Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system, including Hilmo

C3_SPINAL_CORD_CRANIAL_AND_OTHER_CNS_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C72
  • Hospital discharge: ICD-9 192
  • Hospital discharge: ICD-8 192
  • Cause of death: ICD-10 C72
  • Cause of death: ICD-9 192
  • Cause of death: ICD-8 192
  • Cause of death: excluded ICD-9 1921|1923|1928
  • Cancer registry: Topography ICD-O-3 C72
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

321

4. Check minimum number of events

None

321

5. Include endpoints

None

321

6. Filter based on genotype QC (FinnGen only)

287

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system, including Hilmo based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 287 150 137
Unadjusted period prevalence (%) 0.06 0.05 0.06
Median age at first event (years) 53.45 48.72 58.62

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
300
Matched controls
3000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB02
ATC
dexamethasone; systemic
86.4
152.7
82
13
130
Kela drug reimbursment
Malignant tumour
+∞
66.1
61
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
9.4
54.8
76
105
C72.00
ICD-10 Finland
Malignant tumor of the spinal cord without histology
+∞
52.7
49
*
C72.1
ICD-10 Finland
Malignant neoplasm: Cauda equina
+∞
47.1
44
*
ABB10
NOMESCO Finland
Resection of lesion of spinal canal
496.0
44.4
43
*
C72.9
ICD-10 Finland
Malignant neoplasm: Central nervous system, unspecified
+∞
42.7
40
*
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
+∞
41.6
39
*
A03FA01
ATC
metoclopramide; systemic, rectal
5.6
37.0
88
208
XX3DW
NOMESCO Finland
Time consuming IT work
11.1
36.5
41
42
A04AA01
ATC
ondansetron; systemic, rectal
14.1
35.5
34
27
C72.09
ICD-10 Finland
Malignant tumor of the spinal cord other histology
+∞
34.0
32
*
9391/3-C72.0
ICD-O-3
Ependymoma, NOS, of spinal cord
+∞
32.9
31
*
WF002
NOMESCO Finland
Radical radiotherapy
89.3
29.4
32
*
JN4AD
NOMESCO Finland
Body CT examination
7.4
28.6
45
70
A04AA02
ATC
granisetron; systemic, transdermal
308.8
28.2
28
*
JN4BD
NOMESCO Finland
Extensive body CT
7.9
26.5
39
56
C72.2
ICD-10 Finland
Malignant neoplasm: Olfactory nerve
+∞
26.4
25
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
147.8
26.1
27
*
C72.01
ICD-10 Finland
Malignant tumor of the spinal cord grade II glioma
+∞
25.4
24
*
Z51.5
ICD-10 Finland
Palliative care
8.5
24.3
33
43
C72.3
ICD-10 Finland
Malignant neoplasm: Optic nerve
+∞
23.2
22
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
43.9
23.1
28
7
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
22.2
21
*
D43.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Spinal cord
+∞
21.1
20
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
225.0
20.8
21
*
L01AX03
ATC
temozolomide; systemic
+∞
20.0
19
*
D33.4
ICD-10 Finland
Benign neoplasm: Spinal cord
+∞
19.0
18
*
N02AA05
ATC
oxycodone; systemic
3.7
18.6
69
222
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
8.0
18.5
26
35
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
18.2
97
391
XKC03
NOMESCO Finland
Water cystometry
8.2
18.1
25
33
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
17.9
17
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
31.0
17.7
23
8
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.5
17.4
72
248
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
+∞
16.8
16
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
179.6
16.7
17
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.2
16.6
36
76
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
13.9
16.5
28
22
XKD06
NOMESCO Finland
Physiologic investigation of micturition
6.9
15.6
25
39
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
6.2
15.2
27
47
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
14.7
14
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
14.7
14
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
14.7
14
*
115
Kela drug reimbursment
Breast cancer
+∞
14.7
14
*
C72.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of brain and other parts of central nervous system
+∞
14.7
14
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
14.4
14.5
24
18
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
20.4
14.4
21
11
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
18.7
14.0
21
12
D33.40
ICD-10 Finland
Benign glioma of the spinal cord (grade I)
+∞
13.6
13
*
9522/3-C30.0
ICD-O-3
Olfactory neuroblastoma of nasal cavity
+∞
13.6
13
*
D33.41
ICD-10 Finland
Myxopapillary epndymoma of the spinal cord (grade I)
+∞
13.6
13
*
N18
ICPC
Paralysis/weakness
10.4
13.0
25
26
M03BX01
ATC
baclofen; systemic
11.8
12.8
23
21
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
12.6
12
*
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
+∞
12.6
12
*
1922A
ICD-9 Finland
Malignant neoplasm of other and unspecified parts of nervous system, Spinal cord
+∞
12.6
12
*
D33.43
ICD-10 Finland
Spinal cord
+∞
12.6
12
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
12.6
12
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
135.4
12.5
13
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.2
11.9
33
85
UKC02
NOMESCO Finland
Cystoscopy
3.1
11.8
56
207
G82.2
ICD-10 Finland
Paraplegia, unspecified
31.4
11.8
15
5
WZC00
NOMESCO Finland
Treatment plan or consultation
2.5
11.6
104
532
Z2446
NOMESCO Finland
Social worker
4.1
11.5
33
87
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
8.9
11.5
24
29
C72.0
ICD-10 Finland
Malignant neoplasm: Spinal cord
+∞
11.5
11
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
11.5
11
*
R4120
NOMESCO Finland
Occupational therapy
4.3
11.0
30
76
N03AX16
ATC
[U] pregabalin
2.6
10.8
80
373
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
62.3
10.7
12
*
R4110
NOMESCO Finland
Physiotherapy
2.4
10.6
91
455
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
+∞
10.5
10
*
L03AA02
ATC
filgrastim; parenteral
+∞
10.5
10
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
+∞
10.5
10
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
10.5
10
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
10.5
10
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
11.9
10.2
18
16
R1250
NOMESCO Finland
Evaluation of functional capability
9.7
10.2
20
22
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
27.1
9.9
13
5
ZXE20
NOMESCO Finland
More than three and less than five hours
3.0
9.9
49
185
L28
ICPC
Limited function/disability (L)
2.5
9.8
77
367
N03AE01
ATC
clonazepam; systemic
3.8
9.8
31
88
L03AA13
ATC
pegfilgrastim; parenteral
56.9
9.7
11
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
11.9
9.7
17
15
H02AB09
ATC
hydrocortisone; systemic
10.6
9.7
18
18
D32.1
ICD-10 Finland
Benign neoplasm: Spinal meninges
103.2
9.5
10
*
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
103.2
9.5
10
*
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
22.6
9.4
13
6
C30.0
ICD-10 Finland
Malignant neoplasm: Nasal cavity
+∞
9.4
9
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
9.4
9
*
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
+∞
9.4
9
*
2312
FHL
Extirpation or destruction
+∞
9.4
9
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
9.4
9
*
Q85.01
ICD-10 Finland
Neurofibromatosis, type 2
+∞
9.4
9
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
9.4
9
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
4.4
9.4
24
58
L72.1
ICD-10 Finland
Trichilemmal cyst
3.9
9.4
29
81
ZX120
NOMESCO Finland
Intravenous
4.0
9.3
27
72
J01MA12
ATC
levofloxacin; systemic
2.6
9.3
64
287
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
9.2
112
642
ZXE30
NOMESCO Finland
More than five and less than seven hours
7.2
9.0
21
31
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
24.9
9.0
12
5
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
24.9
9.0
12
5
H53.4
ICD-10 Finland
Visual field defects
9.0
8.9
18
21
Z3231
NOMESCO Finland
Registered nurse
2.3
8.8
88
465
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
51.5
8.7
10
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
8.6
8.7
18
22
TPH07
NOMESCO Finland
Cathetrisation of artery
3.1
8.7
38
133
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
12.1
8.7
15
13
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
92.6
8.5
9
*
N03AX14
ATC
levetiracetam; systemic
7.4
8.4
19
27
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
8.4
8
*
2311
FHL
Resection
+∞
8.4
8
*
116
Kela drug reimbursment
Prostate cancer
+∞
8.4
8
*
1929X
ICD-9 Finland
Malignant neoplasm of other and unspecified parts of nervous system, Nervous system, part unspecified
+∞
8.4
8
*
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
8.4
8
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
8.4
8
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
8.4
8
*
C71.20
ICD-10 Finland
Malignant tumor in temporal lobe without histology
+∞
8.4
8
*
C50.99
ICD-10 Finland
Breast, unspecified
+∞
8.4
8
*
C72.4
ICD-10 Finland
Malignant neoplasm: Acoustic nerve
+∞
8.4
8
*
TKC20
NOMESCO Finland
Catheterisation of bladder
3.4
8.3
31
98
B01AB05
ATC
enoxaparin; parenteral
2.2
8.3
93
513
WX704
NOMESCO Finland
Intubation
3.5
8.3
29
88
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.8
8.3
45
178
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
8.2
38
138
ZX090
NOMESCO Finland
Other technic of radiotherapy
34.4
8.1
10
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
10.5
8.1
15
15
ZXC95
NOMESCO Finland
Use of surgical navigator
13.5
8.0
13
10
H47.2
ICD-10 Finland
Optic atrophy
46.2
7.8
9
*
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
46.2
7.8
9
*
WW500
NOMESCO Finland
Blood transfusion
9.2
7.6
15
17
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
7.6
68
341
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.1
7.5
33
116
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.2
7.5
20
50
D33.30
ICD-10 Finland
Acoustic neuroma
13.8
7.4
12
9
ZXD05
NOMESCO Finland
Urgent procedure
2.1
7.4
97
566
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
7.4
58
275
G82.1
ICD-10 Finland
Spastic paraplegia
+∞
7.3
7
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
7.3
7
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
7.3
7
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
7.3
7
*
A79
ICPC
Malignancy NOS
+∞
7.3
7
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
7.3
7
*
1920A
ICD-9 Finland
Malignant neoplasm of other and unspecified parts of nervous system, Cranial nerves
+∞
7.3
7
*
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
+∞
7.3
7
*
19251
ICD-8 Finland
Malignant neoplasm of other part of nervous system, Sympathetic nervous system
+∞
7.3
7
*
N76
ICPC
Neoplasm nervous system unspecified
+∞
7.3
7
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
+∞
7.3
7
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
7.3
113
698
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
30.8
7.2
9
*
L02AE02
ATC
leuprorelin; implant, parenteral
20.6
7.2
10
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
7.1
63
315
A02BC02
ATC
pantoprazole; systemic
2.0
7.0
199
1499
R33
ICD-10 Finland
Retention of urine
2.9
6.9
34
127
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.5
6.8
24
73
XCK00
NOMESCO Finland
Perimetry
3.2
6.8
27
89
E23.00
ICD-10 Finland
Panhypopituitarism
41.0
6.8
8
*
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
41.0
6.8
8
*
HAB40
NOMESCO Finland
Wedge excision of mammary gland
41.0
6.8
8
*
SPAT1229
SPAT
Assessment of need for aid
3.0
6.6
29
102
R4190
NOMESCO Finland
Nutritional therapy
6.4
6.6
16
26
XKD00
NOMESCO Finland
Uroflowmetry
2.5
6.5
43
188
2252A
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Cerebral meninges
71.3
6.4
7
*
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
14.7
6.4
10
7
D14.0
ICD-10 Finland
Benign neoplasm: Middle ear, nasal cavity and accessory sinuses
14.7
6.4
10
7
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.0
6.4
18
47
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
6.3
6
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
6.3
6
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
6.3
6
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
6.3
6
*
C71.10
ICD-10 Finland
Malignant tumor in frontal lobe without histology
+∞
6.3
6
*
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
+∞
6.3
6
*
DNB30
NOMESCO Finland
Excision of lesion of ethmoidal sinus
+∞
6.3
6
*
1921A
ICD-9 Finland
Malignant neoplasm of other and unspecified parts of nervous system, Cerebral meninges
+∞
6.3
6
*
9380/3-C71.9
ICD-O-3
Glioma, malignant of brain, NOS
+∞
6.3
6
*
WD205
NOMESCO Finland
Therapy of methastized malignancy with hormones
+∞
6.3
6
*
2377A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Neurofibromatosis
+∞
6.3
6
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
6.3
6
*
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
27.3
6.3
8
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.9
6.2
30
111
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
6.2
38
160
AA1AD
NOMESCO Finland
CT of head and brain
1.9
6.1
93
566
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
5.8
6.1
16
29

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
63
54
14.50
63.96
1.5
1.5
—
—
—
0
0
72
262
3.30
15.83
7.1
9.1
7.42
7.42
ph
0.22
48
136
70
256
3.26
15.22
7.2
9.2
1.27
1.11
mmol/l
0.14
60
216
26
51
5.49
12.93
2.3
1.1
—
—
—
0
0
26
55
5.08
11.90
2.3
1.2
1628.16
293.75
e6/l
0.42
19
44
21
19
11.79
11.73
2.4
1.1
—
—
—
0
0
178
1158
2.32
11.33
9.2
6.2
1.19
1.21
mmol/l
2.82
158
1012
25
54
4.96
11.16
2.2
1.1
10.00
18.71
e6/l
0.28
17
42
123
693
2.31
10.93
2.6
2.0
—
—
—
0
0
105
556
2.37
10.74
4.3
3.6
93.42
89.96
%
0.69
95
547
160
1015
2.24
10.57
8.0
6.0
1.20
1.21
mmol/l
1.97
154
929
127
739
2.25
10.31
2.7
1.7
—
—
—
0
0
104
576
2.23
9.36
5.3
3.8
—
—
—
0
0
152
1009
2.03
8.25
3.0
2.4
—
—
estimate
—
0
0
63
301
2.38
7.88
9.0
6.4
104.54
104.34
mmol/l
0.11
63
301
48
202
2.64
7.84
10.0
8.4
—
—
—
0
0
17
23
7.77
7.79
1.8
1.1
—
—
—
0
0
118
761
1.91
6.58
5.0
2.0
2.33
2.36
mmol/l
1.69
112
667
107
671
1.92
6.48
5.2
3.0
—
—
—
0
0
189
1433
1.86
6.18
7.1
4.5
6.63
6.65
mmol/l
0.04
181
1353
14
24
6.06
5.60
1.4
1.3
21.19
24.32
ng/l
0.34
14
24
112
742
1.81
5.55
8.8
5.2
—
—
—
0
0
27
101
2.84
5.50
3.5
1.7
3.82
2.57
ug/l
1.06
20
75
168
1271
1.73
5.13
15.5
6.3
3.81
4.22
e9/l
1.95
147
1088
96
632
1.76
4.73
4.1
2.8
0.55
0.43
e6/l
0.28
74
444
48
258
2.02
4.40
5.8
3.5
7.38
7.39
ph
0.26
34
151
71
1060
0.57
4.19
1.9
1.9
1.29
1.35
mmol/l
0.43
65
904
7
7
10.20
4.03
1.0
1.1
—
—
—
0
0
28
126
2.35
3.97
3.9
8.5
—
—
—
0
0
105
738
1.65
3.96
4.1
2.9
53.47
133.57
e6/l
0.41
81
547
142
1076
1.61
3.95
16.0
14.5
1.23
1.27
inr
0.42
120
892
97
669
1.66
3.93
4.8
2.8
7.40
7.40
ph
0.11
68
454
68
425
1.78
3.93
4.5
2.6
541.02
535.70
mosm/kgh2o
0.07
62
367
205
2343
0.61
3.79
5.0
5.1
5.82
5.96
mmol/l
1.21
188
2162
153
1193
1.58
3.69
8.5
5.3
0.55
0.57
e9/l
0.46
131
1002
140
1072
1.57
3.64
8.6
5.5
9.06
8.69
%
0.74
132
1004
87
598
1.64
3.53
4.1
2.7
—
0.00
estimate
—
0
7
153
1202
1.56
3.51
8.5
5.3
0.04
0.04
e9/l
0.34
130
1015
141
1088
1.56
3.50
8.4
5.4
59.08
57.32
%
1.06
135
1036
142
1099
1.55
3.47
8.6
5.4
25.60
27.76
%
1.38
135
1037
139
1074
1.55
3.41
8.6
5.5
0.69
0.69
%
0.06
131
999
154
1218
1.54
3.39
8.6
5.4
1.61
1.85
e9/l
3.10
136
1056
138
1069
1.54
3.32
8.6
5.4
2.54
2.93
%
1.66
129
998
16
60
2.76
3.28
3.1
1.3
1.24
1.41
ratio
—
10
35
6
7
8.71
3.27
1.3
1.0
—
—
—
0
0
32
166
2.04
3.24
1.8
2.7
0.21
0.21
g/l
0.16
27
148
155
1238
1.52
3.20
9.0
5.4
0.15
0.19
e9/l
4.40
135
1066
46
274
1.80
3.10
2.1
1.7
—
—
—
0
0
181
1502
1.52
3.06
7.3
4.2
—
2541.71
—
0
21
9
22
4.18
2.90
1.2
1.1
—
—
—
0
0
212
2366
0.65
2.87
4.5
5.1
1.39
1.47
mmol/l
2.46
190
2211
56
362
1.67
2.84
4.0
2.8
1.99
2.98
e6/l
0.47
31
157
214
2382
0.65
2.83
4.6
5.2
4.49
4.63
mmol/l
1.38
192
2237
218
2416
0.64
2.80
5.1
5.9
2.65
2.71
mmol/l
0.50
202
2262
7
14
5.09
2.74
1.6
1.4
—
—
—
0
0
24
122
2.05
2.59
4.8
2.5
25.80
25.45
mmol/l
0.24
24
116
31
173
1.88
2.58
1.3
1.4
—
—
—
0
0
201
2253
0.67
2.56
4.0
4.4
1.27
1.27
mmol/l
0.05
180
2084
71
499
1.55
2.56
3.2
2.3
9.64
8.32
e6/l
0.13
63
447
130
1035
1.45
2.55
15.5
8.9
0.01
0.00
e9/l
0.58
107
825
203
1759
1.48
2.54
12.0
5.6
81.78
76.25
u/l
1.24
198
1651
111
860
1.46
2.50
5.0
3.6
83.43
101.55
e6/l
0.20
84
576
56
374
1.61
2.50
2.2
2.2
12.01
13.58
umol/l
0.77
51
347
6
12
5.08
2.41
3.7
1.9
0.53
0.79
e9/l
—
6
12
42
267
1.67
2.27
1.4
1.5
—
—
—
0
0
29
166
1.83
2.25
3.9
4.4
1.64
0.63
%
0.83
11
34
47
309
1.62
2.24
2.3
2.0
—
—
—
0
0
33
197
1.76
2.23
3.8
4.2
7.39
7.33
ph
1.40
27
140
8
25
3.26
2.11
2.3
1.2
224.50
301.70
mu/l
—
8
20
208
2282
0.71
1.92
5.7
6.5
38.12
39.37
mmol/mol
1.46
194
2155
27
161
1.74
1.85
4.0
4.5
0.44
0.07
%
—
9
29
48
332
1.53
1.85
1.6
1.6
—
—
—
0
0
88
688
1.39
1.81
11.0
4.2
—
—
—
0
0
6
18
3.38
1.75
1.5
1.2
—
—
—
0
0
26
157
1.72
1.72
4.2
4.4
1.33
0.19
%
—
9
32
5
13
3.89
1.72
2.0
1.2
—
—
—
0
0
92
732
1.37
1.69
2.3
2.3
64.48
61.87
u/l
0.08
83
684
13
62
2.15
1.68
4.9
1.7
—
—
—
0
0
5
14
3.61
1.62
1.2
1.0
1633.60
1295.93
miu/ml
—
5
14
13
64
2.08
1.56
1.2
1.1
—
—
—
0
0
27
170
1.65
1.55
4.4
4.6
0.17
0.00
%
—
6
29
68
862
0.73
1.51
3.1
3.3
40.64
40.55
mg/l
0.00
44
552
71
884
0.74
1.39
3.9
3.9
8.11
6.36
mg/mmol
0.22
47
543
54
410
1.39
1.31
1.6
1.9
—
—
—
0
0
29
197
1.52
1.25
2.4
2.0
72.96
65.46
e9/l
0.36
20
149
28
190
1.52
1.21
1.4
1.1
—
—
—
0
0
79
952
0.77
1.20
3.1
3.2
—
—
—
0
0
41
302
1.41
1.19
1.6
1.5
—
—
—
0
0
76
919
0.77
1.18
3.6
3.2
7.42
7.62
mmol/l
0.14
67
773
5
20
2.52
1.15
1.4
1.2
—
—
—
0
0
5
20
2.52
1.15
1.8
2.0
—
—
—
0
0
5
21
2.40
1.09
3.8
1.5
453.60
813.67
mg
—
5
21
7
33
2.15
1.06
1.6
1.4
—
—
—
0
0
5
22
2.29
1.04
1.0
1.2
—
—
—
0
0
7
34
2.08
1.03
2.6
2.1
3.90
4.15
mmol/l
—
7
34
7
34
2.08
1.03
2.6
2.1
1.20
1.18
mmol/l
—
7
34
7
34
2.08
1.03
2.6
2.1
107.29
105.41
mmol/l
—
7
34
25
173
1.49
1.01
1.2
1.3
—
37.20
—
0
14
5
23
2.19
0.98
6.2
2.0
13.24
10.81
%
—
5
23
0
29
0.00
0.98
0.0
1.3
—
0.34
—
0
23
0
29
0.00
0.98
0.0
1.3
—
2.75
—
0
23
0
29
0.00
0.98
0.0
1.3
—
5.77
—
0
23
7
36
1.97
0.97
1.9
1.3
—
—
—
0
0
14
219
0.62
0.94
1.5
1.3
—
—
—
0
0
73
610
1.26
0.92
2.3
2.1
3.47
2.77
mg/l
0.93
64
518
38
291
1.35
0.90
4.6
2.9
4.13
4.45
e9/l
0.27
31
244
6
29
2.09
0.90
1.2
1.3
—
—
—
0
0
72
603
1.26
0.89
2.4
2.5
331.52
350.80
umol/l
0.83
60
528
46
572
0.77
0.88
1.2
1.4
0.62
1.72
u/ml
—
6
150
112
986
1.22
0.88
4.4
3.6
582.63
138.25
ng/l
0.37
79
691
29
214
1.39
0.86
2.0
1.8
0.00
0.00
estimate
—
9
41
28
208
1.38
0.81
3.6
2.3
11.89
14.77
nmol/l
1.11
23
195
0
24
0.00
0.79
0.0
1.2
—
188.13
—
0
24
0
26
0.00
0.79
0.0
1.0
—
—
—
0
0
0
28
0.00
0.76
0.0
1.3
—
—
—
0
0
5
24
2.10
0.75
3.0
1.6
10.60
11.13
mmol/l
—
5
24
81
702
1.21
0.73
5.5
3.5
0.00
0.00
estimate
-0.00
30
215
7
40
1.77
0.71
5.3
2.0
—
—
—
0
0
36
444
0.79
0.66
2.6
2.6
0.50
0.78
ug/l
3.29
24
270
10
62
1.63
0.66
1.0
1.2
—
—
—
0
0
7
44
1.60
0.65
1.4
1.9
—
—
—
0
0
43
517
0.80
0.63
2.8
1.3
2.11
2.48
g/l
0.66
25
314
68
777
0.84
0.60
4.8
3.9
3.70
1.86
ug/l
0.56
60
696
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
3.2
—
—
—
0
0
16
116
1.40
0.55
1.7
1.9
0.00
7.81
estimate
—
7
32
9
60
1.52
0.55
13.3
3.5
—
—
—
0
0
52
597
0.84
0.49
5.6
3.6
1.02
1.02
kg/l
0.05
31
374
7
110
0.63
0.49
1.0
1.1
—
14.20
—
0
5
115
1060
1.14
0.48
5.0
3.2
6.38
6.20
ph
0.97
69
598
139
1298
1.13
0.47
5.8
3.5
0.03
0.00
estimate
0.49
31
236
21
264
0.78
0.47
2.2
1.7
—
—
—
0
0
118
1093
1.13
0.45
2.7
2.5
78.20
77.02
nmol/l
0.16
107
990
26
211
1.25
0.45
2.3
2.1
32.43
30.97
u/l
0.06
21
172
140
1311
1.13
0.45
5.9
3.5
0.00
0.00
estimate
-0.00
32
240
12
163
0.73
0.45
1.3
1.2
—
—
—
0
0
141
1324
1.12
0.43
6.1
3.5
0.00
0.00
estimate
0.50
31
223
6
92
0.65
0.43
1.2
1.2
—
—
—
0
0
5
33
1.52
0.41
1.4
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
16.21
—
0
15
19
150
1.28
0.41
5.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
231917.20
—
0
10
20
247
0.80
0.40
1.2
1.5
—
—
—
0
0
78
711
1.13
0.38
5.8
2.9
0.00
0.00
estimate
-0.00
28
183
42
479
0.86
0.38
4.1
3.9
30.17
254.46
ng/l
2.16
35
369
20
163
1.24
0.35
8.5
3.0
—
—
—
0
0
104
1110
0.90
0.34
2.2
2.1
89.98
96.35
pmol/l
0.78
55
545
220
2262
0.90
0.33
6.1
5.0
1.92
1.90
mu/l
0.10
202
2082
11
83
1.34
0.32
6.8
7.4
—
—
—
0
0
15
119
1.27
0.32
3.8
4.7
—
—
—
0
0
15
120
1.26
0.30
2.3
1.8
—
—
—
0
0
8
64
1.26
0.27
1.5
1.3
—
—
—
0
0
8
65
1.24
0.27
1.1
1.2
—
—
—
0
0
106
1003
1.09
0.26
5.9
3.4
0.00
0.02
estimate
0.74
26
194
15
123
1.23
0.26
1.1
1.1
—
—
—
0
0
66
615
1.09
0.23
1.3
1.4
—
—
—
0
0
5
40
1.25
0.22
2.0
1.4
—
—
—
0
0
5
42
1.19
0.21
2.6
2.0
64.80
60.90
%
—
5
42
0
11
0.00
0.21
0.0
1.1
—
109.95
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
9.85
—
0
5
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
0.64
—
0
7
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
164.36
—
0
14
6
51
1.18
0.19
3.3
2.2
56.17
16.54
u/ml
—
6
40
6
51
1.18
0.19
4.3
3.7
0.62
0.83
nmol/l
—
6
44
19
217
0.87
0.19
1.2
1.2
—
—
—
0
0
6
53
1.13
0.19
1.7
1.6
128.50
129.05
g/l
—
6
39
55
516
1.08
0.17
5.7
4.2
—
—
—
0
0
8
72
1.11
0.16
3.1
1.9
248.50
216.61
pmol/l
—
8
66
44
471
0.92
0.16
1.6
1.3
16.91
31.98
iu/ml
1.50
15
130
6
80
0.74
0.15
7.0
1.5
—
—
—
0
0
9
79
1.14
0.15
1.0
1.3
—
120.00
—
0
5
7
89
0.78
0.14
1.3
1.4
—
—
—
0
0
167
1632
1.05
0.14
3.5
3.3
64.55
45.34
u/l
0.96
160
1556
22
200
1.11
0.12
2.7
2.0
5.72
6.04
ph
—
9
126
10
115
0.87
0.11
1.4
1.8
—
—
—
0
0
53
509
1.05
0.09
2.0
1.8
0.88
1.14
mg/l
0.86
41
390
31
328
0.94
0.08
1.5
1.2
—
—
—
0
0
7
67
1.05
0.08
5.6
1.9
—
—
—
0
0
52
501
1.05
0.07
1.8
1.7
202273155.91
440.07
pmol/l
0.49
44
427
236
2379
0.96
0.07
25.1
13.0
24.29
22.85
mg/l
0.26
214
1903
9
100
0.90
0.06
1.1
1.1
—
—
—
0
0
22
207
1.07
0.06
1.6
1.8
—
—
—
0
0
188
1899
0.97
0.06
5.5
4.0
15.04
14.73
pmol/l
0.84
177
1730
112
1139
0.97
0.06
3.0
2.8
130.45
117.35
ug/l
0.24
105
1075
33
344
0.95
0.05
1.7
1.4
626.67
495.17
titre
—
6
87
22
232
0.94
0.05
1.2
1.4
—
—
—
0
0
19
182
1.05
0.02
3.8
4.0
69.96
80.08
ng/l
0.29
13
161
43
439
0.98
0.02
1.4
1.3
23.55
9.68
u/ml
0.33
14
165
32
312
1.03
0.02
2.4
2.6
106.20
105.82
ug/g
0.00
25
254
41
402
1.02
0.01
1.9
1.7
1294.59
1177.88
nmol/l
0.30
34
309
13
128
1.02
0.00
1.0
1.1
—
—
—
0
0
11
115
0.95
0.00
1.4
1.2
—
—
—
0
0
12
124
0.97
0.00
2.7
2.3
—
—
—
0
0
16
164
0.97
0.00
1.3
1.2
173.74
123.76
u/ml
—
5
63
19
186
1.02
0.00
3.1
2.3
0.31
0.37
e6/l
0.08
19
174
25
246
1.02
0.00
1.3
1.4
—
—
—
0
0
70
705
0.99
0.00
1.8
1.7
21.79
20.44
nmol/l
0.28
59
604
0
7
0.00
-0.00
0.0
4.9
—
7.53
—
0
7
9
93
0.97
-0.00
5.0
1.5
—
—
—
0
0
9
95
0.95
-0.00
5.3
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
12.6
—
4.88
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
76.20
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
74.67
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
0.00
—
0
5
9
93
0.97
-0.00
5.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
3.33
—
0
6
0
6
0.00
-0.00
0.0
3.8
—
37.67
—
0
6
5
50
1.00
-0.00
1.4
1.0
0.15
1.92
u/ml
—
5
28
7
79
0.88
-0.00
1.3
1.1
0.91
0.92
g/l
—
7
79
7
79
0.88
-0.00
1.3
1.1
1.48
1.52
g/l
—
7
79
9
89
1.01
-0.00
5.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.7
—
11.67
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
13.38
—
0
5
9
93
0.97
-0.00
5.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_SPINAL_CORD_CRANIAL_AND_OTHER_CNS_WIDE – Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system, including Hilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).