Crushing injury of ankle and foot

ST19_CRUSHI_INJURY_ANKLE_FOOT

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — S97 Cause of death: ICD-10 — S97 2 out of 7 registries used, show all original rules.	142
4. Check minimum number of events None	142
5. Include endpoints None	142
6. Filter based on genotype QC (FinnGen only)	136

Control definitions (FinnGen only)

Control exclude: ST19_INJURI_ANKLE_FOOT

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: S90
Name in latin: Conquassatio tarsi/pedis

NAME	ST19_CRUSHI_INJURY_ANKLE_FOOT
CONTROL_EXCLUDE	ST19_INJURI_ANKLE_FOOT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	S97
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	S97
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Crushing injury of ankle and foot based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	136	43	93
Unadjusted period prevalence (%)	0.03	0.02	0.04
Median age at first event (years)	50.09	48.81	50.68

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
138: Matched controls
1380

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

S97.8

ICD-10 Finland

Crushing injury of other parts of ankle and foot

+∞

72.4

S97.1

ICD-10 Finland

Crushing injury of toe(s)

+∞

48.9

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

15.9

38.4

S97.0

ICD-10 Finland

Crushing injury of ankle

+∞

32.6

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

8.5

24.4

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

25.1

23.6

NHJ50

NOMESCO Finland

Open reduction of fracture of foot or toe

+∞

18.1

NHQ40

NOMESCO Finland

Amputation of toe

28.7

18.1

X59

ICD-10 Finland

Exposure to unspecified factor

4.8

17.3

162

X58

ICD-10 Finland

Exposure to other specified factors

5.0

16.4

121

ZZA00

NOMESCO Finland

Split skin graft

20.4

16.3

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

7.4

16.1

W23

ICD-10 Finland

Caught, crushed, jammed or pinched in or between objects

48.1

14.5

SPAT1148

SPAT

Treatment of chronic ulcer or burn

4.7

13.8

111

T93.6

ICD-10 Finland

Sequelae of crushing injury and traumatic amputation of lower limb

+∞

13.8

QDE35

NOMESCO Finland

Repair of skin defect in lower limb after surgery or injury

154.6

13.7

NHU20

NOMESCO Finland

Removal of internal fixation device from ankle or foot

12.9

13.7

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

4.6

10.6

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

3.3

10.6

246

S92.7

ICD-10 Finland

Multiple fractures of foot

+∞

10.5

W31

ICD-10 Finland

Contact with other and unspecified machinery

12.0

10.1

A46

ICD-10 Finland

Erysipelas

3.7

9.6

119

ZXD05

NOMESCO Finland

Urgent procedure

3.1

9.5

266

S97

ICD-10 Finland

Crushing injury of ankle and foot

+∞

9.5

NH1AD

NOMESCO Finland

Ankle and foot CT

15.1

9.4

J01FF01

ATC

clindamycin; systemic

3.1

9.1

250

S92.5

ICD-10 Finland

Fracture of other toe

20.3

9.1

S92.0

ICD-10 Finland

Fracture of calcaneus

+∞

8.4

W22

ICD-10 Finland

Striking against or struck by other object(s)

4.8

8.0

QDG20

NOMESCO Finland

Operation for chronic ulcer or fistula of skin of lower limb

84.4

7.5

TNX92

NOMESCO Finland

Supporting bandage or orthosis of lower limb

31.8

7.2

WX213

NOMESCO Finland

Lower leg blockade

31.8

7.2

NHM99

NOMESCO Finland

Other operation on fascia, ganglion, synovial sheath or bursa of ankle or foot

42.2

6.8

S80.1

ICD-10 Finland

Contusion of other and unspecified parts of lower leg

8.8

6.5

NH3BA

NOMESCO Finland

Foot and toes extensive X-ray examination

8.8

6.5

J01CE08

ATC

benzathine benzylpenicillin; parenteral

73.1

6.5

NHQ30

NOMESCO Finland

Amputation of foot, transmetatarsal

73.1

6.5

TQW11

NOMESCO Finland

Vacuum treatment of wound

10.0

6.4

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.9

6.3

138

TNX34

NOMESCO Finland

Major custom molded cast, unspecified region

28.1

6.3

QDE20

NOMESCO Finland

Excision and repair of scar or web of skin of lower limb

+∞

6.3

NHG20

NOMESCO Finland

Fusion of talocrural joint

+∞

6.3

TNX33

NOMESCO Finland

Custom moulded cast, unspecified region

6.6

6.2

S92.3

ICD-10 Finland

Fracture of metatarsal bone

13.3

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

145

2.78

5.73

2.9

1.7

—

(3042936) Bacteria identified in Isolate by Culture

183

2.49

4.98

2.8

2.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

132

1146

4.49

4.64

22.8

15.7

26.75

25.07

mg/l

0.25

117

951

(3023368) Bacteria identified in Blood by Culture

334

2.14

4.38

4.7

4.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

135

2.35

3.59

2.2

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

130

2.34

3.47

2.1

2.0

—

(3044640) Blood type and Crossmatch panel - Blood

385

1.93

3.43

2.8

2.4

—

(3032080) INR in Blood by Coagulation assay

575

1.67

2.27

20.8

12.5

1.30

1.21

inr

0.74

478

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.83

2.26

2.4

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

187

1.85

2.18

2.7

2.0

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.07

2.02

2.5

3.1

24.50

39.25

u/l

1.11

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

720

1.61

1.92

3.2

3.1

—

(3015736) pH of Urine

499

1.57

1.84

4.1

3.7

6.16

6.19

0.08

301

(3012544) pH of Venous blood

119

1.90

1.78

2.2

3.4

7.40

7.38

0.96

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

284

1.63

1.77

2.8

2.3

—

(40758558) Short blood count panel - Blood

346

1.59

1.76

7.1

5.8

—

(3000494) Fungus identified in Specimen by Culture

135

1.84

1.76

1.3

1.5

—

(3000093) Morphology [Interpretation] in Blood Narrative

3.95

1.73

1.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.25

1.68

1.2

1.5

—

(3026008) Bacteria identified in Urine by Culture

323

1.58

1.67

4.0

3.0

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

119

1068

1.83

1.66

4.4

4.9

2.00

1.96

mu/l

0.12

107

980

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

100

860

1.59

1.63

5.1

4.0

12.87

10.90

mm/h

0.51

799

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

140

1.77

1.57

13.4

7.3

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.51

1.56

1.4

1.8

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.51

1.56

1.5

2.8

81.50

87.55

—

(3016879) Cocaine [Presence] in Urine

2.26

1.55

2.4

1.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

552

1.50

1.54

6.3

7.0

1.20

1.21

mmol/l

0.25

473

(3014576) Chloride [Moles/volume] in Serum or Plasma

149

1.74

1.54

7.4

6.9

103.29

104.04

mmol/l

0.29

149

(3011288) Drugs identified in Urine by Screen method Nominal

2.68

1.53

3.1

2.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

563

1.49

1.52

3.3

2.8

—

estimate

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.58

1.47

1.4

3.2

188.43

234.93

—

(3033658) Prothrombin time (PT) actual/Normal

279

1.55

1.45

4.7

4.3

89.26

89.01

0.02

274

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.80

1.45

1.3

2.1

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.80

1.45

1.7

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

123

1129

1.82

1.38

17.7

14.7

85.14

83.47

ml/min/173m2

0.38

114

1048

(3003396) Base excess in Arterial blood by calculation

139

1.69

1.33

7.6

7.5

2.21

0.64

mmol/l

1.60

114

(3016502) Oxygen saturation in Arterial blood

131

1.71

1.33

7.8

7.6

95.67

95.43

0.07

125

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.43

1.31

1.3

2.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.09

1.31

1.5

1.7

—

(3027008) Opiates [Presence] in Urine

2.09

1.31

2.4

1.5

—

(44790048) Parainfluenza type 2 nucleic acid detection

2.84

1.29

1.2

1.6

—

(44790049) Parainfluenza type 3 nucleic acid detection

2.84

1.29

1.2

1.6

—

(44790047) Parainfluenza type 1 nucleic acid detection

2.84

1.29

1.2

1.6

—

(44806118) Parainfluenza type 4 nucleic acid detection

2.84

1.29

1.2

1.6

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

489

1.44

1.29

2.2

2.4

72.43

73.08

nmol/l

0.07

429

(3002582) Erythrocytes [#/volume] in Urine

387

1.46

1.27

3.2

18.93

212.07

e6/l

0.58

287

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

500

1.44

1.27

2.2

2.0

94.75

95.08

pmol/l

0.02

251

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

133

1.68

1.26

3.9

3.3

—

(3027944) Amphetamines [Presence] in Urine

2.05

1.26

2.4

1.6

—

(3028300) Cannabinoids [Presence] in Urine

2.05

1.26

2.4

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

2.05

1.26

2.4

1.6

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.46

1.25

1.7

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

648

1.43

1.23

5.6

7.1

12.88

11.67

umol/l

0.32

616

(3009261) Glucose [Presence] in Urine by Test strip

658

1.43

1.23

4.9

3.9

0.00

estimate

-0.00

133

(3019309) Folate [Moles/volume] in Red Blood Cells

176

1.59

1.22

2.0

1.7

1125.28

1295.26

nmol/l

0.49

136

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

503

1.42

1.21

5.8

6.0

1.19

1.21

mmol/l

0.88

462

(3021601) Nitrite [Presence] in Urine by Test strip

641

1.41

1.19

5.0

3.9

0.00

estimate

-0.00

144

(3019150) Specific gravity of Urine by Refractometry

282

1.48

1.18

4.8

4.4

1.02

kg/l

0.72

188

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

383

1.43

1.17

3.3

3.0

2059.03

1445.73

ng/l

0.25

311

(3027801) Oxygen [Partial pressure] in Arterial blood

145

1.62

1.15

7.6

7.1

11.57

12.25

kpa

0.34

137

(42870588) Differential panel, method unspecified - Blood

394

1.42

1.14

6.1

5.8

—

(3030467) Casts [#/volume] in Urine by Automated count

331

1.43

1.11

3.2

3.0

0.36

0.52

e6/l

0.28

234

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

103

923

1.46

1.11

7.9

8.3

87.62

80.21

u/l

0.61

874

(3028707) Methadone [Presence] in Urine by Screen method

2.43

1.10

3.4

1.9

—

(3037756) Immunofixation for Serum or Plasma

2.43

1.10

1.0

1.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.25

1.10

1.0

1.3

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

122

1.65

1.09

8.5

8.0

127.21

123.61

g/l

0.33

117

(3035350) Ketones [Presence] in Urine by Test strip

647

1.39

1.09

5.0

3.9

0.00

estimate

-0.00

143

(3013650) Neutrophils [#/volume] in Blood by Automated count

691

1.38

1.03

8.7

9.9

4.49

4.16

e9/l

0.40

601

(3019977) pH of Arterial blood

142

1.56

0.99

7.9

7.4

7.41

7.42

0.29

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.92

0.99

2.8

2.1

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

220

1.46

0.99

3.9

4.0

254.36

276.93

ng/l

0.03

172

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.99

0.0

5.5

—

869.90

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

121

1128

1.59

0.98

5.2

5.0

5.86

6.01

mmol/l

0.82

109

1027

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

125

1178

1.65

0.91

5.6

5.9

2.62

2.69

mmol/l

0.32

112

1101

(4094501) Cardiovascular stress test using bicycle ergometer

2.12

0.90

1.0

1.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

252

1.41

0.88

1.4

1.8

1.03

1.33

mg/l

0.51

205

(3017732) Neutrophils [#/volume] in Blood

155

1.50

0.88

2.2

3.6

3.79

6.15

e9/l

0.84

136

(3018418) pH of Serum or Plasma

326

1.37

0.86

3.3

4.0

7.39

7.40

0.19

238

(3018095) Leukocytes [#/volume] in Urine

449

1.33

0.85

3.7

25.67

59.60

e6/l

0.69

307

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.91

0.83

1.7

1.6

—

(3009508) Creatinine [Moles/volume] in Urine

394

1.33

0.82

3.8

3.4

7.08

8.30

mmol/l

1.16

335

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.62

0.82

1.8

1.7

—

(3000492) Spirometry study

132

1.51

0.81

1.6

1.4

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

124

1.52

0.80

1.7

2.1

345.92

382.91

nmol/l

0.47

112

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.70

0.77

5.4

3.7

155.45

213.03

ng/l

0.33

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.22

0.77

1.4

1.1

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.22

0.77

1.4

1.6

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.71

0.76

1.9

2.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.72

0.74

1.4

2.7

1.42

1.38

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.59

0.71

1.4

2.7

0.62

0.61

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.96

0.71

1.6

1.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.61

0.71

1.2

1.7

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.70

0.69

2.1

2.9

—

(3012516) Albumin [Mass/volume] in Urine

375

1.30

0.68

3.8

3.5

48.69

76.62

mg/l

0.37

259

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

491

1.27

0.67

4.8

3.6

62.66

43.04

ng/l

0.20

365

(3000991) Gas panel - Venous blood

1.53

0.67

6.2

8.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.66

0.67

2.6

2.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.81

0.67

1.4

1.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.81

0.67

1.0

1.2

—

(3001604) Monocytes [#/volume] in Blood

610

1.26

0.65

6.3

6.4

0.60

0.58

e9/l

0.18

525

(3019198) Lymphocytes [#/volume] in Blood

622

1.25

0.62

6.6

1.81

e9/l

0.01

550

(1761868) Lipid panel - Serum or Plasma

505

0.78

0.62

2.8

3.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

1.69

0.62

2.4

1.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

358

0.76

0.61

2.9

3.1

0.59

0.74

ug/l

0.63

227

(3006315) Basophils [#/volume] in Blood

614

1.25

0.60

6.3

6.4

0.04

e9/l

0.14

526

(3013115) Eosinophils [#/volume] in Blood

635

1.24

0.59

6.4

6.7

0.16

0.20

e9/l

1.73

553

(3021960) Folate [Moles/volume] in Serum or Plasma

344

1.27

0.59

1.9

1.6

20.87

19.98

nmol/l

0.11

292

(4035726) Immunohistochemistry procedure

0.56

0.58

1.2

1.3

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.55

0.58

2.2

2.5

—

7.55

—

(21494755) Public health laboratory ask at order entry panel

125

0.62

0.57

1.4

1.5

—

(3020779) Urea [Moles/volume] in Serum or Plasma

1.46

0.56

4.6

7.3

10.37

8.97

mmol/l

0.16

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.65

0.56

1.2

1.4

—

(3020891) Body temperature

1.51

0.55

7.0

3.4

36.90

36.86

°c

—

(3019060) Gas panel - Arterial blood

1.51

0.52

8.0

4.1

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.52

0.52

1.0

1.2

—

(4024509) Urine culture

1.45

0.46

1.7

2.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

185

1.29

0.45

2.4

3.0

0.58

2.36

e6/l

1.48

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

883

1.20

0.42

3.4

4.0

14.56

14.89

pmol/l

0.61

808

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

0.63

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.41

0.0

1.1

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

504

1.19

0.40

5.5

3.9

0.06

0.03

estimate

0.18

123

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

114

0.68

0.39

1.4

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

303

1.21

0.38

3.4

5.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.31

0.37

10.9

7.4

15.96

16.17

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.39

0.37

12.9

6.1

25.48

24.75

mmol/l

0.30

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

156

0.75

0.37

5.3

4.8

36.29

31.78

—

103

(4034850) Laboratory test

1.48

0.36

6.8

12.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

391

1.18

0.36

4.4

4.2

11.05

14.52

mg/mmol

0.18

260

(3021589) Normoblasts [#/volume] in Blood

548

1.17

0.36

11.2

11.5

0.00

0.01

e9/l

0.54

437

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.38

0.33

1.1

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.29

0.32

1.7

1.8

—

(40761536) Microorganisms panel - Urine sediment

102

1.30

0.31

8.4

3.1

—

(40761511) CBC panel - Blood by Automated count

123

1198

1.25

0.28

20.8

14.0

—

(1002224) Polysomnography panel

1.29

0.28

1.0

1.1

—

(3005322) IgE [Units/volume] in Serum or Plasma

0.69

0.27

1.0

1.2

243.00

615.33

u/ml

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

492

1.13

0.23

2.0

1.34

1.37

mmol/l

0.11

412

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.33

0.23

4.2

2.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.33

0.23

4.2

2.1

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.23

0.22

3.6

3.5

48.60

1067.20

u/ml

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.21

0.0

1.0

—

38.40

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.1

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

1.89

—

(4062490) Immunoglobulin typing, IgG

0.00

0.21

0.0

1.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

2.5

—

89.93

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

267.60

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

478.00

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.21

0.0

1.9

—

9.08

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

0.04

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.21

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

112

0.79

0.21

1.6

1.5

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.7

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

203

1.16

0.20

2.7

0.58

0.81

e6/l

0.38

114

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.4

—

203.36

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

3.80

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

248

0.87

0.20

2.1

2.0

—

(3025941) Bacteria identified in Stool by Culture

0.73

0.17

1.4

1.3

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

0.70

0.17

2.8

2.5

3.70

1.63

mmol/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

188

1.14

0.16

1.4

1.3

24.40

37.20

iu/ml

—

(3007164) IgA [Mass/volume] in Serum or Plasma

264

0.89

0.15

1.5

3.04

2.71

g/l

0.38

165

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

118

1158

1.13

0.15

5.2

4.43

4.55

mmol/l

0.58

109

1086

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

877

0.92

0.14

4.0

3.5

81.27

52.31

u/l

0.98

827

(40768804) Tissue Pathology biopsy report

454

1.09

0.14

1.9

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

159

0.87

0.14

3.4

2.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

161

1.14

0.13

1.2

1.4

1.11

12.25

u/ml

1.51

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

188

0.89

0.12

1.2

1.6

—

(3013512) EKG study

430

1.07

0.10

5.3

3.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

124

0.88

0.09

2.0

1.7

—

(3022313) Gas panel - Capillary blood

1.14

0.09

2.0

2.7

—

(40768443) Skin Pathology biopsy report

1.14

0.09

1.3

1.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

117

1154

1.09

0.09

5.0

5.1

1.35

1.40

mmol/l

0.87

108

1078

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

1.09

0.09

1.8

1.9

225.67

225.60

pmol/l

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.81

0.08

1.4

1.1

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

0.80

0.08

2.6

2.8

4.12

4.46

pmol/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.10

0.07

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

152

0.91

0.06

1.1

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

121

0.90

0.06

2.0

1.7

—

(3026493) Urate [Moles/volume] in Serum or Plasma

337

1.05

0.05

2.0

2.7

342.20

358.94

umol/l

0.58

297

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

100

1.11

0.05

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

113

1118

1.06

0.05

4.3

1.24

1.30

mmol/l

0.46

101

1033

(3022145) Colonoscopy Study observation

130

0.92

0.05

1.5

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

209

1.06

0.05

1.4

1.5

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

241

0.95

0.04

2.3

1.8

394.89

57353371.07

pmol/l

0.50

204

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

113

1119

1.05

0.04

8.0

6.3

40.27

39.61

mmol/mol

0.32

105

1057

(3003694) ABO and Rh group [Type] in Blood

349

1.04

0.04

1.6

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

141

1.07

0.03

2.9

2.2

—

(36660697) Celiac disease serology panel - Serum

108

0.92

0.03

1.3

1.1

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

608

0.98

0.01

4.7

5.1

1.51

2.59

ug/l

1.21

552

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

287

0.97

0.01

1.3

0.59

1.34

u/ml

—

(3029937) Albumin [Presence] in Urine by Test strip

364

1.02

0.00

6.5

4.0

0.00

0.02

estimate

0.50

128

(3041096) Erythrocytes [Presence] in Urine by Automated

384

1.02

0.00

5.0

3.4

0.13

0.01

estimate

0.43

111

(3002256) Pathology report gross observation

141

0.99

0.00

1.1

1.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

483

0.99

0.00

4.1

4.5

24.11

21.46

0.46

234

(40768797) Stomach Pathology biopsy report

158

1.01

0.00

1.4

1.2

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.87

0.00

7.0

4.2

1.54

1.50

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.89

0.00

1.0

1.5

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

1211.80

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.1

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

130.33

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

4.3

—

1.00

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

-0.00

0.0

7.6

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

-0.00

0.0

5.7

—

25.37

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.2

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

-0.00

0.0

1.2

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.5

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

1.5

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.1

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

-0.00

0.0

1.4

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.8

—

(3017704) Immunofixation for Urine

0.00

-0.00

0.0

1.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

4.3

—

4.86

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.5

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3044007) Cell count panel - Peritoneal fluid

0.00

-0.00

0.0

1.6

—

(40761995) Spermatozoa Progressive [#/volume] in Semen

0.00

-0.00

0.0

3.0

—

31.60

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.1

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

2.2

—

106.33

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

1666.00

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.6

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

1.39

—

(3019083) Insulin-like growth factor [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.2

—

(3014043) Spermatozoa Nonprogressive/Spermatozoa in Semen

0.00

-0.00

0.0

6.0

—

7.00

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

60.58

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

5.0

—

157.86

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

0.00

-0.00

0.0

1.0

—

0.22

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

1.5

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.0

—

64.57

—

(3037534) Parathyrin related protein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

51.93

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.3

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

1.8

—

0.83

—

(4198724) Urine methamphetamine measurement

0.00

-0.00

0.0

2.0

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.1

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3006576) Bicarbonate [Moles/volume] in Blood

0.00

-0.00

0.0

7.6

—

26.86

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.02

-0.00

7.0

4.4

1.04

0.90

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

1.0

—

44.82

—

(3036603) Volume of Urine

0.00

-0.00

0.0

1.6

—

1613.75

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

5.8

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: ST19_CRUSHI_INJURY_ANKLE_FOOT – Crushing injury of ankle and foot

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

R14

FinnGen R13 + FinRegistry

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Crushing injury of ankle and foot

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Crushing injury of ankle and foot (ST19_CRUSHI_INJURY_ANKLE_FOOT)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints