intestinal perforation: Opening or penetration through the wall of the INTESTINES.
Other congenital malformations of intestine
DOID EFO Endpoint Browser PheWeb
Q17_OTHER_CONGEN_MALFO_INTESTINE
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
353 |
4. Check minimum number of eventsNone |
353 |
5. Include endpointsNone |
353 |
6. Filter based on genotype QC (FinnGen only) |
316 |
Control definitions (FinnGen only)
- Control exclude
- Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM1
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q3[8-9]|Q4[0-5]
- Name in latin
- Aliae malformationes congenitae intestini
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of intestine
based on the number of shared cases.
Similar with more cases:
- Other congenital malformations of the digestive system
- Other congenital malformations of the digestive system, including avohilmo
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities, including avohilmo
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3727 | 1773 | 1940 |
| Only index persons | 3073 | 1448 | 1625 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 16.48 | 14.08 | 18.30 |
| Only index persons | 23.09 | 22.17 | 23.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 316 | 168 | 148 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.07 |
| Median age at first event (years) | 47.20 | 46.29 | 48.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 329
- Matched controls
- 3290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q43.0
ICD-10 Finland
Meckel diverticulum
+∞
200.1
171
*
JFB00
NOMESCO Finland
Partial resection of small intestine
36.1
80.8
52
17
Q43.8
ICD-10 Finland
Other specified congenital malformations of intestine
625.8
55.3
53
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
13.0
53.4
55
50
JFA73
NOMESCO Finland
Excision of lesion of small intestine
+∞
45.9
43
*
Q43.1
ICD-10 Finland
Hirschsprung disease
+∞
44.8
42
*
JEA00
NOMESCO Finland
Appendectomy
8.4
44.1
64
92
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
14.3
38.0
36
28
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.3
37.3
198
859
JAH00
NOMESCO Finland
Laparotomy
10.5
30.3
35
37
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.5
29.7
65
140
UJF32
NOMESCO Finland
Coloscopy
3.8
29.0
127
467
JAH01
NOMESCO Finland
Laparoscopy
7.8
26.5
39
56
P01AB01
ATC
metronidazole; oral, rectal
3.3
25.6
171
808
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
3.9
24.1
86
271
Q43.5
ICD-10 Finland
Ectopic anus
+∞
23.2
22
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
6.8
22.9
38
62
ZXD05
NOMESCO Finland
Urgent procedure
3.2
22.6
142
636
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.2
21.9
127
542
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
23.4
21.2
30
14
Q43.30
ICD-10 Finland
Template rotation of colon
+∞
20.0
19
*
TJF80
NOMESCO Finland
Ostomy education
29.9
19.0
25
9
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
18.7
127
583
ZXE10
NOMESCO Finland
More than one and less than three hours
2.8
18.6
153
777
JN3AD
NOMESCO Finland
Abdominal CT examination
3.5
16.2
63
207
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
16.1
15.1
24
16
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
14.9
75
288
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.7
14.6
100
453
TPH07
NOMESCO Finland
Cathetrisation of artery
3.4
14.6
59
198
ZXE20
NOMESCO Finland
More than three and less than five hours
3.2
14.2
67
247
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
13.7
96
438
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.0
13.0
40
111
A06AC01
ATC
ispaghula (psylla seeds); oral
2.6
12.9
99
471
K57.2
ICD-10 Finland
Diverticular disease of large intestine with perforation and abscess
11.7
12.7
23
21
Q43.9
ICD-10 Finland
Congenital malformation of intestine, unspecified
+∞
12.6
12
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.5
12.5
98
470
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
12.4
144
823
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
11.9
74
316
Q43.2
ICD-10 Finland
Other congenital functional disorders of colon
+∞
11.5
11
*
Q42.2
ICD-10 Finland
Congenital absence, atresia and stenosis of anus with fistula
+∞
11.5
11
*
TJD20
NOMESCO Finland
Change of gastrostomy tube
26.1
11.2
15
6
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
3.5
11.1
41
129
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
10.8
87
419
JDB00
NOMESCO Finland
Gastrostomy
62.1
10.7
12
*
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
12.6
10.5
18
15
Q42.0
ICD-10 Finland
Congenital absence, atresia and stenosis of rectum with fistula
+∞
10.5
10
*
WX882
NOMESCO Finland
High dependency care
4.1
10.4
29
75
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.7
10.3
34
99
K65.0
ICD-10 Finland
Acute peritonitis
24.3
10.3
14
6
J01MA02
ATC
ciprofloxacin; systemic
2.2
10.3
132
774
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.1
10.2
47
170
K56.2
ICD-10 Finland
Volvulus
17.4
10.0
15
9
K56.7
ICD-10 Finland
Ileus, unspecified
11.1
9.9
18
17
Z3226
NOMESCO Finland
Physiotherapist
2.4
9.9
82
399
N02AX02
ATC
tramadol; systemic, rectal
2.1
9.8
141
859
Z2446
NOMESCO Finland
Social worker
3.0
9.6
46
170
UJD02
NOMESCO Finland
Gastroscopy
4.1
9.4
27
71
Q42.3
ICD-10 Finland
Congenital absence, atresia and stenosis of anus without fistula
+∞
9.4
9
*
JFA74
NOMESCO Finland
Laparoscopic excision of lesion of small intestine
+∞
9.4
9
*
7513A
ICD-9 Finland
Other congenital anomalies of digestive system, Hirschsprung's disease and other congenital functional disorders of colon[MORBUS HIRSCHPRUNG]
+∞
9.4
9
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.7
9.2
19
23
WX002
NOMESCO Finland
Sedation and analgesia
2.4
9.1
72
342
Z2221
NOMESCO Finland
Medical doctor
2.2
9.0
107
602
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
9.0
161
1055
A03FA02
ATC
cisapride; oral, rectal
3.6
8.9
30
89
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.9
8.8
26
70
K92.1
ICD-10 Finland
Melaena
3.7
8.7
28
80
K59.0
ICD-10 Finland
Constipation
3.3
8.6
33
106
WX402
NOMESCO Finland
General anaesthesia
2.2
8.5
94
513
ZXE00
NOMESCO Finland
One hour or less
2.0
8.5
144
922
JGB20
NOMESCO Finland
Partial rectosigmoidectomy and abdominoperineal pull-through anastomosis
92.3
8.5
9
*
A06AD11
ATC
lactulose; oral
2.6
8.2
52
222
JF2AB
NOMESCO Finland
Colongraphy with X-ray
34.3
8.1
10
*
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
34.3
8.1
10
*
RD210, ,
NOMESCO Finland
4.2
7.9
21
52
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
7.9
64
306
K50.0
ICD-10 Finland
Crohn disease of small intestine
9.8
7.9
15
16
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
15.5
7.8
12
8
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.6
7.7
49
209
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.2
7.6
71
360
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
6.7
7.5
18
28
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.0
7.4
33
117
UJF30
NOMESCO Finland
Ileoscopy through colon
2.8
7.3
39
152
Q87.26
ICD-10 Finland
VATER association
+∞
7.3
7
*
6504
FHL
Reconstruction
+∞
7.3
7
*
368
Kela drug reimbursment
Combination product containing docusate sodium and sorbitol
+∞
7.3
7
*
A06AG10
ATC
docusate sodium, incl. combinations; rectal
+∞
7.3
7
*
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
16.2
7.3
11
7
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
7.2
45
190
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
30.7
7.2
9
*
D06
ICPC
Abdominal pain localized other
2.7
7.2
41
166
WX892
NOMESCO Finland
Monitored bed care
2.9
7.1
35
131
UJG02
NOMESCO Finland
Proctoscopy
7.8
7.0
15
20
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.6
6.9
41
169
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
17.1
6.8
10
6
JWA00
NOMESCO Finland
Repair of wound dehiscence in gastroenterological surgery
17.1
6.8
10
6
D37.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Small intestine
17.1
6.8
10
6
K57.9
ICD-10 Finland
Diverticular disease of intestine, part unspecified, without perforation or abscess
6.7
6.7
16
25
R10.0
ICD-10 Finland
Acute abdomen
5.7
6.7
18
33
K59.09
ICD-10 Finland
Constipation, unspecified
2.8
6.6
33
124
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.0
6.6
19
50
WX730
NOMESCO Finland
Conventional respirator
12.6
6.6
11
9
K57.1
ICD-10 Finland
Diverticular disease of small intestine without perforation or abscess
10.3
6.6
12
12
JFH10
NOMESCO Finland
Total colectomy and ileostomy
71.2
6.4
7
*
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
4.2
6.4
17
42
N30.0
ICD-10 Finland
Acute cystitis
2.2
6.3
59
299
D01
ICPC
Abdominal pain/cramps general
2.2
6.3
58
292
Z3231
NOMESCO Finland
Registered nurse
1.9
6.3
105
656
GD1RA
NOMESCO Finland
Dynamic X-ray examination of respiratory organs with convetional X-ray picture
+∞
6.3
6
*
JEW96
NOMESCO Finland
Other operation on appendix
+∞
6.3
6
*
R4110
NOMESCO Finland
Physiotherapy
1.9
6.2
101
624
N03AX11
ATC
topiramate; oral
4.3
6.2
16
39
R2110
NOMESCO Finland
Giving the first information
3.3
6.1
23
73
JHD00
NOMESCO Finland
Anal dilatation
12.8
6.1
10
8
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
6.1
76
429
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
189
1162
2.47
14.39
10.2
5.5
35.85
36.24
g/l
0.44
179
1103
217
1425
2.54
14.24
10.3
6.8
13.11
13.11
umol/l
0.00
206
1360
270
2045
2.79
11.94
12.9
7.7
87.66
84.65
u/l
0.39
264
1932
51
191
2.98
10.38
2.1
1.6
—
—
—
0
0
31
88
3.79
9.76
2.0
1.3
—
—
—
0
0
136
834
2.08
9.19
5.3
3.3
0.27
0.31
e6/l
0.13
110
599
157
1019
2.03
9.04
6.0
3.5
—
—
—
0
0
115
686
2.04
8.19
4.2
2.4
—
—
—
0
0
179
1251
1.95
8.01
4.5
2.7
73.24
73.74
nmol/l
0.09
164
1139
60
278
2.42
7.97
19.8
11.1
1.28
1.33
mmol/l
0.16
60
271
91
504
2.11
7.87
4.5
3.3
3.84
2.10
e6/l
0.48
49
251
226
1721
2.00
7.73
14.2
10.4
4.43
4.03
e9/l
1.38
196
1487
25
72
3.68
7.70
1.6
1.5
—
—
—
0
0
93
535
2.03
7.19
4.5
3.1
1.83
0.73
e6/l
0.84
53
278
58
278
2.32
7.11
6.0
3.0
0.23
0.22
g/l
0.29
53
261
190
1405
1.83
6.66
17.0
8.4
1.21
1.21
mmol/l
0.16
170
1238
58
289
2.22
6.46
18.1
6.1
24.30
23.70
mmol/l
1.05
58
289
79
444
2.03
6.45
2.1
2.0
—
—
—
0
0
143
979
1.81
6.39
6.7
3.3
31.86
31.43
u/l
0.06
133
931
155
1096
1.78
6.15
2.7
2.0
92.65
94.89
pmol/l
0.24
86
568
174
1283
1.76
5.89
4.4
2.9
—
—
estimate
—
0
0
68
374
2.03
5.85
19.1
5.8
1.64
1.18
mmol/l
0.65
59
311
69
382
2.02
5.83
19.3
5.8
5.87
5.71
kpa
0.96
69
371
56
288
2.14
5.75
3.7
2.5
31.57
29.79
u/l
0.21
49
233
69
385
2.00
5.70
21.9
8.8
105.58
104.52
mmol/l
1.24
69
385
173
1286
1.73
5.58
20.6
8.5
1.21
1.22
mmol/l
0.49
161
1205
211
1662
1.75
5.49
12.2
6.0
6.34
6.54
mmol/l
0.93
201
1572
51
261
2.13
5.29
13.6
6.0
1.86
1.24
mmol/l
1.05
40
198
28
114
2.59
4.86
1.5
1.3
—
—
—
0
0
95
620
1.75
4.74
3.2
2.2
0.90
1.13
mg/l
0.61
75
479
54
295
1.99
4.70
10.4
12.2
0.20
0.72
mmol/l
0.41
48
257
109
741
1.70
4.69
5.0
2.5
2.73
2.74
mg/l
0.01
102
639
189
1483
1.64
4.64
4.5
3.5
0.00
0.00
estimate
-0.00
44
281
82
518
1.78
4.56
5.1
3.9
522.56
414.65
ng/l
0.15
57
385
190
1499
1.63
4.51
4.7
3.5
0.00
0.00
estimate
-0.00
43
283
70
425
1.82
4.43
3.0
2.4
2.46
2.37
g/l
0.62
64
390
306
2777
2.46
4.40
33.4
17.0
139.32
139.66
mmol/l
1.75
298
2724
60
348
1.89
4.38
19.7
5.5
5.29
4.74
kpa
1.11
60
338
306
2778
2.45
4.37
33.6
17.1
3.98
3.97
mmol/l
0.38
299
2716
244
2062
1.71
4.33
5.4
4.3
11.62
10.39
mm/h
0.66
238
1928
190
1509
1.61
4.31
4.6
3.5
0.00
0.00
estimate
-0.00
46
263
178
1393
1.61
4.28
4.9
3.0
100.20
104.57
ug/l
0.12
165
1307
72
452
1.76
4.06
4.3
3.2
29.38
29.45
s
0.04
72
445
76
488
1.72
3.95
3.0
2.8
2.44
2.44
mmol/l
0.17
68
432
72
460
1.72
3.80
3.2
2.4
11.26
13.80
umol/l
2.02
67
427
57
340
1.82
3.80
2.1
1.9
—
—
—
0
0
11
25
4.51
3.65
2.1
2.8
0.36
0.96
index
2.25
11
25
225
1909
1.57
3.47
7.2
3.5
44.77
43.83
u/l
0.06
214
1827
30
148
2.13
3.43
2.1
1.7
—
—
—
0
0
53
320
1.78
3.39
2.2
2.0
—
—
—
0
0
44
251
1.87
3.37
4.8
4.5
2.82
10.02
ug/l
2.50
32
200
6
7
8.70
3.27
6.0
3.3
0.63
0.61
mmol/l
—
6
7
61
391
1.69
3.16
3.2
2.5
17.75
23.53
%
2.37
55
368
15
56
2.76
3.10
1.4
1.3
13313.00
12961.60
e6/l
—
10
40
6
8
7.61
3.06
2.2
2.4
130.05
63.91
ug/l
—
6
8
234
2037
1.52
2.91
3.4
3.4
—
—
—
0
0
302
2803
1.94
2.84
28.2
14.6
29.25
23.44
mg/l
2.36
272
2234
273
2465
1.63
2.83
23.8
13.7
87.84
86.30
ml/min/173m2
0.54
256
2223
10
28
3.65
2.80
6.2
3.5
96.50
104.29
%
—
10
28
11
34
3.31
2.75
2.2
3.1
22.45
15.08
index
0.51
11
25
18
79
2.35
2.73
1.4
1.3
333.08
301.58
ug/g
0.24
12
45
99
736
1.49
2.71
2.1
1.7
22.91
20.88
nmol/l
0.53
88
626
32
177
1.89
2.71
21.6
5.0
0.62
0.61
%
0.05
32
177
6
10
6.09
2.71
1.2
1.4
—
—
—
0
0
31
172
1.89
2.61
1.8
1.9
19.97
19.51
iu/l
0.03
26
134
20
95
2.18
2.54
1.6
1.2
—
—
—
0
0
20
95
2.18
2.54
1.6
1.2
—
—
—
0
0
20
96
2.15
2.48
1.7
1.8
—
—
—
0
0
307
2888
1.94
2.41
19.3
11.3
28.11
27.06
u/l
0.28
299
2807
47
305
1.63
2.33
17.6
7.4
6.27
7.93
mmol/l
1.86
47
299
243
2174
1.45
2.29
5.0
4.1
14.89
14.67
pmol/l
0.72
232
1987
18
86
2.16
2.27
2.2
2.0
—
—
—
0
0
14
62
2.31
2.10
1.2
1.2
—
—
—
0
0
14
62
2.31
2.10
1.2
1.2
—
—
—
0
0
18
89
2.08
2.10
1.6
1.7
—
—
—
0
0
99
770
1.41
2.08
5.3
3.6
0.00
0.00
estimate
0.50
41
266
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
15
69
2.23
2.08
6.8
6.4
0.28
0.34
iu/ml
—
9
40
5
10
5.06
2.08
1.4
1.3
—
—
—
0
0
5
10
5.06
2.08
1.4
1.4
—
—
—
0
0
12
50
2.45
2.05
2.1
1.6
—
—
—
0
0
66
480
1.47
1.98
1.8
1.7
402.04
28889333.33
pmol/l
0.50
56
405
16
79
2.08
1.88
2.4
1.9
—
—
—
0
0
17
86
2.03
1.88
2.0
1.6
257.88
188.77
u/ml
—
8
43
9
34
2.69
1.88
1.6
1.3
—
—
—
0
0
11
46
2.44
1.87
1.5
1.5
—
—
—
0
0
16
80
2.05
1.83
1.4
1.3
—
—
—
0
0
30
187
1.66
1.76
25.0
5.2
127.37
130.72
g/l
0.33
30
181
53
379
1.47
1.74
2.0
1.7
1234.77
1174.17
nmol/l
0.16
35
279
7
24
2.96
1.73
1.0
1.1
—
—
—
0
0
16
82
2.00
1.72
2.2
1.6
—
—
—
0
0
5
13
3.89
1.72
1.4
1.4
—
—
—
0
0
23
134
1.77
1.71
1.4
1.4
—
—
—
0
0
13
62
2.14
1.68
1.6
1.5
—
—
—
0
0
10
41
2.48
1.66
2.1
3.3
—
—
—
0
0
85
669
1.36
1.64
5.1
3.4
1.02
1.02
kg/l
1.05
57
434
94
752
1.35
1.63
3.0
3.6
1640.86
1026.32
ng/l
0.40
77
633
7
26
2.73
1.59
6.9
3.3
2.03
3.02
nmol/l
—
7
26
15
78
1.97
1.57
1.4
2.0
4.70
3.69
iu/l
—
5
33
132
1116
1.31
1.55
4.4
3.3
0.00
0.01
estimate
0.74
33
241
19
108
1.81
1.54
1.1
1.4
341.33
264.22
miu/ml
—
6
53
5
15
3.37
1.53
1.6
1.4
—
—
—
0
0
6
21
2.89
1.51
2.8
2.4
—
—
—
0
0
17
94
1.85
1.50
2.0
1.6
—
—
—
0
0
21
125
1.73
1.47
1.4
1.5
—
—
—
0
0
14
73
1.96
1.46
1.4
1.6
—
—
—
0
0
22
135
1.67
1.40
3.9
2.4
25255.70
5815.34
u/l
—
10
46
6
23
2.64
1.37
1.0
1.0
—
—
—
0
0
0
41
0.00
1.32
0.0
1.4
—
7.45
—
0
32
8
34
2.39
1.30
1.1
1.5
—
—
—
0
0
15
84
1.82
1.29
1.5
1.5
—
—
—
0
0
9
44
2.07
1.28
2.3
1.4
—
—
—
0
0
33
230
1.48
1.25
1.0
1.0
—
—
—
0
0
12
63
1.94
1.24
1.7
1.4
—
—
—
0
0
8
37
2.19
1.22
1.4
1.6
—
—
—
0
0
58
452
1.34
1.19
1.3
1.3
12.34
8.23
u/ml
0.29
21
160
11
57
1.96
1.18
1.5
1.2
—
—
—
0
0
5
20
2.52
1.15
1.4
1.2
—
—
—
0
0
13
73
1.81
1.12
1.3
2.1
—
—
—
0
0
271
2566
1.32
1.11
6.1
5.0
1.78
1.88
mu/l
0.90
260
2373
9
46
1.98
1.04
1.4
1.6
—
—
—
0
0
26
180
1.48
1.04
1.6
1.3
—
—
—
0
0
13
76
1.74
1.00
2.0
2.5
—
—
—
0
0
7
36
1.96
0.97
2.4
1.2
0.21
0.17
nmol/l
—
7
24
102
879
1.23
0.96
1.4
1.5
3.17
1.82
u/ml
0.37
30
219
6
28
2.16
0.92
1.0
1.0
—
—
—
0
0
129
1144
1.21
0.91
2.3
2.0
1.32
1.36
mmol/l
0.28
112
975
7
126
0.55
0.90
1.7
1.7
—
—
—
0
0
6
29
2.09
0.89
1.5
1.2
85.50
111.24
pmol/l
—
6
29
27
195
1.42
0.89
5.5
2.6
70.20
67.30
ml/min/173m2
—
10
91
10
56
1.81
0.88
1.4
1.8
—
—
—
0
0
71
599
1.24
0.81
3.9
4.4
22.27
22.22
%
0.01
32
259
16
106
1.54
0.80
1.5
1.1
0.94
0.91
g/l
0.14
16
106
60
499
1.25
0.78
1.3
1.3
55.08
26.30
iu/ml
0.43
14
147
25
185
1.38
0.74
15.5
3.4
1.24
1.23
mmol/l
0.61
19
156
48
392
1.26
0.73
1.4
1.5
—
—
—
0
0
5
25
2.01
0.73
2.0
2.1
—
—
—
0
0
5
25
2.01
0.73
1.4
1.2
—
—
—
0
0
7
40
1.77
0.71
2.4
1.3
0.50
0.48
nmol/l
—
7
35
7
42
1.68
0.69
1.9
1.5
—
—
—
0
0
7
42
1.68
0.69
1.1
1.1
—
—
—
0
0
7
43
1.64
0.67
1.0
1.1
—
—
—
0
0
7
43
1.64
0.67
1.0
1.1
—
—
—
0
0
252
2415
1.19
0.63
4.5
4.1
1.27
1.26
mmol/l
0.09
239
2243
107
964
1.16
0.61
4.2
3.6
24.43
35.99
ng/l
0.83
70
646
46
385
1.23
0.59
1.9
1.9
1.42
1.47
%
0.21
39
345
6
35
1.73
0.58
1.5
1.4
—
—
—
0
0
6
36
1.68
0.57
2.0
1.2
—
—
—
0
0
53
452
1.21
0.57
2.9
3.0
0.58
0.83
ug/l
1.91
33
280
75
661
1.17
0.56
4.0
3.2
328.63
344.20
umol/l
0.59
67
581
9
61
1.49
0.54
1.3
1.1
—
—
—
0
0
6
39
1.55
0.53
1.0
1.1
—
—
—
0
0
6
40
1.51
0.52
1.3
1.2
—
—
—
0
0
82
736
1.15
0.49
2.0
1.8
—
—
—
0
0
7
47
1.50
0.48
1.1
1.1
—
—
—
0
0
28
229
1.24
0.45
5.3
2.4
0.54
0.19
e6/l
0.45
28
216
7
51
1.38
0.44
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
2.0
1.5
—
—
—
0
0
5
31
1.62
0.43
2.0
1.5
—
—
—
0
0
5
31
1.62
0.43
1.0
2.4
9.00
11.45
mmol/l
—
5
31
5
32
1.57
0.42
2.0
1.4
—
—
—
0
0
5
32
1.57
0.42
2.8
1.4
—
—
—
0
0
5
32
1.57
0.42
2.8
1.4
—
—
—
0
0
5
32
1.57
0.42
2.8
1.4
—
—
—
0
0
5
33
1.52
0.41
1.0
1.0
2.76
3.76
kpa
—
5
28
5
33
1.52
0.41
1.0
1.0
7.18
6.61
kpa
—
5
28
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
5
34
1.48
0.40
1.4
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
0.20
—
0
18
266
2590
1.14
0.39
5.8
5.4
2.63
2.71
mmol/l
0.86
255
2431
17
214
0.78
0.39
1.5
1.5
—
—
—
0
0
5
36
1.39
0.38
1.4
1.2
—
—
—
0
0
5
36
1.39
0.38
1.4
1.2
—
—
—
0
0
16
125
1.29
0.37
1.2
1.3
—
—
—
0
0
6
42
1.44
0.35
1.8
1.4
—
—
—
0
0
6
43
1.40
0.35
1.3
1.2
—
—
—
0
0
84
775
1.11
0.34
5.3
5.3
1.91
2.03
ug/l
0.12
76
687
249
2428
1.11
0.30
6.6
6.0
38.15
38.80
mmol/mol
0.59
240
2291
10
75
1.34
0.30
1.4
1.2
—
1.00
—
0
5
14
111
1.27
0.30
2.0
1.6
16.92
9.58
u/ml
—
6
25
8
62
1.30
0.28
1.1
1.5
86.26
49.90
ug/l
—
8
62
89
835
1.09
0.26
4.0
2.9
0.00
0.00
estimate
0.50
33
230
262
2569
1.10
0.25
5.3
4.8
4.44
4.59
mmol/l
1.66
251
2410
29
255
1.15
0.25
4.0
3.0
—
—
—
0
0
9
76
1.19
0.25
1.2
1.2
—
52.76
—
0
9
7
91
0.76
0.23
1.4
2.1
225.71
228.13
pmol/l
—
7
85
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
42.54
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
260
2555
1.08
0.21
5.0
4.7
1.37
1.44
mmol/l
2.53
250
2389
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
6
49
1.23
0.20
2.2
1.8
—
—
—
0
0
86
817
1.07
0.19
4.2
4.2
2.38
10.00
mg/mmol
4.92
54
521
29
263
1.11
0.17
2.0
2.1
—
—
—
0
0
5
67
0.74
0.17
3.2
1.8
—
—
—
0
0
9
78
1.16
0.15
2.0
3.3
33.78
116.01
mg/l
—
9
66
9
78
1.16
0.15
2.0
3.3
26.86
28.33
mg/l
—
9
66
9
78
1.16
0.15
1.7
1.3
—
—
—
0
0
9
81
1.11
0.15
2.3
1.4
—
—
—
0
0
8
97
0.82
0.14
1.4
1.1
—
10.27
—
0
13
10
117
0.85
0.13
1.3
2.4
46.00
41.06
u/l
—
10
109
24
222
1.09
0.10
1.8
2.0
—
—
—
0
0
5
48
1.04
0.09
2.6
1.2
—
—
—
0
0
6
56
1.07
0.08
11.0
2.6
4.97
8.44
pmol/l
—
6
56
7
68
1.03
0.08
1.6
1.4
—
—
—
0
0
7
80
0.87
0.07
1.6
1.7
—
—
—
0
0
24
229
1.05
0.04
1.8
1.7
3.67
3.49
mmol/l
0.33
18
165
13
121
1.08
0.04
1.8
1.9
45.54
37.53
nmol/l
0.42
13
116
48
471
1.02
0.02
2.1
2.3
—
—
—
0
0
11
103
1.07
0.02
1.0
1.1
1.35
1.58
g/l
1.86
11
103
12
119
1.01
0.00
1.5
1.4
—
—
—
0
0
43
431
1.00
0.00
2.1
2.2
—
—
—
0
0
249
2487
1.00
0.00
5.2
4.7
5.78
5.87
mmol/l
0.63
233
2294
21
205
1.03
0.00
1.2
1.2
47.68
151.22
u/ml
—
9
75
25
255
0.98
0.00
5.8
6.6
—
—
—
0
0
13
126
1.03
0.00
1.2
1.1
6.42
5.23
—
5
15
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.0
—
32.33
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
25.98
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
88.50
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
1.7
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_INTESTINE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_INTESTINE | 1.262 [1.0, 1.59] | 0.047 |
| Birth year | 0.992 [0.98, 1.0] | 0.057 |
During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 1498 females with Q17_OTHER_CONGEN_MALFO_INTESTINE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_INTESTINE | 1.574 [1.26, 1.97] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 193 out of 1619 males with Q17_OTHER_CONGEN_MALFO_INTESTINE died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_INTESTINE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.398% |
| 5 | 0.63% | 2.107% |
| 10 | 1.673% | 5.054% |
| 15 | 3.275% | 9.363% |
| 20 | 5.698% | 15.628% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_INTESTINE – Other congenital malformations of intestine
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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