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Other congenital malformations of limb(s)

EFO Endpoint Browser PheWeb

Q17_OTHER_CONGEN_MALFO_LIMBS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q74
  • Cause of death: ICD-10 — Q74

2 out of 7 registries used, show all original rules.

333

4. Check minimum number of events

None

333

5. Include endpoints

None

333

6. Filter based on genotype QC (FinnGen only)

299

Control definitions (FinnGen only)

Control exclude
Q17_CONGEN_MALFO_DEFORMAT_MUSCULOS_SYSTEM

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q6[5-9]|Q7
Name in latin
Aliae malformationes congenitae membrorum

Similar endpoints

↥

List of similar endpoints to Other congenital malformations of limb(s) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4390 2208 2179
Only index persons 3749 1902 1847
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.06
Only index persons 0.07 0.07 0.07
Median age at first event (years)
Whole population 10.78 11.62 9.91
Only index persons 11.95 12.39 11.49

-FinnGen-

Key figures

All Female Male
Number of individuals 299 211 88
Unadjusted period prevalence (%) 0.06 0.07 0.04
Median age at first event (years) 14.99 14.85 15.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
312
Matched controls
3120
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q74.1
ICD-10 Finland
Congenital malformation of knee
+∞
86.6
79
*
Q74.88
ICD-10 Finland
Other specified congenital malformations of limb(s)
479.6
43.3
42
*
Q74.83
ICD-10 Finland
Congenital limb asymmetri, unspecified
+∞
35.1
33
*
Q74.9
ICD-10 Finland
Unspecified congenital malformation of limb(s)
+∞
29.7
28
*
NFK20
NOMESCO Finland
Epiphysiodesis of femur
147.3
26.0
27
*
Q74.81
ICD-10 Finland
Congenital overgrowth of limb(s)
+∞
25.4
24
*
Q74.01
ICD-10 Finland
Madelung's deformity
+∞
22.1
21
*
Z31.5
ICD-10 Finland
Genetic counselling
4.9
21.6
53
125
Q74.3
ICD-10 Finland
Arthrogryposis multiplex congenita
+∞
18.9
18
*
Q74.80
ICD-10 Finland
Congenital brachydactyli
+∞
17.9
17
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
7.3
17.7
27
40
NGU20
NOMESCO Finland
Removal of internal fixation device from knee or lower leg
15.3
17.2
28
20
Q74.82
ICD-10 Finland
Congenital undergrowth of limb(s)
+∞
16.8
16
*
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
28.0
15.8
21
8
NGK20
NOMESCO Finland
Epiphysiodesis of knee or lower leg
168.1
15.6
16
*
Q74.28
ICD-10 Finland
Other congenital malformations of lower limb(s), including pelvic girdle
+∞
14.7
14
*
NFK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of femur
56.0
13.9
16
*
Q68.8
ICD-10 Finland
Other specified congenital musculoskeletal deformities
+∞
13.6
13
*
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
6.5
13.6
23
38
ZXE20
NOMESCO Finland
More than three and less than five hours
3.7
13.5
47
143
R4120
NOMESCO Finland
Occupational therapy
4.4
13.0
35
88
L82
ICPC
Congenital anomaly musculoskeletal
+∞
12.6
12
*
R4110
NOMESCO Finland
Physiotherapy
2.6
12.6
96
457
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
12.6
113
581
Q74.00
ICD-10 Finland
Accessory carpal bones
+∞
11.5
11
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
11.4
117
633
Q66.0
ICD-10 Finland
Talipes equinovarus
+∞
10.5
10
*
SPAT1229
SPAT
Assessment of need for aid
5.6
10.3
20
38
ZXA05
NOMESCO Finland
Left side
2.8
10.1
58
237
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.4
9.1
73
350
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.1
8.9
39
137
Z3226
NOMESCO Finland
Physiotherapist
2.4
8.8
69
327
N02AX02
ATC
tramadol; systemic, rectal
2.2
8.8
99
548
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
8.8
87
457
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
4.6
8.8
21
48
M21.0
ICD-10 Finland
Valgus deformity, not elsewhere classified
51.5
8.7
10
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.2
8.7
36
122
NGK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of knee or lower leg
22.7
8.1
11
5
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.5
8.1
20
47
M21.7
ICD-10 Finland
Unequal limb length (acquired)
15.5
7.8
12
8
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
25.7
7.6
10
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
7.5
34
121
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
7.5
32
110
Q66.8
ICD-10 Finland
Other congenital deformities of feet
82.0
7.4
8
*
WX402
NOMESCO Finland
General anaesthesia
2.1
7.4
84
462
Q74.02
ICD-10 Finland
Cleidocranial dysostosis
+∞
7.3
7
*
Q66.9
ICD-10 Finland
Congenital deformity of feet, unspecified
+∞
7.3
7
*
Q68.1
ICD-10 Finland
Congenital deformity of hand
+∞
7.3
7
*
ZXA00
NOMESCO Finland
Right side
2.4
7.3
58
276
M25.5
ICD-10 Finland
Pain in joint
2.0
7.2
112
691
Z3229
NOMESCO Finland
Other healthcare associate professional
2.9
7.0
35
132
N06AX21
ATC
duloxetine; oral
2.6
7.0
42
175
ZXA10
NOMESCO Finland
Bilateral
2.3
6.8
56
269
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
7.4
6.8
15
21
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.6
6.7
41
172
R60.0
ICD-10 Finland
Localized oedema
3.0
6.6
30
107
Z50.1
ICD-10 Finland
Other physical therapy
4.2
6.4
17
42
M22.1
ICD-10 Finland
Recurrent subluxation of patella
18.5
6.3
9
5
Q74.8
ICD-10 Finland
Other specified congenital malformations of limb(s)
+∞
6.3
6
*
9472
FHL
Soft tissue biopsy (muscle, tumor) under general anesthesia or operating room
+∞
6.3
6
*
7558A
ICD-9 Finland
Other congenital anomalies of limbs, Other specified anomalies of unspecified limb[ARTHROGRYPOSIS MULTIPLEX CONGENITA]
+∞
6.3
6
*
TNH36
NOMESCO Finland
Custom molded cast of pes equinovarus
+∞
6.3
6
*
Q74.20
ICD-10 Finland
Congenital fusion of sacroiliac joint
+∞
6.3
6
*
Q74.2
ICD-10 Finland
Other congenital malformations of lower limb(s), including pelvic girdle
+∞
6.3
6
*
M41.5
ICD-10 Finland
Other secondary scoliosis
+∞
6.3
6
*
N03AX12
ATC
[U] gabapentin; oral
2.6
6.3
39
165
R52.2
ICD-10 Finland
Other chronic pain
5.6
6.2
17
32
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.7
6.1
34
136
N03AX16
ATC
[U] pregabalin
2.3
6.1
51
247

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
88
479
2.17
8.05
3.8
3.8
—
—
—
0
0
39
157
2.70
6.92
5.6
5.8
82.49
69.41
ng/l
0.23
39
147
57
286
2.21
6.27
2.6
2.0
—
—
—
0
0
104
686
1.77
5.10
3.2
3.4
8.50
8.78
mmol/l
0.18
96
617
112
758
1.75
5.01
4.4
3.2
18.14
52.20
e6/l
1.81
84
547
54
297
1.99
4.63
2.1
2.1
386.73
392.87
nmol/l
0.06
49
278
49
263
2.02
4.50
1.3
1.2
—
—
—
0
0
98
656
1.72
4.48
4.3
3.2
0.32
0.22
e6/l
0.29
67
459
181
1422
1.65
4.46
8.0
7.4
0.04
0.04
e9/l
0.06
156
1224
181
1422
1.65
4.46
8.0
7.4
0.55
0.53
e9/l
0.64
156
1227
130
942
1.65
4.39
17.3
8.5
1.21
1.22
mmol/l
1.03
123
886
86
559
1.74
4.35
4.1
3.6
7.38
7.39
ph
0.95
57
374
120
855
1.66
4.32
7.3
5.5
36.21
37.79
g/l
2.10
111
818
185
1475
1.62
4.18
8.2
7.8
0.19
0.18
e9/l
0.30
164
1301
194
1565
1.63
4.18
9.3
10.1
3.98
3.83
e9/l
0.46
168
1354
156
1197
1.61
4.11
3.0
2.8
—
—
estimate
—
0
0
185
1482
1.61
4.04
8.0
7.3
2.02
2.11
e9/l
0.50
164
1321
65
399
1.79
3.97
3.8
3.0
2.41
3.19
e6/l
0.48
31
193
53
314
1.83
3.63
1.9
1.5
—
—
—
0
0
172
1378
1.55
3.58
11.1
5.4
6.18
6.21
mmol/l
0.10
159
1238
74
487
1.68
3.52
3.5
2.7
5.62
8.01
e6/l
1.30
63
432
34
175
2.06
3.50
1.3
1.1
—
—
—
0
0
202
1684
1.57
3.47
7.8
6.6
84.97
84.99
u/l
0.00
197
1592
99
704
1.60
3.46
2.5
2.7
2.38
2.36
mmol/l
0.50
90
654
14
47
3.07
3.46
23.1
17.5
74.23
70.02
%
0.36
14
47
112
824
1.56
3.37
5.8
6.3
—
—
—
0
0
124
939
1.53
3.25
5.7
3.9
46.65
41.41
e6/l
0.10
86
587
69
457
1.65
3.19
2.9
3.3
312.92
312.05
umol/l
0.03
62
421
78
533
1.62
3.18
3.3
2.6
1.32
0.92
mg/l
0.55
59
383
45
267
1.80
3.07
1.3
1.2
—
—
—
0
0
12
36
3.42
3.05
2.8
1.1
—
—
—
0
0
121
926
1.50
2.96
7.9
7.9
—
—
—
0
0
29
151
2.01
2.91
28.3
9.9
96.66
96.32
%
0.13
29
144
163
1331
1.47
2.86
8.1
7.5
8.33
8.24
%
0.18
155
1274
25
124
2.10
2.85
14.3
15.8
1.12
1.09
mg/l
0.12
25
118
167
1371
1.47
2.84
8.0
7.2
55.33
54.09
%
0.83
161
1329
26
133
2.04
2.74
31.2
10.4
120.12
122.08
g/l
0.18
26
127
30
162
1.94
2.73
27.5
9.5
-0.75
0.75
mmol/l
1.40
22
134
64
434
1.60
2.67
4.3
4.4
2.37
11.47
mg/mmol
2.96
47
284
21
100
2.18
2.65
16.8
11.1
0.65
0.59
%
0.28
21
100
161
1325
1.44
2.63
8.2
7.5
0.57
0.67
%
1.88
154
1260
7
15
4.75
2.61
1.1
1.7
7.10
8.67
u/l
—
7
15
168
1396
1.44
2.60
7.9
7.3
30.72
31.81
%
0.76
162
1347
54
354
1.64
2.58
1.7
1.5
422.19
21338021.20
pmol/l
0.50
42
314
132
1052
1.44
2.54
14.0
8.0
1.21
1.22
mmol/l
0.92
122
934
38
228
1.76
2.51
18.9
11.2
105.53
104.93
mmol/l
0.40
38
228
39
236
1.75
2.50
13.4
7.6
4.97
4.99
kpa
0.08
39
229
29
160
1.90
2.49
28.5
9.6
7.40
7.43
ph
1.17
14
77
53
349
1.62
2.49
2.2
2.1
2.45
2.42
mmol/l
1.33
43
307
142
1152
1.43
2.46
3.8
2.7
69.52
69.98
nmol/l
0.09
137
1080
160
1327
1.42
2.45
8.2
7.4
2.87
2.87
%
0.01
152
1266
109
843
1.45
2.44
1.9
1.7
100.61
97.59
pmol/l
0.27
51
442
62
428
1.56
2.40
3.4
2.6
564.68
554.58
mosm/kgh2o
0.09
51
368
43
272
1.67
2.36
1.4
1.4
—
—
—
0
0
268
2466
1.62
2.29
20.3
11.4
3.90
3.90
mmol/l
0.02
263
2396
62
434
1.53
2.25
3.2
3.7
40.83
91.27
mg/l
1.13
46
291
73
531
1.49
2.22
2.9
3.1
111.25
82.87
ug/g
0.37
62
414
44
285
1.63
2.21
13.5
8.8
7.38
7.37
ph
0.53
27
166
36
221
1.71
2.21
15.2
9.7
24.45
23.73
mmol/l
1.02
36
221
19
94
2.09
2.21
35.8
12.1
22.58
24.42
mmol/l
1.86
19
94
43
278
1.63
2.18
13.6
9.0
1.66
1.08
mmol/l
0.83
38
231
9
30
3.06
2.16
3.7
4.5
9.56
9.93
%
—
9
30
9
30
3.06
2.16
3.7
4.9
24.67
12.23
%
—
9
30
9
30
3.06
2.16
3.7
4.5
20.67
27.63
%
—
9
30
40
255
1.65
2.14
14.3
9.1
5.30
4.99
kpa
0.39
40
250
31
185
1.75
2.10
2.8
2.0
6.23
6.29
ph
0.15
22
120
91
701
1.42
2.04
3.4
2.3
—
—
—
0
0
41
269
1.60
1.97
1.3
1.4
—
—
—
0
0
36
229
1.65
1.95
1.6
1.9
13.98
15.12
iu/l
0.10
26
177
6
16
3.80
1.94
2.5
1.6
—
—
—
0
0
8
28
2.90
1.87
2.6
3.2
17.88
17.29
%
—
8
28
38
250
1.59
1.81
24.6
10.7
—
—
—
0
0
8
29
2.80
1.80
3.5
1.3
—
—
—
0
0
11
47
2.39
1.79
1.1
1.1
—
—
—
0
0
100
800
1.37
1.77
2.7
2.3
—
—
—
0
0
7
24
2.96
1.73
4.0
1.3
—
—
nmol/l
—
0
0
25
149
1.74
1.73
1.4
1.2
—
—
—
0
0
11
48
2.34
1.72
29.2
17.5
79.73
70.57
%
1.22
11
48
152
1300
1.33
1.72
12.5
10.2
0.00
0.00
e9/l
0.50
121
1044
10
40
2.55
1.68
2.8
4.2
94.50
91.51
%
—
10
40
93
744
1.36
1.63
9.2
7.9
1.12
1.11
inr
0.10
80
624
5
14
3.61
1.62
2.2
2.1
76.60
156.14
nmol/l
—
5
14
30
192
1.62
1.61
2.1
1.9
0.00
0.00
estimate
—
6
51
112
927
1.32
1.56
1.8
1.9
1.39
1.32
mmol/l
0.43
103
832
71
549
1.38
1.54
1.7
1.5
20.53
19.83
nmol/l
0.15
64
481
7
27
2.63
1.52
2.4
2.0
1.21
1.63
mmol/l
—
7
27
260
2433
1.41
1.47
21.4
14.5
13.43
13.18
%
2.24
255
2415
88
709
1.34
1.46
2.8
2.7
2.51
2.47
mg/l
0.05
80
617
6
22
2.76
1.44
3.3
2.5
—
—
—
0
0
81
650
1.33
1.38
3.2
3.0
1.02
1.02
kg/l
0.33
48
400
29
192
1.56
1.38
1.6
2.0
7.50
7.79
u/l
0.05
20
141
10
47
2.16
1.35
3.3
2.0
—
—
—
0
0
159
1400
1.28
1.34
4.1
3.4
0.00
0.00
estimate
-0.00
23
275
40
286
1.46
1.34
4.0
4.5
5.46
8.26
umol/l
0.87
32
238
158
1393
1.27
1.31
4.0
3.3
0.00
0.00
estimate
-0.00
27
284
11
55
2.04
1.29
1.6
1.7
15.73
22.81
ng/l
1.22
11
55
66
519
1.34
1.29
1.7
1.7
—
—
—
0
0
8
35
2.32
1.28
3.5
3.9
39.48
39.25
%
—
8
35
231
2139
1.31
1.27
5.0
4.4
14.37
14.42
pmol/l
0.15
218
1987
34
238
1.48
1.27
1.6
1.4
247.62
317.03
mu/l
1.61
34
217
30
205
1.51
1.25
3.0
4.5
0.24
0.22
g/l
0.57
30
195
5
19
2.66
1.22
2.0
1.7
91.58
92.74
%
—
5
19
28
190
1.52
1.21
17.5
8.0
—
—
—
0
0
13
72
1.84
1.17
11.1
3.7
—
—
—
0
0
155
1379
1.25
1.14
4.0
3.3
0.00
0.00
estimate
-0.00
27
291
132
1154
1.25
1.13
3.4
3.0
6.15
6.28
ph
0.68
73
607
7
31
2.29
1.11
44.9
23.0
12.76
11.54
%
—
7
31
32
229
1.44
1.09
1.5
1.4
—
—
—
0
0
19
121
1.61
1.08
1.3
1.4
—
—
—
0
0
10
52
1.95
1.07
3.8
1.9
0.30
0.92
ug/l
—
10
47
35
256
1.41
1.06
1.6
1.6
—
—
—
0
0
27
188
1.48
1.05
2.8
1.9
1.06
1.17
g/l
0.37
27
176
286
2755
1.46
1.04
14.0
9.1
—
—
—
0
0
7
34
2.08
1.03
1.4
1.2
—
—
—
0
0
43
331
1.35
0.98
1.5
1.6
—
—
—
0
0
218
2032
1.24
0.98
5.5
4.2
36.71
36.65
mmol/mol
0.03
211
1938
7
37
1.91
0.94
2.4
1.4
—
—
—
0
0
7
37
1.91
0.94
2.4
1.4
—
—
—
0
0
7
37
1.91
0.94
2.4
1.4
—
—
—
0
0
7
37
1.91
0.94
2.4
1.4
—
—
—
0
0
50
399
1.30
0.90
1.5
1.5
257.14
515.50
titre
—
7
80
74
621
1.25
0.89
2.7
2.5
206.27
24.82
ng/l
0.46
37
271
45
355
1.31
0.88
3.0
2.5
8125.53
3995.88
u/l
0.31
18
154
103
899
1.22
0.87
1.9
1.5
2.19
1.93
g/l
0.64
65
547
26
188
1.42
0.86
1.8
1.3
—
—
—
0
0
95
823
1.22
0.86
3.4
2.7
—
0.20
—
0
10
19
130
1.49
0.83
1.0
1.1
—
—
—
0
0
101
884
1.21
0.82
1.8
1.8
—
—
—
0
0
279
2694
1.34
0.82
11.8
9.1
28.80
25.22
u/l
1.49
273
2627
6
32
1.89
0.82
1.5
1.2
—
—
—
0
0
232
2194
1.22
0.82
4.2
3.4
5.58
5.54
mmol/l
0.20
215
2049
18
123
1.49
0.79
5.1
3.2
1.21
1.23
mmol/l
0.41
13
101
194
1809
1.19
0.77
3.6
3.4
41.52
31.52
u/l
0.93
186
1753
113
1006
1.19
0.76
1.7
1.6
0.64
2.70
u/ml
2.52
26
253
78
673
1.21
0.73
5.2
4.3
—
—
—
0
0
16
110
1.48
0.70
2.1
1.7
—
—
—
0
0
5
27
1.87
0.68
1.2
1.2
—
—
—
0
0
13
86
1.53
0.67
1.2
1.3
—
—
—
0
0
5
28
1.80
0.66
5.4
4.7
1.60
2.36
ug/l
—
5
28
22
164
1.37
0.64
1.6
2.5
—
—
—
0
0
58
493
1.22
0.64
1.4
1.3
10.84
22.13
iu/ml
1.65
11
132
115
1040
1.17
0.63
1.7
1.8
—
—
—
0
0
42
346
1.25
0.61
4.5
2.7
184.92
491.99
ng/l
0.84
26
180
5
30
1.68
0.61
1.0
1.2
0.45
1.38
u/ml
—
5
23
0
20
0.00
0.60
0.0
1.1
—
32.07
—
0
20
8
52
1.55
0.60
2.4
4.5
3.35
8.93
u/ml
—
8
52
6
35
1.73
0.58
8.7
3.1
—
—
—
0
0
73
824
0.85
0.56
2.3
1.9
—
—
—
0
0
9
60
1.51
0.55
1.1
1.9
—
—
—
0
0
11
74
1.50
0.54
4.6
5.7
36.58
36.92
°c
0.80
11
74
253
2444
1.19
0.54
6.0
5.2
1.79
1.79
mu/l
0.04
241
2334
11
75
1.48
0.51
1.5
3.1
—
—
—
0
0
28
342
0.80
0.49
1.3
1.3
—
—
—
0
0
112
1030
1.14
0.48
3.3
3.0
0.00
0.01
estimate
0.80
22
251
32
267
1.22
0.44
2.0
1.9
—
—
—
0
0
274
2677
1.19
0.43
17.6
11.2
20.88
21.17
mg/l
0.05
223
2060
5
32
1.57
0.42
1.0
1.0
—
—
—
0
0
10
70
1.44
0.42
1.6
1.1
—
—
—
0
0
79
717
1.14
0.41
3.7
3.2
0.00
0.00
estimate
0.50
25
278
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
26
312
0.82
0.40
1.8
1.6
3.78
3.39
mmol/l
0.72
17
208
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
16
203
0.78
0.39
1.3
1.3
383.29
285.52
miu/ml
—
7
105
20
161
1.26
0.38
3.4
4.2
52.18
68.85
e9/l
2.58
11
106
5
37
1.36
0.37
4.8
3.9
6.40
7.69
pmol/l
—
5
37
13
99
1.33
0.36
1.1
1.1
1.14
12.13
u/ml
—
7
52
41
360
1.16
0.34
1.4
1.3
—
—
—
0
0
6
47
1.28
0.32
1.8
4.1
—
—
—
0
0
17
138
1.25
0.31
1.5
1.6
—
—
—
0
0
7
57
1.23
0.29
1.0
1.1
—
—
—
0
0
33
290
1.15
0.28
1.3
1.3
93.38
143.93
u/ml
0.45
12
107
8
62
1.30
0.28
4.6
2.1
1.03
0.72
nmol/l
—
8
53
16
192
0.82
0.26
1.1
1.1
—
—
—
0
0
68
732
0.91
0.26
1.7
1.7
—
—
—
0
0
9
73
1.24
0.25
1.2
1.1
—
—
—
0
0
14
114
1.24
0.25
1.3
1.2
—
—
—
0
0
11
87
1.27
0.24
3.7
2.9
147.47
110.45
ng/l
0.11
11
82
17
201
0.84
0.24
1.5
1.6
—
—
—
0
0
37
333
1.13
0.23
2.4
2.1
—
—
—
0
0
5
39
1.29
0.23
1.4
1.2
55.80
39.62
nmol/l
—
5
34
5
40
1.25
0.22
1.8
1.6
0.52
0.51
e9/l
—
5
40
5
40
1.25
0.22
1.4
3.7
—
—
—
0
0
216
2110
1.08
0.22
3.6
3.2
1.27
1.17
mmol/l
1.17
206
2003
5
42
1.19
0.21
1.0
3.4
4.01
3.52
e9/l
—
5
42
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
5.24
—
0
11
0
10
0.00
0.21
0.0
7.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
9.50
—
0
14
17
197
0.86
0.20
1.5
1.5
—
—
—
0
0
12
99
1.22
0.20
1.1
1.1
0.05
0.40
u/ml
—
6
38
6
51
1.18
0.19
1.0
1.1
—
—
—
0
0
29
261
1.12
0.19
1.3
2.4
—
—
—
0
0
12
101
1.20
0.17
1.6
1.9
0.00
0.00
estimate
—
5
38
16
139
1.16
0.16
2.1
2.2
0.60
0.67
ug/l
—
5
63
32
293
1.10
0.16
1.3
2.1
—
—
—
0
0
299
2969
1.17
0.16
25.1
17.4
270.81
262.14
e9/l
1.48
294
2910
15
130
1.16
0.16
3.1
3.6
5.51
8.99
umol/l
—
10
97
8
73
1.10
0.16
7.0
7.6
—
—
—
0
0
9
82
1.10
0.15
2.2
1.9
—
—
—
0
0
231
2279
1.05
0.12
4.7
4.0
2.87
2.77
mmol/l
1.00
224
2175
11
126
0.87
0.11
1.0
1.0
—
0.67
—
0
15
12
105
1.15
0.11
1.9
1.6
122.00
130.85
au/ml
—
7
38
100
1030
0.96
0.11
2.9
2.3
—
—
—
0
0
35
372
0.93
0.11
1.5
1.9
—
—
—
0
0
13
146
0.89
0.10
1.1
1.1
0.07
2.34
u/ml
—
8
91
299
2974
1.13
0.10
25.0
17.3
4.61
4.57
e12/l
0.93
294
2913
231
2283
1.05
0.10
4.4
3.8
4.66
4.63
mmol/l
0.17
225
2187
5
46
1.09
0.09
1.0
1.3
0.91
2.23
u/ml
—
5
24
16
145
1.11
0.09
1.1
1.1
3.22
4.94
u/ml
—
9
101
13
116
1.13
0.09
1.1
1.1
0.15
6.40
u/ml
—
7
66
6
55
1.09
0.09
2.0
1.3
—
—
—
0
0
35
369
0.94
0.09
1.5
1.9
—
—
—
0
0
5
62
0.80
0.08
27.2
4.4
2.12
1.60
%
—
5
54
229
2267
1.04
0.08
4.2
3.7
1.39
1.46
mmol/l
2.04
222
2164
18
166
1.09
0.08
1.5
1.5
—
—
—
0
0
7
83
0.84
0.07
1.0
1.3
—
—
—
0
0
92
899
1.03
0.07
1.9
1.9
—
—
—
0
0
10
89
1.13
0.07
1.2
1.2
—
—
—
0
0
10
89
1.13
0.07
1.2
1.2
—
—
—
0
0
299
2978
1.10
0.06
25.1
17.4
7.06
6.76
e9/l
1.67
294
2913
12
109
1.10
0.06
2.2
1.6
—
—
—
0
0
36
372
0.96
0.04
1.5
1.9
—
—
—
0
0
49
478
1.03
0.04
1.3
1.3
2.87
8.72
u/ml
1.56
17
183
19
181
1.05
0.03
1.3
1.5
0.54
0.25
mg/l
—
6
71
36
370
0.97
0.03
1.5
1.9
—
—
—
0
0
10
93
1.08
0.02
1.5
1.1
—
—
—
0
0
12
127
0.94
0.01
1.0
1.0
1.40
1.54
g/l
1.14
12
127
80
807
0.99
0.01
3.0
2.6
0.00
0.00
estimate
0.50
21
239
13
128
1.02
0.00
1.2
1.1
0.78
0.89
g/l
0.95
13
128
14
142
0.99
0.00
1.1
1.1
0.35
1.26
u/ml
—
7
82
22
221
1.00
0.00
4.7
3.1
—
—
—
0
0
34
344
0.99
0.00
1.5
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
12.5
—
8.55
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
7.0
—
49.50
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.02
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
-0.00
1.2
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
113
1130
1.00
-0.00
2.6
2.4
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
68.00
—
0
8
0
9
0.00
-0.00
0.0
26.0
—
0.61
—
0
9
8
80
1.00
-0.00
1.4
1.2
—
—
—
0
0
8
83
0.96
-0.00
3.9
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
53.22
—
0
9
7
78
0.90
-0.00
1.0
2.5
58.66
56.01
%
—
7
78

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_OTHER_CONGEN_MALFO_LIMBS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have Q17_OTHER_CONGEN_MALFO_LIMBS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: Q17_OTHER_CONGEN_MALFO_LIMBS – Other congenital malformations of limb(s)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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