Systemic disorders of connective tissue in diseases classified elsewhere (FG)

SYSTINOTH_FG

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters None 0 out of 7 registries used, show all original rules.	0
4. Check minimum number of events None	0
5. Include endpoints DERMATOPOLY_NEOPLASM ARTHROPATHY_NEOPLASM ARTHROPATHY_HYPERSENS	98
6. Filter based on genotype QC (FinnGen only)	77

Control definitions (FinnGen only)

Control exclude: RHEUMA_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze: DF2

NAME	SYSTINOTH_FG
CONTROL_EXCLUDE	RHEUMA_ENDPOINTS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	DERMATOPOLY_NEOPLASM\|ARTHROPATHY_NEOPLASM\|ARTHROPATHY_HYPERSENS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Systemic disorders of connective tissue in diseases classified elsewhere (FG) based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1123	499	623
Only index persons	887	401	486
Unadjusted period prevalence (%)
Whole population	0.02	0.01	0.02
Only index persons	0.02	0.01	0.02
Median age at first event (years)
Whole population	14.71	17.68	12.30
Only index persons	19.58	23.11	16.67

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	77	43	34
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	56.73	52.75	61.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
79: Matched controls
790

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M36.4*D69.0

ICD-10 Finland

Arthropathy in Henoch(-Schönlein) purpura

+∞

56.1

D69.0

ICD-10 Finland

Allergic purpura

499.7

33.5

M36.1*C90.0

ICD-10 Finland

Arthropathy in multiple myeloma

+∞

19.6

C90.0

ICD-10 Finland

Multiple myeloma

71.0

15.5

N08.2*D69.0

ICD-10 Finland

Glomerular disorders in Henoch(-Schönlein) purpura

+∞

15.1

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

5.8

14.0

140

9732/3-C42.1

ICD-O-3

Plasma cell myeloma of bone marrow

60.8

13.4

M13.9

ICD-10 Finland

Arthritis, unspecified

32.9

12.6

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

22.7

10.7

H02AB06

ATC

prednisolone; systemic

4.6

10.3

206

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

63.0

9.9

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

12.4

9.6

H02AB02

ATC

dexamethasone; systemic

5.2

8.6

M36.4

ICD-10 Finland

Arthropathy in hypersensitivity reactions classified elsewhere

+∞

8.5

R50.9

ICD-10 Finland

Fever, unspecified

4.3

7.9

J01MA12

ATC

levofloxacin; systemic

4.5

7.9

B01AB05

ATC

enoxaparin; parenteral

4.0

7.6

106

N02AA05

ATC

oxycodone; systemic

4.7

7.5

N08.2

ICD-10 Finland

Glomerular disorders in blood diseases and disorders involving the immune mechanism

+∞

7.4

H02AB07

ATC

prednisone; oral

5.0

7.0

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

44.0

6.9

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.3

6.9

KA3AT

NOMESCO Finland

Biopsy of kidney with ultrasound guidance

25.0

6.8

M17.1

ICD-10 Finland

Other primary gonarthrosis

25.0

6.8

M05BA02

ATC

clodronic acid; systemic

25.0

6.8

A49.9

ICD-10 Finland

Bacterial infection, unspecified

4.7

6.7

L04AX04

ATC

lenalidomide; oral

75.7

6.5

M04AA01

ATC

allopurinol; systemic

6.3

6.5

L95.9

ICD-10 Finland

Vasculitis limited to skin, unspecified

+∞

6.3

NE1AA

NOMESCO Finland

Pelvis X-ray examination

7.5

6.2

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

9.2

6.1

N02AB03

ATC

fentanyl; nasal, sublingual, transdermal

10.4

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037522) Nuclear Ab [Titer] in Serum

9.59

21.03

1.7

1.4

533.33

466.67

titre

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

19.70

15.25

2.0

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

11.99

12.35

11.3

3.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

13.66

11.61

1.5

1.2

1.23

1.12

g/l

0.56

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

13.66

11.61

1.5

1.1

0.23

g/l

0.07

(42870588) Differential panel, method unspecified - Blood

206

3.75

7.78

13.7

5.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

5.26

7.68

2.7

1.5

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

13.88

7.36

1.4

1.1

—

(3023520) Reticulocytes [#/volume] in Blood

4.62

7.18

2.8

3.1

70.64

65.65

e9/l

0.28

(3037756) Immunofixation for Serum or Plasma

12.60

7.07

5.6

1.1

—

(3022096) Basophils/Leukocytes in Blood

284

3.63

6.92

13.6

5.9

0.58

0.62

0.24

272

(3006504) Eosinophils/Leukocytes in Blood

285

3.61

6.87

13.5

5.9

2.15

2.65

0.93

274

(3019069) Monocytes/Leukocytes in Blood

287

3.57

6.75

13.5

6.1

7.66

8.71

2.77

278

(3017817) Protein [Mass] in Urine collected for unspecified duration

20.02

6.42

1.9

9.8

1159.11

428.60

—

(3018010) Neutrophils/Leukocytes in Blood

296

3.40

6.24

12.8

5.8

61.46

56.43

2.46

289

(3002030) Lymphocytes/Leukocytes in Blood

297

3.38

6.19

13.6

6.0

25.45

29.11

2.03

289

(3021879) Hepatitis B virus core Ab [Presence] in Serum

4.28

6.02

1.3

1.5

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

4.33

5.86

8.9

9.6

5.01

5.02

kpa

0.01

(3013650) Neutrophils [#/volume] in Blood by Automated count

354

3.40

5.66

19.3

9.8

4.57

4.10

e9/l

0.82

301

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

6.30

5.54

9.1

12.2

23.98

24.42

mmol/l

0.30

(3007164) IgA [Mass/volume] in Serum or Plasma

163

3.06

5.46

4.5

1.4

2.78

2.15

g/l

1.25

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

234

2.99

5.40

9.2

3.5

—

(3022313) Gas panel - Capillary blood

5.36

5.20

10.8

10.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.27

5.06

1.7

1.5

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

8.62

5.02

1.5

1.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

3.49

4.93

1.3

1.1

1.60

1.43

u/ml

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

5.55

4.75

1.6

1.7

1.44

1.82

g/l

0.53

(3002582) Erythrocytes [#/volume] in Urine

223

2.74

4.64

8.6

3.5

29.24

48.42

e6/l

0.62

173

(3030467) Casts [#/volume] in Urine by Automated count

190

2.64

4.24

8.4

3.3

0.20

0.41

e6/l

0.69

141

(4195642) Thrombophilia screening test

10.81

4.09

1.1

1.0

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

9.45

3.85

1.3

1.1

—

(40760888) Immunoglobulin light chains.free panel - Serum

9.45

3.85

15.9

6.6

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

12.82

3.82

1.2

1.0

—

(36304419) Bacteria [Presence] in Urine

182

2.52

3.81

8.6

3.3

—

estimate

—

(3000991) Gas panel - Venous blood

3.16

3.78

8.3

11.9

—

(3018095) Leukocytes [#/volume] in Urine

259

2.45

3.71

11.0

4.0

16.23

86.95

e6/l

1.78

180

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

113

2.61

3.46

6.0

2.8

0.32

1.17

e6/l

2.12

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

106

2.65

3.46

6.8

2.8

1.50

2.52

e6/l

0.37

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

5.20

3.35

4.4

1.9

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

6.86

3.26

1.0

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

4.93

3.22

5.1

2.0

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.90

2.99

3.1

2.2

0.21

g/l

0.13

(3007853) Bacteria identified in Skin by Aerobe culture

2.66

2.94

3.1

1.9

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

315

2.21

2.94

27.6

8.7

1.21

1.22

mmol/l

0.16

272

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

5.79

2.94

6.0

2.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

5.79

2.94

4.3

1.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

5.79

2.94

1.3

1.9

—

(40768443) Skin Pathology biopsy report

3.79

2.81

1.2

—

(3019225) pH of Specimen

2.92

2.69

27.0

4.2

7.28

7.35

0.27

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

5.01

2.66

1.3

2.1

—

(3023368) Bacteria identified in Blood by Culture

166

2.18

2.64

7.1

4.3

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.77

2.62

7.3

6.6

24.23

24.42

mmol/l

0.13

(40758558) Short blood count panel - Blood

203

2.07

2.47

10.2

6.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

5.31

2.45

1.8

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

3.92

2.44

7.9

2.6

2.88

2.94

g/l

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.41

2.42

3.1

1.6

—

(4268621) Lupus anticoagulant assay

6.58

2.40

1.8

1.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

132

2.18

2.38

1.9

1.6

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.37

2.31

1.2

1.9

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.16

2.31

8.1

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

194

1.98

2.17

6.0

2.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

106

2.19

2.15

4.4

1.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

155

2.01

2.07

2.1

2.2

—

(3025941) Bacteria identified in Stool by Culture

2.79

2.03

1.4

1.3

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

4.77

1.97

1.0

1.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

4.77

1.97

1.6

1.2

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

4.77

1.97

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.77

1.97

1.2

1.0

—

(3021589) Normoblasts [#/volume] in Blood

299

1.86

1.95

16.9

12.0

0.00

0.01

e9/l

0.56

227

(3015736) pH of Urine

290

1.86

1.94

5.9

3.0

5.75

6.27

2.76

155

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.39

1.93

1.1

1.3

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

4.37

1.85

1.8

1.7

124.60

773.39

ug/l

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

4.37

1.85

1.0

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

3.10

1.77

2.1

2.0

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.35

1.71

2.7

3.4

28.67

29.65

u/l

0.07

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.75

1.71

2.3

1.5

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

2.97

1.69

1.3

3.8

33.71

34.31

u/ml

—

(3021601) Nitrite [Presence] in Urine by Test strip

358

1.77

1.66

6.2

3.4

0.00

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

358

1.77

1.66

6.4

3.5

0.00

estimate

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.39

1.66

3.0

3.8

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.74

1.64

1.2

1.8

—

(3008898) HLA-B27 [Presence]

3.74

1.64

1.2

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.74

1.64

1.2

1.8

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.16

1.61

1.2

1.3

—

(3042936) Bacteria identified in Isolate by Culture

2.05

1.60

4.9

2.1

—

(3012516) Albumin [Mass/volume] in Urine

212

1.76

1.57

5.7

3.2

175.19

86.65

mg/l

0.51

139

(3009261) Glucose [Presence] in Urine by Test strip

362

1.74

1.56

6.4

3.5

0.00

estimate

—

(1616796) Gas panel - Central venous blood

3.48

1.54

1.6

3.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.86

1.46

3.8

2.7

—

(3034770) Mitochondria Ab [Titer] in Serum

3.26

1.46

1.0

1.3

—

(3031040) Bacteria [#/volume] in Urine by Automated count

429

1.72

1.41

5.2

4.3

—

27.17

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

3.07

1.38

1.4

1.2

—

0.01

—

(3020682) Albumin/Creatinine [Ratio] in Urine

211

1.68

1.34

6.8

4.1

24.76

14.05

mg/mmol

0.36

141

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.62

1.33

2.7

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.97

1.31

1.9

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.88

1.29

1.8

1.7

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.51

1.27

1.5

1.3

—

(3018418) pH of Serum or Plasma

188

1.66

1.24

10.3

5.2

7.40

0.07

138

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.60

1.17

1.0

1.4

—

(3049717) Cytology report of Urine Cyto stain

2.60

1.17

2.0

3.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

149

1.66

1.11

6.2

2.4

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.47

1.10

1.0

1.2

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.97

1.09

4.6

2.4

0.94

1.79

e6/l

0.21

(4035726) Immunohistochemistry procedure

2.02

1.07

1.2

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.36

1.05

1.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.36

1.05

1.0

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.80

0.99

1.5

1.9

—

(40761535) Cells panel - Urine sediment

2.00

0.92

4.3

2.8

—

(40768797) Stomach Pathology biopsy report

1.75

0.91

1.4

1.1

—

(3028626) Oxygen [Partial pressure] in Capillary blood

2.08

0.89

10.8

13.2

9.68

8.55

kpa

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

594

0.67

0.82

5.4

4.6

1.36

1.46

mmol/l

0.99

557

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.75

0.80

5.6

4.4

28.73

33.87

0.80

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.76

0.76

4.7

10.6

1.28

1.47

mmol/l

—

(3000494) Fungus identified in Specimen by Culture

1.66

0.73

3.6

1.5

—

(3017732) Neutrophils [#/volume] in Blood

1.69

0.73

3.5

3.4

6.20

4.91

e9/l

1.03

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

504

0.71

4.7

4.0

14.36

14.99

pmol/l

0.93

458

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

188

1.40

0.61

1.5

1.3

3.89

1.14

u/ml

0.47

(3029937) Albumin [Presence] in Urine by Test strip

188

1.40

0.61

5.6

3.6

0.00

0.02

estimate

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.61

0.0

1.6

—

6.38

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.61

0.0

2.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.57

0.60

1.0

—

(3002256) Pathology report gross observation

1.48

0.46

1.4

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

132

1.37

0.45

4.9

7.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

458

0.78

0.45

3.8

3.4

—

(40768793) Breast Pathology biopsy report

0.00

0.41

0.0

1.2

—

(3026008) Bacteria identified in Urine by Culture

192

1.28

0.38

4.7

3.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.43

0.36

1.0

1.3

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.39

0.35

1.5

7.3

0.35

0.58

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.38

0.34

1.5

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.71

0.33

1.7

2.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

170

1.24

0.28

2.0

1.9

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

549

0.85

0.23

37.4

18.4

13.86

13.55

0.75

541

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

102

0.76

0.23

2.0

2.7

—

(3019150) Specific gravity of Urine by Refractometry

165

0.82

0.22

6.4

3.0

1.02

kg/l

—

100

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.20

0.22

1.0

1.4

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.21

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.5

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.5

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.1

—

21.90

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

557

0.85

0.21

5.2

4.1

1.63

1.27

mmol/l

1.69

523

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

19.82

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

1.97

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.2

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

7.33

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

0.12

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.27

0.21

1.0

1.4

96.40

276.50

u/ml

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.20

0.0

1.5

—

51.89

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.20

0.0

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.17

0.19

1.3

2.0

—

(3016502) Oxygen saturation in Arterial blood

1.20

0.18

5.7

7.4

96.93

94.86

—

(36660697) Celiac disease serology panel - Serum

1.22

0.17

1.3

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

191

1.14

0.13

4.4

3.2

0.00

estimate

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

591

1.14

0.13

28.0

13.9

85.15

84.30

ml/min/173m2

0.08

535

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.17

0.10

8.0

8.9

102.50

104.36

mmol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.16

0.09

1.6

1.9

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.14

0.09

6.2

6.9

109.67

119.42

g/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.82

0.08

6.8

7.7

—

(3022145) Colonoscopy Study observation

1.04

0.07

1.6

1.4

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

118

1.12

0.07

3.2

3.8

15.57

370.11

ng/l

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

638

1.11

0.07

43.6

14.5

19.99

26.63

mg/l

1.21

516

(40768804) Tissue Pathology biopsy report

241

0.94

0.05

2.5

2.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

140

0.91

0.05

3.7

4.2

18.61

24.39

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

280

1.06

0.04

6.1

2.8

—

estimate

—

(40761511) CBC panel - Blood by Automated count

658

0.93

0.03

31.9

12.4

—

(3003694) ABO and Rh group [Type] in Blood

196

0.96

0.00

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

267

1.02

0.00

5.3

3.4

0.00

estimate

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

255

0.97

0.00

2.9

1.9

84.96

99.09

pmol/l

0.62

135

(1761868) Lipid panel - Serum or Plasma

226

1.02

0.00

2.2

3.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.98

0.00

2.0

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

0.29

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

3.0

—

88.14

—

(3011897) Casein IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

2.2

—

5.56

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.7

—

2.80

—

(3000492) Spirometry study

0.90

-0.00

1.2

1.6

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

0.00

-0.00

0.0

1.0

—

169.80

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

0.84

-0.00

1.2

1.4

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

1.4

—

11.26

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.00

-0.00

1.9

2.2

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

-0.00

0.0

1.2

—

110.00

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

9.3

—

180.50

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.6

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

2.2

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

-0.00

0.0

6.8

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

5.0

—

1.29

—

(44813793) Dust mix specific IgE antibody measurement

0.00

-0.00

0.0

1.2

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

3.2

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

247.83

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.2

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

-0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

3.3

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.1

—

7.99

—

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

0.07

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint SYSTINOTH_FG and mortality.

Females

Parameter	HR [95% CI]	p-value
SYSTINOTH_FG	6.501 [4.18, 10.11]	< 0.001
Birth year	0.999 [0.99, 1.01]	0.748

During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 452 females with SYSTINOTH_FG died.

Males

Parameter	HR [95% CI]	p-value
SYSTINOTH_FG	4.561 [2.89, 7.19]	< 0.001
Birth year	0.99 [0.98, 1.0]	0.024

During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 560 males with SYSTINOTH_FG died.

Mortality risk

Mortality risk for people of age

years, who have SYSTINOTH_FG.

N-year risk	Females	Males
1	0.869%	0.862%
5	4.764%	5.226%
10	10.807%	12.795%
15	18.419%	24.153%
20	30.062%	38.855%

Relationships between endpoints

↥

Index endpoint: SYSTINOTH_FG – Systemic disorders of connective tissue in diseases classified elsewhere (FG)

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Systemic disorders of connective tissue in diseases classified elsewhere (FG)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints