Plasmodium falciparum malaria

AB1_MALARIA_FALCIPARIUM

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B50 Hospital discharge: ICD-9 — 084[0] Hospital discharge: ICD-8 — 084[0] Cause of death: ICD-10 — B50 Cause of death: ICD-9 — 084[0] Cause of death: ICD-8 — 084[0] 2 out of 7 registries used, show all original rules.	97
4. Check minimum number of events None	97
5. Include endpoints None	97
6. Filter based on genotype QC (FinnGen only)	80

Control definitions (FinnGen only)

Control exclude: AB1_PROTOZOAL

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF5

NAME	AB1_MALARIA_FALCIPARIUM
CONTROL_EXCLUDE	AB1_PROTOZOAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B50
HD_ICD_9	084[0]
HD_ICD_8	084[0]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B50
COD_ICD_9	084[0]
COD_ICD_8	084[0]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Plasmodium falciparum malaria based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1046	394	612
Only index persons	895	341	554
Unadjusted period prevalence (%)
Whole population	0.02	0.01	0.02
Only index persons	0.02	0.01	0.02
Median age at first event (years)
Whole population	38.27	38.30	38.54
Only index persons	37.53	36.68	38.05

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	80	46	34
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	38.03	34.74	42.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
90: Matched controls
900

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

B50.9

ICD-10 Finland

Plasmodium falciparum malaria, unspecified

+∞

65.9

0840A

ICD-9 Finland

Malaria, Falciparum malaria [malignant tertian]

+∞

17.2

08400

ICD-8 Finland

Falicparum malaria (malignant tertian)

+∞

8.5

B50.0

ICD-10 Finland

Plasmodium falciparum malaria with cerebral complications

+∞

8.5

B54

ICD-10 Finland

Unspecified malaria

+∞

7.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018095) Leukocytes [#/volume] in Urine

297

2.03

2.74

3.5

3.6

18.95

48.26

e6/l

1.05

207

(3021589) Normoblasts [#/volume] in Blood

347

1.82

2.05

10.3

11.9

0.00

0.01

e9/l

0.53

275

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.76

2.01

1.0

1.1

—

(42870588) Differential panel, method unspecified - Blood

252

1.80

1.89

6.8

5.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.36

1.88

1.9

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

167

1.88

1.87

2.3

2.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.28

1.63

1.6

1.7

—

(3025130) Human papilloma virus identified in Specimen

3.46

1.54

2.0

1.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.98

1.53

1.5

—

(3006315) Basophils [#/volume] in Blood

408

1.65

1.50

7.4

6.7

0.04

e9/l

0.33

348

(3019198) Lymphocytes [#/volume] in Blood

409

1.64

1.47

7.5

6.8

2.20

1.86

e9/l

0.51

364

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.93

1.47

2.2

1.7

—

(3002582) Erythrocytes [#/volume] in Urine

267

1.66

1.47

2.9

14.92

39.78

e6/l

1.31

204

(3022096) Basophils/Leukocytes in Blood

371

1.63

1.45

7.4

6.4

0.65

0.68

0.16

344

(3006504) Eosinophils/Leukocytes in Blood

373

1.61

1.41

7.4

6.3

2.06

2.93

2.21

349

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.88

1.39

1.8

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.72

1.39

2.5

1.9

—

(3019069) Monocytes/Leukocytes in Blood

374

1.61

1.39

7.5

6.3

8.89

8.46

0.51

352

(40758558) Short blood count panel - Blood

235

1.64

1.37

7.2

6.2

—

(3013115) Eosinophils [#/volume] in Blood

425

1.60

1.34

8.4

7.1

0.15

0.21

e9/l

2.07

374

(3002030) Lymphocytes/Leukocytes in Blood

377

1.59

1.32

7.5

6.3

29.83

27.76

0.45

359

(3019832) Treponema pallidum Ab [Presence] in Serum

1.88

1.32

1.9

1.8

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

109

1.81

1.31

2.2

1.9

—

(3001604) Monocytes [#/volume] in Blood

408

1.58

1.29

7.5

6.7

0.55

0.58

e9/l

0.34

352

(3013650) Neutrophils [#/volume] in Blood by Automated count

458

1.59

1.28

10.9

10.8

3.88

4.12

e9/l

0.37

399

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.17

1.27

1.5

1.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.50

1.26

3.7

2.2

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

662

1.80

1.24

19.0

18.0

13.77

13.53

0.89

655

(3015171) Extractable nuclear Ab [Units/volume] in Serum

0.00

1.19

0.0

1.2

—

(36660697) Celiac disease serology panel - Serum

1.94

1.15

1.0

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.80

1.12

1.8

1.7

—

(3014051) Protein [Presence] in Urine by Test strip

218

1.56

1.12

2.3

3.1

—

0.00

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

109

1.69

1.03

3.2

2.7

1.89

2.95

e6/l

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.96

1.01

1.3

1.4

24.01

22.29

iu/l

—

(3048689) Calprotectin [Mass/mass] in Stool

1.71

0.98

3.7

2.8

123.50

100.17

ug/g

—

(36304419) Bacteria [Presence] in Urine

220

1.47

0.87

3.0

2.7

—

estimate

—

(3030467) Casts [#/volume] in Urine by Automated count

232

1.44

0.81

3.0

2.8

0.33

0.26

e6/l

0.12

171

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.80

0.0

1.4

—

200.56

—

(3007853) Bacteria identified in Skin by Aerobe culture

100

1.60

0.79

1.4

1.7

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.24

0.77

1.2

1.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.24

0.77

1.6

2.3

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

144

1.50

0.76

2.8

45.79

256.89

ng/l

0.52

104

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.14

0.76

1.8

2.7

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.90

0.69

1.6

1.4

—

(3000494) Fungus identified in Specimen by Culture

104

1.53

0.68

1.3

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

317

1.34

0.64

2.0

93.11

98.81

pmol/l

0.40

165

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

740

1.55

0.63

15.9

14.0

84.58

84.56

ml/min/173m2

0.00

679

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

122

0.62

0.60

1.6

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

143

1.42

0.59

1.7

1.6

—

(40768443) Skin Pathology biopsy report

1.71

0.58

1.5

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

126

1.43

0.57

3.0

2.6

0.39

0.80

e6/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

594

1.34

0.55

8.9

8.5

73.19

76.18

u/l

0.33

562

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

533

1.31

0.54

3.2

3.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.53

0.52

2.0

1.2

—

(3003694) ABO and Rh group [Type] in Blood

220

1.32

0.52

1.6

1.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

326

1.29

0.51

2.2

1.9

1.26

1.38

mmol/l

0.41

272

(40768797) Stomach Pathology biopsy report

1.43

0.47

1.5

1.2

—

(3000492) Spirometry study

1.47

0.45

1.6

1.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

718

1.38

0.45

5.8

5.3

1.72

1.85

mu/l

0.47

668

(40768804) Tissue Pathology biopsy report

302

1.26

0.43

2.5

2.0

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

1.54

0.42

1.4

1.9

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.41

0.0

1.7

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.41

0.0

1.4

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

0.41

0.0

2.1

—

13.45

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.41

0.0

1.2

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.4

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.41

0.0

1.9

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.1

—

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

155.83

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3022313) Gas panel - Capillary blood

1.50

0.41

1.0

3.8

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

199

1.28

0.41

2.5

2.0

2.78

2.73

mg/l

0.02

177

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.40

0.0

1.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.45

0.40

1.2

1.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.45

0.40

1.2

1.1

—

(3026008) Bacteria identified in Urine by Culture

210

1.26

0.38

2.3

2.5

—

(3023368) Bacteria identified in Blood by Culture

220

1.26

0.37

4.1

4.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.60

0.37

1.4

7.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

360

1.20

0.32

3.7

7.4

1.22

1.21

mmol/l

0.81

318

(3004588) Protein electrophoresis panel - Serum or Plasma

1.32

0.31

2.0

2.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

575

1.19

0.27

2.9

3.1

45.78

43.26

u/l

0.07

540

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

0.70

0.27

2.4

1.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

143

1.23

0.25

1.6

1.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

597

1.18

0.25

5.0

4.5

14.16

14.74

pmol/l

1.30

556

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

738

0.82

0.25

5.8

4.7

6.18

5.89

mmol/l

0.53

686

(21494755) Public health laboratory ask at order entry panel

0.69

0.25

1.2

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

312

0.85

0.24

2.9

3.9

0.00

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

407

1.16

0.24

3.0

3.9

0.00

estimate

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

809

1.33

0.24

19.9

18.8

77.19

76.84

umol/l

0.05

801

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

372

0.86

0.23

3.1

2.8

—

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

408

1.15

0.23

3.0

4.0

0.00

estimate

—

(3019060) Gas panel - Arterial blood

1.23

0.22

1.2

5.1

—

(1002224) Polysomnography panel

1.20

0.22

1.0

1.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

186

0.83

0.22

6.3

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

(4062490) Immunoglobulin typing, IgG

0.00

0.21

0.0

1.1

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

79.30

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

2.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

0.16

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

725

1.21

0.21

4.2

4.0

1.22

1.29

mmol/l

0.43

673

(3025941) Bacteria identified in Stool by Culture

1.30

0.21

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.30

0.21

1.7

1.2

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

267.80

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.4

—

2.62

—

(40761511) CBC panel - Blood by Automated count

800

0.81

0.19

12.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

235

1.15

0.18

2.3

3.2

0.00

estimate

—

(1761868) Lipid panel - Serum or Plasma

346

0.88

0.17

4.8

2.9

—

(3013512) EKG study

244

0.87

0.17

4.0

3.3

—

(3032080) INR in Blood by Coagulation assay

335

1.12

0.16

18.1

10.8

1.43

1.18

inr

1.26

280

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

200

1.13

0.14

2.5

2.3

—

(3042936) Bacteria identified in Isolate by Culture

116

0.84

0.12

2.5

2.2

—

(3009261) Glucose [Presence] in Urine by Test strip

420

1.09

0.11

3.0

4.0

0.00

estimate

—

(3029937) Albumin [Presence] in Urine by Test strip

238

0.90

0.11

2.9

3.9

0.00

0.01

estimate

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

176

0.89

0.10

1.6

—

(3018418) pH of Serum or Plasma

233

1.10

0.10

2.8

4.0

7.40

7.39

0.61

171

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.17

0.10

1.0

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.09

0.10

1.6

5.7

24.30

25.33

mmol/l

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.14

0.09

1.0

2.7

2.45

5.98

ug/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

756

1.13

0.09

5.2

4.7

1.48

1.45

mmol/l

0.19

705

(3000963) Hemoglobin [Mass/volume] in Blood

839

1.24

0.08

24.2

23.0

134.71

136.31

g/l

0.49

831

(3026361) Erythrocytes [#/volume] in Blood

838

1.26

0.08

24.1

22.9

4.51

4.52

e12/l

0.07

825

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

838

1.26

0.08

24.1

23.2

40.57

40.72

0.13

830

(3010813) Leukocytes [#/volume] in Blood

838

1.26

0.08

24.1

23.0

6.76

e9/l

0.00

826

(3035941) MCH [Entitic mass]

838

1.26

0.08

24.0

22.9

30.14

30.33

0.37

832

(3015736) pH of Urine

324

1.08

0.08

2.8

3.4

6.19

0.01

180

(3024731) MCV [Entitic mean volume] in Red Blood Cells

837

1.28

0.08

24.0

22.9

90.30

90.98

0.55

831

(3007461) Platelets [#/volume] in Blood

837

1.28

0.08

24.2

23.0

246.36

253.70

e9/l

0.62

825

(40761536) Microorganisms panel - Urine sediment

1.08

0.08

3.3

3.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.88

0.07

1.4

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.88

0.07

1.4

1.8

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

780

1.10

0.05

16.1

16.5

139.72

139.73

mmol/l

0.01

768

(3014576) Chloride [Moles/volume] in Serum or Plasma

109

0.91

0.04

5.0

6.6

103.70

104.00

mmol/l

—

109

(3044640) Blood type and Crossmatch panel - Blood

270

0.95

0.04

2.6

2.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

161

1.07

0.03

1.9

1.4

1.85

2.28

g/l

—

100

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

772

1.08

0.03

15.1

15.2

22.99

23.08

mg/l

0.01

630

(3012516) Albumin [Mass/volume] in Urine

222

1.05

0.02

4.7

3.3

13.22

58.43

mg/l

2.78

152

(3020682) Albumin/Creatinine [Ratio] in Urine

228

0.95

0.02

6.2

3.9

2.41

11.46

mg/mmol

2.18

151

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

123

1.07

0.02

1.4

2.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

197

0.95

0.01

5.0

4.9

17.79

21.92

—

(3017732) Neutrophils [#/volume] in Blood

104

1.07

0.01

1.5

3.4

3.98

6.57

e9/l

0.58

(3009508) Creatinine [Moles/volume] in Urine

234

1.03

0.00

4.7

3.2

7.91

8.26

mmol/l

0.12

198

(3002256) Pathology report gross observation

107

1.03

0.00

1.5

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

295

0.97

0.00

3.4

3.7

93.35

39.75

ng/l

0.32

198

(4035726) Immunohistochemistry procedure

0.85

0.00

1.2

1.3

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

-0.00

0.0

1.2

—

9.60

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

-0.00

0.0

1.4

—

13.42

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.6

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.4

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.1

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

2.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.2

—

319.67

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.6

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

1.4

—

90.08

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.9

—

3.40

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

2.2

—

16.64

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.98

-0.00

2.0

3.9

64.83

82.73

ng/l

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

3.4

—

1.14

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.0

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

-0.00

0.0

1.6

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

263.33

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

3.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.87

-0.00

1.2

1.6

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

1.6

—

10.00

—

(3002032) Base excess in Venous blood by calculation

0.96

-0.00

1.3

3.4

1.31

1.69

mmol/l

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.7

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

14.16

—

(3022145) Colonoscopy Study observation

0.99

-0.00

1.6

1.3

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

6.3

—

(3022493) Free Hemoglobin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.0

—

76.80

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

95.00

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

130.20

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.3

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.7

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

7.5

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

4.40

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

9.4

—

63.14

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

121.98

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3000991) Gas panel - Venous blood

0.97

-0.00

1.7

7.1

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.6

—

8.26

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

2.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.6

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.5

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.6

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.7

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

3.0

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.2

—

63.94

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.7

—

0.60

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.0

—

9.16

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

10.8

—

1370.80

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_MALARIA_FALCIPARIUM and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1_MALARIA_FALCIPARIUM	2.699 [1.72, 4.25]	< 0.001
Birth year	0.99 [0.98, 1.0]	0.021

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 275 females with AB1_MALARIA_FALCIPARIUM died.

Males

Parameter	HR [95% CI]	p-value
AB1_MALARIA_FALCIPARIUM	1.672 [1.18, 2.38]	0.004
Birth year	0.989 [0.98, 1.0]	0.023

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 432 males with AB1_MALARIA_FALCIPARIUM died.

Mortality risk

Mortality risk for people of age

years, who have AB1_MALARIA_FALCIPARIUM.

N-year risk	Females	Males
1	0.279%	0.374%
5	1.305%	2.311%
10	3.095%	5.381%
15	5.829%	10.142%
20	10.234%	16.771%

Relationships between endpoints

↥

Index endpoint: AB1_MALARIA_FALCIPARIUM – Plasmodium falciparum malaria

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Plasmodium falciparum malaria

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints