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Pectus excavatum

Endpoint Browser PheWeb

Q17_PECTUS_EXCAVATUM

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q67.6
  • Cause of death: ICD-10 — Q67.6

2 out of 7 registries used, show all original rules.

195

4. Check minimum number of events

None

195

5. Include endpoints

None

195

6. Filter based on genotype QC (FinnGen only)

175

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Similar endpoints

↥

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 175 66 109
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 17.18 19.32 15.88

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
190
Matched controls
1900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q67.6
ICD-10 Finland
Pectus excavatum
+∞
272.7
190
*
GAF03
NOMESCO Finland
Correction of pectus excavatum
+∞
69.1
62
*
GAF10
NOMESCO Finland
Removal of prosthetic material after correction of malformation of chest wall
+∞
67.9
61
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
15.8
34.8
32
24
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.5
25.4
49
96
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
20.0
94
372
WX408
NOMESCO Finland
General anesthesy, balanced
3.7
16.1
71
263
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.2
14.7
47
138
75630
ICD-8 Finland
Other congenital anomalies of musculoskeletal system, Pectus excavatum
+∞
13.7
13
*
7548A
ICD-9 Finland
Certain congenital musculoskeletal deformities, Other specified nonteratogenic anomalies[PECTUS EXCAVATUM]
+∞
12.6
12
*
XF404
NOMESCO Finland
Ambulatory ECG
6.4
12.6
22
38
Z31.5
ICD-10 Finland
Genetic counselling
4.8
11.8
29
69
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.5
11.6
24
49
GAF96
NOMESCO Finland
Other correction of malformation of chest wall
+∞
10.5
10
*
Q67.7
ICD-10 Finland
Pectus carinatum
58.0
9.8
11
*
5853
FHL
Anterior thoracoplasty (funnel breast, chicken breast)
+∞
9.4
9
*
GAD00
NOMESCO Finland
Thoracoplasty without plombage
+∞
8.4
8
*
5859
FHL
Other operations in this group (eg removal of fixation plate)
+∞
7.3
7
*
ZXE20
NOMESCO Finland
More than three and less than five hours
3.4
6.9
26
84
R06.0
ICD-10 Finland
Dyspnoea
2.6
6.5
46
211
L04
ICPC
Chest symptom/complaint
3.5
6.4
23
72
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
6.1
59
311

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
78
403
2.59
8.99
12.2
5.1
1.22
1.07
inr
1.94
71
335
28
96
3.25
6.76
5.6
17.9
2.01
0.64
mmol/l
0.85
23
78
28
97
3.21
6.65
5.6
17.9
7.42
7.41
ph
0.20
13
51
16
52
3.27
4.19
4.7
20.8
0.59
0.69
%
0.56
16
52
65
413
1.87
3.86
2.2
2.3
—
—
—
0
0
16
55
3.08
3.84
5.1
19.8
0.96
1.45
%
1.96
16
55
100
734
1.77
3.63
4.3
6.3
5.86
6.31
mmol/l
2.42
90
663
108
814
1.76
3.55
3.6
2.6
—
—
—
0
0
16
58
2.92
3.52
5.1
18.9
95.76
94.28
%
0.44
16
58
175
1561
2.53
3.15
12.9
10.7
26.86
21.90
mg/l
1.14
139
1175
34
187
2.00
3.04
1.4
1.3
—
—
—
0
0
5
7
7.30
2.56
1.8
2.0
20.10
17.42
ug/l
—
5
7
161
1428
1.84
2.37
12.9
11.1
3.89
3.91
mmol/l
0.35
156
1386
67
486
1.58
2.29
5.6
5.5
38.67
38.60
g/l
0.03
59
463
161
1433
1.81
2.28
12.6
11.0
139.90
139.72
mmol/l
0.62
156
1396
43
279
1.70
2.28
1.6
2.3
1.40
1.36
mg/l
0.03
24
194
6
15
4.09
2.05
1.7
1.1
—
—
—
0
0
73
557
1.50
1.94
6.2
9.5
1.20
1.22
mmol/l
1.15
64
487
7
22
3.26
1.90
1.1
1.2
168.33
219.34
pmol/l
—
7
22
22
124
1.88
1.85
1.2
1.2
—
—
—
0
0
12
53
2.35
1.85
6.0
13.1
—
—
—
0
0
22
126
1.84
1.77
1.7
1.3
82.77
480.51
u/ml
1.17
22
120
50
358
1.54
1.76
2.8
2.4
22.85
13.18
ng/l
0.74
26
167
173
1602
1.89
1.75
9.6
9.0
26.65
31.19
u/l
2.61
168
1559
22
134
1.73
1.47
5.4
11.7
104.73
104.86
mmol/l
0.06
22
134
6
22
2.78
1.44
1.0
1.0
—
—
—
0
0
115
995
1.39
1.42
7.3
7.2
86.35
82.90
u/l
0.26
110
937
38
274
1.48
1.29
2.4
2.2
—
—
—
0
0
15
85
1.83
1.27
4.7
6.3
—
—
—
0
0
63
502
1.38
1.25
6.6
9.3
1.20
1.22
mmol/l
1.43
57
472
173
1632
1.67
1.21
12.6
8.5
—
—
—
0
0
20
126
1.66
1.20
1.7
1.6
—
—
—
0
0
57
453
1.37
1.14
1.9
1.7
—
—
—
0
0
65
530
1.34
1.10
1.5
1.7
—
—
—
0
0
6
122
0.48
1.10
2.0
2.7
—
—
—
0
0
5
21
2.42
1.09
1.8
1.5
0.46
0.40
e9/l
—
5
21
72
602
1.32
1.02
3.0
2.8
—
—
estimate
—
0
0
36
272
1.40
0.97
3.4
3.9
—
—
—
0
0
48
385
1.33
0.90
5.0
4.7
—
—
—
0
0
16
104
1.59
0.88
1.8
1.4
1131.59
995.12
nmol/l
—
8
82
89
778
1.27
0.87
6.0
7.0
32.26
30.88
%
0.55
84
749
8
45
1.81
0.85
4.0
4.6
36.77
36.97
°c
—
8
45
6
31
1.97
0.85
2.3
2.0
—
—
—
0
0
24
173
1.44
0.84
4.2
3.3
3.86
5.60
e9/l
0.69
18
156
24
174
1.43
0.82
2.4
1.6
—
—
—
0
0
41
326
1.33
0.81
2.3
3.6
7.38
7.39
ph
1.59
27
232
25
183
1.42
0.81
3.2
2.6
—
—
—
0
0
145
1355
1.30
0.77
4.4
4.5
1.68
1.80
mu/l
1.00
133
1277
21
151
1.44
0.75
3.0
7.0
3.08
1.29
mmol/l
1.29
21
123
13
84
1.59
0.74
1.3
1.2
—
—
—
0
0
82
723
1.24
0.71
2.7
3.1
0.00
0.00
estimate
-0.00
18
147
14
94
1.53
0.69
1.4
1.8
6.07
6.24
ph
—
7
62
85
756
1.22
0.67
7.6
9.0
0.00
0.00
e9/l
0.50
72
590
93
835
1.22
0.67
6.6
7.6
0.21
0.18
e9/l
0.39
87
724
21
155
1.40
0.66
3.3
7.1
7.38
7.37
ph
—
8
100
5
29
1.74
0.64
3.0
10.5
77.34
62.86
%
—
5
29
19
139
1.41
0.63
3.3
2.6
314.56
6754.77
u/l
—
5
58
81
721
1.22
0.63
2.7
3.0
0.00
0.00
estimate
-0.00
18
146
46
386
1.25
0.62
1.9
2.9
54.62
57.21
u/l
0.27
37
362
5
30
1.68
0.62
10.2
4.8
4.17
3.57
e9/l
—
5
30
83
742
1.21
0.61
3.2
3.1
70.81
76.06
ug/l
0.19
77
711
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
40
331
1.26
0.60
2.6
2.5
2.46
2.51
mg/l
0.06
34
292
0
21
0.00
0.60
0.0
1.1
—
2.08
—
0
5
63
550
1.22
0.59
2.4
2.7
0.00
0.01
estimate
0.50
14
131
0
23
0.00
0.58
0.0
3.1
—
44.17
—
0
23
0
23
0.00
0.58
0.0
6.3
—
8.35
—
0
23
15
205
0.71
0.58
1.1
1.3
1.50
7.30
u/ml
—
7
86
123
1146
1.21
0.57
3.6
3.8
14.97
14.62
pmol/l
1.04
116
1052
11
158
0.68
0.55
1.5
1.9
—
—
—
0
0
132
1394
0.83
0.54
3.3
3.4
4.39
4.56
mmol/l
1.81
124
1339
89
809
1.19
0.54
6.6
7.2
0.53
0.55
e9/l
0.31
80
691
18
135
1.37
0.53
6.0
12.4
—
—
—
0
0
79
712
1.19
0.52
2.7
3.0
0.00
0.00
estimate
-0.00
18
154
100
920
1.18
0.52
4.4
3.7
—
—
—
0
0
16
118
1.39
0.52
2.4
7.3
25.66
23.83
mmol/l
1.25
16
118
43
366
1.23
0.51
2.7
3.1
0.00
0.01
estimate
0.50
17
143
5
84
0.58
0.46
1.4
1.7
—
—
—
0
0
132
1386
0.84
0.46
3.2
3.3
1.37
1.36
mmol/l
0.04
124
1323
7
50
1.42
0.45
2.0
1.8
—
—
—
0
0
88
808
1.17
0.45
6.7
7.2
0.04
0.04
e9/l
0.45
79
688
10
69
1.47
0.45
2.0
3.7
—
—
—
0
0
91
840
1.16
0.43
6.6
7.2
2.00
1.99
e9/l
0.07
83
741
5
32
1.58
0.42
9.0
6.3
—
—
—
0
0
12
160
0.73
0.41
1.2
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
0.18
—
0
12
72
656
1.16
0.40
2.0
2.5
—
—
—
0
0
5
35
1.44
0.39
1.0
1.4
244.80
304.89
mu/l
—
5
28
19
152
1.28
0.38
2.8
7.1
6.41
5.84
kpa
1.52
19
147
134
1397
0.86
0.38
3.2
3.6
2.64
2.78
mmol/l
1.38
126
1334
45
506
0.85
0.37
1.8
1.8
—
—
—
0
0
6
42
1.44
0.36
8.7
3.9
58.33
54.98
%
—
6
42
49
440
1.15
0.33
1.6
2.1
—
—
—
0
0
34
297
1.18
0.32
2.1
2.4
—
—
—
0
0
7
53
1.33
0.31
3.9
7.1
0.70
0.58
%
—
7
53
19
157
1.23
0.31
1.4
1.9
—
—
—
0
0
42
468
0.87
0.31
1.9
1.5
1.74
2.11
g/l
1.29
26
289
7
55
1.28
0.30
4.1
6.9
1.33
1.81
%
—
7
55
7
57
1.24
0.29
1.3
1.2
—
—
—
0
0
7
57
1.24
0.29
1.3
1.2
—
—
—
0
0
48
435
1.14
0.29
1.4
1.6
92.26
97.49
pmol/l
0.28
29
230
46
417
1.14
0.27
2.2
2.5
—
0.29
—
0
7
58
625
0.90
0.25
2.2
2.1
—
—
—
0
0
12
97
1.25
0.23
1.2
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
72.50
—
0
10
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
3.5
—
1.53
—
0
12
0
12
0.00
0.21
0.0
5.4
—
2.92
—
0
12
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
122
1259
0.91
0.20
3.2
3.2
5.39
5.59
mmol/l
1.96
113
1173
40
432
0.91
0.18
1.6
1.7
—
—
—
0
0
46
429
1.10
0.17
2.0
2.3
0.00
0.00
estimate
-0.00
13
125
8
70
1.15
0.16
1.3
1.5
—
—
—
0
0
25
226
1.12
0.16
1.7
1.5
—
—
—
0
0
9
81
1.12
0.15
1.2
1.6
—
—
—
0
0
111
1138
0.94
0.12
2.5
3.4
28.52
34.06
u/l
0.92
105
1103
93
902
1.06
0.12
9.1
9.3
3.61
3.94
e9/l
1.12
84
770
63
604
1.06
0.12
2.7
2.8
6.17
6.24
ph
0.22
32
340
22
239
0.91
0.11
1.3
2.0
—
—
—
0
0
51
487
1.06
0.11
2.7
3.7
41.28
50.60
e6/l
0.10
32
329
55
527
1.06
0.10
1.6
1.6
7.68
2.11
u/ml
0.41
13
131
11
96
1.15
0.10
1.2
1.2
—
—
—
0
0
17
154
1.11
0.10
2.1
1.5
407.76
82979195.50
pmol/l
0.50
17
141
54
519
1.06
0.09
6.9
7.2
—
—
—
0
0
44
460
0.94
0.09
6.1
6.2
—
—
—
0
0
6
56
1.07
0.09
1.0
1.2
—
—
—
0
0
128
1298
0.96
0.07
2.7
3.0
1.08
1.23
mmol/l
1.88
117
1230
8
94
0.84
0.07
5.9
6.4
74.75
66.57
ng/l
—
8
87
34
355
0.95
0.06
1.9
3.2
0.11
0.24
e6/l
0.92
21
262
24
227
1.07
0.06
1.1
1.3
13.12
20.13
iu/ml
—
6
60
22
208
1.07
0.05
7.6
2.9
105.73
842.18
ng/l
0.62
11
110
42
406
1.04
0.05
2.2
3.2
14.17
27.84
e6/l
0.92
30
314
24
252
0.95
0.05
4.4
4.7
6.17
18.38
mg/mmol
0.88
15
187
151
1498
1.04
0.04
16.4
13.4
335.48
335.71
g/l
0.12
151
1489
19
198
0.96
0.02
1.5
2.5
—
—
—
0
0
26
252
1.04
0.02
1.2
1.3
—
—
—
0
0
29
298
0.97
0.02
1.3
1.9
—
—
—
0
0
13
123
1.06
0.01
2.5
2.8
—
—
—
0
0
12
127
0.94
0.01
1.2
1.2
—
—
—
0
0
10
94
1.07
0.01
1.1
1.1
3.43
2.97
u/ml
—
5
64
34
346
0.98
0.00
1.8
1.7
—
—
—
0
0
27
274
0.98
0.00
2.1
2.5
13.74
5.24
e6/l
0.65
27
248
30
296
1.02
0.00
1.3
1.9
—
—
—
0
0
30
296
1.02
0.00
1.3
2.0
—
—
—
0
0
38
376
1.01
0.00
2.7
2.6
1.02
1.02
kg/l
0.31
23
232
25
251
1.00
0.00
3.1
4.1
41.06
99.39
mg/l
0.93
14
192
31
313
0.99
0.00
3.4
3.1
116.08
140.14
ug/g
0.15
25
240
20
195
1.03
0.00
1.3
1.2
—
—
—
0
0
13
135
0.96
0.00
4.5
2.6
8.41
10.52
g/l
1.27
13
129
28
278
1.01
0.00
1.3
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
4.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
1999.38
—
0
8
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.0
—
12.44
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
0.00
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
7.90
—
0
6
0
5
0.00
-0.00
0.0
5.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
69
0.87
-0.00
1.2
1.2
—
—
—
0
0
30
300
1.00
-0.00
1.3
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
23.38
—
0
5
7
78
0.89
-0.00
1.1
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
19.87
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
284.20
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: Q17_PECTUS_EXCAVATUM – Pectus excavatum

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).