Other congenital malformations of digestive system

Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM2

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — Q45 Cause of death: ICD-10 — Q45 2 out of 7 registries used, show all original rules.	102
4. Check minimum number of events None	102
5. Include endpoints None	102
6. Filter based on genotype QC (FinnGen only)	88

Control definitions (FinnGen only)

Control exclude: Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM1

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: Q3[8-9]|Q4[0-5]
Name in latin: Aliae malformationes congenitae systematis digestorii

NAME	Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM2
CONTROL_EXCLUDE	Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM1
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	Q45
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	Q45
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other congenital malformations of digestive system based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	600	350	249
Only index persons	515	309	206
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	37.88	37.47	38.37
Only index persons	42.13	40.50	44.57

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	88	48	40
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	50.08	49.98	50.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
91: Matched controls
909

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

Q45.38

ICD-10 Finland

Other congenital malformations of pancreas and pancreatic duct

+∞

34.6

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

7.0

19.5

169

Q45.8

ICD-10 Finland

Other specified congenital malformations of digestive system

+∞

18.3

Q45.30

ICD-10 Finland

Ectopic pancreas

+∞

12.8

XJD02

NOMESCO Finland

Peroral endoscopic ultrasonography

34.1

9.7

K86.1

ICD-10 Finland

Other chronic pancreatitis

111.0

9.6

Q45.1

ICD-10 Finland

Annular pancreas

+∞

9.5

A09AA02

ATC

multienzymes (lipase, protease etc.); oral

16.2

9.0

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.8

8.9

133

Kela drug reimbursment

Severe chronic pancreatic insufficiency

22.7

8.7

JLB28

NOMESCO Finland

Endoscopic internal drainage of pancreatic duct

+∞

8.5

K86.8

ICD-10 Finland

Other specified diseases of pancreas

49.3

7.9

601

Kela drug reimbursment

Severe malabsorption of nutrients, mainly fats

49.3

7.9

K85.9

ICD-10 Finland

Acute pancreatitis, unspecified

20.5

7.8

Q45.0

ICD-10 Finland

Agenesis, aplasia and hypoplasia of pancreas

+∞

7.4

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

3.3

7.3

237

K85

ICD-10 Finland

Acute pancreatitis

32.9

7.3

A02BC01

ATC

omeprazole; systemic

3.4

6.9

142

JN3BD

NOMESCO Finland

Extensive abdominal CT

4.3

6.8

R10.1

ICD-10 Finland

Pain localized to upper abdomen

3.6

6.7

100

Q45.9

ICD-10 Finland

Congenital malformation of digestive system, unspecified

+∞

6.3

JAH00

NOMESCO Finland

Laparotomy

11.2

6.2

JL5BG

NOMESCO Finland

MRI examinaiton of bile and pancreas ducts with high intesity magnet

16.4

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018095) Leukocytes [#/volume] in Urine

307

3.14

6.55

4.9

4.0

71.08

55.96

e6/l

0.11

222

(40768797) Stomach Pathology biopsy report

108

3.30

5.91

1.7

1.2

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

118

3.14

5.58

15.0

7.2

104.28

103.69

mmol/l

0.27

118

(3042936) Bacteria identified in Isolate by Culture

112

3.00

4.97

2.0

2.8

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

14.97

4.65

4.7

1.6

18.57

32.00

umol/l

—

(3015736) pH of Urine

368

2.58

4.51

3.8

3.7

6.16

6.26

0.26

218

(3025941) Bacteria identified in Stool by Culture

3.59

4.45

1.3

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

3.70

4.41

1.3

1.1

—

(3002582) Erythrocytes [#/volume] in Urine

281

2.49

4.40

4.0

3.1

11.85

31.75

e6/l

0.85

218

(3018418) pH of Serum or Plasma

233

2.49

4.30

4.3

4.1

7.40

7.39

1.02

175

(3000991) Gas panel - Venous blood

3.04

4.13

8.1

9.0

—

(3030467) Casts [#/volume] in Urine by Automated count

237

2.43

4.11

3.6

3.1

0.33

0.43

e6/l

0.25

175

(3013826) Glucose [Moles/volume] in Serum or Plasma

462

2.42

3.57

7.7

5.9

6.88

6.53

mmol/l

0.59

432

(3048689) Calprotectin [Mass/mass] in Stool

104

2.62

3.52

2.3

116.46

127.49

ug/g

0.07

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

142

2.40

3.37

3.6

3.0

0.57

0.64

e6/l

0.12

(3023368) Bacteria identified in Blood by Culture

222

2.22

3.28

7.9

4.5

—

(3035350) Ketones [Presence] in Urine by Test strip

446

2.22

3.11

5.3

3.9

0.00

estimate

-0.00

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

126

2.35

3.02

3.8

3.1

2.27

2.22

e6/l

0.01

(3019977) pH of Arterial blood

2.53

3.00

8.2

13.2

7.42

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.77

2.98

1.6

1.4

—

(3009261) Glucose [Presence] in Urine by Test strip

453

2.15

2.89

5.3

4.0

0.00

estimate

-0.00

(3003458) Phosphate [Moles/volume] in Serum or Plasma

100

2.43

2.86

9.8

7.3

1.08

1.06

mmol/l

0.14

(3021601) Nitrite [Presence] in Urine by Test strip

445

2.12

2.83

5.4

3.9

0.00

estimate

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

469

2.11

2.72

12.6

10.7

4.24

4.11

e9/l

0.22

398

(3007853) Bacteria identified in Skin by Aerobe culture

105

2.30

2.56

1.8

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

329

1.97

2.56

2.2

2.0

78.61

97.32

pmol/l

2.26

162

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

113

2.25

2.52

1.4

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

368

1.96

2.51

4.0

2.9

—

estimate

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

176

2.05

2.46

4.9

2.5

—

(3019198) Lymphocytes [#/volume] in Blood

409

1.96

2.44

9.7

6.9

2.17

1.83

e9/l

1.23

361

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

109

2.20

2.34

1.4

1.9

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.48

2.32

8.7

8.3

1.10

1.35

mmol/l

0.54

(3026008) Bacteria identified in Urine by Culture

239

1.92

2.29

6.7

3.3

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

5.79

2.24

1.2

—

(3001604) Monocytes [#/volume] in Blood

398

1.87

2.20

9.8

6.8

0.65

0.57

e9/l

1.12

342

(3006315) Basophils [#/volume] in Blood

399

1.87

2.17

9.9

6.8

0.04

e9/l

0.31

342

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

143

2.03

2.17

1.8

1.9

—

(3044640) Blood type and Crossmatch panel - Blood

261

1.86

2.14

4.4

2.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.70

2.10

1.3

1.2

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

4.20

2.07

1.8

2.1

7.72

3.36

u/ml

—

(3032080) INR in Blood by Coagulation assay

341

1.78

1.94

14.9

11.4

1.19

1.18

inr

0.04

295

(3038177) Helicobacter pylori Ab [Presence] in Serum

4.34

1.84

1.4

1.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

4.34

1.84

1.4

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.20

1.83

1.1

1.2

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.41

1.82

6.1

3.8

25.05

24.16

mmol/l

0.39

(3018010) Neutrophils/Leukocytes in Blood

376

1.73

1.77

9.0

6.1

57.28

57.11

0.03

364

(3013115) Eosinophils [#/volume] in Blood

415

1.74

1.77

10.6

7.2

0.21

0.18

e9/l

0.60

357

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.82

1.77

1.9

2.1

—

(42870588) Differential panel, method unspecified - Blood

256

1.75

1.76

9.9

6.0

—

(3034770) Mitochondria Ab [Titer] in Serum

3.07

1.76

1.6

1.1

—

(3012544) pH of Venous blood

2.07

1.74

5.6

4.4

7.36

7.38

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.00

1.73

1.0

1.1

—

(40758558) Short blood count panel - Blood

241

1.73

1.68

7.6

7.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

199

1.75

1.63

1.2

1.4

2.78

2.32

g/l

0.49

118

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

166

1.79

1.60

1.7

1.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.23

1.57

12.1

9.6

26.17

25.73

mmol/l

0.24

(3000494) Fungus identified in Specimen by Culture

1.99

1.53

1.5

1.8

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.84

1.46

1.5

1.0

0.00

g/l

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.84

1.46

1.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

3.24

1.45

1.4

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

3.24

1.45

1.4

1.1

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.53

1.42

2.4

3.9

274.43

200.62

—

(3019150) Specific gravity of Urine by Refractometry

200

1.66

1.35

4.5

4.0

1.02

kg/l

0.46

135

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.16

1.31

1.7

1.2

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.87

1.30

1.6

1.1

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.72

1.23

1.0

1.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

196

1.62

1.22

2.4

2.0

2.40

1.29

mg/l

0.48

161

(3004789) Transferrin [Mass/volume] in Serum or Plasma

121

1.72

1.17

2.5

2.4

2.32

2.41

g/l

0.25

110

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.58

1.16

1.0

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.58

1.16

1.0

1.2

—

(3020891) Body temperature

2.09

1.15

8.4

5.5

36.99

36.97

°c

—

(36660697) Celiac disease serology panel - Serum

1.88

1.13

1.4

1.2

—

(3021589) Normoblasts [#/volume] in Blood

376

1.51

1.13

15.8

10.4

0.00

e9/l

0.50

302

(3012516) Albumin [Mass/volume] in Urine

245

1.54

1.11

4.0

3.3

33.68

50.70

mg/l

0.29

171

(42529406) Shigella sp [Presence] in Stool by Culture

2.46

1.10

1.0

1.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.46

1.10

1.2

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

247

1.52

1.07

4.7

4.0

8.51

8.24

mg/mmol

0.01

164

(3029937) Albumin [Presence] in Urine by Test strip

247

1.52

1.07

6.2

3.9

0.00

estimate

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.92

1.02

5.8

3.3

1.88

1.39

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.92

1.02

5.8

3.2

0.72

0.74

—

(3022948) Iron [Moles/volume] in Serum or Plasma

135

1.62

0.99

2.6

2.4

13.04

13.16

umol/l

0.02

125

(3003327) Ova and parasites identified in Stool by Light microscopy

2.22

0.93

1.0

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

112

1.63

0.93

1.6

1.5

—

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

692

1.59

0.84

38.3

20.0

331.58

333.04

g/l

0.89

692

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.76

0.82

1.6

1.5

—

(1002224) Polysomnography panel

1.73

0.81

1.3

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.63

0.80

1.5

1.7

—

(4024509) Urine culture

1.87

0.80

2.2

1.7

—

(40768793) Breast Pathology biopsy report

0.00

0.79

0.0

1.4

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.14

0.76

1.2

2.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.14

0.76

1.0

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

310

1.39

0.75

3.3

3.6

30.95

32.53

ng/l

0.04

211

(3022145) Colonoscopy Study observation

1.60

0.74

1.1

1.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.05

0.74

2.0

1.4

1.46

1.21

g/l

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

2.05

0.74

1.0

1.3

—

4.08

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.05

0.74

2.0

1.3

0.20

0.25

g/l

—

(1761868) Lipid panel - Serum or Plasma

328

0.71

0.72

2.8

3.0

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

1.97

0.71

1.2

1.3

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.90

0.69

1.4

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.69

0.64

1.4

2.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.59

0.61

1.4

1.8

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

169

1.40

0.60

4.1

3.8

25.68

21.39

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.52

0.59

2.5

2.8

436.69

393.49

nmol/l

0.23

(3003694) ABO and Rh group [Type] in Blood

238

1.32

0.53

1.3

1.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.56

0.49

1.1

—

(3019060) Gas panel - Arterial blood

1.49

0.48

6.3

14.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

176

1.33

0.47

1.7

2.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

195

1.31

0.47

8.7

6.4

—

(3016879) Cocaine [Presence] in Urine

1.59

0.43

1.6

1.7

—

(40768443) Skin Pathology biopsy report

1.54

0.42

1.4

1.2

—

(3045424) Erythrocytes [Presence] in Urine

1.54

0.42

2.4

2.0

—

0.00

estimate

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

106

1.38

0.42

2.0

2.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.41

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.41

0.0

1.6

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.41

0.0

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

143

1.32

0.40

1.2

1.6

—

(40761535) Cells panel - Urine sediment

1.36

0.39

4.2

3.4

—

(3028300) Cannabinoids [Presence] in Urine

1.41

0.39

2.0

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

1.41

0.39

2.0

1.6

—

(3022313) Gas panel - Capillary blood

1.41

0.39

7.8

5.7

—

(3027008) Opiates [Presence] in Urine

1.41

0.39

2.0

1.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.49

0.37

1.3

—

(3002256) Pathology report gross observation

100

1.35

0.36

1.7

1.2

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

138

1.28

0.33

1.5

1.4

3.07

6.74

u/ml

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.37

0.32

1.7

3.1

4.30

4.52

pmol/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.29

0.31

1.1

1.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.30

0.27

2.0

3.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

346

1.17

0.25

6.2

3.8

0.00

estimate

—

(3027944) Amphetamines [Presence] in Urine

1.37

0.24

2.0

1.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

116

1.24

0.23

2.1

2.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

154

1.21

0.23

1.5

1.3

55.48

24.68

iu/ml

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

558

1.16

0.23

3.3

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

228

0.84

0.22

3.1

3.4

1224.31

1097.00

ng/l

0.07

190

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

51.15

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.21

0.0

2.9

—

(40768804) Tissue Pathology biopsy report

320

1.15

0.21

2.1

2.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.2

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3001405) CD3+CD8+ (T8 suppressor) cells [#/volume] in Blood

0.00

0.21

0.0

2.3

—

624.50

—

(3011412) CD3 cells [#/volume] in Blood

0.00

0.21

0.0

2.3

—

1397.88

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

122

0.80

0.21

1.1

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

129

1.19

0.18

3.8

2.7

0.60

0.70

ug/l

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

0.72

0.17

1.8

1.4

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.71

0.17

1.6

3.1

2.40

5.41

ug/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

113

1.17

0.14

1.4

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

252

1.10

0.10

5.5

3.1

0.00

estimate

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.14

0.10

1.2

1.9

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.10

0.09

1.5

2.1

—

(40761536) Microorganisms panel - Urine sediment

0.81

0.08

11.8

3.2

—

(4035726) Immunohistochemistry procedure

1.03

0.08

1.4

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.08

0.07

12.0

8.4

—

(3017732) Neutrophils [#/volume] in Blood

102

0.98

0.00

2.0

4.1

3.62

4.51

e9/l

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

2.8

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

1.6

—

0.60

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.1

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(43534046) Estradiol (E2) [Moles/volume] in Serum or Plasma by High sensitivity method

0.00

-0.00

0.0

3.2

—

0.21

—

(3045414) Leukocytes [Presence] in Urine

1.00

-0.00

2.0

1.9

—

0.00

estimate

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.94

-0.00

1.7

1.9

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.4

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.6

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

2080.80

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.6

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

0.96

-0.00

8.4

4.7

-0.24

1.04

mmol/l

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

5.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.4

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

-0.00

0.0

1.1

—

(3022493) Free Hemoglobin [Mass/volume] in Plasma

0.00

-0.00

0.0

2.8

—

192.60

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.9

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

10.5

—

0.59

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

1.4

—

89.11

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

4.58

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.6

—

60.60

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

136.92

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(40761511) CBC panel - Blood by Automated count

823

1.08

-0.00

24.2

12.4

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

0.95

-0.00

1.4

1.3

—

(3000492) Spirometry study

0.93

-0.00

1.4

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.2

—

(3034426) Prothrombin time (PT)

0.00

-0.00

0.0

1.0

—

28.40

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.2

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

46.40

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.4

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

2.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM2 and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM2.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM2 – Other congenital malformations of digestive system

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other congenital malformations of digestive system

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints