Vascular dementia (multiple infarctions)

VD_MI

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F01.1
  • Hospital discharge: ICD-9 4378
  • Cause of death: ICD-10 F01.1
  • Cause of death: ICD-9 4378

2 out of 7 registries used, show all original rules.

785

4. Check minimum number of events

None

785

5. Include endpoints

None

785

6. Filter based on genotype QC (FinnGen only)

677

Control definitions (FinnGen only)

Control exclude
F5_DEMENTIA, G6_ALZHEIMER, G6_AD_STRICT

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F01
Name in latin
Dementia e multis infarctibus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 677 205 472
Unadjusted period prevalence (%) 0.17 0.07 0.22
Median age at first event (years) 77.29 79.24 76.45

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
689
Matched controls
6880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
+∞
298.1
264
*
F03
ICD-10 Finland
Unspecified dementia
59.9
288.4
165
36
F01.1
ICD-10 Finland
Multi-infarct dementia
+∞
241.1
217
*
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
+∞
229.2
207
*
N06DX01
ATC
memantine; oral
65.9
199.7
111
20
F01.9
ICD-10 Finland
Vascular dementia, unspecified
272.2
168.4
166
8
N06DA02
ATC
donepezil; oral
58.8
146.6
83
16
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
7.5
141.4
280
578
G30.1
ICD-10 Finland
Alzheimer disease with late onset
83.9
140.7
75
10
N05AX08
ATC
risperidone; systemic
9.8
115.0
150
190
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
80.8
76
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
4.6
79.5
274
866
N05AH04
ATC
quetiapine; oral
6.3
79.0
154
299
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
629.0
59.6
58
*
4378A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Other[MULTI-INFARKTIDEMENTIA]
+∞
53.8
51
*
N06DA03
ATC
rivastigmine; oral, transdermal
121.5
52.6
56
5
F01.14
ICD-10 Finland
Multi-infarct dementia's other mixed symptoms of mixed type
+∞
49.6
47
*
F01.0
ICD-10 Finland
Vascular dementia of acute onset
+∞
48.5
46
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.9
46.5
114
266
R41.0
ICD-10 Finland
Disorientation, unspecified
7.4
45.7
70
104
G30.8
ICD-10 Finland
Other Alzheimer disease
87.7
44.5
49
6
N03AG01
ATC
valproic acid; systemic, rectal
7.7
43.8
64
90
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
77.9
39.4
44
6
4378X
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Other[MORBUS CERBROVASCULARIS ALIA DEFINITA]
+∞
38.9
37
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.9
37.3
129
388
P70
ICPC
Dementia
10.6
36.5
41
41
N05AD03
ATC
melperone; systemic
7.2
36.5
56
83
N06AB04
ATC
citalopram; systemic
3.1
36.3
194
768
N06DA04
ATC
galantamine; oral
100.3
35.1
38
*
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
68.6
34.3
39
6
Z75.5
ICD-10 Finland
Holiday relief care
8.9
33.8
43
51
N05AD01
ATC
haloperidol; systemic
5.2
33.2
73
154
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.6
32.0
64
124
B01AC07
ATC
dipyridamole; systemic
3.1
31.3
155
582
P20
ICPC
Memory disturbance
3.2
30.7
141
506
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.8
29.1
70
159
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.1
27.4
49
85
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.7
27.4
96
289
F01.11
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly paranoidism
+∞
27.3
26
*
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
50.3
24.4
29
6
N05AH03
ATC
olanzapine; systemic
7.0
23.1
36
54
R53
ICD-10 Finland
Malaise and fatigue
2.4
22.6
200
994
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
6.9
20.5
32
48
N03AF02
ATC
oxcarbazepine; oral
6.3
20.0
34
56
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
18.9
316
2002
F01
ICD-10 Finland
Vascular dementia
68.4
17.8
20
*
F01.13
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly depression
+∞
17.8
17
*
F01.12
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly hallucinations
+∞
17.8
17
*
F01.3
ICD-10 Finland
Mixed cortical and subcortical vascular dementia
184.3
17.6
18
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.7
17.2
106
440
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.9
16.9
52
142
2900A
ICD-9 Finland
Senile and presenile organic psychotic conditions, Senile dementia, uncomplicated
+∞
16.7
16
*
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
+∞
16.7
16
*
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
173.8
16.6
17
*
K90
ICPC
Stroke/cerebrovascular accident
4.2
16.1
44
110
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
7.1
15.8
24
35
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
+∞
15.7
15
*
A06AD11
ATC
lactulose; oral
2.0
14.7
194
1107
N05BA04
ATC
oxazepam; oral
2.1
14.7
180
1000
SPAT1053
SPAT
Memory test
2.3
14.6
128
622
F05.1
ICD-10 Finland
Delirium superimposed on dementia
27.8
14.3
19
7
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.2
14.2
39
98
N06AB10
ATC
escitalopram; oral
2.6
13.7
82
334
XA800
NOMESCO Finland
Neuropsychological investigation
6.6
13.7
22
34
H53.4
ICD-10 Finland
Visual field defects
4.9
13.6
30
63
F0019, G301,
ICD-10 Finland
+∞
13.6
13
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
13.3
252
1619
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.7
12.9
24
43
N05BA06
ATC
lorazepam; systemic, sublingual
3.1
12.8
56
192
Z2445
NOMESCO Finland
Psychologist
9.9
12.8
25
26
G30
ICD-10 Finland
Alzheimer disease
+∞
12.5
12
*
N06AX11
ATC
mirtazapine; oral
1.9
12.5
184
1085
F01.2
ICD-10 Finland
Subcortical vascular dementia
38.2
12.2
15
*
AA1AD
NOMESCO Finland
CT of head and brain
1.9
11.6
207
1294
F05.9
ICD-10 Finland
Delirium, unspecified
3.9
11.4
34
91
K91
ICPC
Cerebrovascular disease
5.7
11.2
21
38
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
11.0
138
765
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.0
11.0
51
181
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
2.8
11.0
58
221
A28
ICPC
Limited function/disability NOS
1.9
10.9
169
1008
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.0
10.8
48
166
TAB00
NOMESCO Finland
Lumbar puncture
5.1
10.6
22
44
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.9
10.5
50
180
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.8
10.4
52
193
F06.7
ICD-10 Finland
Mild cognitive disorder
3.7
10.0
32
90
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
9.9
131
738
S01.0
ICD-10 Finland
Open wound of scalp
2.5
9.6
65
280
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
3.1
9.6
41
139
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
2.9
9.3
44
158
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
3.5
9.1
31
91
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
4.3
9.0
23
55
A10AB05
ATC
insulin aspart; parenteral
2.5
8.9
59
252
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.0
8.8
38
130
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
8.7
177
1137
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.8
8.5
44
166
N05AB03
ATC
perphenazine; systemic, rectal
3.8
8.4
25
67
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
8.4
56
1157
F009, G309,
ICD-10 Finland
+∞
8.3
8
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
7.2
8.3
19
27
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
2.7
8.3
43
163
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.2
8.1
72
349
130
Kela drug reimbursment
Malignant tumour
0.2
8.0
13
549
315
Kela drug reimbursment
Clopidogrel
3.8
7.9
24
65
SPAT1229
SPAT
Assessment of need for aid
2.3
7.9
61
280
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.8
7.8
129
777
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
4.1
7.8
21
52
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.8
7.5
37
136
SPAT1101
SPAT
Orthostatic test
2.5
7.5
47
196
SPAT1216
SPAT
Assessment of functional ability
1.8
7.5
115
678
N05CD07
ATC
temazepam; oral
1.7
7.5
148
940
G30.0
ICD-10 Finland
Alzheimer disease with early onset
+∞
7.3
7
*
R41.3
ICD-10 Finland
Other amnesia
3.5
7.3
25
74
R55
ICD-10 Finland
Syncope and collapse
1.9
7.2
97
549
S06.0
ICD-10 Finland
Concussion
2.2
7.0
62
300
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
4.4
7.0
17
39
I69.8
ICD-10 Finland
Sequelae of other and unspecified cerebrovascular diseases
7.6
6.9
15
20
N30.0
ICD-10 Finland
Acute cystitis
1.9
6.8
92
519
4019X
ICD-9 Finland
Essential hypertension, Unspecified
2.1
6.8
62
304
I95.1
ICD-10 Finland
Orthostatic hypotension
2.3
6.8
49
218
F22.0
ICD-10 Finland
Delusional disorder
7.3
6.7
15
21
F01.30
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without additional symptoms
22.7
6.7
9
*
G04BD07
ATC
tolterodine; oral
2.2
6.6
54
253
N06AB06
ATC
sertraline; oral
2.5
6.6
41
170
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
4.0
6.5
18
46
F01.39
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without information on additional symptoms
70.4
6.4
7
*
N28
ICPC
Limited function/disability (N)
6.6
6.4
15
23
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.9
6.3
29
103
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
11.1
6.3
11
10
F01.24
ICD-10 Finland
Subcortical vascular dementia other additional symptoms of mixed type
+∞
6.3
6
*
A10AE04
ATC
insulin glargine; parenteral
2.0
6.2
69
365
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.2
6.2
52
247
S72.0
ICD-10 Finland
Fracture of neck of femur
2.1
6.2
61
309
I67.2
ICD-10 Finland
Cerebral atherosclerosis
7.8
6.1
13
17
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
10.1
6.0
11
11

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
143
900
1.74
7.45
2.0
1.8
1044.89
1177.13
nmol/l
1.06
115
682
55
1038
0.49
6.24
1.6
1.9
1.24
1.22
mmol/l
0.11
46
822
78
1312
0.54
6.14
1.8
2.5
—
—
—
0
0
17
34
5.09
5.90
1.3
1.1
—
—
—
0
0
224
2842
0.68
5.05
5.1
5.1
3.89
4.15
mmol/l
3.72
208
2532
223
2810
0.69
4.74
4.9
5.1
1.27
1.38
mmol/l
3.40
207
2464
237
2936
0.70
4.49
5.6
6.0
2.12
2.33
mmol/l
3.90
223
2595
168
1244
1.46
4.19
2.7
2.1
230.45
208.34
u/l
0.23
155
1163
242
2962
0.72
4.15
5.6
5.7
6.31
6.21
mmol/l
0.46
210
2592
105
1500
0.64
4.14
16.5
13.3
0.00
0.00
e9/l
0.42
84
1184
219
2706
0.72
3.91
4.5
4.4
1.23
1.23
mmol/l
0.05
200
2356
187
1430
1.42
3.90
4.4
4.0
—
—
—
0
0
62
967
0.60
3.55
2.9
3.5
0.83
0.92
ug/l
0.42
48
709
47
786
0.57
3.53
5.4
4.0
—
—
—
0
0
70
444
1.64
3.51
2.9
2.7
4.11
6.52
ug/l
1.82
57
382
88
1256
0.66
3.40
3.7
3.3
74.61
66.92
mg/l
0.14
67
870
70
1025
0.65
3.04
6.3
6.1
—
—
—
0
0
9
240
0.37
2.98
1.8
1.6
—
—
—
0
0
246
2900
0.76
2.91
8.3
7.5
45.31
41.49
mmol/mol
3.96
224
2610
277
3214
0.77
2.91
12.6
12.3
26.36
24.47
u/l
0.24
260
3070
92
1259
0.69
2.83
3.5
3.3
6.81
6.74
mmol/l
0.06
77
1034
21
420
0.48
2.83
1.3
1.2
63.78
41.19
iu/ml
—
6
143
133
1701
0.73
2.74
4.7
6.4
2.34
8.34
ug/l
1.61
111
1486
178
1442
1.31
2.46
5.3
4.6
—
—
—
0
0
28
486
0.56
2.43
1.4
1.5
—
—
—
0
0
276
3159
0.79
2.43
27.7
20.3
—
—
—
0
0
0
64
0.00
2.43
0.0
1.1
—
—
—
0
0
15
317
0.46
2.39
3.5
4.0
0.20
1.01
%
—
5
113
99
1297
0.72
2.35
4.2
4.1
17.36
11.71
mg/mmol
0.62
66
863
6
164
0.36
2.17
1.2
1.3
—
—
—
0
0
150
1820
0.77
2.06
5.6
5.3
0.20
0.21
e9/l
0.29
128
1533
24
133
1.83
2.01
4.2
3.4
8.42
7.65
mmol/l
0.38
24
128
47
682
0.67
1.97
5.0
4.6
—
—
—
0
0
56
783
0.69
1.94
3.4
2.7
2.22
2.17
g/l
0.33
51
720
136
1654
0.78
1.89
5.9
5.3
0.55
0.58
%
0.35
127
1533
61
835
0.70
1.88
3.2
2.7
10.15
11.26
umol/l
0.97
54
772
12
250
0.47
1.88
1.3
2.2
7.71
10.86
nmol/l
—
7
207
96
1221
0.75
1.86
5.2
5.0
—
—
—
0
0
57
788
0.70
1.86
2.1
1.6
1.83
1.72
mg/l
0.06
50
631
91
698
1.35
1.84
2.0
1.9
29.37
30.15
s
0.77
86
683
300
3336
0.82
1.83
40.9
33.0
7.65
7.32
e9/l
1.50
283
3215
300
3333
0.82
1.80
40.9
32.9
4.21
4.25
e12/l
0.70
282
3215
300
3333
0.82
1.80
40.8
32.8
30.31
30.47
pg
0.68
286
3251
300
3333
0.82
1.80
41.0
32.9
240.34
230.17
e9/l
1.61
286
3221
300
3333
0.82
1.80
41.7
33.5
37.47
38.35
%
1.15
286
3248
300
3333
0.82
1.80
40.8
32.9
92.01
92.27
fl
0.37
286
3252
27
433
0.61
1.79
1.3
1.3
—
—
—
0
0
25
146
1.74
1.79
4.2
3.3
1.69
1.74
mmol/l
0.12
25
140
298
3311
0.82
1.79
36.2
28.1
4.00
4.05
mmol/l
2.31
281
3214
298
3309
0.82
1.77
36.0
27.9
139.75
139.24
mmol/l
2.28
283
3214
300
3329
0.82
1.77
36.3
30.1
93.56
94.71
umol/l
0.15
285
3245
137
1652
0.79
1.77
5.7
5.4
9.13
9.37
%
0.43
127
1531
137
1652
0.79
1.77
5.7
5.3
2.75
2.79
%
0.08
127
1531
6
18
3.35
1.74
1.0
1.1
—
—
—
0
0
301
3333
0.83
1.72
41.2
33.2
126.99
128.22
g/l
0.67
289
3256
148
1761
0.80
1.70
5.3
5.1
0.64
0.66
e9/l
0.36
127
1454
8
31
2.59
1.66
4.0
3.2
—
—
—
0
0
16
288
0.54
1.64
3.4
4.1
0.50
0.72
%
—
6
98
53
723
0.71
1.62
3.4
2.8
21.39
21.04
%
0.07
48
677
150
1772
0.80
1.61
5.4
5.1
0.04
0.04
e9/l
0.18
128
1468
6
20
3.01
1.58
1.5
1.1
—
—
—
0
0
6
20
3.01
1.58
1.0
1.3
—
—
—
0
0
141
1673
0.80
1.57
5.7
5.5
21.43
23.57
%
1.55
132
1566
137
1627
0.80
1.53
5.9
5.4
63.15
60.48
%
1.80
131
1539
0
43
0.00
1.52
0.0
1.6
—
—
—
0
0
0
43
0.00
1.52
0.0
1.1
—
—
—
0
0
19
318
0.59
1.52
1.3
1.4
—
—
—
0
0
0
45
0.00
1.50
0.0
1.2
—
—
—
0
0
10
45
2.24
1.46
2.4
2.2
5.60
1.68
u/field
—
5
19
18
302
0.58
1.46
3.2
4.3
0.00
0.16
%
—
6
93
38
261
1.48
1.46
4.8
3.2
24.53
24.89
mmol/l
0.23
38
249
81
1017
0.77
1.44
2.5
3.0
389.05
387.13
umol/l
0.04
66
842
149
1738
0.82
1.40
3.3
3.7
2202.95
2723.51
ng/l
0.74
130
1547
31
451
0.67
1.37
1.6
2.8
7.10
11.14
umol/l
1.37
21
391
37
516
0.70
1.31
1.2
1.3
2.14
2.79
g/l
2.17
22
299
175
1996
0.83
1.30
7.3
8.4
5.26
4.59
e9/l
1.78
150
1702
108
892
1.25
1.28
1.7
1.8
454.76
7972468.07
pmol/l
0.50
85
715
5
18
2.79
1.28
1.0
1.2
—
—
—
0
0
106
1269
0.80
1.28
4.6
3.9
0.76
0.52
e6/l
0.48
94
1008
21
323
0.64
1.22
7.1
4.4
—
—
—
0
0
61
472
1.32
1.21
1.6
1.8
—
—
—
0
0
25
166
1.52
1.16
7.7
5.1
—
—
—
0
0
8
151
0.52
1.15
1.1
1.3
—
—
—
0
0
18
282
0.63
1.15
2.1
1.4
—
—
—
0
0
21
135
1.57
1.12
4.6
4.0
1.45
1.39
index
0.03
12
75
255
2787
0.86
1.09
5.2
5.0
2.01
2.13
mu/l
0.78
235
2458
38
279
1.38
1.07
3.8
3.4
6.20
6.16
ph
0.10
25
219
22
324
0.67
1.07
1.4
1.2
—
—
—
0
0
159
1796
0.85
1.04
5.5
5.3
1.57
1.75
e9/l
1.39
137
1534
5
22
2.28
1.03
1.2
1.1
—
—
—
0
0
52
655
0.78
0.99
2.3
2.3
1.80
1.78
%
0.06
42
581
16
247
0.64
0.98
1.6
1.4
—
—
—
0
0
0
29
0.00
0.98
0.0
1.2
—
311640.84
—
0
19
249
2707
0.87
0.96
7.3
7.8
83.27
87.22
u/l
0.62
227
2528
0
32
0.00
0.95
0.0
3.0
—
9.45
—
0
32
42
538
0.77
0.91
1.1
1.2
0.30
1.42
u/ml
—
5
130
243
2226
1.14
0.88
29.0
23.7
1.54
1.48
inr
0.56
222
1905
10
167
0.59
0.86
1.7
1.3
—
—
—
0
0
299
3192
0.89
0.85
30.3
22.4
31.50
31.35
mg/l
0.03
276
2812
8
141
0.56
0.83
1.6
1.2
186.50
245.08
u/ml
—
8
126
52
636
0.80
0.80
1.7
1.9
—
—
—
0
0
0
24
0.00
0.79
0.0
1.5
—
—
—
0
0
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
7
123
0.56
0.78
15.1
4.6
—
—
—
0
0
66
785
0.82
0.78
1.3
1.3
—
—
—
0
0
0
28
0.00
0.76
0.0
1.3
—
—
—
0
0
206
2234
0.89
0.74
3.9
3.9
14.90
15.22
pmol/l
0.85
183
1961
186
2029
0.88
0.74
4.9
6.0
11.73
13.78
umol/l
1.92
170
1918
71
604
1.19
0.69
5.4
6.2
1.43
1.00
mmol/l
0.28
50
466
70
597
1.19
0.67
5.5
6.3
7.42
7.41
ph
0.60
44
356
140
1543
0.88
0.65
3.0
3.2
130.19
164.46
ug/l
1.39
123
1385
113
1263
0.87
0.65
4.1
4.1
7.39
7.40
ph
0.16
83
935
19
257
0.73
0.64
1.6
1.8
125.21
164.29
ug/g
0.34
14
199
133
1467
0.88
0.63
4.2
4.0
72.45
115.81
e6/l
0.39
117
1189
78
676
1.17
0.63
2.8
2.8
0.80
0.82
mmol/l
0.91
67
633
41
498
0.81
0.62
2.3
2.4
68.36
65.90
e9/l
0.19
35
381
70
602
1.18
0.62
5.5
6.2
5.04
5.09
kpa
0.15
63
566
5
30
1.67
0.61
2.2
1.0
—
—
—
0
0
144
1577
0.89
0.61
4.7
4.6
548.78
180.05
e6/l
0.82
117
1220
70
603
1.18
0.61
5.5
6.2
10.77
11.34
kpa
0.68
63
569
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
32
254
1.27
0.60
6.8
4.4
1.02
1.02
ratio
0.86
25
231
0
21
0.00
0.60
0.0
2.0
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
30
375
0.79
0.59
3.8
3.1
4.76
5.17
e9/l
0.20
25
314
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
87
979
0.87
0.56
6.4
4.5
0.09
0.02
estimate
0.36
23
338
29
361
0.79
0.56
1.4
1.4
—
—
—
0
0
12
170
0.70
0.54
1.3
1.3
—
—
—
0
0
16
117
1.37
0.52
2.1
1.7
20.06
21.28
s
0.74
16
112
172
1847
0.91
0.51
7.2
6.3
1.20
1.20
mmol/l
0.48
153
1677
90
804
1.14
0.50
6.6
5.3
1.16
1.02
kg/l
0.50
65
560
7
46
1.52
0.48
1.6
2.0
—
—
—
0
0
127
1164
1.11
0.47
2.6
2.5
48.92
59.96
u/l
1.73
118
1065
62
543
1.15
0.46
3.2
3.5
7.38
7.37
ph
0.24
51
361
26
318
0.81
0.45
7.1
7.8
23.89
24.44
mmol/l
0.32
20
302
95
859
1.12
0.45
2.8
3.4
2.46
2.47
mmol/l
0.64
78
750
14
104
1.35
0.43
2.6
4.0
20.11
32.64
mg/l
—
9
81
11
78
1.41
0.43
1.4
1.3
—
—
—
0
0
134
1241
1.10
0.41
2.3
2.4
2.80
3.19
mg/l
1.46
111
1062
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
5.35
—
0
11
0
16
0.00
0.41
0.0
1.9
—
0.63
—
0
16
149
1388
1.09
0.40
2.1
2.3
72.84
79.94
nmol/l
2.52
122
1209
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
39
334
1.18
0.40
4.5
3.5
—
—
—
0
0
25
302
0.82
0.40
2.0
1.5
—
—
—
0
0
59
524
1.14
0.38
3.9
3.5
1.88
1.88
mmol/l
0.00
52
417
115
1238
0.91
0.37
2.2
1.8
17.47
19.97
nmol/l
0.96
104
1041
156
1652
0.93
0.35
2.6
3.2
—
—
estimate
—
0
0
19
232
0.81
0.34
2.3
2.7
—
—
—
0
0
12
154
0.77
0.32
3.5
2.0
—
0.00
estimate
—
0
39
65
714
0.90
0.32
3.7
3.6
1.73
1.87
e6/l
0.09
40
405
102
1095
0.92
0.32
3.3
3.1
4.52
4.64
e6/l
0.04
91
1006
102
1094
0.92
0.31
6.8
4.8
0.00
0.01
estimate
0.50
17
387
7
52
1.35
0.31
1.1
1.2
—
—
—
0
0
138
1300
1.08
0.30
2.7
3.4
2.33
2.34
mmol/l
0.31
118
1166
232
2409
0.94
0.29
36.9
29.7
328.37
329.70
g/l
1.02
224
2373
19
227
0.83
0.29
1.5
1.4
—
—
—
0
0
189
1803
1.06
0.29
5.2
4.9
34.06
33.46
g/l
0.76
172
1667
183
1750
1.06
0.26
5.9
4.9
44.68
104.05
ng/l
0.97
152
1441
176
1833
0.94
0.25
6.3
4.7
0.00
0.00
estimate
0.50
36
453
178
1853
0.95
0.25
6.3
4.8
0.00
3.46
estimate
0.50
36
470
6
84
0.71
0.24
1.5
1.3
—
—
—
0
0
7
91
0.77
0.22
1.4
1.5
—
—
—
0
0
41
450
0.90
0.22
2.4
2.4
64.33
65.44
g/l
0.42
33
408
0
10
0.00
0.21
0.0
1.2
—
38.50
—
0
5
0
10
0.00
0.21
0.0
1.2
—
6.45
—
0
10
0
10
0.00
0.21
0.0
1.0
—
43.70
—
0
10
0
10
0.00
0.21
0.0
1.1
—
142.35
—
0
10
0
11
0.00
0.21
0.0
1.5
—
0.09
—
0
5
8
102
0.78
0.21
4.0
13.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
34.25
—
0
8
0
13
0.00
0.21
0.0
1.1
—
17.50
—
0
8
0
13
0.00
0.21
0.0
1.0
—
0.28
—
0
5
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
6
50
1.20
0.19
1.5
1.2
—
—
—
0
0
12
99
1.21
0.19
2.2
2.2
326.63
78.49
ug/min
—
7
60
12
99
1.21
0.19
1.3
1.2
—
—
—
0
0
31
342
0.90
0.19
6.1
4.0
1.20
1.21
mmol/l
0.70
25
295
180
1857
0.96
0.18
6.2
4.8
0.00
0.01
estimate
0.50
31
441
97
1011
0.95
0.15
4.5
3.5
550.42
535.17
mosm/kgh2o
0.30
84
890
21
234
0.89
0.15
5.0
4.3
—
—
—
0
0
184
1787
1.04
0.15
2.8
2.3
87.49
91.75
pmol/l
0.71
123
976
43
460
0.93
0.15
8.1
5.9
11.30
13.59
mmol/l
1.24
37
433
96
921
1.05
0.14
6.5
4.5
145.67
307.26
ng/l
1.43
86
833
26
237
1.10
0.13
2.0
1.7
0.50
2.48
ug/l
0.94
19
203
23
251
0.91
0.12
2.4
3.1
—
—
—
0
0
14
123
1.14
0.12
1.1
1.2
—
—
—
0
0
258
2533
1.03
0.11
7.1
5.8
20006.80
2661.83
e6/l
—
5
54
201
2047
0.97
0.11
8.1
6.9
1.21
1.20
mmol/l
0.24
170
1711
67
643
1.04
0.10
6.4
6.6
105.45
104.11
mmol/l
1.48
67
643
5
44
1.14
0.10
1.6
1.2
—
—
—
0
0
17
154
1.10
0.10
1.0
1.1
—
—
—
0
0
180
1762
1.03
0.10
4.1
3.0
49.64
62.51
u/l
2.01
164
1593
245
2478
0.98
0.07
6.7
5.1
—
2.34
—
0
6
6
73
0.82
0.07
3.2
3.4
—
—
—
0
0
7
84
0.83
0.07
1.3
1.2
14.08
48.28
u/l
—
7
75
86
881
0.97
0.07
4.6
3.9
0.38
0.10
—
8
49
8
92
0.87
0.06
1.1
1.2
—
—
—
0
0
8
94
0.85
0.06
1.9
1.6
—
—
—
0
0
20
187
1.07
0.06
1.8
2.0
—
—
—
0
0
125
1269
0.98
0.05
2.5
2.8
—
—
—
0
0
15
139
1.08
0.05
4.7
2.7
423.25
282.57
mg/l
—
8
53
10
110
0.91
0.05
3.1
2.1
1.88
2.25
mg/l
—
10
84
14
130
1.08
0.04
4.8
3.2
4.17
4.13
pmol/l
0.08
14
114
37
357
1.04
0.04
5.6
4.2
7.36
7.35
ph
0.12
31
252
45
437
1.03
0.04
6.0
7.6
—
—
—
0
0
61
596
1.02
0.04
6.0
5.1
1.04
1.07
mmol/l
0.41
53
558
137
1383
0.99
0.03
7.0
5.1
0.13
0.05
estimate
0.32
31
383
149
1478
1.01
0.01
5.5
4.3
6.37
6.33
ph
0.17
81
806
12
114
1.05
0.00
1.3
1.5
—
—
—
0
0
231
2300
1.00
0.00
6.5
5.0
7.58
7.00
mmol/l
2.26
220
2195
32
314
1.02
0.00
1.3
1.2
240.00
316.57
titre
0.84
11
70
32
314
1.02
0.00
3.2
4.0
115.00
108.13
ng/l
0.09
23
274
11
108
1.02
0.00
3.8
2.0
123.91
126.15
g/l
0.14
11
85
16
157
1.02
0.00
5.5
4.8
25.33
24.58
mmol/l
0.61
16
148
18
180
1.00
0.00
1.0
1.2
—
—
—
0
0
36
357
1.01
0.00
2.1
2.3
—
—
—
0
0
11
114
0.96
0.00
1.1
1.1
—
—
—
0
0
12
118
1.02
0.00
1.4
1.3
—
30.57
—
0
11
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
8.22
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
1.10
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
0.00
—
0
7
8
84
0.95
-0.00
1.5
1.2
—
0.20
—
0
6
0
8
0.00
-0.00
0.0
2.4
—
4232.49
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
96.00
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
0.02
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
0.69
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: VD_MI – Vascular dementia (multiple infarctions)

GWS hits: 3

This endpoint is excluded (different definition than used in FinnGen).