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Early syphilis

EFO Endpoint Browser PheWeb

AB1_EARLY_SYPHILIS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A51
  • Hospital discharge: ICD-9 — 09[1]
  • Hospital discharge: ICD-8 — 09[1]
  • Cause of death: ICD-10 — A51
  • Cause of death: ICD-9 — 09[1]
  • Cause of death: ICD-8 — 09[1]

2 out of 7 registries used, show all original rules.

455

4. Check minimum number of events

None

455

5. Include endpoints

None

455

6. Filter based on genotype QC (FinnGen only)

413

Control definitions (FinnGen only)

Control exclude
AB1_SEXUAL_TRANSMISSION

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2515 815 1643
Only index persons 2222 742 1480
Unadjusted period prevalence (%)
Whole population 0.04 0.02 0.05
Only index persons 0.05 0.03 0.06
Median age at first event (years)
Whole population 36.88 33.67 38.63
Only index persons 36.48 32.83 38.31

-FinnGen-

Key figures

All Female Male
Number of individuals 413 109 304
Unadjusted period prevalence (%) 0.11 0.04 0.14
Median age at first event (years) 39.47 32.21 42.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
455
Matched controls
4550
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
31.3
287.9
225
138
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
153.6
230.9
115
10
A51.0
ICD-10 Finland
Primary genital syphilis
+∞
201.5
178
*
WW200
NOMESCO Finland
Immunization
29.6
157.7
111
49
A51.3
ICD-10 Finland
Secondary syphilis of skin and mucous membranes
+∞
156.5
141
*
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
66.0
154.3
86
16
A56.3
ICD-10 Finland
Chlamydial infection of anus and rectum
1478.4
120.6
112
*
A63.0
ICD-10 Finland
Anogenital (venereal) warts
37.4
110.2
70
22
A54.6
ICD-10 Finland
Gonococcal infection of anus and rectum
+∞
100.9
93
*
Y25
ICPC
Fear sexually transm disease male
11.6
91.6
106
116
A51.9
ICD-10 Finland
Early syphilis, unspecified
+∞
89.6
83
*
A54.5
ICD-10 Finland
Gonococcal pharyngitis
994.8
86.6
82
*
A54.0
ICD-10 Finland
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
+∞
68.5
64
*
Z29.2
ICD-10 Finland
Other prophylactic chemotherapy
132.6
55.2
58
5
Z21
ICD-10 Finland
Asymptomatic human immunodeficiency virus [HIV] infection status
199.4
52.1
53
*
A53.9
ICD-10 Finland
Syphilis, unspecified
+∞
49.9
47
*
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
87.0
49.1
54
7
09100
ICD-8 Finland
Early syphilis, symptomatic, Primary syphilis, except extragenital chancre
+∞
43.4
41
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
5.0
34.7
84
196
A56.4
ICD-10 Finland
Chlamydial infection of pharynx
+∞
27.4
26
*
A51.5
ICD-10 Finland
Early syphilis, latent
+∞
26.3
25
*
Z3231
NOMESCO Finland
Registered nurse
2.9
24.3
161
723
0913A
ICD-9 Finland
Early syphilis, symptomatic, Secondary syphilis of skin or mucous membranes
+∞
24.2
23
*
Y71
ICPC
Gonorrhoea male
+∞
23.1
22
*
Y70
ICPC
Syphilis male
+∞
22.1
21
*
Z25.1
ICD-10 Finland
Need for immunization against influenza
5.2
21.8
47
98
Z2221
NOMESCO Finland
Medical doctor
2.8
21.3
150
689
A60.0
ICD-10 Finland
Herpesviral infection of genitalia and urogenital tract
19.0
21.2
32
18
09120
ICD-8 Finland
Early syphilis, symptomatic, Secondary syphilis of skin and mucous membranes
+∞
21.0
20
*
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
109.9
19.7
21
*
Z20.2
ICD-10 Finland
Contact with and exposure to infections with a predominantly sexual mode of transmission
6.4
18.8
32
53
D06BB04
ATC
podophyllotoxin; topical
4.5
17.7
46
112
B23.0
ICD-10 Finland
Acute HIV infection syndrome
+∞
16.8
16
*
J01MA02
ATC
ciprofloxacin; systemic
2.3
16.6
196
1121
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
4.9
16.4
37
80
ZX114
NOMESCO Finland
Intramuscular
13.6
15.9
27
21
A51.4
ICD-10 Finland
Other secondary syphilis
+∞
15.7
15
*
A55
ICD-10 Finland
Chlamydial lymphogranuloma (venereum)
+∞
15.7
15
*
J05AB11
ATC
valaciclovir; oral
2.8
15.5
91
374
D11
ICPC
Diarrhoea
2.9
15.3
84
333
EB1AA, ,
SPAT
3.7
14.9
49
142
Y99
ICPC
Genital disease male other
23.2
14.3
20
9
ULA02
NOMESCO Finland
Kolposcopy
4.3
13.5
36
89
TAB00
NOMESCO Finland
Lumbar puncture
3.9
12.8
39
107
WX110, ,
SPAT
3.6
12.5
43
128
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.1
11.8
143
805
A52.1
ICD-10 Finland
Symptomatic neurosyphilis
+∞
11.5
11
*
J05AB01
ATC
aciclovir; systemic
2.3
11.4
105
528
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
11.4
110
565
Z71.8
ICD-10 Finland
Other specified counselling
2.0
11.2
171
1046
EB1SA, ,
SPAT
3.6
11.1
38
113
A52.9
ICD-10 Finland
Late syphilis, unspecified
+∞
10.5
10
*
A54.9
ICD-10 Finland
Gonococcal infection, unspecified
+∞
10.5
10
*
WNF00
NOMESCO Finland
Infection source and contact determination
33.4
10.4
13
*
WX290, ,
SPAT
4.3
10.3
27
66
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
4.6
10.1
24
54
Z20.6
ICD-10 Finland
Contact with and exposure to human immunodeficiency virus [HIV]
26.7
9.9
13
5
A97
ICPC
No disease
2.2
9.8
101
530
J01AA02
ATC
doxycycline; systemic
2.0
9.7
346
2765
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
11.7
9.6
17
15
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
2.9
9.4
45
164
J01FA10
ATC
azithromycin; systemic
1.9
9.4
271
2009
J01DB01
ATC
cefalexin; oral
2.3
9.2
387
3247
I84
ICD-10 Finland
Hemorrhoids
4.9
9.1
20
42
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.9
8.9
138
836
F43.29
ICD-10 Finland
Adaptation disorder UNS
4.7
8.7
20
44
U07
ICPC
Urine symptom/complaint other
2.9
8.6
40
144
A56.2
ICD-10 Finland
Chlamydial infection of genitourinary tract, unspecified
28.1
8.5
11
*
N48.1
ICD-10 Finland
Balanoposthitis
3.4
8.5
31
96
0910A
ICD-9 Finland
Early syphilis, symptomatic, Genital syphilis (primary)
+∞
8.4
8
*
A53.0
ICD-10 Finland
Latent syphilis, unspecified as early or late
+∞
8.4
8
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
8.0
99
552
EMB10
NOMESCO Finland
Tonsillectomy
3.0
8.0
36
127
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
1.9
7.7
111
652
B17.1
ICD-10 Finland
Acute hepatitis C
25.5
7.6
10
*
LDA10
NOMESCO Finland
Curettage of cervix uteri
7.0
7.4
17
25
A51.1
ICD-10 Finland
Primary anal syphilis
+∞
7.3
7
*
A03.3
ICD-10 Finland
Shigellosis due to Shigella sonnei
+∞
7.3
7
*
A03.1
ICD-10 Finland
Shigellosis due to Shigella flexneri
+∞
7.3
7
*
LEB00
NOMESCO Finland
Biopsy of vagina
9.0
7.1
14
16
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.1
7.1
29
97
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.1
7.0
68
346
J35.0
ICD-10 Finland
Chronic tonsillitis
3.0
6.9
31
109
B37.4
ICD-10 Finland
Candidiasis of other urogenital sites
17.0
6.8
10
6
R83
ICPC
Respiratory infection other
1.8
6.7
136
887
N48.8
ICD-10 Finland
Other specified disorders of penis
8.9
6.6
13
15
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.5
6.6
41
172
N05BA04
ATC
oxazepam; oral
1.8
6.5
111
687
N06AX11
ATC
mirtazapine; oral
1.7
6.4
155
1058
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
6.7
6.4
15
23
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.4
6.3
42
182
D06AX01
ATC
fusidic acid; topical
2.3
6.3
49
228
A52.8
ICD-10 Finland
Late syphilis, latent
+∞
6.3
6
*
A52.3
ICD-10 Finland
Neurosyphilis, unspecified
+∞
6.3
6
*

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Unspecified human immunodeficiency virus [HIV] disease
B24 (45547443)
Chlamydial infection of anus and rectum
A56.3 (45542533)
Gonococcal pharyngitis
A54.5 (45600426)
HIV disease resulting in other specified conditions
B23.8 (45561749)
Asymptomatic human immunodeficiency virus [HIV] infection status
Z21 (45566407)
Gonococcal infection of anus and rectum
A54.6 (45581125)
Other prophylactic chemotherapy
Z29.2 (45600313)
Secondary syphilis of skin and mucous membranes
A51.3 (45537730)
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
A54.0 (45547416)
Primary genital syphilis
A51.0 (45566511)
Early syphilis, unspecified
A51.9 (45600417)
Syphilis, unspecified
A53.9 (45600422)
Treponema pallidum Ab [Titer] in Serum by Hemagglutination
26009-1 (3019539)
Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture
698-1 (3028334)
Reagin Ab [Titer] in Serum by VDRL
50690-7 (3029634)
HIV disease resulting in (persistent) generalized lymphadenopathy
B23.1 (45532868)
Early syphilis, latent
A51.5 (45571434)
SMOKING - SMOKE2: no - SMOKE3: former - SMOKE5: Unspecified
SMOKING-2-2-0 (2002330110)
CD4 cells/Lymphocytes in Specimen
80223-1 (21494815)
tenofovir disoproxil and emtricitabine
J05AR03 (21603183)
HIV 1 RNA [Units/volume] (viral load) in Serum or Plasma by Probe with amplification
10351-5 (3013180)
CD3+CD4+ (T4 helper) cells/cells in Blood
8123-2 (3014037)
CD3+CD4+ (T4 helper) cells [#/volume] in Blood
24467-3 (3028167)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
Early syphilis, symptomatic, Secondary syphilis of skin or mucous membranes
0913A (2000400743)
Kolposcopy
ULA02 (2001306679)
Intramuscular
ZX114 (2001311493)
Medical doctor
Z2221 (2001311556)
SMOKING - SMOKE2: no - SMOKE3: never - SMOKE5: Unspecified
SMOKING-2-3-0 (2002330113)
SMOKING - SMOKE2: yes - SMOKE3: current - SMOKE5: Unspecified
SMOKING-1-1-0 (2002330116)
Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
21416-3 (3003510)
Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
21613-5 (3006093)
Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
24111-7 (3011371)
Hepatitis C virus Ab [Presence] in Serum
16128-1 (3017143)
Treponema pallidum Ab [Presence] in Serum
22587-0 (3019832)
Hepatitis B virus core Ab [Presence] in Serum
16933-4 (3021879)
Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
6357-8 (3024950)
Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection
20444-6 (3028369)
Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay
40724-7 (3040363)
Infectious Disease
44 (38004484)
Venereal disease screening
171128005 (4064905)
HIV 1 and 2 tests - Meaningful Use set
75622-1 (46235355)
Inpatient Hospital
21 (8717)
Inpatient Visit
IP (9201)
Clinical & Laboratory Dermatological Immunology Physician
207NI0002X (38003841)
Protein [Mass/volume] in Urine
2888-6 (3037121)
Phosphate [Moles/volume] in Serum or Plasma
14879-1 (3003458)
Outpatient Visit
OP (9202)
Treatment of a patient needing special arrangements
WYA30 (2001310874)
Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1920-8 (3013721)
Short blood count panel - Blood
55429-5 (40758558)
Fear sexually transm disease male
Y25 (2002001393)
Bilirubin.total [Moles/volume] in Serum or Plasma
14631-6 (3006140)
Supplier / Service Provider
OMOP5117446 (33004)
sildenafil; oral
G04BE03 (21602648)
Basophils/Leukocytes in Blood
30180-4 (3022096)
Differential panel, method unspecified - Blood
69738-3 (42870588)
Eosinophils/Leukocytes in Blood
26450-7 (3006504)
Monocytes/Leukocytes in Blood
26485-3 (3019069)
Neutrophils/Leukocytes in Blood
26511-6 (3018010)
Lymphocytes/Leukocytes in Blood
26478-8 (3002030)
Normoblasts [#/volume] in Blood
715-3 (3021589)
Monocytes [#/volume] in Blood
26484-6 (3001604)
Basophils [#/volume] in Blood
26444-0 (3006315)
Laboratory Visit
OMOP4822461 (32036)
Lymphocytes [#/volume] in Blood
26474-7 (3019198)
Eosinophils [#/volume] in Blood
26449-9 (3013115)
Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
1805-1 (3016417)
Hepatitis B virus surface Ag [Presence] in Serum
5195-3 (3019284)
Neutrophils [#/volume] in Blood by Automated count
751-8 (3013650)
Urinalysis macro (dipstick) panel - Urine
24357-6 (3037467)
Emergency Room Visit
ER (9203)
Hemoglobin [Presence] in Urine by Test strip
5794-3 (3011397)
Leukocytes [#/volume] in Urine
30405-5 (3018095)
Protein [Presence] in Urine by Test strip
20454-5 (3014051)
Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
6768-6 (3035995)
Diarrhoea
D11 (2002000310)
pH of Urine
2756-5 (3015736)
Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M
62238-1 (40764999)
azithromycin; oral, parenteral
J01FA10 (21602978)
Albumin [Mass/volume] in Serum or Plasma
1751-7 (3024561)
Case Management Agency
251B00000X (38004193)
Prothrombin time (PT) actual/Normal
5894-1 (3033658)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
ciprofloxacin; oral, parenteral
J01MA02 (21603009)
Pharmacy visit
OMOP4822462 (581458)
MCHC [Entitic Mass/volume] in Red Blood Cells
28540-3 (3003338)
Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1742-6 (3006923)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
cefalexin; oral
J01DB01 (21602870)
valaciclovir; oral
J05AB11 (21603137)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Platelets [#/volume] in Blood
26515-7 (3007461)
MCH [Entitic mass]
28539-5 (3035941)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)
Glucose [Moles/volume] in Serum or Plasma
14749-6 (3013826)
Immunization
WW200 (2001310599)
Anogenital (venereal) warts
A63.0 (45585929)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
252
74
75.09
307.65
13.5
1.9
9.27
—
titre
—
128
0
173
133
20.37
193.02
6.5
3.9
143.27
351.56
mg/l
1.31
151
64
111
34
42.86
178.29
2.9
2.3
32.22
34.65
%
0.40
111
34
105
28
48.45
174.86
2.8
3.1
28.30
40.70
%
2.30
15
15
237
374
12.14
161.92
5.0
1.7
—
—
—
0
0
247
572
8.26
115.00
6.6
1.7
—
—
—
0
0
173
386
6.62
79.72
5.1
1.5
—
—
—
0
0
146
379
5.20
54.74
2.2
3.1
32.21
43.73
u/l
0.47
141
325
62
87
8.09
43.04
1.2
1.1
—
—
—
0
0
210
835
3.81
42.90
4.2
3.4
—
0.00
—
0
8
202
872
3.37
34.80
10.0
1.9
—
—
—
0
0
262
1332
3.28
34.07
4.7
3.8
16.26
97.24
e6/l
1.74
138
954
57
95
6.72
33.67
1.2
1.1
—
—
—
0
0
67
141
5.40
31.02
1.3
1.5
235.37
226.07
miu/ml
0.05
22
74
228
1120
3.08
30.55
8.8
6.0
—
—
—
0
0
240
1267
2.89
27.35
11.3
6.6
—
—
—
0
0
143
617
2.92
23.07
2.2
2.9
0.83
0.86
e6/l
0.04
53
320
334
2211
2.92
23.02
13.5
10.2
3.72
4.15
e9/l
3.03
298
1934
148
662
2.83
22.21
2.1
1.7
—
—
—
0
0
306
1975
2.68
21.47
12.5
6.8
0.58
0.59
e9/l
0.03
280
1715
306
1978
2.67
21.35
12.5
6.8
0.04
0.04
e9/l
0.58
280
1719
309
2016
2.66
21.00
12.5
7.0
2.07
1.97
e9/l
0.68
283
1804
288
1824
2.58
20.71
13.0
7.1
8.97
8.81
%
0.53
279
1740
290
1849
2.57
20.46
12.7
6.8
52.65
57.17
%
9.10
282
1787
286
1812
2.56
20.44
13.1
6.9
2.78
2.92
%
0.61
277
1725
310
2043
2.62
20.33
12.5
7.2
0.19
0.20
e9/l
0.67
283
1812
285
1807
2.54
20.27
13.1
7.1
0.74
0.69
%
1.15
276
1714
185
961
2.56
20.26
2.6
3.0
—
0.00
estimate
—
0
6
131
574
2.80
20.21
2.2
3.0
2.61
1.16
e6/l
0.46
41
276
264
1621
2.50
20.06
4.1
3.1
6.14
6.12
ph
0.06
88
978
291
1873
2.54
19.88
12.9
6.9
32.72
27.81
%
9.84
283
1799
187
1012
2.44
18.36
2.7
3.1
0.23
0.34
e6/l
0.77
114
736
255
1585
2.39
18.23
5.3
5.5
37.79
36.58
g/l
2.60
241
1511
47
118
4.33
17.38
1.6
1.2
—
—
—
0
0
301
2039
2.41
17.29
7.8
7.0
13.43
12.26
umol/l
0.43
293
1949
201
1172
2.28
16.13
2.9
3.2
17.56
101.87
e6/l
0.88
130
895
262
1725
2.22
15.35
15.5
11.0
0.00
0.00
e9/l
0.47
221
1412
286
1991
2.18
14.04
4.1
3.3
0.00
0.00
estimate
-0.00
30
404
287
2012
2.15
13.69
4.1
3.3
0.00
3.97
estimate
0.50
30
409
287
2018
2.14
13.50
4.2
3.3
0.00
0.03
estimate
1.06
27
362
226
1480
2.05
12.55
11.1
3.4
37.19
35.74
u/l
0.08
217
1411
367
2887
2.40
12.50
9.8
8.7
76.99
78.40
u/l
0.29
361
2770
34
94
3.83
11.01
2.2
1.1
—
—
—
0
0
86
440
2.18
8.82
1.7
1.7
—
—
—
0
0
233
1694
1.77
8.16
2.2
1.9
1.42
1.49
mmol/l
0.65
220
1479
429
3853
2.98
7.39
15.6
14.7
26.16
24.05
mg/l
0.68
375
3121
18
42
4.42
7.28
2.1
1.8
—
—
—
0
0
17
41
4.27
6.60
2.1
1.5
—
—
—
0
0
26
89
3.04
6.10
1.8
1.4
—
—
—
0
0
133
1871
0.59
5.99
3.2
3.0
—
—
—
0
0
45
207
2.30
5.92
1.2
1.2
—
—
—
0
0
25
87
2.98
5.71
2.3
3.6
2.33
2.81
index
—
6
58
30
119
2.63
5.41
1.8
3.8
—
—
—
0
0
81
495
1.77
4.84
1.6
1.5
—
—
—
0
0
179
1342
1.55
4.77
3.2
3.7
8.92
8.71
mmol/l
0.18
158
1165
32
145
2.30
4.39
2.2
3.1
1.11
1.34
mg/l
2.16
27
134
45
235
2.02
4.34
2.8
3.4
23.71
24.37
mmol/l
0.58
45
235
104
700
1.63
4.33
2.5
2.5
15.62
14.58
nmol/l
0.64
99
661
50
274
1.93
4.21
1.6
2.6
—
—
—
0
0
113
800
1.55
3.76
2.6
2.5
3.79
4.19
e6/l
0.21
104
732
54
316
1.80
3.72
2.0
2.0
39.72
36.72
nmol/l
0.40
54
308
23
97
2.44
3.71
1.9
1.4
26.60
24.50
e6/l
0.04
15
70
28
132
2.19
3.53
1.3
1.1
—
—
—
0
0
138
1033
1.48
3.51
4.4
4.6
—
—
—
0
0
6
6
10.11
3.50
3.2
1.5
—
—
—
0
0
23
100
2.37
3.49
1.9
1.5
537.87
990.45
e6/l
0.22
15
73
47
269
1.83
3.49
1.7
1.7
0.23
0.35
mg/l
1.26
26
135
86
583
1.59
3.44
2.4
2.2
—
—
—
0
0
50
296
1.77
3.33
1.6
2.5
—
—
—
0
0
50
296
1.77
3.33
1.6
2.5
—
—
—
0
0
126
935
1.48
3.32
1.7
1.6
20.41
19.75
nmol/l
0.22
114
809
438
4164
2.39
3.26
24.6
18.0
79.09
80.51
umol/l
0.70
438
4135
49
291
1.77
3.23
1.6
2.6
—
—
—
0
0
15
55
2.79
3.18
1.0
1.2
—
—
—
0
0
15
55
2.79
3.18
1.1
1.1
1.83
1.20
eliau/ml
—
6
24
30
154
2.01
3.07
1.2
1.3
—
—
—
0
0
8
16
5.07
3.06
5.0
2.0
35.50
34.81
%
—
8
16
88
624
1.51
2.87
3.0
3.0
2.43
2.44
mmol/l
0.21
75
558
189
1546
1.38
2.83
6.6
7.6
1.20
1.21
mmol/l
0.62
177
1460
12
39
3.13
2.79
1.0
1.1
—
—
—
0
0
17
72
2.41
2.76
2.0
2.7
1.84
2.18
mmol/l
0.36
12
48
150
1185
1.40
2.75
2.4
2.4
—
—
—
0
0
11
34
3.29
2.74
1.0
1.1
—
—
—
0
0
396
3684
1.58
2.74
6.3
4.7
5.98
5.96
mmol/l
0.09
377
3470
14
54
2.64
2.73
1.4
1.5
196.17
166.12
pmol/l
0.71
14
54
27
140
1.99
2.71
1.1
1.3
—
—
—
0
0
27
140
1.99
2.71
4.2
11.1
—
—
—
0
0
397
3698
1.58
2.70
7.2
5.8
37.94
39.03
mmol/mol
0.47
387
3543
132
1028
1.40
2.62
3.5
4.2
7.40
7.40
ph
0.00
78
733
47
294
1.67
2.60
1.6
2.3
—
—
—
0
0
5
7
7.21
2.55
3.6
1.7
—
—
—
0
0
65
443
1.55
2.54
1.3
1.2
—
—
—
0
0
43
266
1.68
2.49
1.8
2.0
237.16
222.14
pmol/l
0.42
43
254
89
1180
0.69
2.46
3.0
2.7
0.00
0.00
estimate
0.50
23
324
94
697
1.44
2.44
2.5
2.7
584.99
559.45
mosm/kgh2o
0.44
82
614
178
1470
1.35
2.42
2.2
2.0
97.15
95.96
pmol/l
0.13
108
799
23
118
2.00
2.40
1.1
1.1
—
—
—
0
0
108
825
1.41
2.38
1.5
1.4
2.64
2.54
g/l
0.21
60
562
23
119
1.98
2.35
1.1
1.1
—
—
—
0
0
77
554
1.47
2.34
1.4
1.4
422.86
342.26
titre
0.32
14
106
17
78
2.23
2.34
2.4
2.8
—
—
—
0
0
410
3883
1.57
2.17
16.8
16.9
3.94
3.99
mmol/l
2.99
402
3821
184
1552
1.31
2.10
2.5
2.5
77.06
73.90
nmol/l
0.74
170
1432
142
1159
1.33
2.04
3.3
3.6
2.36
2.35
mmol/l
0.35
128
1069
105
825
1.35
1.93
2.3
2.1
2.82
2.79
mg/l
0.05
92
722
29
177
1.68
1.81
1.5
1.5
6.30
6.16
u/l
0.03
21
148
159
1340
1.29
1.77
2.3
2.0
—
—
—
0
0
44
301
1.51
1.73
1.2
1.2
—
—
—
0
0
7
24
2.95
1.73
1.0
1.3
135.86
155.06
nmol/l
—
7
24
50
355
1.46
1.65
2.0
2.7
0.22
0.22
g/l
0.13
45
332
8
175
0.45
1.61
5.1
7.7
1.80
1.61
%
—
8
161
50
358
1.45
1.59
8.5
11.3
—
—
—
0
0
192
1676
1.25
1.56
2.8
2.8
144.66
153.19
ug/l
0.20
184
1599
75
580
1.35
1.53
1.9
1.4
—
—
—
0
0
96
772
1.31
1.51
3.0
2.8
—
—
—
0
0
9
37
2.46
1.48
1.1
1.2
40.27
53.98
mg/l
—
9
26
33
222
1.52
1.43
1.2
2.4
—
—
—
0
0
37
522
0.68
1.42
1.6
1.5
—
—
—
0
0
91
737
1.29
1.36
3.2
3.5
1393.62
727.50
ng/l
0.21
66
540
0
37
0.00
1.35
0.0
1.5
—
77.65
—
0
37
0
40
0.00
1.33
0.0
2.6
—
1.18
—
0
40
0
40
0.00
1.33
0.0
2.6
—
106.10
—
0
40
0
40
0.00
1.33
0.0
2.6
—
4.06
—
0
40
441
4307
1.78
1.32
27.1
21.5
250.84
245.46
e9/l
0.97
433
4248
10
48
2.11
1.28
1.1
1.8
8.25
11.03
%
—
10
48
300
2784
1.23
1.28
3.7
3.7
14.66
14.68
pmol/l
0.04
282
2581
8
36
2.24
1.25
1.1
1.1
274.13
261.00
mg/l
—
8
28
6
25
2.42
1.24
1.7
3.4
966.00
736.84
u/ml
—
6
25
441
4313
1.73
1.22
27.1
21.5
6.76
6.63
e9/l
0.57
428
4246
441
4313
1.73
1.22
27.1
21.4
4.59
4.69
e12/l
4.21
428
4246
25
165
1.55
1.20
1.2
1.4
—
11.45
—
0
6
195
1742
1.21
1.20
6.5
8.3
1.20
1.21
mmol/l
0.19
170
1545
8
38
2.12
1.19
2.8
1.3
0.57
0.41
g/l
—
8
25
8
38
2.12
1.19
2.8
1.3
6.35
7.18
g/l
—
8
26
8
39
2.07
1.16
2.8
1.3
—
—
—
0
0
5
20
2.52
1.15
1.0
1.0
—
—
—
0
0
7
30
2.35
1.12
1.9
1.6
—
—
—
0
0
7
30
2.35
1.12
1.0
1.3
—
—
—
0
0
120
1028
1.23
1.12
2.6
2.7
355.85
361.99
umol/l
0.32
112
932
59
466
1.31
1.08
8.0
11.1
7.42
7.42
ph
0.26
34
253
106
900
1.23
1.07
3.2
3.4
1.02
1.02
kg/l
1.33
49
581
69
558
1.28
1.06
8.2
8.7
104.64
104.02
mmol/l
0.64
69
558
5
22
2.29
1.03
1.2
1.1
656.08
161.98
iu/ml
—
5
22
30
214
1.43
1.02
1.5
1.2
—
—
—
0
0
14
83
1.71
1.02
1.1
1.0
1.86
8.25
u/ml
—
6
51
10
53
1.91
1.02
1.2
1.1
—
—
—
0
0
17
107
1.61
1.01
1.0
1.2
329.67
266.91
u/ml
0.42
12
65
49
381
1.32
1.01
3.3
3.6
0.61
1.83
mmol/l
1.04
44
325
58
463
1.29
0.99
8.2
11.1
0.35
0.98
mmol/l
0.65
50
399
5
23
2.19
0.98
2.6
3.7
89.40
132.17
nmol/l
—
5
23
0
29
0.00
0.98
0.0
1.3
—
—
—
0
0
50
392
1.31
0.97
3.5
3.7
7.37
7.38
ph
0.53
22
226
0
31
0.00
0.96
0.0
1.7
—
6.40
—
0
23
186
1681
1.18
0.96
3.0
2.8
—
—
estimate
—
0
0
0
32
0.00
0.95
0.0
2.8
—
48.06
—
0
32
0
32
0.00
0.95
0.0
5.6
—
8.00
—
0
32
12
70
1.73
0.93
2.3
2.2
0.72
0.99
g/l
0.38
12
56
38
288
1.35
0.93
1.9
2.9
64.62
71.37
e9/l
0.71
26
202
30
219
1.40
0.92
1.2
1.2
24.21
85.71
u/ml
—
8
88
38
289
1.34
0.91
1.1
1.1
—
—
—
0
0
6
30
2.01
0.87
2.7
1.8
—
—
—
0
0
6
30
2.01
0.87
1.7
1.5
—
—
—
0
0
25
179
1.42
0.86
1.3
1.3
—
—
—
0
0
13
80
1.64
0.85
1.2
1.0
8.24
0.70
u/ml
—
7
31
104
903
1.20
0.85
1.4
1.3
1.05
1.34
u/ml
0.28
25
280
11
65
1.71
0.83
1.2
1.0
0.07
0.43
u/ml
—
5
21
6
32
1.89
0.82
1.5
1.5
16100.00
31021.06
e6/l
—
6
16
14
90
1.57
0.79
2.6
3.4
53.64
58.35
%
0.82
14
90
6
34
1.77
0.76
1.0
2.7
—
—
—
0
0
6
34
1.77
0.76
1.2
1.3
—
—
—
0
0
25
333
0.74
0.75
5.3
5.6
0.00
0.12
%
1.11
11
83
36
282
1.30
0.74
1.6
1.4
—
—
—
0
0
100
878
1.18
0.72
1.8
1.8
1.17
1.22
mg/l
0.08
74
679
25
331
0.74
0.72
5.4
4.9
0.33
0.49
%
0.45
12
102
63
531
1.22
0.71
2.5
3.0
88.00
132.58
ug/g
1.28
52
448
10
157
0.63
0.70
3.1
8.3
3.67
0.88
%
—
10
142
9
58
1.56
0.70
2.8
1.6
—
—
—
0
0
9
58
1.56
0.70
2.8
1.6
—
—
—
0
0
9
58
1.56
0.70
2.8
1.6
—
—
—
0
0
9
58
1.56
0.70
2.8
1.6
—
—
—
0
0
136
1495
0.87
0.66
3.3
3.4
22.34
34.48
ng/l
1.54
81
990
30
233
1.31
0.66
3.8
6.8
—
—
—
0
0
5
28
1.79
0.66
1.0
1.2
—
—
—
0
0
21
155
1.37
0.64
1.6
2.3
132.40
594.27
ug/l
0.97
21
149
12
176
0.67
0.63
4.3
3.4
24.88
24.83
mmol/l
0.03
12
169
0
21
0.00
0.60
0.0
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
19
140
1.37
0.59
1.1
1.3
—
—
—
0
0
6
36
1.68
0.57
1.5
1.4
2278.67
2397.36
e6/l
—
6
22
6
36
1.68
0.57
1.3
1.1
—
—
—
0
0
11
73
1.52
0.56
1.2
1.0
0.57
2.39
u/ml
—
5
40
6
37
1.63
0.55
1.3
2.6
27.00
33.24
pg
—
6
37
6
39
1.55
0.53
1.3
1.2
—
—
—
0
0
129
1182
1.13
0.53
3.2
3.7
69.03
60.20
mg/l
0.11
80
804
10
66
1.53
0.53
2.0
1.3
—
—
—
0
0
21
161
1.32
0.52
1.5
1.9
1.80
5.58
iu/ml
—
5
35
131
1206
1.12
0.50
3.8
4.4
14.11
9.86
mg/mmol
0.25
82
797
14
102
1.38
0.48
1.1
1.3
—
—
—
0
0
10
68
1.48
0.47
3.4
3.7
3.47
4.28
e9/l
—
10
68
354
3443
1.13
0.47
4.8
4.5
1.80
1.87
mu/l
0.66
338
3221
29
350
0.82
0.45
4.9
4.9
0.84
0.89
%
0.05
16
115
27
220
1.24
0.45
2.6
2.5
0.66
0.66
%
0.01
27
220
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
27
223
1.22
0.40
2.6
2.6
1.25
1.38
%
0.34
27
223
5
34
1.48
0.40
2.0
1.2
102.40
107.94
pmol/l
—
5
34
5
34
1.48
0.40
1.6
1.8
—
—
—
0
0
13
97
1.35
0.40
1.3
1.1
3.37
2.72
u/ml
—
8
54
54
477
1.15
0.39
2.1
3.0
12.05
9.09
umol/l
0.32
46
432
5
35
1.43
0.39
1.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
5
37
1.36
0.37
2.0
1.1
—
—
—
0
0
119
1109
1.10
0.36
1.3
1.4
—
—
—
0
0
28
329
0.84
0.35
5.0
5.1
0.00
0.14
%
2.62
15
93
6
44
1.37
0.34
1.0
1.3
—
—
—
0
0
55
494
1.13
0.33
1.6
3.8
4.30
5.80
e9/l
0.70
47
453
10
74
1.36
0.32
1.1
1.6
—
—
—
0
0
11
83
1.33
0.32
2.5
2.2
147.17
133.25
g/l
—
6
59
12
92
1.31
0.32
3.0
2.1
8.78
8.29
kpa
0.68
12
92
27
311
0.86
0.28
1.9
2.3
6.94
9.33
ug/l
0.60
22
283
119
1126
1.08
0.26
2.7
2.7
0.59
0.70
ug/l
0.94
77
583
151
1579
0.93
0.26
3.4
3.1
0.00
0.01
estimate
0.74
23
338
406
4012
1.11
0.26
7.3
5.3
2.80
2.80
mmol/l
0.02
389
3812
9
76
1.19
0.24
1.1
1.2
16.69
16.54
u/l
—
9
68
21
242
0.86
0.23
1.3
1.1
0.71
0.68
ratio
—
6
23
42
460
0.90
0.22
1.4
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
9.69
—
0
12
0
13
0.00
0.21
0.0
1.2
—
66.31
—
0
13
0
14
0.00
0.20
0.0
1.9
—
2.36
—
0
14
0
14
0.00
0.20
0.0
2.2
—
—
—
0
0
6
51
1.18
0.19
2.3
3.3
1.32
2.92
nmol/l
—
6
51
26
288
0.90
0.17
1.9
2.1
5.78
6.08
ph
1.17
16
177
5
70
0.71
0.17
1.0
1.1
—
—
—
0
0
401
3975
1.07
0.16
6.6
4.9
4.61
4.66
mmol/l
0.49
384
3788
22
245
0.89
0.16
12.0
13.4
16.08
16.21
%
0.06
22
235
15
130
1.16
0.16
1.2
2.3
11.14
11.46
mg/l
0.10
15
124
15
170
0.88
0.14
3.3
3.6
—
—
—
0
0
382
3786
1.06
0.13
5.5
4.1
1.41
1.38
mmol/l
0.36
355
3581
166
1701
0.96
0.13
11.0
11.8
1.21
1.19
inr
0.17
126
1412
14
125
1.12
0.10
1.6
1.8
—
—
—
0
0
12
135
0.89
0.10
4.5
2.3
25.27
24.90
mmol/l
0.13
12
135
15
166
0.90
0.10
1.1
1.1
—
—
—
0
0
394
3964
0.95
0.09
6.7
4.8
1.30
1.36
mmol/l
2.40
374
3759
5
46
1.09
0.09
1.0
1.3
—
—
—
0
0
64
617
1.04
0.09
1.2
1.3
13.17
7.31
u/ml
0.23
32
262
5
61
0.82
0.08
2.2
2.7
—
—
—
0
0
7
65
1.08
0.08
2.6
1.5
—
—
—
0
0
6
70
0.86
0.07
1.0
1.1
—
—
—
0
0
6
70
0.86
0.07
1.7
3.1
6.35
8.44
pmol/l
—
6
70
6
72
0.83
0.07
1.8
1.3
—
—
—
0
0
275
2723
1.03
0.07
3.6
3.8
—
0.17
—
0
6
27
286
0.94
0.07
3.8
3.4
—
—
—
0
0
30
285
1.06
0.06
4.0
4.8
7.39
7.34
ph
1.68
19
221
48
496
0.96
0.06
1.6
1.6
1045.00
1212.27
nmol/l
0.75
35
394
186
1839
1.02
0.05
4.7
4.1
2.91
1.75
ug/l
0.69
173
1695
43
443
0.97
0.04
2.0
1.8
3.43
3.55
mmol/l
0.26
31
314
108
1066
1.02
0.03
3.8
3.4
0.00
0.01
estimate
0.69
26
376
16
151
1.06
0.03
1.3
1.6
—
—
—
0
0
69
678
1.02
0.03
1.4
1.7
418.30
19763947.82
pmol/l
0.50
60
592
11
102
1.08
0.03
1.1
2.7
1.07
1.74
ratio
—
6
56
25
259
0.96
0.02
2.6
3.2
120.92
133.08
g/l
1.15
25
250
40
409
0.98
0.02
10.4
11.9
124.77
124.99
g/l
0.02
40
399
21
202
1.04
0.02
1.1
1.6
—
—
—
0
0
12
127
0.94
0.01
2.3
2.7
—
—
—
0
0
127
1261
1.01
0.01
3.0
2.9
63.30
64.86
u/l
0.07
117
1193
25
257
0.97
0.01
3.4
3.3
5.10
5.14
kpa
0.10
25
251
50
493
1.02
0.01
1.1
1.3
—
—
—
0
0
69
683
1.01
0.01
1.5
1.3
39.99
27.11
iu/ml
0.41
20
198
25
246
1.02
0.00
3.4
3.4
7.40
7.42
ph
0.64
19
206
30
304
0.99
0.00
3.1
2.4
0.80
0.18
e6/l
1.02
25
291
15
151
0.99
0.00
1.9
2.2
—
—
—
0
0
404
4043
0.99
0.00
13.3
12.5
—
—
—
0
0
305
3047
1.00
0.00
3.3
3.5
47.18
50.68
u/l
0.35
290
2922
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
9
90
1.00
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
1.04
—
0
5
0
5
0.00
0.00
0.0
1.2
—
60.00
—
0
5
0
7
0.00
0.00
0.0
1.3
—
2.13
—
0
7
0
5
0.00
0.00
0.0
1.8
—
402.00
—
0
5
5
51
0.98
0.00
1.2
1.2
1.33
1.61
nmol/l
—
5
46
0
5
0.00
0.00
0.0
2.8
—
206.60
—
0
5
0
5
0.00
0.00
0.0
5.8
—
—
—
0
0
97
970
1.00
-0.00
5.2
5.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
70.00
—
0
8
0
8
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
0.41
—
0
9
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.7
—
7.22
—
0
9
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
1.21
—
0
8
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
-0.00
3.0
2.3
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_EARLY_SYPHILIS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
AB1_EARLY_SYPHILIS 1.498 [1.19, 1.88] < 0.001
Birth year 0.983 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 997 males with AB1_EARLY_SYPHILIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_EARLY_SYPHILIS.

N-year risk Females Males
1 No data 0.299%
5 No data 1.658%
10 No data 4.176%
15 No data 7.743%
20 No data 12.609%

Relationships between endpoints

↥

Index endpoint: AB1_EARLY_SYPHILIS – Early syphilis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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