No definition available.
Renal agenesis and other reduction defects of kidney
Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
190 |
4. Check minimum number of eventsNone |
190 |
5. Include endpointsNone |
190 |
6. Filter based on genotype QC (FinnGen only) |
165 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_URINARY_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q6[0-4]
- Name in latin
- Agenesis/aplasia/hypoplasia/atrophia renis/renum
Similar endpoints
↥List of similar endpoints to
Renal agenesis and other reduction defects of kidney
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the urinary system
- Congenital malformations of the urinary system, including avohilmo
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly, including avohilmo
- All chronic kidney diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1672 | 714 | 949 |
| Only index persons | 1260 | 565 | 695 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 14.59 | 17.97 | 11.61 |
| Only index persons | 24.56 | 26.79 | 22.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 165 | 71 | 94 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 44.75 | 36.89 | 50.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 179
- Matched controls
- 1790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q60.0
ICD-10 Finland
Renal agenesis, unilateral
+∞
115.5
98
*
A11CC03
ATC
alfacalcidol; systemic
85.7
114.0
62
11
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
35.3
104.6
74
35
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
72.9
93.5
52
10
N18.8
ICD-10 Finland
Other chronic renal failure
45.2
75.9
47
14
L04AA06
ATC
mycophenolic acid; systemic
48.3
72.6
44
12
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
120.4
65.7
68
9
Q60.3
ICD-10 Finland
Renal hypoplasia, unilateral
+∞
53.9
49
*
Z94.0
ICD-10 Finland
Kidney transplant status
235.7
52.0
51
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
15.4
50.5
50
44
A12AA04
ATC
calcium carbonate; oral
90.7
48.3
52
8
127
Kela drug reimbursment
Transplant complication
100.9
48.0
51
7
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
159.6
37.3
38
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
437.5
36.3
35
*
205
Kela drug reimbursment
Chronic hypertension
6.6
34.7
83
207
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
112.0
34.2
36
*
137
Kela drug reimbursment
Uraemia requiring dialysis
112.0
34.2
36
*
H02AB04
ATC
methylprednisolone; systemic
7.2
32.5
62
123
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.9
31.8
46
67
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
96.4
29.9
32
*
TK800
NOMESCO Finland
Hemodialysis
40.5
29.1
36
11
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.1
29.0
68
163
N18.0
ICD-10 Finland
End-stage renal disease
330.3
28.6
28
*
N19
ICD-10 Finland
Unspecified kidney failure
12.6
27.6
29
27
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
85.8
26.7
29
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
40.0
26.7
33
10
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
151.1
25.3
26
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
57.2
25.1
29
6
B03XA02
ATC
darbepoetin alfa; parenteral
44.6
24.8
30
8
L04AD02
ATC
tacrolimus; systemic
78.9
24.6
27
*
B05DA
ATC
Isotonic solutions
96.4
23.3
25
*
L04AD01
ATC
ciclosporin; systemic
26.5
22.6
31
14
C08CA02
ATC
felodipine; oral
8.0
22.6
34
51
Q60.2
ICD-10 Finland
Renal agenesis, unspecified
+∞
22.4
21
*
Q60.4
ICD-10 Finland
Renal hypoplasia, bilateral
+∞
22.4
21
*
C03CA01
ATC
furosemide; systemic
4.5
21.9
80
270
M04AA01
ATC
allopurinol; systemic
5.5
21.3
50
117
Z49.0
ICD-10 Finland
Preparatory care for dialysis
65.5
20.4
23
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.2
20.1
29
41
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.4
20.0
32
51
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
78.7
19.2
21
*
ZXE20
NOMESCO Finland
More than three and less than five hours
5.1
18.9
49
124
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
16.9
18.9
30
21
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
211.2
18.9
19
*
B05DB
ATC
Hypertonic solutions
59.1
18.4
21
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
7.3
18.2
29
46
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
5.0
18.0
46
115
196
Kela drug reimbursment
Paricalcitol and cinacalcet
198.9
17.9
18
*
L04AA01
ATC
[U] ciclosporin
55.9
17.4
20
*
Z49.2
ICD-10 Finland
Other dialysis
55.9
17.4
20
*
N26
ICD-10 Finland
Unspecified contracted kidney
+∞
16.9
16
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
186.7
16.8
17
*
C08CA01
ATC
amlodipine; oral
3.7
16.3
86
361
C07AB02
ATC
metoprolol; systemic
4.4
16.1
49
140
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
+∞
15.9
15
*
H05BX01
ATC
cinacalcet; oral
162.7
14.7
15
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
46.7
14.4
17
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
46.7
14.4
17
*
UKC02
NOMESCO Finland
Cystoscopy
4.3
14.1
44
127
TK820
NOMESCO Finland
Peritoneal dialysis
58.2
14.1
16
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
58.2
14.1
16
*
V03AE02
ATC
sevelamer; oral
81.1
13.8
15
*
R50.9
ICD-10 Finland
Fever, unspecified
3.6
13.2
57
206
C09AA02
ATC
enalapril; systemic
3.8
13.2
49
160
B03XA01
ATC
erythropoietin; parenteral
34.9
12.8
16
5
Q60.5
ICD-10 Finland
Renal hypoplasia, unspecified
+∞
12.6
12
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.1
12.4
85
404
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
69.6
11.8
13
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.1
11.5
21
38
Z2446
NOMESCO Finland
Social worker
4.2
11.3
34
95
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.5
11.1
47
166
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.5
11.1
30
77
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.0
11.0
36
107
C08CA05
ATC
nifedipine; systemic
6.1
11.0
20
36
V03AE01
ATC
polystyrene sulfonate; oral
30.2
10.9
14
5
7530A
ICD-9 Finland
Congenital anomalies of urinary system, Renal agenesis and dysgenesis[AGENESIA RENIS]
+∞
10.5
10
*
75301
ICD-8 Finland
Congenital anomalies of urinary system, Agenesis renis unilateralis
+∞
10.5
10
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
10.4
69
317
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.2
10.1
29
78
M10.9
ICD-10 Finland
Gout, unspecified
4.7
10.0
25
60
U14
ICPC
Kidney symptom/complaint
16.2
9.7
15
10
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
31.9
9.5
12
*
V03AE03
ATC
lanthanum carbonate; oral
105.4
9.5
10
*
KC1JB
NOMESCO Finland
Miktiocystography with X-ray
+∞
9.5
9
*
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
+∞
9.5
9
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
12.4
9.3
16
14
RD210, ,
NOMESCO Finland
7.5
9.2
21
31
K06.18
ICD-10 Finland
Another gingival hyperplasia
38.8
9.1
11
*
N18
ICD-10 Finland
Chronic kidney disease
38.8
9.1
11
*
3AC01, ,
NOMESCO Finland
38.8
9.1
11
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
8.7
9.1
19
24
A02BC01
ATC
omeprazole; systemic
2.9
9.0
56
246
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.7
9.0
65
309
XPX08
NOMESCO Finland
Intraoperative flow measurement
52.6
8.8
10
*
204
Kela drug reimbursment
Leukemia lymphatica
12.5
8.7
15
13
L04AX01
ATC
azathioprine; systemic
7.4
8.6
20
30
C07AG02
ATC
carvedilol; oral
5.3
8.6
18
37
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
94.3
8.5
9
*
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
94.3
8.5
9
*
KBV00
NOMESCO Finland
Insertion of stent into ureter
94.3
8.5
9
*
Q61.48
ICD-10 Finland
Nonspecified renal dysplasia
+∞
8.4
8
*
Q62.7
ICD-10 Finland
Congenital vesico-uretero-renal reflux
+∞
8.4
8
*
A12AA12
ATC
[U] calcium acetate
+∞
8.4
8
*
Z3231
NOMESCO Finland
Registered nurse
2.6
8.3
71
364
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.2
8.2
37
135
C08CA13
ATC
lercanidipine; oral
3.4
8.1
32
107
Z3229
NOMESCO Finland
Other healthcare associate professional
3.7
8.0
27
81
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.5
7.7
15
17
C09CA01
ATC
losartan; oral
2.7
7.7
51
230
JN3AD
NOMESCO Finland
Abdominal CT examination
3.3
7.5
32
112
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
14.2
7.5
12
9
TPX10
NOMESCO Finland
Implantation of vascular injection port
7.4
7.5
17
25
XKD00
NOMESCO Finland
Uroflowmetry
3.0
7.5
39
154
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
7.5
79
443
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.8
7.3
17
38
KAS20
NOMESCO Finland
Allogenic transplantation of kidney from living donor
+∞
7.3
7
*
Q60.1
ICD-10 Finland
Renal agenesis, bilateral
+∞
7.3
7
*
RJ421, ,
NOMESCO Finland
+∞
7.3
7
*
N25.0
ICD-10 Finland
Renal osteodystrophy
+∞
7.3
7
*
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
+∞
7.3
7
*
Q62.0
ICD-10 Finland
Congenital hydronephrosis
+∞
7.3
7
*
Q61.40
ICD-10 Finland
Renal dysplasia of a kidney (multicystic)
+∞
7.3
7
*
XF602
NOMESCO Finland
Bloodpressure monitoring
16.6
7.3
11
7
Z3226
NOMESCO Finland
Physiotherapist
2.7
7.3
49
221
J01EA01
ATC
trimethoprim; systemic
2.7
7.3
47
208
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
31.4
7.2
9
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
7.0
49
226
R4110
NOMESCO Finland
Physiotherapy
2.4
6.9
64
336
Z99.2
ICD-10 Finland
Dependence on renal dialysis
41.7
6.8
8
*
KAC00
NOMESCO Finland
Nephrectomy
41.7
6.8
8
*
E87.5
ICD-10 Finland
Hyperkalaemia
12.9
6.7
11
9
A02BA02
ATC
ranitidine; systemic
2.9
6.6
35
139
KH1EE
NOMESCO Finland
Urologic ultrasound examination
72.3
6.5
7
*
5AB14, ,
NOMESCO Finland
72.3
6.5
7
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
6.4
49
235
H05BX02
ATC
paricalcitol; systemic
+∞
6.3
6
*
7910X
ICD-9 Finland
Nonspecific findings on examination of urine, Proteinuria[PROTEINURIA NUD]
+∞
6.3
6
*
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
+∞
6.3
6
*
RJ190, ,
NOMESCO Finland
+∞
6.3
6
*
5850B
ICD-9 Finland
Chronic renal failure[INSUFFICIENTIA RENIS CHRONICA CUM URAEMIA]
+∞
6.3
6
*
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
+∞
6.3
6
*
TJW99
NOMESCO Finland
Other minor procedure in gastrointestinal endoscopy
+∞
6.3
6
*
7151
FHL
Kidney transplantation
+∞
6.3
6
*
75302
ICD-8 Finland
Congenital anomalies of urinary system, Hypoplasia et dysplasia renis
+∞
6.3
6
*
Q60
ICD-10 Finland
Renal agenesis and other reduction defects of kidney
+∞
6.3
6
*
RJ410, ,
NOMESCO Finland
+∞
6.3
6
*
J01MA02
ATC
ciprofloxacin; systemic
2.2
6.2
71
406
212
Kela drug reimbursment
Gout
9.1
6.2
12
14
K65.0
ICD-10 Finland
Acute peritonitis
13.1
6.2
10
8
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
10.6
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
80
115
11.77
58.38
11.3
4.2
134.61
67.28
ng/l
4.73
75
104
37
36
12.70
34.53
9.8
7.3
832.13
703.83
iu/ml
—
8
6
104
361
5.49
28.89
10.3
2.7
4.29
4.74
e6/l
0.14
97
326
125
559
5.10
23.97
12.3
3.4
—
—
—
0
0
104
424
4.47
22.04
11.4
4.0
32.93
12.08
mg/mmol
1.76
83
281
32
46
8.25
21.99
2.0
1.5
160.67
104.50
au/ml
—
9
18
113
490
4.54
21.99
9.4
3.5
6.56
8.05
mmol/l
3.68
106
427
115
523
4.35
20.53
11.6
3.4
98.81
37.53
e6/l
0.47
105
405
32
50
7.58
20.41
2.0
1.4
—
—
—
0
0
57
163
4.66
18.97
11.3
10.2
22.81
23.64
mmol/l
1.62
57
163
63
210
4.09
16.90
12.9
8.9
-0.00
1.02
mmol/l
1.51
56
170
99
452
3.66
16.55
11.3
3.2
0.20
0.22
e6/l
0.08
89
341
43
109
4.88
16.44
4.3
2.1
45.11
66.55
ml/min/173m2
2.40
18
42
127
691
3.88
15.96
26.2
10.1
1.24
1.22
mmol/l
1.80
121
653
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
36
7.54
15.73
3.2
4.9
0.25
0.31
iu/ml
—
10
24
133
759
3.93
15.25
26.6
10.5
1.22
1.21
mmol/l
0.62
123
673
29
55
6.10
15.24
1.6
1.5
211.00
166.94
u/ml
0.43
21
24
121
651
3.65
15.19
12.9
6.6
35.56
36.10
g/l
0.48
115
619
29
57
5.88
14.67
1.6
1.5
—
—
—
0
0
39
102
4.61
14.24
16.1
4.6
1.21
1.23
mmol/l
0.55
34
87
122
681
3.49
13.99
5.0
2.6
73.37
73.04
nmol/l
0.05
117
622
68
275
3.37
13.22
5.2
3.0
0.41
0.83
e6/l
1.30
48
157
25
27
10.57
12.99
16.3
3.4
15.63
8.25
pmol/l
1.38
25
27
63
258
3.22
11.81
5.3
3.2
1.65
1.99
e6/l
0.14
42
141
133
842
3.26
11.22
9.9
3.7
0.00
8.78
estimate
0.50
39
185
132
834
3.22
11.13
9.7
3.6
0.00
0.00
estimate
-0.00
39
183
133
850
3.20
10.87
9.9
3.7
0.00
0.00
estimate
-0.00
36
174
24
54
4.98
10.37
6.4
12.6
21.34
23.79
mmol/l
2.43
24
54
21
33
7.06
8.80
10.6
3.2
4.78
5.01
kpa
0.82
21
33
33
110
3.45
8.41
2.5
4.3
64.80
66.32
g/l
0.63
33
105
40
152
3.10
8.24
5.8
3.3
—
—
—
0
0
18
39
5.02
8.07
2.9
1.6
—
—
—
0
0
29
93
3.53
7.82
9.3
10.3
0.66
0.60
%
0.53
29
93
42
172
2.88
7.55
2.8
2.0
—
—
—
0
0
44
185
2.83
7.53
9.6
15.3
22.97
24.82
mmol/l
3.91
44
185
47
205
2.75
7.51
9.3
11.0
103.87
104.11
mmol/l
0.13
47
205
17
38
4.84
7.35
5.1
2.3
124.41
132.61
g/l
0.59
17
28
19
35
5.94
7.15
1.5
4.5
96.23
228.99
mg/l
0.34
13
29
19
35
5.94
7.15
1.5
4.5
50.37
30.30
mg/l
0.99
12
29
136
980
2.61
7.14
11.1
4.1
2260.14
94.06
e6/l
—
7
16
42
177
2.79
7.14
2.7
1.9
—
—
—
0
0
18
32
6.13
6.97
1.4
4.1
1.58
3.12
ratio
—
9
16
85
511
2.26
6.64
7.9
3.5
2.39
2.36
mmol/l
1.42
80
467
17
42
4.37
6.52
4.0
3.1
1.50
1.70
index
—
8
27
39
166
2.73
6.47
7.9
9.6
0.39
1.20
mmol/l
0.85
23
120
78
458
2.25
6.39
12.0
3.7
0.00
0.00
estimate
-0.00
33
168
112
770
2.21
6.10
8.0
3.1
180.55
101.85
ug/l
3.69
106
734
50
251
2.38
5.85
2.7
2.0
—
—
—
0
0
17
47
3.89
5.63
1.9
1.5
—
—
—
0
0
41
191
2.49
5.63
2.6
5.0
220.20
282.03
u/l
1.51
41
185
14
27
5.53
5.20
1.6
2.2
1.56
1.54
mmol/l
0.03
14
27
69
413
2.09
5.17
3.1
2.7
2.73
2.76
mg/l
0.05
61
367
18
57
3.40
4.91
2.8
1.2
—
—
—
0
0
94
638
2.00
4.91
10.3
3.5
0.00
0.01
estimate
0.50
33
154
17
52
3.51
4.89
1.4
1.9
—
—
—
0
0
75
473
2.01
4.80
4.0
3.0
66.88
66.13
u/l
0.03
75
435
15
36
4.45
4.64
1.1
1.2
—
—
—
0
0
17
54
3.37
4.62
1.4
2.0
—
—
—
0
0
75
481
1.96
4.52
9.2
3.2
0.00
0.00
estimate
-0.00
32
146
10
16
6.55
4.36
1.3
1.6
—
—
—
0
0
9
13
7.22
4.21
5.8
4.4
1267.56
589.85
mg
—
9
13
12
26
4.87
4.14
1.2
1.5
—
—
—
0
0
7
7
10.34
4.04
1.0
1.1
1258.29
1639.86
miu/ml
—
7
7
13
33
4.16
3.88
1.2
1.8
—
—
—
0
0
57
353
1.90
3.69
3.1
2.9
—
—
—
0
0
23
102
2.44
3.46
2.9
1.7
—
—
—
0
0
12
32
3.94
3.46
1.3
1.5
—
—
—
0
0
12
32
3.94
3.46
1.4
1.6
—
—
—
0
0
12
32
3.94
3.46
1.3
1.5
—
—
—
0
0
30
151
2.19
3.40
5.2
12.4
0.29
0.82
mmol/l
0.18
24
129
91
673
1.72
3.15
4.5
3.3
—
—
estimate
—
0
0
10
25
4.17
3.13
1.5
2.1
—
—
—
0
0
13
45
3.04
3.09
1.5
1.8
—
—
—
0
0
7
12
6.02
3.05
1.0
1.5
—
—
—
0
0
38
218
1.94
3.04
1.9
1.6
1389.74
1239.94
nmol/l
0.45
31
168
11
32
3.59
2.95
1.5
1.9
—
—
—
0
0
10
27
3.86
2.93
1.2
1.5
—
—
—
0
0
115
918
1.71
2.91
11.6
6.9
6.53
6.50
mmol/l
0.06
110
871
18
81
2.36
2.64
3.0
11.3
22.80
24.06
mmol/l
0.70
18
81
120
985
1.66
2.58
11.2
11.5
4.25
3.99
e9/l
0.74
105
866
54
368
1.67
2.42
8.8
3.6
1.02
1.02
kg/l
0.99
46
248
7
17
4.24
2.38
1.0
1.1
—
—
—
0
0
79
601
1.56
2.23
2.5
1.9
100.72
93.59
pmol/l
0.78
44
332
149
1322
1.76
2.11
6.3
4.1
1.48
1.27
mmol/l
2.26
142
1240
8
26
3.17
2.04
1.5
1.2
—
—
—
0
0
12
53
2.35
1.85
2.0
3.0
—
—
—
0
0
52
389
1.47
1.50
3.3
3.5
8027.33
1179.25
ng/l
2.35
47
318
6
24
2.55
1.31
1.2
1.2
—
—
—
0
0
6
24
2.55
1.31
1.3
1.3
—
2.18
—
0
11
10
48
2.15
1.30
1.5
1.2
—
—
—
0
0
5
18
2.83
1.29
1.8
1.2
496.40
707.06
pmol/l
—
5
18
66
529
1.39
1.29
3.9
3.8
44.34
35.88
ng/l
0.34
53
354
6
25
2.45
1.25
1.3
1.2
—
2.73
—
0
11
10
50
2.06
1.19
1.5
1.2
—
—
—
0
0
0
35
0.00
1.16
0.0
1.1
—
70.50
—
0
6
164
1551
1.68
1.12
37.8
15.7
21.65
23.04
mg/l
0.24
143
1249
150
1392
1.48
1.12
7.4
4.7
1.41
1.42
mmol/l
0.13
143
1308
14
82
1.77
1.08
2.1
2.3
210.36
6755.50
u/l
—
5
28
150
1395
1.46
1.07
7.5
4.8
4.34
4.56
mmol/l
2.06
144
1314
7
33
2.17
1.07
1.4
1.6
—
—
—
0
0
144
1332
1.41
1.04
39.2
14.1
59.77
86.62
ml/min/173m2
16.57
138
1203
127
1376
0.73
1.04
7.5
4.6
5.73
5.88
mmol/l
0.88
117
1265
7
35
2.04
1.01
1.0
1.2
—
—
—
0
0
9
52
1.77
0.94
2.1
2.3
178.56
221.93
pmol/l
—
9
46
151
1417
1.42
0.92
7.7
5.3
2.42
2.69
mmol/l
3.84
143
1332
36
277
1.38
0.88
2.6
2.8
2.48
2.44
mmol/l
1.32
28
244
8
45
1.81
0.85
2.0
2.4
—
—
—
0
0
6
33
1.85
0.80
2.2
1.5
—
—
—
0
0
6
33
1.85
0.80
1.5
1.5
—
—
—
0
0
6
34
1.79
0.77
1.0
1.0
1.41
1.40
g/l
—
6
29
5
24
2.11
0.75
1.4
1.6
—
—
—
0
0
7
41
1.74
0.71
1.6
1.3
—
—
—
0
0
20
268
0.71
0.68
2.0
2.4
—
—
—
0
0
7
43
1.65
0.67
1.3
1.5
—
—
—
0
0
12
80
1.54
0.61
1.5
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
12.44
—
0
7
42
351
1.26
0.59
1.8
2.6
1.30
1.38
mg/l
0.09
33
283
9
62
1.48
0.54
2.2
1.8
41.89
41.73
u/l
—
9
57
12
84
1.46
0.50
4.9
1.7
—
—
—
0
0
66
591
1.18
0.47
2.6
2.0
1.44
1.34
mmol/l
0.39
60
512
138
1319
1.20
0.44
10.2
5.9
38.97
38.81
mmol/mol
0.08
131
1253
10
70
1.45
0.42
2.3
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
227.87
—
0
15
0
18
0.00
0.40
0.0
1.5
—
32.57
—
0
12
14
180
0.76
0.39
3.6
2.7
13.36
13.06
nmol/l
0.05
14
165
20
245
0.79
0.39
1.9
2.3
—
—
—
0
0
10
72
1.41
0.37
1.4
1.5
115.30
267.55
miu/ml
—
5
37
12
91
1.34
0.34
1.4
1.3
—
—
—
0
0
8
62
1.30
0.28
1.5
1.6
—
—
—
0
0
10
127
0.77
0.26
1.2
1.8
2.98
3.51
mmol/l
—
5
93
18
152
1.20
0.25
1.7
2.5
—
—
—
0
0
110
1143
0.90
0.24
4.0
3.5
—
—
—
0
0
10
125
0.79
0.23
1.1
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
0.17
—
0
10
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
10.80
—
0
10
0
12
0.00
0.21
0.0
1.0
—
501.33
—
0
6
0
12
0.00
0.21
0.0
1.1
—
33.50
—
0
6
10
80
1.26
0.21
1.8
3.1
561.60
191.37
ng/l
—
10
71
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
23
204
1.15
0.19
3.5
4.6
3.88
7.83
umol/l
1.47
17
180
5
66
0.75
0.17
1.0
1.3
—
—
—
0
0
17
150
1.15
0.15
15.6
8.3
—
—
—
0
0
38
406
0.92
0.14
3.9
4.5
25.59
21.55
%
0.95
19
191
136
1385
0.92
0.13
5.0
4.8
1.99
1.95
mu/l
0.12
127
1279
54
514
1.07
0.13
4.4
5.4
2.19
2.52
ug/l
0.15
49
461
29
270
1.09
0.11
4.1
3.0
1389.22
351.61
ng/l
0.55
23
191
5
44
1.14
0.10
1.2
1.3
1.01
0.78
nmol/l
—
5
36
20
184
1.10
0.09
1.7
1.5
—
—
—
0
0
29
307
0.93
0.08
3.2
3.0
0.63
0.74
ug/l
0.44
19
186
5
63
0.79
0.08
1.4
2.2
—
—
—
0
0
27
254
1.07
0.08
1.4
1.3
9.90
34.33
iu/ml
—
6
75
13
119
1.10
0.06
1.2
1.5
—
—
—
0
0
46
475
0.96
0.06
1.6
1.5
0.62
1.39
u/ml
1.22
17
112
169
1683
1.07
0.02
52.2
23.8
4.38
4.56
e12/l
2.93
164
1644
14
134
1.05
0.00
1.4
2.4
—
—
—
0
0
42
414
1.02
0.00
1.5
1.9
—
—
—
0
0
13
129
1.01
0.00
1.8
1.4
224.46
566.09
u/ml
0.77
13
119
24
236
1.02
0.00
1.5
1.3
1.86
6.99
u/ml
—
7
87
115
1151
1.00
0.00
6.1
4.3
17.04
10.56
mm/h
2.49
109
1078
0
6
0.00
0.00
0.0
1.0
—
159.17
—
0
6
0
6
0.00
0.00
0.0
2.5
—
199.88
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
103.67
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
22.2
—
9.26
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
0.98
—
0
5
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
—
—
0
0
5
55
0.91
-0.00
1.8
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
116
1160
1.00
-0.00
4.2
4.0
14.87
14.75
pmol/l
0.23
111
1059
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.4
—
25.00
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
30.73
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
0.88
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY | 3.495 [2.57, 4.75] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.485 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 613 females with Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY | 2.759 [2.09, 3.65] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 799 males with Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY died.
Mortality risk
Mortality risk for people of age
years, who have Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.299% | 0.571% |
| 5 | 2.066% | 2.868% |
| 10 | 5.114% | 7.129% |
| 15 | 10.314% | 13.517% |
| 20 | 17.723% | 22.645% |
Relationships between endpoints
↥Index endpoint: Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY – Renal agenesis and other reduction defects of kidney
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data