Reiter disease

REITER

reactive arthritis: Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M02.3
  • Hospital discharge: ICD-9 0993
  • Cause of death: ICD-10 M02.3
  • Cause of death: ICD-9 0993

2 out of 7 registries used, show all original rules.

232

4. Check minimum number of events

None

232

5. Include endpoints

None

232

6. Filter based on genotype QC (FinnGen only)

217

Control definitions (FinnGen only)

Control exclude
RHEUMA_ARHTROPAT_REACTIVE

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M02
Name in latin
Morbus Reiter

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1810 445 1350
Only index persons 1625 422 1203
Unadjusted period prevalence (%)
Whole population 0.03 0.01 0.04
Only index persons 0.04 0.02 0.05
Median age at first event (years)
Whole population 43.46 44.10 43.14
Only index persons 42.52 43.47 42.19

-FinnGen-

Key figures

All Female Male
Number of individuals 217 68 149
Unadjusted period prevalence (%) 0.05 0.02 0.07
Median age at first event (years) 42.80 38.66 44.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
223
Matched controls
2230
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M02.3
ICD-10 Finland
Reiter disease
+∞
300.8
215
*
A07EC01
ATC
sulfasalazine; oral, rectal
35.2
160.2
125
78
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
22.3
125.7
126
123
L04AX03
ATC
methotrexate; systemic
13.8
79.2
94
112
L01BA01
ATC
methotrexate; systemic
25.5
74.4
56
29
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
16.8
73.1
70
59
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
278.0
62.6
61
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
13.2
56.0
61
62
L88
ICPC
Rheumatoid/seropositive arthritis
13.7
35.1
35
30
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
10.6
31.3
37
41
M45
ICD-10 Finland
Ankylosing spondylitis
13.2
30.7
31
27
M13.9
ICD-10 Finland
Arthritis, unspecified
7.3
29.2
49
83
P01BA02
ATC
hydroxychloroquine; oral
7.2
28.3
48
82
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
19.8
22.6
34
20
H02AB06
ATC
prednisolone; systemic
4.0
22.1
149
743
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
18.7
20.3
31
19
13603
ICD-8 Finland
Other and unspecified infective and parasitic diseases, Morbus Reiter, syndroma urethro-oculo-articularis
+∞
20.1
19
*
L04AA13
ATC
[U] leflunomide
21.1
19.2
28
15
S01BA01
ATC
dexamethasone; ophthalmic
9.0
19.2
25
31
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
7.9
19.1
28
40
M02.8
ICD-10 Finland
Other reactive arthropathies
206.7
18.8
19
*
H02AB07
ATC
prednisone; oral
4.5
18.3
52
140
L04AB01
ATC
etanercept; parenteral
27.3
15.0
20
8
0993A
ICD-9 Finland
Other venereal diseases, Reiter's disease
+∞
13.7
13
*
N48.1
ICD-10 Finland
Balanoposthitis
6.9
13.6
22
35
S01BA04
ATC
prednisolone; ophthalmic
18.7
12.8
19
11
ZX120
NOMESCO Finland
Intravenous
4.1
12.7
39
110
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
15.6
12.5
20
14
L04AB04
ATC
adalimumab; parenteral
12.7
12.1
21
18
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
21.4
11.3
16
8
S01FA02
ATC
scopolamine; ophthalmic
17.1
10.5
16
10
7111L
ICD-9 Finland
Arthropathy associated with infections, Arthropathy associated with Reiter's disease and nonspecific urethritis[UROARTHRITIS, USEAT NIVELET]
115.2
10.5
11
*
M02.1
ICD-10 Finland
Postdysenteric arthropathy
+∞
10.5
10
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
24.8
10.4
14
6
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
21.2
9.9
14
7
L40.0
ICD-10 Finland
Psoriasis vulgaris
4.9
9.3
21
46
L40.5
ICD-10 Finland
Arthropathic psoriasis
13.3
9.0
15
12
M01AE03
ATC
ketoprofen; systemic, rectal
2.4
8.8
97
549
Z3231
NOMESCO Finland
Registered nurse
2.5
8.7
77
394
M13.0
ICD-10 Finland
Polyarthritis, unspecified
21.0
8.6
12
6
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
8.4
8.5
18
23
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.5
8.5
66
318
3640A
ICD-9 Finland
Disorders of iris and ciliary body, Acute and subacute iridocyclitis
93.4
8.5
9
*
M02.0
ICD-10 Finland
Arthropathy following intestinal bypass
+∞
8.4
8
*
J01MA02
ATC
ciprofloxacin; systemic
2.3
8.1
100
589
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
8.0
75
392
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.3
7.8
32
109
M01CB01
ATC
sodium aurothiomalate; parenteral
26.0
7.6
10
*
M01AB55
ATC
diclofenac, combinations; oral
4.1
7.4
21
55
L17
ICPC
Foot/toe symptom/complaint
2.3
7.2
76
415
71490
ICD-8 Finland
Other specified forms of arthritis, Arthritis postinfectiosa NUD
31.1
7.2
9
*
M01CB03
ATC
auranofin; oral
17.3
6.8
10
6
L04AA01
ATC
[U] ciclosporin
17.3
6.8
10
6
D07AD01
ATC
clobetasol; topical
2.6
6.7
44
194
D07XC01
ATC
betamethasone; topical
2.7
6.5
38
158
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
6.4
73
408
R4110
NOMESCO Finland
Physiotherapy
2.2
6.4
73
409
M01AH01
ATC
celecoxib; oral
2.4
6.3
47
220
M01AC06
ATC
meloxicam; systemic, rectal
2.0
6.2
93
577
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
10.4
6.1
11
11
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.7
6.1
35
144

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
163
1012
3.27
14.31
13.4
7.0
0.62
0.60
e9/l
0.49
144
873
166
1043
3.31
14.24
14.9
7.3
0.22
0.20
e9/l
0.71
151
912
152
910
3.11
14.17
16.4
11.9
0.00
0.00
e9/l
0.56
128
748
163
1015
3.25
14.17
13.7
7.0
0.05
0.04
e9/l
1.32
144
875
164
1025
3.27
14.16
13.7
7.1
2.14
1.90
e9/l
1.27
149
906
170
1110
3.24
13.10
17.2
11.4
4.27
4.12
e9/l
0.33
152
971
151
927
2.95
12.96
14.6
7.0
0.73
0.68
%
0.63
145
877
151
928
2.94
12.92
14.3
7.0
3.22
2.80
%
1.06
144
881
151
933
2.92
12.70
14.7
7.0
8.92
8.96
%
0.08
145
888
151
939
2.88
12.43
13.9
6.9
55.77
57.94
%
1.36
146
904
151
947
2.84
12.09
14.2
7.0
29.40
26.94
%
1.78
145
910
118
667
2.63
11.43
14.5
6.7
—
—
—
0
0
34
95
4.04
11.13
1.5
2.5
1.70
5.80
iu/ml
—
9
26
61
278
2.64
8.81
1.5
1.4
301.54
504.00
titre
0.91
13
60
47
188
2.90
8.70
6.1
5.9
0.00
0.08
%
—
9
51
98
559
2.34
8.68
9.7
6.3
—
—
—
0
0
94
534
2.31
8.33
2.9
2.8
345.76
357.32
umol/l
0.62
89
482
46
186
2.86
8.33
6.0
5.4
0.00
0.15
%
—
9
55
65
316
2.49
8.15
1.3
1.3
13.16
5.85
u/ml
0.37
24
125
47
198
2.74
7.86
6.0
5.2
0.33
1.03
%
—
9
68
26
78
3.64
7.65
1.0
1.1
—
—
—
0
0
18
28
6.90
7.59
1.7
1.2
—
—
—
0
0
113
714
2.18
7.53
5.5
3.6
87.41
61.53
e6/l
0.22
85
517
11
7
16.43
7.30
4.3
2.0
—
—
—
0
0
189
1493
2.74
7.14
12.8
8.8
76.31
79.33
u/l
0.55
184
1418
70
379
2.23
6.72
1.9
1.9
—
—
—
0
0
43
188
2.59
6.63
5.2
5.3
0.33
0.53
%
—
9
59
65
356
2.17
5.99
1.3
1.3
26.20
29.21
iu/ml
0.10
21
108
65
363
2.12
5.66
2.9
2.7
549.05
566.09
mosm/kgh2o
0.21
58
313
141
1036
1.98
5.60
5.5
3.3
0.00
0.00
estimate
-0.00
44
227
56
296
2.19
5.60
1.6
1.7
—
—
—
0
0
140
1035
1.95
5.36
5.5
3.3
0.00
0.00
estimate
-0.00
43
227
86
541
1.96
5.35
4.4
3.0
0.23
0.32
e6/l
0.51
69
397
96
630
1.92
5.25
4.4
3.1
64.68
140.00
e6/l
0.30
79
487
37
168
2.44
5.24
1.4
1.7
—
—
—
0
0
78
479
1.97
5.18
7.6
5.5
—
—
—
0
0
50
263
2.16
5.03
1.7
1.8
—
—
—
0
0
56
310
2.08
4.93
4.4
2.9
4.14
1.51
e6/l
0.58
31
158
115
819
1.83
4.73
5.8
7.1
1.21
1.21
mmol/l
0.54
110
766
16
48
3.51
4.70
1.2
1.3
—
—
—
0
0
139
1052
1.85
4.67
5.7
3.3
0.00
0.00
estimate
-0.00
42
210
190
1610
2.22
4.40
30.5
19.4
13.69
13.55
%
0.88
190
1598
70
437
1.88
4.31
2.5
2.5
3.36
3.90
e6/l
0.29
65
394
14
41
3.58
4.26
1.9
2.5
55.79
58.42
%
0.35
14
41
83
564
1.75
3.79
4.6
4.7
7.40
7.40
ph
0.90
55
403
71
461
1.79
3.79
4.4
2.6
—
—
—
0
0
121
917
1.70
3.69
6.2
8.4
1.21
1.20
mmol/l
1.00
110
799
12
30
4.17
3.65
1.8
2.8
4.35
3.98
e9/l
0.29
12
30
8
13
6.34
3.53
1.0
1.2
—
—
—
0
0
165
1387
1.73
3.19
3.9
4.1
—
20203.40
—
0
5
208
1889
2.50
3.11
25.5
15.8
23.39
24.16
mg/l
0.13
190
1565
85
608
1.64
3.10
2.2
2.5
—
—
—
0
0
77
542
1.64
2.97
5.4
4.7
—
—
—
0
0
18
77
2.46
2.90
1.4
1.3
—
—
—
0
0
81
582
1.62
2.86
5.9
3.3
0.00
0.00
estimate
-0.00
41
210
25
125
2.13
2.84
4.1
9.4
23.26
24.79
mmol/l
1.55
25
125
48
304
1.74
2.72
2.9
2.0
—
—
—
0
0
37
219
1.83
2.62
1.8
2.5
75.34
95.10
ug/g
0.34
28
182
81
598
1.56
2.49
4.8
2.8
0.00
0.01
estimate
0.80
34
186
7
16
4.48
2.49
3.9
4.3
3545.29
829.13
mg
—
7
16
25
132
2.01
2.48
5.6
11.5
93.04
93.26
%
0.06
25
132
60
421
1.58
2.28
1.8
1.5
2.67
2.58
g/l
0.09
43
279
103
815
1.49
2.24
5.3
3.2
0.00
0.00
estimate
-0.00
35
197
111
894
1.48
2.20
15.0
12.0
1.18
1.21
inr
0.24
99
749
12
49
2.53
2.14
4.2
3.6
6.86
2.60
index
—
7
30
105
842
1.47
2.10
5.2
5.3
35.85
36.10
g/l
0.17
99
810
103
823
1.47
2.10
4.3
3.2
6.19
6.12
ph
0.25
47
489
10
37
2.78
2.10
1.2
2.1
—
—
—
0
0
39
251
1.67
2.08
1.7
1.7
—
—
—
0
0
5
10
5.09
2.08
1.4
1.1
104.72
211.54
iu/ml
—
5
10
5
10
5.09
2.08
2.4
2.0
5.30
2.70
ug/l
—
5
10
29
172
1.79
2.05
5.0
10.3
—
—
—
0
0
37
240
1.65
1.92
3.1
2.9
4.79
7.62
umol/l
2.10
31
214
61
447
1.50
1.88
4.8
3.4
1.02
1.02
kg/l
0.25
37
299
9
35
2.64
1.82
3.9
2.5
—
—
—
0
0
14
67
2.16
1.80
4.4
2.5
—
—
—
0
0
6
18
3.40
1.76
1.3
1.4
—
—
—
0
0
13
61
2.20
1.75
2.2
5.1
—
—
—
0
0
38
256
1.58
1.70
2.2
1.5
—
—
—
0
0
34
224
1.61
1.67
5.0
9.0
-0.12
0.74
mmol/l
0.52
26
189
103
850
1.39
1.65
2.6
2.8
—
—
estimate
—
0
0
14
70
2.07
1.63
1.9
3.1
—
—
—
0
0
6
20
3.05
1.59
1.2
1.3
—
—
—
0
0
97
797
1.38
1.58
2.3
2.1
94.63
93.24
pmol/l
0.14
57
426
7
27
2.64
1.52
1.3
1.3
—
—
—
0
0
34
230
1.56
1.50
4.9
8.9
7.38
7.42
ph
1.19
13
129
42
299
1.50
1.48
5.7
7.4
104.79
104.05
mmol/l
0.47
42
299
16
88
1.88
1.45
1.8
2.9
—
—
—
0
0
16
88
1.88
1.45
1.8
2.8
—
—
—
0
0
5
16
3.17
1.44
1.0
1.0
—
—
—
0
0
6
22
2.77
1.44
1.0
1.2
—
—
—
0
0
16
89
1.86
1.41
1.8
2.9
—
—
—
0
0
21
129
1.69
1.35
3.8
2.9
—
—
—
0
0
15
83
1.87
1.35
1.9
3.0
—
—
—
0
0
13
228
0.54
1.33
1.6
1.5
—
—
—
0
0
15
84
1.84
1.30
1.1
1.2
—
—
—
0
0
8
34
2.40
1.30
2.9
1.9
9.19
8.90
kpa
—
8
34
8
34
2.40
1.30
2.9
1.9
4.84
4.92
kpa
—
8
34
5
18
2.82
1.29
1.2
1.3
—
—
—
0
0
8
35
2.33
1.28
2.9
3.1
—
—
—
0
0
25
164
1.59
1.27
2.8
1.8
0.00
0.08
estimate
0.49
16
36
10
49
2.09
1.24
1.2
1.2
483.60
236.57
u/ml
—
5
21
5
19
2.67
1.22
1.2
1.2
—
—
—
0
0
24
158
1.58
1.21
5.8
3.3
—
—
—
0
0
56
439
1.37
1.18
1.2
1.3
0.69
0.86
u/ml
0.47
14
124
37
270
1.44
1.17
1.2
1.3
—
—
—
0
0
56
440
1.36
1.16
1.9
1.7
0.78
1.44
mg/l
1.81
45
350
5
20
2.53
1.15
1.0
1.2
—
—
—
0
0
12
66
1.86
1.11
1.1
1.3
—
—
—
0
0
27
187
1.50
1.10
3.0
4.0
0.62
1.84
mmol/l
0.71
19
165
10
52
1.97
1.08
3.0
2.3
7.39
7.41
ph
—
10
52
15
90
1.71
1.07
1.9
2.4
—
—
—
0
0
18
114
1.63
1.06
3.6
3.4
23.11
24.25
mmol/l
0.94
18
114
72
597
1.30
1.04
2.6
2.2
1071.44
169.84
u/l
0.47
63
568
9
47
1.95
1.03
1.1
1.4
—
—
—
0
0
98
848
1.28
1.01
2.0
2.0
1.41
1.46
mmol/l
0.27
86
712
104
907
1.27
1.01
2.8
3.2
—
—
—
0
0
9
50
1.83
0.98
1.3
1.5
572.44
197.84
e6/l
—
9
37
54
435
1.32
0.95
2.2
2.0
2.61
3.10
mg/l
1.03
45
384
6
27
2.26
0.94
1.3
1.3
—
—
—
0
0
98
855
1.26
0.93
3.5
2.9
227.56
161.30
ug/l
0.70
91
806
6
28
2.17
0.92
2.7
4.1
2.50
3.64
nmol/l
—
6
28
63
521
1.29
0.92
2.1
1.7
24.50
19.41
nmol/l
0.34
54
447
33
248
1.39
0.90
1.4
1.3
—
—
—
0
0
182
1715
1.33
0.89
4.7
4.8
1.72
1.90
mu/l
1.72
174
1573
84
723
1.26
0.89
2.1
2.1
—
—
—
0
0
23
162
1.47
0.88
1.3
1.4
—
—
—
0
0
130
1177
1.25
0.88
7.1
4.0
—
180.86
—
0
21
62
517
1.28
0.85
1.4
1.4
—
—
—
0
0
6
32
1.90
0.82
1.0
1.5
—
—
—
0
0
6
32
1.90
0.82
1.0
1.5
—
—
—
0
0
6
32
1.90
0.82
1.0
1.5
—
—
—
0
0
6
32
1.90
0.82
1.0
1.5
—
—
—
0
0
0
24
0.00
0.79
0.0
3.6
—
44.67
—
0
24
0
27
0.00
0.78
0.0
1.3
—
161.41
—
0
27
18
124
1.49
0.78
1.2
1.2
—
—
—
0
0
12
75
1.63
0.76
1.6
2.8
1.64
1.45
mg/l
0.25
12
69
70
600
1.24
0.76
2.7
2.9
0.53
0.74
ug/l
3.44
43
354
7
38
1.87
0.74
1.3
1.1
—
—
—
0
0
26
195
1.38
0.73
3.0
4.0
7.37
7.39
ph
1.78
16
119
29
222
1.35
0.73
1.3
1.4
—
—
—
0
0
7
40
1.77
0.72
1.3
1.5
—
—
—
0
0
7
41
1.73
0.70
1.9
4.5
—
—
—
0
0
11
69
1.63
0.69
4.3
3.4
89.70
125.81
mg/l
0.16
11
58
11
69
1.63
0.69
4.3
3.4
29.49
32.46
mg/l
0.09
11
58
201
1940
1.37
0.66
21.9
18.0
139.80
139.73
mmol/l
0.16
201
1908
10
63
1.61
0.63
1.4
1.2
—
68.00
—
0
10
201
1944
1.34
0.61
22.0
18.2
3.97
3.99
mmol/l
0.55
201
1906
193
1857
1.29
0.61
4.8
4.9
5.82
5.98
mmol/l
1.62
185
1725
149
1397
1.20
0.61
3.9
3.9
14.74
14.78
pmol/l
0.08
141
1283
0
21
0.00
0.60
0.0
1.5
—
—
—
0
0
8
52
1.56
0.60
1.3
1.1
—
—
—
0
0
10
64
1.59
0.59
1.0
1.1
—
—
—
0
0
205
1990
1.37
0.59
17.5
13.6
—
—
—
0
0
8
54
1.50
0.58
1.1
1.2
—
—
—
0
0
24
186
1.33
0.57
3.3
5.4
6.70
29.90
ug/l
0.51
19
154
155
1464
1.19
0.56
4.3
3.4
59.77
51.77
u/l
0.56
150
1393
9
61
1.50
0.54
8.1
10.8
—
—
—
0
0
9
61
1.50
0.54
2.3
1.9
—
—
—
0
0
18
135
1.36
0.53
4.4
3.0
—
—
—
0
0
6
40
1.51
0.52
1.2
1.1
—
—
—
0
0
23
181
1.30
0.50
4.8
8.3
9.07
9.26
mmol/l
0.05
23
175
86
780
1.17
0.50
3.5
3.6
29.74
36.61
ng/l
0.29
54
537
41
350
1.21
0.47
4.2
3.7
131.29
353.74
ng/l
0.88
34
261
20
158
1.29
0.43
1.9
1.8
—
—
—
0
0
11
79
1.41
0.41
4.1
3.8
7.33
917.71
u/ml
—
6
66
29
242
1.23
0.41
1.8
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
301.13
—
0
8
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
9
67
1.36
0.38
1.3
1.2
—
—
—
0
0
208
2041
1.28
0.36
29.4
20.0
79.33
80.70
umol/l
0.31
208
2024
15
118
1.29
0.34
1.8
1.8
0.27
0.34
mg/l
—
9
58
6
46
1.31
0.33
1.2
1.4
161.83
286.43
ug/g
—
6
26
19
156
1.24
0.32
1.1
1.2
—
—
—
0
0
72
666
1.12
0.30
3.0
3.7
8.70
8.40
mmol/l
0.17
62
579
23
198
1.18
0.26
1.5
1.5
—
—
—
0
0
5
41
1.22
0.22
1.8
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
3.7
—
4.99
—
0
10
0
10
0.00
0.21
0.0
1.0
—
32.50
—
0
10
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
191.14
—
0
12
19
164
1.17
0.21
4.1
1.7
6.04
5.95
ph
0.15
13
98
0
13
0.00
0.21
0.0
1.1
—
0.31
—
0
6
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
40
367
1.11
0.20
1.8
1.8
404.62
36562947.12
pmol/l
0.50
32
320
14
118
1.20
0.19
1.6
1.9
219.21
240.11
pmol/l
0.33
14
112
6
53
1.14
0.19
1.0
1.2
—
—
—
0
0
12
100
1.21
0.18
1.5
1.8
—
—
—
0
0
6
78
0.76
0.16
1.8
3.7
25.33
25.07
mmol/l
—
6
73
60
632
0.93
0.15
3.9
4.4
19.91
9.83
mg/mmol
0.39
45
426
59
620
0.93
0.14
3.4
3.7
195.20
58.53
mg/l
0.70
46
424
5
48
1.04
0.09
4.4
4.1
—
—
—
0
0
11
98
1.13
0.08
1.2
1.2
—
—
—
0
0
6
70
0.85
0.08
2.3
2.6
26.92
24.38
mmol/l
—
6
70
101
989
1.04
0.07
4.3
4.7
1.66
2.10
ug/l
0.64
95
897
12
108
1.12
0.07
2.0
2.3
1.03
0.64
%
0.57
12
108
189
1874
1.06
0.07
4.3
4.4
1.37
1.36
mmol/l
0.09
182
1747
9
87
1.04
0.07
3.2
2.2
—
—
—
0
0
210
2088
1.10
0.06
36.6
23.4
91.85
90.99
fl
2.03
210
2069
9
100
0.90
0.06
1.2
1.1
—
0.75
—
0
14
9
103
0.87
0.06
1.2
1.1
1.33
1.48
g/l
—
9
103
210
2090
1.08
0.04
37.0
24.0
41.33
41.48
%
0.17
210
2069
210
2090
1.08
0.04
36.5
23.4
30.52
30.44
pg
0.33
210
2071
27
260
1.04
0.03
1.3
1.4
—
—
—
0
0
210
2092
1.07
0.02
36.9
23.6
137.93
139.30
g/l
0.65
210
2071
20
193
1.04
0.01
1.5
1.8
3.80
3.53
mmol/l
—
10
142
17
167
1.02
0.00
4.4
3.0
67.78
70.56
e9/l
—
9
120
194
1945
0.98
0.00
5.2
5.1
1.39
1.37
mmol/l
0.24
189
1824
10
105
0.95
0.00
1.2
1.1
0.88
0.91
g/l
—
10
105
11
115
0.95
0.00
6.7
3.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
60.80
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
57.60
—
0
5
0
5
0.00
0.00
0.0
1.2
—
12.56
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
65.47
—
0
7
7
74
0.94
-0.00
1.1
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
8.7
—
10.89
—
0
9
0
6
0.00
-0.00
0.0
2.3
—
2.33
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.9
—
18.31
—
0
9
9
93
0.97
-0.00
5.7
3.1
1.02
1.02
ratio
—
9
87
8
80
1.00
-0.00
3.0
1.7
354.87
275.33
mu/l
—
8
74
0
9
0.00
-0.00
0.0
4.3
—
46.11
—
0
9
15
150
1.00
-0.00
1.1
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
9
96
0.93
-0.00
1.7
3.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint REITER and mortality.

Females

Parameter HR [95% CI] p-value
REITER 1.516 [1.12, 2.06] 0.008
Birth year 0.999 [0.99, 1.01] 0.892

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 387 females with REITER died.

Males

Parameter HR [95% CI] p-value
REITER 1.526 [1.28, 1.82] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 189 out of 1071 males with REITER died.

Mortality risk

Mortality risk for people of age

years, who have REITER.

N-year risk Females Males
1 0.168% 0.209%
5 1.11% 1.463%
10 2.728% 3.843%
15 5.054% 7.025%
20 9.186% 12.038%

Relationships between endpoints

Index endpoint: REITER – Reiter disease

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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