Urethral discharge

R18_URETHRAL_DISCH

urethral disease: A disease involving the urethra. [database_cross_reference: MONDO:DesignPattern]

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — R36 Cause of death: ICD-10 — R36 2 out of 7 registries used, show all original rules.	44
4. Check minimum number of events None	44
5. Include endpoints None	44
6. Filter based on genotype QC (FinnGen only)	44

Control definitions (FinnGen only)

Control exclude: R18_SYMPTOMS_SIGNS_INVOLVI_URINARY_SYSTEM

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: R3
Name in latin: Fluor urethralis

NAME	R18_URETHRAL_DISCH
CONTROL_EXCLUDE	R18_SYMPTOMS_SIGNS_INVOLVI_URINARY_SYSTEM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	R36
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	R36
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Urethral discharge based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	44	17	27
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	49.52	44.85	52.45

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

4.50

3.58

6.4

2.5

26.10

25.82

u/l

—

(3026008) Bacteria identified in Urine by Culture

3.44

3.57

3.6

2.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

229

3.58

3.39

7.1

3.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

109

3.04

3.19

5.9

2.3

—

(3049717) Cytology report of Urine Cyto stain

8.45

3.16

1.2

3.1

—

(3002030) Lymphocytes/100 leukocytes in Blood

151

3.04

3.15

6.4

5.4

31.37

26.84

1.61

144

(36304419) Bacteria [Presence] in Urine

2.87

2.81

5.9

1.9

—

(3003694) ABO and Rh group [Type] in Blood

2.87

2.81

1.7

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

3.13

2.65

5.1

1.7

0.71

0.68

e6/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

3.33

2.60

4.2

2.0

—

(3000850) Epithelial cells [#/volume] in Urine

2.88

2.53

3.9

1.9

2.01

4.13

e6/l

1.03

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

3.14

2.52

5.4

1.8

0.40

3.00

e6/l

—

(3000991) Gas panel - Venous blood

4.01

2.40

6.4

3.9

—

(3019069) Monocytes/100 leukocytes in Blood

150

2.54

2.33

6.7

5.6

8.29

8.64

0.26

145

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

3.20

2.28

3.8

1.8

—

(42870588) Differential panel, method unspecified - Blood

109

2.53

2.26

6.3

5.2

—

(3022096) Basophils/100 leukocytes in Blood

143

2.49

2.25

6.9

5.3

0.53

0.67

0.76

135

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

4.78

2.23

4.0

3.0

0.90

1.84

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

171

2.50

2.20

8.0

6.2

10.09

10.42

umol/l

0.12

164

(40758558) Short blood count panel - Blood

2.69

2.16

7.5

6.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

4.45

2.12

5.7

2.5

—

(3002256) Pathology report gross observation

3.16

2.07

1.3

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.61

1.95

4.3

2.8

—

(3023368) Bacteria identified in Blood by Culture

2.48

1.93

8.4

4.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

2.51

1.90

2.0

1.8

1.28

1.61

mg/l

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

4.55

1.87

1.0

1.1

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

4.55

1.87

1.8

—

216.80

—

(3034770) Mitochondria Ab [Titer] in Serum

4.55

1.87

1.2

1.4

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

118

2.27

1.83

6.8

2.5

33.65

34.48

u/l

0.05

107

(3028300) Cannabinoids [Presence] in Urine

4.19

1.76

1.0

1.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

4.19

1.76

3.4

4.8

26.72

23.84

mmol/l

—

(3016879) Cocaine [Presence] in Urine

4.19

1.76

1.0

1.1

—

(3027008) Opiates [Presence] in Urine

4.19

1.76

1.0

1.2

—

(3000764) Benzodiazepines [Presence] in Urine

4.19

1.76

1.0

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

155

2.21

1.75

8.8

4.3

0.00

estimate

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.60

1.74

2.6

1.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.13

1.73

3.1

1.8

—

(40761536) Microorganisms panel - Urine sediment

3.13

1.73

6.7

3.1

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

203

2.26

1.72

5.1

3.7

6.78

6.59

mmol/l

0.19

181

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.33

1.71

2.5

1.9

—

(3029937) Albumin [Presence] in Urine by Test strip

2.33

1.71

6.9

2.9

0.00

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

157

2.16

1.67

6.5

2.8

0.00

estimate

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

3.00

1.66

9.4

3.0

6.17

5.63

kpa

—

(3002032) Base excess in Venous blood by calculation

3.00

1.66

9.4

3.0

1.17

3.13

mmol/l

—

(3012544) pH of Venous blood

3.00

1.66

9.4

3.0

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.62

1.57

5.4

3.3

151.40

131.20

g/l

—

(3018010) Neutrophils/100 leukocytes in Blood

151

2.10

1.56

7.1

5.0

52.28

58.99

2.26

146

(3009261) Glucose [Presence] in Urine by Test strip

162

2.06

1.49

6.6

3.0

0.00

estimate

—

(3015736) pH of Urine

118

2.07

1.47

6.9

2.6

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.85

1.42

4.8

3.1

5.90

4.88

kpa

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.31

1.37

1.7

1.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.56

1.35

1.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

3.00

1.32

1.4

1.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.58

1.18

6.0

3.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.11

1.15

1.5

1.4

—

(3018418) pH of Serum or Plasma

1.95

1.11

6.6

2.7

7.41

7.40

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

245

1.90

1.08

3.4

3.2

—

(3002385) Erythrocyte distribution width [Ratio]

301

2.08

1.07

29.6

13.9

13.47

13.51

0.07

293

(3000492) Spirometry study

2.18

1.05

1.0

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

121

1.83

1.05

6.2

3.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

130

1.81

1.05

5.4

3.6

19.56

64.26

ng/l

0.81

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

2.02

0.97

1.7

2.3

1.39

1.35

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

143

1.73

0.93

6.6

4.8

1.20

1.21

mmol/l

0.13

118

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.95

0.90

2.6

2.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

157

1.65

0.80

4.9

3.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.72

0.79

7.2

2.8

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

268

1.71

0.77

12.3

6.8

76.06

77.28

u/l

0.07

256

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

2.22

0.77

2.2

2.3

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

2.12

0.75

3.4

3.3

1.20

1.22

mmol/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.84

0.74

1.4

1.3

—

(3012516) Albumin [Mass/volume] in Urine

1.67

0.73

3.1

2.9

42.02

40.66

mg/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.70

0.69

1.6

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

108

1.59

0.64

3.1

2.4

—

(3042936) Bacteria identified in Isolate by Culture

1.66

0.64

1.5

2.0

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.77

0.59

5.8

2.2

5.33

8.26

umol/l

—

(3044889) 12 lead EKG panel

246

1.52

0.58

4.1

3.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.51

0.56

2.4

1.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

1.55

0.49

1.1

1.3

0.68

1.17

u/ml

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.48

0.41

3.2

1.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

371

0.72

0.40

5.3

3.8

1.43

1.33

mmol/l

0.25

346

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

363

1.65

0.40

26.0

11.5

20.66

20.03

mg/l

0.04

271

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

138

1.38

0.38

3.9

4.5

27.02

23.82

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

139

1.36

0.36

2.2

1.7

98.29

94.08

pmol/l

—

(3013512) EKG study

111

1.38

0.36

4.9

3.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

103

1.37

0.33

4.8

3.7

6.43

3.99

mg/mmol

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.39

0.29

2.2

4.5

—

(3022145) Colonoscopy Study observation

1.40

0.24

1.8

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.32

0.24

6.6

6.5

—

(3000494) Fungus identified in Specimen by Culture

1.25

0.23

1.0

1.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.9

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(4034850)

0.00

0.21

0.0

2.9

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

3.5

—

10.15

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3037522) Nuclear Ab [Titer] in Serum

1.29

0.21

1.2

1.5

—

410.91

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

2.6

—

(3019150) Specific gravity of Urine by Refractometry

1.20

0.19

9.0

2.6

—

1.02

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.20

0.19

1.3

1.2

—

32.58

—

(1761868) Lipid panel - Serum or Plasma

164

1.17

0.12

3.9

2.8

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.15

0.10

7.2

1.4

2.06

2.64

g/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

380

1.23

0.09

5.6

4.1

1.32

1.43

mmol/l

1.47

357

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

0.83

0.08

3.4

2.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

341

1.13

0.07

28.0

11.6

42.37

41.21

0.81

267

(40768804) Tissue Pathology biopsy report

130

1.11

0.05

2.2

2.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.3

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

3.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

2.4

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

1.2

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.3

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.8

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

12.24

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.3

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.2

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

217.20

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(1175426) CD3 cells/100 lymphocytes in Blood

0.00

0.0

3.2

—

71.40

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.1

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

1.28

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

0.26

—

(3001405) CD3+CD8+ (T8 suppressor) cells [#/volume] in Blood

0.00

0.0

3.2

—

303.40

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.2

—

4.36

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.2

—

(4062490)

0.00

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.6

—

1.44

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.0

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.7

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

1.81

—

(3025577) Chromium [Mass/volume] in Blood

0.00

0.0

2.2

—

2.66

—

(40768797) Stomach Pathology biopsy report

1.00

0.00

1.0

1.2

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

1.10

—

(3010503) CD19 cells [#/volume] in Blood

0.00

0.0

2.0

—

0.14

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.98

0.00

1.6

2.1

—

(3025271) CD3-CD16+CD56+ (Natural killer) cells [#/volume] in Blood

0.00

0.0

3.0

—

0.11

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.8

—

13.60

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: R18_URETHRAL_DISCH – Urethral discharge

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Urethral discharge

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Urethral discharge (R18_URETHRAL_DISCH)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints