No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
481 |
4. Check minimum number of eventsNone |
481 |
5. Include endpointsNone |
481 |
6. Filter based on genotype QC (FinnGen only) |
413 |
Control definitions (FinnGen only)
- Control exclude
- AB1_SEXUAL_TRANSMISSION
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Early syphilis
based on the number of shared cases.
Similar with more cases:
- Early syphilis, including avohilmo
- Syphilis, including avohilmo
- Syphilis
- Infections with a predominantly sexual mode of transmission
- Infections with a predominantly sexual mode of transmission, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2515 | 815 | 1643 |
| Only index persons | 2222 | 742 | 1480 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.02 | 0.05 |
| Only index persons | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 36.88 | 33.67 | 38.63 |
| Only index persons | 36.48 | 32.83 | 38.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 413 | 109 | 304 |
| Unadjusted period prevalence (%) | 0.11 | 0.04 | 0.14 |
| Median age at first event (years) | 39.47 | 32.21 | 42.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 455
- Matched controls
- 4550
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
31.3
287.9
225
138
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
153.6
230.9
115
10
A51.0
ICD-10 Finland
Primary genital syphilis
+∞
201.5
178
*
WW200
NOMESCO Finland
Immunization
29.6
157.7
111
49
A51.3
ICD-10 Finland
Secondary syphilis of skin and mucous membranes
+∞
156.5
141
*
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
66.0
154.3
86
16
A56.3
ICD-10 Finland
Chlamydial infection of anus and rectum
1478.4
120.6
112
*
A63.0
ICD-10 Finland
Anogenital (venereal) warts
37.4
110.2
70
22
A54.6
ICD-10 Finland
Gonococcal infection of anus and rectum
+∞
100.9
93
*
Y25
ICPC
Fear sexually transm disease male
11.6
91.6
106
116
A51.9
ICD-10 Finland
Early syphilis, unspecified
+∞
89.6
83
*
A54.5
ICD-10 Finland
Gonococcal pharyngitis
994.8
86.6
82
*
A54.0
ICD-10 Finland
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
+∞
68.5
64
*
Z29.2
ICD-10 Finland
Other prophylactic chemotherapy
132.6
55.2
58
5
Z21
ICD-10 Finland
Asymptomatic human immunodeficiency virus [HIV] infection status
199.4
52.1
53
*
A53.9
ICD-10 Finland
Syphilis, unspecified
+∞
49.9
47
*
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
87.0
49.1
54
7
09100
ICD-8 Finland
Early syphilis, symptomatic, Primary syphilis, except extragenital chancre
+∞
43.4
41
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
5.0
34.7
84
196
A56.4
ICD-10 Finland
Chlamydial infection of pharynx
+∞
27.4
26
*
A51.5
ICD-10 Finland
Early syphilis, latent
+∞
26.3
25
*
Z3231
NOMESCO Finland
Registered nurse
2.9
24.3
161
723
0913A
ICD-9 Finland
Early syphilis, symptomatic, Secondary syphilis of skin or mucous membranes
+∞
24.2
23
*
Y71
ICPC
Gonorrhoea male
+∞
23.1
22
*
Y70
ICPC
Syphilis male
+∞
22.1
21
*
Z25.1
ICD-10 Finland
Need for immunization against influenza
5.2
21.8
47
98
Z2221
NOMESCO Finland
Medical doctor
2.8
21.3
150
689
A60.0
ICD-10 Finland
Herpesviral infection of genitalia and urogenital tract
19.0
21.2
32
18
09120
ICD-8 Finland
Early syphilis, symptomatic, Secondary syphilis of skin and mucous membranes
+∞
21.0
20
*
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
109.9
19.7
21
*
Z20.2
ICD-10 Finland
Contact with and exposure to infections with a predominantly sexual mode of transmission
6.4
18.8
32
53
D06BB04
ATC
podophyllotoxin; topical
4.5
17.7
46
112
B23.0
ICD-10 Finland
Acute HIV infection syndrome
+∞
16.8
16
*
J01MA02
ATC
ciprofloxacin; systemic
2.3
16.6
196
1121
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
4.9
16.4
37
80
ZX114
NOMESCO Finland
Intramuscular
13.6
15.9
27
21
A55
ICD-10 Finland
Chlamydial lymphogranuloma (venereum)
+∞
15.7
15
*
A51.4
ICD-10 Finland
Other secondary syphilis
+∞
15.7
15
*
J05AB11
ATC
valaciclovir; oral
2.8
15.5
91
374
D11
ICPC
Diarrhoea
2.9
15.3
84
333
EB1AA, ,
SPAT
3.7
14.9
49
142
Y99
ICPC
Genital disease male other
23.2
14.3
20
9
ULA02
NOMESCO Finland
Kolposcopy
4.3
13.5
36
89
TAB00
NOMESCO Finland
Lumbar puncture
3.9
12.8
39
107
WX110, ,
SPAT
3.6
12.5
43
128
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.1
11.8
143
805
A52.1
ICD-10 Finland
Symptomatic neurosyphilis
+∞
11.5
11
*
J05AB01
ATC
aciclovir; systemic
2.3
11.4
105
528
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
11.4
110
565
Z71.8
ICD-10 Finland
Other specified counselling
2.0
11.2
171
1046
EB1SA, ,
SPAT
3.6
11.1
38
113
A54.9
ICD-10 Finland
Gonococcal infection, unspecified
+∞
10.5
10
*
A52.9
ICD-10 Finland
Late syphilis, unspecified
+∞
10.5
10
*
WNF00
NOMESCO Finland
Infection source and contact determination
33.4
10.4
13
*
WX290, ,
SPAT
4.3
10.3
27
66
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
4.6
10.1
24
54
Z20.6
ICD-10 Finland
Contact with and exposure to human immunodeficiency virus [HIV]
26.7
9.9
13
5
A97
ICPC
No disease
2.2
9.8
101
530
J01AA02
ATC
doxycycline; systemic
2.0
9.7
346
2765
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
11.7
9.6
17
15
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
2.9
9.4
45
164
J01FA10
ATC
azithromycin; systemic
1.9
9.4
271
2009
J01DB01
ATC
cefalexin; oral
2.3
9.2
387
3247
I84
ICD-10 Finland
Hemorrhoids
4.9
9.1
20
42
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.9
8.9
138
836
F43.29
ICD-10 Finland
Adaptation disorder UNS
4.7
8.7
20
44
U07
ICPC
Urine symptom/complaint other
2.9
8.6
40
144
A56.2
ICD-10 Finland
Chlamydial infection of genitourinary tract, unspecified
28.1
8.5
11
*
N48.1
ICD-10 Finland
Balanoposthitis
3.4
8.5
31
96
A53.0
ICD-10 Finland
Latent syphilis, unspecified as early or late
+∞
8.4
8
*
0910A
ICD-9 Finland
Early syphilis, symptomatic, Genital syphilis (primary)
+∞
8.4
8
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
8.0
99
552
EMB10
NOMESCO Finland
Tonsillectomy
3.0
8.0
36
127
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
1.9
7.7
111
652
B17.1
ICD-10 Finland
Acute hepatitis C
25.5
7.6
10
*
LDA10
NOMESCO Finland
Curettage of cervix uteri
7.0
7.4
17
25
A03.1
ICD-10 Finland
Shigellosis due to Shigella flexneri
+∞
7.3
7
*
A03.3
ICD-10 Finland
Shigellosis due to Shigella sonnei
+∞
7.3
7
*
A51.1
ICD-10 Finland
Primary anal syphilis
+∞
7.3
7
*
LEB00
NOMESCO Finland
Biopsy of vagina
9.0
7.1
14
16
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.1
7.1
29
97
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.1
7.0
68
346
J35.0
ICD-10 Finland
Chronic tonsillitis
3.0
6.9
31
109
B37.4
ICD-10 Finland
Candidiasis of other urogenital sites
17.0
6.8
10
6
R83
ICPC
Respiratory infection other
1.8
6.7
136
887
N48.8
ICD-10 Finland
Other specified disorders of penis
8.9
6.6
13
15
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.5
6.6
41
172
N05BA04
ATC
oxazepam; oral
1.8
6.5
111
687
N06AX11
ATC
mirtazapine; oral
1.7
6.4
155
1058
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
6.7
6.4
15
23
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.4
6.3
42
182
D06AX01
ATC
fusidic acid; topical
2.3
6.3
49
228
A52.3
ICD-10 Finland
Neurosyphilis, unspecified
+∞
6.3
6
*
A52.8
ICD-10 Finland
Late syphilis, latent
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
216
181
21.82
232.99
13.7
1.7
—
—
—
0
0
127
25
70.08
227.97
17.5
8.7
1474.22
111.25
u/ml
—
74
8
219
210
19.18
217.44
14.0
1.8
—
—
—
0
0
173
133
20.37
193.02
6.5
3.9
143.27
351.56
mg/l
1.31
151
64
105
28
48.45
174.86
2.8
3.1
28.30
40.70
%
2.30
15
15
144
5
419.62
151.51
4.3
1.8
—
—
—
0
0
230
511
8.08
110.86
10.7
1.9
—
—
—
0
0
237
560
7.75
106.96
11.7
1.9
—
—
—
0
0
146
379
5.20
54.74
2.2
3.1
32.21
43.73
u/l
0.47
141
325
45
45
10.99
40.44
1.1
1.1
—
—
—
0
0
67
141
5.40
31.02
1.3
1.5
235.37
226.07
miu/ml
0.05
22
74
38
54
7.59
25.83
1.1
1.1
—
—
—
0
0
143
617
2.92
23.07
2.2
2.9
0.83
0.86
e6/l
0.04
53
320
334
2211
2.92
23.02
13.5
10.2
3.72
4.15
e9/l
3.03
298
1934
131
574
2.80
20.21
2.2
3.0
2.61
1.16
e6/l
0.46
41
276
61
167
4.06
20.17
1.7
1.4
—
—
—
0
0
187
1012
2.44
18.36
2.7
3.1
0.23
0.34
e6/l
0.77
114
736
255
1585
2.39
18.23
5.3
5.5
37.79
36.58
g/l
2.60
241
1511
301
2039
2.41
17.29
7.8
7.0
13.43
12.26
umol/l
0.43
293
1949
47
122
4.18
16.63
2.8
1.5
—
—
—
0
0
201
1172
2.28
16.13
2.9
3.2
17.56
101.87
e6/l
0.88
130
895
27
44
6.46
16.11
2.3
1.7
—
—
—
0
0
262
1725
2.22
15.35
15.5
11.0
0.00
0.00
e9/l
0.47
221
1412
286
1991
2.18
14.04
4.1
3.3
0.00
0.00
estimate
-0.00
30
404
287
2012
2.15
13.69
4.1
3.3
0.00
3.97
estimate
0.50
30
409
287
2018
2.14
13.50
4.2
3.3
0.00
0.03
estimate
1.06
27
362
226
1480
2.05
12.55
11.1
3.4
37.19
35.74
u/l
0.08
217
1411
367
2887
2.40
12.50
9.8
8.7
76.99
78.40
u/l
0.29
361
2770
233
1694
1.77
8.16
2.2
1.9
1.42
1.49
mmol/l
0.65
220
1479
423
3752
2.81
7.87
18.6
13.5
89.74
87.48
ml/min/173m2
1.57
387
3486
429
3853
2.98
7.39
15.6
14.7
26.16
24.05
mg/l
0.68
375
3121
44
183
2.55
7.18
1.9
1.3
—
—
—
0
0
27
92
3.06
6.38
1.4
1.1
—
—
—
0
0
27
93
3.02
6.27
1.4
1.1
—
—
—
0
0
25
87
2.98
5.71
2.3
3.6
2.33
2.81
index
—
6
58
57
300
2.03
5.36
3.0
2.8
74.30
72.50
ml/min/173m2
0.14
30
133
179
1342
1.55
4.77
3.2
3.7
8.92
8.71
mmol/l
0.18
158
1165
13
26
5.11
4.66
3.6
2.5
—
—
—
0
0
8
8
10.15
4.53
1.1
1.1
—
—
—
0
0
32
145
2.30
4.39
2.2
3.1
1.11
1.34
mg/l
2.16
27
134
45
235
2.02
4.34
2.8
3.4
23.71
24.37
mmol/l
0.58
45
235
104
700
1.63
4.33
2.5
2.5
15.62
14.58
nmol/l
0.64
99
661
123
871
1.56
4.13
2.3
2.5
—
—
—
0
0
112
785
1.57
3.91
1.9
1.5
—
—
—
0
0
113
800
1.55
3.76
2.6
2.5
3.79
4.19
e6/l
0.21
104
732
54
316
1.80
3.72
2.0
2.0
39.72
36.72
nmol/l
0.40
54
308
320
2790
1.50
3.71
4.5
4.1
10.72
10.05
mm/h
0.40
314
2635
23
97
2.44
3.71
1.9
1.4
26.60
24.50
e6/l
0.04
15
70
14
40
3.58
3.63
1.3
2.3
—
—
—
0
0
8
13
6.24
3.51
4.8
2.2
—
—
—
0
0
23
100
2.37
3.49
1.9
1.5
537.87
990.45
e6/l
0.22
15
73
47
269
1.83
3.49
1.7
1.7
0.23
0.35
mg/l
1.26
26
135
126
935
1.48
3.32
1.7
1.6
20.41
19.75
nmol/l
0.22
114
809
438
4164
2.39
3.26
24.6
18.0
79.09
80.51
umol/l
0.70
438
4135
15
55
2.79
3.18
1.1
1.1
1.83
1.20
eliau/ml
—
6
24
88
624
1.51
2.87
3.0
3.0
2.43
2.44
mmol/l
0.21
75
558
189
1546
1.38
2.83
6.6
7.6
1.20
1.21
mmol/l
0.62
177
1460
11
34
3.29
2.74
1.0
1.1
—
—
—
0
0
396
3684
1.58
2.74
6.3
4.7
5.98
5.96
mmol/l
0.09
377
3470
14
54
2.64
2.73
1.4
1.5
196.17
166.12
pmol/l
0.71
14
54
10
29
3.50
2.70
1.2
1.1
—
—
—
0
0
397
3698
1.58
2.70
7.2
5.8
37.94
39.03
mmol/mol
0.47
387
3543
43
266
1.68
2.49
1.8
2.0
237.16
222.14
pmol/l
0.42
43
254
89
1180
0.69
2.46
3.0
2.7
0.00
0.00
estimate
0.50
23
324
21
103
2.09
2.45
1.3
1.4
—
—
—
0
0
178
1470
1.35
2.42
2.2
2.0
97.15
95.96
pmol/l
0.13
108
799
26
142
1.88
2.28
1.3
1.6
0.03
0.06
iu/ml
—
10
24
20
100
2.05
2.24
2.7
1.6
—
—
—
0
0
34
204
1.72
2.21
1.0
1.1
—
—
—
0
0
410
3883
1.57
2.17
16.8
16.9
3.94
3.99
mmol/l
2.99
402
3821
13
55
2.40
2.14
2.5
1.7
—
—
—
0
0
184
1552
1.31
2.10
2.5
2.5
77.06
73.90
nmol/l
0.74
170
1432
142
1159
1.33
2.04
3.3
3.6
2.36
2.35
mmol/l
0.35
128
1069
12
51
2.39
1.96
1.6
1.1
—
—
—
0
0
105
825
1.35
1.93
2.3
2.1
2.82
2.79
mg/l
0.05
92
722
19
99
1.96
1.93
1.0
1.2
—
—
—
0
0
29
177
1.68
1.81
1.5
1.5
6.30
6.16
u/l
0.03
21
148
9
35
2.60
1.81
1.2
1.2
—
—
—
0
0
6
18
3.36
1.75
1.2
1.0
—
—
—
0
0
298
2716
1.28
1.74
3.8
3.1
—
—
—
0
0
50
355
1.46
1.65
2.0
2.7
0.22
0.22
g/l
0.13
45
332
192
1676
1.25
1.56
2.8
2.8
144.66
153.19
ug/l
0.20
184
1599
14
71
2.00
1.55
2.4
1.9
—
—
—
0
0
23
138
1.70
1.55
2.2
2.8
—
—
—
0
0
12
58
2.10
1.50
1.3
1.4
—
—
—
0
0
12
58
2.10
1.50
1.3
1.4
—
—
—
0
0
38
263
1.49
1.44
1.7
1.6
—
—
—
0
0
49
357
1.42
1.43
4.0
3.1
—
—
—
0
0
5
17
2.96
1.36
1.0
1.0
—
—
—
0
0
91
737
1.29
1.36
3.2
3.5
1393.62
727.50
ng/l
0.21
66
540
441
4307
1.78
1.32
27.1
21.5
250.84
245.46
e9/l
0.97
433
4248
88
714
1.29
1.30
1.8
2.1
1.56
1.49
%
0.30
76
649
300
2784
1.23
1.28
3.7
3.7
14.66
14.68
pmol/l
0.04
282
2581
8
36
2.24
1.25
1.1
1.1
274.13
261.00
mg/l
—
8
28
6
25
2.42
1.24
1.7
3.4
966.00
736.84
u/ml
—
6
25
441
4313
1.73
1.22
27.1
21.4
4.59
4.69
e12/l
4.21
428
4246
195
1742
1.21
1.20
6.5
8.3
1.20
1.21
mmol/l
0.19
170
1545
57
443
1.33
1.15
2.1
1.8
—
—
—
0
0
0
35
0.00
1.15
0.0
1.6
—
49.46
—
0
35
5
20
2.52
1.15
1.0
1.3
49.20
21.14
u/l
—
5
14
55
427
1.33
1.12
2.1
1.8
—
—
—
0
0
120
1028
1.23
1.12
2.6
2.7
355.85
361.99
umol/l
0.32
112
932
14
81
1.75
1.10
2.1
1.6
—
—
—
0
0
5
21
2.40
1.09
1.0
1.2
192.00
92.53
u/l
—
5
15
5
21
2.40
1.09
2.6
2.6
0.30
1.10
%
—
5
21
106
900
1.23
1.07
3.2
3.4
1.02
1.02
kg/l
1.33
49
581
69
558
1.28
1.06
8.2
8.7
104.64
104.02
mmol/l
0.64
69
558
5
22
2.29
1.03
1.2
1.1
656.08
161.98
iu/ml
—
5
22
17
107
1.61
1.01
1.0
1.2
329.67
266.91
u/ml
0.42
12
65
49
381
1.32
1.01
3.3
3.6
0.61
1.83
mmol/l
1.04
44
325
7
35
2.02
1.00
1.1
1.1
—
—
—
0
0
58
463
1.29
0.99
8.2
11.1
0.35
0.98
mmol/l
0.65
50
399
9
49
1.85
0.99
1.2
1.2
—
—
—
0
0
5
23
2.19
0.98
2.6
3.7
89.40
132.17
nmol/l
—
5
23
15
92
1.65
0.98
2.7
1.5
—
—
—
0
0
12
69
1.76
0.97
1.2
1.3
—
—
—
0
0
186
1681
1.18
0.96
3.0
2.8
—
—
estimate
—
0
0
30
219
1.40
0.92
1.2
1.2
24.21
85.71
u/ml
—
8
88
8
42
1.92
0.89
3.4
4.1
—
—
—
0
0
6
30
2.01
0.87
1.7
1.0
—
—
—
0
0
6
30
2.01
0.87
1.7
1.0
—
—
—
0
0
8
44
1.83
0.86
1.5
1.2
—
—
—
0
0
104
903
1.20
0.85
1.4
1.3
1.05
1.34
u/ml
0.28
25
280
27
197
1.39
0.84
1.7
1.6
—
—
—
0
0
11
65
1.71
0.83
1.2
1.0
0.07
0.43
u/ml
—
5
21
6
32
1.89
0.82
1.5
1.5
16100.00
31021.06
e6/l
—
6
16
13
82
1.60
0.79
2.6
1.5
—
—
—
0
0
0
26
0.00
0.78
0.0
1.8
—
2.47
—
0
19
19
133
1.45
0.75
1.2
1.2
—
—
—
0
0
9
56
1.62
0.72
2.9
1.5
—
—
—
0
0
100
878
1.18
0.72
1.8
1.8
1.17
1.22
mg/l
0.08
74
679
5
26
1.93
0.71
1.2
1.2
—
—
—
0
0
16
110
1.47
0.69
2.2
1.7
—
—
—
0
0
69
591
1.20
0.66
2.1
1.9
—
—
—
0
0
136
1495
0.87
0.66
3.3
3.4
22.34
34.48
ng/l
1.54
81
990
21
155
1.37
0.64
1.6
2.3
132.40
594.27
ug/l
0.97
21
149
5
29
1.73
0.64
1.8
1.5
—
12.20
—
0
5
13
87
1.51
0.64
2.8
3.6
—
3535.88
—
0
8
12
176
0.67
0.63
4.3
3.4
24.88
24.83
mmol/l
0.03
12
169
8
53
1.52
0.58
1.1
1.3
—
—
—
0
0
12
81
1.49
0.57
1.2
1.1
—
1.87
—
0
6
6
36
1.68
0.57
1.3
1.2
—
—
—
0
0
6
36
1.68
0.57
1.3
1.1
—
—
—
0
0
6
37
1.63
0.55
1.3
1.2
—
—
—
0
0
6
37
1.63
0.55
1.3
1.2
—
—
—
0
0
21
161
1.32
0.52
1.5
1.9
1.80
5.58
iu/ml
—
5
35
14
100
1.41
0.52
2.6
1.6
—
—
—
0
0
6
41
1.47
0.50
1.3
1.1
—
—
—
0
0
131
1206
1.12
0.50
3.8
4.4
14.11
9.86
mg/mmol
0.25
82
797
15
199
0.75
0.47
1.3
1.6
—
—
—
0
0
354
3443
1.13
0.47
4.8
4.5
1.80
1.87
mu/l
0.66
338
3221
15
112
1.35
0.45
7.7
6.2
—
467.73
—
0
15
27
220
1.24
0.45
2.6
2.5
0.66
0.66
%
0.01
27
220
14
104
1.36
0.43
1.0
1.3
—
—
—
0
0
5
31
1.62
0.43
2.0
2.8
—
—
—
0
0
25
203
1.24
0.43
1.3
1.4
—
—
—
0
0
5
33
1.52
0.41
1.4
1.3
32.40
44.32
u/l
—
5
27
0
15
0.00
0.41
0.0
1.7
—
43.25
—
0
15
0
16
0.00
0.41
0.0
2.1
—
119.66
—
0
16
0
17
0.00
0.40
0.0
4.7
—
76.34
—
0
17
27
223
1.22
0.40
2.6
2.6
1.25
1.38
%
0.34
27
223
5
34
1.48
0.40
2.0
1.2
102.40
107.94
pmol/l
—
5
34
0
18
0.00
0.40
0.0
1.0
—
0.37
—
0
18
13
97
1.35
0.40
1.3
1.1
3.37
2.72
u/ml
—
8
54
54
477
1.15
0.39
2.1
3.0
12.05
9.09
umol/l
0.32
46
432
5
35
1.43
0.39
1.0
1.5
—
—
—
0
0
9
71
1.27
0.36
1.6
1.6
—
—
—
0
0
5
79
0.63
0.36
1.8
1.3
—
—
—
0
0
17
211
0.80
0.35
2.5
3.3
1.38
1.83
mmol/l
0.19
12
158
11
83
1.33
0.32
2.5
2.2
147.17
133.25
g/l
—
6
59
12
92
1.31
0.32
3.0
2.1
8.78
8.29
kpa
0.68
12
92
7
56
1.25
0.29
1.3
1.1
—
—
—
0
0
27
311
0.86
0.28
1.9
2.3
6.94
9.33
ug/l
0.60
22
283
14
113
1.25
0.27
2.3
1.8
—
—
—
0
0
119
1126
1.08
0.26
2.7
2.7
0.59
0.70
ug/l
0.94
77
583
151
1579
0.93
0.26
3.4
3.1
0.00
0.01
estimate
0.74
23
338
406
4012
1.11
0.26
7.3
5.3
2.80
2.80
mmol/l
0.02
389
3812
10
127
0.78
0.26
1.5
1.7
—
—
—
0
0
35
392
0.88
0.25
4.8
4.5
27.87
29.77
%
0.39
23
278
9
76
1.19
0.24
1.1
1.2
16.69
16.54
u/l
—
9
68
34
379
0.89
0.23
4.7
7.0
—
—
—
0
0
139
1452
0.94
0.23
3.3
3.6
22.47
21.65
%
0.19
50
545
21
242
0.86
0.23
1.3
1.1
0.71
0.68
ratio
—
6
23
0
11
0.00
0.21
0.0
1.2
—
0.45
—
0
6
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
11
0.00
0.21
0.0
1.1
—
108.55
—
0
11
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
4.1
—
4.76
—
0
14
0
14
0.00
0.20
0.0
4.1
—
10.09
—
0
14
6
51
1.18
0.19
2.3
3.3
1.32
2.92
nmol/l
—
6
51
401
3975
1.07
0.16
6.6
4.9
4.61
4.66
mmol/l
0.49
384
3788
22
245
0.89
0.16
12.0
13.4
16.08
16.21
%
0.06
22
235
15
130
1.16
0.16
1.2
2.3
11.14
11.46
mg/l
0.10
15
124
31
284
1.10
0.15
1.4
1.5
—
—
—
0
0
9
79
1.14
0.15
2.4
1.7
—
—
—
0
0
10
84
1.19
0.14
1.0
1.1
—
22.51
—
0
18
10
84
1.19
0.14
1.6
1.6
—
—
—
0
0
382
3786
1.06
0.13
5.5
4.1
1.41
1.38
mmol/l
0.36
355
3581
18
201
0.89
0.13
3.9
3.6
44.39
50.74
%
0.48
18
196
166
1701
0.96
0.13
11.0
11.8
1.21
1.19
inr
0.17
126
1412
57
599
0.94
0.12
2.5
2.1
4.25
3.74
ratio
0.94
46
476
12
135
0.89
0.10
4.5
2.3
25.27
24.90
mmol/l
0.13
12
135
394
3964
0.95
0.09
6.7
4.8
1.30
1.36
mmol/l
2.40
374
3759
64
617
1.04
0.09
1.2
1.3
13.17
7.31
u/ml
0.23
32
262
6
56
1.07
0.08
1.3
1.4
—
—
—
0
0
27
287
0.94
0.08
1.9
1.4
—
—
—
0
0
7
64
1.10
0.08
1.0
1.1
—
—
—
0
0
7
65
1.08
0.08
1.4
1.5
—
—
—
0
0
6
70
0.86
0.07
1.7
3.1
6.35
8.44
pmol/l
—
6
70
7
81
0.86
0.07
1.4
1.2
—
—
—
0
0
48
496
0.96
0.06
1.6
1.6
1045.00
1212.27
nmol/l
0.75
35
394
12
131
0.91
0.05
1.5
2.0
—
—
—
0
0
186
1839
1.02
0.05
4.7
4.1
2.91
1.75
ug/l
0.69
173
1695
97
988
0.98
0.05
2.8
3.2
1012.54
966.76
ng/l
0.07
82
822
43
443
0.97
0.04
2.0
1.8
3.43
3.55
mmol/l
0.26
31
314
108
1066
1.02
0.03
3.8
3.4
0.00
0.01
estimate
0.69
26
376
69
678
1.02
0.03
1.4
1.7
418.30
19763947.82
pmol/l
0.50
60
592
11
102
1.08
0.03
1.1
2.7
1.07
1.74
ratio
—
6
56
25
259
0.96
0.02
2.6
3.2
120.92
133.08
g/l
1.15
25
250
40
409
0.98
0.02
10.4
11.9
124.77
124.99
g/l
0.02
40
399
127
1261
1.01
0.01
3.0
2.9
63.30
64.86
u/l
0.07
117
1193
25
257
0.97
0.01
3.4
3.3
5.10
5.14
kpa
0.10
25
251
69
683
1.01
0.01
1.5
1.3
39.99
27.11
iu/ml
0.41
20
198
10
95
1.05
0.00
1.9
1.3
—
—
—
0
0
30
304
0.99
0.00
3.1
2.4
0.80
0.18
e6/l
1.02
25
291
305
3047
1.00
0.00
3.3
3.5
47.18
50.68
u/l
0.35
290
2922
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.2
1.2
1.33
1.61
nmol/l
—
5
46
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
0.40
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
5.98
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
1.20
—
0
9
0
8
0.00
-0.00
0.0
10.5
—
10.88
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
1.29
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
36.33
—
0
6
7
69
1.01
-0.00
1.6
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_EARLY_SYPHILIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_EARLY_SYPHILIS | 1.498 [1.19, 1.88] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 997 males with AB1_EARLY_SYPHILIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_EARLY_SYPHILIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.299% |
| 5 | No data | 1.658% |
| 10 | No data | 4.176% |
| 15 | No data | 7.743% |
| 20 | No data | 12.609% |
Relationships between endpoints
↥Index endpoint: AB1_EARLY_SYPHILIS – Early syphilis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data