1

1.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.30

0.30

1.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

838

0.90

0.30

5.3

4.4

23.54

11.27

mg/mmol

0.45

567

(1002224) Polysomnography panel

1.23

0.29

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

181

0.82

0.26

1.7

1.5

—

(3000991) Gas panel - Venous blood

245

1.16

0.26

5.3

9.8

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

236

1.16

0.25

3.2

2.9

0.36

0.41

e6/l

0.09

229

(3022145) Colonoscopy Study observation

236

1.16

0.25

1.2

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

125

1.21

0.23

1.9

3.3

—

(3035933) Granulocytes/Leukocytes in Blood

1.29

0.23

4.8

2.7

60.04

57.59

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.21

0.0

1.2

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

91.91

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.4

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

27.70

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

2.8

—

1.17

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.21

0.0

4.4

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

1.23

0.20

1.7

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

109

1.20

0.19

1.1

1.5

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

1.21

0.18

1.1

1.8

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.19

0.18

1.6

—

(3000330) Specific gravity of Urine by Test strip

110

1.19

0.17

2.5

4.7

1.02

ratio

0.09

105

(4035726) Immunohistochemistry procedure

197

1.13

0.16

1.3

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.78

0.16

2.0

1.6

—

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

178

1.13

0.15

5.7

3.1

44.82

55.94

ml/min/173m2

1.57

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

161

0.86

0.15

3.7

4.2

62.99

47.56

2.17

155

(3008152) Bicarbonate [Moles/volume] in Arterial blood

202

0.88

0.15

4.6

6.0

23.74

24.15

mmol/l

0.17

195

(3025159) Blasts/Leukocytes in Blood

191

0.88

0.14

4.9

4.8

0.00

0.17

—

(3019977) pH of Arterial blood

366

0.92

0.14

4.8

7.5

7.43

7.41

0.97

217

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

170

1.13

0.14

2.9

2.0

1.86

1.76

0.20

130

(3017181) Myelocytes/Leukocytes in Blood

198

0.90

0.11

4.1

4.4

0.89

0.88

—

(3019150) Specific gravity of Urine by Refractometry

467

1.06

0.10

5.8

4.5

1.02

kg/l

0.99

321

(3009508) Creatinine [Moles/volume] in Urine

816

0.95

0.10

4.7

3.6

7.24

7.96

mmol/l

0.71

678

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.04

0.09

1.4

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.04

0.09

1.4

—

(3018418) pH of Serum or Plasma

662

0.96

0.09

5.4

5.0

7.39

0.17

483

(1616796) Gas panel - Central venous blood

1.07

0.08

7.2

4.3

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

1.04

0.08

1.7

1.6

—

(3024354) Oxygen [Partial pressure] in Venous blood

246

0.93

0.08

3.2

5.55

4.38

kpa

0.61

235

(3002582) Erythrocytes [#/volume] in Urine

818

1.04

0.08

5.1

3.7

66.08

179.31

e6/l

0.67

660

(3042936) Bacteria identified in Isolate by Culture

382

1.06

0.08

2.1

1.9

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.06

0.08

1.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.85

0.07

1.2

—

(3012544) pH of Venous blood

294

1.06

0.07

3.1

4.0

7.39

7.38

0.32

173

(3029937) Albumin [Presence] in Urine by Test strip

631

1.04

0.07

4.6

4.2

0.00

0.01

estimate

0.50

214

(40768797) Stomach Pathology biopsy report

257

1.06

0.05

1.4

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

333

0.96

0.05

1.5

1.2

2.08

1.31

u/ml

—

(3002179) Metamyelocytes/Leukocytes in Blood

189

1.06

0.05

4.1

4.4

1.27

0.42

0.59

(3019060) Gas panel - Arterial blood

201

0.94

0.04

3.3

3.9

—

(3003396) Base excess in Arterial blood by calculation

362

0.96

0.04

4.4

7.5

0.46

0.80

mmol/l

0.21

297

(3021440) Promyelocytes/Leukocytes in Blood

190

0.94

0.04

4.1

4.5

0.11

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

510

0.98

0.02

1.6

1.9

153846576.03

22717019.20

pmol/l

0.40

427

(3030467) Casts [#/volume] in Urine by Automated count

691

1.02

0.02

5.1

3.6

0.21

0.39

e6/l

1.17

541

(3007164) IgA [Mass/volume] in Serum or Plasma

316

0.98

0.00

1.8

1.4

2.40

3.02

g/l

1.04

189

(3021447) Carbon dioxide [Partial pressure] in Venous blood

291

1.00

0.00

3.0

4.0

5.43

5.74

kpa

1.11

278

(3018095) Leukocytes [#/volume] in Urine

871

1.00

0.00

5.9

4.2

78.53

177.11

e6/l

0.62

678

(3003694) ABO and Rh group [Type] in Blood

527

1.01

0.00

1.2

1.3

—

(3000492) Spirometry study

154

0.97

0.00

1.4

1.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

136

1.03

0.00

2.6

3.4

24.16

25.15

mmol/l

0.59

128

(3051101) Glucose [Moles/volume] in Cord blood

0.00

0.0

4.5

—

6.87

—

(3025443) Phadiatop IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.3

—

95.17

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

26.0

—

1257.83

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.2

—

60.20

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

19.5

—

834.83

—

(3039602) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Capillary blood

0.00

0.0

1.2

—

1.31

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.2

—

(3015479) Mycobacterium sp identified in Blood by Organism specific culture

0.00

0.0

1.5

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.3

—

254.00

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3023199) Leukocytes [#/volume] in Pleural fluid

1.02

-0.00

1.2

1.3

644.00

1999.42

e6/l

—

(40768443) Skin Pathology biopsy report

0.91

-0.00

1.1

1.3

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

1.00

-0.00

1.2

1.6

13.32

15.72

mg/l

—

(3028371) Actinomyces sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3022907) Direct antiglobulin test.polyspecific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

1.1

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

0.60

—

(3015956) Eosinophils/Leukocytes in Blood by Manual count

0.00

-0.00

0.0

2.2

—

2.20

—

(3001186) Copper [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

17.76

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.97

-0.00

2.0

1.8

38.00

47.88

nmol/l

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.89

-0.00

1.5

1.0

—

(4133840) Spirometry

0.00

-0.00

0.0

1.2

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.6

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.7

—

(3022689) Creatine [Moles/volume] in Urine

0.00

-0.00

0.0

1.6

—

9.99

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

-0.00

0.0

1.0

—

1.19

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

15.91

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.3

—

9.36

—

(3013166) Neutrophils/Leukocytes in Synovial fluid

0.00

-0.00

0.0

1.4

—

70.80

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

2.4

—

3.06

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.86

-0.00

1.2

1.6

18.80

31.89

g/l

—

(21494814) CD8 cells/Lymphocytes in Specimen

0.00

-0.00

0.0

1.6

—

34.86

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

4.2

—

153.00

—

(3013727) Leukocytes other/Leukocytes in Blood

0.00

-0.00

0.0

5.0

—

54.20

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

1042.50

—

(3014891) Appearance of Pleural fluid

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_PROSTATE and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_PROSTATE	1.364 [1.17, 1.6]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 550 out of 1196 males with CD2_BENIGN_PROSTATE died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_PROSTATE.

N-year risk	Females	Males
1	No data	0.208%
5	No data	1.545%
10	No data	3.859%
15	No data	7.262%
20	No data	12.475%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_PROSTATE – Benign neoplasm: Prostate

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Prostate

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints