Malaria

AB1_MALARIA

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters None 0 out of 7 registries used, show all original rules.	0
4. Check minimum number of events None	0
5. Include endpoints AB1_MALARIA_FALCIPARIUM AB1_MALARIA_VIVAX AB1_MALARIA_MALARIAE AB1_MALARIA_NOS	200
6. Filter based on genotype QC (FinnGen only)	171

Control definitions (FinnGen only)

Control exclude: AB1_PROTOZOAL

Extra metadata

First used in FinnGen datafreeze: DF5

NAME	AB1_MALARIA
CONTROL_EXCLUDE	AB1_PROTOZOAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	AB1_MALARIA_FALCIPARIUM\|AB1_MALARIA_VIVAX\|AB1_MALARIA_MALARIAE\|AB1_MALARIA_NOS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Malaria based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2110	834	1215
Only index persons	1820	733	1087
Unadjusted period prevalence (%)
Whole population	0.03	0.02	0.03
Only index persons	0.04	0.03	0.04
Median age at first event (years)
Whole population	35.94	35.12	36.67
Only index persons	35.61	34.39	36.42

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	171	86	85
Unadjusted period prevalence (%)	0.03	0.03	0.04
Median age at first event (years)	37.94	34.74	41.18

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
188: Matched controls
1880

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

B50.9

ICD-10 Finland

Plasmodium falciparum malaria, unspecified

+∞

60.8

B54

ICD-10 Finland

Unspecified malaria

+∞

59.6

0840A

ICD-9 Finland

Malaria, Falciparum malaria [malignant tertian]

+∞

16.9

B51.9

ICD-10 Finland

Plasmodium vivax malaria without complication

+∞

9.4

08410

ICD-8 Finland

Vivax malaria (benign tertian)

+∞

9.4

R50.9

ICD-10 Finland

Fever, unspecified

3.1

9.4

188

B50.0

ICD-10 Finland

Plasmodium falciparum malaria with cerebral complications

+∞

8.4

08400

ICD-8 Finland

Falicparum malaria (malignant tertian)

+∞

8.4

0846X

ICD-9 Finland

Malaria, unspecified

+∞

7.3

08499

ICD-8 Finland

Malaria, Unspecified forms

+∞

6.3

B53.0

ICD-10 Finland

Plasmodium ovale malaria

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018095) Leukocytes [#/volume] in Urine

621

1.98

5.04

4.2

3.8

17.69

119.51

e6/l

1.37

430

(3002582) Erythrocytes [#/volume] in Urine

545

1.89

4.34

3.5

3.1

11.61

50.22

e6/l

2.11

410

(36304419) Bacteria [Presence] in Urine

450

1.89

4.05

3.3

2.9

—

estimate

—

(42870588) Differential panel, method unspecified - Blood

526

1.83

3.84

8.9

6.3

—

(3030467) Casts [#/volume] in Urine by Automated count

468

1.83

3.75

3.4

3.0

0.29

0.49

e6/l

0.73

337

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

156

2.18

3.50

2.0

2.4

29.17

34.44

u/l

0.51

131

(21494815) CD4 cells/Lymphocytes in Specimen

6.01

3.05

2.1

2.6

34.24

38.77

—

(3000850) Epithelial cells [#/volume] in Urine

374

1.75

2.96

2.7

2.6

4.42

6.29

e6/l

0.33

345

(46235355) HIV 1 and 2 tests - Meaningful Use set

375

1.75

2.92

2.1

2.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

130

2.06

2.60

1.8

1.6

—

(3014037) CD3+CD4+ (T4 helper) cells/cells in Blood

4.50

2.50

2.1

3.3

—

42.18

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.72

2.41

2.0

1.6

—

(3021589) Normoblasts [#/volume] in Blood

747

1.55

2.29

13.6

11.6

0.00

e9/l

0.54

608

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

256

1.71

2.22

3.5

3.0

2.23

2.02

e6/l

0.07

114

(3007853) Bacteria identified in Skin by Aerobe culture

192

1.80

2.21

1.6

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

282

1.68

2.19

3.1

2.9

0.83

0.89

e6/l

0.05

140

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.78

2.17

1.4

1.3

—

(44806420) Estimation of glomerular filtration rate

4.39

2.17

2.3

1.8

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

4.39

2.17

2.5

2.1

—

(44790047) Parainfluenza type 1 nucleic acid detection

3.29

2.12

2.4

1.4

—

(44790049) Parainfluenza type 3 nucleic acid detection

3.29

2.12

2.4

1.4

—

(44790048) Parainfluenza type 2 nucleic acid detection

3.29

2.12

2.4

1.4

—

(44806118) Parainfluenza type 4 nucleic acid detection

3.29

2.12

2.4

1.4

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

586

1.53

2.11

4.3

3.1

27.80

30.26

u/l

0.68

558

(3003694) ABO and Rh group [Type] in Blood

459

1.56

2.09

1.7

1.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

3.59

2.07

2.3

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

205

1.74

2.04

2.2

1.7

—

(3000494) Fungus identified in Specimen by Culture

197

1.75

2.04

2.0

1.6

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

4.64

1.95

2.6

1.9

—

(3022096) Basophils/Leukocytes in Blood

767

1.48

1.91

9.1

6.6

0.64

0.68

0.26

720

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

380

1.55

1.87

3.2

2.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

3.61

1.85

1.2

1.9

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

3.61

1.85

1.2

1.9

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

3.61

1.85

2.5

1.9

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

3.61

1.85

1.2

1.9

—

(3006504) Eosinophils/Leukocytes in Blood

771

1.47

1.84

9.1

6.5

2.52

2.83

0.77

727

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.25

1.82

3.1

2.1

—

(3019069) Monocytes/Leukocytes in Blood

773

1.46

1.80

9.2

6.6

9.06

8.66

0.61

732

(40768804) Tissue Pathology biopsy report

612

1.47

1.78

2.9

2.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

205

1.68

1.77

2.2

2.1

—

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

111

1.90

1.77

1.7

2.9

68.00

65.62

ml/min/173m2

—

(3013115) Eosinophils [#/volume] in Blood

104

865

1.45

1.74

9.6

7.0

0.16

0.19

e9/l

1.59

762

(3019198) Lymphocytes [#/volume] in Blood

102

848

1.44

1.70

8.9

6.7

1.93

1.85

e9/l

0.19

755

(3006315) Basophils [#/volume] in Blood

101

839

1.44

1.68

8.9

6.6

0.04

e9/l

0.20

722

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

675

1.44

1.67

2.1

1.9

1.18

1.38

mmol/l

1.93

569

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.14

1.64

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

203

1.63

1.59

2.0

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

262

1.56

1.58

2.2

2.0

—

(3002030) Lymphocytes/Leukocytes in Blood

787

1.42

1.57

9.2

6.5

30.84

27.44

1.75

753

(3001604) Monocytes [#/volume] in Blood

100

837

1.42

1.56

8.9

6.6

0.54

0.57

e9/l

0.95

724

(3002256) Pathology report gross observation

198

1.61

1.49

1.5

1.3

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.87

1.49

4.5

3.3

5.01

5.18

kpa

0.48

(3026389) Candida sp identified in Specimen by Organism specific culture

3.18

1.44

1.6

1.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

225

1.57

1.44

2.8

2.2

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

286

1.51

1.42

5.3

3.4

0.84

0.82

mmol/l

0.47

274

(3025130) Human papilloma virus identified in Specimen

2.47

1.40

1.9

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

304

1.49

1.40

3.2

3.4

669.25

236.43

ng/l

0.43

220

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.66

1.38

1.8

1.5

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

2.66

1.38

1.8

2.9

33.00

33.04

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

203

1.57

1.35

1.5

1.9

1.50

1.49

0.04

178

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.14

1.30

2.5

1.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

109

944

1.37

1.30

13.5

10.3

3.58

4.14

e9/l

2.35

821

(3035637) Corticotropin [Mass/volume] in Plasma

2.82

1.29

1.6

1.7

40.40

39.28

ng/l

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.10

1.28

1.7

2.0

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

163

1517

1.56

1.26

20.0

14.5

82.64

84.25

ml/min/173m2

0.40

149

1397

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

392

1.41

1.25

2.7

2.0

3.17

2.75

mg/l

0.37

345

(40768443) Skin Pathology biopsy report

1.89

1.23

1.3

1.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

655

1.36

1.22

2.2

2.0

93.90

97.00

pmol/l

0.31

339

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

2.67

1.22

1.0

1.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

102

1.73

1.21

15.4

8.3

24.96

24.80

mmol/l

0.10

102

(3003327) Ova and parasites identified in Stool by Light microscopy

1.99

1.19

2.4

1.8

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.35

1.19

2.5

1.7

—

(3023368) Bacteria identified in Blood by Culture

450

1.38

1.19

5.0

4.5

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

135

1218

1.38

1.19

12.4

8.4

75.56

77.33

u/l

0.24

124

1163

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

690

1.33

1.13

2.8

2.6

77.22

73.94

nmol/l

0.47

630

(1616796) Gas panel - Central venous blood

2.38

1.13

2.6

2.2

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.79

1.12

4.1

3.5

0.94

1.59

mmol/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

453

0.70

1.11

3.9

3.0

684.29

1077.32

ng/l

1.02

367

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

121

1.63

1.10

2.9

2.0

—

(3010421) pH of Blood

1.99

1.10

2.0

3.2

7.38

7.42

—

(3044640) Blood type and Crossmatch panel - Blood

521

1.35

1.10

3.1

2.3

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

2.42

1.09

2.0

1.2

—

(3002179) Metamyelocytes/Leukocytes in Blood

146

1.57

1.09

5.1

5.0

0.69

0.54

0.16

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

293

1.42

1.08

1.5

1.7

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.97

1.08

1.1

1.2

—

(3000991) Gas panel - Venous blood

139

1.58

1.05

13.7

9.7

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

854

1.31

1.03

10.6

6.9

10.70

11.13

umol/l

0.27

816

(3023520) Reticulocytes [#/volume] in Blood

140

1.56

1.03

4.2

2.8

89.05

71.67

e9/l

0.57

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.92

1.02

2.1

2.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

200

1.47

1.01

2.0

1.8

—

(21494755) Public health laboratory ask at order entry panel

197

0.58

1.00

1.5

1.4

—

(4035726) Immunohistochemistry procedure

133

1.56

0.99

1.5

1.4

—

(40758558) Short blood count panel - Blood

491

1.33

0.98

8.6

5.9

—

(4268621) Lupus anticoagulant assay

2.20

0.98

2.4

2.1

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

760

1.30

0.98

3.7

3.1

122.70

116.49

ug/l

0.11

719

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

194

1.46

0.95

2.2

1.9

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.93

0.95

1.4

1.2

—

(3021440) Promyelocytes/Leukocytes in Blood

143

1.53

0.95

6.0

5.2

0.25

0.21

0.08

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.18

0.92

1.2

1.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.18

0.92

1.2

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

103

1.60

0.91

2.7

2.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

179

1.46

0.90

1.7

—

(3027315) Oxygen [Partial pressure] in Blood

2.03

0.87

2.2

7.95

8.96

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.03

0.87

2.2

4.95

4.91

kpa

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.64

0.87

2.1

3.4

24.81

24.32

mmol/l

0.25

(3011288) Drugs identified in Urine by Screen method Nominal

1.85

0.87

1.3

1.9

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.97

0.85

2.2

1.4

—

(3028707) Methadone [Presence] in Urine by Screen method

1.97

0.85

1.3

1.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

165

1567

1.43

0.84

5.1

4.9

4.62

4.64

mmol/l

0.11

157

1469

(3048689) Calprotectin [Mass/mass] in Stool

209

1.40

0.82

4.1

2.5

137.78

94.33

ug/g

0.58

170

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

117

1066

1.26

0.78

3.5

3.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

1.79

0.77

1.2

1.1

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

132

0.59

0.77

1.9

1.4

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.76

0.0

1.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

228

0.67

0.75

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.87

0.74

1.4

1.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.64

0.73

1.3

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

2.03

0.73

10.8

3.2

44.62

17.02

u/ml

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.61

0.72

1.1

1.3

—

(4195642) Thrombophilia screening test

1.95

0.71

1.2

—

(3044290) Cell count panel - Cerebral spinal fluid

1.95

0.71

1.0

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.53

0.69

1.9

1.8

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

155

1470

1.31

0.68

6.6

5.9

38.45

39.02

mmol/mol

0.35

148

1395

(3000963) Hemoglobin [Mass/volume] in Blood

177

1714

1.56

0.68

29.7

23.1

134.59

136.56

g/l

0.98

177

1697

(3035933) Granulocytes/Leukocytes in Blood

1.65

0.67

3.6

2.7

59.43

61.58

—

(3017181) Myelocytes/Leukocytes in Blood

155

1.40

0.66

6.0

5.0

0.75

0.93

0.13

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

124

1149

1.23

0.65

3.5

3.3

45.77

47.06

u/l

0.07

113

1090

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

165

1582

1.35

0.64

5.5

2.74

2.73

mmol/l

0.04

158

1477

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

163

1561

1.33

0.63

5.0

4.8

1.45

mmol/l

0.07

152

1456

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

761

1.21

0.62

9.8

8.0

1.22

1.21

mmol/l

0.42

663

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

0.60

0.0

2.3

—

13.47

—

(3011648) Oxygen content in Venous blood

0.00

0.60

0.0

1.7

—

11.17

—

(3022313) Gas panel - Capillary blood

1.59

0.60

4.5

3.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

381

0.78

0.59

1.9

1.4

2.51

2.50

g/l

0.01

225

(40768800) Prostate Pathology biopsy report

1.74

0.58

1.0

1.2

—

(3014051) Protein [Presence] in Urine by Test strip

465

1.23

0.58

2.6

3.0

—

0.15

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

746

1.20

0.58

3.8

2.8

—

estimate

—

(3019309) Folate [Moles/volume] in Red Blood Cells

223

1.30

0.56

1.7

1025.43

1272.99

nmol/l

0.86

171

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.52

0.55

2.1

1.5

92.11

96.10

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

1.60

0.55

2.0

2.2

143.33

124.04

g/l

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

1.60

0.55

1.2

—

(4024509) Urine culture

1.50

0.54

1.6

1.9

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

198

1.30

0.53

2.5

3.0

8.70

8.07

umol/l

0.07

173

(40768793) Breast Pathology biopsy report

1.52

0.52

1.5

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

151

1444

1.23

0.50

5.5

5.2

1.78

1.86

mu/l

0.35

140

1339

(3018418) pH of Serum or Plasma

492

1.20

0.49

6.3

3.9

7.40

7.39

0.28

346

(3042936) Bacteria identified in Isolate by Culture

238

1.26

0.48

2.7

2.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

343

1.21

0.45

3.0

3.2

0.68

0.76

ug/l

0.44

207

(3026493) Urate [Moles/volume] in Serum or Plasma

410

1.20

0.44

3.5

2.8

344.44

348.36

umol/l

0.09

367

(3012544) pH of Venous blood

158

1.30

0.44

2.9

3.7

7.39

7.38

—

(3032080) INR in Blood by Coagulation assay

702

1.16

0.43

15.9

10.8

1.27

1.18

inr

0.66

589

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

646

0.85

0.43

3.8

3.5

0.00

0.02

estimate

0.50

158

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

1.42

0.42

1.6

1.9

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

1.58

0.42

1.2

—

1.60

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

155

1494

1.21

0.42

4.2

1.22

1.31

mmol/l

1.13

143

1385

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.37

0.41

3.0

3.1

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.41

0.0

1.3

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

299

1.21

0.41

2.3

1.7

511.67

44656957.15

pmol/l

0.50

262

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.41

0.0

1.2

—

(3025159) Blasts/Leukocytes in Blood

143

1.29

0.38

7.2

5.7

0.22

0.25

—

(3004588) Protein electrophoresis panel - Serum or Plasma

107

1.33

0.38

6.4

2.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.34

0.36

1.5

1.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.41

0.35

1.5

1.4

—

(1002224) Polysomnography panel

100

1.32

0.34

1.0

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

162

1576

1.20

0.33

20.4

15.3

26.79

24.02

mg/l

0.41

131

1305

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.31

0.33

1.2

1.3

—

(3019150) Specific gravity of Urine by Refractometry

356

0.85

0.33

2.8

3.8

1.02

kg/l

0.27

230

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.29

0.32

1.0

1.2

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

1.29

0.32

1.3

1.4

—

3.38

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

1.29

0.32

1.3

1.4

—

2.30

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

281

0.83

0.31

1.4

1.3

0.92

8.46

u/ml

—

112

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

129

1.26

0.31

1.6

1.5

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

121

1.26

0.29

3.2

4.2

98.53

84.19

ng/l

0.17

107

(3015736) pH of Urine

680

1.12

0.28

3.3

6.22

6.15

0.20

383

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

150

0.79

0.28

4.7

6.8

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

565

1.12

0.26

5.4

5.3

2.45

2.47

ug/l

0.01

508

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.23

0.25

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

336

0.87

0.24

1.6

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.29

0.23

3.0

1.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.20

0.21

1.0

1.7

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.21

0.0

1.0

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

251.18

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

109.54

—

(3017704) Immunofixation for Urine

0.00

0.21

0.0

2.5

—

(4027681) Cerebrospinal fluid IgG ratio and IgG index

0.00

0.21

0.0

1.3

—

0.47

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.21

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

3.2

—

1.10

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.21

0.0

1.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

164

1.18

0.21

4.2

3.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3004451) EKG impression Narrative

0.00

0.21

0.0

1.3

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3028308) Erythrocytes [#/volume] in Pleural fluid

0.00

0.21

0.0

1.5

—

3234.00

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

0.21

0.0

1.2

—

11.38

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.2

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

77.31

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

1.26

0.20

1.3

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

445

1.11

0.20

4.4

4.6

20.06

21.50

0.32

206

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.20

0.0

2.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.21

0.20

1.3

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

871

1.09

0.19

3.9

3.7

0.00

estimate

-0.00

174

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.16

0.19

1.2

1.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.25

0.19

2.3

1.2

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.14

0.19

1.0

1.4

—

(3019977) pH of Arterial blood

166

1.16

0.19

16.1

11.7

7.44

7.41

—

(3009508) Creatinine [Moles/volume] in Urine

516

1.09

0.18

4.5

3.3

7.47

8.08

mmol/l

0.46

439

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

1.13

0.17

1.7

1.6

26.91

4.62

mg/l

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.12

0.17

1.0

1.1

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.74

0.17

2.4

10.5

1.64

1.51

—

(3000492) Spirometry study

187

1.14

0.16

1.6

1.5

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

216

1.13

0.16

16.8

7.4

104.42

104.16

mmol/l

0.13

216

(3035350) Ketones [Presence] in Urine by Test strip

856

1.08

0.16

3.9

3.7

0.00

estimate

-0.00

186

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

306

0.90

0.16

1.4

1.3

38.03

30.42

iu/ml

—

(3019060) Gas panel - Arterial blood

1.22

0.16

5.4

10.0

—

(3027944) Amphetamines [Presence] in Urine

0.74

0.15

1.2

1.4

—

(40761536) Microorganisms panel - Urine sediment

131

1.16

0.15

6.6

3.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.79

0.15

1.0

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

170

1.13

0.14

16.1

11.4

4.98

5.05

kpa

0.11

165

(3027801) Oxygen [Partial pressure] in Arterial blood

170

1.13

0.14

16.1

11.4

13.03

12.79

kpa

0.07

165

(3029937) Albumin [Presence] in Urine by Test strip

473

1.08

0.14

4.1

3.7

0.00

0.02

estimate

0.74

168

(3021601) Nitrite [Presence] in Urine by Test strip

851

1.06

0.13

3.9

3.7

0.00

estimate

-0.00

188

(1761868) Lipid panel - Serum or Plasma

716

0.94

0.11

3.9

3.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

595

1.06

0.11

3.7

3.6

51.33

35.02

ng/l

0.23

407

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

218

0.91

0.10

1.3

2.1

3.44

3.54

ratio

0.14

180

(36660697) Celiac disease serology panel - Serum

154

1.11

0.10

1.1

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.14

0.10

1.6

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.14

0.10

1.6

1.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

176

0.90

0.10

4.8

4.5

34.33

31.82

—

116

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.11

0.10

1.6

1.2

—

(4094501) Cardiovascular stress test using bicycle ergometer

1.11

0.10

1.2

1.1

—

(3022145) Colonoscopy Study observation

196

0.91

0.09

1.7

1.4

—

(3012516) Albumin [Mass/volume] in Urine

480

1.06

0.09

4.8

3.4

94.87

64.82

mg/l

0.22

329

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.09

0.09

1.3

1.4

—

(3037522) Nuclear Ab [Titer] in Serum

224

1.08

0.09

1.4

448.00

434.91

titre

—

(3022621) pH of Urine by Test strip

144

0.90

0.08

1.7

2.0

6.56

6.19

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.05

0.08

1.5

1.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

122

1200

1.05

0.08

4.9

4.4

14.49

14.75

pmol/l

0.57

108

1113

(3016879) Cocaine [Presence] in Urine

0.84

0.08

1.5

1.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

1.07

0.07

1.3

1.1

1.00

0.89

g/l

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.04

0.07

2.9

2.4

0.68

0.62

—

(40760892) CBC W Ordered Manual Differential panel - Blood

397

1.04

0.05

5.7

5.3

—

(3025941) Bacteria identified in Stool by Culture

1.09

0.03

1.1

1.2

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

121

1200

1.02

0.02

4.7

4.1

10.29

10.81

mm/h

0.18

115

1122

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

252

1.04

0.02

1.5

1.4

—

(3026008) Bacteria identified in Urine by Culture

452

1.02

0.01

3.0

2.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

493

1.02

0.01

6.5

4.0

17.21

11.31

mg/mmol

0.21

329

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

114

0.96

0.00

1.5

2.4

11.11

9.03

ug/l

0.15

104

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

150

1504

0.99

0.00

5.4

4.7

6.02

5.92

mmol/l

0.30

139

1389

(40768797) Stomach Pathology biopsy report

217

1.02

0.00

1.4

1.3

—

(40761511) CBC panel - Blood by Automated count

163

1633

0.99

0.00

15.5

13.0

—

(3013512) EKG study

495

1.01

0.00

3.6

3.4

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.4

—

24.11

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

9.89

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.8

—

8.60

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.7

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.3

—

(3044007) Cell count panel - Peritoneal fluid

0.00

-0.00

0.0

1.3

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.5

—

11.30

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

94.50

—

(3041096) Erythrocytes [Presence] in Urine by Automated

490

1.00

-0.00

3.5

3.0

0.00

estimate

-0.00

151

(3000764) Benzodiazepines [Presence] in Urine

0.92

-0.00

1.4

—

(3028300) Cannabinoids [Presence] in Urine

0.88

-0.00

1.4

—

(4133840) Spirometry

0.00

-0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.96

-0.00

1.3

1.1

1.52

1.58

g/l

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

390

1.00

-0.00

3.5

3.7

—

0.33

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3027008) Opiates [Presence] in Urine

0.89

-0.00

1.4

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.6

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.01

-0.00

2.9

2.3

1.09

1.26

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.5

—

4.62

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.02

-0.00

3.0

1.4

—

(3022689) Creatine [Moles/volume] in Urine

0.00

-0.00

0.0

1.4

—

12.82

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.2

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3006441) Cardiolipin IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

2.0

—

(3013727) Leukocytes other/Leukocytes in Blood

0.00

-0.00

0.0

4.6

—

52.00

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

-0.00

0.0

1.4

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

2.2

—

0.88

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_MALARIA and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1_MALARIA	2.107 [1.54, 2.88]	< 0.001
Birth year	1.002 [0.99, 1.01]	0.702

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 611 females with AB1_MALARIA died.

Males

Parameter	HR [95% CI]	p-value
AB1_MALARIA	1.356 [1.05, 1.74]	0.018
Birth year	0.987 [0.98, 1.0]	0.007

During the follow-up period (1.1.1998 — 31.12.2019), 85 out of 823 males with AB1_MALARIA died.

Mortality risk

Mortality risk for people of age

years, who have AB1_MALARIA.

N-year risk	Females	Males
1	0.239%	0.241%
5	1.427%	1.494%
10	3.723%	3.803%
15	7.009%	7.091%
20	12.556%	12.263%

Relationships between endpoints

↥

Index endpoint: AB1_MALARIA – Malaria

GWS hits: 2

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Malaria

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints