This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Use of trihexyphenidyl
PDMED_TRIHEXYPHENIDYL
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
64 |
4. Check minimum number of events
Min. number of events
3
|
64 |
5. Include endpointsNone |
64 |
6. Filter based on genotype QC (FinnGen only) |
64 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
Use of trihexyphenidyl
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 64 | 33 | 31 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 51.46 | 41.66 | 61.88 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 59
- Matched controls
- 592
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N04AA01
ATC
trihexyphenidyl; oral
+∞
82.8
59
*
N04AA02
ATC
biperiden; systemic
361.0
36.2
33
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
96.2
30.5
32
7
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
43.1
27.7
35
19
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
56.0
20.9
24
7
N05BA06
ATC
lorazepam; systemic, sublingual
39.1
19.3
24
10
N05AF05
ATC
zuclopenthixol; systemic
252.9
18.6
18
*
N05AH03
ATC
olanzapine; systemic
36.5
18.2
23
10
N05AA02
ATC
levomepromazine; systemic
37.8
17.6
22
9
F20.9
ICD-10 Finland
Schizophrenia, unspecified
49.0
17.1
20
6
G20
ICD-10 Finland
Parkinson disease
36.7
16.0
20
8
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
32.6
15.5
20
9
N05AX08
ATC
risperidone; systemic
17.1
14.2
23
21
N03AE01
ATC
clonazepam; systemic
20.9
12.3
18
12
N05AH02
ATC
clozapine; systemic
81.6
12.1
13
*
F20
ICD-10 Finland
Schizophrenia
147.7
11.9
12
*
N05AF03
ATC
chlorprothixene; systemic
44.9
11.9
14
*
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
40.8
10.8
13
*
N05BA01
ATC
diazepam; systemic, rectal
8.9
10.7
25
45
188
Kela drug reimbursment
Psychosis requiring demanding treatment
+∞
9.6
9
*
3320A
ICD-9 Finland
Parkinson's disease, Paralysis agitans
+∞
9.6
9
*
N05AB03
ATC
perphenazine; systemic, rectal
16.2
9.5
15
12
N04BD01
ATC
selegiline; oral
59.1
9.0
10
*
N05AH04
ATC
quetiapine; oral
7.3
8.9
23
47
N05AX12
ATC
aripiprazole; systemic
33.1
8.8
11
*
P72
ICPC
Schizophrenia
33.1
8.8
11
*
F20.0
ICD-10 Finland
Paranoid schizophrenia
52.2
8.0
9
*
N03AG01
ATC
valproic acid; systemic, rectal
22.0
7.9
11
6
U04
ICPC
Incontinence urine
18.9
7.6
11
7
F20.1
ICD-10 Finland
Hebephrenic schizophrenia
+∞
7.4
7
*
N04BX02
ATC
entacapone; oral
+∞
7.4
7
*
N05CD07
ATC
temazepam; oral
5.9
7.3
22
54
N04BB01
ATC
amantadine; oral
26.0
6.9
9
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
11.2
6.7
12
13
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
77.9
6.6
7
*
N05AC02
ATC
thioridazine; oral
30.3
6.4
8
*
AA400
NOMESCO Finland
Electroconvulsive therapy
+∞
6.4
6
*
F20.3
ICD-10 Finland
Undifferentiated schizophrenia
+∞
6.4
6
*
N05AD01
ATC
haloperidol; systemic
14.7
6.3
10
8
A06AD11
ATC
lactulose; oral
5.0
6.1
21
59
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
41
10.66
18.72
7.1
3.6
—
—
—
0
0
32
127
4.04
7.04
6.9
3.5
0.00
0.00
estimate
0.00
23
40
11
18
7.17
6.67
7.6
4.5
26.82
24.91
mmol/l
0.45
11
18
25
95
3.68
5.67
2.2
1.9
392.87
550.51
pmol/l
2.06
15
86
10
18
6.40
5.51
2.1
1.4
—
—
—
0
0
34
176
2.99
4.44
6.9
3.6
—
—
—
0
0
21
98
2.70
3.15
3.1
1.5
1659.82
1221.70
nmol/l
1.11
11
77
17
71
2.90
3.12
2.3
2.0
—
—
—
0
0
36
221
2.44
3.02
6.9
3.6
0.00
0.00
estimate
0.00
24
42
35
223
2.26
2.58
7.8
4.8
0.00
0.00
estimate
0.00
20
42
35
225
2.23
2.50
6.8
3.6
0.00
0.00
estimate
0.00
24
37
5
9
5.91
2.25
2.0
1.3
—
—
—
0
0
8
25
3.50
2.18
1.8
1.8
—
—
—
0
0
26
170
1.89
1.61
4.3
3.1
—
—
—
0
0
24
158
1.83
1.43
2.6
2.6
57.65
56.87
u/l
0.04
17
145
33
246
1.70
1.25
16.4
11.0
4.41
3.91
e9/l
0.64
28
211
29
213
1.66
1.14
5.3
6.0
1.21
1.21
mmol/l
0.02
15
187
16
100
1.80
1.10
2.8
2.1
4.88
3.13
mg/l
0.39
11
86
5
102
0.45
1.00
2.0
2.3
—
—
—
0
0
0
30
0.00
1.00
0.0
1.7
—
—
—
0
0
9
55
1.74
0.78
1.8
1.9
—
—
—
0
0
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
27
218
1.41
0.61
2.7
2.9
—
—
—
0
0
8
53
1.58
0.61
1.9
1.8
—
—
—
0
0
0
23
0.00
0.59
0.0
1.3
—
—
—
0
0
19
145
1.44
0.58
2.7
3.6
1762.29
1308.87
ng/l
0.32
14
124
15
110
1.47
0.55
1.3
1.7
1.05
1.38
mmol/l
—
8
86
37
320
1.37
0.54
3.8
4.5
10.00
12.12
mm/h
0.43
31
288
37
418
0.73
0.54
3.6
4.2
1.12
1.31
mmol/l
1.14
23
385
12
163
0.68
0.52
4.3
5.0
1.42
2.07
ug/l
—
7
134
39
432
0.75
0.45
4.1
4.8
3.96
4.60
mmol/l
2.70
25
401
20
161
1.35
0.44
2.0
3.5
2.35
2.35
mmol/l
0.04
14
136
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
43
467
0.76
0.40
23.2
18.4
73.09
77.73
umol/l
0.46
43
467
39
427
0.78
0.37
4.2
4.7
1.51
1.49
mmol/l
0.12
25
394
41
441
0.80
0.29
4.2
5.2
2.08
2.67
mmol/l
2.85
28
407
39
358
1.23
0.28
5.3
7.9
73.15
79.24
u/l
0.96
33
328
40
429
0.82
0.26
5.3
4.9
6.14
6.00
mmol/l
0.22
30
397
5
37
1.38
0.24
1.2
2.2
1.66
1.58
%
—
5
32
18
207
0.82
0.23
5.0
4.3
—
—
—
0
0
39
416
0.84
0.22
6.9
5.8
41.32
40.01
mmol/mol
0.37
29
391
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
12
140
0.82
0.17
1.8
3.7
21.50
27.56
u/l
2.91
12
128
42
401
1.14
0.13
5.7
5.0
1.62
1.94
mu/l
1.44
37
366
19
174
1.13
0.11
1.5
2.0
88.68
95.01
pmol/l
0.25
11
85
16
174
0.89
0.09
1.9
2.1
69.45
76.30
nmol/l
0.32
11
148
5
60
0.82
0.08
2.4
1.3
—
—
—
0
0
7
63
1.12
0.08
5.3
5.1
3.74
2.34
mmol/l
—
7
49
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
6.2
—
198.14
—
0
5
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
43.62
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
9.00
—
0
5
0
5
0.00
0.00
0.0
1.4
—
18.40
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
215.17
—
0
6
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
848.00
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
178.86
—
0
7
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
2.35
—
0
5
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: PDMED_TRIHEXYPHENIDYL – Use of trihexyphenidyl
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).