Benign neoplasm: Other specified/unspecified intrathoracic organs (+ respiratory system NOS of Icd-9)

CD2_BENIGN_INTRATHORACIC_NOS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D15.7&, D15.9&
  • Hospital discharge: ICD-9 212[8-9]|2124
  • Hospital discharge: ICD-8 2124
  • Cause of death: ICD-10 D15.7&, D15.9&
  • Cause of death: ICD-9 212[8-9]|2124
  • Cause of death: ICD-8 2124

2 out of 7 registries used, show all original rules.

106

4. Check minimum number of events

None

106

5. Include endpoints

None

106

6. Filter based on genotype QC (FinnGen only)

92

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 643 324 311
Only index persons 503 282 221
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 53.15 54.00 51.91
Only index persons 50.65 52.73 48.01

-FinnGen-

Key figures

All Female Male
Number of individuals 92 44 48
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 53.56 53.46 53.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
94
Matched controls
940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D15.9
ICD-10 Finland
Benign neoplasm: Intrathoracic organ, unspecified
+∞
44.3
39
*
D15.7
ICD-10 Finland
Benign neoplasm: Other specified intrathoracic organs
+∞
43.1
38
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.1
14.4
32
73
GAE06
NOMESCO Finland
Excision of lesion of chest wall
+∞
9.5
9
*
D15.1
ICD-10 Finland
Benign neoplasm: Heart
+∞
7.4
7
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.8
7.2
18
44
21240
ICD-8 Finland
Benign neoplasm of respiratory system, Pleura
+∞
6.3
6
*
2129X
ICD-9 Finland
Benign neoplasm of respiratory and intrathoracic organs, Site unspecified
+∞
6.3
6
*
D15.2
ICD-10 Finland
Benign neoplasm: Mediastinum
+∞
6.3
6
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
6.2
27
99

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
94
2.92
4.29
3.7
3.4
3.88
6.94
e9/l
0.64
23
82
45
263
2.36
4.02
2.3
2.5
—
—
—
0
0
7
8
9.33
3.84
2.4
1.8
36.57
29.24
g/l
—
7
8
23
102
2.66
3.66
5.7
8.0
1.08
1.05
mmol/l
0.19
23
95
56
391
2.07
2.93
8.8
7.6
1.21
1.21
mmol/l
0.08
48
329
11
33
3.64
2.92
1.2
1.2
—
—
—
0
0
52
355
2.04
2.88
2.8
2.9
—
—
estimate
—
0
0
5
8
6.52
2.40
3.0
1.8
—
—
—
0
0
5
8
6.52
2.40
2.4
2.3
—
—
—
0
0
8
23
3.70
2.33
5.4
3.9
7.42
7.41
ph
—
8
23
53
390
1.82
2.12
19.2
14.0
1.22
1.26
inr
0.26
44
315
61
476
1.80
1.94
5.5
4.9
6.52
6.63
mmol/l
0.15
61
449
14
66
2.32
1.93
1.9
3.1
65.14
66.89
g/l
0.38
14
59
9
34
2.82
1.92
3.1
5.1
—
—
—
0
0
47
345
1.72
1.81
18.7
12.0
0.00
0.00
e9/l
0.55
42
286
28
178
1.82
1.76
5.2
5.0
—
—
—
0
0
5
13
4.00
1.74
2.2
1.8
26.00
32.00
pg
—
5
13
48
361
1.67
1.65
6.4
6.0
60.12
57.69
%
0.64
48
343
44
325
1.67
1.61
2.4
2.0
—
—
—
0
0
5
16
3.24
1.45
4.4
3.5
—
—
—
0
0
7
29
2.52
1.42
1.3
1.2
—
—
—
0
0
16
91
1.91
1.39
5.0
4.0
2.27
82.66
ug/l
0.56
16
76
20
123
1.80
1.38
1.9
1.7
—
—
—
0
0
44
337
1.57
1.33
5.2
4.3
21.53
50.83
ng/l
1.28
32
247
33
237
1.60
1.30
4.1
4.2
—
—
—
0
0
51
406
1.56
1.29
6.9
6.1
0.59
0.59
e9/l
0.00
46
354
51
408
1.55
1.25
6.8
6.1
0.03
0.04
e9/l
0.56
46
355
15
87
1.86
1.24
1.2
1.3
—
—
—
0
0
10
50
2.12
1.21
6.7
7.5
25.94
24.92
mmol/l
—
10
50
34
250
1.56
1.20
2.0
2.2
146.15
191.60
u/l
0.54
34
238
36
271
1.53
1.14
5.8
6.1
—
—
—
0
0
17
106
1.74
1.12
1.4
1.2
—
—
—
0
0
5
21
2.46
1.10
2.6
5.2
9.70
7.96
kpa
—
5
21
25
176
1.57
1.05
1.2
1.3
0.70
1.06
u/ml
—
10
47
9
48
1.97
1.04
1.2
1.4
—
—
—
0
0
18
121
1.60
0.91
2.3
1.8
—
—
—
0
0
20
139
1.56
0.89
2.1
1.6
1281.21
1265.21
nmol/l
0.03
15
105
13
81
1.70
0.86
1.5
1.5
—
—
—
0
0
34
266
1.44
0.86
2.9
2.4
55.62
57.51
u/l
0.16
29
246
17
115
1.58
0.84
5.2
5.3
105.41
104.10
mmol/l
0.69
17
115
33
260
1.41
0.80
5.2
4.1
0.00
0.02
estimate
0.49
12
85
10
59
1.78
0.79
9.1
5.1
1.22
1.22
mmol/l
—
10
50
5
28
1.83
0.67
2.8
4.1
24.56
23.90
mmol/l
—
5
28
74
791
0.70
0.65
23.2
15.3
—
—
—
0
0
8
51
1.62
0.62
2.1
1.2
328.29
440.72
u/ml
—
8
45
0
21
0.00
0.61
0.0
6.3
—
31.06
—
0
16
0
22
0.00
0.60
0.0
1.4
—
0.24
—
0
22
23
182
1.35
0.53
2.2
1.7
1.39
1.73
mg/l
0.22
18
145
9
65
1.42
0.52
6.9
3.7
—
—
—
0
0
30
250
1.29
0.49
3.4
3.5
33.62
63.65
mg/l
0.86
18
167
14
103
1.42
0.48
1.4
1.4
—
—
—
0
0
30
252
1.28
0.46
4.2
3.5
0.00
0.01
estimate
0.49
14
75
51
457
1.25
0.46
9.9
10.5
4.19
4.07
e9/l
0.17
46
395
25
205
1.30
0.46
1.5
1.4
—
—
—
0
0
8
55
1.50
0.44
5.3
2.8
153.13
144.62
ng/l
—
8
50
14
105
1.39
0.44
1.6
1.5
—
—
—
0
0
13
97
1.39
0.42
1.7
2.2
113.00
130.85
ug/g
—
8
80
29
246
1.26
0.41
7.0
4.1
7.39
7.40
ph
0.38
22
179
38
333
1.24
0.40
5.2
4.0
0.00
0.04
estimate
0.49
14
79
0
18
0.00
0.40
0.0
2.8
—
2.38
—
0
8
71
749
0.79
0.38
5.2
5.2
1.44
1.44
mmol/l
0.01
65
687
80
831
0.75
0.36
35.9
25.2
29.87
30.31
pg
1.39
80
825
80
831
0.75
0.36
36.1
25.2
6.71
6.78
e9/l
0.12
80
813
80
831
0.75
0.36
36.1
25.2
4.41
4.50
e12/l
1.01
80
812
48
436
1.21
0.35
5.2
4.2
0.00
0.00
estimate
-0.00
14
89
20
165
1.27
0.35
1.6
1.5
2.01
2.51
g/l
0.81
12
94
37
328
1.21
0.34
3.1
3.8
443.29
88.49
e6/l
0.59
28
232
6
45
1.36
0.34
9.0
3.4
25.62
24.15
mmol/l
—
6
45
80
830
0.76
0.34
36.0
25.2
90.25
91.07
fl
1.02
80
824
80
830
0.76
0.34
36.2
25.3
249.62
248.06
e9/l
0.08
80
816
6
46
1.32
0.33
1.3
1.6
—
—
—
0
0
29
252
1.22
0.33
8.5
6.5
—
—
—
0
0
7
54
1.32
0.31
1.1
1.6
—
—
—
0
0
47
431
1.18
0.29
5.3
4.1
0.00
0.00
estimate
-0.00
15
90
14
113
1.28
0.28
1.2
1.3
—
—
—
0
0
11
86
1.32
0.27
1.9
1.6
—
—
—
0
0
72
751
0.82
0.27
5.4
5.3
4.49
4.57
mmol/l
0.23
66
694
47
436
1.16
0.24
5.3
4.1
0.00
17.28
estimate
0.49
15
94
74
767
0.83
0.23
6.0
6.1
2.62
2.68
mmol/l
0.15
68
709
5
41
1.23
0.22
2.6
2.8
36.84
36.90
°c
—
5
41
28
251
1.16
0.22
4.3
3.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
60.13
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
50
1.21
0.20
6.0
8.4
0.60
0.67
%
—
6
50
6
51
1.19
0.20
6.0
7.8
1.05
1.39
%
—
6
51
70
725
0.86
0.19
6.9
6.8
38.47
39.80
mmol/mol
0.74
63
678
7
57
1.25
0.19
1.3
1.8
—
—
—
0
0
7
60
1.18
0.18
1.7
2.9
—
—
—
0
0
8
69
1.17
0.17
5.0
7.9
—
—
—
0
0
30
324
0.89
0.15
1.9
2.0
1.24
1.32
mmol/l
0.27
23
268
9
82
1.11
0.15
1.6
1.2
—
—
—
0
0
11
94
1.19
0.14
8.3
7.0
7.39
7.42
ph
—
6
62
28
259
1.12
0.13
5.1
4.1
3.40
8.99
mg/mmol
1.28
17
169
26
240
1.12
0.13
2.7
2.9
0.54
0.39
e6/l
0.17
20
174
15
133
1.15
0.13
4.7
3.0
16.55
21.06
%
1.29
15
123
72
739
0.89
0.13
5.4
5.4
5.84
6.03
mmol/l
0.72
66
681
37
349
1.10
0.12
2.0
2.1
89.23
95.39
pmol/l
0.35
16
167
80
784
1.14
0.11
26.6
19.5
139.66
139.72
mmol/l
0.07
80
774
80
815
0.88
0.11
29.0
21.6
83.82
79.22
umol/l
0.28
80
808
14
125
1.14
0.11
1.4
1.5
27.12
19.95
u/ml
—
6
46
80
786
1.12
0.09
26.8
19.7
3.98
3.99
mmol/l
0.24
80
775
5
60
0.82
0.08
1.4
1.2
—
—
—
0
0
5
64
0.77
0.08
1.0
1.4
—
—
—
0
0
29
281
1.05
0.03
3.3
3.5
—
—
—
0
0
30
291
1.05
0.03
2.8
3.1
13.12
56.92
e6/l
1.22
25
224
54
549
0.96
0.02
5.5
4.4
—
—
—
0
0
35
343
1.03
0.01
4.6
3.9
5.98
6.22
ph
0.62
21
188
15
144
1.05
0.00
1.3
1.4
115.20
32.65
iu/ml
—
5
51
17
168
1.01
0.00
3.1
2.8
2.47
2.46
mmol/l
0.36
17
147
52
522
0.99
0.00
5.6
4.5
—
44.91
—
0
11
29
286
1.02
0.00
5.6
3.9
—
—
—
0
0
76
760
1.00
-0.00
24.4
17.0
15.74
23.69
mg/l
3.30
69
633
0
5
0.00
-0.00
0.0
1.4
—
8.22
—
0
5
0
6
0.00
-0.00
0.0
2.8
—
13.85
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
28.60
—
0
5
0
9
0.00
-0.00
0.0
2.6
—
39.10
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
134.33
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
8.93
—
0
6
9
94
0.95
-0.00
1.8
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
204.86
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
55
0.90
-0.00
7.2
4.0
—
—
—
0
0
5
57
0.87
-0.00
6.2
3.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
3.76
—
0
5
8
84
0.95
-0.00
2.3
2.1
348.75
383.37
nmol/l
—
8
78
0
5
0.00
-0.00
0.0
1.8
—
1.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_INTRATHORACIC_NOS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_INTRATHORACIC_NOS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: CD2_BENIGN_INTRATHORACIC_NOS – Benign neoplasm: Other specified/unspecified intrathoracic organs (+ respiratory system NOS of Icd-9)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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