No definition available.
Congenital malformations of pulmonary and tricuspid valves
Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
289 |
4. Check minimum number of eventsNone |
289 |
5. Include endpointsNone |
289 |
6. Filter based on genotype QC (FinnGen only) |
255 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q2
- Name in latin
- Malformationes congenitae valvae (trunci) pulmonalis et valvae tricuspidalis
Similar endpoints
↥List of similar endpoints to
Congenital malformations of pulmonary and tricuspid valves
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations of the circulatory system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly, including avohilmo
- Congenital malformations, deformations and chromosomal abnormalities
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3353 | 1847 | 1493 |
| Only index persons | 2303 | 1282 | 1021 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 1.11 | 1.00 | 0.99 |
| Only index persons | 6.33 | 6.78 | 5.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 255 | 150 | 105 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 11.03 | 15.26 | 5.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 280
- Matched controls
- 2800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
204.0
170
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
54.3
189.6
116
36
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
101.6
187.5
99
15
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
23.1
158.5
151
135
201
Kela drug reimbursment
Chronic cardiac insufficiency
53.5
126.9
75
19
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
15.8
126.5
179
282
XF404
NOMESCO Finland
Ambulatory ECG
23.0
122.6
102
68
XF400
NOMESCO Finland
ECG with 12 standard connections
13.7
110.2
147
209
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
58.5
104.5
60
13
XF402
NOMESCO Finland
ECG with work load test
21.4
101.8
85
56
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
48.5
96.8
58
15
B01AA03
ATC
warfarin; systemic
16.5
87.4
84
71
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
14.3
85.3
91
91
C03DA01
ATC
spironolactone; oral
16.2
84.7
82
70
C03CA01
ATC
furosemide; systemic
10.6
77.4
109
159
FM2CE, ,
NOMESCO Finland
18.0
76.9
68
49
TPH07
NOMESCO Finland
Cathetrisation of artery
11.7
75.2
93
114
C01AA05
ATC
digoxin; systemic
31.2
69.4
47
18
ZXE20
NOMESCO Finland
More than three and less than five hours
8.4
58.9
97
166
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.8
58.8
108
208
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
57.3
53
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
23.8
55.0
41
20
Q22.5
ICD-10 Finland
Ebstein anomaly
+∞
53.9
50
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.5
53.4
184
634
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
49.5
46
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
47.2
44
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
10.1
46.7
59
72
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
21.6
46.5
36
19
31
HP
Congenital heart failure surgery
+∞
46.1
43
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
501.7
44.5
43
*
ZXD10
NOMESCO Finland
Scheduled procedure
5.5
44.4
172
629
Z2221
NOMESCO Finland
Medical doctor
5.4
44.3
151
497
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
43.9
41
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
9.0
43.8
61
84
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
41.7
39
*
61
HP
Catheterization and pressure measurement of the left side of the heart
460.5
41.2
40
*
WX408
NOMESCO Finland
General anesthesy, balanced
5.1
40.9
140
457
TFP20
NOMESCO Finland
Cardiodefibrillation
15.6
40.7
37
27
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
39.5
37
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
119.6
38.9
41
*
XF600
NOMESCO Finland
Bloodpressure measurement
6.9
38.3
69
126
ZXE10
NOMESCO Finland
More than one and less than three hours
4.7
36.3
146
531
62
HP
Catheterization and pressure measurement of the right side of the heart
394.0
35.8
35
*
WX892
NOMESCO Finland
Monitored bed care
6.9
32.1
56
98
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
+∞
31.9
30
*
R4110
NOMESCO Finland
Physiotherapy
4.2
31.1
131
482
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
173.5
30.3
31
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
6.9
29.0
50
86
WX882
NOMESCO Finland
High dependency care
6.1
29.0
57
112
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
5.9
28.7
59
121
Q20.48
ICD-10 Finland
Single ventricle
+∞
28.6
27
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.2
28.5
110
376
Z98.8
ICD-10 Finland
Other specified postsurgical states
111.6
28.3
30
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
42.7
27.8
34
9
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
66.8
26.5
30
5
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
7.2
25.6
41
65
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
25.4
24
*
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
23.2
22
*
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
130.7
23.0
24
*
WX872
NOMESCO Finland
Intensive care
20.2
22.8
34
19
207
Kela drug reimbursment
Chronic arrhythmias
6.2
22.2
41
75
Q22.2
ICD-10 Finland
Congenital pulmonary valve insufficiency
+∞
22.2
21
*
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
22.2
21
*
XFE00
NOMESCO Finland
Epicardial ultrasonography
42.4
22.2
27
7
Z3231
NOMESCO Finland
Registered nurse
3.3
21.5
139
644
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
+∞
21.1
20
*
XF622
NOMESCO Finland
Measurement of minute volume of heart
226.1
20.9
21
*
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
+∞
20.0
19
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
20.0
19
*
74663
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae pulmonalis
+∞
20.0
19
*
ZXD05
NOMESCO Finland
Urgent procedure
3.2
19.7
113
483
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
+∞
19.0
18
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
19.0
18
*
Q22.41
ICD-10 Finland
Tricuspid atresia
+∞
19.0
18
*
ZXE00
NOMESCO Finland
One hour or less
3.1
18.9
150
767
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
17.9
17
*
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
+∞
17.9
17
*
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
17.9
17
*
Q87.14
ICD-10 Finland
Noonan's syndrome
191.6
17.7
18
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.4
17.4
78
284
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
8.1
17.2
24
32
I44.2
ICD-10 Finland
Atrioventricular block, complete
27.7
17.2
23
9
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
37.6
16.9
21
6
C01BD01
ATC
amiodarone; systemic
26.4
16.3
22
9
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.4
16.1
72
261
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
15.8
15
*
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
+∞
15.8
15
*
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
15.8
15
*
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
+∞
15.8
15
*
G04BE03
ATC
sildenafil; oral
47.8
15.2
18
*
Z3226
NOMESCO Finland
Physiotherapist
3.0
15.1
90
384
ZXE40
NOMESCO Finland
More than seven and less than nine hours
11.8
14.9
27
25
Q21.32
ICD-10 Finland
Pulmonary atresia with Fallot ventricular septal defect
+∞
14.7
14
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
14.7
14
*
WX402
NOMESCO Finland
General anaesthesia
2.8
14.3
98
449
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
13.0
13.9
24
20
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.9
13.7
45
132
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
+∞
13.6
13
*
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
+∞
13.6
13
*
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
+∞
13.6
13
*
Q22.40
ICD-10 Finland
Congenital tricuspid stenosis
+∞
13.6
13
*
ZX120
NOMESCO Finland
Intravenous
3.9
13.2
43
125
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
52.6
13.0
15
*
C07AB07
ATC
bisoprolol; oral
2.7
12.9
95
448
B01AB05
ATC
enoxaparin; parenteral
3.0
12.9
68
269
C07AA07
ATC
sotalol; systemic
16.5
12.8
20
13
XF620
NOMESCO Finland
Examination of circulation with color method
73.3
12.7
14
*
1EA01, ,
NOMESCO Finland
+∞
12.6
12
*
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
12.6
12
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
12.6
12
*
Q22.3
ICD-10 Finland
Other congenital malformations of pulmonary valve
+∞
12.6
12
*
602
Kela drug reimbursment
Children's severe malnutrition
5.9
12.3
23
42
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
15.6
12.0
19
13
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
+∞
11.5
11
*
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
+∞
11.5
11
*
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
+∞
11.5
11
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
11.5
11
*
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
11.5
11
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
124.9
11.5
12
*
7AX01, ,
NOMESCO Finland
36.7
11.4
14
*
FM1BD
NOMESCO Finland
Extensive CT of heart
62.4
10.7
12
*
Q23.11
ICD-10 Finland
Bicuspid aortic valve
62.4
10.7
12
*
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
15.0
10.6
17
12
WX002
NOMESCO Finland
Sedation and analgesia
3.0
10.5
53
203
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
10.5
10
*
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
+∞
10.5
10
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
+∞
10.5
10
*
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
+∞
10.5
10
*
Q22.6
ICD-10 Finland
Hypoplastic right heart syndrome
+∞
10.5
10
*
74642
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium secundum
+∞
10.5
10
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.3
10.3
28
71
RS224, ,
NOMESCO Finland
13.8
10.3
17
13
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
10.3
76
355
R07.4
ICD-10 Finland
Chest pain, unspecified
2.6
10.0
71
325
I50.9
ICD-10 Finland
Heart failure, unspecified
5.2
10.0
21
43
ZX199
NOMESCO Finland
Other rote
15.8
9.6
15
10
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.3
9.5
102
561
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
103.4
9.5
10
*
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
103.4
9.5
10
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
9.4
9
*
AEX
HP
Other pulmonary or pulmonary artery valve procedure
+∞
9.4
9
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
+∞
9.4
9
*
Q21.21
ICD-10 Finland
Atrioventricular duct
+∞
9.4
9
*
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
9.4
9
*
FGB10
NOMESCO Finland
Repair of Ebstein's anomaly with mobilisation and ventricular plication
+∞
9.4
9
*
7461A
ICD-9 Finland
Other congenital anomalies of heart, Tricuspid atresia and stenosis, congenital[VITIUM VALVULAE TRICUSPIDALIS CONGENITUM CUM ATRESI]
+∞
9.4
9
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
9.4
9
*
Q21.3
ICD-10 Finland
Tetralogy of Fallot
+∞
9.4
9
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
9.4
9
*
WX704
NOMESCO Finland
Intubation
4.0
9.4
28
76
EBA15
NOMESCO Finland
Extraction of multiple teeth
5.3
9.2
19
38
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
5.1
9.2
20
42
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
9.1
49
194
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
19.4
9.0
13
7
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
25.0
9.0
12
5
Z2446
NOMESCO Finland
Social worker
2.7
8.7
53
223
I49.5
ICD-10 Finland
Sick sinus syndrome
12.1
8.7
15
13
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
4.7
8.5
20
45
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
92.7
8.5
9
*
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
+∞
8.4
8
*
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
+∞
8.4
8
*
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
+∞
8.4
8
*
7460B
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITUM CUM ATRESIA]
+∞
8.4
8
*
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
+∞
8.4
8
*
74734
ICD-8 Finland
Other congenital anomalies of circulatory system, Stenosis, hypoplasia sive aplasia arteriae pulmonalis
+∞
8.4
8
*
74654
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae tricuspidalis (morbus Ebstein incluso)
+∞
8.4
8
*
I47.1
ICD-10 Finland
Supraventricular tachycardia
4.6
8.3
20
46
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
7.3
7.9
18
26
I47.2
ICD-10 Finland
Ventricular tachycardia
11.3
7.9
14
13
K84
ICPC
Heart disease other
11.3
7.9
14
13
WZC30
NOMESCO Finland
Teaching
2.6
7.8
48
203
I50.1
ICD-10 Finland
Left ventricular failure
15.6
7.8
12
8
XQ903
NOMESCO Finland
Production of other scan or drawing
46.3
7.8
9
*
Z94.1
ICD-10 Finland
Heart transplant status
19.0
7.7
11
6
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
7.5
68
344
I48.4
ICD-10 Finland
Atypical atrial flutter
82.2
7.5
8
*
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
82.2
7.5
8
*
Q22.8
ICD-10 Finland
Other congenital malformations of tricuspid valve
+∞
7.3
7
*
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
+∞
7.3
7
*
Q24.0
ICD-10 Finland
Dextrocardia
+∞
7.3
7
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
+∞
7.3
7
*
FHE30
NOMESCO Finland
Repair of tetralogy of Fallot with transannular patch
+∞
7.3
7
*
7452A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[TETRALOGIA FALLOT]
+∞
7.3
7
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
7.3
7
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.1
7.3
20
51
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
16.3
7.3
11
7
C09AA02
ATC
enalapril; systemic
3.1
7.3
31
107
XX3BT
NOMESCO Finland
Other labeling with X-ray guidance
8.3
7.2
15
19
I44.1
ICD-10 Finland
Atrioventricular block, second degree
30.9
7.2
9
*
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
12.5
7.1
12
10
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.0
7.0
32
115
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.1
7.0
30
104
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
7.0
58
282
B34.9
ICD-10 Finland
Viral infection, unspecified
3.3
6.9
27
88
ZX108
NOMESCO Finland
Inhalation
14.2
6.9
11
8
I50.0
ICD-10 Finland
Congestive heart failure
7.5
6.8
15
21
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.5
6.7
24
74
1CX08, ,
NOMESCO Finland
71.4
6.5
7
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
71.4
6.5
7
*
FPJ04
NOMESCO Finland
Revision of pacemaker generator with atrial and ventricular electrodes
71.4
6.5
7
*
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
+∞
6.3
6
*
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
6.3
6
*
FGE10
NOMESCO Finland
Replacement of tricuspid valve using biological prosthesis
+∞
6.3
6
*
5239
FHL
Other measure in this category
+∞
6.3
6
*
Q21.31
ICD-10 Finland
Tetralogy of Fallot and double outlet right ventricle
+∞
6.3
6
*
7462A
ICD-9 Finland
Other congenital anomalies of heart, Ebstein's anomaly[ANOMALIA EBSTEIN]
+∞
6.3
6
*
FBJ00
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery
+∞
6.3
6
*
FJD96
NOMESCO Finland
Other operation on right ventricle outlet for congenital or acquired obstruction
+∞
6.3
6
*
I27.0
ICD-10 Finland
Primary pulmonary hypertension
+∞
6.3
6
*
FK1AC
NOMESCO Finland
Right cardioangiography
+∞
6.3
6
*
5253
FHL
Cardiac lung machine
+∞
6.3
6
*
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
6.3
6
*
Q22.4
ICD-10 Finland
Congenital tricuspid stenosis
+∞
6.3
6
*
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
6.3
6
*
AD1
HP
TVP
+∞
6.3
6
*
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
6.3
6
*
5504
FHL
Subclavian pulmonary anastomosis (Blalock)
+∞
6.3
6
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
6.3
6
*
FPF00
NOMESCO Finland
Implantation of epicardial pacemaker with ventricular electrode
+∞
6.3
6
*
R62.0
ICD-10 Finland
Delayed milestone
3.3
6.2
24
78
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
3.3
6.2
24
78
XF640, ,
NOMESCO Finland
8.9
6.1
12
14
H01AC01
ATC
somatropin; parenteral
3.9
6.0
18
49
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
123
73
29.27
158.41
6.6
5.3
155.06
129.17
ng/l
0.23
117
65
196
334
17.23
131.44
10.6
4.5
696.94
735.76
ng/l
0.11
190
269
128
315
6.64
54.00
9.2
6.3
32.16
30.05
s
1.65
128
310
117
310
5.77
44.36
7.5
3.1
1814.81
521.56
ng/l
1.54
100
170
43
36
13.93
43.83
3.8
7.8
79.07
101.69
%
3.28
43
36
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
44
43
11.95
40.60
23.7
19.9
0.29
0.40
iu/ml
0.81
30
26
141
492
4.76
37.16
3.9
3.1
—
—
—
0
0
56
91
7.44
34.52
28.1
16.8
24.36
24.29
mmol/l
0.06
56
91
147
558
4.44
34.01
12.4
7.2
73.63
90.66
%
13.32
147
549
55
100
6.60
30.31
2.0
2.8
30.76
6.97
ug/l
2.64
49
88
53
107
5.88
26.08
29.6
14.9
0.64
0.69
%
0.45
53
107
65
159
5.02
25.77
25.3
14.6
0.32
0.77
mmol/l
0.44
59
137
53
110
5.71
25.29
29.6
14.6
1.10
1.33
%
1.54
53
110
80
241
4.25
24.25
18.9
12.4
106.28
104.62
mmol/l
2.54
80
241
35
52
7.55
23.08
1.5
1.5
—
—
—
0
0
173
935
3.22
20.15
4.4
3.2
—
—
estimate
—
0
0
109
456
3.28
19.66
5.3
3.6
1.42
1.08
mg/l
0.64
86
338
18
5
38.29
14.62
2.4
14.0
5.02
4.54
kpa
—
18
5
91
411
2.80
13.57
25.1
17.4
25.07
24.70
mmol/l
0.70
91
411
162
996
2.49
12.46
12.0
7.6
17.88
18.82
umol/l
0.17
156
941
26
54
5.21
12.17
5.5
23.5
71.29
66.90
%
0.63
26
54
117
642
2.41
11.31
3.6
3.3
2.99
2.53
mg/l
0.70
108
563
88
428
2.54
11.02
18.3
11.8
1.30
1.27
mmol/l
0.50
88
401
104
551
2.41
10.78
4.4
3.3
42.87
20.10
ng/l
0.77
66
286
28
70
4.33
10.50
2.9
1.6
1.02
1.27
g/l
0.76
23
64
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
20
22
9.70
10.20
1.5
2.1
127.15
98.68
%
1.01
20
22
69
312
2.61
9.94
2.8
2.1
—
—
—
0
0
18
18
10.60
9.67
1.5
2.2
149.28
111.61
%
1.49
18
18
33
105
3.43
8.83
6.4
15.4
0.74
0.58
%
1.58
33
105
55
236
2.66
8.73
2.6
2.0
—
—
—
0
0
54
232
2.64
8.54
2.7
2.1
—
—
—
0
0
29
87
3.60
8.47
1.9
2.1
—
—
—
0
0
271
2403
4.97
8.32
27.0
13.9
65.98
66.09
umol/l
0.02
271
2370
183
1324
2.10
7.93
16.9
7.5
6.04
6.23
mmol/l
0.81
178
1231
29
91
3.44
7.92
1.9
2.4
—
—
—
0
0
263
2239
3.88
7.73
34.4
15.0
3.98
3.94
mmol/l
1.98
263
2181
263
2241
3.86
7.68
34.0
15.0
139.34
139.57
mmol/l
1.14
263
2190
11
6
19.00
7.66
1.6
1.8
—
—
—
0
0
70
360
2.26
7.42
17.2
10.6
2.00
0.71
mmol/l
4.07
58
271
71
372
2.22
7.17
17.8
10.5
5.15
5.03
kpa
1.01
71
358
21
57
3.90
7.05
1.7
2.0
—
—
—
0
0
160
1135
1.96
6.95
22.1
11.8
1.21
1.23
mmol/l
3.18
149
1025
73
407
2.07
6.21
10.2
11.3
1.27
1.02
mmol/l
0.36
67
334
12
14
8.90
6.12
1.3
1.1
89.33
99.79
%
0.44
12
14
17
44
4.05
6.08
1.2
1.1
—
—
—
0
0
21
64
3.47
5.99
2.7
2.2
4.29
4.54
index
0.05
14
35
20
63
3.34
5.43
1.9
2.0
—
—
—
0
0
54
286
2.10
5.21
6.5
6.5
8.35
7.49
umol/l
0.20
49
234
255
2232
2.60
5.20
34.8
17.9
13.63
13.25
%
3.73
255
2211
167
1275
1.77
5.06
4.9
3.6
74.74
68.53
ug/l
0.31
159
1220
20
66
3.19
5.05
1.4
1.5
—
—
—
0
0
16
46
3.63
4.97
1.4
1.2
1.36
1.83
u/ml
0.60
11
24
212
1748
1.88
4.85
19.6
10.3
98.47
96.39
ml/min/173m2
0.53
183
1477
9
10
9.25
4.82
1.2
1.9
12.22
10.92
umol/l
—
9
10
16
48
3.47
4.68
1.3
1.2
3.67
2.83
u/ml
—
9
23
189
1518
1.75
4.58
12.6
12.5
3.89
3.71
e9/l
0.52
170
1287
16
50
3.33
4.41
2.0
2.0
—
—
—
0
0
19
67
2.97
4.32
1.5
1.7
—
—
—
0
0
28
123
2.42
4.19
2.7
2.1
112.15
106.81
au/ml
0.09
13
53
15
53
2.93
3.41
2.1
5.5
—
—
—
0
0
26
123
2.23
3.32
2.8
2.1
—
—
—
0
0
24
111
2.27
3.23
2.1
1.7
—
—
—
0
0
13
44
3.05
3.18
1.5
1.5
—
—
—
0
0
261
2401
2.28
3.15
26.2
13.4
24.97
21.76
mg/l
1.02
229
1821
10
26
3.95
3.01
2.6
1.7
1.40
0.69
index
—
10
26
68
958
0.62
3.01
1.6
1.8
0.72
2.66
u/ml
2.51
20
190
12
38
3.25
2.89
1.6
1.4
—
—
—
0
0
16
65
2.55
2.84
12.3
15.5
—
2479.40
—
0
10
27
139
2.04
2.81
1.4
2.0
—
—
—
0
0
13
49
2.73
2.66
1.2
1.4
—
—
—
0
0
23
114
2.11
2.65
4.3
2.9
67.00
75.26
ml/min/173m2
—
5
46
10
30
3.42
2.63
1.6
1.5
—
—
—
0
0
8
20
4.09
2.58
1.4
1.6
—
—
—
0
0
9
27
3.41
2.41
1.9
1.2
—
—
—
0
0
9
28
3.29
2.33
1.2
1.3
—
—
—
0
0
15
67
2.31
2.22
3.2
4.3
37.07
38.97
umol/l
0.14
15
62
13
55
2.43
2.15
1.9
5.3
12.62
9.80
%
0.31
13
55
104
818
1.43
2.15
4.8
4.4
—
—
—
0
0
6
15
4.06
2.05
10.3
10.2
—
—
—
0
0
12
51
2.41
1.98
1.9
5.2
13.08
26.71
%
3.19
12
51
5
13
3.89
1.72
2.0
1.3
—
—
—
0
0
31
199
1.63
1.65
1.6
1.6
1067.68
1217.81
nmol/l
0.48
25
151
5
14
3.62
1.62
1.0
1.2
—
—
—
0
0
59
440
1.43
1.59
2.8
4.0
4.25
2.28
e6/l
0.58
36
225
13
64
2.08
1.56
1.5
1.4
213.88
309.76
ug/g
—
8
33
23
139
1.71
1.54
2.8
3.2
0.09
0.18
e6/l
0.96
23
133
23
139
1.71
1.54
3.0
2.9
—
—
—
0
0
6
21
2.90
1.51
1.2
1.8
—
—
—
0
0
6
21
2.90
1.51
1.2
1.8
—
—
—
0
0
6
21
2.90
1.51
1.2
1.8
—
—
—
0
0
13
65
2.05
1.51
2.2
2.0
—
—
—
0
0
87
700
1.35
1.50
4.6
4.2
0.48
0.29
e6/l
0.53
70
498
9
39
2.35
1.44
7.4
6.5
7.28
7.47
pmol/l
—
9
39
13
67
1.99
1.40
3.2
1.9
—
73.67
—
0
6
6
23
2.64
1.37
1.0
1.2
—
—
—
0
0
5
17
2.97
1.36
7.0
8.2
—
—
—
0
0
5
17
2.97
1.36
1.0
1.6
—
—
—
0
0
0
39
0.00
1.35
0.0
1.4
—
115.00
—
0
6
23
145
1.64
1.34
3.0
2.0
165.53
157.92
u/ml
0.06
17
66
40
287
1.46
1.33
1.5
1.7
495.14
26070515.16
pmol/l
0.50
35
257
14
76
1.89
1.32
1.2
1.2
—
—
—
0
0
33
229
1.50
1.29
2.2
2.5
35.18
32.44
u/l
0.17
28
183
7
33
2.15
1.06
2.4
1.4
8438.86
5778.48
e6/l
—
7
25
200
2133
0.78
1.05
4.4
3.9
—
—
—
0
0
11
61
1.84
1.00
1.3
1.7
—
—
—
0
0
11
61
1.84
1.00
2.4
1.9
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
30
0.00
0.98
0.0
1.4
—
—
—
0
0
0
32
0.00
0.95
0.0
1.4
—
—
—
0
0
52
638
0.77
0.91
1.9
2.5
—
—
—
0
0
8
43
1.89
0.88
1.8
1.8
—
—
—
0
0
8
44
1.84
0.86
2.4
4.2
19.40
7.43
u/ml
—
8
44
25
336
0.72
0.81
1.6
2.1
—
—
—
0
0
8
47
1.72
0.81
3.4
2.2
—
—
—
0
0
46
565
0.78
0.81
3.8
3.1
1.02
1.02
kg/l
0.03
30
354
49
597
0.78
0.81
1.9
2.4
—
—
—
0
0
0
26
0.00
0.79
0.0
1.5
—
—
—
0
0
55
456
1.26
0.76
3.2
3.8
1.01
0.73
e6/l
0.44
33
241
9
55
1.66
0.74
1.7
1.7
—
—
—
0
0
5
25
2.02
0.73
1.6
1.0
—
—
—
0
0
199
1876
1.21
0.73
5.3
4.2
15.13
14.54
pmol/l
2.72
186
1743
11
68
1.64
0.73
1.1
2.3
—
—
—
0
0
15
213
0.69
0.68
4.5
2.0
14.69
13.51
iu/l
0.06
15
150
5
28
1.80
0.66
4.4
6.3
—
—
—
0
0
186
1751
1.19
0.65
4.7
4.8
35.84
37.33
mmol/mol
1.84
177
1660
53
448
1.23
0.62
1.6
1.5
18.27
21.01
nmol/l
0.85
47
389
9
141
0.63
0.62
1.0
1.4
—
—
—
0
0
224
2149
1.21
0.61
6.1
4.9
2.13
1.88
mu/l
1.90
215
2030
0
20
0.00
0.60
0.0
1.8
—
13.16
—
0
20
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
211.88
—
0
20
11
73
1.53
0.57
1.1
2.1
—
—
—
0
0
11
74
1.51
0.54
1.5
1.5
—
—
—
0
0
11
74
1.51
0.54
1.5
1.5
—
—
—
0
0
9
134
0.66
0.53
1.4
2.0
—
—
—
0
0
16
213
0.74
0.52
1.1
1.3
26.33
3.02
u/ml
1.37
11
156
22
276
0.78
0.48
1.1
1.1
—
—
—
0
0
12
165
0.72
0.48
1.3
1.5
—
—
—
0
0
36
302
1.22
0.47
2.3
2.2
2.42
2.43
mmol/l
0.40
31
264
12
164
0.72
0.46
1.2
1.8
—
—
—
0
0
30
359
0.82
0.45
1.2
1.3
3.74
7.25
u/ml
—
9
133
78
857
0.88
0.43
3.9
3.2
0.00
0.02
estimate
0.50
24
185
13
96
1.37
0.42
13.2
6.0
42.37
54.05
%
0.93
13
96
198
1904
1.14
0.41
4.5
4.4
2.61
2.72
mmol/l
0.93
185
1791
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
5.4
—
82.60
—
0
15
0
15
0.00
0.41
0.0
1.1
—
7.85
—
0
6
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
197
1903
1.12
0.35
4.3
4.1
4.26
4.55
mmol/l
3.40
188
1797
192
1853
1.12
0.34
3.2
3.6
5.47
5.60
mmol/l
0.98
183
1712
6
87
0.68
0.33
1.7
1.8
1.95
0.53
nmol/l
—
6
76
6
87
0.68
0.33
1.0
1.0
2.70
3.12
kpa
—
6
76
6
88
0.67
0.33
1.0
1.0
7.73
7.34
kpa
—
6
77
14
175
0.79
0.32
2.1
1.2
—
—
—
0
0
13
102
1.29
0.30
1.5
1.3
—
—
—
0
0
10
130
0.76
0.30
1.0
1.1
11.52
11.05
u/ml
—
5
78
39
434
0.88
0.27
4.3
4.4
13.08
11.80
mg/mmol
0.07
28
295
182
1765
1.09
0.25
3.9
3.5
1.20
1.21
mmol/l
0.06
170
1649
26
228
1.15
0.23
1.3
1.3
106.30
142.65
u/ml
—
10
75
5
40
1.25
0.22
2.0
1.8
—
—
—
0
0
125
1199
1.08
0.22
3.9
3.6
0.00
7.01
estimate
0.50
30
215
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
5.9
—
797.10
—
0
10
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
35
385
0.90
0.20
1.6
2.3
—
—
—
0
0
6
48
1.26
0.20
2.0
1.4
12.40
14.56
u/l
—
6
39
0
14
0.00
0.20
0.0
3.8
—
25.71
—
0
14
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
124
1193
1.07
0.20
3.9
3.6
0.00
0.00
estimate
-0.00
30
220
16
186
0.85
0.20
3.1
3.9
33.80
32.08
%
—
10
130
6
51
1.18
0.19
1.5
1.2
—
—
—
0
0
41
377
1.10
0.19
1.4
1.5
—
—
—
0
0
63
593
1.08
0.18
4.4
3.6
0.00
0.00
estimate
0.50
28
205
85
810
1.07
0.18
2.0
2.0
1.24
1.36
mmol/l
0.78
79
719
5
68
0.73
0.17
1.0
1.3
—
—
—
0
0
6
76
0.78
0.16
1.0
1.1
—
—
—
0
0
6
79
0.75
0.15
1.0
1.1
—
—
—
0
0
14
160
0.87
0.14
1.4
1.3
—
—
—
0
0
124
1204
1.05
0.14
3.9
3.7
0.00
0.00
estimate
-0.00
29
208
12
103
1.17
0.14
1.6
1.4
—
—
—
0
0
8
98
0.81
0.14
2.3
1.7
—
—
—
0
0
192
1890
1.05
0.12
4.2
4.0
1.34
1.42
mmol/l
2.26
181
1774
70
726
0.95
0.10
1.9
1.8
85.45
97.67
pmol/l
1.63
40
370
16
146
1.10
0.08
1.7
1.6
—
—
—
0
0
15
163
0.92
0.07
1.4
1.2
—
31.83
—
0
7
14
152
0.92
0.06
6.1
5.3
—
—
—
0
0
96
979
0.97
0.06
1.9
2.0
—
—
—
0
0
11
121
0.91
0.06
1.5
1.7
—
—
—
0
0
109
1078
1.02
0.03
4.4
3.3
72.13
71.08
nmol/l
0.17
104
1005
13
122
1.07
0.02
1.5
1.5
—
—
—
0
0
17
177
0.96
0.01
2.8
3.7
28.62
23.32
%
—
5
68
38
382
0.99
0.00
1.3
1.3
15.66
29.41
iu/ml
—
10
95
13
127
1.02
0.00
1.5
1.5
1.00
1.24
ratio
—
6
81
13
127
1.02
0.00
1.5
1.5
0.97
0.95
ratio
—
6
81
13
127
1.02
0.00
1.5
1.5
0.96
1.15
ratio
—
6
81
21
215
0.97
0.00
1.7
2.5
21317.17
6451.71
u/l
—
6
79
14
136
1.03
0.00
2.1
2.7
0.41
0.82
ug/l
—
6
69
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
70.25
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
1.48
—
0
6
5
50
1.00
-0.00
3.2
2.4
0.18
0.12
nmol/l
—
5
39
9
92
0.98
-0.00
1.4
1.5
76.58
58.47
ug/l
—
9
92
9
95
0.95
-0.00
1.0
1.1
0.79
0.88
g/l
—
9
95
8
80
1.00
-0.00
1.6
2.4
38.88
41.21
u/l
—
8
74
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
6.8
—
3.58
—
0
9
0
7
0.00
-0.00
0.0
4.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
58
0.86
-0.00
1.2
1.5
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.6
—
—
—
0
0
9
93
0.97
-0.00
1.0
1.1
1.29
1.51
g/l
—
9
93
0
6
0.00
-0.00
0.0
7.5
—
—
—
0
0
64
640
1.00
-0.00
3.3
2.9
0.00
0.02
estimate
0.68
24
179
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES | 3.441 [2.43, 4.87] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.268 |
During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 1682 females with Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES | 4.147 [3.13, 5.5] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 1349 males with Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.287% | 0.541% |
| 5 | 2.239% | 5.113% |
| 10 | 5.248% | 12.434% |
| 15 | 9.974% | 22.743% |
| 20 | 16.615% | 36.333% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES – Congenital malformations of pulmonary and tricuspid valves
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data