connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.
Systemic disorders of connective tissue in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
M13_SYSTCONINOTH
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
166 |
4. Check minimum number of eventsNone |
166 |
5. Include endpointsNone |
166 |
6. Filter based on genotype QC (FinnGen only) |
143 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Systemic disorders of connective tissue in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1422 | 617 | 803 |
| Only index persons | 1167 | 513 | 654 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 25.39 | 30.73 | 21.29 |
| Only index persons | 30.58 | 35.25 | 26.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 143 | 71 | 72 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 49.18 | 52.64 | 45.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 145
- Matched controls
- 1450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M36.4*D69.0
ICD-10 Finland
Arthropathy in Henoch(-Schönlein) purpura
+∞
52.3
47
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
14.0
39.7
42
41
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
34.8
32
*
126
Kela drug reimbursment
Chronic coagulation defects
393.0
32.2
31
*
ZX120
NOMESCO Finland
Intravenous
8.8
30.4
47
75
D66
ICD-10 Finland
Hereditary factor VIII deficiency
+∞
30.3
28
*
D69.0
ICD-10 Finland
Allergic purpura
130.3
30.0
31
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
28.0
26
*
B02BD02
ATC
coagulation factor VIII; parenteral
+∞
24.7
23
*
M362, D66,
ICD-10 Finland
+∞
24.7
23
*
B02AA02
ATC
tranexamic acid; systemic
6.6
22.4
45
93
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.0
20.8
80
288
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
7.3
19.7
33
56
M36.1*C90.0
ICD-10 Finland
Arthropathy in multiple myeloma
+∞
19.2
18
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
7.0
18.5
32
56
J01MA12
ATC
levofloxacin; systemic
5.2
18.4
50
134
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
18.1
17
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
18.1
17
*
B02BX06
ATC
emicizumab; parenteral
+∞
17.0
16
*
2860A
ICD-9 Finland
Coagulation defects, Congenital factor VIII disorder
+∞
17.0
16
*
28600
ICD-8 Finland
Coagulation defects, Haemophilia
+∞
17.0
16
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.1
15.6
40
101
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
14.8
14
*
3047, ,
Kela drug reimbursment
+∞
14.8
14
*
1520, ,
Kela drug reimbursment
+∞
14.8
14
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
14.8
14
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.1
14.0
54
185
6BA02, ,
NOMESCO Finland
82.8
13.9
15
*
C90.0
ICD-10 Finland
Multiple myeloma
38.2
13.8
17
5
R50.9
ICD-10 Finland
Fever, unspecified
4.3
13.8
47
147
M36.2
ICD-10 Finland
Haemophilic arthropathy
+∞
13.8
13
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
12.8
13.6
24
22
H02AB07
ATC
prednisone; oral
4.7
13.0
36
96
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
5.6
12.7
27
57
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
12.7
12
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.7
12.2
21
36
B18.2
ICD-10 Finland
Chronic viral hepatitis C
21.2
11.9
17
9
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
33.2
11.9
15
5
H02AB06
ATC
prednisolone; systemic
3.4
11.6
86
439
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
10.6
11.5
22
24
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.5
11.2
54
211
R4110
NOMESCO Finland
Physiotherapy
3.3
11.1
62
266
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
118.2
10.6
11
*
M05BA04
ATC
alendronic acid; oral
5.7
10.4
21
42
Z3226
NOMESCO Finland
Physiotherapist
3.5
10.1
45
166
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.9
10.0
24
56
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
5.1
10.0
23
52
ZXA05
NOMESCO Finland
Left side
3.3
9.9
49
193
N02AX02
ATC
tramadol; systemic, rectal
3.0
9.8
72
356
M19.2
ICD-10 Finland
Other secondary arthrosis
32.4
9.6
12
*
ZXD10
NOMESCO Finland
Scheduled procedure
3.0
9.5
71
353
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
5.6
9.4
19
38
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.1
9.2
29
84
J01FF01
ATC
clindamycin; systemic
3.1
9.2
54
234
M13.9
ICD-10 Finland
Arthritis, unspecified
5.1
9.2
21
47
ZX121
NOMESCO Finland
Central venous catheter
39.3
9.2
11
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.3
8.9
19
40
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
7.6
8.7
20
30
M36.4
ICD-10 Finland
Arthropathy in hypersensitivity reactions classified elsewhere
+∞
8.4
8
*
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
8.4
8
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.8
8.3
29
90
TPX10
NOMESCO Finland
Implantation of vascular injection port
9.8
8.3
16
18
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
12.8
8.3
14
12
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.6
8.1
21
52
Z2221
NOMESCO Finland
Medical doctor
2.9
8.1
53
242
C01CA24
ATC
epinephrine; parenteral
4.5
7.9
21
53
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
16.2
7.9
12
8
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
7.7
79
450
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
26.6
7.7
10
*
XF400
NOMESCO Finland
ECG with 12 standard connections
3.3
7.6
33
118
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.8
7.5
18
42
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.9
7.4
17
38
J47
ICD-10 Finland
Bronchiectasis
16.9
7.4
11
7
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
+∞
7.3
7
*
NHG20
NOMESCO Finland
Fusion of talocrural joint
+∞
7.3
7
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
7.3
7
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
7.3
7
*
ZXA00
NOMESCO Finland
Right side
2.8
7.3
49
225
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
7.2
65
345
J01DA06
ATC
[U] cefuroxime
3.3
7.2
30
105
L04AX01
ATC
azathioprine; systemic
8.2
7.1
15
20
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.5
7.0
18
44
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
7.4
7.0
16
24
Z3231
NOMESCO Finland
Registered nurse
2.7
7.0
54
265
N17.9
ICD-10 Finland
Acute renal failure, unspecified
9.0
7.0
14
17
TDM10
NOMESCO Finland
Puncture of maxillary antrum
7.1
6.9
16
25
M05BA02
ATC
clodronic acid; systemic
23.8
6.8
9
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.7
6.7
23
70
NF1AA
NOMESCO Finland
Hip X-ray examination
4.1
6.7
20
55
N03AX16
ATC
[U] pregabalin
2.8
6.7
40
172
R01BA52
ATC
pseudoephedrine, combinations; oral
2.7
6.6
48
228
A02BC02
ATC
pantoprazole; systemic
2.6
6.6
102
690
EBA10
NOMESCO Finland
Operative extraction of tooth
3.0
6.5
34
135
XW000
NOMESCO Finland
Bone marrow biopsy
7.1
6.5
15
23
L04AX04
ATC
lenalidomide; oral
72.9
6.5
7
*
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
11.8
6.4
11
10
N02AA05
ATC
oxycodone; systemic
2.9
6.3
35
144
Z2446
NOMESCO Finland
Social worker
4.1
6.3
18
48
M15.3
ICD-10 Finland
Secondary multiple arthrosis
+∞
6.3
6
*
2BD02, ,
NOMESCO Finland
+∞
6.3
6
*
D67
ICD-10 Finland
Hereditary factor IX deficiency
+∞
6.3
6
*
C03CA01
ATC
furosemide; systemic
2.6
6.3
48
233
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.5
6.3
16
39
H02AB09
ATC
hydrocortisone; systemic
9.2
6.2
12
14
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
9.2
6.2
12
14
J01MA14
ATC
moxifloxacin; systemic
3.6
6.2
22
69
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
6.1
41
186
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.8
6.1
20
59
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
6.1
33
134
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.5
6.0
22
70
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
33
39
10.66
26.88
1.5
1.1
0.23
0.23
g/l
0.16
33
39
33
40
10.39
26.37
1.5
1.2
1.20
1.16
g/l
0.27
33
40
47
126
5.04
17.17
6.1
4.8
216.45
244.65
u/l
1.28
47
121
25
39
7.54
15.95
1.6
1.3
3.40
7.90
iu/ml
—
5
9
40
103
4.98
15.19
6.8
2.2
0.22
0.21
g/l
0.15
40
94
33
75
5.40
14.43
4.0
1.4
—
—
—
0
0
70
295
3.65
13.29
4.1
2.0
2.85
2.85
mg/l
0.01
63
254
15
5
33.16
11.90
7.1
1.8
681.73
1319.60
u/ml
—
15
5
22
23
11.06
11.74
1.3
1.2
1.44
10.00
u/ml
—
9
8
15
6
27.63
11.39
1.6
2.0
111.80
105.67
%
—
15
6
33
92
4.35
11.13
4.9
3.3
85.65
62.60
ml/min/173m2
2.61
23
42
116
723
4.02
11.11
24.1
10.3
4.13
4.03
e9/l
0.21
107
621
20
36
6.28
11.04
3.3
1.6
—
—
—
0
0
21
24
10.03
10.71
1.3
1.2
2.14
6.00
u/ml
0.71
14
12
10
0
+∞
10.54
3.2
0.0
—
—
—
0
0
21
26
9.25
10.26
1.2
1.0
—
—
—
0
0
18
37
5.41
8.62
3.6
1.6
—
—
—
0
0
74
394
2.79
8.50
5.6
3.1
2.33
2.36
mmol/l
0.90
69
359
95
584
2.82
8.11
22.2
7.8
1.21
1.21
mmol/l
0.45
81
510
20
34
6.65
8.03
2.9
1.6
—
—
—
0
0
17
24
7.87
7.74
3.6
1.7
—
—
—
0
0
24
69
3.97
7.65
9.9
7.4
0.76
0.98
mmol/l
0.09
19
51
12
9
14.39
7.53
1.3
1.4
13.48
14.33
umol/l
—
12
9
17
28
6.73
7.02
3.3
1.9
13.46
11.26
mg/l
0.54
17
28
18
33
6.07
6.88
2.4
1.4
—
—
—
0
0
15
23
7.14
6.53
1.3
1.2
—
—
—
0
0
10
7
15.21
6.50
1.8
7.1
1053.10
498.00
mg
—
10
7
13
16
8.80
6.49
6.8
1.6
—
—
—
0
0
11
10
11.78
6.41
2.5
3.0
11.36
9.30
%
—
11
10
13
17
8.28
6.28
6.8
1.6
—
—
—
0
0
24
81
3.35
6.02
11.9
6.8
5.01
5.02
kpa
0.01
24
81
9
6
15.86
5.98
4.4
1.0
—
—
—
0
0
11
12
9.81
5.90
4.5
2.0
—
—
—
0
0
11
12
9.81
5.90
4.5
2.0
—
—
—
0
0
11
12
9.81
5.90
4.5
2.0
—
—
—
0
0
15
27
6.07
5.87
10.0
2.6
1.26
1.41
ratio
—
9
11
14
23
6.61
5.86
1.4
1.5
—
—
—
0
0
14
23
6.61
5.86
1.4
1.5
—
—
—
0
0
9
7
13.59
5.66
4.4
1.1
—
—
—
0
0
62
353
2.32
5.63
9.6
3.3
0.12
0.36
e6/l
1.89
46
254
15
31
5.27
5.29
5.1
1.5
—
—
—
0
0
44
222
2.41
5.20
6.9
2.9
0.63
0.90
e6/l
0.45
24
113
42
208
2.43
5.16
7.5
2.9
1.82
2.80
e6/l
0.45
22
100
10
12
8.85
5.15
6.7
1.7
—
—
—
0
0
10
12
8.85
5.15
6.7
1.7
—
—
—
0
0
10
12
8.85
5.15
6.7
1.7
—
—
—
0
0
10
12
8.85
5.15
6.7
1.7
—
—
—
0
0
41
202
2.44
5.09
4.2
1.6
—
—
—
0
0
52
286
2.28
5.02
6.0
2.0
1.00
1.34
mg/l
0.57
45
223
10
13
8.17
4.94
6.7
1.6
—
—
—
0
0
10
13
8.17
4.94
6.7
1.6
—
—
—
0
0
9
11
8.63
4.63
2.0
3.1
—
—
—
0
0
7
5
14.60
4.62
1.6
1.2
—
—
—
0
0
51
290
2.17
4.46
4.9
2.3
—
—
—
0
0
14
33
4.58
4.46
6.6
1.9
—
—
—
0
0
14
34
4.44
4.34
5.4
1.7
—
—
—
0
0
8
9
9.32
4.33
1.5
1.1
—
—
—
0
0
8
9
9.32
4.33
1.5
1.1
—
—
—
0
0
8
9
9.32
4.33
1.5
1.1
—
—
—
0
0
8
9
9.32
4.33
1.5
1.1
—
—
—
0
0
8
9
9.32
4.33
1.5
1.1
—
—
—
0
0
17
57
3.25
4.28
8.0
6.5
1.55
1.28
mg/l
0.38
17
52
8
10
8.39
4.11
1.5
1.1
—
—
—
0
0
32
155
2.37
4.06
2.3
1.5
—
—
—
0
0
9
14
6.77
4.05
1.3
1.6
—
—
—
0
0
9
14
6.77
4.05
1.1
1.0
—
—
—
0
0
9
15
6.32
3.88
1.6
1.2
—
—
—
0
0
6
5
12.43
3.79
2.5
2.0
—
—
—
0
0
6
5
12.43
3.79
2.5
2.0
—
—
—
0
0
11
25
4.67
3.71
1.3
1.1
—
—
—
0
0
10
24
4.39
3.26
1.4
1.6
—
—
—
0
0
6
8
7.76
3.08
1.3
1.1
—
—
—
0
0
6
8
7.76
3.08
8.0
1.8
-3.23
0.04
mmol/l
—
6
8
5
5
10.29
3.00
2.2
2.2
141.20
62.38
ug/l
—
5
5
10
27
3.90
2.94
1.6
2.2
—
—
—
0
0
14
53
2.82
2.89
1.6
1.3
—
—
—
0
0
12
42
3.02
2.62
1.2
1.3
—
—
—
0
0
85
657
1.71
2.54
5.6
3.8
0.00
0.00
estimate
-0.00
17
125
15
64
2.50
2.48
2.5
1.5
—
—
—
0
0
18
84
2.30
2.47
23.4
6.4
24.24
24.32
mmol/l
0.04
18
84
6
12
5.16
2.42
1.3
1.1
—
—
—
0
0
28
159
1.94
2.35
16.8
8.5
104.11
104.48
mmol/l
0.14
28
159
8
23
3.62
2.30
1.0
1.2
—
—
—
0
0
83
648
1.66
2.30
5.6
3.7
0.00
0.00
estimate
-0.00
17
130
9
29
3.24
2.27
1.3
1.8
—
—
—
0
0
83
650
1.65
2.25
5.7
3.7
0.00
0.00
estimate
-0.00
17
130
20
102
2.11
2.23
2.9
4.0
—
—
—
0
0
7
20
3.62
2.08
1.1
1.4
—
—
—
0
0
23
131
1.90
1.91
18.9
6.6
1.29
1.91
mmol/l
0.47
18
108
6
17
3.63
1.85
4.3
3.2
—
—
—
0
0
6
17
3.63
1.85
1.2
1.8
—
—
—
0
0
31
197
1.73
1.82
1.3
1.3
1.39
8.18
u/ml
—
10
78
6
18
3.43
1.76
1.2
1.2
—
—
—
0
0
6
18
3.43
1.76
1.3
1.6
—
—
—
0
0
25
151
1.79
1.74
2.2
1.6
—
—
—
0
0
46
331
1.57
1.67
1.3
1.3
2.96
1.77
u/ml
0.24
15
84
8
32
2.59
1.62
1.1
1.7
—
—
—
0
0
32
212
1.65
1.62
1.4
1.3
15.37
30.80
iu/ml
—
6
68
7
26
2.78
1.60
1.1
1.7
—
—
—
0
0
48
353
1.54
1.58
4.5
3.8
0.00
0.01
estimate
0.50
15
119
22
132
1.79
1.57
6.8
7.4
11.73
12.74
kpa
0.49
22
126
22
132
1.79
1.57
6.9
7.4
4.87
5.04
kpa
0.32
22
125
5
15
3.41
1.53
1.0
1.3
—
—
—
0
0
6
21
2.93
1.52
1.2
2.0
—
—
—
0
0
9
40
2.33
1.43
3.3
2.3
—
—
—
0
0
9
41
2.27
1.40
1.3
1.6
345.78
508.20
mg/l
—
9
41
12
62
2.02
1.32
1.4
1.3
—
—
—
0
0
103
1138
0.67
1.29
5.5
4.6
6.05
5.91
mmol/l
0.34
96
1054
14
78
1.88
1.26
6.7
10.3
94.84
94.35
%
0.22
14
78
6
25
2.46
1.25
2.0
1.2
—
—
—
0
0
7
34
2.11
1.04
1.0
1.2
—
—
—
0
0
31
228
1.46
1.00
2.5
3.3
23.67
384.83
ng/l
1.76
21
167
47
375
1.37
0.97
5.7
4.2
18.46
11.44
mg/mmol
0.35
36
245
6
31
1.97
0.85
1.2
1.4
—
—
—
0
0
122
1142
1.43
0.80
31.7
13.7
89.94
85.82
ml/min/173m2
1.05
115
1042
0
24
0.00
0.80
0.0
1.5
—
56.57
—
0
24
58
492
1.30
0.77
2.7
2.0
90.97
95.76
pmol/l
0.32
39
247
65
563
1.28
0.73
5.1
2.7
—
—
estimate
—
0
0
35
285
1.30
0.62
1.9
1.8
—
—
—
0
0
128
1222
1.40
0.60
43.9
14.0
18.64
23.37
mg/l
1.26
116
994
6
35
1.74
0.58
1.0
1.2
—
—
—
0
0
8
55
1.48
0.57
5.2
3.5
9.00
3629.31
u/ml
—
8
48
11
75
1.50
0.52
1.1
1.0
—
—
—
0
0
10
69
1.48
0.45
28.9
6.0
0.37
0.62
%
—
10
69
106
1112
0.83
0.41
5.7
5.1
1.98
1.83
mu/l
0.73
101
1030
13
101
1.32
0.33
4.2
2.6
0.82
1.01
e6/l
0.06
13
95
114
1177
0.85
0.28
5.6
5.4
2.83
2.71
mmol/l
0.55
109
1096
113
1166
0.86
0.26
5.2
4.7
4.62
4.59
mmol/l
0.08
108
1085
26
227
1.18
0.26
2.6
2.9
0.68
0.75
ug/l
0.28
17
136
12
97
1.26
0.23
1.6
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
4.00
—
0
5
0
12
0.00
0.21
0.0
3.8
—
0.92
—
0
12
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
113
1160
0.88
0.20
5.1
4.6
1.36
1.43
mmol/l
1.18
107
1077
13
110
1.20
0.18
1.5
2.4
—
—
—
0
0
47
442
1.09
0.16
5.2
3.5
112.66
33.69
ng/l
0.59
36
302
108
1055
1.09
0.14
41.5
17.9
13.87
13.52
%
1.48
108
1047
28
303
0.91
0.14
4.9
3.4
1.02
1.02
kg/l
1.17
19
187
11
95
1.17
0.12
1.9
1.3
—
—
—
0
0
108
1099
0.93
0.10
4.6
4.0
1.45
1.30
mmol/l
1.01
101
1015
28
298
0.93
0.09
3.5
4.2
22.18
22.51
%
0.05
17
125
6
53
1.14
0.09
1.3
1.2
1.48
1.56
g/l
—
6
53
6
55
1.09
0.09
1.2
1.2
0.91
0.91
g/l
—
6
55
8
74
1.09
0.07
1.0
1.4
—
—
—
0
0
15
163
0.91
0.07
1.6
1.8
1.54
1.38
%
—
10
152
18
191
0.93
0.05
1.8
2.7
—
—
—
0
0
48
492
0.96
0.04
4.6
3.6
0.00
0.00
estimate
-0.00
15
113
17
178
0.95
0.02
1.7
2.5
—
—
—
0
0
16
167
0.95
0.01
1.5
1.4
—
—
—
0
0
86
854
1.02
0.00
4.0
3.4
—
—
—
0
0
12
124
0.96
0.00
12.4
7.0
—
—
—
0
0
35
353
0.99
0.00
3.7
3.2
0.00
0.00
estimate
-0.00
14
108
92
925
0.99
0.00
4.8
4.2
14.44
14.85
pmol/l
0.81
85
848
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
7
69
1.02
0.00
4.1
5.9
23.11
24.10
mmol/l
—
7
64
0
6
0.00
0.00
0.0
5.3
—
210.67
—
0
6
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
0.07
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
110.86
—
0
7
0
5
0.00
-0.00
0.0
1.6
—
17.98
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
0.28
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
42.80
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYSTCONINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTCONINOTH | 5.224 [3.7, 7.37] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 126 out of 560 females with M13_SYSTCONINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTCONINOTH | 3.748 [2.61, 5.38] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 723 males with M13_SYSTCONINOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYSTCONINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.508% | 0.623% |
| 5 | 2.696% | 4.136% |
| 10 | 6.368% | 10.073% |
| 15 | 12.205% | 18.83% |
| 20 | 21.608% | 30.435% |
Relationships between endpoints
↥Index endpoint: M13_SYSTCONINOTH – Systemic disorders of connective tissue in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data