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Early syphilis, including avohilmo

Endpoint Browser PheWeb

AB1_EARLY_SYPHILIS_WIDE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — A51
  • Hospital discharge: ICD-10 — A51
  • Hospital discharge: ICD-9 — 09[1]
  • Hospital discharge: ICD-8 — 09[1]
  • Cause of death: ICD-10 — A51
  • Cause of death: ICD-9 — 09[1]
  • Cause of death: ICD-8 — 09[1]

3 out of 7 registries used, show all original rules.

527

4. Check minimum number of events

None

527

5. Include endpoints

None

527

6. Filter based on genotype QC (FinnGen only)

482

Control definitions (FinnGen only)

Control exclude
AB1_SEXUAL_TRANSMISSION

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF13

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 482 156 326
Unadjusted period prevalence (%) 0.12 0.06 0.15
Median age at first event (years) 38.18 30.03 42.08

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
527
Matched controls
5270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
22.9
269.8
239
184
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
134.9
230.2
116
11
A51.3
ICD-10 Finland
Secondary syphilis of skin and mucous membranes
+∞
224.5
199
*
A51.0
ICD-10 Finland
Primary genital syphilis
+∞
209.8
187
*
WW200
NOMESCO Finland
Immunization
27.4
157.3
113
52
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
45.0
153.5
93
25
A63.0
ICD-10 Finland
Anogenital (venereal) warts
38.7
147.3
93
29
A56.3
ICD-10 Finland
Chlamydial infection of anus and rectum
1432.5
120.8
113
*
A54.6
ICD-10 Finland
Gonococcal infection of anus and rectum
+∞
101.4
94
*
A51.9
ICD-10 Finland
Early syphilis, unspecified
+∞
89.1
83
*
Y25
ICPC
Fear sexually transm disease male
10.2
89.0
112
136
A54.5
ICD-10 Finland
Gonococcal pharyngitis
966.5
86.1
82
*
A54.0
ICD-10 Finland
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
+∞
70.4
66
*
Z29.2
ICD-10 Finland
Other prophylactic chemotherapy
132.6
56.1
59
5
Z21
ICD-10 Finland
Asymptomatic human immunodeficiency virus [HIV] infection status
200.1
53.0
54
*
A53.9
ICD-10 Finland
Syphilis, unspecified
+∞
51.9
49
*
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
76.5
49.1
55
8
D06BB04
ATC
podophyllotoxin; topical
6.8
48.7
83
140
A60.0
ICD-10 Finland
Herpesviral infection of genitalia and urogenital tract
16.3
43.8
38
25
09100
ICD-8 Finland
Early syphilis, symptomatic, Primary syphilis, except extragenital chancre
+∞
43.3
41
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.5
32.0
89
230
A51.5
ICD-10 Finland
Early syphilis, latent
+∞
26.3
25
*
Z20.2
ICD-10 Finland
Contact with and exposure to infections with a predominantly sexual mode of transmission
6.6
25.3
42
68
Y70
ICPC
Syphilis male
+∞
25.2
24
*
A56.4
ICD-10 Finland
Chlamydial infection of pharynx
136.5
24.8
26
*
Z3231
NOMESCO Finland
Registered nurse
2.7
24.4
177
822
0913A
ICD-9 Finland
Early syphilis, symptomatic, Secondary syphilis of skin or mucous membranes
+∞
24.1
23
*
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
4.9
23.2
54
120
Y71
ICPC
Gonorrhoea male
+∞
23.1
22
*
Z2221
NOMESCO Finland
Medical doctor
2.7
22.9
168
781
09120
ICD-8 Finland
Early syphilis, symptomatic, Secondary syphilis of skin and mucous membranes
+∞
21.0
20
*
ULA02
NOMESCO Finland
Kolposcopy
4.4
20.9
55
135
Z25.1
ICD-10 Finland
Need for immunization against influenza
4.6
19.9
49
114
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
109.2
19.7
21
*
A51.4
ICD-10 Finland
Other secondary syphilis
+∞
17.8
17
*
B23.0
ICD-10 Finland
Acute HIV infection syndrome
+∞
16.8
16
*
J05AB11
ATC
valaciclovir; oral
2.7
15.7
101
432
A55
ICD-10 Finland
Chlamydial lymphogranuloma (venereum)
+∞
15.7
15
*
J01MA02
ATC
ciprofloxacin; systemic
2.1
15.4
211
1252
ZX114
NOMESCO Finland
Intramuscular
11.8
15.4
28
25
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
6.9
15.4
24
36
EB1AA, ,
SPAT
3.6
15.4
53
158
D06BB10
ATC
imiquimod; topical
4.3
15.0
40
99
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
4.5
14.5
36
84
D11
ICPC
Diarrhoea
2.6
14.1
94
408
Y99
ICPC
Genital disease male other
20.7
13.9
20
10
J05AB01
ATC
aciclovir; systemic
2.3
13.1
122
615
TAB00
NOMESCO Finland
Lumbar puncture
3.7
13.1
42
119
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.1
12.5
167
969
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
12.0
12.4
22
19
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
12.2
127
668
WX110, ,
SPAT
3.3
11.7
45
144
A52.1
ICD-10 Finland
Symptomatic neurosyphilis
+∞
11.5
11
*
A52.9
ICD-10 Finland
Late syphilis, unspecified
+∞
11.5
11
*
WNF00
NOMESCO Finland
Infection source and contact determination
35.9
11.3
14
*
Z71.8
ICD-10 Finland
Other specified counselling
1.9
11.3
199
1263
Z76.0
ICD-10 Finland
Issue of repeat prescription
2.0
10.8
163
978
WX290, ,
SPAT
4.0
10.8
31
81
J01AA02
ATC
doxycycline; systemic
2.0
10.8
390
3102
EB1SA, ,
SPAT
3.3
10.5
41
132
A54.9
ICD-10 Finland
Gonococcal infection, unspecified
+∞
10.4
10
*
J01DB01
ATC
cefalexin; oral
2.2
9.7
445
3763
J01FA10
ATC
azithromycin; systemic
1.8
9.6
316
2396
A97
ICPC
No disease
2.0
9.5
115
637
A56.2
ICD-10 Finland
Chlamydial infection of genitourinary tract, unspecified
30.6
9.4
12
*
Z20.6
ICD-10 Finland
Contact with and exposure to human immunodeficiency virus [HIV]
22.2
9.4
13
6
I84
ICD-10 Finland
Hemorrhoids
4.7
9.1
21
46
D06AX01
ATC
fusidic acid; topical
2.4
9.0
64
285
N48.1
ICD-10 Finland
Balanoposthitis
3.4
8.9
33
103
LEB00
NOMESCO Finland
Biopsy of vagina
8.7
8.4
17
20
0910A
ICD-9 Finland
Early syphilis, symptomatic, Genital syphilis (primary)
+∞
8.4
8
*
A53.0
ICD-10 Finland
Latent syphilis, unspecified as early or late
+∞
8.4
8
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.9
8.3
114
656
U07
ICPC
Urine symptom/complaint other
2.8
8.3
43
164
N05BA04
ATC
oxazepam; oral
1.9
8.2
132
800
N06AX11
ATC
mirtazapine; oral
1.7
8.1
183
1229
P01AB01
ATC
metronidazole; oral, rectal
1.7
7.9
187
1270
S29
ICPC
Skin symptom/complaint other
1.9
7.7
103
586
F43.29
ICD-10 Finland
Adaptation disorder UNS
3.9
7.6
22
58
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
2.5
7.4
49
211
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
1.8
7.4
125
768
A03.3
ICD-10 Finland
Shigellosis due to Shigella sonnei
+∞
7.3
7
*
A51.1
ICD-10 Finland
Primary anal syphilis
+∞
7.3
7
*
A03.1
ICD-10 Finland
Shigellosis due to Shigella flexneri
+∞
7.3
7
*
B17.1
ICD-10 Finland
Acute hepatitis C
20.3
7.2
10
5
R74
ICPC
Upper respiratory infection acute
1.7
7.0
196
1384
Z01.7
ICD-10 Finland
Laboratory examination
1.9
6.7
94
542
R4120
NOMESCO Finland
Occupational therapy
2.6
6.6
37
147
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.0
6.6
71
375
D01BA02
ATC
terbinafine; oral
1.7
6.4
136
889
N48.8
ICD-10 Finland
Other specified disorders of penis
8.3
6.4
13
16
N05CF01
ATC
zopiclone; oral
1.7
6.3
144
958
A52.8
ICD-10 Finland
Late syphilis, latent
+∞
6.3
6
*
A51.2
ICD-10 Finland
Primary syphilis of other sites
+∞
6.3
6
*
A52.3
ICD-10 Finland
Neurosyphilis, unspecified
+∞
6.3
6
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.3
6.2
46
209
EMB10
NOMESCO Finland
Tonsillectomy
2.4
6.1
40
171
B18.2
ICD-10 Finland
Chronic viral hepatitis C
4.2
6.1
16
39
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.8
6.1
31
117
B37.4
ICD-10 Finland
Candidiasis of other urogenital sites
12.7
6.1
10
8
D19
ICPC
Teeth/gum symptom/complaint
1.6
6.1
170
1191
F52.2
ICD-10 Finland
Failure of genital response
3.1
6.0
25
84

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Chlamydial infection of anus and rectum
A56.3 (45542533)
Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture
698-1 (3028334)
Gonococcal pharyngitis
A54.5 (45600426)
HIV disease resulting in other specified conditions
B23.8 (45561749)
Asymptomatic human immunodeficiency virus [HIV] infection status
Z21 (45566407)
Gonococcal infection of anus and rectum
A54.6 (45581125)
Secondary syphilis of skin and mucous membranes
A51.3 (45537730)
Other secondary syphilis
A51.4 (45552185)
Primary genital syphilis
A51.0 (45566511)
Other prophylactic chemotherapy
Z29.2 (45600313)
Early syphilis, unspecified
A51.9 (45600417)
Syphilis, unspecified
A53.9 (45600422)
Treponema pallidum Ab [Titer] in Serum by Hemagglutination
26009-1 (3019539)
Reagin Ab [Titer] in Serum by VDRL
50690-7 (3029634)
Venereal disease screening
171128005 (4064905)
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
A54.0 (45547416)
Unspecified human immunodeficiency virus [HIV] disease
B24 (45547443)
Early syphilis, latent
A51.5 (45571434)
tenofovir disoproxil and emtricitabine
J05AR03 (21603183)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
HIV disease resulting in (persistent) generalized lymphadenopathy
B23.1 (45532868)
Chlamydial infection of lower genitourinary tract
A56.0 (45585926)
Anogenital (venereal) warts
A63.0 (45585929)
Early syphilis, symptomatic, Secondary syphilis of skin or mucous membranes
0913A (2000400743)
Kolposcopy
ULA02 (2001306679)
Intramuscular
ZX114 (2001311493)
Medical doctor
Z2221 (2001311556)
SMOKING - SMOKE2: no - SMOKE3: former - SMOKE5: Unspecified
SMOKING-2-2-0 (2002330110)
SMOKING - SMOKE2: no - SMOKE3: never - SMOKE5: Unspecified
SMOKING-2-3-0 (2002330113)
SMOKING - SMOKE2: yes - SMOKE3: current - SMOKE5: Unspecified
SMOKING-1-1-0 (2002330116)
podophyllotoxin
D06BB04 (21602086)
Hepatitis C virus Ab [Presence] in Serum
16128-1 (3017143)
Treponema pallidum Ab [Presence] in Serum
22587-0 (3019832)
Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection
20444-6 (3028369)
Protein [Mass/volume] in Urine
2888-6 (3037121)
Infectious Disease
44 (38004484)
Inpatient Visit
IP (9201)
Clinical & Laboratory Dermatological Immunology Physician
207NI0002X (38003841)
HIV 1 and 2 tests - Meaningful Use set
75622-1 (46235355)
Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
6357-8 (3024950)
Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
21416-3 (3003510)
Hepatitis B virus core Ab [Presence] in Serum
16933-4 (3021879)
Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
24111-7 (3011371)
Emergency Room Visit
ER (9203)
Phosphate [Moles/volume] in Serum or Plasma
14879-1 (3003458)
Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
21613-5 (3006093)
Fear sexually transm disease male
Y25 (2002001393)
Outpatient Visit
OP (9202)
Treatment of a patient needing special arrangements
WYA30 (2001310874)
Supplier / Service Provider
OMOP5117446 (33004)
Abnormal findings in specimens from female genital organs, abnormal cytological findings
R87.6 (45558487)
sildenafil; oral
G04BE03 (21602648)
Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1920-8 (3013721)
Differential panel, method unspecified - Blood
69738-3 (42870588)
Short blood count panel - Blood
55429-5 (40758558)
Bilirubin.total [Moles/volume] in Serum or Plasma
14631-6 (3006140)
Hemoglobin [Presence] in Urine by Test strip
5794-3 (3011397)
Basophils/Leukocytes in Blood
30180-4 (3022096)
Eosinophils/Leukocytes in Blood
26450-7 (3006504)
Laboratory Visit
OMOP4822461 (32036)
Monocytes/Leukocytes in Blood
26485-3 (3019069)
Neutrophils/Leukocytes in Blood
26511-6 (3018010)
Lymphocytes/Leukocytes in Blood
26478-8 (3002030)
CD3+CD4+ (T4 helper) cells/cells in Blood
8123-2 (3014037)
Leukocytes [#/volume] in Urine
30405-5 (3018095)
Monocytes [#/volume] in Blood
26484-6 (3001604)
Basophils [#/volume] in Blood
26444-0 (3006315)
Lymphocytes [#/volume] in Blood
26474-7 (3019198)
Urinalysis macro (dipstick) panel - Urine
24357-6 (3037467)
Hepatitis B virus surface Ag [Presence] in Serum
5195-3 (3019284)
Eosinophils [#/volume] in Blood
26449-9 (3013115)
Neutrophils [#/volume] in Blood by Automated count
751-8 (3013650)
Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
1805-1 (3016417)
Protein [Presence] in Urine by Test strip
20454-5 (3014051)
Normoblasts [#/volume] in Blood
715-3 (3021589)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
Case Management Agency
251B00000X (38004193)
MCHC [Entitic Mass/volume] in Red Blood Cells
28540-3 (3003338)
Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
6768-6 (3035995)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
Pharmacy visit
OMOP4822462 (581458)
Albumin [Mass/volume] in Serum or Plasma
1751-7 (3024561)
Prothrombin time (PT) actual/Normal
5894-1 (3033658)
Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M
62238-1 (40764999)
Platelets [#/volume] in Blood
26515-7 (3007461)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
MCH [Entitic mass]
28539-5 (3035941)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
cefalexin; oral
J01DB01 (21602870)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
Glucose [Moles/volume] in Serum or Plasma
14749-6 (3013826)
Telehealth
OMOP5556618 (722455)
ciprofloxacin; oral, parenteral
J01MA02 (21603009)
Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1742-6 (3006923)
CD3+CD4+ (T4 helper) cells [#/volume] in Blood
24467-3 (3028167)
Immunization
WW200 (2001310599)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
262
87
58.90
307.65
13.2
1.8
9.96
—
titre
—
134
0
177
147
17.62
187.29
6.4
3.9
142.48
331.35
mg/l
1.32
154
71
113
40
35.69
173.00
2.8
2.2
32.32
35.25
%
0.59
113
40
106
32
41.21
170.07
2.9
3.2
29.53
43.64
%
2.92
16
18
274
617
8.17
130.61
4.8
1.8
—
—
—
0
0
271
702
6.89
108.99
6.1
1.7
—
—
—
0
0
183
469
5.45
70.30
4.9
1.5
—
—
—
0
0
154
427
4.68
52.23
2.2
3.0
31.90
42.31
u/l
0.48
146
364
64
97
7.37
41.31
1.2
1.1
—
—
—
0
0
227
966
3.37
39.87
4.1
3.4
—
0.00
—
0
8
290
1533
2.98
33.40
4.6
3.8
16.19
93.36
e6/l
1.96
157
1086
245
1185
2.99
33.16
8.9
2.0
—
—
—
0
0
59
105
6.20
32.51
1.2
1.1
—
—
—
0
0
252
1272
2.88
31.01
8.6
5.9
—
—
—
0
0
263
1442
2.64
26.36
11.1
6.4
—
—
—
0
0
73
204
3.99
23.41
1.3
1.4
222.19
227.69
miu/ml
0.04
27
113
156
700
2.75
22.83
2.3
2.9
0.79
0.81
e6/l
0.05
61
366
372
2536
2.59
21.90
13.5
9.8
3.76
4.14
e9/l
2.84
332
2226
342
2272
2.44
20.83
7.4
6.8
13.04
12.01
umol/l
0.43
330
2171
206
1104
2.42
20.43
2.7
3.0
—
0.00
estimate
—
0
7
339
2264
2.39
20.08
12.2
6.6
0.58
0.58
e9/l
0.05
309
1966
339
2267
2.39
19.98
12.1
6.6
0.04
0.04
e9/l
0.75
309
1970
143
655
2.62
19.76
2.3
3.0
2.81
1.37
e6/l
0.53
48
318
344
2324
2.38
19.66
12.1
6.8
2.08
2.00
e9/l
0.50
316
2082
346
2345
2.38
19.61
12.1
7.0
0.19
0.20
e9/l
0.49
317
2079
295
1875
2.30
19.36
4.0
3.1
6.19
6.14
ph
0.23
108
1124
318
2090
2.32
19.21
12.7
6.8
8.88
8.79
%
0.32
305
1995
316
2079
2.30
18.93
12.7
6.6
2.80
2.90
%
0.41
303
1978
315
2073
2.29
18.81
12.8
6.8
0.74
0.69
%
1.20
302
1968
320
2122
2.29
18.73
12.4
6.5
53.09
56.93
%
7.44
310
2049
323
2155
2.29
18.56
12.6
6.6
32.42
28.16
%
8.56
311
2070
208
1158
2.32
18.53
2.8
3.1
0.22
0.33
e6/l
0.80
129
843
279
1761
2.24
18.26
5.2
5.4
37.84
36.69
g/l
2.65
263
1681
175
924
2.34
17.46
2.1
1.7
—
—
—
0
0
224
1337
2.17
16.36
3.0
3.2
16.54
101.90
e6/l
1.08
146
1022
50
143
3.76
15.39
1.6
1.3
—
—
—
0
0
296
2009
2.08
14.99
15.4
10.7
0.00
0.00
e9/l
0.46
251
1650
326
2306
2.08
14.60
4.0
3.3
0.00
0.00
estimate
-0.00
42
490
329
2336
2.09
14.57
4.1
3.4
0.00
0.02
estimate
1.06
38
442
328
2333
2.07
14.37
4.0
3.3
0.00
3.31
estimate
0.50
42
491
416
3276
2.28
13.49
9.6
8.3
76.20
77.53
u/l
0.30
408
3142
251
1667
1.97
12.84
10.4
3.3
36.55
34.95
u/l
0.10
241
1586
102
501
2.28
11.55
1.8
1.7
—
—
—
0
0
37
113
3.45
10.33
2.1
1.1
—
—
—
0
0
334
2607
1.77
8.82
4.2
3.9
382.00
137.18
e6/l
—
5
39
20
47
4.38
8.00
1.9
1.7
—
—
—
0
0
324
2548
1.71
7.93
6.1
5.5
6.39
6.70
mmol/l
2.18
318
2409
495
4474
2.75
7.63
15.4
14.0
24.51
23.45
mg/l
0.32
428
3622
255
1913
1.65
7.23
2.2
1.9
1.41
1.49
mmol/l
0.87
241
1680
105
639
1.80
6.32
2.4
2.1
—
—
—
0
0
28
99
2.93
6.20
1.7
1.4
—
—
—
0
0
27
94
2.97
6.14
2.4
3.4
2.00
2.77
index
—
8
59
36
148
2.54
6.00
2.1
3.4
—
—
—
0
0
38
162
2.45
5.88
2.3
3.1
1.12
1.32
mg/l
2.20
32
151
17
45
3.87
5.85
2.1
1.5
—
—
—
0
0
200
1507
1.53
5.05
3.2
3.6
8.81
8.76
mmol/l
0.04
177
1317
49
250
2.06
4.97
3.0
3.5
23.77
24.37
mmol/l
0.55
49
250
56
300
1.97
4.97
2.0
1.8
0.26
0.35
mg/l
0.72
32
153
90
563
1.72
4.88
1.6
1.5
—
—
—
0
0
49
253
2.03
4.82
1.2
1.2
—
—
—
0
0
164
2153
0.65
4.77
3.0
2.9
—
—
—
0
0
61
349
1.85
4.46
1.8
2.4
—
—
—
0
0
112
760
1.60
4.42
2.5
2.5
15.26
14.34
nmol/l
0.57
106
717
130
914
1.56
4.41
2.6
2.5
4.39
5.69
e6/l
0.56
118
837
182
1376
1.49
4.40
2.3
2.3
—
—
—
0
0
64
378
1.79
4.22
1.8
2.3
—
—
—
0
0
64
379
1.78
4.19
1.8
2.3
—
—
—
0
0
63
373
1.78
4.13
1.8
2.3
—
—
—
0
0
59
343
1.81
4.10
2.0
2.0
40.41
36.61
nmol/l
0.52
59
333
7
7
10.11
4.02
3.0
1.4
—
—
—
0
0
152
1138
1.47
3.77
4.6
4.5
—
—
—
0
0
142
1054
1.48
3.67
1.7
1.6
19.84
19.64
nmol/l
0.06
127
914
25
111
2.31
3.60
1.8
1.4
23.65
21.96
e6/l
0.04
17
81
61
373
1.72
3.59
1.8
2.1
—
—
—
0
0
458
4230
1.63
3.56
6.0
4.5
5.91
5.92
mmol/l
0.01
437
3977
503
4781
2.14
3.43
23.8
17.1
78.12
79.27
umol/l
0.56
503
4743
25
114
2.25
3.40
1.8
1.4
474.65
855.40
e6/l
0.21
17
85
9
18
5.07
3.38
4.6
2.1
35.89
33.61
%
—
9
18
214
1746
1.38
3.19
6.2
7.3
1.20
1.21
mmol/l
0.64
200
1645
193
1550
1.39
3.16
2.3
2.0
—
—
—
0
0
14
50
2.85
3.11
1.4
1.8
—
—
—
0
0
20
87
2.35
3.04
2.1
2.6
1.56
2.11
mmol/l
0.73
15
57
17
69
2.51
2.99
1.0
1.2
—
—
—
0
0
38
214
1.84
2.97
1.5
1.6
7.84
6.18
u/l
0.39
30
181
29
149
2.00
2.96
1.2
1.1
—
—
—
0
0
109
801
1.45
2.92
2.5
2.6
572.22
557.01
mosm/kgh2o
0.24
95
707
47
286
1.71
2.84
1.9
2.0
230.15
220.59
pmol/l
0.25
47
273
97
701
1.47
2.83
2.9
2.9
2.43
2.43
mmol/l
0.32
84
628
12
39
3.12
2.78
1.0
1.1
—
—
—
0
0
5
6
8.40
2.75
1.4
1.3
—
—
—
0
0
11
34
3.28
2.74
1.0
1.1
—
—
—
0
0
163
1299
1.37
2.73
3.2
3.5
2.36
2.35
mmol/l
0.35
148
1201
472
4447
1.59
2.71
16.5
16.0
3.94
3.98
mmol/l
2.90
463
4366
88
630
1.48
2.69
1.4
1.4
446.67
403.31
titre
0.16
18
121
202
1674
1.34
2.60
2.2
1.9
98.60
95.61
pmol/l
0.37
122
908
32
179
1.84
2.58
1.3
1.3
—
—
—
0
0
470
4437
1.55
2.52
16.4
15.9
139.39
139.68
mmol/l
2.05
465
4367
448
4193
1.46
2.46
6.9
5.6
37.83
38.76
mmol/mol
0.45
437
4017
29
160
1.86
2.44
4.0
10.4
—
—
—
0
0
146
1163
1.35
2.42
3.4
4.2
7.40
7.40
ph
0.09
91
824
9
27
3.37
2.40
1.3
1.6
—
3280.00
—
0
5
72
509
1.48
2.35
1.3
1.2
—
—
—
0
0
62
426
1.52
2.32
2.3
2.8
1.63
1.79
%
0.89
57
389
14
59
2.41
2.31
1.4
1.4
196.17
165.48
pmol/l
0.73
14
59
19
93
2.08
2.24
2.4
2.6
—
—
—
0
0
5
9
5.60
2.22
3.6
1.6
—
—
—
0
0
17
80
2.16
2.21
1.1
1.0
2.20
1.79
eliau/ml
—
7
36
213
1814
1.29
2.16
2.5
2.5
75.57
73.38
nmol/l
0.50
194
1677
80
587
1.43
2.16
2.0
2.5
25.63
24.89
%
0.14
75
558
24
131
1.87
2.11
1.1
1.1
—
—
—
0
0
24
132
1.86
2.07
1.1
1.1
—
—
—
0
0
125
995
1.34
2.06
1.5
1.4
2.55
2.44
g/l
0.32
72
684
123
980
1.33
2.01
2.3
2.0
2.79
2.73
mg/l
0.10
107
857
38
242
1.61
1.99
1.2
2.3
—
—
—
0
0
56
390
1.49
1.98
2.0
2.6
0.22
0.22
g/l
0.14
51
365
139
1131
1.31
1.96
2.5
2.6
351.00
358.14
umol/l
0.40
130
1030
8
28
2.88
1.87
1.0
1.3
130.88
156.78
nmol/l
—
8
28
111
1374
0.76
1.86
3.0
2.7
0.00
0.00
estimate
0.50
34
396
54
385
1.45
1.72
8.3
10.9
—
—
—
0
0
512
4991
1.91
1.71
26.7
20.7
252.42
247.74
e9/l
0.89
504
4923
45
311
1.49
1.68
1.5
1.4
—
—
—
0
0
83
642
1.35
1.66
2.0
2.5
2.29
2.31
g/l
0.10
78
598
7
25
2.82
1.65
1.6
3.4
909.57
736.84
u/ml
—
7
25
38
255
1.53
1.63
1.6
1.2
—
—
—
0
0
126
1039
1.28
1.59
3.3
3.3
1.02
1.02
kg/l
1.38
65
676
10
43
2.35
1.59
1.1
1.2
39.64
51.78
mg/l
—
10
31
512
4998
1.86
1.59
26.7
20.7
6.81
6.68
e9/l
0.68
499
4922
512
4998
1.86
1.59
26.6
20.6
4.58
4.67
e12/l
3.89
499
4922
113
925
1.28
1.51
2.9
2.7
—
—
—
0
0
0
45
0.00
1.50
0.0
2.5
—
105.89
—
0
45
0
45
0.00
1.50
0.0
2.5
—
4.03
—
0
45
0
45
0.00
1.50
0.0
2.5
—
1.18
—
0
45
353
3282
1.23
1.43
3.7
3.8
14.70
14.64
pmol/l
0.16
330
3045
99
805
1.28
1.40
3.1
3.5
1314.97
691.69
ng/l
0.22
72
574
224
1996
1.21
1.38
2.8
2.7
—
—
estimate
—
0
0
9
42
2.16
1.34
1.1
1.1
271.67
253.18
mg/l
—
9
34
81
646
1.30
1.33
2.8
2.8
92.68
125.56
ug/g
0.95
64
538
0
40
0.00
1.33
0.0
1.5
—
76.60
—
0
40
220
1963
1.21
1.33
6.1
7.9
1.20
1.21
mmol/l
0.15
192
1734
76
603
1.30
1.30
7.7
8.3
104.79
104.05
mmol/l
0.85
76
603
43
313
1.41
1.27
2.0
2.9
65.20
71.14
e9/l
0.63
29
217
54
410
1.35
1.25
3.5
3.6
0.67
1.82
mmol/l
1.05
49
352
10
187
0.53
1.21
6.2
7.6
2.28
1.59
%
—
10
172
55
422
1.34
1.19
3.6
3.7
7.37
7.38
ph
0.42
25
242
17
102
1.69
1.17
1.1
1.0
2.70
8.51
u/ml
—
8
62
0
33
0.00
1.16
0.0
2.9
—
48.82
—
0
33
0
33
0.00
1.16
0.0
5.8
—
7.97
—
0
33
0
35
0.00
1.15
0.0
1.7
—
6.17
—
0
26
226
2043
1.19
1.14
2.9
2.9
132.57
139.17
ug/l
0.18
215
1948
7
32
2.20
1.08
1.6
1.5
—
—
—
0
0
63
501
1.29
1.08
8.0
10.7
7.41
7.42
ph
0.21
37
274
45
585
0.75
1.08
1.5
1.4
—
—
—
0
0
7
33
2.14
1.06
1.0
1.3
—
—
—
0
0
16
98
1.65
1.04
1.1
1.0
6.13
0.64
u/ml
—
10
39
7
34
2.07
1.03
1.9
1.6
—
—
—
0
0
5
23
2.18
0.98
1.2
1.1
656.08
157.89
iu/ml
—
5
23
10
54
1.87
0.97
1.1
1.9
8.25
11.44
%
—
10
54
0
31
0.00
0.96
0.0
1.3
—
—
—
0
0
19
125
1.54
0.95
1.0
1.2
315.85
259.03
u/ml
0.41
13
77
22
151
1.48
0.92
1.7
2.1
0.39
1.70
ug/l
1.29
17
133
61
497
1.26
0.89
8.2
10.7
0.33
0.91
mmol/l
0.63
53
423
13
79
1.66
0.88
1.2
1.0
0.16
0.38
u/ml
—
6
25
16
103
1.57
0.88
2.4
3.3
55.13
57.61
%
0.39
16
103
22
153
1.46
0.87
1.2
1.3
—
—
—
0
0
30
222
1.37
0.85
1.3
1.3
—
—
—
0
0
6
31
1.95
0.84
1.0
1.0
—
—
—
0
0
8
46
1.75
0.83
2.8
1.3
6.35
7.00
g/l
—
8
30
8
46
1.75
0.83
2.8
1.3
0.57
0.40
g/l
—
8
29
23
164
1.42
0.81
1.6
2.2
124.75
570.14
ug/l
1.00
23
158
8
47
1.71
0.81
2.8
1.3
—
—
—
0
0
33
251
1.34
0.80
4.2
6.7
—
—
—
0
0
0
24
0.00
0.79
0.0
1.5
—
—
—
0
0
6
33
1.83
0.79
2.7
1.8
—
—
—
0
0
0
26
0.00
0.78
0.0
1.3
—
35.57
—
0
19
46
369
1.27
0.77
1.2
1.2
—
—
—
0
0
6
34
1.77
0.76
1.5
1.5
16100.00
29490.41
e6/l
—
6
17
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
10
59
1.71
0.76
1.2
1.1
—
—
—
0
0
42
335
1.28
0.74
1.1
1.1
—
—
—
0
0
7
38
1.85
0.73
1.1
1.3
—
—
—
0
0
7
38
1.85
0.73
1.4
1.4
3324.57
2411.52
e6/l
—
7
23
5
25
2.01
0.73
2.6
3.5
89.40
126.32
nmol/l
—
5
25
63
531
1.21
0.70
2.2
2.8
11.00
8.74
umol/l
0.27
53
473
469
4582
1.21
0.69
6.9
5.1
2.80
2.80
mmol/l
0.01
451
4354
7
42
1.68
0.68
1.6
2.5
27.43
33.07
pg
—
7
42
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
7
43
1.64
0.67
1.3
1.1
—
—
—
0
0
143
1297
1.14
0.66
3.1
3.7
71.57
61.74
mg/l
0.13
88
890
10
62
1.62
0.65
4.6
3.5
1.75
1.06
%
—
10
57
123
1105
1.15
0.65
1.4
1.3
1.23
1.30
u/ml
0.06
33
327
66
564
1.19
0.64
2.0
3.7
4.20
6.13
e9/l
1.02
57
515
414
4012
1.15
0.64
4.8
4.6
1.76
1.85
mu/l
0.99
396
3757
84
735
1.17
0.63
1.9
1.5
—
—
—
0
0
24
182
1.33
0.62
2.6
2.6
262.90
4311.79
u/l
—
6
71
153
1400
1.13
0.61
2.9
2.9
61.01
64.21
u/l
0.18
141
1318
145
1324
1.13
0.60
3.7
4.3
13.46
10.12
mg/mmol
0.21
90
886
113
1017
1.14
0.59
1.8
1.7
1.13
1.16
mg/l
0.05
86
760
6
36
1.67
0.57
2.0
2.4
—
—
—
0
0
6
36
1.67
0.57
1.8
1.2
111.00
108.11
pmol/l
—
6
36
6
36
1.67
0.57
1.0
2.6
—
—
—
0
0
464
4544
1.18
0.56
6.3
4.7
4.61
4.65
mmol/l
0.40
446
4329
31
383
0.80
0.56
5.6
5.4
0.00
0.20
%
1.18
13
91
31
382
0.80
0.55
5.4
4.7
0.50
0.46
%
0.07
14
113
6
39
1.54
0.53
1.8
1.3
4.38
6.32
mmol/l
—
6
34
6
40
1.51
0.51
1.3
1.1
—
—
—
0
0
9
64
1.41
0.51
2.8
1.6
—
—
—
0
0
9
64
1.41
0.51
2.8
1.6
—
—
—
0
0
9
64
1.41
0.51
2.8
1.6
—
—
—
0
0
9
64
1.41
0.51
2.8
1.6
—
—
—
0
0
12
168
0.71
0.51
4.3
8.1
3.24
0.87
%
0.49
12
152
14
190
0.73
0.50
3.8
3.3
25.14
24.91
mmol/l
0.13
14
181
13
93
1.41
0.48
1.2
1.0
5.39
2.67
u/ml
—
7
49
5
81
0.61
0.46
1.0
1.1
—
—
—
0
0
16
121
1.33
0.44
1.3
1.1
3.04
2.39
u/ml
—
9
68
10
69
1.46
0.44
2.0
1.3
—
—
—
0
0
13
95
1.38
0.44
1.3
1.2
—
—
—
0
0
29
240
1.22
0.42
2.6
2.5
0.66
0.66
%
0.02
29
240
5
32
1.57
0.42
1.0
1.3
—
—
—
0
0
361
3506
1.09
0.41
3.3
3.4
46.22
48.23
u/l
0.21
343
3371
0
15
0.00
0.41
0.0
1.8
—
2.40
—
0
15
0
15
0.00
0.41
0.0
1.2
—
67.20
—
0
15
149
1393
1.10
0.41
1.4
1.5
—
—
—
0
0
440
4315
1.12
0.41
5.2
4.0
1.38
1.36
mmol/l
0.29
412
4079
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
23
186
1.25
0.41
1.5
1.9
1.83
5.08
iu/ml
—
6
40
11
79
1.40
0.41
1.1
1.5
—
—
—
0
0
79
716
1.12
0.39
1.3
1.3
10.07
7.14
u/ml
0.14
43
300
30
355
0.84
0.39
1.8
2.0
0.00
0.00
estimate
—
6
97
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
11
80
1.38
0.38
1.5
1.6
0.25
0.34
nmol/l
—
5
59
83
756
1.12
0.38
1.5
1.7
434.82
28097107.12
pmol/l
0.77
72
662
5
37
1.35
0.37
1.4
3.4
1389.80
1621.38
mg
—
5
37
11
81
1.37
0.36
3.2
3.6
3.67
4.11
e9/l
0.38
11
81
127
1186
1.09
0.36
2.6
2.6
0.59
0.70
ug/l
1.10
80
617
5
78
0.64
0.36
1.2
1.1
—
—
—
0
0
34
292
1.18
0.35
1.2
1.3
34.19
110.50
u/ml
—
9
118
6
43
1.40
0.35
1.0
1.0
—
—
—
0
0
6
46
1.31
0.33
1.8
1.2
—
—
—
0
0
6
89
0.67
0.33
7.2
12.3
12.67
11.74
mmol/l
—
6
77
6
89
0.67
0.33
7.2
12.3
104.33
105.00
mmol/l
—
6
77
35
401
0.86
0.32
5.2
4.8
1.14
0.87
%
0.25
18
126
15
119
1.27
0.32
1.1
1.4
—
—
—
0
0
12
151
0.79
0.28
4.5
2.3
25.27
24.92
mmol/l
0.12
12
151
24
279
0.85
0.27
1.3
1.1
0.71
0.67
ratio
—
6
29
474
4692
1.10
0.24
13.3
12.1
—
—
—
0
0
18
212
0.84
0.24
1.8
2.0
0.00
3.16
estimate
—
5
79
6
84
0.71
0.24
1.0
1.1
—
—
—
0
0
131
1249
1.06
0.23
3.8
3.4
0.00
0.01
estimate
0.69
37
455
12
97
1.24
0.23
2.4
2.2
143.29
134.93
g/l
—
7
72
34
378
0.89
0.22
5.4
4.9
0.00
0.13
%
2.61
17
102
158
1644
0.94
0.22
3.4
3.4
21.07
33.69
ng/l
1.89
93
1053
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
6.1
—
7.38
—
0
10
0
13
0.00
0.21
0.0
1.2
—
1.13
—
0
7
30
331
0.90
0.18
1.9
2.2
7.00
9.18
ug/l
0.58
25
301
11
91
1.21
0.17
1.5
1.2
5.00
4.34
u/ml
—
6
47
5
67
0.74
0.17
2.2
2.6
—
—
—
0
0
8
68
1.18
0.16
2.4
1.5
—
—
—
0
0
457
4533
1.06
0.15
6.3
4.6
1.32
1.37
mmol/l
1.73
436
4299
9
80
1.13
0.15
1.1
1.2
16.69
16.26
u/l
—
9
72
19
169
1.13
0.14
2.0
2.2
—
—
—
0
0
59
558
1.06
0.14
1.2
1.3
—
—
—
0
0
18
160
1.13
0.14
1.3
1.7
—
—
—
0
0
16
141
1.14
0.14
1.2
2.4
10.49
11.85
mg/l
0.49
16
134
34
316
1.08
0.13
3.8
4.6
7.38
7.34
ph
1.81
22
244
36
336
1.08
0.12
2.9
2.4
0.67
0.18
e6/l
0.94
30
323
12
104
1.16
0.12
3.0
2.0
8.78
8.37
kpa
0.54
12
104
17
152
1.12
0.12
1.6
1.9
—
—
—
0
0
311
3073
1.03
0.10
3.7
3.6
—
0.17
—
0
6
82
792
1.04
0.10
1.5
1.3
37.53
25.90
iu/ml
0.41
22
223
5
45
1.11
0.10
1.8
2.4
—
—
—
0
0
13
116
1.12
0.09
1.8
1.9
—
—
—
0
0
17
186
0.91
0.09
3.1
3.5
—
—
—
0
0
197
1938
1.03
0.09
4.6
4.1
2.82
1.76
ug/l
0.66
184
1784
6
54
1.11
0.09
2.3
3.2
1.32
2.83
nmol/l
—
6
54
6
70
0.86
0.07
3.2
2.3
—
—
—
0
0
54
523
1.04
0.06
1.4
1.4
—
—
—
0
0
27
284
0.95
0.06
3.2
3.2
5.07
5.15
kpa
0.21
27
277
19
202
0.94
0.05
1.1
1.1
—
—
—
0
0
112
1139
0.98
0.05
5.3
5.1
—
—
—
0
0
51
525
0.97
0.05
1.9
1.7
3.42
3.52
mmol/l
0.26
38
370
27
282
0.96
0.04
2.6
3.1
120.67
133.42
g/l
1.37
27
272
34
328
1.04
0.04
1.9
2.1
5.80
6.12
ph
1.51
20
208
12
111
1.08
0.04
1.1
2.6
0.99
1.72
ratio
—
7
60
56
550
1.02
0.02
1.6
1.6
1139.91
1204.12
nmol/l
0.23
43
432
25
258
0.97
0.02
11.4
13.2
16.32
16.26
%
0.03
25
247
25
243
1.03
0.01
1.2
1.6
—
—
—
0
0
35
357
0.98
0.01
3.7
3.4
—
—
—
0
0
44
433
1.02
0.01
10.1
11.6
124.80
125.14
g/l
0.04
44
422
13
136
0.95
0.00
2.8
2.8
—
—
—
0
0
19
184
1.03
0.00
1.4
1.2
0.52
1.92
u/ml
—
5
15
27
272
0.99
0.00
3.2
3.3
7.40
7.42
ph
0.55
20
228
187
1868
1.00
0.00
11.9
11.3
1.22
1.18
inr
0.42
144
1547
0
7
0.00
0.00
0.0
1.1
—
87.34
—
0
7
0
7
0.00
0.00
0.0
1.3
—
2.13
—
0
7
9
96
0.94
-0.00
1.8
1.6
—
—
—
0
0
182
1820
1.00
-0.00
3.3
3.1
0.00
0.01
estimate
0.74
34
412
0
9
0.00
-0.00
0.0
1.2
—
0.04
—
0
9
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
206.60
—
0
5
0
5
0.00
-0.00
0.0
5.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.3
26.64
32.47
ng/l
—
5
50
5
59
0.85
-0.00
1.2
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
1.20
—
0
9
0
8
0.00
-0.00
0.0
2.8
—
—
—
0
0
9
95
0.95
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
402.00
—
0
5
0
5
0.00
-0.00
0.0
3.4
—
1.04
—
0
5
9
96
0.94
-0.00
1.8
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
60.00
—
0
5
5
50
1.00
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
0.20
—
0
5
7
78
0.90
-0.00
1.6
2.9
6.00
7.98
pmol/l
—
7
78
5
57
0.88
-0.00
1.2
1.2
1.33
1.57
nmol/l
—
5
52
8
87
0.92
-0.00
1.6
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
70.00
—
0
8
5
51
0.98
-0.00
3.0
2.4
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: AB1_EARLY_SYPHILIS_WIDE – Early syphilis, including avohilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).