Congenital mitral valve regurgitation

Q17_CONGENITAL_MITRAL_VALVE_REGURGITATION

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q23.3
  • Hospital discharge: ICD-9 7466A
  • Cause of death: ICD-10 Q23.3
  • Cause of death: ICD-9 7466A

2 out of 7 registries used, show all original rules.

65

4. Check minimum number of events

None

65

5. Include endpoints

None

65

6. Filter based on genotype QC (FinnGen only)

63

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 63 35 28
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 12.23 12.35 12.09

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
65
Matched controls
650
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A98, ,
ICD-O-3
+∞
85.6
62
*
Q233, ,
ICD-10 Finland
Congenital mitral insufficiency
+∞
73.5
56
*
J01CA04, ,
ATC
amoxicillin; systemic
+∞
69.9
54
*
J01DB01, ,
ATC
cefalexin; oral
+∞
64.8
51
*
SAA02, ,
ICD-O-3
+∞
63.2
50
*
WX110, ,
ICD-O-3
+∞
52.3
43
*
FM1EE, ,
ICD-O-3
+∞
52.3
43
*
GD1AA, ,
ICD-O-3
+∞
50.8
42
*
SAA01, ,
ICD-O-3
+∞
48.0
40
*
N02BE01, ,
ATC
paracetamol; systemic, rectal
+∞
48.0
40
*
XF400, ,
ICD-O-3
+∞
43.8
37
*
WX408, ,
ICD-O-3
+∞
43.8
37
*
J01CE02, ,
ATC
phenoxymethylpenicillin; oral
+∞
43.8
37
*
J01CR02, ,
ATC
amoxicillin and beta-lactamase inhibitor; systemic
+∞
42.4
36
*
M01AE01, ,
ATC
ibuprofen; systemic, rectal
+∞
41.0
35
*
Z012, ,
ICD-O-3
+∞
41.0
35
*
FM1AE, ,
ICD-O-3
+∞
39.7
34
*
R4110, ,
ICD-O-3
+∞
38.4
33
*
Z3231, ,
ICD-O-3
+∞
38.4
33
*
R03AC02, ,
ATC
salbutamol; inhalant
+∞
37.1
32
*
FM1BE, ,
ICD-O-3
+∞
37.1
32
*
ZXD10, ,
ICD-O-3
+∞
37.1
32
*
EB1SA, ,
ICD-O-3
+∞
35.8
31
*
J01FA10, ,
ATC
azithromycin; systemic
+∞
35.8
31
*
Z2221, ,
ICD-O-3
+∞
35.8
31
*
ZXE00, ,
ICD-O-3
+∞
35.8
31
*
K021, ,
ICD-O-3
+∞
34.5
30
*
ZXE10, ,
ICD-O-3
+∞
34.5
30
*
J069, ,
ICD-O-3
+∞
34.5
30
*
ZXD05, ,
ICD-O-3
+∞
34.5
30
*
SAA03, ,
ICD-O-3
+∞
34.5
30
*
J01DA01, ,
ATC
[U] cefalexin
+∞
34.5
30
*
E0000UV, ,
ATC
+∞
33.2
29
*
B01AA03, ,
ATC
warfarin; systemic
+∞
33.2
29
*
WZC00, ,
ICD-O-3
+∞
31.9
28
*
SCA01, ,
ICD-O-3
+∞
31.9
28
*
GD1UA, ,
ICD-O-3
+∞
31.9
28
*
FXA00, ,
ICD-O-3
+∞
31.9
28
*
XF404, ,
ICD-O-3
+∞
31.9
28
*
EB1HA, ,
ICD-O-3
+∞
30.7
27
*
M01AE02, ,
ATC
naproxen; oral, rectal
+∞
30.7
27
*
A02BC02, ,
ATC
pantoprazole; systemic
+∞
30.7
27
*
C03CA01, ,
ATC
furosemide; systemic
+∞
30.7
27
*
201, ,
Kela drug reimbursment
Chronic cardiac insufficiency
+∞
29.4
26
*
SPAT1263, ,
ICD-O-3
+∞
29.4
26
*
ZXE20, ,
ICD-O-3
+∞
29.4
26
*
WX404, ,
ICD-O-3
+∞
29.4
26
*
SFA20, ,
ICD-O-3
+∞
29.4
26
*
SPAT1315, ,
ICD-O-3
+∞
28.2
25
*
C07AB07, ,
ATC
bisoprolol; oral
+∞
28.2
25
*
EB1AA, ,
ICD-O-3
+∞
28.2
25
*
WX700, ,
ICD-O-3
+∞
28.2
25
*
SFA10, ,
ICD-O-3
+∞
28.2
25
*
SPAT1312, ,
ICD-O-3
+∞
26.9
24
*
SPAT1256, ,
ICD-O-3
+∞
26.9
24
*
B01AB05, ,
ATC
enoxaparin; parenteral
+∞
26.9
24
*
J01AA02, ,
ATC
doxycycline; systemic
+∞
26.9
24
*
XF600, ,
ICD-O-3
+∞
25.7
23
*
TPH04, ,
ICD-O-3
+∞
25.7
23
*
SPAT1249, ,
ICD-O-3
+∞
25.7
23
*
-1, ,
ICD-O-3
+∞
25.7
23
*
WX402, ,
ICD-O-3
+∞
25.7
23
*
Z018, ,
ICD-10 Finland
Other specified special examinations
+∞
24.5
22
*
C03DA01, ,
ATC
spironolactone; oral
+∞
24.5
22
*
I3409, ,
ICD-10 Finland
Mitral (valve) insufficiency
+∞
24.5
22
*
R83, ,
ICD-O-3
+∞
24.5
22
*
Z3226, ,
ICD-O-3
+∞
24.5
22
*
WZB00, ,
ICD-O-3
+∞
23.3
21
*
R21, ,
ICD-O-3
+∞
23.3
21
*
XF402, ,
ICD-O-3
+∞
23.3
21
*
SPAT1317, ,
ICD-O-3
+∞
22.1
20
*
TPH07, ,
ICD-O-3
+∞
22.1
20
*
C09AA02, ,
ATC
enalapril; systemic
+∞
22.1
20
*
SPAT1325, ,
ICD-O-3
+∞
22.1
20
*
S18, ,
ICD-O-3
+∞
22.1
20
*
J069, ,
ICD-10 Finland
Acute upper respiratory infection, unspecified
+∞
22.1
20
*
KMAK, ,
ICD-O-3
+∞
22.1
20
*
K0364, ,
ICD-O-3
+∞
21.0
19
*
R74, ,
ICD-O-3
+∞
21.0
19
*
JN3AE, ,
ICD-O-3
+∞
21.0
19
*
WYA05, ,
ICD-O-3
+∞
21.0
19
*
A03, ,
ICD-O-3
+∞
19.8
18
*
TPH15, ,
ICD-O-3
+∞
19.8
18
*
LC2BE, ,
ICD-O-3
+∞
19.8
18
*
R06AE07, ,
ATC
cetirizine; oral
+∞
19.8
18
*
SDA01, ,
ICD-O-3
+∞
19.8
18
*
R01AD09, ,
ATC
mometasone; nasal
+∞
19.8
18
*
N06AB10, ,
ATC
escitalopram; oral
+∞
19.8
18
*
WX290, ,
ICD-O-3
+∞
19.8
18
*
EBA00, ,
ICD-O-3
+∞
19.8
18
*
VALMI, ,
ICD-O-3
+∞
18.6
17
*
J189, ,
ICD-10 Finland
Pneumonia, unspecified
+∞
18.6
17
*
N06AX11, ,
ATC
mirtazapine; oral
+∞
18.6
17
*
FM2CE, ,
ICD-O-3
+∞
18.6
17
*
Z004, ,
ICD-10 Finland
General psychiatric examination, not elsewhere classified
+∞
18.6
17
*
C01AA05, ,
ATC
digoxin; systemic
+∞
18.6
17
*
WZC30, ,
ICD-O-3
+∞
18.6
17
*
SPAT1253, ,
ICD-O-3
+∞
18.6
17
*
FM1DE, ,
ICD-O-3
+∞
18.6
17
*
Z2446, ,
ICD-O-3
+∞
17.5
16
*
WX892, ,
ICD-O-3
+∞
17.5
16
*
R01AD12, ,
ATC
fluticasone furoate; nasal
+∞
17.5
16
*
ZXE30, ,
ICD-O-3
+∞
17.5
16
*
FN1AC, ,
ICD-O-3
+∞
17.5
16
*
J01EE02, ,
ATC
sulfadiazine and trimethoprim; systemic
+∞
17.5
16
*
SCA02, ,
ICD-O-3
+∞
17.5
16
*
SDA02, ,
ICD-O-3
+∞
17.5
16
*
D82, ,
ICD-O-3
+∞
17.5
16
*
A09, ,
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
+∞
17.5
16
*
M03BX02, ,
ATC
tizanidine; oral
+∞
16.3
15
*
WX882, ,
ICD-O-3
+∞
16.3
15
*
J01FA06, ,
ATC
roxithromycin; oral
+∞
16.3
15
*
WX872, ,
ICD-O-3
+∞
16.3
15
*
C07AA05, ,
ATC
propranolol; systemic
+∞
16.3
15
*
SAB03, ,
ICD-O-3
+∞
16.3
15
*
I341, ,
ICD-10 Finland
Mitral (valve) prolapse
+∞
16.3
15
*
D07AC01, ,
ATC
betamethasone; topical
+∞
16.3
15
*
J01EA01, ,
ATC
trimethoprim; systemic
+∞
16.3
15
*
Z010, ,
ICD-10 Finland
Examination of eyes and vision
+∞
16.3
15
*
R074, ,
ICD-10 Finland
Chest pain, unspecified
+∞
16.3
15
*
R509, ,
ICD-10 Finland
Fever, unspecified
+∞
16.3
15
*
SPAT1310, ,
ICD-O-3
+∞
16.3
15
*
SDA03, ,
ICD-O-3
+∞
15.2
14
*
R03BA05, ,
ATC
fluticasone; inhalant
+∞
15.2
14
*
R06AX27, ,
ATC
desloratadine; oral
+∞
15.2
14
*
L17, ,
ICD-O-3
+∞
15.2
14
*
H02AB06, ,
ATC
prednisolone; systemic
+∞
15.2
14
*
R05FA02, ,
ATC
opium derivatives and expectorants; systemic
+∞
15.2
14
*
SPAT1301, ,
ICD-O-3
+∞
15.2
14
*
Z001, ,
ICD-O-3
+∞
14.0
13
*
J01CA08, ,
ATC
pivmecillinam; oral
+∞
14.0
13
*
WW200, ,
ICD-O-3
+∞
14.0
13
*
ZXE11, ,
ICD-O-3
+∞
14.0
13
*
M01AH05, ,
ATC
etoricoxib; oral
+∞
14.0
13
*
Z011, ,
ICD-10 Finland
Examination of ears and hearing
+∞
14.0
13
*
SPAT1316, ,
ICD-O-3
+∞
14.0
13
*
A02BC05, ,
ATC
esomeprazole; systemic
+∞
14.0
13
*
J01FA09, ,
ATC
clarithromycin; systemic
+∞
14.0
13
*
N02AJ06, ,
ATC
codeine and paracetamol; systemic
+∞
14.0
13
*
TFC99, ,
ICD-O-3
+∞
14.0
13
*
M796, ,
ICD-10 Finland
Pain in limb
+∞
14.0
13
*
Z871, ,
ICD-O-3
+∞
14.0
13
*
N05AH04, ,
ATC
quetiapine; oral
+∞
14.0
13
*
R05, ,
ICD-O-3
+∞
14.0
13
*
FM1DG, ,
ICD-O-3
+∞
14.0
13
*
I48, ,
ICD-10 Finland
Atrial fibrillation and flutter
+∞
14.0
13
*
N02CC01, ,
ATC
sumatriptan; nasal, systemic, rectal
+∞
12.9
12
*
SPAT1283, ,
ICD-O-3
+∞
12.9
12
*
P01, ,
ICD-O-3
+∞
12.9
12
*
SPAT1153, ,
ICD-O-3
+∞
12.9
12
*
SAB02, ,
ICD-O-3
+∞
12.9
12
*
H669, ,
ICD-10 Finland
Otitis media, unspecified
+∞
12.9
12
*
J05AB01, ,
ATC
aciclovir; systemic
+∞
12.9
12
*
J01MA02, ,
ATC
ciprofloxacin; systemic
+∞
12.9
12
*
Z718, ,
ICD-O-3
+∞
12.9
12
*
FN1BC, ,
ICD-O-3
+∞
12.9
12
*
WZA90, ,
ICD-O-3
+∞
12.9
12
*
R104, ,
ICD-10 Finland
Other and unspecified abdominal pain
+∞
12.9
12
*
Z718, ,
ICD-10 Finland
Other specified counselling
+∞
12.9
12
*
R01AD08, ,
ATC
fluticasone; nasal
+∞
12.9
12
*
XA800, ,
ICD-O-3
+∞
12.9
12
*
R104, ,
ICD-O-3
+∞
12.9
12
*
GAE10, ,
ICD-O-3
+∞
12.9
12
*
IGY02, ,
ICD-O-3
+∞
12.9
12
*
ZX120, ,
ICD-O-3
+∞
12.9
12
*
ZXA10, ,
ICD-O-3
+∞
12.9
12
*
207, ,
Kela drug reimbursment
Chronic arrhythmias
+∞
12.9
12
*
203, ,
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
+∞
12.9
12
*
XFP20, ,
ICD-O-3
+∞
12.9
12
*
UJD10, ,
ICD-O-3
+∞
12.9
12
*
D07AA02, ,
ATC
hydrocortisone; topical
+∞
12.9
12
*
H01, ,
ICD-O-3
+∞
12.9
12
*
ZYC01, ,
ICD-O-3
+∞
11.8
11
*
J459, ,
ICD-10 Finland
Asthma, unspecified
+∞
11.8
11
*
Q2109, ,
ICD-10 Finland
Ventricular septal defect NOS
+∞
11.8
11
*
ZXA00, ,
ICD-O-3
+∞
11.8
11
*
ZXA05, ,
ICD-O-3
+∞
11.8
11
*
C07AB02, ,
ATC
metoprolol; systemic
+∞
11.8
11
*
R1100, ,
ICD-O-3
+∞
11.8
11
*
R03BA02, ,
ATC
budesonide; inhalant
+∞
11.8
11
*
M01AB05, ,
ATC
diclofenac; systemic, rectal
+∞
11.8
11
*
I509, ,
ICD-10 Finland
Heart failure, unspecified
+∞
11.8
11
*
SAB01, ,
ICD-O-3
+∞
11.8
11
*
H660, ,
ICD-10 Finland
Acute suppurative otitis media
+∞
11.8
11
*
7466A, ,
ICD-9 Finland
Other congenital anomalies of heart, Congenital mitral insufficiency
+∞
11.8
11
*
SFA30, ,
ICD-O-3
+∞
11.8
11
*
Z3229, ,
ICD-O-3
+∞
11.8
11
*
OAB43, ,
ICD-O-3
+∞
11.8
11
*
L03, ,
ICD-O-3
+∞
11.8
11
*
SPAT1384, ,
ICD-O-3
+∞
11.8
11
*
Z315, ,
ICD-10 Finland
Genetic counselling
+∞
11.8
11
*
N05BA04, ,
ATC
oxazepam; oral
+∞
11.8
11
*
K020, ,
ICD-O-3
+∞
11.8
11
*
SPAT1223, ,
ICD-O-3
+∞
11.8
11
*
K0510, ,
ICD-O-3
+∞
11.8
11
*
Q203, ,
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
11.8
11
*
A12AX, ,
ATC
Calcium, combinations with vitamin D and/or other drugs
+∞
10.7
10
*
AA1AD, ,
ICD-O-3
+∞
10.7
10
*
I3400, ,
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
+∞
10.7
10
*
Z950, ,
ICD-10 Finland
Presence of electronic cardiac devices
+∞
10.7
10
*
IAZ97, ,
ICD-O-3
+∞
10.7
10
*
R060, ,
ICD-10 Finland
Dyspnoea
+∞
10.7
10
*
Z035, ,
ICD-10 Finland
Observation for other suspected cardiovascular diseases
+∞
10.7
10
*
H03AA01, ,
ATC
levothyroxine sodium; systemic
+∞
10.7
10
*
WX105, ,
ICD-O-3
+∞
10.7
10
*
Z011, ,
ICD-O-3
+∞
10.7
10
*
P03, ,
ICD-O-3
+∞
10.7
10
*
N03AX16, ,
ATC
[U] pregabalin
+∞
10.7
10
*
WX704, ,
ICD-O-3
+∞
10.7
10
*
P01AB01, ,
ATC
metronidazole; oral, rectal
+∞
10.7
10
*
ZXD30, ,
ICD-O-3
+∞
10.7
10
*
L15, ,
ICD-O-3
+∞
10.7
10
*
ZXD20, ,
ICD-O-3
+∞
10.7
10
*
S01XA20, ,
ATC
artificial tears and other indifferent preparations; ophthalmic
+∞
10.7
10
*
Q2100, ,
ICD-10 Finland
Multiple ventricular septal defect
+∞
10.7
10
*
S01CA01, ,
ATC
dexamethasone and antiinfectives; ophthalmic
+∞
10.7
10
*
Z2445, ,
ICD-O-3
+∞
10.7
10
*
F3210, ,
ICD-10 Finland
Moderate depressive episode without somatic syndrome
+∞
10.7
10
*
R03CC02, ,
ATC
salbutamol; systemic
+∞
10.7
10
*
EBA10, ,
ICD-O-3
+∞
10.7
10
*
E000001, ,
ATC
+∞
10.7
10
*
W01, ,
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
+∞
10.7
10
*
J451, ,
ICD-10 Finland
Nonallergic asthma
+∞
10.7
10
*
WX002, ,
ICD-O-3
+∞
10.7
10
*
PH2AE, ,
ICD-O-3
+∞
10.7
10
*
A97, ,
ICD-O-3
+∞
10.7
10
*
I499, ,
ICD-10 Finland
Cardiac arrhythmia, unspecified
+∞
9.6
9
*
N02AX02, ,
ATC
tramadol; systemic, rectal
+∞
9.6
9
*
Z0389, ,
ICD-10 Finland
Observation for other suspected diseases and conditions
+∞
9.6
9
*
Z039, ,
ICD-10 Finland
Observation for suspected disease or condition, unspecified
+∞
9.6
9
*
D01, ,
ICD-O-3
+∞
9.6
9
*
ZXE06, ,
ICD-O-3
+∞
9.6
9
*
M02AA07, ,
ATC
piroxicam; topical
+∞
9.6
9
*
ZXE40, ,
ICD-O-3
+∞
9.6
9
*
R42, ,
ICD-10 Finland
Dizziness and giddiness
+∞
9.6
9
*
SPAT1240, ,
ICD-O-3
+∞
9.6
9
*
N06AX16, ,
ATC
venlafaxine; oral
+∞
9.6
9
*
FN1BB, ,
ICD-O-3
+∞
9.6
9
*
SPAT1260, ,
ICD-O-3
+∞
9.6
9
*
SDE02, ,
ICD-O-3
+∞
9.6
9
*
J010, ,
ICD-O-3
+∞
9.6
9
*
GD1PA, ,
ICD-O-3
+∞
9.6
9
*
KH1AE, ,
ICD-O-3
+∞
9.6
9
*
ICZ03, ,
ICD-O-3
+∞
9.6
9
*
W11, ,
ICD-O-3
+∞
9.6
9
*
N01, ,
ICD-O-3
+∞
9.6
9
*
ZXE04, ,
ICD-O-3
+∞
9.6
9
*
Q2108, ,
ICD-10 Finland
Other specifed ventricular septal defect
+∞
9.6
9
*
A02BC01, ,
ATC
omeprazole; systemic
+∞
9.6
9
*
J02AC01, ,
ATC
fluconazole; systemic
+∞
9.6
9
*
Z258, ,
ICD-O-3
+∞
9.6
9
*
N06AB03, ,
ATC
fluoxetine; oral
+∞
9.6
9
*
WZC10, ,
ICD-O-3
+∞
9.6
9
*
R2130, ,
ICD-O-3
+∞
9.6
9
*
F510, ,
ICD-O-3
+∞
9.6
9
*
D19, ,
ICD-O-3
+∞
9.6
9
*
OAA40, ,
ICD-O-3
+∞
9.6
9
*
N10, ,
ICD-10 Finland
Acute tubulo-interstitial nephritis
+∞
8.5
8
*
Z952, ,
ICD-10 Finland
Presence of prosthetic heart valve
+∞
8.5
8
*
A084, ,
ICD-10 Finland
Viral intestinal infection, unspecified
+∞
8.5
8
*
WX320, ,
ICD-O-3
+∞
8.5
8
*
SPAT1308, ,
ICD-O-3
+∞
8.5
8
*
ICB01, ,
ICD-O-3
+∞
8.5
8
*
WZC05, ,
ICD-O-3
+∞
8.5
8
*
SDA04, ,
ICD-O-3
+∞
8.5
8
*
Q250, ,
ICD-10 Finland
Patent ductus arteriosus
+∞
8.5
8
*
RD210, ,
ICD-O-3
+∞
8.5
8
*
I471, ,
ICD-10 Finland
Supraventricular tachycardia
+∞
8.5
8
*
KA1MN, ,
ICD-O-3
+∞
8.5
8
*
F419, ,
ICD-O-3
+∞
8.5
8
*
W78, ,
ICD-O-3
+∞
8.5
8
*
LC2AE, ,
ICD-O-3
+∞
8.5
8
*
I10, ,
ICD-10 Finland
Essential (primary) hypertension
+∞
8.5
8
*
SCE00, ,
ICD-O-3
+∞
8.5
8
*
SBB10, ,
ICD-O-3
+∞
8.5
8
*
R06AX13, ,
ATC
loratadine; oral
+∞
8.5
8
*
R05FB02, ,
ATC
cough suppressants and expectorants; systemic
+∞
8.5
8
*
Q2110, ,
ICD-10 Finland
Persistent ostium secundum
+∞
8.5
8
*
J01FA01, ,
ATC
erythromycin; systemic
+∞
8.5
8
*
IEY05, ,
ICD-O-3
+∞
8.5
8
*
R01BA52, ,
ATC
pseudoephedrine, combinations; oral
+∞
8.5
8
*
MA2AE, ,
ICD-O-3
+∞
8.5
8
*
WYA50, ,
ICD-O-3
+∞
8.5
8
*
ZXE05, ,
ICD-O-3
+∞
8.5
8
*
D07AB02, ,
ATC
hydrocortisone butyrate; topical
+∞
8.5
8
*
M796, ,
ICD-O-3
+∞
8.5
8
*
I10, ,
ICD-O-3
+∞
8.5
8
*
Z712, ,
ICD-O-3
+∞
8.5
8
*
J01DA09, ,
ATC
[U] cefadroxil
+∞
8.5
8
*
K0365, ,
ICD-O-3
+∞
8.5
8
*
TFP20, ,
ICD-O-3
+∞
8.5
8
*
SPAT1262, ,
ICD-O-3
+∞
8.5
8
*
DFF00, ,
ICD-O-3
+∞
8.5
8
*
SPAT1363, ,
ICD-O-3
+∞
8.5
8
*
XF622, ,
ICD-O-3
+∞
8.5
8
*
A499, ,
ICD-10 Finland
Bacterial infection, unspecified
+∞
8.5
8
*
C10AA05, ,
ATC
atorvastatin; oral
+∞
7.4
7
*
IBA01, ,
ICD-O-3
+∞
7.4
7
*
I495, ,
ICD-10 Finland
Sick sinus syndrome
+∞
7.4
7
*
A03FA01, ,
ATC
metoclopramide; systemic, rectal
+∞
7.4
7
*
UKC02, ,
ICD-O-3
+∞
7.4
7
*
WYA30, ,
ICD-O-3
+∞
7.4
7
*
R03DC03, ,
ATC
montelukast; oral
+∞
7.4
7
*
I48, ,
ICD-O-3
+∞
7.4
7
*
N06AB06, ,
ATC
sertraline; oral
+∞
7.4
7
*
C01BD01, ,
ATC
amiodarone; systemic
+∞
7.4
7
*
U02, ,
ICD-O-3
+∞
7.4
7
*
R040, ,
ICD-10 Finland
Epistaxis
+∞
7.4
7
*
Z017, ,
ICD-10 Finland
Laboratory examination
+∞
7.4
7
*
C10AA01, ,
ATC
simvastatin; oral
+∞
7.4
7
*
ZY010, ,
ICD-O-3
+∞
7.4
7
*
Z363, ,
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
+∞
7.4
7
*
SCA03, ,
ICD-O-3
+∞
7.4
7
*
R4190, ,
ICD-O-3
+∞
7.4
7
*
N03AX09, ,
ATC
lamotrigine; oral
+∞
7.4
7
*
R31, ,
ICD-10 Finland
Unspecified haematuria
+∞
7.4
7
*
F329, ,
ICD-10 Finland
Depressive episode, unspecified
+∞
7.4
7
*
SDE03, ,
ICD-O-3
+∞
7.4
7
*
N05CF01, ,
ATC
zopiclone; oral
+∞
7.4
7
*
X59, ,
ICD-10 Finland
Exposure to unspecified factor
+∞
7.4
7
*
S01GX01, ,
ATC
cromoglicic acid; ophthalmic
+∞
7.4
7
*
XCW99, ,
ICD-O-3
+∞
7.4
7
*
O800, ,
ICD-10 Finland
Spontaneous vertex delivery
+∞
7.4
7
*
SXC05, ,
ICD-O-3
+∞
7.4
7
*
602, ,
Kela drug reimbursment
Children's severe malnutrition
+∞
7.4
7
*
Q203, ,
ICD-O-3
+∞
7.4
7
*
OAA67, ,
ICD-O-3
+∞
7.4
7
*
U01, ,
ICD-O-3
+∞
7.4
7
*
C09AA05, ,
ATC
ramipril; oral
+∞
7.4
7
*
DCA20, ,
ICD-O-3
+∞
7.4
7
*
J01DA08, ,
ATC
[U] cefaclor
+∞
7.4
7
*
ZXE13, ,
ICD-O-3
+∞
7.4
7
*
EBA05, ,
ICD-O-3
+∞
7.4
7
*
M01AE03, ,
ATC
ketoprofen; systemic, rectal
+∞
7.4
7
*
31, ,
ICD-O-3
+∞
7.4
7
*
A04, ,
ICD-O-3
+∞
7.4
7
*
Q233, ,
ICD-O-3
+∞
7.4
7
*
WZA00, ,
ICD-O-3
+∞
7.4
7
*
A23, ,
ICD-O-3
+∞
7.4
7
*
Z450, ,
ICD-10 Finland
Adjustment and management of cardiac devices
+∞
7.4
7
*
R53, ,
ICD-O-3
+∞
7.4
7
*
AA1CG, ,
ICD-O-3
+∞
7.4
7
*
H660, ,
ICD-O-3
+∞
7.4
7
*
GA1AE, ,
ICD-O-3
+∞
7.4
7
*
SAD01, ,
ICD-O-3
+∞
7.4
7
*
FKB10, ,
ICD-O-3
+∞
7.4
7
*
Z000, ,
ICD-10 Finland
General medical examination
+∞
7.4
7
*
SPAT1307, ,
ICD-O-3
+∞
7.4
7
*
SPAT1250, ,
ICD-O-3
+∞
7.4
7
*
XF640, ,
ICD-O-3
+∞
7.4
7
*
C08CA01, ,
ATC
amlodipine; oral
+∞
7.4
7
*
XLD00, ,
ICD-O-3
+∞
7.4
7
*
Z048, ,
ICD-10 Finland
Examination and observation for other specified reasons
+∞
7.4
7
*
OAB48, ,
ICD-O-3
+∞
7.4
7
*
G04BE03, ,
ATC
sildenafil; oral
+∞
7.4
7
*
61, ,
ICD-O-3
+∞
7.4
7
*
SPAT1379, ,
ICD-O-3
+∞
7.4
7
*
EB4VA, ,
ICD-O-3
+∞
7.4
7
*
TFB00, ,
ICD-O-3
+∞
7.4
7
*
XQ800, ,
ICD-O-3
+∞
7.4
7
*
SPAT1222, ,
ICD-O-3
+∞
7.4
7
*
ZXE03, ,
ICD-O-3
+∞
7.4
7
*
R101, ,
ICD-10 Finland
Pain localized to upper abdomen
+∞
6.3
6
*
R01AD58, ,
ATC
fluticasone, combinations; nasal
+∞
6.3
6
*
F321, ,
ICD-O-3
+∞
6.3
6
*
P06, ,
ICD-O-3
+∞
6.3
6
*
K0364, ,
ICD-10 Finland
Dental calculus supragingival
+∞
6.3
6
*
L02, ,
ICD-O-3
+∞
6.3
6
*
FPE20, ,
ICD-O-3
+∞
6.3
6
*
Q251, ,
ICD-10 Finland
Coarctation of aorta
+∞
6.3
6
*
EMB30, ,
ICD-O-3
+∞
6.3
6
*
J210, ,
ICD-10 Finland
Acute bronchiolitis due to respiratory syncytial virus
+∞
6.3
6
*
K0730, ,
ICD-O-3
+∞
6.3
6
*
U072, ,
ICD-O-3
+∞
6.3
6
*
C09CA06, ,
ATC
candesartan; oral
+∞
6.3
6
*
SPAT1254, ,
ICD-O-3
+∞
6.3
6
*
K0382, ,
ICD-O-3
+∞
6.3
6
*
S21, ,
ICD-O-3
+∞
6.3
6
*
N02AA59, ,
ATC
codeine, combinations excl. psycholeptics; systemic
+∞
6.3
6
*
H02AB04, ,
ATC
methylprednisolone; systemic
+∞
6.3
6
*
A06AC01, ,
ATC
ispaghula (psylla seeds); oral
+∞
6.3
6
*
JN3AA, ,
ICD-O-3
+∞
6.3
6
*
J459, ,
ICD-O-3
+∞
6.3
6
*
R03AC03, ,
ATC
terbutaline; inhalant
+∞
6.3
6
*
R03AK06, ,
ATC
salmeterol and fluticasone; inhalant
+∞
6.3
6
*
Z012, ,
ICD-10 Finland
Dental examination
+∞
6.3
6
*
I370, ,
ICD-10 Finland
Pulmonary valve stenosis
+∞
6.3
6
*
RS224, ,
ICD-O-3
+∞
6.3
6
*
111, ,
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
+∞
6.3
6
*
WX602, ,
ICD-O-3
+∞
6.3
6
*
F322, ,
ICD-10 Finland
Severe depressive episode without psychotic symptoms
+∞
6.3
6
*
K051, ,
ICD-O-3
+∞
6.3
6
*
504, ,
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
+∞
6.3
6
*
F329, ,
ICD-O-3
+∞
6.3
6
*
D10, ,
ICD-O-3
+∞
6.3
6
*
SJX10, ,
ICD-O-3
+∞
6.3
6
*
R53, ,
ICD-10 Finland
Malaise and fatigue
+∞
6.3
6
*
N05CF02, ,
ATC
zolpidem; oral
+∞
6.3
6
*
FXA10, ,
ICD-O-3
+∞
6.3
6
*
TFC00, ,
ICD-O-3
+∞
6.3
6
*
I501, ,
ICD-10 Finland
Left ventricular failure
+∞
6.3
6
*
I493, ,
ICD-10 Finland
Ventricular premature depolarization
+∞
6.3
6
*
M03BC51, ,
ATC
orphenadrine, combinations; systemic
+∞
6.3
6
*
MA2HE, ,
ICD-O-3
+∞
6.3
6
*
H669, ,
ICD-O-3
+∞
6.3
6
*
D06, ,
ICD-O-3
+∞
6.3
6
*
Z712, ,
ICD-10 Finland
Person consulting for explanation of investigation findings
+∞
6.3
6
*
SAA04, ,
ICD-O-3
+∞
6.3
6
*
Z033, ,
ICD-10 Finland
Observation for suspected nervous system disorder
+∞
6.3
6
*
SPAT1220, ,
ICD-O-3
+∞
6.3
6
*
H02AB09, ,
ATC
hydrocortisone; systemic
+∞
6.3
6
*
D09, ,
ICD-O-3
+∞
6.3
6
*
H653, ,
ICD-10 Finland
Chronic mucoid otitis media
+∞
6.3
6
*
J01FF01, ,
ATC
clindamycin; systemic
+∞
6.3
6
*
I351, ,
ICD-10 Finland
Aortic (valve) insufficiency
+∞
6.3
6
*
H66, ,
ICD-O-3
+∞
6.3
6
*
R5110, ,
ICD-O-3
+∞
6.3
6
*
JN1AE, ,
ICD-O-3
+∞
6.3
6
*
K021, ,
ICD-10 Finland
Caries of dentine
+∞
6.3
6
*
R09, ,
ICD-O-3
+∞
6.3
6
*
S060, ,
ICD-10 Finland
Concussion
+∞
6.3
6
*
SPAT1216, ,
ICD-O-3
+∞
6.3
6
*
D06BX01, ,
ATC
metronidazole; topical
+∞
6.3
6
*
SPAT1197, ,
ICD-O-3
+∞
6.3
6
*
I489, ,
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
+∞
6.3
6
*
B349, ,
ICD-10 Finland
Viral infection, unspecified
+∞
6.3
6
*
GD1QA, ,
ICD-O-3
+∞
6.3
6
*
SBB00, ,
ICD-O-3
+∞
6.3
6
*
M01AG02, ,
ATC
tolfenamic acid; oral, rectal
+∞
6.3
6
*
SFC01, ,
ICD-O-3
+∞
6.3
6
*
SPAT1385, ,
ICD-O-3
+∞
6.3
6
*
Z017, ,
ICD-O-3
+∞
6.3
6
*
X58, ,
ICD-10 Finland
Exposure to other specified factors
+∞
6.3
6
*
R568, ,
ICD-10 Finland
Other and unspecified convulsions
+∞
6.3
6
*
NK6MA, ,
ICD-O-3
+∞
6.3
6
*
SPAT1364, ,
ICD-O-3
+∞
6.3
6
*
Z637, ,
ICD-10 Finland
Other stressful life events affecting family and household
+∞
6.3
6
*
ZXE02, ,
ICD-O-3
+∞
6.3
6
*
G431, ,
ICD-10 Finland
Migraine with aura [classical migraine]
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
137
6.84
13.45
33.4
9.8
1.74
1.24
inr
—
9
45
29
68
6.89
13.12
11.2
4.9
34.32
28.75
s
1.95
29
68
28
67
6.58
12.31
8.7
3.7
2200.14
428.05
ng/l
1.08
22
43
27
95
4.15
7.00
6.9
3.7
—
—
—
0
0
32
136
3.66
6.19
4.9
2.7
—
—
—
0
0
20
62
4.22
6.06
9.3
3.1
—
—
—
0
0
26
111
3.24
4.79
6.0
2.5
32.62
46.34
ng/l
0.19
20
51
16
51
3.84
4.57
2.6
3.2
—
—
—
0
0
8
10
8.93
4.19
2.5
4.8
33.63
37.40
umol/l
—
8
10
23
98
3.08
4.18
6.5
3.4
1.36
1.91
mg/l
0.22
17
64
7
7
11.01
4.11
3.0
3.9
578.00
162.39
ug/l
—
7
7
11
25
5.07
3.83
1.6
2.7
9.78
4.89
ug/l
0.79
11
19
39
232
2.70
3.70
16.1
12.7
1.21
1.22
mmol/l
1.77
39
211
18
71
3.12
3.68
19.3
10.0
—
—
—
0
0
7
9
8.54
3.65
4.4
2.2
—
—
—
0
0
7
10
7.68
3.46
4.4
2.2
—
—
—
0
0
6
7
9.28
3.33
1.0
1.0
—
—
—
0
0
19
83
2.82
3.22
11.8
9.8
—
—
—
0
0
36
217
2.48
3.17
18.5
13.3
1.21
1.23
mmol/l
1.90
36
208
39
244
2.50
3.17
6.8
2.7
—
—
—
0
0
14
52
3.16
3.12
1.3
1.2
—
—
—
0
0
8
18
4.91
2.90
10.5
39.4
—
—
—
0
0
19
89
2.60
2.79
13.5
14.8
24.59
24.73
mmol/l
0.08
19
89
12
42
3.27
2.73
1.6
1.9
—
—
—
0
0
30
179
2.26
2.57
11.5
7.3
—
—
—
0
0
9
27
3.70
2.50
9.8
15.2
125.00
132.74
g/l
—
9
27
8
22
3.99
2.45
4.8
3.5
—
—
—
0
0
8
22
3.99
2.45
2.4
1.6
—
—
—
0
0
38
254
2.19
2.43
3.8
3.2
87.14
70.31
ug/l
0.35
38
239
17
84
2.39
2.20
7.2
9.0
23.29
23.48
mmol/l
0.12
17
84
13
57
2.60
2.14
3.0
1.9
—
—
—
0
0
7
23
3.28
1.86
7.4
16.8
1.29
1.67
%
—
7
23
12
55
2.45
1.80
7.2
12.5
105.25
104.93
mmol/l
0.11
12
55
7
24
3.14
1.78
1.7
1.3
—
—
—
0
0
7
24
3.14
1.78
2.0
6.0
—
—
—
0
0
6
20
3.20
1.62
12.0
12.4
24.33
24.30
mmol/l
—
6
20
6
21
3.04
1.54
8.5
18.3
0.75
0.65
%
—
6
21
17
98
1.99
1.49
1.4
1.5
—
—
—
0
0
6
22
2.90
1.47
12.2
11.6
84.33
93.94
%
—
6
22
6
22
2.90
1.47
14.3
6.2
25.22
23.43
mmol/l
—
6
22
21
132
1.87
1.44
2.4
2.8
—
—
—
0
0
6
23
2.77
1.40
12.2
11.2
0.52
0.59
%
—
6
23
23
153
1.78
1.30
3.8
3.7
—
—
—
0
0
17
103
1.88
1.29
21.2
9.7
1.21
1.29
mmol/l
0.48
17
98
21
138
1.77
1.23
3.4
2.7
50.33
55.62
u/l
0.28
21
128
59
527
2.29
1.21
31.0
11.9
23.52
21.73
mg/l
0.20
46
379
5
21
2.49
1.11
1.8
2.0
—
—
—
0
0
39
310
1.65
1.11
11.1
8.2
59.26
51.62
%
3.68
39
298
38
301
1.63
1.09
12.0
8.8
8.70
8.25
%
0.45
38
290
38
301
1.63
1.09
11.8
8.4
3.13
3.11
%
0.01
38
290
19
127
1.70
1.04
1.6
1.6
87.81
95.64
pmol/l
0.47
14
66
9
49
1.97
1.04
6.8
7.6
57.11
52.02
ng/l
—
9
49
27
200
1.60
0.99
5.8
4.5
17.75
58.31
e6/l
0.99
22
142
6
27
2.34
0.96
3.7
5.0
6.02
17.19
umol/l
—
6
18
19
130
1.65
0.95
3.2
2.1
—
—
—
0
0
6
28
2.26
0.94
1.8
2.0
69.75
65.30
g/l
—
6
28
37
299
1.55
0.92
10.8
8.7
—
—
—
0
0
36
292
1.52
0.86
12.3
8.8
0.54
0.65
%
0.72
36
280
38
312
1.52
0.86
11.9
8.4
25.89
34.04
%
4.62
38
302
21
152
1.56
0.83
1.5
1.7
—
—
—
0
0
47
406
1.57
0.82
4.0
3.1
1.36
1.42
mmol/l
0.41
47
379
0
26
0.00
0.80
0.0
1.1
—
3.69
—
0
19
5
23
2.27
0.78
12.8
11.2
0.90
1.29
%
—
5
23
10
61
1.76
0.73
1.2
1.4
—
—
—
0
0
5
26
2.00
0.72
1.0
1.3
0.24
0.24
g/l
—
5
26
5
27
1.92
0.70
1.2
1.3
0.90
1.31
g/l
—
5
27
5
29
1.78
0.65
2.4
2.2
—
—
—
0
0
5
29
1.78
0.65
1.0
1.1
—
—
—
0
0
5
87
0.54
0.61
1.4
1.1
—
—
—
0
0
8
53
1.58
0.61
4.1
1.8
—
—
—
0
0
0
22
0.00
0.60
0.0
1.2
—
7.89
—
0
13
0
22
0.00
0.60
0.0
1.1
—
0.04
—
0
10
9
60
1.58
0.57
1.4
1.2
194.56
519.77
u/ml
—
9
55
6
37
1.68
0.57
3.5
1.4
—
—
—
0
0
40
349
1.38
0.55
5.6
4.1
—
—
—
0
0
56
523
1.51
0.49
38.7
14.7
13.41
13.73
%
0.76
56
516
41
364
1.34
0.48
5.0
4.6
9.22
8.81
mm/h
0.09
41
340
19
150
1.38
0.47
2.2
1.8
—
—
—
0
0
22
181
1.33
0.42
1.6
1.6
—
—
—
0
0
23
191
1.32
0.41
1.7
2.2
—
—
—
0
0
5
34
1.51
0.41
4.2
6.9
—
0.08
—
0
13
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
11.71
—
0
13
5
35
1.46
0.40
1.8
1.3
—
—
—
0
0
16
126
1.36
0.40
3.9
2.9
—
—
—
0
0
18
219
0.75
0.40
1.7
1.7
0.82
2.59
u/ml
—
5
43
9
124
0.68
0.40
1.2
1.8
—
—
—
0
0
16
128
1.33
0.36
2.8
3.5
0.00
0.00
estimate
—
6
48
6
43
1.43
0.36
3.7
1.4
—
—
—
0
0
28
253
1.19
0.22
3.7
3.2
0.00
0.00
estimate
—
6
49
0
10
0.00
0.21
0.0
1.0
—
30.13
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
3.17
—
0
6
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
51
1.19
0.20
3.7
1.4
—
—
—
0
0
15
130
1.20
0.17
2.5
3.3
—
—
—
0
0
27
251
1.13
0.13
5.6
4.5
0.00
0.00
estimate
—
6
49
6
53
1.15
0.09
3.7
1.4
—
—
—
0
0
6
54
1.12
0.09
3.7
1.4
—
—
—
0
0
6
54
1.12
0.09
1.7
2.4
—
—
—
0
0
6
54
1.12
0.09
4.0
1.4
—
—
—
0
0
5
61
0.80
0.08
4.8
3.9
2.49
1.57
ug/l
—
5
55
27
257
1.09
0.07
3.7
3.2
0.00
0.00
estimate
—
6
45
13
134
0.96
0.00
1.5
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
5.78
—
0
6
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
12.7
—
7.50
—
0
6
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
18.8
—
1031.67
—
0
6
0
6
0.00
0.00
0.0
1.2
—
268.83
—
0
6
0
6
0.00
0.00
0.0
8.8
—
457.33
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
3.98
—
0
8
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
234.50
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
167.60
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.3
—
33.86
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
2.66
—
0
7
0
7
0.00
-0.00
0.0
3.4
—
3.23
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
25.34
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
1.20
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
32.27
—
0
8
0
9
0.00
-0.00
0.0
2.0
—
0.48
—
0
9

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: Q17_CONGENITAL_MITRAL_VALVE_REGURGITATION – Congenital mitral valve regurgitation

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).