Benign neoplasm: Carotid body

CD2_BENIGN_CAROTIDBODY

hypopharynx cancer: A primary or metastatic malignant neoplasm that affects the hypopharynx.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D35.50&, D35.59& Hospital discharge: ICD-9 — 2275 Cause of death: ICD-10 — D35.50&, D35.59& Cause of death: ICD-9 — 2275 2 out of 7 registries used, show all original rules.	113
4. Check minimum number of events None	113
5. Include endpoints None	113
6. Filter based on genotype QC (FinnGen only)	103

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	CD2_BENIGN_CAROTIDBODY
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D355
HD_ICD_9	2275
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D355
COD_ICD_9	2275
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Carotid body based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	527	324	199
Only index persons	492	306	186
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	56.26	58.33	52.76
Only index persons	55.32	57.80	51.23

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	103	61	42
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	57.77	55.36	61.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
111: Matched controls
1110

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D35.59

ICD-10 Finland

Other paragangliom

+∞

93.3

D35.50

ICD-10 Finland

Carotid body

+∞

52.3

BDA10

NOMESCO Finland

Operation on carotid body

+∞

18.2

WX408

NOMESCO Finland

General anesthesy, balanced

4.8

15.1

183

DCB00

NOMESCO Finland

Excision of lesion of middle ear

+∞

11.7

Z31.5

ICD-10 Finland

Genetic counselling

8.3

9.9

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

4.8

9.7

H02AB09

ATC

hydrocortisone; systemic

13.1

9.4

EP1AE

NOMESCO Finland

Neck ultrasound examination

8.6

8.9

D14.0

ICD-10 Finland

Benign neoplasm: Middle ear, nasal cavity and accessory sinuses

54.4

8.8

EP1CG

NOMESCO Finland

Extensive MRI examination of soft tissue of neck with high intesity magnet

54.4

8.8

E23.00

ICD-10 Finland

Panhypopituitarism

97.1

8.5

102

Kela drug reimbursment

Diabetes insipidus

97.1

8.5

8680/3-C75.5

ICD-O-3

Paraganglioma, NOS, of aortic body and other paraganglia

+∞

8.4

E27.5

ICD-10 Finland

Adrenomedullary hyperfunction

+∞

8.4

D35.9

ICD-10 Finland

Benign neoplasm: Endocrine gland, unspecified

+∞

8.4

TPH07

NOMESCO Finland

Cathetrisation of artery

4.7

8.3

AA4CG

NOMESCO Finland

Extensive MRI examination of sella turcica with high intensity magnet

36.3

8.2

EP1DG

NOMESCO Finland

Very extensive examination of soft tissue of neck with high intesity magnet

48.5

7.8

JN5ER

NOMESCO Finland

PET-CT of receptors in whole body

85.6

7.5

D35.30

ICD-10 Finland

Craniopharyngoma

85.6

7.5

D35.6

ICD-10 Finland

Benign neoplasm: Aortic body and other paraganglia

+∞

7.4

D35.2

ICD-10 Finland

Benign neoplasm: Pituitary gland

21.8

7.3

101

Kela drug reimbursment

Anterior pituitary hypofunction

24.2

6.8

DC1AD

NOMESCO Finland

Temporalbone CT

24.2

6.8

9350/1-C75.2

ICD-O-3

Craniopharyngioma, NOS, of craniopharyngeal duct

73.9

6.5

YA1VG

NOMESCO Finland

MRI examination of head and neck with high intesity magnet for dose design of radiotherapy

73.9

6.5

UDC00

NOMESCO Finland

Ear microscopy

4.3

6.4

WX402

NOMESCO Finland

General anaesthesia

3.0

6.3

160

PA5DT

NOMESCO Finland

Embolisation of a tumor of carotis externa area

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

65.61

75.52

4.8

1.2

—

nmol/l

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

57.53

74.55

5.2

1.3

2.68

4.30

nmol/l

0.56

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

46.22

73.84

5.1

1.3

0.16

—

nmol/l

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

44.43

65.11

4.9

1.3

0.18

0.17

nmol/l

—

(4035726) Immunohistochemistry procedure

5.01

12.13

1.3

1.4

—

(3018418) pH of Serum or Plasma

312

2.80

6.63

4.3

4.2

7.40

7.39

1.24

219

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

505

2.96

6.39

6.9

8.5

1.21

1.22

mmol/l

0.46

451

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

463

2.79

6.13

3.0

3.1

—

estimate

—

(3035637) Corticotropin [Mass/volume] in Plasma

9.03

5.18

1.9

1.6

87.02

17.05

ng/l

—

(3044640) Blood type and Crossmatch panel - Blood

326

2.36

4.70

1.9

2.6

—

(40768804) Tissue Pathology biopsy report

388

2.27

4.32

2.4

2.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

10.56

4.07

2.9

1.9

58.57

269.57

nmol/l

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

5.12

3.65

1.1

1.2

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

8.20

3.61

2.4

1.2

10.00

14.33

ug/l

—

(3019977) pH of Arterial blood

109

2.53

3.57

5.5

13.4

7.40

7.42

0.66

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

240

2.12

3.39

1.9

2.7

—

(3002256) Pathology report gross observation

126

2.39

3.37

1.8

1.2

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

101

2.47

3.19

2.7

4.7

12.86

49.06

ug/l

0.38

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.49

3.14

5.0

3.5

—

(3026389) Candida sp identified in Specimen by Organism specific culture

7.84

3.09

1.5

1.1

—

(3023368) Bacteria identified in Blood by Culture

257

2.02

3.04

5.0

4.8

—

(3019060) Gas panel - Arterial blood

2.94

3.02

3.5

13.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

162

2.17

3.01

2.4

1.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

103

900

3.00

2.96

5.3

5.6

1.80

1.82

mu/l

0.06

832

(42870588) Differential panel, method unspecified - Blood

343

1.90

2.75

5.3

5.8

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.37

2.73

2.5

2.4

—

(3000991) Gas panel - Venous blood

2.40

2.70

4.9

11.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.54

2.63

5.2

9.8

25.23

25.20

mmol/l

0.01

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

5.69

2.58

1.3

—

(40768797) Stomach Pathology biopsy report

129

2.10

2.41

1.4

1.3

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

5.75

2.23

1.0

1.3

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

246

1.83

2.23

2.5

2.87

2.81

mg/l

0.05

210

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.07

2.12

1.1

1.5

—

(3033658) Prothrombin time (PT) actual/Normal

254

1.75

1.98

3.8

4.6

92.45

93.37

0.08

249

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

455

1.69

1.98

3.1

2.9

73.20

77.66

nmol/l

0.57

407

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.00

1.90

1.1

1.5

—

(40761536) Microorganisms panel - Urine sediment

2.19

1.85

2.9

4.2

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.28

1.80

6.6

12.8

94.58

94.80

0.06

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

192

1.77

1.79

3.6

3.4

706.42

280.51

ng/l

0.30

138

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.21

1.79

2.4

5.1

24.31

24.45

mmol/l

0.05

(3032080) INR in Blood by Coagulation assay

438

1.62

1.71

9.7

12.5

1.14

1.18

inr

0.38

367

(3003694) ABO and Rh group [Type] in Blood

283

1.65

1.7

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

123

1.87

1.65

2.2

1.6

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

321

1.61

1.60

2.6

2.8

51.18

67.86

u/l

0.65

304

(44790048) Parainfluenza type 2 nucleic acid detection

3.44

1.54

1.0

1.5

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.44

1.54

1.2

—

(44790049) Parainfluenza type 3 nucleic acid detection

3.44

1.54

1.0

1.5

—

(44790047) Parainfluenza type 1 nucleic acid detection

3.44

1.54

1.0

1.5

—

(44806118) Parainfluenza type 4 nucleic acid detection

3.44

1.54

1.0

1.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

3.44

1.54

1.2

1.3

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

546

1.57

1.50

7.0

7.6

20.22

10.51

umol/l

0.75

520

(3029937) Albumin [Presence] in Urine by Test strip

290

1.59

1.48

4.0

4.1

0.00

estimate

-0.00

(3013115) Eosinophils [#/volume] in Blood

547

1.57

1.48

6.1

6.7

0.18

0.19

e9/l

0.37

478

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

120

1.81

1.46

2.4

1.6

—

(3021589) Normoblasts [#/volume] in Blood

460

1.55

1.44

13.7

11.6

0.00

0.01

e9/l

0.50

364

(3019198) Lymphocytes [#/volume] in Blood

541

1.54

1.40

6.1

6.6

1.68

1.88

e9/l

0.98

480

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

101

921

2.07

1.39

21.4

15.4

83.42

82.92

ml/min/173m2

0.08

851

(3024928) Oxygen saturation in Venous blood

2.70

1.38

1.2

3.7

71.55

58.71

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.46

1.32

1.1

1.6

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.58

1.32

1.2

1.5

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.48

1.26

1.2

1.4

—

(3022145) Colonoscopy Study observation

118

1.74

1.25

1.3

1.4

—

(3001604) Monocytes [#/volume] in Blood

530

1.49

1.23

5.9

6.5

0.56

0.55

e9/l

0.16

455

(3006315) Basophils [#/volume] in Blood

530

1.49

1.23

5.9

6.5

0.04

e9/l

0.11

453

(3044290) Cell count panel - Cerebral spinal fluid

2.57

1.16

1.4

1.5

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

595

1.48

1.15

8.7

10.9

4.15

4.07

e9/l

0.09

517

(46235355) HIV 1 and 2 tests - Meaningful Use set

191

1.55

1.08

1.6

2.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.19

1.07

2.0

2.1

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.86

1.05

2.1

4.52

5.50

ug/l

0.31

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.33

1.04

1.0

1.4

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.33

1.04

1.0

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

103

966

1.92

1.02

20.0

16.3

26.14

22.18

mg/l

0.51

789

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.07

1.02

2.1

2.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.98

0.0

1.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.95

0.96

1.6

1.2

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.95

0.96

2.6

3.5

8.71

1011.25

u/ml

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.88

0.88

1.3

1.2

—

(3037522) Nuclear Ab [Titer] in Serum

148

1.52

0.86

1.4

1.5

320.00

680.00

titre

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

202

1.44

0.83

3.3

4.5

17.75

22.11

0.91

(3041096) Erythrocytes [Presence] in Urine by Automated

303

1.39

0.83

3.2

3.3

0.14

0.00

estimate

0.47

(3013512) EKG study

333

1.37

0.79

3.0

3.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.67

0.78

1.4

1.6

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.78

0.0

5.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

411

1.34

0.77

4.3

3.9

0.00

estimate

-0.00

(40761511) CBC panel - Blood by Automated count

105

1001

1.90

0.77

18.5

14.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

109

1.55

0.76

2.1

1.7

—

(3019230) Fractional oxyhemoglobin in Venous blood

2.13

0.75

1.2

2.6

71.60

58.43

—

(3012544) pH of Venous blood

112

1.50

0.68

2.4

4.7

7.38

7.39

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.54

0.68

1.2

1.8

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

192

1.39

0.67

1.9

1.6

431.49

480.22

pmol/l

0.36

166

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

152

0.62

0.67

1.4

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.54

0.64

1.3

1.4

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

1.70

0.62

4.2

2.1

27.32

24.26

mmol/l

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.70

0.62

1.0

1.2

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.60

0.0

1.7

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.60

0.0

3.0

—

18.83

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

917

1.46

0.60

6.8

6.1

38.46

39.22

mmol/mol

0.42

865

(3015736) pH of Urine

435

1.27

0.57

3.6

3.5

6.13

6.24

0.32

242

(3026008) Bacteria identified in Urine by Culture

310

1.29

0.56

3.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

282

1.30

0.56

1.6

1.8

23.43

22.20

nmol/l

0.15

237

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

647

1.27

0.54

3.1

—

(3020891) Body temperature

1.57

0.54

7.7

4.8

36.92

36.93

°c

—

(40758558) Short blood count panel - Blood

312

1.28

0.53

6.3

7.1

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.53

0.52

1.8

1.6

1.14

1.15

g/l

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

1.53

0.52

1.8

1.6

0.20

0.23

g/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

137

1.37

0.51

7.2

7.7

102.67

104.47

mmol/l

0.71

137

(3001122) Ferritin [Mass/volume] in Serum or Plasma

461

1.24

0.49

3.7

3.1

165.36

108.07

ug/l

0.38

426

(3009261) Glucose [Presence] in Urine by Test strip

551

1.24

0.48

4.4

4.0

0.00

estimate

-0.00

100

(3023520) Reticulocytes [#/volume] in Blood

1.42

0.46

2.1

3.1

77.47

73.76

e9/l

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.47

0.43

1.1

1.2

—

30.92

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.43

0.43

2.5

3.0

0.36

0.63

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.43

0.43

2.5

3.1

1.30

1.18

—

(3028626) Oxygen [Partial pressure] in Capillary blood

1.54

0.42

5.2

3.5

9.64

9.05

kpa

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.41

0.0

3.7

—

1.20

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.41

0.0

3.7

—

3.99

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.41

0.0

3.7

—

106.73

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.41

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.2

—

4.88

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.49

0.41

2.0

—

(3042936) Bacteria identified in Isolate by Culture

152

1.30

0.40

1.6

2.4

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

538

1.21

0.40

4.5

3.9

0.00

estimate

-0.00

103

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

1.45

0.36

2.2

1.8

0.43

1.63

ug/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.42

0.35

1.3

2.0

—

(3035350) Ketones [Presence] in Urine by Test strip

544

1.18

0.33

4.4

3.9

0.00

estimate

-0.00

107

(4024509) Urine culture

1.32

0.33

1.8

1.7

—

(21494755) Public health laboratory ask at order entry panel

0.70

0.32

1.4

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.37

0.31

3.1

2.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

167

1.24

0.31

1.5

1.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

432

0.85

0.30

1.8

2.0

1.54

1.36

mmol/l

0.72

362

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

109

0.71

0.30

10.6

5.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.29

0.28

1.0

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

238

1.18

0.25

3.5

5.8

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

153

1.21

0.24

2.0

3.1

0.79

0.72

ug/l

—

(3049717) Cytology report of Urine Cyto stain

1.37

0.24

3.4

2.9

—

(3019309) Folate [Moles/volume] in Red Blood Cells

144

1.21

0.23

1.6

880.44

1145.24

nmol/l

—

110

(4195642) Thrombophilia screening test

0.00

0.21

0.0

1.3

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.5

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.3

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.5

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

0.21

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

1.1

—

90.27

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

1.4

—

(3000492) Spirometry study

108

1.23

0.21

1.6

1.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

165

0.83

0.21

2.7

3.2

5.60

3.04

e6/l

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.1

—

(4268621) Lupus anticoagulant assay

0.00

0.21

0.0

1.9

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

1.3

—

1.20

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.20

0.0

1.1

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

0.20

0.0

1.6

—

9.50

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.20

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.20

0.0

1.9

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

137

1.20

0.20

1.3

1.5

—

(36660697) Celiac disease serology panel - Serum

110

1.21

0.18

1.3

1.2

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

151

1.15

0.14

1.9

2.3

30.00

28.71

0.41

146

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

222

1.10

0.11

1.4

1.3

12.72

24.92

iu/ml

1.10

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

207

0.90

0.10

1.5

1.7

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

227

0.91

0.10

1.7

1.9

0.75

1.25

mg/l

0.65

182

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.04

0.09

1.4

1.3

—

(3022313) Gas panel - Capillary blood

1.12

0.09

3.3

4.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

117

1.13

0.08

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

433

1.07

0.08

1.9

2.1

87.48

98.18

pmol/l

0.81

209

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

384

1.07

0.07

4.3

3.6

15.87

30.15

ng/l

1.68

265

(3019225) pH of Specimen

1.04

0.07

3.8

4.7

7.39

7.38

—

(3017181) Myelocytes/Leukocytes in Blood

0.86

0.07

3.5

5.2

—

1.10

—

(3014051) Protein [Presence] in Urine by Test strip

304

0.94

0.06

3.7

3.1

—

0.40

—

(3019150) Specific gravity of Urine by Refractometry

238

1.07

0.05

5.6

3.9

1.02

kg/l

0.11

155

(3018095) Leukocytes [#/volume] in Urine

387

1.05

0.05

4.0

4.2

28.68

48.58

e6/l

0.52

261

(3009508) Creatinine [Moles/volume] in Urine

329

1.05

0.04

2.7

3.3

6.76

8.12

mmol/l

0.65

282

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

200

0.94

0.04

1.5

1.3

4.77

7.31

u/ml

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

179

0.94

0.03

3.2

3.0

0.21

0.83

e6/l

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.10

0.03

1.8

1.4

—

(3012516) Albumin [Mass/volume] in Urine

302

1.04

0.02

2.7

3.4

32.36

57.17

mg/l

0.52

199

(36304419) Bacteria [Presence] in Urine

284

1.03

0.00

3.2

3.1

—

estimate

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

118

1.02

0.00

1.8

2.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

312

0.99

0.00

3.4

3.9

10.39

9.69

mg/mmol

0.04

198

(1761868) Lipid panel - Serum or Plasma

399

1.00

0.00

3.4

3.2

—

(3030467) Casts [#/volume] in Urine by Automated count

301

1.00

0.00

3.4

3.2

0.07

0.37

e6/l

3.08

213

(3002582) Erythrocytes [#/volume] in Urine

346

1.02

0.00

3.3

108.25

215.20

e6/l

0.22

258

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

125

0.96

0.00

1.8

2.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

919

1.01

0.00

5.7

4.9

5.86

5.90

mmol/l

0.17

845

(3007164) IgA [Mass/volume] in Serum or Plasma

249

1.01

0.00

1.5

1.4

3.91

2.34

g/l

0.90

137

(3000494) Fungus identified in Specimen by Culture

129

1.01

0.00

1.7

1.6

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.6

—

6.96

—

(3036185) Alkaline phosphatase.liver 2 [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

13.81

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

12.3

—

0.60

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

100.44

—

(3025159) Blasts/Leukocytes in Blood

0.91

-0.00

3.6

6.0

—

0.38

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

-0.00

0.0

1.2

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3022689) Creatine [Moles/volume] in Urine

0.00

-0.00

0.0

1.0

—

12.26

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

11.0

—

102.00

—

(3002179) Metamyelocytes/Leukocytes in Blood

0.94

-0.00

3.5

5.3

—

0.74

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

3.7

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(1002224) Polysomnography panel

0.97

-0.00

1.0

1.1

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

0.33

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.0

—

151.80

—

(3021440) Promyelocytes/Leukocytes in Blood

0.92

-0.00

3.5

5.5

—

0.25

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.2

—

10.02

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

8.27

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

2.0

—

8.16

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

5.0

—

248.18

—

(3035062) Alkaline phosphatase.liver 1 [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

61.59

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.93

-0.00

1.8

2.1

—

(3034426) Prothrombin time (PT)

0.00

-0.00

0.0

1.0

—

27.80

—

(3020650) Glucose [Presence] in Urine

0.00

-0.00

0.0

1.3

—

0.00

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.4

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.0

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

1361.50

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

20.3

—

947.44

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.2

—

35.72

—

(3009343) pH of Capillary blood

0.94

-0.00

5.3

3.8

7.43

7.42

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.3

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.2

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.1

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.92

-0.00

1.0

1.4

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.7

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

2.1

—

1.13

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.98

-0.00

1.5

2.0

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

3.2

—

96.20

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.2

—

4.61

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.3

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

23.7

—

1824.78

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(21494815) CD4 cells/Lymphocytes in Specimen

0.00

-0.00

0.0

2.1

—

39.19

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_CAROTIDBODY and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CAROTIDBODY.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_CAROTIDBODY – Benign neoplasm: Carotid body

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Carotid body

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints