Colorectal neuroendocrine tumor and carcinoma, excluding all cancers (controls excluding all cancers)

C3_COLORECTAL_NEUROENDO_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C1[8-9]|C20
  • Cancer registry: Morphology ICD-O-3 8240|8246|8249
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

488

4. Check minimum number of events

None

488

5. Include endpoints

None

488

6. Filter based on genotype QC (FinnGen only)

488

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Colorectal neuroendocrine tumor and carcinoma, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 488 312 176
Unadjusted period prevalence (%) 0.10 0.11 0.08
Median age at first event (years) 50.63 46.54 57.87

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
442
Matched controls
4419
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8240/3-C18.2
ICD-O-3
Neuroendocrine tumor, NOS, of ascending colon
+∞
149.7
135
*
8240/3-C18.1
ICD-O-3
Neuroendocrine tumor, NOS, of appendix
+∞
146.2
132
*
8240/3-C20.9
ICD-O-3
Neuroendocrine tumor, NOS, of rectum, NOS
+∞
104.4
96
*
130
Kela drug reimbursment
Malignant tumour
+∞
78.5
73
*
JFB30
NOMESCO Finland
Right hemicolectomy
195.8
51.1
52
*
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
10.2
50.3
106
132
JEA01
NOMESCO Finland
Laparoscopic appendectomy
15.1
42.4
72
56
C18.19
ICD-10 Finland
Malignant tumor in appendix other or unspecified histology
+∞
40.2
38
*
JN4BD
NOMESCO Finland
Extensive body CT
11.5
38.3
74
76
UJF32
NOMESCO Finland
Coloscopy
4.2
38.0
182
625
H02AB02
ATC
dexamethasone; systemic
44.2
36.0
44
11
C18.09
ICD-10 Finland
Malignant tumor of caecum other or unspecified histology
+∞
35.9
34
*
JEA00
NOMESCO Finland
Appendectomy
8.7
35.7
81
111
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
15.8
34.5
57
41
E34.0
ICD-10 Finland
Carcinoid syndrome
363.7
34.4
34
*
C17.9
ICD-10 Finland
Malignant neoplasm: Small intestine, unspecified
+∞
33.8
32
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
6.9
31.6
84
145
A04AA02
ATC
granisetron; systemic, transdermal
323.3
30.2
30
*
JFB31
NOMESCO Finland
Laparoscopic right hemicolectomy
89.0
30.2
33
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
28.4
27
*
D37.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Appendix
+∞
27.4
26
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
26.3
25
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
26.3
25
*
C18.99
ICD-10 Finland
Malignant tumor in unspecified location in the colon other or unspecified histology
+∞
25.2
24
*
A03FA01
ATC
metoclopramide; systemic, rectal
4.3
25.0
103
291
C61
ICD-10 Finland
Malignant neoplasm of prostate
264.3
24.9
25
*
H01CB03
ATC
lanreotide; parenteral
137.8
24.9
26
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.1
24.7
84
194
L01BC06
ATC
capecitabine; oral
+∞
24.2
23
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
23.4
151
613
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
18.9
23.0
35
20
JN4CD
NOMESCO Finland
Very extensive body CT
22.9
22.5
32
15
C18.01
ICD-10 Finland
Malignant tumor of the caecum invasive carcinoma
+∞
22.1
21
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
22.1
21
*
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
230.9
21.8
22
*
C18.90
ICD-10 Finland
Malignant tumor in unspecified location in the colon without histology
+∞
21.0
20
*
C18.00
ICD-10 Finland
Malignant tumor of the caecum without histology
+∞
19.9
19
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
19.1
195
1030
WX302
NOMESCO Finland
Thoracal epidural anesthesy
9.6
19.1
39
44
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
18.9
18
*
JN7AQ
NOMESCO Finland
Somatostatin receptor SPET med low dose CT
+∞
18.9
18
*
115
Kela drug reimbursment
Breast cancer
+∞
18.9
18
*
H01CB02
ATC
octreotide; parenteral
104.5
18.7
20
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
17.8
17
*
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
66.0
16.9
19
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
66.0
16.9
19
*
8240/3-C18.0
ICD-O-3
Neuroendocrine tumor, NOS, of cecum
+∞
16.8
16
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
15.7
15
*
D12.1
ICD-10 Finland
Benign neoplasm: Appendix
165.6
15.6
16
*
JN4AD
NOMESCO Finland
Body CT examination
7.4
15.2
36
52
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
14.7
14
*
C17.2
ICD-10 Finland
Malignant neoplasm: Ileum
+∞
14.7
14
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
14.7
14
*
C18.10
ICD-10 Finland
Malignant tumor of the appendix without histology
+∞
14.7
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
13.6
71
238
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
13.6
13
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
13.6
13
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
144.2
13.5
14
*
XX3DW
NOMESCO Finland
Time consuming IT work
4.9
12.8
42
93
D37.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Small intestine
72.0
12.7
14
*
JN5ER
NOMESCO Finland
PET-CT of receptors in whole body
133.6
12.5
13
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.3
12.4
64
213
JFB20
NOMESCO Finland
Ileocaecal resection
38.7
12.3
15
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
11.5
11
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
11.5
11
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
11.5
11
*
C18.0
ICD-10 Finland
Malignant neoplasm: Caecum
+∞
11.5
11
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
123.1
11.5
12
*
B01AB05
ATC
enoxaparin; parenteral
2.2
11.1
136
743
D37.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Colon
18.4
10.8
16
9
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
112.6
10.5
11
*
XX9AN
NOMESCO Finland
Complementary isotope examination or additional picture
112.6
10.5
11
*
15301
ICD-8 Finland
Malignant neoplasm of large intestine, except rectum, Appendicis
+∞
10.5
10
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
10.5
10
*
XX7JT
NOMESCO Finland
Somatostatin isotope ablative therapy
+∞
10.5
10
*
C18.11
ICD-10 Finland
Malignant tumor of the appendix invasive carcinoma
+∞
10.5
10
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
10.5
10
*
116
Kela drug reimbursment
Prostate cancer
+∞
10.5
10
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
10.5
10
*
8249/3-C18.0
ICD-O-3
Neuroendocrine tumor, grade 2 of cecum
+∞
10.5
10
*
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
11.0
10.4
19
18
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
5.9
10.3
28
50
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
10.0
90
420
WF002
NOMESCO Finland
Radical radiotherapy
41.0
10.0
12
*
ZX120
NOMESCO Finland
Intravenous
3.7
9.7
42
122
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
4.1
9.5
36
93
L03AA13
ATC
pegfilgrastim; parenteral
102.1
9.4
10
*
K62.1
ICD-10 Finland
Rectal polyp
30.7
9.4
12
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
9.4
9
*
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
+∞
9.4
9
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
9.4
9
*
Z51.5
ICD-10 Finland
Palliative care
9.8
9.3
18
19
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.6
9.3
42
126
WX402
NOMESCO Finland
General anaesthesia
2.6
9.0
70
302
B01AB10
ATC
tinzaparin; parenteral
4.3
9.0
32
78
R4110
NOMESCO Finland
Physiotherapy
2.1
8.9
116
640
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
7.6
8.5
19
26
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
3.7
8.5
36
103
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
91.7
8.4
9
*
P01AB01
ATC
metronidazole; oral, rectal
1.9
8.4
178
1177
D75
ICPC
Malignant neoplasm colon/rectum
+∞
8.4
8
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
8.4
8
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.3
8.0
39
125
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
8.0
128
762
N02AA05
ATC
oxycodone; systemic
2.6
7.6
55
227
HAB40
NOMESCO Finland
Wedge excision of mammary gland
25.5
7.6
10
*
A04AA01
ATC
ondansetron; systemic, rectal
5.5
7.5
21
40
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
7.3
7
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
7.3
7
*
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
+∞
7.3
7
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
7.3
7
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
7.3
7
*
C18.79
ICD-10 Finland
Malignant tumor of the sigmoid or other unspecified histology
+∞
7.3
7
*
8246/3-C18.1
ICD-O-3
Neuroendocrine carcinoma, NOS, of appendix
+∞
7.3
7
*
D77
ICPC
Malignant digestive neopl other/NOS
+∞
7.3
7
*
C18.20
ICD-10 Finland
Malignant tumor of the ascending colon without histology
+∞
7.3
7
*
C18.91
ICD-10 Finland
Malignant tumor of unspecified location in colon invasive carcinoma
+∞
7.3
7
*
C18.1
ICD-10 Finland
Malignant neoplasm: Appendix
+∞
7.3
7
*
HA1AA
NOMESCO Finland
X-ray mammography
4.8
7.3
23
50
K37
ICD-10 Finland
Unspecified appendicitis
20.4
7.2
10
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
7.0
171
1166
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.9
6.9
123
759
L02BG04
ATC
letrozole; oral
7.0
6.6
15
22
UJF92
NOMESCO Finland
Capsular endoscopy
6.3
6.5
16
26
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
6.5
99
574
L03AA02
ATC
filgrastim; parenteral
70.8
6.4
7
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
70.8
6.4
7
*
A04AD12
ATC
aprepitant; systemic
70.8
6.4
7
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
6.4
85
469
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.9
6.4
37
135
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
18.3
6.3
9
5
JAH01
NOMESCO Finland
Laparoscopy
4.1
6.3
23
59
A79
ICPC
Malignancy NOS
+∞
6.3
6
*
C18.29
ICD-10 Finland
Malignant tumor of the ascending colon or other unspecified histology
+∞
6.3
6
*
L01CB01
ATC
etoposide; systemic
+∞
6.3
6
*
1535C
ICD-9 Finland
Malignant neoplasm of colon, Appendix[NEOPL MALIG APPEND VERMIF,MUU TAI MÄÄRITTELEMÄTÖN H]
+∞
6.3
6
*
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
6.3
6
*
L01AX03
ATC
temozolomide; systemic
+∞
6.3
6
*
WD205
NOMESCO Finland
Therapy of methastized malignancy with hormones
+∞
6.3
6
*
C18.21
ICD-10 Finland
Malignant tumor of the ascending colon invasive carcinoma
+∞
6.3
6
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
6.3
6
*
JN7AN
NOMESCO Finland
Somatostatin receptor isotope imaging
+∞
6.3
6
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
6.3
6
*
8249/3-C20.9
ICD-O-3
Neuroendocrine tumor, grade 2 of rectum, NOS
+∞
6.3
6
*
JG1CG
NOMESCO Finland
Extensive MRI of rectum
+∞
6.3
6
*
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
+∞
6.3
6
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
6.3
6
*
NK6AN
NOMESCO Finland
Total body bone isotope imaging
27.1
6.2
8
*
L02AE02
ATC
leuprorelin; implant, parenteral
12.7
6.1
10
8
6421
FHL
Appendicectomy
2.9
6.0
35
128

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
114
97
15.03
116.77
1.4
1.3
—
—
—
0
0
113
9
162.81
110.48
5.8
1.1
124.50
68.11
nmol/l
—
113
9
119
171
8.88
82.69
4.6
1.5
9.77
4.42
ug/l
0.53
100
135
103
300
4.08
31.75
1.2
1.1
—
—
—
0
0
118
396
3.61
29.47
1.7
1.3
—
—
—
0
0
292
1825
2.49
21.19
8.0
3.6
11.08
10.99
umol/l
0.06
281
1710
195
1039
2.46
19.81
2.4
1.9
—
—
—
0
0
253
1553
2.31
18.15
5.9
3.6
35.90
36.19
g/l
0.41
240
1432
36
70
5.47
17.96
2.2
1.9
109.57
169.97
u/ml
0.19
30
58
77
266
3.25
17.85
2.2
1.9
0.23
0.21
g/l
1.46
72
245
386
2921
2.54
15.93
10.1
5.2
79.96
74.65
u/l
1.23
375
2695
210
1255
2.18
15.38
2.2
1.7
—
—
—
0
0
302
2091
2.17
14.97
10.3
6.1
4.13
4.18
e9/l
0.13
262
1827
250
1657
2.04
13.37
4.5
3.5
—
—
—
0
0
193
1211
1.98
11.61
2.6
2.1
59.12
56.41
u/l
0.35
178
1112
189
1198
1.94
10.89
4.5
2.0
2.35
2.35
mmol/l
0.20
170
1003
85
399
2.37
10.72
2.2
2.1
5.71
5.81
umol/l
0.03
77
342
139
800
2.03
10.51
2.3
1.9
—
—
—
0
0
147
870
1.99
10.23
7.6
4.6
—
—
—
0
0
121
672
2.06
10.03
2.4
2.5
545.75
540.02
mosm/kgh2o
0.10
104
570
87
438
2.20
9.24
2.3
2.5
18.85
24.55
%
4.45
77
371
212
1452
1.81
9.20
9.1
8.4
1.16
1.26
inr
1.09
72
420
184
1220
1.82
8.80
6.8
5.4
—
—
—
0
0
243
1750
1.77
8.77
7.7
5.7
8.51
8.37
%
0.29
222
1639
241
1740
1.76
8.55
7.5
5.4
2.96
2.97
%
0.03
220
1621
245
1778
1.76
8.54
7.2
5.2
56.55
56.81
%
0.13
224
1668
155
983
1.85
8.52
2.7
2.8
0.27
0.42
e6/l
0.75
117
733
246
1791
1.75
8.44
7.6
5.5
28.80
28.65
%
0.07
225
1674
190
1291
1.77
8.25
3.3
3.4
20.43
86.89
e6/l
4.02
132
897
233
1678
1.74
8.25
7.7
5.4
0.71
0.71
%
0.04
213
1563
165
1079
1.80
8.14
2.9
2.9
41.77
115.59
e6/l
0.61
126
822
11
14
8.02
8.02
1.1
1.2
—
—
—
0
0
257
1924
1.71
7.74
7.3
5.2
2.00
1.93
e9/l
0.25
218
1707
150
966
1.80
7.72
2.6
2.7
—
—
—
0
0
317
2518
1.74
7.64
4.1
4.1
8.20
3288.51
e6/l
—
5
35
96
537
1.98
7.64
2.4
2.3
10.92
14.16
umol/l
5.06
89
490
259
1948
1.70
7.63
7.4
5.5
0.20
0.20
e9/l
0.22
220
1725
183
1256
1.73
7.52
3.1
2.5
29.35
30.84
u/l
0.43
170
1195
135
852
1.81
7.39
4.5
3.6
—
—
—
0
0
251
1889
1.68
7.24
7.3
5.2
0.04
0.04
e9/l
0.92
209
1643
249
1876
1.67
7.11
7.4
5.2
0.59
0.58
e9/l
0.35
208
1624
112
687
1.82
6.66
4.6
2.1
2.45
2.43
mmol/l
0.96
104
588
118
739
1.79
6.54
2.4
2.2
4.84
7.10
e6/l
1.02
100
648
228
1704
1.63
6.54
13.4
7.8
0.00
0.00
e9/l
0.41
187
1395
279
2197
1.63
6.44
5.5
4.0
6.55
6.68
mmol/l
0.59
269
2034
219
1626
1.63
6.41
6.5
4.8
1.21
1.22
mmol/l
0.16
206
1452
237
1798
1.62
6.33
7.1
5.3
1.21
1.22
mmol/l
0.37
186
1543
153
1062
1.64
5.74
4.9
3.0
7.40
7.40
ph
0.25
44
174
43
204
2.21
5.25
1.5
1.2
—
—
—
0
0
80
482
1.79
4.98
3.0
2.2
131.38
114.76
ug/g
0.21
67
377
439
4001
1.97
4.92
18.0
11.3
26.15
21.13
mg/l
2.22
372
3055
316
2660
1.53
4.76
3.4
2.9
58.75
44.35
u/l
1.19
296
2494
131
917
1.59
4.61
2.5
2.1
3.09
2.96
mg/l
0.28
117
763
50
265
1.99
4.60
6.7
6.7
—
—
—
0
0
7
5
14.17
4.59
2.4
1.0
26.14
14.20
u/ml
—
7
5
318
2696
1.52
4.50
4.0
4.0
—
—
—
0
0
57
321
1.88
4.40
3.6
3.3
—
—
—
0
0
79
499
1.70
4.15
1.6
1.9
—
—
—
0
0
47
253
1.95
4.15
1.2
1.3
—
—
—
0
0
85
549
1.66
4.11
1.3
1.2
—
—
—
0
0
86
559
1.65
4.06
2.2
2.7
2.88
2.78
e6/l
0.03
43
290
67
409
1.74
3.98
1.3
1.5
—
—
—
0
0
49
274
1.88
3.88
3.3
4.5
0.75
0.88
%
0.15
12
58
23
96
2.46
3.78
3.0
3.1
—
—
—
0
0
50
287
1.83
3.65
5.2
5.6
1.57
1.35
mmol/l
0.74
50
277
133
978
1.49
3.65
1.5
1.4
—
—
—
0
0
17
63
2.76
3.52
3.6
2.8
—
—
—
0
0
46
261
1.84
3.49
3.5
4.6
0.10
0.06
%
—
10
52
445
4153
1.81
3.48
19.7
13.4
139.64
139.76
mmol/l
0.53
438
4040
236
1947
1.41
3.46
4.6
4.7
0.00
0.00
estimate
0.50
55
348
446
4167
1.82
3.45
19.9
13.5
3.93
3.97
mmol/l
2.04
437
4047
14
47
3.04
3.44
1.4
1.3
—
—
nmol/l
—
0
0
15
53
2.89
3.38
1.3
1.3
—
—
—
0
0
339
2988
1.44
3.37
4.0
4.1
12.16
11.34
mm/h
0.48
322
2752
233
1938
1.39
3.17
3.4
3.4
0.00
0.00
estimate
0.00
52
351
24
112
2.20
3.12
1.5
1.3
241.62
325.22
ug/g
1.02
17
62
235
1978
1.36
2.88
3.4
3.4
0.00
0.01
estimate
0.50
54
339
369
3343
1.43
2.85
21.6
13.6
13.82
13.58
%
2.19
364
3275
43
257
1.74
2.78
3.3
4.5
0.50
0.40
%
—
8
45
42
255
1.71
2.58
3.5
4.6
0.00
2.00
%
—
8
47
142
1124
1.37
2.50
3.7
3.7
—
—
—
0
0
16
70
2.33
2.43
1.1
1.2
—
—
—
0
0
16
70
2.33
2.43
3.2
3.0
2.10
3.00
mmol/l
—
10
44
135
1072
1.36
2.31
3.2
3.1
—
—
—
0
0
57
386
1.54
2.29
1.9
2.2
1.83
1.74
%
0.28
46
345
37
226
1.69
2.25
3.3
1.4
—
—
—
0
0
444
4221
1.58
2.20
17.3
10.9
—
—
—
0
0
130
1036
1.35
2.17
3.7
3.6
0.00
0.01
estimate
0.88
53
345
109
845
1.37
2.16
4.5
4.3
—
—
—
0
0
110
855
1.37
2.15
1.8
1.6
0.84
0.94
mg/l
0.23
91
631
74
538
1.44
2.12
1.4
1.5
—
—
—
0
0
49
328
1.55
2.09
4.9
3.2
2.56
2.12
mmol/l
0.30
37
260
202
1722
1.30
2.07
3.6
2.7
95.14
108.47
ug/l
0.70
192
1585
59
412
1.49
2.07
1.6
1.7
—
—
—
0
0
7
20
3.54
2.06
1.1
1.1
—
—
—
0
0
108
844
1.36
2.04
1.6
1.7
67778170.94
15938374.03
pmol/l
0.34
90
709
9
32
2.85
2.01
1.1
1.6
—
—
—
0
0
72
528
1.43
1.97
2.2
1.8
30.11
29.63
s
0.30
72
511
451
4323
1.57
1.90
13.6
8.6
27.38
26.01
u/l
0.96
440
4160
310
2827
1.26
1.72
4.5
3.7
—
—
—
0
0
19
104
1.86
1.69
2.5
1.6
—
—
—
0
0
179
1534
1.26
1.69
3.2
3.2
—
—
—
0
0
12
55
2.21
1.68
1.0
1.0
23.21
7.13
u/ml
—
5
33
13
62
2.13
1.67
4.0
1.3
—
—
—
0
0
189
1636
1.25
1.63
2.1
2.0
90.26
96.94
pmol/l
1.26
112
808
5
14
3.60
1.62
1.0
1.4
—
—
—
0
0
14
70
2.03
1.60
3.3
2.4
16.27
16.16
%
—
6
34
174
1494
1.26
1.60
3.9
3.5
35.46
62.24
ng/l
0.53
119
1014
18
100
1.83
1.55
1.1
1.1
—
—
—
0
0
188
1639
1.24
1.50
2.8
2.3
74.71
77.75
nmol/l
0.73
171
1452
92
736
1.31
1.48
1.6
1.7
1289.50
1207.48
nmol/l
0.35
71
564
12
60
2.03
1.39
1.2
1.1
0.40
1.70
u/ml
—
5
24
5
17
2.96
1.36
1.8
1.8
—
—
—
0
0
12
61
1.99
1.34
4.4
2.4
—
—
—
0
0
40
287
1.43
1.28
2.3
2.6
65.55
70.14
e9/l
0.32
25
223
19
115
1.68
1.26
3.5
1.4
10.33
10.51
g/l
0.05
19
103
130
1108
1.24
1.25
3.6
2.9
1145.57
1185.51
ng/l
0.04
104
923
20
125
1.63
1.19
1.5
1.1
—
—
—
0
0
8
38
2.12
1.19
4.0
2.8
—
—
—
0
0
118
1002
1.23
1.17
2.3
2.2
7776.34
7771.33
umol/l
0.00
100
868
13
72
1.83
1.16
3.8
3.1
4.65
4.45
e9/l
0.10
13
72
5
20
2.51
1.15
5.6
2.5
—
—
—
0
0
110
930
1.24
1.14
1.5
1.5
20.67
21.53
nmol/l
0.24
101
801
8
40
2.02
1.12
2.1
2.3
—
—
—
0
0
13
73
1.80
1.12
4.1
3.5
60.77
58.79
%
0.22
13
73
462
4507
1.47
1.11
26.7
16.9
256.69
252.42
e9/l
0.78
453
4395
7
31
2.28
1.10
2.1
1.5
12.37
10.08
%
—
7
31
22
144
1.55
1.10
1.4
1.2
—
—
—
0
0
462
4510
1.46
1.07
26.6
16.9
4.47
4.52
e12/l
1.43
452
4385
10
52
1.94
1.07
1.9
2.7
—
—
—
0
0
462
4511
1.45
1.06
26.7
16.9
6.72
6.64
e9/l
0.38
453
4388
60
477
1.29
1.04
1.5
1.7
—
—
—
0
0
11
60
1.85
1.03
3.4
1.3
—
—
—
0
0
5
106
0.47
1.02
1.2
1.2
—
—
—
0
0
30
217
1.41
0.96
1.5
1.7
—
—
—
0
0
81
680
1.23
0.91
1.7
1.9
—
—
—
0
0
6
29
2.08
0.89
2.7
1.1
—
—
—
0
0
6
29
2.08
0.89
1.0
1.1
—
—
—
0
0
48
380
1.29
0.88
1.4
1.4
—
—
—
0
0
6
30
2.01
0.87
1.7
1.4
—
—
—
0
0
8
44
1.83
0.86
1.3
1.2
—
—
—
0
0
8
138
0.57
0.84
4.0
10.1
—
—
—
0
0
8
46
1.75
0.83
1.6
1.8
93.04
89.88
%
—
8
46
6
32
1.89
0.82
5.0
2.7
—
—
—
0
0
167
1511
1.16
0.82
2.8
2.8
—
—
—
0
0
391
3768
1.19
0.80
5.0
4.7
1.87
2.20
mu/l
0.51
357
3466
0
25
0.00
0.79
0.0
1.5
—
9.78
—
0
18
35
270
1.32
0.78
3.5
2.5
4.11
3.91
e9/l
0.15
26
214
128
1138
1.17
0.78
2.7
2.9
—
—
—
0
0
15
99
1.53
0.76
5.0
3.9
—
—
—
0
0
11
67
1.66
0.75
1.5
1.4
—
—
—
0
0
38
299
1.29
0.75
4.6
3.4
140.67
173.01
ng/l
0.38
33
281
10
60
1.68
0.72
1.5
1.4
—
—
—
0
0
12
76
1.59
0.72
4.4
2.7
8.22
8.16
kpa
0.05
12
71
13
85
1.54
0.69
4.7
2.9
26.63
24.93
mmol/l
0.88
13
76
20
144
1.41
0.69
1.1
1.2
37.09
26.80
iu/l
0.46
15
121
10
61
1.65
0.69
1.3
2.3
—
—
—
0
0
5
93
0.53
0.67
1.6
1.3
0.60
1320.44
e6/l
—
5
73
5
93
0.53
0.67
1.6
1.2
11.20
5.01
e6/l
—
5
71
22
162
1.37
0.67
1.2
1.1
—
—
—
0
0
40
323
1.26
0.66
6.0
6.8
116.77
122.79
g/l
1.12
40
313
10
62
1.63
0.65
1.4
1.5
—
—
—
0
0
5
29
1.73
0.64
3.6
2.6
—
—
—
0
0
47
389
1.23
0.63
6.6
6.4
1.12
1.54
mmol/l
0.58
42
304
57
482
1.21
0.63
24.2
23.5
1.60
1.30
inr
—
9
71
21
156
1.36
0.62
8.8
4.0
—
—
—
0
0
381
3690
1.15
0.61
18.2
12.4
40.29
40.18
%
0.13
284
2668
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
15.0
—
1625.05
—
0
20
0
20
0.00
0.60
0.0
10.7
—
853.95
—
0
20
0
20
0.00
0.60
0.0
1.2
—
165.42
—
0
20
46
383
1.22
0.59
1.4
1.4
—
—
—
0
0
20
264
0.75
0.59
2.4
2.7
—
—
—
0
0
102
916
1.14
0.56
3.2
3.4
—
—
—
0
0
12
82
1.48
0.55
2.3
2.4
—
—
—
0
0
14
99
1.43
0.54
2.6
2.4
20.87
99.74
ug/min
—
7
58
409
4182
0.86
0.54
4.9
5.0
2.69
2.78
mmol/l
1.25
386
3882
9
61
1.48
0.54
1.0
1.3
—
—
—
0
0
6
39
1.55
0.53
1.3
1.1
—
—
—
0
0
63
719
0.86
0.51
1.3
1.3
11.87
9.09
u/ml
0.10
26
264
7
46
1.53
0.48
2.0
2.3
32.29
33.65
pg
—
7
46
7
49
1.43
0.46
1.9
2.2
—
—
—
0
0
7
50
1.41
0.45
1.9
2.2
108.00
105.46
mmol/l
—
7
50
7
50
1.41
0.45
1.9
2.2
3.67
4.05
mmol/l
—
7
50
41
349
1.19
0.45
2.4
2.0
323.69
366.50
nmol/l
0.83
35
319
391
3817
1.12
0.45
5.9
5.8
39.39
39.71
mmol/mol
0.32
364
3564
17
130
1.32
0.44
1.8
1.9
684.93
272.53
ug/l
0.45
17
121
24
193
1.26
0.44
3.8
3.3
—
—
—
0
0
403
4111
0.89
0.43
4.3
4.5
4.65
4.69
mmol/l
0.35
380
3828
68
758
0.88
0.41
1.3
1.3
11.50
33.46
iu/ml
5.31
24
229
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
28.91
—
0
11
5
37
1.35
0.37
2.0
1.6
0.36
0.47
nmol/l
—
5
32
14
108
1.31
0.35
1.6
1.7
3.37
5.23
iu/l
—
6
37
25
297
0.83
0.35
1.2
1.2
157.20
144.67
iu/ml
—
10
116
34
293
1.17
0.34
4.4
3.7
103.39
77.67
ng/l
0.68
28
261
32
275
1.18
0.33
1.2
1.2
—
—
—
0
0
20
164
1.23
0.33
6.2
8.9
—
—
—
0
0
20
165
1.22
0.31
1.6
1.8
—
—
—
0
0
402
4084
0.91
0.30
4.2
4.4
1.44
1.49
mmol/l
1.77
377
3793
35
306
1.15
0.30
1.5
1.4
—
—
—
0
0
7
54
1.30
0.30
1.6
1.2
—
—
—
0
0
24
203
1.19
0.30
2.7
2.3
—
—
—
0
0
8
62
1.30
0.28
1.0
1.1
—
—
—
0
0
8
64
1.25
0.27
2.0
1.9
69.13
59.77
%
—
8
64
35
310
1.14
0.26
3.3
3.0
—
—
—
0
0
11
138
0.79
0.26
3.6
3.6
24.81
24.84
mmol/l
0.01
11
130
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
7
93
0.75
0.22
1.4
1.2
3.74
3.80
mmol/l
—
7
86
14
116
1.21
0.22
1.1
1.4
79.13
259.87
miu/ml
—
8
55
86
911
0.93
0.21
3.6
3.6
1.02
1.02
kg/l
0.52
11
131
0
11
0.00
0.21
0.0
1.1
—
0.66
—
0
5
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
14.19
—
0
10
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
8
102
0.78
0.21
1.3
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
8
105
0.76
0.21
1.5
1.3
419.87
424.16
mg/l
—
8
96
15
176
0.85
0.20
1.2
1.1
—
76.57
titre
—
0
7
36
329
1.10
0.18
1.1
1.2
—
—
—
0
0
87
914
0.94
0.17
1.3
1.3
1.05
2.07
u/ml
0.92
22
245
7
63
1.11
0.17
1.0
1.1
—
—
—
0
0
136
1312
1.05
0.17
2.9
3.1
7.82
7.44
mmol/l
0.41
112
1110
15
173
0.86
0.17
1.1
1.1
—
—
—
0
0
5
69
0.72
0.17
2.2
1.6
—
—
—
0
0
6
79
0.76
0.15
1.3
1.2
—
—
—
0
0
14
161
0.87
0.15
1.0
1.2
—
0.99
—
0
12
12
102
1.18
0.15
1.2
1.7
27.67
38.82
nmol/l
2.37
12
97
20
179
1.12
0.14
1.2
1.7
—
14.68
—
0
5
125
1212
1.04
0.13
2.9
3.2
472.76
222.30
mg/l
0.23
77
757
25
229
1.10
0.12
5.8
4.7
—
—
—
0
0
16
144
1.11
0.10
1.6
1.6
—
—
—
0
0
16
144
1.11
0.10
1.6
1.6
—
—
—
0
0
390
3928
0.96
0.09
3.8
4.0
1.41
1.29
mmol/l
1.94
360
3621
16
145
1.11
0.09
1.6
1.6
—
—
—
0
0
16
145
1.11
0.09
1.7
1.6
—
—
—
0
0
44
461
0.95
0.09
2.0
1.4
—
—
—
0
0
6
54
1.11
0.09
1.0
1.2
—
—
—
0
0
39
410
0.95
0.09
1.3
1.4
—
—
—
0
0
77
747
1.04
0.08
3.6
3.9
27.87
334.44
ng/l
2.61
52
567
7
66
1.06
0.08
1.0
1.1
—
—
—
0
0
6
74
0.81
0.07
2.2
1.6
—
—
—
0
0
8
76
1.05
0.07
7.0
7.0
107.25
105.56
mmol/l
—
8
71
8
76
1.05
0.07
7.0
7.0
10.13
10.75
mmol/l
—
8
71
404
4018
1.03
0.07
4.8
4.5
5.99
5.92
mmol/l
0.53
380
3681
10
89
1.13
0.07
1.7
2.0
—
—
—
0
0
11
99
1.11
0.06
1.2
1.2
—
—
—
0
0
57
557
1.03
0.04
2.6
2.5
0.67
0.72
ug/l
0.36
42
356
112
1134
0.98
0.03
1.7
1.7
1.51
1.39
mmol/l
0.73
96
961
15
159
0.94
0.03
3.8
3.3
—
—
—
0
0
103
1017
1.02
0.03
4.9
3.6
1.88
1.92
ug/l
0.06
89
908
122
1213
1.01
0.01
2.0
2.1
119.38
186.52
u/l
4.03
117
1144
12
114
1.05
0.00
1.3
1.1
—
—
—
0
0
15
144
1.04
0.00
5.1
4.8
1.61
1.60
%
0.01
15
138
36
366
0.98
0.00
1.7
1.7
—
—
—
0
0
11
115
0.96
0.00
1.8
1.5
—
—
—
0
0
15
146
1.03
0.00
1.6
1.6
—
—
—
0
0
14
137
1.02
0.00
1.6
1.6
—
—
—
0
0
35
354
0.99
0.00
5.2
3.6
—
—
—
0
0
78
776
1.01
0.00
1.3
1.3
2.31
2.46
g/l
0.31
39
458
56
557
1.01
0.00
1.4
1.4
360.00
556.95
titre
0.85
12
131
36
362
0.99
0.00
2.8
2.4
9.01
6.72
ug/l
0.26
31
314
14
141
0.99
0.00
5.4
4.8
0.93
0.95
%
0.05
14
135
19
189
1.01
0.00
1.1
1.1
—
—
—
0
0
26
259
1.00
0.00
1.5
1.4
—
—
—
0
0
317
3173
1.00
0.00
4.4
3.9
14.70
14.75
pmol/l
0.13
288
2905
129
1285
1.01
0.00
3.9
4.0
3.74
8.30
mg/mmol
1.78
80
810
0
6
0.00
0.00
0.0
5.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
1.84
—
0
6
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
7
74
0.95
0.00
1.4
1.7
—
—
—
0
0
7
75
0.93
0.00
1.6
1.4
—
—
—
0
0
7
78
0.90
0.00
1.9
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
17.79
—
0
9
0
8
0.00
0.00
0.0
2.5
—
50.25
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
1.2
1.2
—
—
—
0
0
7
75
0.93
0.00
1.7
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
5.4
—
—
—
0
0
7
76
0.92
0.00
2.3
1.3
—
—
—
0
0
6
63
0.95
0.00
1.2
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
5
49
1.02
0.00
1.0
1.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_COLORECTAL_NEUROENDO_EXALLC – Colorectal neuroendocrine tumor and carcinoma, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).