Transient global amnesia

AMN2

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G45.4
  • Cause of death: ICD-10 G45.4

2 out of 7 registries used, show all original rules.

3388

4. Check minimum number of events

None

3388

5. Include endpoints

None

3388

6. Filter based on genotype QC (FinnGen only)

3388

Control definitions (FinnGen only)

Control exclude
F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G45
Name in latin
Amnesia globalis transitoria

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 22018 13919 8054
Only index persons 21181 13464 7717
Unadjusted period prevalence (%)
Whole population 0.33 0.40 0.23
Only index persons 0.42 0.49 0.29
Median age at first event (years)
Whole population 65.05 65.94 63.49
Only index persons 64.81 65.69 63.29

-FinnGen-

Key figures

All Female Male
Number of individuals 3388 2113 1275
Unadjusted period prevalence (%) 0.66 0.72 0.56
Median age at first event (years) 64.38 64.51 64.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3020
Matched controls
30198
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G45.4
ICD-10 Finland
Transient global amnesia
+∞
323.0
3020
26
AA1AD
NOMESCO Finland
CT of head and brain
4.1
256.8
1385
5189
R41.3
ICD-10 Finland
Other amnesia
14.3
203.5
359
282
N06DX01
ATC
memantine; oral
37.3
94.9
122
34
N06DA02
ATC
donepezil; oral
43.3
94.0
117
28
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.3
80.8
453
1522
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.7
78.6
382
1145
G30.1
ICD-10 Finland
Alzheimer disease with late onset
15.5
64.7
108
72
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
57.5
55
*
P20
ICPC
Memory disturbance
2.6
56.0
477
2062
N06DA03
ATC
rivastigmine; oral, transdermal
31.6
55.7
74
24
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
75.7
46.1
52
7
R41.0
ICD-10 Finland
Disorientation, unspecified
4.4
37.8
141
329
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
23.5
35.7
51
22
N06DA04
ATC
galantamine; oral
41.5
33.1
41
10
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.4
31.7
283
1235
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
29.9
285
1286
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
156.5
29.7
31
*
F03
ICD-10 Finland
Unspecified dementia
7.6
29.6
70
94
R51.80
ICD-10 Finland
Headache
1.9
24.7
393
2194
SPAT1053
SPAT
Memory test
1.7
23.9
510
3141
G30.8
ICD-10 Finland
Other Alzheimer disease
21.5
23.4
34
16
A98
ICPC
Health maint/preventive medicine
2.0
23.3
2826
26506
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
20.7
855
6229
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.2
20.6
228
1100
R42
ICD-10 Finland
Dizziness and giddiness
1.6
19.8
690
4823
R41.2
ICD-10 Finland
Retrograde amnesia
40.3
19.5
24
6
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.5
19.3
161
675
P70
ICPC
Dementia
8.2
17.7
39
48
103
Kela drug reimbursment
Diabetes, insulin-treated
0.7
15.8
434
6174
A10BA02
ATC
metformin; oral
0.7
15.8
468
6561
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
9.2
15.6
32
35
XA400
NOMESCO Finland
EEG
7.0
15.6
38
55
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.3
14.7
135
597
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.9
14.5
212
1145
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.8
13.9
91
336
C10AA05
ATC
atorvastatin; oral
1.3
13.5
1221
10104
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
2.2
13.4
134
617
R53
ICD-10 Finland
Malaise and fatigue
1.5
13.0
520
3711
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.1
12.9
142
683
R55
ICD-10 Finland
Syncope and collapse
1.6
12.8
312
1977
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
1.9
12.7
187
1011
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
130.5
12.4
13
*
G44.2
ICD-10 Finland
Tension-type headache
1.6
12.4
331
2149
B01AC07
ATC
dipyridamole; systemic
2.1
12.4
146
726
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.4
11.8
623
4686
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
1.9
11.8
169
907
Z01.8
ICD-10 Finland
Other specified special examinations
1.4
11.8
593
4422
G45
ICD-10 Finland
Transient cerebral ischaemic attacks and related syndromes
4.5
11.7
40
89
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
11.4
1305
11097
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
11.3
720
5589
A02BC05
ATC
esomeprazole; systemic
1.3
11.3
1129
9412
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
0.7
11.2
397
5435
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.5
11.1
86
352
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
0.4
10.8
49
1154
A10BB01
ATC
glibenclamide; oral
0.3
10.7
19
677
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
2.3
10.5
99
448
L15
ICPC
Knee symptom/complaint
1.4
10.4
619
4747
215
Kela drug reimbursment
Diabetes, non-insulin-treated
0.7
10.3
408
5490
K89
ICPC
Transient cerebral ischaemia
3.6
10.3
44
122
N03AF02
ATC
oxcarbazepine; oral
2.4
10.2
88
379
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.6
10.0
259
1667
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.4
10.0
512
3821
A10BB12
ATC
glimepiride; oral
0.5
10.0
70
1412
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
0.5
9.9
93
1717
H11.3
ICD-10 Finland
Conjunctival haemorrhage
2.0
9.7
125
646
TAB00
NOMESCO Finland
Lumbar puncture
2.2
9.6
100
473
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
9.6
871
7121
N02BE01
ATC
paracetamol; systemic, rectal
1.4
9.6
2501
23536
G30.0
ICD-10 Finland
Alzheimer disease with early onset
+∞
9.4
9
*
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
9.3
1720
15408
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.1
9.2
106
523
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
9.1
418
3052
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.7
9.1
200
1231
A10AE04
ATC
insulin glargine; parenteral
0.5
9.0
89
1621
SPAT1153
SPAT
Removal of sutures
1.3
9.0
952
7934
G54.4
ICD-10 Finland
Lumbosacral root disorders, not elsewhere classified
7.4
8.9
20
27
C10AA07
ATC
rosuvastatin; oral
1.3
8.9
733
5899
T90
ICPC
Diabetes non-insulin dependent
0.7
8.8
409
5372
SPAT1312
SPAT
General health counselling
1.3
8.7
826
6778
J01AA02
ATC
doxycycline; systemic
1.3
8.7
2203
20434
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.5
8.6
276
1869
SPAT1263
SPAT
Sampling
1.3
8.5
1139
9763
R01AD09
ATC
mometasone; nasal
1.3
8.5
1070
9107
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
1.8
8.3
132
737
N06AX11
ATC
mirtazapine; oral
1.3
8.2
787
6461
G47.3
ICD-10 Finland
Sleep apnoea
1.4
8.2
504
3873
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.5
8.1
299
2088
C10AA01
ATC
simvastatin; oral
1.2
8.1
1375
12102
M01AE01
ATC
ibuprofen; systemic, rectal
1.3
8.1
2440
23011
F01.9
ICD-10 Finland
Vascular dementia, unspecified
8.9
8.0
16
18
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.5
7.9
258
1755
A02BC03
ATC
lansoprazole; oral
1.3
7.8
831
6905
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
2.5
7.8
57
227
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.2
7.8
1218
10606
F06.7
ICD-10 Finland
Mild cognitive disorder
2.4
7.7
60
249
E11
ICD-10 Finland
Type 2 diabetes mellitus
0.7
7.7
239
3357
M54.5
ICD-10 Finland
Low back pain
1.3
7.7
799
6622
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
7.6
828
6891
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.5
7.6
278
1942
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.7
7.5
155
940
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.2
7.5
1177
10240
M79.6
ICD-10 Finland
Pain in limb
1.3
7.4
935
7920
A02BC02
ATC
pantoprazole; systemic
1.2
7.3
1847
16906
N17
ICPC
Vertigo/dizziness
1.4
7.3
315
2270
L82
ICD-10 Finland
Seborrhoeic keratosis
1.4
7.3
456
3506
XA800
NOMESCO Finland
Neuropsychological investigation
2.1
7.3
81
396
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2.5
7.3
55
226
I49.3
ICD-10 Finland
Ventricular premature depolarization
1.6
7.3
185
1188
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
1.6
7.2
170
1068
B01AC04
ATC
clopidogrel; oral
1.3
7.1
447
3443
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
1.4
7.0
280
1991
M01AX05
ATC
glucosamine; oral
1.3
6.9
677
5553
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
6.9
1128
9831
M01AE02
ATC
naproxen; oral, rectal
1.2
6.9
1414
12623
N02CC04
ATC
rizatriptan; oral
1.9
6.9
101
553
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.4
6.8
415
3178
K30
ICD-10 Finland
Functional dyspepsia
1.5
6.8
269
1907
N03AX14
ATC
levetiracetam; systemic
2.2
6.8
68
319
G43.9
ICD-10 Finland
Migraine, unspecified
1.9
6.8
88
459
D19
ICPC
Teeth/gum symptom/complaint
1.3
6.7
565
4537
G04CB02
ATC
dutasteride; oral
1.6
6.7
149
927
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
6.7
795
6676
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
6.7
773
6473
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.1
6.7
67
316
M01AC06
ATC
meloxicam; systemic, rectal
1.2
6.6
996
8592
SPAT1260
SPAT
Consultation of another employee
1.3
6.6
464
3634
J01CA04
ATC
amoxicillin; systemic
1.2
6.5
2109
19687
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
0.5
6.5
48
951
H02
ICPC
Hearing complaint
1.4
6.5
360
2718
L08
ICPC
Shoulder symptom/complaint
1.3
6.5
515
4104
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
2.4
6.4
50
210
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.2
6.4
1249
11062
A04
ICPC
Weakness/tiredness general
1.4
6.4
315
2331
SPAT1301
SPAT
No procedures
1.2
6.3
856
7290
S06.0
ICD-10 Finland
Concussion
1.5
6.3
219
1513
H53.1
ICD-10 Finland
Subjective visual disturbances
1.6
6.3
156
995
G45.3
ICD-10 Finland
Amaurosis fugax
2.3
6.3
55
245
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
26.7
6.2
8
*
PA7BD
NOMESCO Finland
CT angiography of neck and brain
2.3
6.2
56
251
SPAT1325
SPAT
Vaccination
1.2
6.2
999
8667
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
0.5
6.2
35
756
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
2.2
6.2
56
252
I10
ICD-10 Finland
Essential (primary) hypertension
1.2
6.2
1800
16571
SPAT1310
SPAT
Counselling related to known health issue
1.2
6.2
838
7138
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
6.1
1487
13443
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
1.5
6.1
199
1360
N27
ICPC
Fear of neurological disease other
2.6
6.1
40
153
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.3
6.0
532
4297
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
6.0
439
3453
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.2
6.0
982
8522
J01FA10
ATC
azithromycin; systemic
1.2
6.0
1360
12200

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1537
9680
2.08
90.90
2.2
2.1
151.68
194.75
u/l
2.33
1478
9000
1772
12025
1.99
82.28
3.8
3.9
28.11
85.11
ng/l
0.97
1351
9038
2286
18050
1.82
55.55
4.2
4.6
6.40
6.78
mmol/l
24.55
2166
16955
835
4896
1.94
54.54
1.8
2.0
29.03
29.87
s
3.41
811
4743
3145
28262
2.57
45.78
15.4
16.1
22.26
24.82
mg/l
4.00
2525
22710
3256
30042
3.15
39.87
18.6
19.0
139.97
139.63
mmol/l
13.32
3225
29280
1718
13233
1.61
38.90
9.9
10.1
1.26
1.30
inr
0.92
473
3674
3253
30107
3.02
37.49
18.8
19.2
3.97
3.98
mmol/l
2.89
3213
29312
2932
26315
1.85
32.22
5.5
5.1
2.00
2.05
mu/l
0.55
2670
23596
3284
30890
3.06
30.10
23.8
24.0
30.38
30.39
pg
0.12
3259
30353
3284
30890
3.06
30.10
23.8
24.0
91.24
91.61
fl
5.53
3259
30353
3284
30892
3.05
30.06
23.9
24.1
4.49
4.41
e12/l
18.50
3227
29852
3284
30895
3.05
30.00
23.9
24.1
6.46
6.73
e9/l
10.95
3229
29853
3284
30899
3.05
29.91
24.0
24.2
135.67
133.27
g/l
19.84
3258
30381
3282
30886
3.00
29.57
24.0
24.1
239.48
247.58
e9/l
11.66
3233
29963
3085
28332
1.99
28.95
5.3
5.2
5.82
6.03
mmol/l
30.56
2809
25372
3132
28924
2.10
28.83
5.9
5.5
2.67
2.68
mmol/l
0.42
2865
26141
3071
28207
1.95
28.09
5.2
4.9
4.57
4.61
mmol/l
1.37
2823
25604
3221
30222
2.33
26.00
11.2
11.6
24.78
24.93
u/l
0.14
3096
28959
3128
29032
2.01
25.90
15.8
15.5
—
—
—
0
0
3041
27975
1.85
25.76
5.2
4.8
1.48
1.49
mmol/l
0.81
2780
25196
2956
27014
1.74
25.00
4.6
4.3
1.26
1.29
mmol/l
1.64
2691
24064
2504
22017
1.53
24.69
4.3
4.4
11.15
14.08
mm/h
24.29
2314
20159
2973
27246
1.74
24.46
5.9
6.4
39.31
40.47
mmol/mol
10.06
2728
24831
470
2895
1.72
24.08
2.4
2.4
5.97
7.01
ug/l
0.76
413
2541
2493
21980
1.51
23.52
4.5
4.2
14.90
15.06
pmol/l
2.61
2256
19620
2278
19904
1.44
21.01
5.3
4.9
1659.27
2017.31
e6/l
0.10
33
283
623
4493
1.47
15.77
24.4
27.6
1.38
1.39
inr
0.05
94
631
812
6227
1.40
14.55
5.0
4.5
1.02
1.02
kg/l
0.28
129
959
1848
16187
1.31
13.19
5.8
6.7
1.22
1.22
mmol/l
1.18
1569
13591
2546
23458
1.34
11.97
7.1
7.9
76.86
80.15
u/l
3.60
2377
21954
384
2649
1.51
11.91
3.9
3.6
—
—
—
0
0
961
7790
1.33
11.63
4.9
4.5
0.00
0.00
estimate
0.23
281
2598
2256
20483
1.30
11.46
5.0
4.7
—
—
—
0
0
1688
14768
1.29
11.43
5.1
5.9
1.21
1.21
mmol/l
0.31
1506
13259
1638
14300
1.28
11.19
4.3
4.0
0.00
0.00
estimate
0.00
276
2668
863
6970
1.32
10.54
4.9
4.6
22.08
21.77
%
0.26
435
3652
104
524
2.02
10.09
1.1
1.2
3.64
3.87
mmol/l
1.65
96
491
1158
9769
1.28
10.09
4.3
4.3
—
—
—
0
0
1651
14563
1.26
9.85
4.3
4.1
0.00
0.00
estimate
1.08
280
2642
1633
14386
1.26
9.85
5.4
5.4
0.00
0.00
estimate
0.00
286
2687
1042
8709
1.28
9.68
5.7
5.4
2.55
3.17
ug/l
1.32
943
7760
1141
9686
1.27
9.25
2.6
2.6
62.33
58.06
u/l
1.13
1042
8842
775
6275
1.30
9.10
4.1
3.9
152.43
489.49
ng/l
1.42
627
5274
1905
17192
1.25
8.90
3.0
3.2
44.50
53.89
u/l
4.15
1747
15596
1283
11138
1.24
8.34
4.1
3.8
—
5.67
—
0
9
96
514
1.89
7.89
1.2
1.4
13.29
33.30
e6/l
0.78
77
381
2418
22543
1.25
7.88
21.3
21.5
332.47
331.22
g/l
10.40
2409
22376
734
6004
1.28
7.83
1.8
1.7
1157.61
1189.99
nmol/l
0.44
546
4433
771
6346
1.28
7.82
1.7
1.7
1.24
1.38
mg/l
0.37
586
4933
96
516
1.89
7.80
1.3
1.4
1707.18
1054.70
e6/l
0.23
84
415
693
5671
1.28
7.31
1.3
1.2
1.91
1.54
u/ml
0.20
174
1414
259
1825
1.45
7.21
2.4
2.5
28.00
22.77
au/ml
—
9
62
2278
21203
1.23
7.01
4.5
4.2
—
—
—
0
0
1482
13245
1.21
6.84
2.1
2.0
100.84
95.36
pmol/l
3.67
730
6520
1412
12563
1.21
6.82
2.2
2.2
80.20
80.53
nmol/l
0.17
1214
10995
88
485
1.84
6.67
1.2
1.4
—
—
—
0
0
30
106
2.85
6.52
2.3
2.0
52.86
55.48
umol/l
0.19
22
80
785
6600
1.25
6.50
2.5
2.6
4.19
5.59
e6/l
3.18
692
5764
541
4358
1.29
6.41
1.2
1.3
—
—
—
0
0
36
142
2.55
6.35
1.0
1.0
327.70
269.32
ng/l
0.55
27
91
1176
10333
1.21
6.33
2.9
3.1
996.65
1493.67
ng/l
7.98
1024
8978
218
1525
1.46
6.33
2.2
2.2
12.50
12.31
nmol/l
0.12
199
1316
1393
12473
1.20
6.06
2.3
2.2
—
—
—
0
0
232
1661
1.43
5.96
1.3
1.3
44.17
52.80
au/ml
—
6
73
35
142
2.48
5.85
1.0
1.0
844.62
830.02
ng/l
0.07
26
88
1560
14167
1.19
5.66
3.8
4.2
—
—
—
0
0
1148
10155
1.20
5.59
3.4
3.4
—
—
—
0
0
28
108
2.61
5.22
1.0
1.3
—
70.47
%
—
0
17
1762
16243
1.18
5.16
5.5
6.4
11.54
11.59
umol/l
0.08
1651
15405
272
2051
1.35
5.16
1.2
1.2
—
—
—
0
0
818
7071
1.21
5.02
4.6
4.0
—
—
—
0
0
424
3425
1.27
4.88
4.0
4.4
—
—
—
0
0
257
1947
1.35
4.74
2.6
3.2
3.99
4.09
e9/l
0.26
190
1420
2399
22797
1.18
4.49
18.4
19.9
13.64
13.84
%
12.37
2367
22248
1204
10859
1.17
4.41
2.9
3.5
2.35
2.36
mmol/l
2.09
1015
9251
593
5030
1.22
4.37
3.4
3.2
0.72
0.79
ug/l
0.82
433
3576
147
1031
1.45
4.31
1.7
1.9
20.52
21.86
s
2.01
127
915
777
6771
1.19
4.29
1.7
1.7
27170921.79
26891044.77
pmol/l
0.00
622
5448
199
1476
1.37
4.24
1.9
2.5
0.65
0.65
%
0.01
191
1408
137
955
1.45
4.16
10.4
10.6
—
—
—
0
0
20
74
2.71
4.08
1.3
1.2
0.71
0.73
umol/24h
0.05
11
34
2556
24497
1.18
3.99
16.8
17.6
39.47
38.70
%
2.96
1576
15670
1080
9731
1.16
3.91
3.7
4.1
7.40
7.40
ph
0.04
179
1867
151
1104
1.38
3.56
1.9
2.2
154.25
508.79
ug/l
5.11
146
1041
0
91
0.00
3.48
0.0
11.2
—
0.63
—
0
84
853
7615
1.16
3.42
1.5
1.5
21.18
20.92
nmol/l
0.18
703
6342
488
4159
1.20
3.41
5.2
4.9
32.86
33.34
%
0.43
333
2647
1597
14892
1.14
3.39
5.0
5.9
1.82
1.90
e9/l
1.07
1401
12897
1475
13693
1.14
3.34
4.2
4.8
35.50
34.95
g/l
3.90
1359
12638
1568
14646
1.13
3.17
4.9
5.8
0.04
0.04
e9/l
2.62
1371
12440
1615
15125
1.13
3.10
4.9
6.0
0.18
0.19
e9/l
1.74
1425
13063
1178
10822
1.14
3.08
3.9
3.8
90.11
124.79
e6/l
0.57
890
7731
1558
14568
1.13
3.06
4.9
5.8
0.56
0.60
e9/l
8.77
1359
12363
15
355
0.42
3.01
1.3
1.5
—
—
—
0
0
817
7341
1.15
2.96
3.6
3.8
—
—
—
0
0
561
4902
1.17
2.94
1.3
1.3
29.89
38.54
iu/ml
1.10
167
1544
11
35
3.15
2.93
1.1
1.2
1.53
1.77
umol/24h
0.59
11
35
90
625
1.45
2.89
1.2
1.1
9.02
7.33
u/ml
—
5
44
1813
17153
1.12
2.84
7.5
9.3
3.96
4.13
e9/l
2.50
1601
14861
37
633
0.58
2.82
3.5
3.8
19.48
32.92
u/ml
1.48
37
618
919
8355
1.14
2.78
3.1
3.2
—
—
—
0
0
252
2053
1.25
2.77
1.2
1.3
—
—
—
0
0
230
1855
1.26
2.76
2.5
2.5
—
—
—
0
0
113
829
1.38
2.69
1.1
1.1
—
—
—
0
0
530
4644
1.17
2.69
1.3
1.2
10.61
13.71
u/ml
0.49
208
1664
102
736
1.40
2.68
1.4
1.4
—
—
—
0
0
185
1459
1.28
2.68
1.3
1.3
—
—
—
0
0
1021
9368
1.13
2.65
3.3
3.3
134.76
65.13
e6/l
0.74
814
7197
151
1162
1.31
2.63
1.2
1.2
—
—
—
0
0
52
803
0.64
2.62
2.2
2.3
196.43
87.63
ug/min
0.61
32
474
16
343
0.46
2.54
1.3
1.5
—
—
—
0
0
396
4579
0.85
2.50
2.2
2.5
2.35
2.30
g/l
0.93
363
4241
168
1324
1.28
2.47
4.1
4.5
—
—
—
0
0
41
248
1.66
2.46
2.0
2.0
3.09
3.32
ug/l
0.12
35
213
119
1566
0.75
2.46
1.8
1.7
1.35
1.56
g/l
1.62
96
1363
372
4305
0.85
2.38
2.3
2.6
23.16
21.80
%
0.93
308
3656
186
1492
1.26
2.38
1.2
1.3
132.31
197.10
u/ml
1.73
179
1358
5
8
6.26
2.37
1.2
1.0
—
—
—
0
0
947
8704
1.12
2.35
3.2
3.2
0.16
0.51
e6/l
21.85
748
6576
657
5910
1.14
2.31
4.2
4.8
—
—
—
0
0
24
126
1.91
2.30
1.2
1.4
50.81
70.71
pmol/l
—
8
42
161
1276
1.27
2.28
2.4
2.7
—
—
—
0
0
129
994
1.31
2.27
3.9
6.2
1.26
1.28
mmol/l
0.06
109
879
39
239
1.64
2.25
2.2
2.1
2.08
2.16
ug/l
0.07
33
199
0
62
0.00
2.22
0.0
2.7
—
—
—
0
0
17
80
2.13
2.18
1.1
1.3
—
14.92
%
—
0
13
59
402
1.48
2.17
2.0
2.4
—
—
—
0
0
14
295
0.47
2.16
1.0
1.1
—
—
—
0
0
21
108
1.95
2.15
1.3
1.2
—
—
—
0
0
60
412
1.46
2.12
1.1
1.1
—
—
—
0
0
261
3079
0.83
2.10
1.4
1.4
—
—
—
0
0
21
110
1.91
2.05
2.1
1.4
—
—
—
0
0
21
376
0.56
1.98
1.2
1.1
1.41
1.55
g/l
2.13
21
333
59
411
1.44
1.96
2.0
2.4
107.24
105.31
mmol/l
4.50
59
406
59
411
1.44
1.96
2.0
2.4
4.02
4.06
mmol/l
0.25
59
406
21
374
0.56
1.95
1.6
1.6
—
—
—
0
0
19
98
1.94
1.95
1.7
1.5
79.08
131.56
umol/l
0.66
13
55
25
142
1.77
1.92
1.9
1.9
—
—
—
0
0
674
6148
1.12
1.89
2.7
2.8
547.37
530.83
mosm/kgh2o
1.17
571
5197
356
3117
1.16
1.86
1.9
2.1
159.46
154.51
ug/g
0.07
262
2374
126
998
1.27
1.85
1.4
1.6
—
—
—
0
0
902
8368
1.11
1.84
1.6
1.6
1.32
1.34
mmol/l
0.30
735
6875
73
536
1.37
1.83
1.7
1.6
—
—
—
0
0
96
736
1.31
1.81
1.6
1.8
—
—
—
0
0
558
5052
1.13
1.78
1.4
1.5
2.29
2.58
g/l
2.53
301
2848
23
132
1.75
1.73
1.5
1.3
—
—
—
0
0
102
1297
0.78
1.71
2.6
2.4
10.31
10.32
g/l
0.01
81
1104
441
4916
0.88
1.71
2.2
2.6
13.06
12.35
umol/l
1.19
397
4546
394
3499
1.14
1.71
1.4
1.4
—
—
—
0
0
168
1391
1.22
1.69
2.1
2.0
—
—
—
0
0
23
382
0.60
1.69
1.2
1.5
50814.75
77738.24
e6/l
0.42
16
219
123
986
1.26
1.67
4.2
4.1
3.86
3.87
mmol/l
0.19
118
928
910
8490
1.10
1.65
3.3
3.3
—
—
—
0
0
455
4090
1.13
1.64
5.1
6.4
104.17
104.08
mmol/l
0.15
446
3998
388
3456
1.14
1.62
1.3
1.3
—
—
—
0
0
133
1084
1.24
1.57
1.3
1.2
0.88
1.41
u/ml
0.38
11
110
240
2069
1.17
1.57
6.1
6.8
24.71
24.64
mmol/l
0.13
224
1922
97
762
1.28
1.57
1.1
1.1
—
—
—
0
0
121
977
1.25
1.56
1.6
1.4
279.45
273.07
ug/g
0.14
78
578
27
168
1.61
1.55
5.7
15.1
—
—
—
0
0
25
154
1.63
1.49
1.7
2.1
424.80
618.03
e6/l
—
10
67
170
1430
1.20
1.49
1.1
1.2
—
—
—
0
0
27
170
1.59
1.48
1.9
1.4
—
—
—
0
0
660
6095
1.10
1.47
2.8
3.1
2.45
2.47
mmol/l
3.70
589
5320
10
203
0.49
1.47
1.0
1.1
—
—
—
0
0
317
2808
1.14
1.45
1.5
1.5
—
—
—
0
0
1041
9823
1.09
1.44
2.3
2.5
—
—
—
0
0
94
1177
0.79
1.44
3.4
3.3
36.79
62.03
mg/l
1.11
78
964
1207
11475
1.08
1.38
2.7
2.8
127.80
146.13
ug/l
1.76
1095
10411
26
397
0.65
1.38
1.1
1.2
—
—
—
0
0
15
262
0.57
1.37
1.1
1.3
1.45
1.51
nmol/l
0.12
15
236
95
1180
0.80
1.37
3.3
3.3
54.27
108.31
mg/l
0.55
78
966
92
1146
0.80
1.36
3.4
3.2
21.20
1.71
ratio
—
8
92
87
1088
0.79
1.33
2.8
2.3
39.27
37.35
g/l
2.62
70
940
330
2957
1.13
1.29
2.9
3.6
1.96
2.04
mmol/l
0.14
277
2417
5
18
2.78
1.28
1.0
1.4
—
—
—
0
0
809
7591
1.09
1.28
2.2
2.4
—
—
—
0
0
587
5430
1.10
1.28
2.8
2.8
1.09
1.22
e6/l
0.36
364
3147
38
268
1.42
1.27
1.2
1.4
—
—
—
0
0
8
35
2.29
1.26
2.3
1.5
—
—
—
0
0
25
376
0.66
1.25
1.2
1.3
287.82
202.97
miu/ml
0.34
11
140
44
597
0.73
1.25
2.8
2.9
—
—
—
0
0
218
2483
0.87
1.22
2.3
2.4
—
—
—
0
0
1428
13713
1.07
1.21
5.0
6.1
2.83
2.85
%
0.13
1327
12692
16
93
1.72
1.21
1.2
1.1
—
—
—
0
0
227
1995
1.15
1.21
2.8
3.7
7.43
7.42
ph
1.53
25
260
28
405
0.69
1.17
2.3
2.0
3.50
1106.43
u/ml
0.89
28
393
313
2816
1.12
1.16
4.3
6.3
1.26
1.34
mmol/l
0.86
298
2715
0
36
0.00
1.14
0.0
1.4
—
12.28
—
0
26
5
111
0.45
1.12
1.8
1.8
—
—
—
0
0
32
225
1.43
1.12
1.5
1.5
—
—
—
0
0
951
10008
0.93
1.12
2.9
3.2
149.24
329.82
mg/l
1.27
556
6136
229
2027
1.14
1.11
2.8
3.7
5.11
5.16
kpa
0.51
213
1878
148
1721
0.85
1.11
6.6
8.5
24.37
24.45
mmol/l
0.12
134
1609
40
293
1.37
1.11
1.8
2.0
—
—
—
0
0
57
730
0.78
1.11
3.9
4.5
2.40
2.85
mmol/l
0.77
44
516
46
605
0.76
1.09
3.2
3.8
55.78
57.97
%
0.67
46
605
12
66
1.82
1.09
1.8
2.0
—
—
—
0
0
61
772
0.79
1.08
1.9
1.6
—
—
—
0
0
52
399
1.31
1.08
1.4
1.3
—
—
nmol/l
—
0
0
148
1715
0.86
1.07
4.1
4.1
25.60
72.17
u/ml
5.13
142
1650
1430
13781
1.07
1.06
5.2
6.4
8.69
8.87
%
1.31
1332
12792
41
305
1.35
1.05
1.3
1.2
—
—
—
0
0
823
7788
1.07
1.05
3.6
3.9
89.53
88.25
%
0.71
809
7594
67
834
0.80
1.04
1.4
1.4
—
—
—
0
0
5
22
2.27
1.03
1.4
1.1
—
28.38
—
0
8
26
179
1.46
1.02
3.5
2.9
—
—
—
0
0
13
75
1.74
1.02
1.2
1.1
—
—
—
0
0
13
215
0.60
1.02
1.4
1.3
—
—
—
0
0
118
1386
0.85
1.02
2.4
2.4
7.14
7.54
g/l
1.69
80
1045
159
1383
1.16
1.01
3.5
5.0
0.90
0.88
%
0.34
152
1298
118
1383
0.85
1.00
2.4
2.4
3.39
3.79
g/l
3.99
78
1004
947
9021
1.07
1.00
3.1
3.2
35.97
37.09
u/l
0.11
886
8513
5
110
0.45
1.00
1.4
1.5
0.40
3.34
%
—
5
91
266
2945
0.89
0.99
2.3
2.6
65.55
66.42
g/l
1.02
232
2680
1430
13806
1.06
0.98
5.0
6.0
56.85
57.68
%
1.83
1325
12794
5
23
2.18
0.98
1.2
1.2
—
—
—
0
0
5
23
2.18
0.98
1.4
1.3
—
—
—
0
0
7
36
1.95
0.97
1.0
1.1
—
—
—
0
0
229
2050
1.13
0.96
3.0
3.2
—
—
—
0
0
0
31
0.00
0.96
0.0
1.0
—
8.00
—
0
12
1450
14019
1.06
0.94
5.2
6.2
27.85
27.08
%
1.81
1345
12941
22
150
1.47
0.92
1.2
1.1
8.98
10.79
iu/ml
—
6
38
47
365
1.29
0.92
3.4
5.6
6.78
7.36
mmol/l
0.65
41
309
25
175
1.43
0.92
6.4
6.4
—
—
—
0
0
70
853
0.82
0.92
3.6
4.2
7.42
7.43
ph
0.19
55
720
130
1125
1.16
0.91
1.5
1.4
—
—
—
0
0
59
730
0.80
0.90
2.3
2.9
1.48
1.66
mg/l
1.33
52
650
31
417
0.74
0.90
2.1
1.6
0.66
0.86
g/l
0.71
24
303
158
1390
1.14
0.89
3.5
5.0
1.56
1.58
%
0.18
150
1302
19
127
1.50
0.88
1.9
2.5
—
—
—
0
0
18
119
1.52
0.88
4.8
5.8
71.11
61.02
mg/l
—
9
87
7
129
0.54
0.88
3.7
2.4
—
—
—
0
0
448
4174
1.08
0.87
1.3
1.3
—
—
—
0
0
45
352
1.28
0.85
1.2
1.3
—
—
—
0
0
33
247
1.34
0.85
1.8
2.0
1.04
1.04
e9/l
0.00
20
159
31
230
1.35
0.84
1.7
1.3
—
—
—
0
0
12
190
0.63
0.82
1.2
1.4
—
—
—
0
0
328
3024
1.09
0.82
3.2
3.0
147.78
211.26
ng/l
2.65
308
2758
74
884
0.83
0.82
3.0
3.4
—
—
—
0
0
31
232
1.34
0.81
1.7
1.3
—
—
—
0
0
355
3826
0.92
0.80
3.9
4.1
9.83
28.10
ug/l
2.56
294
3137
1077
10371
1.06
0.79
4.7
5.8
—
—
—
0
0
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
0
27
0.00
0.77
0.0
1.6
—
8.14
—
0
16
12
186
0.64
0.76
1.9
2.6
7.43
7.42
ph
—
5
70
10
59
1.70
0.75
1.2
1.4
87.56
106.07
ng/l
—
10
59
10
59
1.70
0.75
1.2
1.4
—
—
—
0
0
113
1292
0.87
0.75
2.5
2.5
2.79
3.12
g/l
3.89
77
1027
9
54
1.67
0.74
1.1
1.1
—
—
—
0
0
77
652
1.19
0.74
1.1
1.1
—
—
—
0
0
981
10183
0.95
0.72
2.8
3.1
7.00
6.90
mmol/l
0.39
810
8414
336
3123
1.08
0.72
5.6
7.5
121.78
119.52
g/l
1.28
324
3010
113
1285
0.88
0.70
3.1
3.3
931.12
3724.82
u/ml
0.65
88
1075
162
1455
1.12
0.70
2.5
3.8
—
—
—
0
0
131
1474
0.88
0.70
3.2
3.8
24.40
24.29
mmol/l
0.13
112
1312
351
3760
0.93
0.70
2.4
2.5
1.68
1.83
%
2.43
312
3340
86
740
1.17
0.69
2.1
2.2
132.65
125.86
g/l
1.87
69
518
64
537
1.20
0.69
1.3
1.4
—
—
—
0
0
21
285
0.74
0.68
1.1
1.3
—
26.93
—
0
14
33
257
1.29
0.68
2.2
2.3
—
—
—
0
0
9
59
1.53
0.68
8.0
4.9
—
—
—
0
0
1018
10539
0.95
0.68
3.5
4.0
5.14
8.81
mg/mmol
3.11
579
6415
152
1364
1.12
0.67
1.9
1.9
3.56
2.43
ug/l
0.39
130
1213
269
2908
0.92
0.67
2.5
2.6
68.99
70.06
e9/l
0.20
221
2185
23
170
1.36
0.67
1.1
1.1
—
—
—
0
0
95
827
1.15
0.67
2.6
3.2
25.05
25.22
mmol/l
0.17
83
720
5
91
0.55
0.67
1.2
1.3
—
163.15
—
0
44
1373
13356
1.05
0.66
5.1
6.1
0.68
0.68
%
0.02
1276
12372
28
214
1.31
0.66
1.8
1.3
—
—
—
0
0
417
4428
0.93
0.66
1.8
2.0
—
—
—
0
0
5
28
1.79
0.66
1.0
1.0
103.58
76.13
ug/l
—
5
20
94
819
1.15
0.66
1.5
1.6
12806.71
12392.16
e6/l
0.04
66
580
26
197
1.32
0.65
1.5
1.9
19.45
14.83
%
0.49
11
70
284
3058
0.92
0.65
2.0
2.1
0.21
0.21
g/l
0.01
257
2858
54
449
1.21
0.65
1.8
2.2
40.43
22.52
mg/l
0.67
14
110
30
233
1.29
0.64
1.0
1.1
—
—
—
0
0
8
129
0.62
0.63
1.3
1.5
71.50
65.26
%
—
8
103
138
1238
1.12
0.63
2.8
4.0
24.93
25.00
mmol/l
0.10
124
1143
21
155
1.36
0.63
1.3
1.6
0.13
0.17
nmol/l
0.67
14
113
269
2896
0.92
0.62
5.8
6.9
8.95
10.53
mmol/l
3.93
261
2759
30
235
1.28
0.61
1.0
1.1
—
—
—
0
0
16
113
1.42
0.61
1.4
2.2
919.44
1859.38
u/ml
0.89
16
113
121
1080
1.12
0.61
2.9
2.9
0.34
0.29
g/l
0.18
42
420
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
831
8012
1.05
0.58
2.5
2.8
4879.72
5358.29
umol/l
0.12
706
6790
281
2621
1.08
0.58
3.1
3.7
85.78
93.60
ng/l
0.68
236
2209
251
2332
1.08
0.58
1.4
1.4
—
—
—
0
0
11
73
1.51
0.56
1.2
1.0
—
—
—
0
0
158
1731
0.91
0.56
2.0
1.8
1.38
1.46
g/l
0.12
140
1559
31
384
0.81
0.55
2.2
1.9
—
—
—
0
0
353
3331
1.07
0.54
2.9
2.6
8.89
8.57
umol/l
0.11
316
2901
216
2328
0.92
0.54
1.5
1.5
—
—
—
0
0
893
8644
1.04
0.53
3.8
4.3
—
—
—
0
0
29
231
1.26
0.53
1.8
1.3
—
—
—
0
0
16
216
0.74
0.53
1.3
1.2
—
68.00
—
0
5
44
368
1.20
0.53
1.1
1.2
—
—
—
0
0
10
66
1.52
0.52
3.1
1.6
—
—
—
0
0
20
260
0.77
0.52
1.7
1.8
13.14
10.88
%
1.05
20
260
20
152
1.32
0.52
1.0
1.1
—
—
—
0
0
32
392
0.81
0.52
1.1
1.1
284.33
72.17
iu/ml
—
6
72
44
369
1.19
0.52
1.3
1.2
5.41
5.34
u/ml
0.01
22
155
135
1483
0.91
0.52
1.3
1.3
—
—
—
0
0
9
64
1.41
0.51
1.0
1.3
—
—
—
0
0
11
157
0.70
0.51
1.9
2.5
1612.73
1866.72
ml
0.56
11
135
58
670
0.86
0.50
2.2
1.7
6.95
4.47
iu/l
0.75
26
211
35
288
1.22
0.50
1.1
1.1
—
—
—
0
0
23
180
1.28
0.49
1.6
1.3
4.11
1.39
u/ml
—
10
94
7
111
0.63
0.48
1.0
1.1
—
—
—
0
0
17
128
1.33
0.47
1.5
1.2
144.06
141.30
nmol/l
0.07
17
128
12
85
1.41
0.46
1.2
1.2
—
—
—
0
0
28
227
1.24
0.46
1.8
1.3
—
—
—
0
0
30
246
1.22
0.45
5.5
5.0
338.50
82.71
u/ml
—
9
70
32
385
0.83
0.45
1.1
1.3
—
—
—
0
0
282
2664
1.06
0.44
5.3
7.6
—
—
—
0
0
228
2428
0.93
0.44
1.5
1.5
—
—
—
0
0
23
184
1.25
0.43
3.2
3.7
—
—
—
0
0
45
387
1.16
0.42
1.4
1.3
10.46
12.43
u/l
0.52
37
309
82
736
1.12
0.42
4.6
6.8
11.53
10.99
mmol/l
0.77
76
657
82
736
1.12
0.42
4.6
6.8
104.68
105.13
mmol/l
0.45
76
657
21
167
1.26
0.41
2.0
2.0
0.10
0.23
e9/l
0.68
21
162
8
58
1.38
0.41
1.5
1.6
—
—
—
0
0
8
58
1.38
0.41
1.0
1.3
—
—
—
0
0
80
719
1.12
0.41
2.2
2.9
8.05
7.92
kpa
0.43
73
667
0
17
0.00
0.40
0.0
1.5
—
—
—
0
0
20
159
1.26
0.40
1.1
1.1
1.74
2.66
u/ml
—
10
63
399
4162
0.95
0.39
4.6
5.6
1.01
1.04
mmol/l
1.84
371
3861
388
3718
1.05
0.38
1.3
1.3
464.30
560.52
titre
0.57
79
844
61
542
1.13
0.38
1.1
1.2
—
—
—
0
0
13
170
0.76
0.38
2.1
2.3
—
—
—
0
0
66
737
0.89
0.38
3.4
3.8
—
—
—
0
0
167
1784
0.93
0.37
6.2
9.2
—
—
—
0
0
9
69
1.31
0.37
1.4
1.5
—
—
—
0
0
1321
12970
1.03
0.37
9.1
10.2
0.00
0.00
e9/l
2.33
1121
10547
352
3370
1.05
0.37
5.5
7.1
96.07
95.66
%
0.84
341
3246
15
116
1.29
0.37
1.2
1.3
—
0.26
g/l
—
0
11
8
116
0.69
0.37
1.1
1.5
28.63
30.21
umol/l
—
8
111
53
597
0.89
0.36
1.2
1.2
—
—
—
0
0
5
78
0.64
0.35
1.6
1.4
19.78
26.49
g/l
—
5
65
36
310
1.16
0.35
1.2
1.4
138214.48
144005.34
e6/l
0.02
27
207
27
320
0.84
0.35
1.1
1.2
—
—
—
0
0
40
348
1.15
0.34
3.0
4.3
—
—
—
0
0
11
82
1.34
0.34
1.4
2.1
—
—
—
0
0
35
302
1.16
0.34
1.3
1.1
—
—
—
0
0
232
2204
1.06
0.33
4.2
4.6
—
—
—
0
0
22
182
1.21
0.33
1.1
1.3
27.94
41.82
u/l
0.78
17
144
91
836
1.09
0.33
1.2
1.2
—
—
—
0
0
19
155
1.23
0.32
2.2
2.6
33.43
37.74
%
—
7
59
220
2092
1.06
0.31
6.3
8.1
1.33
1.31
%
0.13
220
2080
7
52
1.35
0.31
1.0
1.1
—
—
—
0
0
31
358
0.86
0.31
1.1
1.5
—
—
—
0
0
7
53
1.32
0.30
1.3
1.0
—
—
—
0
0
41
362
1.13
0.30
1.3
1.2
—
—
—
0
0
22
260
0.85
0.29
2.5
1.4
5.55
7.23
g/l
2.21
16
176
22
260
0.85
0.29
2.5
1.4
0.57
0.45
g/l
0.18
16
177
22
260
0.85
0.29
2.5
1.4
2.49
2.91
g/l
0.73
16
179
31
269
1.15
0.29
1.5
2.0
2.00
1.75
u/field
—
9
83
8
110
0.73
0.28
2.4
2.3
—
—
—
0
0
20
167
1.20
0.28
1.1
1.0
1.69
1.89
u/ml
—
7
69
66
603
1.10
0.28
2.2
2.8
28.06
36.31
umol/l
2.64
55
509
56
617
0.91
0.28
1.3
1.5
—
—
—
0
0
67
613
1.09
0.28
2.2
2.9
—
—
—
0
0
8
63
1.27
0.27
9.0
8.2
—
—
—
0
0
176
1673
1.05
0.27
3.2
3.1
4.33
4.39
pmol/l
0.41
155
1452
8
65
1.23
0.27
1.0
1.1
—
—
—
0
0
8
66
1.21
0.26
1.0
1.0
—
—
—
0
0
36
405
0.89
0.26
1.1
1.1
—
—
—
0
0
51
462
1.11
0.26
1.3
1.3
—
—
—
0
0
10
77
1.30
0.26
1.1
1.1
1592.70
1616.34
miu/ml
—
10
77
35
394
0.89
0.26
1.1
1.3
—
—
—
0
0
5
75
0.67
0.25
1.0
1.1
—
—
—
0
0
43
477
0.90
0.25
2.0
2.9
—
—
—
0
0
290
2798
1.04
0.25
3.2
3.9
1.23
1.23
mmol/l
0.19
240
2442
9
76
1.18
0.24
1.0
1.1
—
—
—
0
0
9
76
1.18
0.24
1.0
1.1
—
—
—
0
0
9
76
1.18
0.24
1.0
1.1
—
—
—
0
0
20
170
1.18
0.24
1.6
1.5
1.00
0.96
g/l
0.32
20
170
11
87
1.27
0.24
1.3
1.3
—
—
—
0
0
44
398
1.11
0.24
1.0
1.1
—
—
—
0
0
256
2655
0.96
0.23
1.5
1.5
—
—
—
0
0
388
3771
1.03
0.23
5.2
6.7
12.67
12.19
kpa
0.90
372
3589
388
3771
1.03
0.23
5.2
6.8
5.03
5.11
kpa
0.97
372
3592
13
106
1.23
0.23
1.2
1.1
153.65
242.36
iu/ml
0.81
13
106
12
97
1.24
0.23
1.1
1.5
—
—
—
0
0
12
97
1.24
0.23
1.6
1.8
17.33
102.81
ug/l
0.54
12
87
12
97
1.24
0.23
1.7
1.2
—
—
—
0
0
45
410
1.10
0.22
1.8
1.9
17.22
25.12
ug/l
1.49
45
404
216
2079
1.04
0.22
6.4
8.2
0.74
0.67
%
1.59
216
2067
14
116
1.21
0.22
3.4
3.7
53.18
53.30
%
0.01
14
111
44
401
1.10
0.21
1.3
1.4
113.85
122.17
u/ml
0.26
13
79
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
2.37
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
95
896
1.06
0.21
3.9
4.5
—
—
—
0
0
535
5236
1.03
0.21
2.4
3.2
0.83
0.81
mmol/l
5.62
498
4861
0
13
0.00
0.21
0.0
1.1
—
5.03
—
0
6
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
39
354
1.10
0.20
1.3
1.2
62.35
48.07
u/ml
—
6
25
14
117
1.20
0.20
1.7
1.9
—
—
—
0
0
36
397
0.91
0.20
2.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
337.50
—
0
14
6
49
1.22
0.20
11.7
7.5
—
—
—
0
0
77
819
0.94
0.19
4.1
3.1
0.75
0.83
nmol/l
1.00
69
631
76
715
1.06
0.18
2.2
2.5
16.94
15.75
%
2.26
40
374
16
137
1.17
0.18
1.6
1.9
—
—
—
0
0
16
137
1.17
0.18
1.1
1.2
1.07
1.07
ratio
—
7
35
24
213
1.13
0.18
1.3
2.5
6.81
6.94
mmol/l
0.15
17
140
385
3761
1.03
0.18
5.3
6.8
1.12
1.17
mmol/l
0.09
309
2957
26
233
1.12
0.17
1.4
1.6
—
—
—
0
0
29
262
1.11
0.17
1.2
1.1
0.62
1.29
u/ml
0.91
12
102
64
681
0.94
0.17
3.4
3.7
32.75
27.76
mg/l
0.44
40
414
774
7848
0.98
0.16
2.3
2.3
3.08
3.09
mg/l
0.04
673
6658
30
329
0.91
0.16
1.3
1.4
—
—
—
0
0
30
329
0.91
0.16
1.3
1.4
—
—
—
0
0
30
329
0.91
0.16
1.3
1.4
—
—
—
0
0
30
329
0.91
0.16
1.3
1.4
—
—
—
0
0
511
5020
1.02
0.16
3.1
3.0
2.59
2.69
e6/l
0.09
287
2744
356
3483
1.02
0.15
1.6
1.8
—
—
—
0
0
51
545
0.93
0.15
1.3
1.2
15.77
45.12
u/l
3.67
46
470
9
78
1.15
0.15
1.4
1.5
—
—
—
0
0
37
400
0.92
0.15
1.3
1.5
64.33
60.70
%
0.24
21
252
18
159
1.13
0.15
2.1
2.4
7.98
9.04
mmol/l
1.46
13
126
14
121
1.16
0.15
1.0
1.0
—
3.27
—
0
15
21
234
0.90
0.15
1.0
1.2
355.53
344.48
nmol/l
0.08
15
189
246
2524
0.97
0.15
4.6
4.3
—
—
—
0
0
7
88
0.80
0.14
1.1
1.1
—
—
—
0
0
7
89
0.79
0.14
1.1
1.5
—
—
—
0
0
14
122
1.15
0.13
1.9
1.8
5.64
8.49
%
0.62
14
117
20
222
0.90
0.13
1.1
1.0
0.86
1.32
u/ml
—
8
83
22
199
1.11
0.13
1.4
1.6
—
—
—
0
0
33
356
0.93
0.13
3.0
3.4
—
—
—
0
0
17
151
1.13
0.13
3.8
4.1
—
—
—
0
0
155
1598
0.97
0.13
1.2
1.2
129.58
140.98
iu/ml
0.17
63
566
20
180
1.11
0.13
1.5
1.6
—
—
—
0
0
63
599
1.05
0.12
1.4
1.5
—
—
—
0
0
15
169
0.89
0.12
1.7
1.4
—
—
—
0
0
20
181
1.11
0.12
1.6
1.8
—
8.89
—
0
10
10
116
0.86
0.12
1.4
1.3
—
—
—
0
0
86
828
1.04
0.11
1.8
1.5
1.18
1.18
g/l
0.05
81
783
249
2441
1.02
0.11
3.7
3.9
0.65
0.55
%
0.26
43
570
77
740
1.04
0.11
1.2
1.2
3.49
2.96
u/ml
—
10
82
45
426
1.06
0.10
1.4
1.3
—
—
—
0
0
15
167
0.90
0.10
1.7
2.2
—
—
—
0
0
273
2680
1.02
0.10
3.9
4.1
0.90
0.87
%
0.05
72
799
33
309
1.07
0.10
1.1
1.2
6.88
7.64
mmol/l
0.99
24
220
214
2096
1.02
0.10
6.5
8.2
94.55
93.95
%
1.27
214
2088
11
96
1.15
0.10
1.2
1.3
41.67
32.67
%
—
6
63
731
7241
1.01
0.10
1.3
1.3
—
—
—
0
0
5
47
1.06
0.09
2.6
2.9
—
79.09
—
0
10
5
47
1.06
0.09
1.2
1.8
10.22
9.22
mg/l
—
5
40
5
47
1.06
0.09
1.4
1.5
—
—
—
0
0
20
217
0.92
0.09
2.1
2.7
—
—
—
0
0
30
282
1.06
0.09
1.2
1.0
2.65
2.53
u/ml
—
8
83
42
441
0.95
0.08
2.5
2.5
—
—
—
0
0
5
62
0.81
0.08
1.8
1.1
—
—
—
0
0
7
64
1.09
0.08
1.0
1.0
—
—
—
0
0
21
195
1.08
0.08
1.0
1.1
—
—
—
0
0
17
156
1.09
0.08
1.1
1.1
—
—
—
0
0
7
67
1.04
0.08
5.1
6.6
—
—
—
0
0
17
184
0.92
0.07
1.2
1.3
—
—
—
0
0
9
87
1.03
0.07
1.7
1.7
15.32
15.85
pmol/l
—
9
69
38
397
0.96
0.07
2.3
2.6
—
—
—
0
0
54
559
0.97
0.06
1.4
1.4
0.79
0.79
nmol/l
0.01
47
456
56
579
0.97
0.06
3.3
3.6
1.95
1.39
%
0.58
43
444
28
295
0.95
0.06
1.2
1.5
25.29
29.46
%
0.26
18
182
9
103
0.87
0.06
8.1
6.3
26.58
24.63
mmol/l
—
9
93
77
750
1.03
0.06
1.2
1.2
7.09
6.26
u/ml
0.09
16
133
760
7644
0.99
0.06
5.8
6.9
—
—
—
0
0
41
395
1.04
0.05
1.2
1.2
323.70
285.93
u/ml
0.29
25
232
41
395
1.04
0.05
1.3
1.3
262.68
283.32
pmol/l
0.32
31
302
73
748
0.98
0.05
2.6
2.3
—
—
—
0
0
258
2553
1.01
0.05
4.0
4.1
0.13
0.12
%
0.11
65
742
17
159
1.07
0.05
1.5
1.6
3.78
2.02
u/field
—
9
101
63
646
0.97
0.05
1.3
1.3
68.41
60.80
mmol/l
0.57
46
514
11
120
0.92
0.05
1.0
1.2
47.92
39.92
g/l
—
6
61
36
347
1.04
0.04
3.4
3.6
61.50
58.64
%
0.27
22
215
18
191
0.94
0.04
1.0
1.1
—
—
—
0
0
17
160
1.06
0.04
3.8
3.9
—
—
—
0
0
18
189
0.95
0.03
1.3
1.2
—
—
—
0
0
20
191
1.05
0.03
1.2
1.0
0.41
1.71
u/ml
—
7
54
280
2817
0.99
0.02
2.4
2.3
40.84
38.83
u/l
0.14
254
2403
62
609
1.02
0.02
1.2
1.2
—
—
—
0
0
96
948
1.01
0.02
3.2
3.7
—
—
—
0
0
170
1714
0.99
0.02
3.5
3.7
—
—
—
0
0
29
299
0.97
0.02
2.1
2.9
7.86
26.76
mg/l
2.20
18
217
132
1332
0.99
0.02
2.1
1.5
29.51
19.17
u/ml
—
7
31
53
521
1.02
0.02
2.3
1.4
—
—
—
0
0
260
2613
0.99
0.02
2.3
2.3
368.99
370.45
nmol/l
0.04
233
2384
66
669
0.99
0.01
2.6
2.6
—
—
—
0
0
247
2460
1.00
0.01
1.4
1.6
—
—
—
0
0
11
104
1.06
0.01
1.0
1.0
—
—
—
0
0
10
106
0.94
0.01
2.2
2.3
—
31.40
—
0
5
18
178
1.01
0.00
2.1
1.5
—
—
—
0
0
20
202
0.99
0.00
1.2
1.2
—
—
—
0
0
23
228
1.01
0.00
1.1
1.0
2.26
2.87
u/ml
0.11
11
95
11
105
1.05
0.00
1.3
1.4
2.79
3.17
mmol/l
0.16
11
97
26
258
1.01
0.00
2.5
1.3
—
—
—
0
0
32
325
0.98
0.00
1.2
1.2
—
—
—
0
0
37
365
1.01
0.00
1.0
1.2
—
—
—
0
0
38
375
1.01
0.00
1.6
1.7
—
—
—
0
0
10
99
1.01
0.00
1.1
1.6
1.86
2.04
umol/l
—
10
89
43
426
1.01
0.00
1.3
1.3
37.44
44.83
mu/l
0.28
36
369
24
244
0.98
0.00
1.1
1.2
—
—
—
0
0
18
184
0.98
0.00
1.1
1.1
—
—
—
0
0
10
104
0.96
0.00
2.2
2.2
—
—
—
0
0
14
144
0.97
0.00
1.1
1.0
—
—
—
0
0
217
2168
1.00
0.00
2.9
2.7
10.12
10.61
g/l
0.83
193
1968
77
773
1.00
0.00
2.3
1.9
10.62
11.95
mg/l
0.87
71
706
19
193
0.98
0.00
2.5
2.3
—
—
—
0
0
16
157
1.02
0.00
1.3
1.3
0.83
1.13
nmol/l
—
10
122
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
8
89
0.90
0.00
1.4
1.4
15.25
24.93
%
—
8
74
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
94
940
1.00
0.00
1.6
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
0.00
3.5
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
3776.00
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
154.83
—
0
6
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
239
2390
1.00
0.00
4.1
4.1
0.08
0.35
%
0.80
53
619
0
6
0.00
0.00
0.0
1.0
—
20.62
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
5.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
46.66
—
0
5
0
5
0.00
0.00
0.0
1.6
—
1.49
—
0
5
0
5
0.00
0.00
0.0
1.0
—
25.80
—
0
5
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AMN2 and mortality.

Females

Parameter HR [95% CI] p-value
AMN2 0.684 [0.62, 0.75] < 0.001
Birth year 0.993 [0.99, 1.0] 0.118

During the follow-up period (1.1.1998 — 31.12.2019), 1666 out of 12153 females with AMN2 died.

Males

Parameter HR [95% CI] p-value
AMN2 0.671 [0.61, 0.74] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 1155 out of 7074 males with AMN2 died.

Mortality risk

Mortality risk for people of age

years, who have AMN2.

N-year risk Females Males
1 0.076% 0.124%
5 0.402% 0.704%
10 0.974% 1.922%
15 1.879% 3.694%
20 3.266% 6.373%

Relationships between endpoints

Index endpoint: AMN2 – Transient global amnesia

GWS hits: 10

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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