Scarlet fever

AB1_SCARLET_FEVER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A38
  • Hospital discharge: ICD-9 03[4]
  • Hospital discharge: ICD-8 03[4]
  • Hospital discharge: excluded ICD-9 034[0]
  • Hospital discharge: excluded ICD-8 034[0]
  • Cause of death: ICD-10 A38
  • Cause of death: ICD-9 03[4]
  • Cause of death: ICD-8 03[4]
  • Cause of death: excluded ICD-9 034[0]
  • Cause of death: excluded ICD-8 034[0]

2 out of 7 registries used, show all original rules.

285

4. Check minimum number of events

None

285

5. Include endpoints

None

285

6. Filter based on genotype QC (FinnGen only)

264

Control definitions (FinnGen only)

Control exclude
AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4075 1777 2286
Only index persons 3185 1380 1805
Unadjusted period prevalence (%)
Whole population 0.06 0.05 0.06
Only index persons 0.06 0.05 0.07
Median age at first event (years)
Whole population 7.01 6.65 7.16
Only index persons 7.59 7.19 7.90

-FinnGen-

Key figures

All Female Male
Number of individuals 264 147 117
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 10.84 9.11 13.01

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
269
Matched controls
2690
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
03419
ICD-8 Finland
Streptococcal sore throat and scarlet fever, Scarlatina NUD
+∞
98.1
88
*
A38
ICD-10 Finland
Scarlet fever
+∞
95.7
86
*
03417
ICD-8 Finland
Streptococcal sore throat and scarlet fever, Scarlatina suspecta
+∞
46.2
43
*
0341A
ICD-9 Finland
Streptococcal sore throat and scarlatina, Scarlatina[SCARLATINA STREPTOCOCCUS BETAHAEMOLYTICUS,RYHMÄ-A]
+∞
16.8
16
*
0341X
ICD-9 Finland
Streptococcal sore throat and scarlatina, Scarlatina[SCARLATINA STREPTOCOCCUS BETAHAEMOLYTICUS,MUU]
+∞
15.8
15
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
25.4
14.0
19
8
A46
ICD-10 Finland
Erysipelas
4.2
8.8
24
61
03410
ICD-8 Finland
Streptococcal sore throat and scarlet fever, Scarlatina cum complicatione
+∞
8.4
8
*
A41.9
ICD-10 Finland
Sepsis, unspecified
+∞
7.3
7
*
H02AB09
ATC
hydrocortisone; systemic
8.0
6.2
13
17

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
70
365
2.24
7.20
4.2
3.0
—
—
—
0
0
45
227
2.18
4.92
1.7
1.5
—
—
—
0
0
104
706
1.77
4.73
10.1
6.5
—
—
—
0
0
194
1577
1.83
4.65
9.7
6.6
80.16
78.12
u/l
0.25
185
1505
35
163
2.32
4.62
4.8
2.8
—
—
—
0
0
44
230
2.09
4.39
1.8
1.9
—
—
—
0
0
103
720
1.70
4.11
10.2
7.3
1.10
1.11
inr
0.10
84
584
14
37
3.93
3.95
1.9
3.5
3.79
3.69
e9/l
0.07
14
37
105
749
1.66
3.82
9.1
4.4
37.52
37.99
g/l
0.47
97
724
134
1025
1.61
3.64
15.8
8.8
0.00
0.00
e9/l
0.65
117
832
130
993
1.60
3.52
8.4
5.2
10.21
11.47
umol/l
0.75
122
955
41
229
1.93
3.40
1.5
1.4
—
—
—
0
0
13
43
3.13
3.30
6.2
1.8
7.40
7.42
ph
0.37
13
43
17
66
2.68
3.28
1.0
2.2
—
—
—
0
0
15
57
2.73
3.02
1.9
2.8
55.40
55.87
%
0.06
15
57
31
166
1.98
2.91
5.1
2.6
0.23
0.23
g/l
0.14
31
161
75
522
1.61
2.90
1.8
1.7
—
—
—
0
0
23
111
2.17
2.82
1.2
1.3
—
—
—
0
0
5
6
8.46
2.76
4.6
1.8
—
—
—
0
0
82
590
1.56
2.74
5.1
3.0
0.00
0.00
estimate
0.50
29
212
52
335
1.68
2.71
1.6
1.4
146.67
571.73
titre
4.90
12
75
48
304
1.70
2.66
1.8
1.6
420.25
65018093.42
pmol/l
0.76
40
283
87
640
1.53
2.61
3.1
2.9
13.67
25.90
ng/l
1.50
49
322
33
188
1.86
2.60
2.1
1.6
1452.38
1106.06
nmol/l
1.43
26
150
43
266
1.73
2.59
1.9
3.3
4.07
7.70
e9/l
0.94
35
248
52
345
1.63
2.42
3.9
2.2
473.92
534.39
mosm/kgh2o
0.90
46
293
87
650
1.50
2.41
1.9
2.2
—
—
—
0
0
8
22
3.71
2.38
6.0
3.2
12.46
7.00
u/ml
—
8
22
64
450
1.55
2.33
3.4
2.0
2.87
2.59
mg/l
0.56
55
391
8
23
3.55
2.29
2.1
2.3
—
—
—
0
0
8
23
3.55
2.29
2.1
2.3
—
—
—
0
0
8
23
3.55
2.29
2.1
2.3
—
—
—
0
0
8
23
3.55
2.29
2.1
2.3
—
—
—
0
0
141
1169
1.43
2.23
6.4
4.2
6.61
6.29
mmol/l
0.68
130
1092
13
54
2.48
2.23
3.2
4.7
23.94
23.49
mmol/l
0.18
13
54
102
802
1.44
2.14
15.7
5.8
1.21
1.22
mmol/l
1.07
93
756
11
43
2.62
2.10
1.2
1.1
—
—
—
0
0
9
31
2.97
2.09
8.1
1.3
4.69
4.90
kpa
—
9
31
9
31
2.97
2.09
8.1
1.3
8.88
9.58
kpa
—
9
31
8
26
3.14
2.03
1.8
1.3
—
—
—
0
0
9
32
2.87
2.02
8.9
2.0
—
—
—
0
0
128
1058
1.40
1.99
10.0
6.5
0.71
0.70
%
0.08
123
1009
81
617
1.45
1.99
4.5
2.7
2.35
2.36
mmol/l
0.34
76
571
27
158
1.79
1.98
25.0
8.1
—
—
—
0
0
64
469
1.48
1.91
2.8
2.2
—
—
—
0
0
140
1184
1.38
1.86
9.6
6.2
2.02
2.07
e9/l
0.23
127
1056
14
66
2.18
1.85
2.1
1.3
144.60
130.59
au/ml
—
5
17
14
66
2.18
1.85
2.1
1.3
—
—
—
0
0
8
29
2.81
1.80
2.6
1.7
78.29
21.99
ng/l
—
8
29
26
155
1.75
1.80
4.5
4.9
0.25
0.46
%
—
8
39
116
957
1.37
1.77
3.2
2.4
—
—
estimate
—
0
0
6
18
3.38
1.75
1.0
1.1
—
—
—
0
0
66
496
1.44
1.73
2.8
2.3
358.80
325.36
umol/l
1.49
56
466
61
452
1.45
1.72
2.1
1.9
0.92
1.03
mg/l
0.13
44
336
20
112
1.85
1.70
3.9
2.7
64.73
69.68
e9/l
0.16
13
72
26
158
1.71
1.70
4.7
5.6
0.00
0.21
%
—
9
33
136
1157
1.35
1.69
9.7
6.2
0.04
0.04
e9/l
0.22
123
1006
136
1157
1.35
1.69
9.6
6.2
0.56
0.55
e9/l
0.13
123
1008
79
616
1.40
1.68
2.8
1.9
—
—
—
0
0
14
69
2.09
1.68
2.2
1.4
243.13
201.47
u/ml
—
8
38
21
120
1.81
1.68
22.4
6.1
24.28
24.05
mmol/l
0.18
21
120
251
2380
1.82
1.67
14.3
9.4
29.13
28.68
u/l
0.15
242
2345
26
159
1.70
1.66
4.4
4.9
0.25
0.08
%
—
8
38
25
152
1.71
1.63
3.1
2.4
14035.73
5979.58
u/l
0.26
12
66
5
14
3.62
1.62
1.6
1.4
—
—
—
0
0
136
1162
1.34
1.62
5.1
3.0
0.00
0.00
estimate
-0.00
32
224
10
43
2.38
1.60
1.1
1.2
—
—
—
0
0
91
732
1.37
1.60
1.7
1.5
—
—
—
0
0
6
20
3.04
1.59
2.5
3.4
—
—
—
0
0
78
613
1.38
1.58
2.4
2.4
53.25
65.06
u/l
0.87
68
584
34
227
1.57
1.56
5.4
1.9
2.56
2.46
g/l
0.62
34
211
6
21
2.90
1.51
4.0
2.5
—
—
—
0
0
68
526
1.39
1.51
4.9
3.3
7.40
7.40
ph
0.06
46
365
66
508
1.40
1.51
6.2
2.6
0.13
0.28
e6/l
1.36
51
351
136
1172
1.32
1.49
5.1
3.0
0.00
0.00
estimate
-0.00
32
218
33
222
1.55
1.47
1.5
1.6
—
—
—
0
0
138
1195
1.32
1.44
9.9
6.5
0.19
0.19
e9/l
0.24
126
1061
5
16
3.16
1.44
1.6
2.4
—
—
—
0
0
26
166
1.63
1.43
4.5
4.8
1.63
0.49
%
—
8
45
65
504
1.38
1.42
6.1
2.5
—
—
estimate
—
0
0
136
1183
1.30
1.35
5.2
3.0
0.09
0.00
estimate
0.49
32
206
9
42
2.18
1.35
1.1
1.3
—
—
—
0
0
105
891
1.29
1.23
15.4
6.1
1.21
1.22
mmol/l
0.96
86
780
21
134
1.62
1.18
2.0
1.4
—
—
—
0
0
15
89
1.73
1.10
1.3
1.2
—
—
—
0
0
7
32
2.22
1.09
4.1
3.2
92.66
91.61
%
—
7
32
7
33
2.15
1.06
2.1
2.3
—
—
—
0
0
38
283
1.40
1.06
2.1
1.8
—
—
—
0
0
18
114
1.62
1.05
29.9
6.0
—
—
—
0
0
18
114
1.62
1.05
1.6
1.8
—
—
—
0
0
105
908
1.26
1.02
4.6
2.7
0.00
0.01
estimate
0.50
32
188
48
374
1.34
1.02
1.7
1.6
—
—
—
0
0
73
604
1.29
1.02
6.0
2.7
11.98
43.86
e6/l
1.95
58
440
192
1781
1.27
1.00
5.2
4.3
14.70
14.44
pmol/l
0.77
176
1681
15
92
1.67
0.99
1.3
1.2
—
—
—
0
0
0
29
0.00
0.98
0.0
1.2
—
0.17
—
0
22
231
2199
1.36
0.96
20.1
10.6
3.94
3.94
mmol/l
0.03
225
2155
25
176
1.46
0.94
19.3
5.3
7.38
7.38
ph
0.01
13
100
199
2108
0.78
0.94
19.4
13.6
335.13
334.29
g/l
0.63
199
2098
6
27
2.25
0.94
1.7
1.4
—
—
—
0
0
142
1285
1.22
0.88
11.8
8.6
3.82
3.88
e9/l
0.11
131
1117
61
504
1.27
0.86
4.4
3.6
9.32
6.36
mg/mmol
0.24
41
339
107
943
1.22
0.85
2.1
1.8
1.50
1.45
mmol/l
0.21
93
863
108
953
1.22
0.85
4.6
2.7
6.06
6.18
ph
0.50
59
568
76
646
1.25
0.85
4.3
3.0
8.68
8.83
mmol/l
0.09
66
582
11
65
1.72
0.83
1.1
1.3
—
—
—
0
0
33
251
1.36
0.83
6.5
2.5
4.98
6.13
umol/l
0.38
28
220
13
81
1.64
0.83
2.2
2.4
2.24
5.22
iu/l
—
8
39
11
66
1.70
0.80
1.6
1.2
—
—
—
0
0
235
2257
1.33
0.79
17.5
10.3
20.96
19.55
mg/l
0.29
197
1762
19
132
1.47
0.78
1.2
1.2
—
—
—
0
0
12
75
1.63
0.76
1.7
1.2
—
—
—
0
0
60
503
1.25
0.76
3.5
3.1
87.17
38.87
mg/l
0.41
41
342
246
2381
1.39
0.75
20.1
12.0
73.66
70.94
umol/l
0.89
246
2356
5
24
2.10
0.75
4.6
3.2
14.00
19.46
u/ml
—
5
24
5
24
2.10
0.75
1.2
1.3
—
—
—
0
0
38
301
1.31
0.75
5.7
2.5
1.75
2.54
e6/l
0.28
20
144
78
677
1.21
0.71
1.4
1.4
0.52
1.28
u/ml
1.93
21
194
12
77
1.58
0.70
3.7
4.2
0.74
0.60
%
0.52
12
77
80
703
1.20
0.64
4.0
2.4
0.00
0.00
estimate
-0.00
30
178
47
391
1.24
0.64
4.2
2.7
113.96
67.23
ug/g
0.56
36
310
23
300
0.74
0.64
1.6
1.7
3.53
3.46
mmol/l
0.14
15
219
185
1749
1.18
0.61
4.6
3.2
40.03
42.01
u/l
0.24
175
1704
18
131
1.40
0.61
1.3
1.4
429.00
287.90
miu/ml
—
7
71
89
799
1.17
0.56
1.8
1.9
—
—
—
0
0
27
214
1.29
0.55
9.6
6.0
103.07
104.92
mmol/l
0.85
27
214
6
38
1.59
0.54
3.5
7.2
58.12
64.97
%
—
6
38
9
63
1.44
0.53
2.8
2.1
—
—
—
0
0
26
207
1.28
0.52
1.3
1.3
199.96
176.84
u/ml
0.07
12
87
82
737
1.16
0.50
7.4
3.3
27.42
123.02
e6/l
0.86
60
480
50
431
1.20
0.50
1.4
1.3
2.18
7.21
u/ml
1.80
21
179
33
396
0.81
0.50
1.3
1.4
—
—
—
0
0
7
45
1.57
0.49
1.6
1.2
—
—
—
0
0
66
586
1.17
0.47
4.8
4.1
—
—
—
0
0
121
1124
1.14
0.46
3.3
2.7
—
—
—
0
0
215
2082
1.16
0.42
5.9
5.0
1.71
1.79
mu/l
0.47
204
1989
11
79
1.41
0.41
1.0
1.1
5.21
4.89
u/ml
—
5
46
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
11.50
—
0
16
0
16
0.00
0.41
0.0
1.1
—
0.67
—
0
11
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
243
2378
1.23
0.40
16.0
9.1
—
—
—
0
0
68
614
1.14
0.39
1.6
1.3
2.22
2.15
g/l
0.11
45
396
84
770
1.13
0.39
1.7
1.8
98.02
96.29
pmol/l
0.11
45
411
6
41
1.47
0.36
1.0
1.1
—
—
—
0
0
47
416
1.16
0.36
1.7
1.9
—
—
—
0
0
41
465
0.86
0.35
2.1
1.6
—
—
—
0
0
6
43
1.40
0.35
1.0
1.0
—
—
—
0
0
16
127
1.28
0.34
3.4
3.3
7.38
7.35
ph
0.61
11
94
29
248
1.19
0.33
1.2
1.2
—
—
—
0
0
14
176
0.78
0.33
2.1
1.7
—
—
—
0
0
53
478
1.14
0.32
1.5
1.3
31.25
27.21
iu/ml
0.10
16
149
225
2200
1.14
0.30
4.8
4.3
4.64
4.76
mmol/l
1.24
212
2131
12
151
0.79
0.29
2.6
2.0
0.08
0.13
e6/l
0.22
12
142
32
363
0.87
0.28
1.8
2.4
0.64
0.63
ug/l
0.02
11
160
28
243
1.17
0.28
1.2
1.2
—
—
—
0
0
122
1161
1.09
0.28
3.9
2.8
93.71
92.81
ug/l
0.02
115
1121
52
474
1.12
0.27
1.7
1.5
19.79
20.84
nmol/l
0.22
47
430
23
197
1.18
0.27
1.6
1.4
34.26
24.56
iu/l
0.45
17
164
5
71
0.70
0.26
1.0
1.1
—
—
—
0
0
16
132
1.23
0.26
1.1
1.1
—
—
—
0
0
15
180
0.82
0.25
1.1
1.1
—
—
—
0
0
11
87
1.28
0.24
3.3
4.5
131.00
139.20
g/l
0.55
11
87
6
83
0.72
0.24
1.2
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
36.43
—
0
10
18
208
0.86
0.21
3.0
2.1
—
—
—
0
0
18
207
0.86
0.20
2.4
2.1
—
—
—
0
0
18
206
0.86
0.19
2.4
2.1
—
—
—
0
0
18
206
0.86
0.19
2.4
2.0
—
—
—
0
0
18
157
1.16
0.18
11.2
6.9
7.41
7.43
ph
—
7
86
29
263
1.12
0.17
1.2
1.2
—
—
—
0
0
224
2207
1.09
0.17
5.1
4.7
2.77
2.87
mmol/l
0.97
210
2128
11
92
1.20
0.16
1.0
1.1
1.14
5.18
u/ml
—
6
58
25
275
0.90
0.15
1.9
1.4
—
—
—
0
0
15
134
1.13
0.11
2.4
1.7
297.27
333.41
mu/l
0.19
15
123
204
2065
0.95
0.10
4.2
4.0
5.84
5.73
mmol/l
0.49
191
1954
56
537
1.05
0.10
5.1
2.8
1.02
1.02
kg/l
0.34
35
347
12
106
1.14
0.10
1.1
1.2
0.40
3.20
u/ml
—
5
61
5
62
0.80
0.08
3.0
2.8
23.00
24.66
mmol/l
—
5
62
10
88
1.14
0.08
2.3
2.7
—
—
—
0
0
7
64
1.10
0.08
1.0
1.2
—
—
—
0
0
7
67
1.05
0.08
5.1
7.7
—
—
—
0
0
6
74
0.81
0.07
1.7
1.9
—
—
—
0
0
6
74
0.81
0.07
1.0
1.1
—
—
—
0
0
6
74
0.81
0.07
1.0
1.1
—
—
—
0
0
14
153
0.91
0.07
1.0
1.1
1.48
1.53
g/l
0.28
14
153
15
163
0.92
0.07
1.1
1.2
—
—
—
0
0
15
138
1.09
0.06
2.9
3.0
—
—
—
0
0
18
192
0.93
0.05
2.4
2.2
—
—
—
0
0
256
2549
1.09
0.05
25.5
16.3
7.52
6.60
e9/l
0.68
249
2507
256
2549
1.09
0.05
25.5
16.2
4.60
4.65
e12/l
0.81
249
2510
67
656
1.03
0.04
8.6
5.5
—
—
—
0
0
218
2193
0.97
0.04
4.8
4.3
1.40
1.44
mmol/l
0.82
206
2117
200
2013
0.97
0.04
5.6
4.7
38.31
37.58
mmol/mol
0.50
189
1946
10
92
1.09
0.03
18.9
9.2
91.62
93.78
%
—
10
92
14
148
0.94
0.02
2.4
1.7
0.28
0.36
mg/l
—
8
74
14
148
0.94
0.02
1.0
1.1
—
0.59
—
0
11
27
262
1.03
0.02
1.2
1.4
—
—
—
0
0
10
94
1.07
0.01
18.4
9.0
1.67
1.43
%
—
10
94
33
324
1.02
0.00
2.0
3.0
772.50
233.93
ng/l
0.48
22
198
16
159
1.01
0.00
2.4
2.3
—
—
—
0
0
208
2079
1.00
0.00
4.1
3.7
1.41
1.31
mmol/l
0.94
195
1988
15
154
0.97
0.00
1.1
1.1
0.79
0.86
g/l
0.75
15
154
17
166
1.03
0.00
4.9
1.8
6.00
6.21
ph
0.49
12
97
57
566
1.01
0.00
2.7
3.3
1.11
1.37
ug/l
0.39
52
532
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
72
0.97
-0.00
1.9
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
10.46
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
9
91
0.99
-0.00
1.4
1.5
—
—
—
0
0
9
94
0.96
-0.00
1.4
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
188.24
—
0
7
9
89
1.01
-0.00
20.3
9.4
0.69
0.69
%
—
9
89
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
15.6
—
1.22
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
6.17
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
3.40
—
0
5
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.2
—
25.78
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_SCARLET_FEVER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_SCARLET_FEVER.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: AB1_SCARLET_FEVER – Scarlet fever

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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