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Problems related to education and literacy

Z21_PROBL_RELATED_EDUCATION_LITER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Z55
  • Cause of death: ICD-10 Z55

2 out of 7 registries used, show all original rules.

100

4. Check minimum number of events

None

100

5. Include endpoints

None

100

6. Filter based on genotype QC (FinnGen only)

85

Control definitions (FinnGen only)

Control exclude
Z21_PERSONS_W_POTEN_HEALTH_HAZARDS_RELATED_SOCIO_PSYCHOSO_CIRCUMSTANC

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z5[5-9]|Z6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 85 46 39
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 15.35 15.47 15.20

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
95
Matched controls
950
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z55.4
ICD-10 Finland
Educational maladjustment and discord with teachers and classmates
+∞
34.5
31
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
7.3
20.4
44
101
Z55.9
ICD-10 Finland
Problem related to education and literacy, unspecified
219.2
18.2
18
*
Z55.8
ICD-10 Finland
Other problems related to education and literacy
+∞
16.1
15
*
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
5.7
15.9
45
129
N06AB03
ATC
fluoxetine; oral
7.2
14.2
25
45
Z55.3
ICD-10 Finland
Underachievement in school
+∞
13.9
13
*
ZY010
NOMESCO Finland
Hospital outpatient
7.7
13.6
22
36
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
5.6
12.7
30
72
Z55.0
ICD-10 Finland
Illiteracy and low-level literacy
+∞
10.6
10
*
N05AH04
ATC
quetiapine; oral
4.2
10.4
40
140
N05AX12
ATC
aripiprazole; systemic
5.6
9.6
21
46
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
5.6
8.5
18
38
Z2446
NOMESCO Finland
Social worker
7.4
8.4
20
33
N06AB06
ATC
sertraline; oral
4.1
8.2
28
88
F93.89
ICD-10 Finland
Other childhood emotional disorders
16.9
8.0
12
8
P76
ICPC
Depressive disorder
4.4
7.9
23
64
N06AB04
ATC
citalopram; systemic
4.2
7.6
24
71
P19
ICPC
Drug abuse
24.6
6.8
9
*
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
9.8
6.8
13
15
EBA05
NOMESCO Finland
Complicated extraction of tooth
3.4
6.8
33
130
F92.0
ICD-10 Finland
Depressive conduct disorder
74.7
6.5
7
*
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
6.6
6.5
16
28
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
8.7
6.4
13
17
T36
ICD-10 Finland
Poisoning by systemic antibiotics
7.6
6.3
14
21
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
7.3
6.1
14
22
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.4
6.1
17
45

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
20
44
5.49
9.08
3.4
2.0
—
—
—
0
0
25
81
3.83
6.93
8.5
1.5
—
—
—
0
0
11
23
5.26
4.01
25.9
19.9
0.78
0.72
%
0.15
11
23
8
11
7.82
3.94
1.6
3.1
—
—
—
0
0
23
100
2.72
3.80
3.3
1.6
—
—
—
0
0
11
25
4.83
3.76
25.6
18.5
1.64
1.51
%
0.12
11
25
11
25
4.83
3.76
25.9
18.5
92.75
94.48
%
0.45
11
25
9
18
5.40
3.46
1.3
1.1
—
—
—
0
0
38
220
2.21
3.34
2.7
4.6
37.80
38.46
g/l
0.23
33
211
39
231
2.17
3.22
6.3
5.6
—
—
—
0
0
58
401
2.15
3.20
7.3
6.4
0.16
0.16
e9/l
0.06
48
355
56
385
2.11
3.10
6.5
5.9
0.04
0.04
e9/l
0.04
47
335
61
438
2.10
2.95
9.8
8.9
4.50
4.04
e9/l
0.69
53
384
14
53
2.93
2.94
2.8
1.4
0.21
0.37
mg/l
—
8
24
7
13
5.71
2.92
12.4
2.1
1.74
1.30
mmol/l
—
7
13
55
382
2.04
2.90
6.5
5.9
0.55
0.53
e9/l
0.28
47
335
13
48
2.98
2.85
22.5
20.9
7.41
7.42
ph
—
6
29
7
14
5.30
2.78
1.0
1.6
—
—
—
0
0
9
24
4.03
2.75
9.8
22.1
—
—
—
0
0
39
243
2.03
2.74
13.9
7.7
1.20
1.22
mmol/l
1.09
39
226
42
271
1.99
2.66
8.4
7.9
1.21
1.22
mmol/l
0.55
36
230
6
11
5.74
2.58
14.2
2.3
3.90
3.82
mmol/l
—
6
11
16
72
2.47
2.44
1.6
1.6
381.44
424.54
nmol/l
0.40
16
63
24
130
2.13
2.41
3.7
3.9
—
—
—
0
0
24
130
2.13
2.41
3.2
1.6
—
—
—
0
0
24
131
2.11
2.36
3.3
1.6
—
—
—
0
0
56
410
1.89
2.35
6.6
5.8
1.96
1.96
e9/l
0.00
47
367
11
41
2.90
2.30
25.6
14.0
—
—
—
0
0
7
19
3.89
2.19
1.0
1.2
353.57
329.89
mg/l
—
7
19
22
121
2.06
2.11
3.4
1.6
—
—
—
0
0
5
142
0.32
2.11
1.0
1.3
—
—
—
0
0
23
130
2.01
2.05
3.3
1.6
—
—
—
0
0
48
347
1.77
2.00
7.6
8.6
0.00
0.00
e9/l
0.45
38
283
55
423
1.71
1.77
3.6
3.3
0.00
0.00
estimate
-0.00
11
91
12
55
2.35
1.76
1.9
1.3
—
—
—
0
0
12
56
2.31
1.69
30.0
10.4
101.92
104.80
mmol/l
0.78
12
56
32
214
1.75
1.69
4.0
5.4
—
—
—
0
0
11
50
2.36
1.64
1.2
1.2
—
—
—
0
0
31
208
1.73
1.61
3.4
2.8
1.02
1.02
kg/l
0.04
19
133
6
20
3.13
1.61
24.7
5.1
37.13
36.92
°c
—
6
20
53
412
1.65
1.57
3.6
3.2
0.00
0.00
estimate
-0.00
12
97
45
337
1.64
1.54
3.2
2.8
6.27
6.18
ph
0.19
30
195
23
143
1.80
1.53
1.3
1.3
4.34
5.94
u/ml
—
10
59
53
415
1.63
1.51
3.6
3.3
0.00
0.00
estimate
-0.00
11
96
26
169
1.74
1.50
2.0
2.7
7.38
7.40
ph
0.62
20
119
9
39
2.44
1.47
5.1
10.1
9.97
6.85
mmol/l
—
9
39
31
213
1.68
1.46
1.9
2.5
17.41
44.52
e6/l
0.81
23
160
25
162
1.74
1.45
2.1
2.1
329.61
87.48
ug/g
0.95
18
123
34
240
1.65
1.45
3.6
3.5
0.00
0.01
estimate
0.49
12
91
35
249
1.64
1.45
1.5
1.6
81.99
95.18
pmol/l
1.72
17
132
44
332
1.61
1.44
3.4
3.0
0.00
0.01
estimate
—
8
83
75
646
1.76
1.43
3.7
3.6
36.43
36.03
mmol/mol
0.14
70
615
21
130
1.79
1.42
3.6
1.6
—
—
—
0
0
79
692
1.84
1.40
3.8
3.1
5.55
5.49
mmol/l
0.24
74
635
35
251
1.62
1.40
2.6
3.2
18.74
37.83
e6/l
0.53
26
172
60
494
1.58
1.31
4.2
3.9
—
23.88
—
0
8
5
18
2.87
1.30
1.0
1.2
3.32
3.47
mmol/l
—
5
18
28
194
1.63
1.27
3.2
2.1
—
—
—
0
0
27
186
1.63
1.25
1.7
2.4
0.11
0.20
e6/l
0.40
21
136
20
127
1.73
1.24
2.5
2.0
544.54
578.11
mosm/kgh2o
0.26
20
113
34
249
1.57
1.22
1.7
1.4
1.79
2.00
g/l
0.56
22
170
23
153
1.66
1.21
2.0
2.4
—
—
—
0
0
7
33
2.21
1.08
17.4
8.8
25.64
25.80
mmol/l
—
7
33
26
184
1.57
1.07
1.7
2.5
—
—
estimate
—
0
0
29
212
1.53
1.04
4.3
4.5
—
—
—
0
0
24
326
0.65
1.02
2.2
2.2
—
—
—
0
0
34
263
1.46
0.92
1.7
1.6
1.56
1.36
mmol/l
0.64
29
241
6
29
2.14
0.91
1.0
1.1
—
—
—
0
0
21
147
1.55
0.90
2.7
1.6
0.70
0.63
mg/l
0.13
16
105
24
319
0.67
0.90
2.5
1.7
—
—
—
0
0
86
804
1.73
0.88
16.2
10.2
26.05
21.70
mg/l
0.53
71
628
6
31
2.00
0.86
2.2
1.3
908.67
320.46
mu/l
—
6
26
15
98
1.63
0.84
4.1
3.0
36.00
107.13
ng/l
—
7
52
34
268
1.42
0.82
3.0
2.6
0.00
0.00
estimate
—
9
81
6
33
1.87
0.80
3.5
3.4
24.32
24.08
mmol/l
—
6
33
14
203
0.64
0.78
1.8
1.7
—
—
—
0
0
5
23
2.24
0.77
14.0
4.2
0.68
0.67
%
—
5
23
5
25
2.05
0.74
2.0
1.9
—
—
—
0
0
5
26
1.97
0.71
14.0
4.1
129.60
138.69
g/l
—
5
26
5
95
0.50
0.70
2.8
4.0
3.18
1.34
ug/l
—
5
87
23
296
0.71
0.70
1.8
2.0
—
—
—
0
0
25
193
1.40
0.67
1.7
1.6
—
—
—
0
0
12
79
1.59
0.66
1.4
2.7
—
—
—
0
0
30
363
0.75
0.61
3.4
2.7
—
—
estimate
—
0
0
79
736
1.44
0.60
3.5
3.3
4.63
4.58
mmol/l
0.17
73
710
79
736
1.44
0.60
3.6
3.4
2.80
2.78
mmol/l
0.08
71
707
19
246
0.72
0.59
2.8
2.0
—
—
—
0
0
9
59
1.58
0.57
1.1
1.1
—
—
—
0
0
6
37
1.66
0.57
1.2
1.4
—
—
—
0
0
9
60
1.55
0.56
3.0
1.8
—
—
—
0
0
21
163
1.37
0.54
3.4
3.3
—
—
—
0
0
10
69
1.50
0.46
1.1
1.8
—
—
—
0
0
8
57
1.44
0.43
1.6
1.6
2.11
1.87
%
—
8
51
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
57
528
1.20
0.33
4.4
3.8
—
—
—
0
0
77
734
1.26
0.32
3.3
3.2
1.27
1.40
mmol/l
2.25
70
706
8
62
1.32
0.29
1.0
1.2
—
—
—
0
0
71
675
1.21
0.28
2.9
3.0
1.49
1.22
mmol/l
1.04
64
651
23
264
0.83
0.27
2.2
1.7
—
—
—
0
0
5
37
1.37
0.24
1.4
3.1
1.19
1.22
mmol/l
—
5
31
32
289
1.16
0.23
1.5
1.4
0.41
2.49
u/ml
—
9
81
11
89
1.27
0.22
1.8
2.2
13.13
15.17
umol/l
0.52
11
81
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
0.47
—
0
10
0
13
0.00
0.21
0.0
3.0
—
—
—
0
0
9
79
1.15
0.16
1.2
1.2
—
—
—
0
0
10
86
1.18
0.11
2.3
3.2
—
—
—
0
0
11
96
1.16
0.11
1.8
1.3
—
—
—
0
0
31
328
0.92
0.10
1.8
1.8
—
—
—
0
0
5
45
1.12
0.10
1.2
1.0
0.84
0.84
g/l
—
5
45
5
45
1.12
0.10
1.2
1.0
1.60
1.50
g/l
—
5
45
13
116
1.14
0.10
2.4
2.6
1157.78
7106.02
u/l
—
5
54
10
113
0.87
0.09
1.6
2.2
—
—
—
0
0
6
56
1.08
0.09
4.5
3.4
5.20
4.56
pmol/l
—
6
50
7
63
1.12
0.08
1.4
1.4
—
—
—
0
0
21
196
1.09
0.08
6.1
2.9
13.55
17.40
ng/l
0.49
14
89
8
74
1.09
0.08
1.3
1.4
—
—
—
0
0
42
407
1.06
0.05
2.2
2.3
—
—
—
0
0
13
121
1.09
0.04
1.4
1.5
—
—
—
0
0
10
93
1.08
0.02
1.1
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
2301.40
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
199.63
—
0
7
0
7
0.00
0.00
0.0
5.4
—
14.04
—
0
7
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
0.00
—
0
5
0
5
0.00
0.00
0.0
1.0
—
32.00
—
0
5
0
7
0.00
0.00
0.0
1.9
—
11.57
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
6.29
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
1.23
—
0
8
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
1507.50
—
0
6
85
850
1.00
-0.00
14.9
9.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.85
-0.00
1.0
1.1
—
—
—
0
0
7
74
0.94
-0.00
1.6
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
65.33
—
0
6
5
49
1.02
-0.00
1.8
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Z21_PROBL_RELATED_EDUCATION_LITER – Problems related to education and literacy

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).