Reiter disease

REITER

reactive arthritis: Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M02.3
  • Hospital discharge: ICD-9 0993
  • Cause of death: ICD-10 M02.3
  • Cause of death: ICD-9 0993

2 out of 7 registries used, show all original rules.

220

4. Check minimum number of events

None

220

5. Include endpoints

None

220

6. Filter based on genotype QC (FinnGen only)

214

Control definitions (FinnGen only)

Control exclude
RHEUMA_ARHTROPAT_REACTIVE

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M02
Name in latin
Morbus Reiter

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1810 445 1350
Only index persons 1625 422 1203
Unadjusted period prevalence (%)
Whole population 0.03 0.01 0.04
Only index persons 0.04 0.02 0.05
Median age at first event (years)
Whole population 43.46 44.10 43.14
Only index persons 42.52 43.47 42.19

-FinnGen-

Key figures

All Female Male
Number of individuals 214 68 146
Unadjusted period prevalence (%) 0.05 0.02 0.07
Median age at first event (years) 42.47 38.66 44.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
220
Matched controls
2200
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M02.3
ICD-10 Finland
Reiter disease
+∞
296.5
212
*
A07EC01
ATC
sulfasalazine; oral, rectal
35.0
157.4
123
77
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
23.7
129.3
126
118
L04AX03
ATC
methotrexate; systemic
14.1
78.4
91
105
L01BA01
ATC
methotrexate; systemic
27.5
76.8
56
27
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
17.5
73.7
69
56
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
391.2
60.5
58
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
12.9
53.5
59
61
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
11.5
33.0
37
38
M45
ICD-10 Finland
Ankylosing spondylitis
13.2
30.7
31
27
M13.9
ICD-10 Finland
Arthritis, unspecified
7.4
29.0
48
80
P01BA02
ATC
hydroxychloroquine; oral
7.2
27.8
47
80
H02AB06
ATC
prednisolone; systemic
4.4
24.4
148
705
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
21.3
22.5
33
18
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
8.3
20.0
28
38
L04AA13
ATC
[U] leflunomide
22.7
19.6
28
14
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
19.4
19.3
29
17
S01BA01
ATC
dexamethasone; ophthalmic
9.0
19.2
25
31
13603
ICD-8 Finland
Other and unspecified infective and parasitic diseases, Morbus Reiter, syndroma urethro-oculo-articularis
+∞
19.0
18
*
M02.8
ICD-10 Finland
Other reactive arthropathies
206.9
18.8
19
*
H02AB07
ATC
prednisone; oral
4.6
18.1
51
136
L88
ICPC
Rheumatoid/seropositive arthritis
13.2
16.6
29
25
0993A
ICD-9 Finland
Other venereal diseases, Reiter's disease
+∞
13.7
13
*
S01BA04
ATC
prednisolone; ophthalmic
20.6
13.2
19
10
L04AB01
ATC
etanercept; parenteral
24.3
13.1
18
8
ZX120
NOMESCO Finland
Intravenous
4.2
12.7
38
105
L04AB04
ATC
adalimumab; parenteral
14.5
12.2
20
15
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
21.4
11.3
16
8
S01FA02
ATC
scopolamine; ophthalmic
17.1
10.5
16
10
7111L
ICD-9 Finland
Arthropathy associated with infections, Arthropathy associated with Reiter's disease and nonspecific urethritis[UROARTHRITIS, USEAT NIVELET]
115.3
10.5
11
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
13.0
10.0
17
14
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
21.2
9.9
14
7
N48.1
ICD-10 Finland
Balanoposthitis
7.8
9.8
22
31
H20.1
ICD-10 Finland
Chronic iridocyclitis
22.9
9.5
13
6
M02.1
ICD-10 Finland
Postdysenteric arthropathy
+∞
9.4
9
*
Z3231
NOMESCO Finland
Registered nurse
2.5
9.0
76
382
J01MA02
ATC
ciprofloxacin; systemic
2.4
9.0
99
562
M01AE03
ATC
ketoprofen; systemic, rectal
2.4
8.7
96
544
M13.0
ICD-10 Finland
Polyarthritis, unspecified
21.0
8.6
12
6
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
8.5
72
361
3640A
ICD-9 Finland
Disorders of iris and ciliary body, Acute and subacute iridocyclitis
93.5
8.5
9
*
M02.0
ICD-10 Finland
Arthropathy following intestinal bypass
+∞
8.4
8
*
L40.0
ICD-10 Finland
Psoriasis vulgaris
4.9
8.3
19
42
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
8.7
8.3
17
21
L40.5
ICD-10 Finland
Arthropathic psoriasis
12.4
8.2
14
12
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.5
8.2
64
309
M01AB55
ATC
diclofenac, combinations; oral
4.3
7.8
21
53
R5110, ,
SPAT
4.8
7.8
18
40
M01CB01
ATC
sodium aurothiomalate; parenteral
26.0
7.6
10
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.2
7.5
31
106
R4110
NOMESCO Finland
Physiotherapy
2.3
7.4
72
382
71490
ICD-8 Finland
Other specified forms of arthritis, Arthritis postinfectiosa NUD
31.1
7.2
9
*
M01AH01
ATC
celecoxib; oral
2.6
7.0
47
210
L04AA01
ATC
[U] ciclosporin
17.4
6.8
10
6
M01CB03
ATC
auranofin; oral
17.4
6.8
10
6
M01AC06
ATC
meloxicam; systemic, rectal
2.1
6.6
93
568
D07XC01
ATC
betamethasone; topical
2.7
6.5
37
151
N02AX02
ATC
tramadol; systemic, rectal
2.1
6.4
109
711
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
6.4
69
379
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
11.5
6.4
11
10
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.8
6.2
33
130

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
152
885
3.32
15.54
12.1
6.3
0.61
0.60
e9/l
0.31
133
775
155
913
3.36
15.53
13.5
6.6
0.22
0.19
e9/l
1.01
139
805
152
886
3.32
15.49
12.4
6.3
0.05
0.04
e9/l
0.98
133
777
153
903
3.28
15.10
12.5
6.3
2.14
1.87
e9/l
1.44
137
807
143
816
3.15
14.89
13.6
9.6
0.00
0.00
e9/l
0.55
122
675
141
804
3.10
14.60
13.2
6.3
0.71
0.68
%
0.25
133
759
143
827
3.08
14.34
13.0
6.3
3.30
2.81
%
1.24
134
782
143
833
3.05
14.04
13.5
6.5
8.68
8.75
%
0.10
135
791
142
842
2.94
13.17
12.9
6.1
55.86
57.72
%
1.03
134
804
143
852
2.94
13.13
13.4
6.3
29.41
27.17
%
1.59
135
810
160
1021
3.08
12.79
15.7
10.3
4.32
4.11
e9/l
0.46
143
898
142
851
2.89
12.75
13.9
6.8
—
—
—
0
0
182
1279
3.45
11.71
8.7
3.9
10.51
10.83
mm/h
0.12
175
1190
84
428
2.56
9.80
9.8
6.7
—
—
—
0
0
20
24
9.05
9.80
1.9
1.3
—
—
—
0
0
39
146
3.03
8.10
5.3
5.0
0.00
0.06
%
—
8
47
180
1364
2.76
8.07
11.2
7.9
74.92
77.71
u/l
0.51
174
1287
57
264
2.56
7.91
1.3
1.3
9.95
5.58
u/ml
0.19
21
109
99
588
2.24
7.80
4.5
3.3
66.94
64.00
e6/l
0.02
73
429
53
239
2.60
7.75
1.4
1.4
320.00
516.23
titre
0.77
12
53
39
151
2.92
7.62
5.4
4.9
0.00
0.15
%
—
8
53
11
7
16.44
7.30
2.4
1.6
—
—
—
0
0
40
163
2.78
7.10
5.3
4.7
0.38
1.06
%
—
8
66
56
281
2.33
6.42
1.3
1.3
17.68
30.92
iu/ml
1.07
18
96
81
474
2.12
6.36
2.9
2.6
353.47
5422.92
umol/l
1.55
75
423
13
17
8.05
6.22
1.8
1.2
—
—
—
0
0
36
151
2.65
6.02
4.4
4.6
0.38
0.48
%
—
8
54
61
332
2.16
5.69
2.9
2.6
551.20
580.47
mosm/kgh2o
0.39
54
278
154
1168
2.06
5.65
7.0
3.8
—
—
—
0
0
22
73
3.24
5.55
1.0
1.1
—
—
—
0
0
106
712
1.94
5.49
5.0
6.2
1.21
1.21
mmol/l
0.51
98
658
61
341
2.09
5.27
1.7
1.9
—
—
—
0
0
74
455
1.94
4.86
3.7
2.7
—
—
—
0
0
82
524
1.90
4.79
3.8
2.9
72.71
159.83
e6/l
0.29
68
407
119
866
1.81
4.51
6.5
4.2
0.00
0.00
estimate
-0.00
33
174
118
860
1.80
4.42
5.1
3.1
0.00
0.01
estimate
0.50
34
181
49
270
2.05
4.34
3.6
2.7
4.24
1.57
e6/l
0.57
30
150
185
1561
2.16
4.32
25.7
16.2
14.04
14.65
%
1.57
185
1542
74
471
1.86
4.30
3.9
2.8
0.21
0.36
e6/l
0.86
59
353
118
875
1.75
4.04
5.2
3.1
0.00
0.00
estimate
-0.00
32
167
43
232
2.06
4.02
1.6
1.7
—
—
—
0
0
108
785
1.74
3.94
5.6
7.7
1.21
1.21
mmol/l
0.72
96
668
44
252
1.93
3.46
1.6
1.6
—
—
—
0
0
201
1793
2.40
3.45
21.6
13.4
21.20
23.17
mg/l
0.42
177
1413
29
145
2.15
3.29
1.3
1.6
—
—
—
0
0
71
482
1.70
3.18
4.4
4.4
7.41
7.40
ph
0.19
12
95
11
30
3.80
3.13
1.9
2.8
4.54
3.98
e9/l
0.48
11
30
55
349
1.77
3.12
2.6
2.4
3.70
3.66
e6/l
0.01
49
308
12
36
3.47
3.07
1.2
1.3
—
—
—
0
0
11
31
3.68
3.03
2.0
2.9
57.00
57.03
%
0.00
11
31
44
264
1.83
3.00
3.0
2.0
—
—
—
0
0
72
501
1.65
2.90
4.8
2.7
—
—
—
0
0
152
1271
1.63
2.83
3.6
3.8
—
—
—
0
0
68
470
1.65
2.80
5.9
3.1
0.00
0.00
estimate
-0.00
32
162
62
419
1.67
2.79
4.2
2.5
—
—
—
0
0
32
182
1.89
2.57
1.7
2.4
45.85
102.05
ug/g
2.64
23
150
66
463
1.61
2.54
5.1
4.5
—
—
—
0
0
101
784
1.53
2.49
12.9
11.9
1.17
1.19
inr
0.08
31
241
52
345
1.66
2.49
1.7
1.4
2.30
2.59
g/l
0.59
33
232
72
518
1.58
2.49
2.2
2.3
—
—
—
0
0
37
223
1.79
2.48
1.7
1.6
—
—
—
0
0
6
12
5.11
2.42
1.0
1.2
—
—
—
0
0
14
59
2.47
2.34
3.6
2.6
—
—
—
0
0
12
48
2.59
2.22
4.2
3.3
—
—
—
0
0
5
9
5.65
2.22
1.4
1.1
104.72
222.71
iu/ml
—
5
9
91
709
1.48
2.12
4.6
5.1
35.80
36.01
g/l
0.12
85
678
5
10
5.09
2.08
2.0
1.9
5.38
2.68
ug/l
—
5
10
34
211
1.72
2.07
3.2
2.7
4.76
8.19
umol/l
2.28
27
184
7
21
3.41
1.98
1.3
1.3
—
—
—
0
0
19
99
2.01
1.97
5.3
10.1
93.37
94.06
%
0.18
19
99
51
357
1.56
1.95
1.2
1.2
0.68
0.92
u/ml
0.64
12
102
96
767
1.45
1.93
2.3
2.8
—
—
—
0
0
54
389
1.51
1.81
4.5
3.1
—
—
—
0
0
5
13
3.91
1.72
1.0
1.1
—
—
—
0
0
8
31
2.64
1.67
2.9
2.9
—
—
—
0
0
8
31
2.64
1.67
2.5
2.5
—
—
—
0
0
20
114
1.83
1.63
1.3
1.3
—
42.54
—
0
7
6
20
3.05
1.59
1.2
1.1
—
—
—
0
0
5
15
3.38
1.53
1.2
1.2
—
—
—
0
0
5
15
3.38
1.53
1.0
1.0
—
—
—
0
0
66
511
1.42
1.52
2.4
2.1
1197.89
171.43
u/l
0.48
56
482
12
59
2.09
1.46
1.9
3.4
—
—
—
0
0
5
16
3.17
1.44
1.0
1.3
—
—
—
0
0
50
372
1.45
1.42
5.0
3.3
1.02
1.02
kg/l
—
5
37
16
89
1.86
1.41
3.6
7.4
23.29
24.74
mmol/l
1.08
16
89
41
294
1.48
1.40
3.1
3.7
0.81
0.82
mmol/l
0.28
36
282
189
1758
1.53
1.39
4.2
4.3
5.80
5.96
mmol/l
1.50
178
1623
51
383
1.43
1.38
1.8
1.8
0.76
1.33
mg/l
1.57
40
302
196
1839
1.60
1.37
17.9
14.9
139.76
139.71
mmol/l
0.10
196
1791
32
219
1.54
1.36
2.2
1.5
—
—
—
0
0
11
54
2.09
1.35
2.1
5.2
—
—
—
0
0
14
76
1.90
1.33
1.9
3.0
—
—
—
0
0
8
34
2.40
1.30
2.9
1.9
9.19
8.90
kpa
—
8
34
8
34
2.40
1.30
2.9
1.9
4.84
4.92
kpa
—
8
34
10
48
2.13
1.30
1.3
1.1
—
53.33
—
0
6
14
77
1.87
1.28
1.9
3.0
—
—
—
0
0
14
77
1.87
1.28
1.9
3.0
—
—
—
0
0
8
35
2.33
1.28
1.1
1.4
—
—
—
0
0
196
1847
1.56
1.25
18.0
15.0
3.95
3.99
mmol/l
1.29
196
1797
27
182
1.55
1.23
4.6
8.0
0.85
0.99
mmol/l
0.06
19
149
18
110
1.69
1.19
3.6
2.5
—
—
—
0
0
6
26
2.34
1.19
2.0
3.7
2.58
3.85
nmol/l
—
6
26
10
50
2.05
1.18
1.0
1.1
—
—
—
0
0
13
72
1.86
1.18
1.9
3.1
—
—
—
0
0
204
1945
1.67
1.17
22.4
15.4
79.59
80.37
umol/l
0.14
204
1945
121
1063
1.31
1.16
6.4
3.7
—
220.71
—
0
17
76
627
1.32
1.15
2.2
1.9
94.12
93.38
pmol/l
0.06
43
341
197
1865
1.54
1.14
5.0
4.7
2.81
2.81
mmol/l
0.01
191
1742
23
152
1.57
1.14
5.6
3.2
—
—
—
0
0
7
30
2.38
1.13
1.1
1.2
—
—
—
0
0
30
214
1.47
1.07
1.4
1.3
—
—
—
0
0
12
67
1.84
1.07
1.0
1.1
—
—
—
0
0
33
240
1.44
1.07
1.2
1.3
—
—
—
0
0
7
35
2.03
1.01
1.9
5.0
—
—
—
0
0
11
61
1.85
1.00
6.6
3.6
—
—
—
0
0
30
217
1.44
1.00
6.1
7.0
104.10
103.85
mmol/l
0.10
30
217
170
1580
1.33
1.00
4.0
4.2
1.73
1.88
mu/l
1.22
159
1433
13
77
1.73
0.97
1.9
2.5
—
—
—
0
0
20
134
1.54
0.95
4.7
8.9
—
—
—
0
0
79
670
1.28
0.95
2.0
2.0
—
—
—
0
0
38
292
1.36
0.91
3.6
3.5
318.45
277.13
ng/l
0.07
31
217
8
43
1.89
0.88
1.1
1.4
633.50
208.94
e6/l
—
8
35
46
367
1.32
0.87
2.2
1.9
2.91
3.30
mg/l
0.62
39
322
12
189
0.61
0.86
1.4
1.4
—
—
—
0
0
10
57
1.79
0.85
1.1
1.2
—
—
—
0
0
79
679
1.26
0.84
3.2
3.5
31.65
35.30
ng/l
0.13
49
453
6
33
1.84
0.79
1.0
1.2
—
—
—
0
0
0
27
0.00
0.78
0.0
1.3
—
161.41
—
0
27
62
523
1.26
0.77
2.6
3.5
8.87
8.27
mmol/l
0.34
52
450
28
211
1.37
0.77
1.6
1.4
—
—
—
0
0
9
53
1.73
0.76
1.2
1.1
—
—
—
0
0
9
55
1.66
0.74
2.0
1.7
—
—
—
0
0
53
443
1.26
0.71
1.4
1.4
—
—
—
0
0
179
1701
1.28
0.70
5.4
5.4
37.93
39.83
mmol/mol
2.91
174
1601
199
1921
1.38
0.67
16.5
12.4
—
—
—
0
0
20
146
1.41
0.66
3.3
4.2
1.01
1.85
mmol/l
0.56
12
121
54
457
1.24
0.65
1.7
1.7
1.37
1.51
mmol/l
0.74
47
382
22
164
1.38
0.65
3.0
5.0
7.15
32.60
ug/l
0.49
17
136
18
131
1.41
0.61
1.1
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
3.4
—
47.81
—
0
21
20
149
1.38
0.60
1.3
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.4
—
—
—
0
0
6
35
1.73
0.58
1.0
1.4
—
—
—
0
0
6
36
1.68
0.57
1.2
1.5
161.83
302.32
ug/g
—
6
20
44
371
1.23
0.55
2.1
1.6
28.05
20.28
nmol/l
0.37
38
323
9
60
1.52
0.55
8.1
10.7
—
—
—
0
0
9
61
1.50
0.54
2.7
1.4
—
—
—
0
0
24
188
1.31
0.54
1.3
1.3
—
—
—
0
0
18
135
1.36
0.53
4.4
3.0
—
—
—
0
0
190
1835
1.26
0.52
4.3
4.3
1.39
1.38
mmol/l
0.12
184
1713
6
40
1.51
0.52
4.8
3.0
—
—
—
0
0
78
700
1.18
0.52
3.7
2.6
251.53
162.45
ug/l
0.79
73
649
18
136
1.35
0.51
1.7
1.8
—
—
—
0
0
7
45
1.57
0.49
1.1
1.1
—
—
—
0
0
7
46
1.54
0.49
1.1
1.2
—
—
—
0
0
14
102
1.40
0.48
1.3
1.2
—
—
—
0
0
10
142
0.69
0.48
1.5
1.5
—
—
—
0
0
10
68
1.49
0.48
4.3
3.5
6.60
201.85
u/ml
—
5
55
134
1262
1.16
0.46
3.5
3.6
14.72
14.78
pmol/l
0.12
123
1145
185
1789
1.21
0.45
3.9
3.9
1.37
1.36
mmol/l
0.04
177
1661
0
15
0.00
0.41
0.0
1.3
—
1.50
—
0
15
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
5
35
1.44
0.39
1.6
1.7
—
—
—
0
0
141
1344
1.14
0.37
4.0
3.1
55.98
50.15
u/l
0.41
135
1273
7
98
0.70
0.31
3.0
3.7
126.14
129.19
g/l
—
7
98
37
327
1.16
0.30
1.7
1.7
419.66
450.79
pmol/l
0.37
29
283
7
56
1.26
0.29
5.3
2.7
83.09
157.48
mg/l
—
7
43
7
56
1.26
0.29
5.3
2.7
27.47
34.64
mg/l
—
7
43
6
83
0.72
0.24
2.0
3.4
—
—
—
0
0
12
98
1.24
0.21
1.5
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
179.67
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
8.84
—
0
13
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
13
108
1.22
0.20
4.5
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
2.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
274.14
—
0
7
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
6
52
1.16
0.19
1.0
1.2
—
—
—
0
0
6
76
0.78
0.16
2.8
2.4
0.73
0.66
%
—
6
76
9
81
1.12
0.15
3.2
2.3
—
—
—
0
0
13
150
0.86
0.15
2.1
5.0
—
—
—
0
0
206
2043
1.13
0.11
30.5
19.2
91.58
90.83
fl
1.63
206
2016
206
2043
1.13
0.11
30.4
19.2
30.45
30.39
pg
0.21
206
2016
5
46
1.09
0.09
4.4
4.1
—
—
—
0
0
10
87
1.16
0.09
3.6
9.4
—
—
—
0
0
20
184
1.10
0.09
1.4
1.5
—
—
—
0
0
27
253
1.08
0.09
1.3
1.4
—
—
—
0
0
12
134
0.89
0.09
1.5
1.4
—
—
—
0
0
50
480
1.05
0.09
3.0
3.5
211.51
192.19
mg/l
0.04
42
332
206
2046
1.11
0.08
30.7
19.3
138.53
139.74
g/l
0.54
206
2016
10
88
1.14
0.08
1.4
1.9
221.90
251.23
pmol/l
—
10
83
6
71
0.84
0.08
3.2
1.5
392.00
259.26
mu/l
—
6
65
10
111
0.90
0.06
1.1
1.1
—
—
—
0
0
16
149
1.08
0.05
6.3
8.4
9.38
9.34
mmol/l
0.01
16
144
53
517
1.03
0.04
2.8
2.7
0.52
0.71
ug/l
2.62
36
313
13
139
0.93
0.03
4.5
2.8
67.86
69.51
e9/l
—
7
103
10
92
1.09
0.03
1.2
1.2
—
—
—
0
0
51
504
1.02
0.00
3.5
4.1
26.96
9.67
mg/mmol
0.59
41
339
11
108
1.02
0.00
6.6
3.8
—
—
—
0
0
50
497
1.01
0.00
3.8
3.8
—
—
—
0
0
88
877
1.01
0.00
3.7
4.2
1.63
2.17
ug/l
0.76
79
793
0
8
0.00
0.00
0.0
1.0
—
27.50
—
0
8
7
72
0.97
0.00
1.1
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
6.6
—
—
—
0
0
8
82
0.97
-0.00
5.1
3.3
—
—
—
0
0
5
49
1.02
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
6.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.8
—
22.87
—
0
9

Mortality – FinRegistry

Association

Association between endpoint REITER and mortality.

Females

Parameter HR [95% CI] p-value
REITER 1.516 [1.12, 2.06] 0.008
Birth year 0.999 [0.99, 1.01] 0.892

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 387 females with REITER died.

Males

Parameter HR [95% CI] p-value
REITER 1.526 [1.28, 1.82] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 189 out of 1071 males with REITER died.

Mortality risk

Mortality risk for people of age

years, who have REITER.

N-year risk Females Males
1 0.168% 0.209%
5 1.11% 1.463%
10 2.728% 3.843%
15 5.054% 7.025%
20 9.186% 12.038%

Relationships between endpoints

Index endpoint: REITER – Reiter disease

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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