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Congenital mitral valve regurgitation

Endpoint Browser PheWeb

Q17_CONGENITAL_MITRAL_VALVE_REGURGITATION

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q23.3
  • Hospital discharge: ICD-9 — 7466A
  • Cause of death: ICD-10 — Q23.3
  • Cause of death: ICD-9 — 7466A

2 out of 7 registries used, show all original rules.

68

4. Check minimum number of events

None

68

5. Include endpoints

None

68

6. Filter based on genotype QC (FinnGen only)

62

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 62 35 27
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 12.76 12.35 13.30

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
65
Matched controls
650
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
+∞
73.5
56
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
16.5
30.2
43
69
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
16.9
30.1
35
42
B01AA03
ATC
warfarin; systemic
17.3
27.7
29
29
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
50.7
27.0
32
12
XF400
NOMESCO Finland
ECG with 12 standard connections
11.7
23.1
37
66
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
43.3
22.9
28
11
201
Kela drug reimbursment
Chronic cardiac insufficiency
49.8
22.9
27
9
XF404
NOMESCO Finland
Ambulatory ECG
29.6
20.7
28
16
C03CA01
ATC
furosemide; systemic
11.4
20.6
29
43
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
64.9
19.7
22
5
ZXE20
NOMESCO Finland
More than three and less than five hours
11.4
19.4
26
36
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
9.1
17.1
29
53
XF402
NOMESCO Finland
ECG with work load test
30.1
15.9
21
10
XF600
NOMESCO Finland
Bloodpressure measurement
9.6
15.6
23
35
C03DA01
ATC
spironolactone; oral
17.8
13.9
22
18
C01AA05
ATC
digoxin; systemic
32.1
13.3
17
7
WX872
NOMESCO Finland
Intensive care
38.2
12.3
15
5
WX408
NOMESCO Finland
General anesthesy, balanced
6.0
11.8
37
118
7466A
ICD-9 Finland
Other congenital anomalies of heart, Congenital mitral insufficiency
+∞
11.8
11
*
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
11.8
11
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
31.8
11.8
15
6
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.9
11.2
43
162
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
39.8
10.8
13
*
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
130.1
10.8
11
*
TPH07
NOMESCO Finland
Cathetrisation of artery
7.0
10.6
20
39
C09AA02
ATC
enalapril; systemic
9.8
10.1
21
30
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
36.1
9.8
12
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
22.7
9.4
13
7
ZXE30
NOMESCO Finland
More than five and less than seven hours
12.1
8.9
16
17
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
24.0
8.8
12
6
FM2CE, ,
NOMESCO Finland
10.5
8.8
17
21
B01AB05
ATC
enoxaparin; parenteral
5.2
8.7
24
66
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
9.1
8.5
18
26
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
+∞
8.5
8
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.9
8.4
25
73
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
38.7
8.3
10
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.5
8.1
18
28
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
89.9
7.6
8
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
+∞
7.4
7
*
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
+∞
7.4
7
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
23.2
7.4
10
5
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
23.2
7.4
10
5
R4110
NOMESCO Finland
Physiotherapy
4.1
7.3
32
124
XF622
NOMESCO Finland
Measurement of minute volume of heart
44.8
6.9
8
*
WX892
NOMESCO Finland
Monitored bed care
7.5
6.9
16
27
I48
ICD-10 Finland
Atrial fibrillation and flutter
9.1
6.9
14
19
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
11.0
6.6
12
13
XF640, ,
NOMESCO Finland
77.1
6.6
7
*
61
HP
Catheterization and pressure measurement of the left side of the heart
77.1
6.6
7
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.7
6.4
16
30
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
+∞
6.3
6
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
6.3
6
*
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
+∞
6.3
6
*
207
Kela drug reimbursment
Chronic arrhythmias
9.5
6.2
12
15
Z2221
NOMESCO Finland
Medical doctor
3.6
6.1
31
130
C07AB07
ATC
bisoprolol; oral
3.8
6.1
26
97
ZXD05
NOMESCO Finland
Urgent procedure
3.6
6.0
30
124

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
30
74
6.67
12.85
11.1
5.2
34.01
28.47
s
1.99
30
74
30
77
6.38
12.25
9.1
3.9
2133.20
396.06
ng/l
1.23
25
47
24
81
4.11
6.53
8.2
2.9
—
—
—
0
0
27
108
3.57
5.65
7.1
3.8
—
—
—
0
0
33
155
3.29
5.28
5.2
3.0
—
—
—
0
0
8
7
12.79
4.93
3.0
3.9
508.50
162.39
ug/l
—
8
7
18
61
3.70
4.73
2.4
3.1
—
—
—
0
0
46
276
3.28
4.66
7.5
2.9
—
—
—
0
0
27
123
3.04
4.40
7.0
2.8
32.72
46.68
ng/l
0.23
20
61
40
227
2.98
4.37
5.1
3.5
—
—
estimate
—
0
0
9
13
7.83
4.32
2.4
4.6
37.44
34.15
umol/l
—
9
13
15
49
3.68
4.12
1.6
2.0
—
—
—
0
0
7
7
11.01
4.11
2.4
1.6
—
—
—
0
0
7
7
11.01
4.11
2.4
1.6
—
—
—
0
0
7
7
11.01
4.11
2.4
1.6
—
—
—
0
0
7
7
11.01
4.11
2.4
1.6
—
—
—
0
0
18
68
3.28
3.97
7.7
17.6
106.61
105.31
mmol/l
0.63
18
68
6
5
13.01
3.84
10.8
2.8
98.83
95.00
mg/l
—
6
5
7
9
8.54
3.65
4.4
2.2
0.71
0.89
index
—
7
9
22
98
2.88
3.64
12.8
10.3
—
—
—
0
0
18
74
2.98
3.41
19.3
10.5
—
—
—
0
0
23
109
2.72
3.37
6.8
3.4
1.31
1.79
mg/l
0.22
18
74
41
261
2.55
3.23
18.0
14.3
1.20
1.22
mmol/l
1.86
41
240
6
8
8.11
3.12
1.0
1.0
—
—
—
0
0
15
59
3.01
3.04
1.3
1.2
—
—
—
0
0
21
101
2.59
2.94
14.7
19.1
24.34
24.71
mmol/l
0.27
21
101
19
87
2.67
2.93
21.5
10.1
7.42
7.40
ph
0.90
19
71
23
116
2.52
2.93
10.3
12.3
7.38
7.37
ph
0.12
18
73
33
200
2.32
2.77
10.8
7.0
—
—
—
0
0
37
240
2.26
2.60
20.5
15.6
1.20
1.22
mmol/l
2.08
37
232
15
65
2.70
2.54
2.8
2.0
—
—
—
0
0
9
28
3.56
2.41
12.4
12.3
0.50
0.58
%
—
9
28
9
28
3.56
2.41
12.3
12.2
23.56
24.23
mmol/l
—
9
28
24
135
2.23
2.33
4.5
3.7
7.38
7.40
ph
1.01
17
95
9
29
3.43
2.33
12.4
12.0
97.44
93.05
%
—
9
29
19
98
2.33
2.24
7.3
12.8
23.82
23.50
mmol/l
0.20
19
98
10
38
2.92
2.11
1.7
2.2
—
—
—
0
0
8
28
3.11
1.93
2.5
1.7
—
—
—
0
0
41
299
2.01
1.90
5.0
3.8
69.70
68.91
ug/l
0.02
41
287
26
163
1.99
1.85
3.5
3.3
2.65
2.45
mg/l
0.19
26
142
8
30
2.89
1.79
12.9
11.7
0.86
1.21
%
—
8
30
8
31
2.80
1.72
1.9
2.5
68.44
64.67
g/l
—
8
31
8
31
2.80
1.72
6.9
25.4
1.22
1.52
%
—
8
31
10
42
2.63
1.71
3.9
7.6
—
0.08
—
0
13
43
328
1.92
1.65
11.4
9.5
57.90
51.97
%
2.53
43
323
24
152
1.92
1.63
3.1
2.9
85.21
55.11
u/l
0.42
24
144
6
20
3.20
1.62
1.2
33.0
69.38
67.84
%
—
6
20
6
20
3.20
1.62
1.5
2.2
—
—
—
0
0
7
27
2.78
1.56
1.7
1.3
—
—
—
0
0
34
244
1.82
1.55
9.7
9.9
—
—
—
0
0
7
29
2.58
1.43
1.0
1.3
0.22
0.24
g/l
—
7
29
18
108
1.92
1.41
1.4
1.6
—
—
—
0
0
0
37
0.00
1.39
0.0
1.1
—
7.78
—
0
26
11
55
2.20
1.37
6.8
8.5
59.55
62.49
ng/l
0.10
11
55
22
143
1.81
1.35
2.4
2.8
—
—
—
0
0
5
19
2.76
1.24
1.2
33.4
69.20
70.53
%
—
5
19
18
113
1.82
1.22
21.9
11.8
1.19
1.27
mmol/l
0.49
18
105
0
34
0.00
1.20
0.0
1.1
—
14.60
—
0
21
7
30
2.49
1.16
7.7
26.3
0.73
0.61
%
—
7
30
7
30
2.49
1.16
1.1
1.3
0.97
1.28
g/l
—
7
30
24
168
1.68
1.12
4.2
3.9
—
—
estimate
—
0
0
5
21
2.49
1.11
6.4
8.9
37.00
36.91
°c
—
5
21
45
372
1.68
1.09
14.1
11.1
3.70
3.76
e9/l
0.08
40
313
60
550
2.18
1.00
34.5
13.8
22.47
22.47
mg/l
0.00
52
416
30
229
1.58
0.97
6.4
5.1
16.36
76.21
e6/l
0.91
24
158
6
27
2.34
0.96
1.0
1.3
—
—
—
0
0
6
30
2.10
0.89
4.2
5.2
6.08
14.25
umol/l
—
6
21
6
32
1.96
0.84
1.0
1.1
—
—
—
0
0
5
23
2.27
0.78
1.4
1.0
—
—
—
0
0
23
173
1.51
0.76
1.7
1.7
88.90
96.23
pmol/l
0.50
16
94
22
165
1.50
0.74
1.6
1.8
—
—
—
0
0
60
556
2.03
0.73
33.8
13.6
67.47
66.28
umol/l
0.16
60
549
11
70
1.69
0.70
1.5
1.5
—
—
—
0
0
50
445
1.54
0.69
4.7
3.7
1.39
1.41
mmol/l
0.15
50
420
0
19
0.00
0.61
0.0
1.3
—
—
—
0
0
25
201
1.40
0.57
1.6
1.7
—
—
—
0
0
25
203
1.38
0.53
1.9
2.4
—
—
—
0
0
15
112
1.44
0.50
3.3
4.0
4.54
2.37
e6/l
—
10
69
7
46
1.58
0.50
3.4
1.7
—
—
—
0
0
48
435
1.40
0.50
6.2
4.1
15.36
14.45
pmol/l
1.64
48
400
19
150
1.38
0.47
3.2
3.5
0.00
0.00
estimate
—
9
59
20
160
1.36
0.46
3.7
2.4
—
—
—
0
0
0
15
0.00
0.42
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
11.71
—
0
13
9
69
1.35
0.39
1.4
3.4
3.32
3.98
e9/l
—
9
64
7
55
1.31
0.31
3.6
1.7
—
—
—
0
0
7
55
1.31
0.31
1.7
2.5
—
—
—
0
0
16
131
1.29
0.31
3.6
3.1
1.01
1.02
kg/l
—
10
87
20
169
1.26
0.31
2.3
1.8
—
—
—
0
0
8
61
1.35
0.30
4.5
1.9
—
—
—
0
0
16
133
1.27
0.27
8.1
6.1
—
—
—
0
0
5
37
1.38
0.24
1.8
1.3
—
—
—
0
0
8
101
0.76
0.23
1.4
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
27.58
—
0
11
0
11
0.00
0.21
0.0
2.2
—
0.54
—
0
11
0
14
0.00
0.20
0.0
1.0
—
3.23
—
0
7
21
235
0.84
0.20
1.9
1.9
0.82
2.91
u/ml
—
5
51
7
62
1.14
0.18
3.6
1.7
—
—
—
0
0
5
65
0.75
0.18
4.8
1.7
—
—
—
0
0
14
161
0.83
0.17
1.6
2.0
—
—
—
0
0
17
153
1.15
0.13
4.4
2.8
0.00
0.00
estimate
—
8
45
24
225
1.11
0.09
2.0
1.8
1.95
1.80
g/l
0.19
17
126
7
64
1.10
0.08
3.6
1.7
—
—
—
0
0
7
64
1.10
0.08
3.6
1.7
—
—
—
0
0
7
65
1.09
0.08
3.9
1.7
—
—
—
0
0
17
158
1.10
0.07
3.3
3.6
—
—
—
0
0
22
208
1.09
0.06
4.0
3.1
0.00
0.02
estimate
—
8
47
13
140
0.91
0.05
1.5
2.0
—
—
—
0
0
26
251
1.06
0.03
4.4
3.2
6.43
6.25
ph
0.34
14
124
30
309
0.95
0.03
4.7
3.5
0.00
0.00
estimate
—
9
55
31
307
1.02
0.00
4.6
3.5
0.00
0.00
estimate
—
9
60
30
302
0.99
0.00
4.6
3.5
0.00
0.00
estimate
—
9
61
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
30.27
—
0
6
0
6
0.00
0.00
0.0
1.0
—
170.50
—
0
6
0
6
0.00
0.00
0.0
2.2
—
0.47
—
0
6
0
6
0.00
0.00
0.0
1.3
—
0.00
—
0
6
0
7
0.00
-0.00
0.0
11.4
—
605.14
—
0
7
0
7
0.00
-0.00
0.0
1.9
—
5.81
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
90.80
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
266.75
—
0
8
0
7
0.00
-0.00
0.0
15.1
—
8.36
—
0
7
0
5
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.6
—
2.54
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
2.66
—
0
7
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.6
—
21.54
—
0
5
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
18.7
—
1102.71
—
0
7
0
9
0.00
-0.00
0.0
1.4
—
3.54
—
0
9
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
67
0.89
-0.00
4.5
4.3
2.04
1.46
ug/l
—
6
62
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: Q17_CONGENITAL_MITRAL_VALVE_REGURGITATION – Congenital mitral valve regurgitation

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).