Systemic disorders of connective tissue in diseases classified elsewhere (FG)

SYSTINOTH_FG

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

77

6. Filter based on genotype QC (FinnGen only)

75

Control definitions (FinnGen only)

Control exclude
RHEUMA_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze
DF2

Similar endpoints

List of similar endpoints to Systemic disorders of connective tissue in diseases classified elsewhere (FG) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1123 499 623
Only index persons 887 401 486
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 14.71 17.68 12.30
Only index persons 19.58 23.11 16.67

-FinnGen-

Key figures

All Female Male
Number of individuals 75 43 32
Unadjusted period prevalence (%) 0.02 0.02 0.01
Median age at first event (years) 56.59 52.75 61.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
77
Matched controls
770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A98, ,
ICD-O-3
+∞
83.0
64
*
N02BE01, ,
ATC
paracetamol; systemic, rectal
+∞
81.2
63
*
J01DB01, ,
ATC
cefalexin; oral
+∞
79.5
62
*
J01CA04, ,
ATC
amoxicillin; systemic
+∞
74.5
59
*
A02BC02, ,
ATC
pantoprazole; systemic
+∞
71.3
57
*
M01AE01, ,
ATC
ibuprofen; systemic, rectal
+∞
65.1
53
*
WX110, ,
ICD-O-3
+∞
60.6
50
*
J01CE02, ,
ATC
phenoxymethylpenicillin; oral
+∞
59.2
49
*
H02AB06, ,
ATC
prednisolone; systemic
+∞
59.2
49
*
SAA01, ,
ICD-O-3
+∞
57.7
48
*
J01AA02, ,
ATC
doxycycline; systemic
+∞
56.3
47
*
M364, D690,
ICD-10 Finland
Arthropathy in Henoch(-Schönlein) purpura
+∞
53.5
45
*
A12AX, ,
ATC
Calcium, combinations with vitamin D and/or other drugs
+∞
53.5
45
*
GD1AA, ,
ICD-O-3
+∞
52.1
44
*
K021, ,
ICD-O-3
+∞
48.0
41
*
SAA02, ,
ICD-O-3
+∞
46.7
40
*
J01DA01, ,
ATC
[U] cefalexin
+∞
45.4
39
*
J01CR02, ,
ATC
amoxicillin and beta-lactamase inhibitor; systemic
+∞
44.0
38
*
KMAK, ,
ICD-O-3
+∞
42.7
37
*
M01AB05, ,
ATC
diclofenac; systemic, rectal
+∞
41.4
36
*
R03AC02, ,
ATC
salbutamol; inhalant
+∞
41.4
36
*
J01FA10, ,
ATC
azithromycin; systemic
+∞
40.2
35
*
SFA10, ,
ICD-O-3
+∞
40.2
35
*
ZXD10, ,
ICD-O-3
+∞
38.9
34
*
M01AE02, ,
ATC
naproxen; oral, rectal
+∞
38.9
34
*
N02AX02, ,
ATC
tramadol; systemic, rectal
+∞
37.6
33
*
EB1SA, ,
ICD-O-3
+∞
37.6
33
*
SFA20, ,
ICD-O-3
+∞
37.6
33
*
Z012, ,
ICD-O-3
+∞
36.4
32
*
R104, ,
ICD-10 Finland
Other and unspecified abdominal pain
+∞
35.1
31
*
WX290, ,
ICD-O-3
+∞
35.1
31
*
E0000UV, ,
ATC
+∞
35.1
31
*
I10, ,
ICD-10 Finland
Essential (primary) hypertension
+∞
33.9
30
*
EB1HA, ,
ICD-O-3
+∞
33.9
30
*
D690, ,
ICD-10 Finland
Allergic purpura
+∞
33.9
30
*
M03BX02, ,
ATC
tizanidine; oral
+∞
33.9
30
*
C03CA01, ,
ATC
furosemide; systemic
+∞
32.6
29
*
B01AB05, ,
ATC
enoxaparin; parenteral
+∞
32.6
29
*
EB1AA, ,
ICD-O-3
+∞
32.6
29
*
N02AA59, ,
ATC
codeine, combinations excl. psycholeptics; systemic
+∞
32.6
29
*
R06AE07, ,
ATC
cetirizine; oral
+∞
31.4
28
*
P01AB01, ,
ATC
metronidazole; oral, rectal
+∞
31.4
28
*
WZC00, ,
ICD-O-3
+∞
31.4
28
*
R01AD09, ,
ATC
mometasone; nasal
+∞
31.4
28
*
ZXE00, ,
ICD-O-3
+∞
31.4
28
*
J069, ,
ICD-O-3
+∞
31.4
28
*
C07AB07, ,
ATC
bisoprolol; oral
+∞
31.4
28
*
SAA03, ,
ICD-O-3
+∞
31.4
28
*
C08CA01, ,
ATC
amlodipine; oral
+∞
30.2
27
*
M01AH05, ,
ATC
etoricoxib; oral
+∞
30.2
27
*
J01FA06, ,
ATC
roxithromycin; oral
+∞
30.2
27
*
N05CF01, ,
ATC
zopiclone; oral
+∞
29.0
26
*
J01FF01, ,
ATC
clindamycin; systemic
+∞
29.0
26
*
WYA05, ,
ICD-O-3
+∞
27.8
25
*
N02AJ06, ,
ATC
codeine and paracetamol; systemic
+∞
27.8
25
*
Z3231, ,
ICD-O-3
+∞
27.8
25
*
-1, ,
ICD-O-3
+∞
27.8
25
*
S18, ,
ICD-O-3
+∞
27.8
25
*
JN3AE, ,
ICD-O-3
+∞
27.8
25
*
ZXD05, ,
ICD-O-3
+∞
26.6
24
*
S01XA20, ,
ATC
artificial tears and other indifferent preparations; ophthalmic
+∞
26.6
24
*
J01MA12, ,
ATC
levofloxacin; systemic
+∞
26.6
24
*
TPH04, ,
ICD-O-3
+∞
26.6
24
*
SPAT1249, ,
ICD-O-3
+∞
25.4
23
*
UJD10, ,
ICD-O-3
+∞
25.4
23
*
J01MA02, ,
ATC
ciprofloxacin; systemic
+∞
25.4
23
*
Z2221, ,
ICD-O-3
+∞
25.4
23
*
W01, ,
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
+∞
24.2
22
*
ZXE10, ,
ICD-O-3
+∞
24.2
22
*
SPAT1263, ,
ICD-O-3
+∞
24.2
22
*
I10, ,
ICD-O-3
+∞
24.2
22
*
N06AX11, ,
ATC
mirtazapine; oral
+∞
24.2
22
*
J189, ,
ICD-10 Finland
Pneumonia, unspecified
+∞
24.2
22
*
R4110, ,
ICD-O-3
+∞
24.2
22
*
SPAT1253, ,
ICD-O-3
+∞
24.2
22
*
R01BA52, ,
ATC
pseudoephedrine, combinations; oral
+∞
24.2
22
*
J01CA08, ,
ATC
pivmecillinam; oral
+∞
24.2
22
*
ZXA00, ,
ICD-O-3
+∞
24.2
22
*
A02BC05, ,
ATC
esomeprazole; systemic
+∞
24.2
22
*
N05BA04, ,
ATC
oxazepam; oral
+∞
24.2
22
*
A03FA01, ,
ATC
metoclopramide; systemic, rectal
+∞
24.2
22
*
SDA03, ,
ICD-O-3
+∞
23.1
21
*
R06AX27, ,
ATC
desloratadine; oral
+∞
23.1
21
*
J02AC01, ,
ATC
fluconazole; systemic
+∞
23.1
21
*
SPAT1256, ,
ICD-O-3
+∞
23.1
21
*
AA1AD, ,
ICD-O-3
+∞
23.1
21
*
N02AA05, ,
ATC
oxycodone; systemic
+∞
23.1
21
*
C10AA05, ,
ATC
atorvastatin; oral
+∞
23.1
21
*
WZB00, ,
ICD-O-3
+∞
23.1
21
*
SFA30, ,
ICD-O-3
+∞
23.1
21
*
D07AC01, ,
ATC
betamethasone; topical
+∞
21.9
20
*
EBA00, ,
ICD-O-3
+∞
21.9
20
*
A09, ,
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
+∞
21.9
20
*
H02AB02, ,
ATC
dexamethasone; systemic
+∞
21.9
20
*
G03CA03, ,
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
+∞
21.9
20
*
SPAT1325, ,
ICD-O-3
+∞
21.9
20
*
A499, ,
ICD-10 Finland
Bacterial infection, unspecified
+∞
20.8
19
*
R01AD08, ,
ATC
fluticasone; nasal
+∞
20.8
19
*
R05FA02, ,
ATC
opium derivatives and expectorants; systemic
+∞
20.8
19
*
R01AD12, ,
ATC
fluticasone furoate; nasal
+∞
20.8
19
*
R05FB02, ,
ATC
cough suppressants and expectorants; systemic
+∞
20.8
19
*
R509, ,
ICD-10 Finland
Fever, unspecified
+∞
20.8
19
*
SPAT1153, ,
ICD-O-3
+∞
20.8
19
*
M796, ,
ICD-O-3
+∞
20.8
19
*
SCA01, ,
ICD-O-3
+∞
19.6
18
*
H02AB07, ,
ATC
prednisone; oral
+∞
19.6
18
*
H03AA01, ,
ATC
levothyroxine sodium; systemic
+∞
19.6
18
*
Z871, ,
ICD-O-3
+∞
19.6
18
*
XF400, ,
ICD-O-3
+∞
19.6
18
*
X59, ,
ICD-10 Finland
Exposure to unspecified factor
+∞
19.6
18
*
M361, C900,
ICD-10 Finland
Arthropathy in multiple myeloma
+∞
19.6
18
*
A02BC01, ,
ATC
omeprazole; systemic
+∞
19.6
18
*
C900, ,
ICD-10 Finland
Multiple myeloma
+∞
18.5
17
*
M04AA01, ,
ATC
allopurinol; systemic
+∞
18.5
17
*
WX408, ,
ICD-O-3
+∞
18.5
17
*
J01EE02, ,
ATC
sulfadiazine and trimethoprim; systemic
+∞
18.5
17
*
D07AB02, ,
ATC
hydrocortisone butyrate; topical
+∞
18.5
17
*
117, ,
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
+∞
18.5
17
*
Z3226, ,
ICD-O-3
+∞
18.5
17
*
ZXA05, ,
ICD-O-3
+∞
18.5
17
*
SPAT1312, ,
ICD-O-3
+∞
18.5
17
*
EBA10, ,
ICD-O-3
+∞
18.5
17
*
N03AX16, ,
ATC
[U] pregabalin
+∞
18.5
17
*
R01AD58, ,
ATC
fluticasone, combinations; nasal
+∞
18.5
17
*
CJE20, ,
ICD-O-3
+∞
17.3
16
*
C10AA01, ,
ATC
simvastatin; oral
+∞
17.3
16
*
NA3AA, ,
ICD-O-3
+∞
17.3
16
*
S01CA01, ,
ATC
dexamethasone and antiinfectives; ophthalmic
+∞
17.3
16
*
A02BC03, ,
ATC
lansoprazole; oral
+∞
17.3
16
*
M01AE03, ,
ATC
ketoprofen; systemic, rectal
+∞
17.3
16
*
N06AB10, ,
ATC
escitalopram; oral
+∞
17.3
16
*
R074, ,
ICD-10 Finland
Chest pain, unspecified
+∞
17.3
16
*
C09CA01, ,
ATC
losartan; oral
+∞
17.3
16
*
K0364, ,
ICD-O-3
+∞
17.3
16
*
EBA05, ,
ICD-O-3
+∞
17.3
16
*
SPAT1310, ,
ICD-O-3
+∞
17.3
16
*
N06AB04, ,
ATC
citalopram; systemic
+∞
17.3
16
*
A06AC01, ,
ATC
ispaghula (psylla seeds); oral
+∞
17.3
16
*
FM1EE, ,
ICD-O-3
+∞
17.3
16
*
C09AA05, ,
ATC
ramipril; oral
+∞
16.2
15
*
205, ,
Kela drug reimbursment
Chronic hypertension
+∞
16.2
15
*
WX404, ,
ICD-O-3
+∞
16.2
15
*
N05AH04, ,
ATC
quetiapine; oral
+∞
16.2
15
*
M139, ,
ICD-10 Finland
Arthritis, unspecified
+∞
16.2
15
*
G473, ,
ICD-10 Finland
Sleep apnoea
+∞
16.2
15
*
J05AB11, ,
ATC
valaciclovir; oral
+∞
16.2
15
*
R53, ,
ICD-10 Finland
Malaise and fatigue
+∞
16.2
15
*
GD1QA, ,
ICD-O-3
+∞
16.2
15
*
J01EA01, ,
ATC
trimethoprim; systemic
+∞
16.2
15
*
E000001, ,
ATC
+∞
16.2
15
*
C09AA02, ,
ATC
enalapril; systemic
+∞
16.2
15
*
J01DA09, ,
ATC
[U] cefadroxil
+∞
16.2
15
*
D82, ,
ICD-O-3
+∞
16.2
15
*
202, ,
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
+∞
16.2
15
*
C09CA06, ,
ATC
candesartan; oral
+∞
16.2
15
*
NG1AA, ,
ICD-O-3
+∞
15.1
14
*
M01AC06, ,
ATC
meloxicam; systemic, rectal
+∞
15.1
14
*
J069, ,
ICD-10 Finland
Acute upper respiratory infection, unspecified
+∞
15.1
14
*
N082, D690,
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
15.1
14
*
WX002, ,
ICD-O-3
+∞
15.1
14
*
SPAT1223, ,
ICD-O-3
+∞
15.1
14
*
D07AC13, ,
ATC
mometasone; topical
+∞
15.1
14
*
R060, ,
ICD-10 Finland
Dyspnoea
+∞
15.1
14
*
M545, ,
ICD-O-3
+∞
15.1
14
*
NE1AA, ,
ICD-O-3
+∞
15.1
14
*
K045, ,
ICD-O-3
+∞
15.1
14
*
L17, ,
ICD-O-3
+∞
15.1
14
*
WZA90, ,
ICD-O-3
+∞
15.1
14
*
D07AD01, ,
ATC
clobetasol; topical
+∞
15.1
14
*
R83, ,
ICD-O-3
+∞
15.1
14
*
UJF32, ,
ICD-O-3
+∞
15.1
14
*
M796, ,
ICD-10 Finland
Pain in limb
+∞
15.1
14
*
R05, ,
ICD-O-3
+∞
15.1
14
*
M01AX17, ,
ATC
nimesulide; oral
+∞
15.1
14
*
M02AA07, ,
ATC
piroxicam; topical
+∞
14.0
13
*
D07AA02, ,
ATC
hydrocortisone; topical
+∞
14.0
13
*
VALMI, ,
ICD-O-3
+∞
14.0
13
*
R03BA05, ,
ATC
fluticasone; inhalant
+∞
14.0
13
*
FM1AE, ,
ICD-O-3
+∞
14.0
13
*
R05DA20, ,
ATC
opium alkaloids and derivatives - combinations
+∞
14.0
13
*
SPAT1306, ,
ICD-O-3
+∞
14.0
13
*
TQX10, ,
ICD-O-3
+∞
14.0
13
*
D01AC20, ,
ATC
imidazoles/triazoles in combination with corticosteroids; topical
+∞
14.0
13
*
103, ,
Kela drug reimbursment
Diabetes, insulin-treated
+∞
14.0
13
*
ZX120, ,
ICD-O-3
+∞
14.0
13
*
S01GX01, ,
ATC
cromoglicic acid; ophthalmic
+∞
14.0
13
*
WX320, ,
ICD-O-3
+∞
14.0
13
*
GD1UA, ,
ICD-O-3
+∞
14.0
13
*
J05AB01, ,
ATC
aciclovir; systemic
+∞
14.0
13
*
C07AA05, ,
ATC
propranolol; systemic
+∞
14.0
13
*
R74, ,
ICD-O-3
+∞
14.0
13
*
C421, 9732, 3
O3
61.1
13.4
15
*
C03EA01, ,
ATC
hydrochlorothiazide and potassium-sparing agents; oral
+∞
12.9
12
*
NA3BG, ,
ICD-O-3
+∞
12.9
12
*
NH1AA, ,
ICD-O-3
+∞
12.9
12
*
A06AD11, ,
ATC
lactulose; oral
+∞
12.9
12
*
Z018, ,
ICD-10 Finland
Other specified special examinations
+∞
12.9
12
*
KH1AE, ,
ICD-O-3
+∞
12.9
12
*
A03, ,
ICD-O-3
+∞
12.9
12
*
L309, ,
ICD-10 Finland
Dermatitis, unspecified
+∞
12.9
12
*
R103, ,
ICD-10 Finland
Pain localized to other parts of lower abdomen
+∞
12.9
12
*
SPAT1250, ,
ICD-O-3
+∞
12.9
12
*
L15, ,
ICD-O-3
+∞
12.9
12
*
R21, ,
ICD-O-3
+∞
12.9
12
*
NK4XE, ,
ICD-O-3
+∞
12.9
12
*
N390, ,
ICD-10 Finland
Urinary tract infection, site not specified
+∞
12.9
12
*
R06AX22, ,
ATC
ebastine; oral
+∞
12.9
12
*
PH2AE, ,
ICD-O-3
+∞
12.9
12
*
SPAT1222, ,
ICD-O-3
+∞
12.9
12
*
SPAT1301, ,
ICD-O-3
+∞
12.9
12
*
N05CF02, ,
ATC
zolpidem; oral
+∞
12.9
12
*
I48, ,
ICD-10 Finland
Atrial fibrillation and flutter
+∞
12.9
12
*
SDA01, ,
ICD-O-3
+∞
12.9
12
*
WX700, ,
ICD-O-3
+∞
12.9
12
*
Z760, ,
ICD-O-3
+∞
12.9
12
*
J01EE01, ,
ATC
sulfamethoxazole and trimethoprim; systemic
+∞
12.9
12
*
D19, ,
ICD-O-3
+∞
12.9
12
*
NH3AA, ,
ICD-O-3
+∞
11.8
11
*
G04CA02, ,
ATC
tamsulosin; oral
+∞
11.8
11
*
A46, ,
ICD-10 Finland
Erysipelas
+∞
11.8
11
*
SFC01, ,
ICD-O-3
+∞
11.8
11
*
R06AX13, ,
ATC
loratadine; oral
+∞
11.8
11
*
N06AX16, ,
ATC
venlafaxine; oral
+∞
11.8
11
*
M03BC01, ,
ATC
orphenadrine (citrate); systemic
+∞
11.8
11
*
SDA02, ,
ICD-O-3
+∞
11.8
11
*
A02BA02, ,
ATC
ranitidine; systemic
+∞
11.8
11
*
J01MA14, ,
ATC
moxifloxacin; systemic
+∞
11.8
11
*
U072, ,
ICD-O-3
+∞
11.8
11
*
M03BC51, ,
ATC
orphenadrine, combinations; systemic
+∞
11.8
11
*
R53, ,
ICD-O-3
+∞
11.8
11
*
Z010, ,
ICD-10 Finland
Examination of eyes and vision
+∞
11.8
11
*
N10, ,
ICD-10 Finland
Acute tubulo-interstitial nephritis
+∞
11.8
11
*
C10AA07, ,
ATC
rosuvastatin; oral
+∞
11.8
11
*
P01, ,
ICD-O-3
+∞
11.8
11
*
J01FA01, ,
ATC
erythromycin; systemic
+∞
11.8
11
*
K0365, ,
ICD-O-3
+∞
11.8
11
*
Z000, ,
ICD-O-3
+∞
11.8
11
*
R42, ,
ICD-10 Finland
Dizziness and giddiness
+∞
11.8
11
*
R03AK07, ,
ATC
formoterol and budesonide; inhalant
+∞
11.8
11
*
A04AA01, ,
ATC
ondansetron; systemic, rectal
+∞
11.8
11
*
M255, ,
ICD-O-3
+∞
11.8
11
*
J01DA06, ,
ATC
[U] cefuroxime
+∞
11.8
11
*
A10BA02, ,
ATC
metformin; oral
+∞
11.8
11
*
SPAT1216, ,
ICD-O-3
+∞
11.8
11
*
H251, ,
ICD-10 Finland
Senile nuclear cataract
+∞
10.7
10
*
A09, ,
ICD-O-3
+∞
10.7
10
*
R01AD01, ,
ATC
beclometasone; nasal
+∞
10.7
10
*
SPAT1149, ,
ICD-O-3
+∞
10.7
10
*
SPAT1317, ,
ICD-O-3
+∞
10.7
10
*
F419, ,
ICD-O-3
+∞
10.7
10
*
OAB43, ,
ICD-O-3
+∞
10.7
10
*
J01FA09, ,
ATC
clarithromycin; systemic
+∞
10.7
10
*
SCA02, ,
ICD-O-3
+∞
10.7
10
*
M255, ,
ICD-10 Finland
Pain in joint
+∞
10.7
10
*
WX402, ,
ICD-O-3
+∞
10.7
10
*
FN1AC, ,
ICD-O-3
+∞
10.7
10
*
B01AC04, ,
ATC
clopidogrel; oral
+∞
10.7
10
*
DM1AA, ,
ICD-O-3
+∞
10.7
10
*
B02AA02, ,
ATC
tranexamic acid; systemic
+∞
10.7
10
*
M545, ,
ICD-10 Finland
Low back pain
+∞
10.7
10
*
SDE02, ,
ICD-O-3
+∞
10.7
10
*
N02AB03, ,
ATC
fentanyl; nasal, sublingual, transdermal
+∞
10.7
10
*
J459, ,
ICD-10 Finland
Asthma, unspecified
+∞
10.7
10
*
L03, ,
ICD-O-3
+∞
10.7
10
*
J010, ,
ICD-O-3
+∞
10.7
10
*
ZXA10, ,
ICD-O-3
+∞
10.7
10
*
L28, ,
ICD-O-3
+∞
10.7
10
*
D690, ,
ICD-O-3
+∞
10.7
10
*
JN1AE, ,
ICD-O-3
+∞
10.7
10
*
E119, ,
ICD-10 Finland
Type 2 diabetes mellitus, without complications
+∞
10.7
10
*
R5180, ,
ICD-10 Finland
Headache
+∞
10.7
10
*
M05BA02, ,
ATC
clodronic acid; systemic
+∞
9.6
9
*
N179, ,
ICD-10 Finland
Acute renal failure, unspecified
+∞
9.6
9
*
206, ,
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
+∞
9.6
9
*
A29, ,
ICD-O-3
+∞
9.6
9
*
I251, ,
ICD-10 Finland
Atherosclerotic heart disease
+∞
9.6
9
*
T814, ,
ICD-10 Finland
Infection following a procedure, not elsewhere classified
+∞
9.6
9
*
N06AX21, ,
ATC
duloxetine; oral
+∞
9.6
9
*
R06AE09, ,
ATC
levocetirizine; oral
+∞
9.6
9
*
XPX99, ,
ICD-O-3
+∞
9.6
9
*
R5110, ,
ICD-O-3
+∞
9.6
9
*
XX3DW, ,
ICD-O-3
+∞
9.6
9
*
TNX10, ,
ICD-O-3
+∞
9.6
9
*
207, ,
Kela drug reimbursment
Chronic arrhythmias
+∞
9.6
9
*
JN3AD, ,
ICD-O-3
+∞
9.6
9
*
L29, ,
ICD-O-3
+∞
9.6
9
*
D01BA02, ,
ATC
terbinafine; oral
+∞
9.6
9
*
NF1AA, ,
ICD-O-3
+∞
9.6
9
*
B01AA03, ,
ATC
warfarin; systemic
+∞
9.6
9
*
R11, ,
ICD-10 Finland
Nausea and vomiting
+∞
9.6
9
*
C07AB02, ,
ATC
metoprolol; systemic
+∞
9.6
9
*
E039, ,
ICD-10 Finland
Hypothyroidism, unspecified
+∞
9.6
9
*
SPAT1156, ,
ICD-O-3
+∞
9.6
9
*
M01AH02, ,
ATC
rofecoxib; oral
+∞
9.6
9
*
QDB10, ,
ICD-O-3
+∞
9.6
9
*
M01AX05, ,
ATC
glucosamine; oral
+∞
9.6
9
*
R060, ,
ICD-O-3
+∞
9.6
9
*
E780, ,
ICD-O-3
+∞
9.6
9
*
H02AB04, ,
ATC
methylprednisolone; systemic
+∞
9.6
9
*
SDA04, ,
ICD-O-3
+∞
9.6
9
*
I639, ,
ICD-10 Finland
Cerebral infarction, unspecified
+∞
9.6
9
*
Z024, ,
ICD-O-3
+∞
9.6
9
*
I509, ,
ICD-10 Finland
Heart failure, unspecified
+∞
9.6
9
*
KA3AT, ,
ICD-O-3
+∞
9.6
9
*
LC2BE, ,
ICD-O-3
+∞
9.6
9
*
F329, ,
ICD-10 Finland
Depressive episode, unspecified
+∞
9.6
9
*
NK6QA, ,
ICD-O-3
+∞
9.6
9
*
XW000, ,
ICD-O-3
+∞
9.6
9
*
SPAT1212, ,
ICD-O-3
+∞
9.6
9
*
C01DA08, ,
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
+∞
9.6
9
*
M05BA04, ,
ATC
alendronic acid; oral
+∞
9.6
9
*
GD1PA, ,
ICD-O-3
+∞
8.5
8
*
D02AE01, ,
ATC
carbamide; topical
+∞
8.5
8
*
351, ,
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
8.5
8
*
ND2AA, ,
ICD-O-3
+∞
8.5
8
*
R31, ,
ICD-10 Finland
Unspecified haematuria
+∞
8.5
8
*
L04AX03, ,
ATC
methotrexate; systemic
+∞
8.5
8
*
WYA30, ,
ICD-O-3
+∞
8.5
8
*
SPAT1254, ,
ICD-O-3
+∞
8.5
8
*
OAA65, ,
ICD-O-3
+∞
8.5
8
*
C01DA02, ,
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
+∞
8.5
8
*
ZXE20, ,
ICD-O-3
+∞
8.5
8
*
290, ,
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
8.5
8
*
SDE03, ,
ICD-O-3
+∞
8.5
8
*
J01AA04, ,
ATC
lymecycline; systemic
+∞
8.5
8
*
K021, ,
ICD-10 Finland
Caries of dentine
+∞
8.5
8
*
UJF30, ,
ICD-O-3
+∞
8.5
8
*
SFA00, ,
ICD-O-3
+∞
8.5
8
*
Z712, ,
ICD-O-3
+∞
8.5
8
*
SPAT1283, ,
ICD-O-3
+∞
8.5
8
*
JN3BD, ,
ICD-O-3
+∞
8.5
8
*
JN4AD, ,
ICD-O-3
+∞
8.5
8
*
TKC20, ,
ICD-O-3
+∞
8.5
8
*
Z011, ,
ICD-10 Finland
Examination of ears and hearing
+∞
8.5
8
*
Z039, ,
ICD-10 Finland
Observation for suspected disease or condition, unspecified
+∞
8.5
8
*
215, ,
Kela drug reimbursment
Diabetes, non-insulin-treated
+∞
8.5
8
*
M791, ,
ICD-O-3
+∞
8.5
8
*
NB1AA, ,
ICD-O-3
+∞
8.5
8
*
D07AB08, ,
ATC
desonide; topical
+∞
8.5
8
*
X58, ,
ICD-10 Finland
Exposure to other specified factors
+∞
8.5
8
*
D06BX01, ,
ATC
metronidazole; topical
+∞
8.5
8
*
TPH20, ,
ICD-O-3
+∞
8.5
8
*
M01AH01, ,
ATC
celecoxib; oral
+∞
8.5
8
*
J45, ,
ICD-O-3
+∞
8.5
8
*
K0382, ,
ICD-O-3
+∞
8.5
8
*
SPAT1316, ,
ICD-O-3
+∞
8.5
8
*
N300, ,
ICD-10 Finland
Acute cystitis
+∞
8.5
8
*
G04CB01, ,
ATC
finasteride; oral
+∞
8.5
8
*
130, ,
Kela drug reimbursment
Malignant tumour
+∞
8.5
8
*
B01AF01, ,
ATC
rivaroxaban; oral
+∞
8.5
8
*
R03DC03, ,
ATC
montelukast; oral
+∞
8.5
8
*
J209, ,
ICD-O-3
+∞
8.5
8
*
C01DA14, ,
ATC
isosorbide mononitrate; oral
+∞
8.5
8
*
Z2446, ,
ICD-O-3
+∞
8.5
8
*
N05CD07, ,
ATC
temazepam; oral
+∞
8.5
8
*
C900, ,
ICD-O-3
+∞
8.5
8
*
R03BA02, ,
ATC
budesonide; inhalant
+∞
8.5
8
*
Z004, ,
ICD-10 Finland
General psychiatric examination, not elsewhere classified
+∞
8.5
8
*
N390, ,
ICD-O-3
+∞
8.5
8
*
G03FB05, ,
ATC
norethisterone and estrogen; systemic
+∞
8.5
8
*
R03BA01, ,
ATC
beclometasone; inhalant
+∞
8.5
8
*
E039, ,
ICD-O-3
+∞
8.5
8
*
A97, ,
ICD-O-3
+∞
8.5
8
*
SPAT1315, ,
ICD-O-3
+∞
7.4
7
*
JN4BD, ,
ICD-O-3
+∞
7.4
7
*
M232, ,
ICD-10 Finland
Derangement of meniscus due to old tear or injury
+∞
7.4
7
*
N05BA01, ,
ATC
diazepam; systemic, rectal
+∞
7.4
7
*
N02CC01, ,
ATC
sumatriptan; nasal, systemic, rectal
+∞
7.4
7
*
WYA10, ,
ICD-O-3
+∞
7.4
7
*
C09DA01, ,
ATC
losartan and diuretics; oral
+∞
7.4
7
*
W11, ,
ICD-O-3
+∞
7.4
7
*
L04AX01, ,
ATC
azathioprine; systemic
+∞
7.4
7
*
H0410, ,
ICD-O-3
+∞
7.4
7
*
NG1BG, ,
ICD-O-3
+∞
7.4
7
*
DM1QA, ,
ICD-O-3
+∞
7.4
7
*
N06AA09, ,
ATC
amitriptyline; systemic
+∞
7.4
7
*
N05BA12, ,
ATC
alprazolam; oral
+∞
7.4
7
*
J20, ,
ICD-O-3
+∞
7.4
7
*
SPAT1308, ,
ICD-O-3
+∞
7.4
7
*
L030, ,
ICD-O-3
+∞
7.4
7
*
E7801, ,
ICD-10 Finland
Pure hypercholesterolaemia
+∞
7.4
7
*
M544, ,
ICD-O-3
+∞
7.4
7
*
H903, ,
ICD-10 Finland
Sensorineural hearing loss, bilateral
+∞
7.4
7
*
K802, ,
ICD-10 Finland
Calculus of gallbladder without cholecystitis
+∞
7.4
7
*
A10AC01, ,
ATC
insulin (human); parenteral
+∞
7.4
7
*
A04, ,
ICD-O-3
+∞
7.4
7
*
WX100, ,
ICD-O-3
+∞
7.4
7
*
A07AA02, ,
ATC
nystatin; oral
+∞
7.4
7
*
SPAT1305, ,
ICD-O-3
+∞
7.4
7
*
SBB10, ,
ICD-O-3
+∞
7.4
7
*
OAA67, ,
ICD-O-3
+∞
7.4
7
*
F412, ,
ICD-O-3
+∞
7.4
7
*
SFA40, ,
ICD-O-3
+∞
7.4
7
*
H0410, ,
ICD-10 Finland
Dry eye syndrome
+∞
7.4
7
*
XF600, ,
ICD-O-3
+∞
7.4
7
*
I702, ,
ICD-10 Finland
Atherosclerosis of arteries of extremities
+∞
7.4
7
*
Z712, ,
ICD-10 Finland
Person consulting for explanation of investigation findings
+∞
7.4
7
*
SGC00, ,
ICD-O-3
+∞
7.4
7
*
G473, ,
ICD-O-3
+∞
7.4
7
*
D07XC01, ,
ATC
betamethasone; topical
+∞
7.4
7
*
G03FB06, ,
ATC
medroxyprogesterone and estrogen; systemic
+∞
7.4
7
*
N01, ,
ICD-O-3
+∞
7.4
7
*
M364, ,
ICD-10 Finland
Arthropathy in hypersensitivity reactions classified elsewhere
+∞
7.4
7
*
R01BA51, ,
ATC
phenylpropanolamine, combinations; oral
+∞
7.4
7
*
A10BB12, ,
ATC
glimepiride; oral
+∞
7.4
7
*
Z718, ,
ICD-O-3
+∞
7.4
7
*
J209, ,
ICD-10 Finland
Acute bronchitis, unspecified
+∞
7.4
7
*
SPAT1262, ,
ICD-O-3
+∞
7.4
7
*
L04AX04, ,
ATC
lenalidomide; oral
+∞
7.4
7
*
R074, ,
ICD-O-3
+∞
7.4
7
*
A46, ,
ICD-O-3
+∞
7.4
7
*
K020, ,
ICD-O-3
+∞
7.4
7
*
R03AC03, ,
ATC
terbutaline; inhalant
+∞
7.4
7
*
G03FA01, ,
ATC
norethisterone and estrogen; systemic
+∞
7.4
7
*
I269, ,
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
+∞
7.4
7
*
SGA01, ,
ICD-O-3
+∞
7.4
7
*
R104, ,
ICD-O-3
+∞
7.4
7
*
N03AX12, ,
ATC
[U] gabapentin; oral
+∞
7.4
7
*
SPAT1148, ,
ICD-O-3
+∞
7.4
7
*
J450, ,
ICD-10 Finland
Predominantly allergic asthma
+∞
7.4
7
*
L01AA03, ,
ATC
melphalan; systemic
+∞
7.4
7
*
L82, ,
ICD-O-3
+∞
7.4
7
*
SPAT1230, ,
ICD-O-3
+∞
7.4
7
*
H258, ,
ICD-10 Finland
Other senile cataract
+∞
7.4
7
*
TQW40, ,
ICD-O-3
+∞
7.4
7
*
NA1AA, ,
ICD-O-3
+∞
7.4
7
*
K0366, ,
ICD-O-3
+∞
7.4
7
*
D10AX03, ,
ATC
azelaic acid; topical
+∞
7.4
7
*
S29, ,
ICD-O-3
+∞
7.4
7
*
T90, ,
ICD-O-3
+∞
7.4
7
*
R07, ,
ICD-O-3
+∞
7.4
7
*
P01BA02, ,
ATC
hydroxychloroquine; oral
+∞
7.4
7
*
R03AK06, ,
ATC
salmeterol and fluticasone; inhalant
+∞
7.4
7
*
R103, ,
ICD-O-3
+∞
7.4
7
*
N189, ,
ICD-10 Finland
Chronic kidney disease, unspecified
+∞
7.4
7
*
SPAT1260, ,
ICD-O-3
+∞
7.4
7
*
N06AB03, ,
ATC
fluoxetine; oral
+∞
6.3
6
*
SHB00, ,
ICD-O-3
+∞
6.3
6
*
Z035, ,
ICD-10 Finland
Observation for other suspected cardiovascular diseases
+∞
6.3
6
*
WZC05, ,
ICD-O-3
+∞
6.3
6
*
D01AE16, ,
ATC
amorolfine; topical
+∞
6.3
6
*
D11, ,
ICD-O-3
+∞
6.3
6
*
Z048, ,
ICD-10 Finland
Examination and observation for other specified reasons
+∞
6.3
6
*
H02, ,
ICD-O-3
+∞
6.3
6
*
N300, ,
ICD-O-3
+∞
6.3
6
*
SJD10, ,
ICD-O-3
+∞
6.3
6
*
K210, ,
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
+∞
6.3
6
*
SGC10, ,
ICD-O-3
+∞
6.3
6
*
J010, ,
ICD-10 Finland
Acute maxillary sinusitis
+∞
6.3
6
*
UKC02, ,
ICD-O-3
+∞
6.3
6
*
WF049, ,
ICD-O-3
+∞
6.3
6
*
U02, ,
ICD-O-3
+∞
6.3
6
*
D07BA04, ,
ATC
hydrocortisone and antiseptics; topical
+∞
6.3
6
*
NA2AA, ,
ICD-O-3
+∞
6.3
6
*
J01FA15, ,
ATC
telithromycin; oral
+∞
6.3
6
*
AA1BG, ,
ICD-O-3
+∞
6.3
6
*
W19, ,
ICD-10 Finland
Unspecified fall
+∞
6.3
6
*
R509, ,
ICD-O-3
+∞
6.3
6
*
D649, ,
ICD-10 Finland
Anaemia, unspecified
+∞
6.3
6
*
153, ,
Kela drug reimbursment
Lenalidomid
+∞
6.3
6
*
TPH15, ,
ICD-O-3
+∞
6.3
6
*
L959, ,
ICD-10 Finland
Vasculitis limited to skin, unspecified
+∞
6.3
6
*
M139, ,
ICD-O-3
+∞
6.3
6
*
A04AA02, ,
ATC
granisetron; systemic, transdermal
+∞
6.3
6
*
K0510, ,
ICD-O-3
+∞
6.3
6
*
J310, ,
ICD-10 Finland
Chronic rhinitis
+∞
6.3
6
*
SGA04, ,
ICD-O-3
+∞
6.3
6
*
R101, ,
ICD-O-3
+∞
6.3
6
*
R238, ,
ICD-O-3
+∞
6.3
6
*
C03DA01, ,
ATC
spironolactone; oral
+∞
6.3
6
*
WZC30, ,
ICD-O-3
+∞
6.3
6
*
J01AA07, ,
ATC
tetracycline; systemic
+∞
6.3
6
*
F419, ,
ICD-10 Finland
Anxiety disorder, unspecified
+∞
6.3
6
*
SXC05, ,
ICD-O-3
+∞
6.3
6
*
A28, ,
ICD-O-3
+∞
6.3
6
*
A01, ,
ICD-O-3
+∞
6.3
6
*
R065, ,
ICD-10 Finland
Mouth breathing
+∞
6.3
6
*
SGB10, ,
ICD-O-3
+∞
6.3
6
*
FB1BD, ,
ICD-O-3
+∞
6.3
6
*
UDQ12, ,
ICD-O-3
+∞
6.3
6
*
203, ,
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
+∞
6.3
6
*
B03XA02, ,
ATC
darbepoetin alfa; parenteral
+∞
6.3
6
*
M549, ,
ICD-10 Finland
Dorsalgia, unspecified
+∞
6.3
6
*
Z961, ,
ICD-10 Finland
Presence of intraocular lens
+∞
6.3
6
*
SAB03, ,
ICD-O-3
+∞
6.3
6
*
J01DA08, ,
ATC
[U] cefaclor
+∞
6.3
6
*
J159, ,
ICD-10 Finland
Bacterial pneumonia, unspecified
+∞
6.3
6
*
D07BB04, ,
ATC
hydrocortisone butyrate and antiseptics; topical
+∞
6.3
6
*
R01AD05, ,
ATC
budesonide; nasal
+∞
6.3
6
*
Z515, ,
ICD-10 Finland
Palliative care
+∞
6.3
6
*
R01AC01, ,
ATC
cromoglicic acid; nasal
+∞
6.3
6
*
EB1CA, ,
ICD-O-3
+∞
6.3
6
*
SPAT1211, ,
ICD-O-3
+∞
6.3
6
*
V252A, ,
ICD-9 Finland
Contraceptive management, Sterilisation
+∞
6.3
6
*
N02AE01, ,
ATC
buprenorphine; parenteral, sublingual, transdermal
+∞
6.3
6
*
G459, ,
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
+∞
6.3
6
*
D06AX01, ,
ATC
fusidic acid; topical
+∞
6.3
6
*
SHA01, ,
ICD-O-3
+∞
6.3
6
*
K041, ,
ICD-O-3
+∞
6.3
6
*
EB1VA, ,
ICD-O-3
+∞
6.3
6
*
E000006, ,
ATC
+∞
6.3
6
*
D07CC01, ,
ATC
betamethasone and antibiotics; topical
+∞
6.3
6
*
B03BA03, ,
ATC
hydroxocobalamin; parenteral
+∞
6.3
6
*
K045, ,
ICD-10 Finland
Chronic apical periodontitis
+∞
6.3
6
*
R55, ,
ICD-10 Finland
Syncope and collapse
+∞
6.3
6
*
K409, ,
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
+∞
6.3
6
*
A01AB09, ,
ATC
miconazole; local oral
+∞
6.3
6
*
OAB48, ,
ICD-O-3
+∞
6.3
6
*
H13, ,
ICD-O-3
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
31
39
12.63
24.96
1.8
1.5
571.43
430.00
titre
—
7
8
24
23
14.60
14.03
9.5
3.0
—
—
—
0
0
20
17
15.42
12.21
1.5
1.1
0.23
0.23
g/l
0.09
20
17
20
17
15.42
12.21
1.5
1.2
1.23
1.15
g/l
0.35
20
17
50
238
4.14
8.40
12.1
6.3
—
—
—
0
0
12
8
17.44
8.01
5.4
1.1
—
—
—
0
0
35
138
3.82
7.58
4.2
1.3
2.81
2.18
g/l
1.23
27
72
7
0
+∞
7.40
2.7
0.0
—
—
—
0
0
13
17
8.95
6.43
9.4
4.4
24.05
25.56
mmol/l
0.96
13
17
6
0
+∞
6.33
1.2
0.0
—
—
—
0
0
14
22
7.52
6.20
10.5
5.2
—
—
—
0
0
17
36
5.76
6.08
2.9
2.7
72.92
64.03
e9/l
0.45
12
24
33
143
3.29
5.93
10.0
6.4
—
—
—
0
0
16
44
4.33
5.54
1.3
1.4
—
—
—
0
0
9
8
12.52
5.44
1.4
1.1
—
—
—
0
0
22
81
3.40
5.04
1.8
1.4
—
—
—
0
0
11
21
5.92
4.33
1.5
1.8
1.32
1.76
g/l
0.55
11
15
7
8
9.47
3.86
15.9
5.1
—
—
—
0
0
34
182
2.55
3.84
9.2
3.2
30.51
52.58
e6/l
0.60
29
141
6
5
12.84
3.83
1.7
1.2
—
—
—
0
0
11
25
4.95
3.79
1.2
1.2
—
—
—
0
0
44
271
2.46
3.63
26.2
6.1
1.22
1.22
mmol/l
0.02
36
230
18
72
2.96
3.52
2.7
1.8
—
—
—
0
0
7
10
7.56
3.44
1.3
1.4
—
—
—
0
0
27
138
2.47
3.28
6.5
4.0
—
—
—
0
0
17
71
2.79
3.06
4.4
2.2
—
—
—
0
0
9
23
4.29
2.88
1.1
1.8
—
—
—
0
0
29
163
2.25
2.79
9.5
3.1
—
—
—
0
0
13
49
2.99
2.79
8.7
8.0
—
—
—
0
0
35
214
2.17
2.73
12.1
3.5
17.17
84.04
e6/l
1.41
29
150
29
165
2.22
2.70
9.7
3.0
0.21
0.43
e6/l
0.62
23
125
40
262
2.10
2.58
14.1
9.4
0.00
0.01
e9/l
0.56
35
206
12
46
2.91
2.49
28.9
3.9
—
—
—
0
0
5
8
6.59
2.41
1.2
1.0
—
—
—
0
0
10
34
3.22
2.38
1.1
1.4
—
—
—
0
0
22
117
2.23
2.37
1.9
1.5
—
—
—
0
0
23
126
2.18
2.31
7.9
2.7
2.95
5.68
e6/l
1.54
23
116
5
9
5.85
2.25
1.0
1.0
—
—
—
0
0
5
9
5.85
2.25
1.6
1.1
124.60
757.19
ug/l
—
5
9
27
161
2.04
2.17
5.0
3.0
198.00
489.11
mg/l
0.32
22
102
5
10
5.26
2.10
1.0
1.0
—
—
—
0
0
5
10
5.26
2.10
1.4
1.4
—
—
—
0
0
5
11
4.78
1.97
1.2
1.0
—
—
—
0
0
15
75
2.24
1.85
1.7
1.7
—
—
—
0
0
23
137
1.97
1.82
6.7
2.6
—
—
—
0
0
22
129
1.99
1.82
9.5
3.0
614.05
559.21
mosm/kgh2o
0.54
22
113
26
162
1.91
1.81
9.7
4.6
7.40
7.40
ph
—
5
40
9
36
2.69
1.81
10.2
5.7
24.09
24.35
mmol/l
—
9
36
5
13
4.03
1.74
1.6
3.7
—
—
—
0
0
52
407
1.86
1.72
11.5
3.6
—
—
—
0
0
13
65
2.20
1.60
1.3
1.1
—
—
—
0
0
35
248
1.75
1.58
5.7
2.7
5.70
5.97
ph
—
5
20
23
144
1.85
1.55
2.1
2.0
—
—
—
0
0
5
15
3.49
1.55
1.2
1.3
—
—
—
0
0
6
22
2.87
1.46
1.3
3.2
18.50
36.11
u/ml
—
6
22
5
16
3.27
1.46
11.8
9.0
10.34
8.81
kpa
—
5
16
40
300
1.69
1.44
6.0
3.2
0.00
0.00
estimate
—
5
53
25
165
1.76
1.42
6.0
2.3
—
—
—
0
0
6
23
2.74
1.39
1.7
1.7
—
—
—
0
0
6
23
2.74
1.39
2.2
2.0
—
—
—
0
0
39
297
1.63
1.28
6.1
3.2
0.00
0.00
estimate
—
5
60
39
301
1.60
1.19
9.6
4.4
0.00
0.00
estimate
—
5
59
5
20
2.60
1.17
1.0
1.2
—
—
—
0
0
8
40
2.11
1.16
4.3
2.6
—
—
—
0
0
31
237
1.52
0.94
20.2
11.4
1.84
1.37
inr
—
8
73
47
392
1.51
0.94
5.5
3.9
—
23.80
—
0
5
22
156
1.57
0.93
1.4
1.3
4.59
1.26
u/ml
—
9
38
8
45
1.87
0.87
1.1
1.4
—
—
—
0
0
50
555
0.72
0.63
6.4
4.1
5.73
5.91
mmol/l
0.58
45
507
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
13
94
1.46
0.50
1.6
1.6
1273.88
1209.63
nmol/l
—
8
71
10
68
1.54
0.50
1.6
1.3
—
—
—
0
0
63
590
1.37
0.43
38.6
12.3
16.74
25.04
mg/l
2.25
55
443
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
9
65
1.43
0.40
4.6
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
2.2
—
—
—
0
0
9
69
1.34
0.39
1.1
1.2
—
—
—
0
0
51
549
0.79
0.37
4.8
4.0
1.34
1.47
mmol/l
1.21
46
508
51
548
0.79
0.36
5.3
4.3
1.98
1.88
mu/l
0.31
46
498
13
101
1.35
0.34
2.5
3.4
16.14
296.18
ng/l
—
7
75
63
597
1.30
0.33
33.4
13.8
139.16
139.62
mmol/l
0.93
58
579
63
597
1.30
0.33
34.5
13.9
3.95
3.95
mmol/l
0.02
58
579
7
56
1.27
0.30
1.1
1.1
—
—
—
0
0
21
179
1.24
0.29
5.6
3.1
—
—
—
0
0
49
518
0.85
0.22
6.2
5.4
37.26
39.84
mmol/mol
1.74
44
483
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
3.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
3.0
—
62.46
—
0
10
60
623
0.83
0.20
40.1
14.3
91.90
76.44
umol/l
0.70
60
623
50
526
0.86
0.20
5.0
3.7
1.63
1.26
mmol/l
1.55
45
488
6
51
1.19
0.20
1.3
1.2
—
—
—
0
0
66
679
0.80
0.19
46.4
17.2
39.48
40.05
%
0.41
61
641
43
450
0.90
0.13
4.6
3.6
14.46
14.99
pmol/l
0.68
38
406
22
203
1.12
0.11
2.7
1.8
71.74
95.00
pmol/l
2.44
14
102
5
44
1.15
0.10
3.8
5.5
97.92
94.91
%
—
5
44
10
88
1.16
0.08
1.5
1.7
—
—
—
0
0
18
167
1.10
0.07
4.0
3.3
—
—
—
0
0
16
173
0.91
0.07
1.4
1.4
—
—
—
0
0
64
629
1.10
0.06
31.3
11.2
—
—
—
0
0
18
191
0.92
0.05
2.3
3.0
—
—
—
0
0
16
152
1.07
0.02
4.7
4.0
—
—
—
0
0
15
156
0.95
0.00
5.8
3.3
0.00
0.02
estimate
—
5
55
22
214
1.04
0.00
2.3
2.1
—
—
—
0
0
22
214
1.04
0.00
5.2
3.3
289.16
35.30
ng/l
0.77
17
145
38
375
1.03
0.00
3.2
3.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
3.3
—
87.86
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
6
63
0.95
-0.00
8.5
5.6
103.33
103.95
mmol/l
—
6
63
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
51
0.98
-0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
28.67
—
0
6
0
7
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
52
0.96
-0.00
1.4
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
6.75
—
0
6
0
7
0.00
-0.00
0.0
2.7
—
2.80
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint SYSTINOTH_FG and mortality.

Females

Parameter HR [95% CI] p-value
SYSTINOTH_FG 6.501 [4.18, 10.11] < 0.001
Birth year 0.999 [0.99, 1.01] 0.748

During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 452 females with SYSTINOTH_FG died.

Males

Parameter HR [95% CI] p-value
SYSTINOTH_FG 4.561 [2.89, 7.19] < 0.001
Birth year 0.99 [0.98, 1.0] 0.024

During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 560 males with SYSTINOTH_FG died.

Mortality risk

Mortality risk for people of age

years, who have SYSTINOTH_FG.

N-year risk Females Males
1 0.869% 0.862%
5 4.764% 5.226%
10 10.807% 12.795%
15 18.419% 24.153%
20 30.062% 38.855%

Relationships between endpoints

Index endpoint: SYSTINOTH_FG – Systemic disorders of connective tissue in diseases classified elsewhere (FG)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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